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Results for FHL1

Z-value: 2.57

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Transcription factors associated with FHL1

Gene Symbol Gene ID Gene Info
FHL1
S000006308 Regulator of ribosomal protein (RP) transcription

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
FHL1YPR104C0.252.1e-01Click!

Activity profile of FHL1 motif

Sorted Z-values of FHL1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YNL178W 26.11
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YGR108W 22.22
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YLR349W 20.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C
YFR055W 19.87
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YLR348C 19.53
DIC1
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
YLR448W 19.08
RPL6B
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA
YFR056C 17.95 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YHL033C 15.79
RPL8A
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YKR092C 15.73
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YKR075C 15.68 Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR154C 14.81
RNH203
Ribonuclease H2 subunit, required for RNase H2 activity
YOR029W 13.22 Dubious open reading frame unlikely to encode a functional protein; based on available experimental and comparative sequence data
YLR029C 12.71
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YOR063W 12.63
RPL3
Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus
YNL030W 12.57
HHF2
One of two identical histone H4 proteins (see also HHF1); core histone required for chromatin assembly and chromosome function; contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity
YOR028C 11.86
CIN5
Basic leucine zipper transcriptional factor of the yAP-1 family that mediates pleiotropic drug resistance and salt tolerance; localizes constitutively to the nucleus
YLR154W-A 11.85 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YOL086C 11.77
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YDR098C 11.54
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YLR154W-B 11.49 Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand
YGL123C-A 11.30 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YGL123W 11.28
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YDL047W 11.12
SIT4
Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization
YJL190C 11.06
RPS22A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins
YFR031C-A 10.95
RPL2A
Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins
YDL023C 10.90 Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance
YDR033W 10.76
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YPL037C 10.62
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YLR257W 9.91 Putative protein of unknown function
YPL263C 9.64
KEL3
Cytoplasmic protein of unknown function
YJR145C 9.58
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YGR249W 9.56
MGA1
Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants
YDL022W 9.37
GPD1
NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p
YDL055C 9.04
PSA1
GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure
YBR189W 9.02
RPS9B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins
YER102W 8.97
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YGR040W 8.96
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YJR123W 8.93
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YEL040W 8.81
UTR2
Cell wall protein that functions in the transfer of chitin to beta(1-6)glucan; putative chitin transglycosidase; glycosylphosphatidylinositol (GPI)-anchored protein localized to the bud neck; has a role in cell wall maintenance
YGL147C 8.65
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YDL211C 8.62 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YJL011C 8.49
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YGL103W 8.48
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YDL236W 8.28
PHO13
Alkaline phosphatase specific for p-nitrophenyl phosphate, involved in dephosphorylation of histone II-A and casein
YJR094W-A 8.26
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YNL289W 8.16
PCL1
Pho85 cyclin of the Pcl1,2-like subfamily, involved in entry into the mitotic cell cycle and regulation of morphogenesis, localizes to sites of polarized cell growth
YLR154W-C 8.08
TAR1
Mitochondrial protein of unknown function, overexpression suppresses an rpo41 mutation affecting mitochondrial RNA polymerase; encoded within the 25S rRNA gene on the opposite strand
YHL015W 8.01
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YOR030W 8.00
DFG16
Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p
YNL301C 8.00
RPL18B
Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein
YOL039W 7.66
RPP2A
Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YIL133C 7.58
RPL16A
N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p
YPL081W 7.53
RPS9A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins
YMR199W 7.51
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YDL022C-A 7.43 Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR
YDR447C 7.40
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YOL124C 7.38
TRM11
Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain
YIR021W 7.37
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YOL040C 7.27
RPS15
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins
YIL056W 7.22
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YGR180C 7.17
RNR4
Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits
YMR083W 7.15
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YGR242W 7.01 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C
YPR170W-B 7.00 Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C
YNR009W 6.99
NRM1
Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase
YLR441C 6.98
RPS1A
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein
YGR152C 6.94
RSR1
GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
YIL169C 6.93 Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene
YNR016C 6.81
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YLR137W 6.80 Putative protein of unknown function
YEL068C 6.79 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YLR367W 6.79
RPS22B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins
YBR048W 6.76
RPS11B
Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins
YOL127W 6.75
RPL25
Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 26S rRNA via a conserved C-terminal motif
YER137C 6.67 Putative protein of unknown function
YNL031C 6.67
HHT2
One of two identical histone H3 proteins (see also HHT1); core histone required for chromatin assembly, involved in heterochromatin-mediated telomeric and HM silencing; regulated by acetylation, methylation, and mitotic phosphorylation
YPL250W-A 6.56 Identified by fungal homology and RT-PCR
YBR249C 6.49
ARO4
3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan
YPL177C 6.46
CUP9
Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription
YGL076C 6.42
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YHR181W 6.42
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YGR251W 6.40 Putative protein of unknown function; deletion mutant has defects in pre-rRNA processing; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the nucleolus; YGR251W is an essential gene
YGL179C 6.38
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YGL039W 6.38 Oxidoreductase, catalyzes NADPH-dependent reduction of the bicyclic diketone bicyclo[2.2.2]octane-2,6-dione (BCO2,6D) to the chiral ketoalcohol (1R,4S,6S)-6-hydroxybicyclo[2.2.2]octane-2-one (BCO2one6ol)
YBR088C 6.32
POL30
Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair
YKL096W-A 6.24
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YPL249C-A 6.23
RPL36B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA
YMR049C 6.16
ERB1
Protein required for maturation of the 25S and 5.8S ribosomal RNAs; constituent of 66S pre-ribosomal particles; homologous to mammalian Bop1
YPR170W-A 6.16 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry
YFL022C 6.15
FRS2
Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
YBR158W 6.15
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YDL048C 6.13
STP4
Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p
YGR241C 6.09
YAP1802
Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family
YHR013C 6.08
ARD1
Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing
YIL148W 6.06
RPL40A
Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes
YPR171W 5.98
BSP1
Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton
YOL123W 5.94
HRP1
Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences
YLR372W 5.92
SUR4
Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis
YOL103W 5.91
ITR2
Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively
YGR155W 5.89
CYS4
Cystathionine beta-synthase, catalyzes the synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis
YPR102C 5.87
RPL11A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Bp; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11
YCR018C 5.84
SRD1
Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation
YLR437C 5.77 Putative protein of unknown function; epitope tagged protein localizes to the cytoplasm
YGR086C 5.48
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YHR010W 5.47
RPL27A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein
YPR170C 5.40 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B
YER109C 5.38
FLO8
Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene
YIL118W 5.24
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YLR388W 5.22
RPS29A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins
YER124C 5.18
DSE1
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall
YKR093W 5.17
PTR2
Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p
YDR399W 5.17
HPT1
Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome
YDL085C-A 5.10 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus
YGR140W 5.07
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YPR069C 5.06
SPE3
Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells
YLR261C 5.04
VPS63
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect
YNL182C 5.00
IPI3
Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles
YHR174W 4.99
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YOR315W 4.99
SFG1
Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate
YGL035C 4.99
MIG1
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase
YGR181W 4.96
TIM13
Mitochondrial intermembrane space protein, forms a complex with TIm8p that mediates import and insertion of a subset of polytopic inner membrane proteins; may prevent aggregation of incoming proteins in a chaperone-like manner
YDR345C 4.96
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YHR046C 4.93
INM1
Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
YGR138C 4.93
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YDR341C 4.90 Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YJL212C 4.89
OPT1
Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family
YLR355C 4.87
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YJL196C 4.85
ELO1
Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids
YDL164C 4.83
CDC9
DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
YBL076C 4.81
ILS1
Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A
YJL158C 4.80
CIS3
Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family
YIL053W 4.79
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YOR342C 4.77 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YFL015W-A 4.68 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YDL205C 4.63
HEM3
Phorphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p
YJL107C 4.61 Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi
YML063W 4.60
RPS1B
Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein
YFR054C 4.60 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOL085C 4.59 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YDL163W 4.57 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase
YMR144W 4.56 Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene
YNR072W 4.55
HXT17
Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose
YKL164C 4.55
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YDR261C 4.53
EXG2
Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
YGR245C 4.51
SDA1
Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YDR064W 4.51
RPS13
Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins
YOR092W 4.50
ECM3
Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation
YJL029C 4.49
VPS53
Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting
YEL066W 4.43
HPA3
D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro
YJL194W 4.40
CDC6
Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p
YNL231C 4.39
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YKR074W 4.36
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YGR151C 4.35 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C
YHR180W-A 4.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YHR020W 4.33 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene
YGR214W 4.29
RPS0A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal
YFL015C 4.29 Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene
YPR148C 4.28 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL218C 4.18
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YLL028W 4.17
TPO1
Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane
YGR106C 4.15
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YJR105W 4.15
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YML026C 4.14
RPS18B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins
YOR107W 4.14
RGS2
Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p
YOR073W-A 4.14 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR
YIL009W 4.09
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YPL245W 4.07 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm
YOR074C 4.04
CDC21
Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S
YHR154W 4.01
RTT107
Protein implicated in Mms22-dependent DNA repair during S phase, DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BRCT domains; has a role in regulation of Ty1 transposition
YPR043W 3.99
RPL43A
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype
YHR144C 3.97
DCD1
Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated
YOR327C 3.94
SNC2
Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins
YMR142C 3.90
RPL13B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein
YBL085W 3.88
BOI1
Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain
YDR044W 3.88
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YPL256C 3.81
CLN2
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YJL010C 3.78
NOP9
Essential component of pre-40S ribosomes that is required for early cleavages of 35S pre-rRNA and hence formation of 18S rRNA; binds RNA in vitro and contains multiple pumilio-like repeats
YMR143W 3.74
RPS16A
Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins
YMR183C 3.74
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YPL137C 3.72
GIP3
Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments
YPL239W 3.71
YAR1
Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock
YBR023C 3.70
CHS3
Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
YDR279W 3.70
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YNR001W-A 3.69 Dubious open reading frame unlikely to encode a functional protein; identified by homology
YNL300W 3.68 Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid
YCR065W 3.67
HCM1
Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role
YPR050C 3.66 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W
YEL067C 3.61 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YHL003C 3.59
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YGL105W 3.56
ARC1
Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids
YJL136C 3.56
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YNL079C 3.55
TPM1
Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently
YKL122C 3.55
SRP21
Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm
YKL128C 3.55
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YMR015C 3.54
ERG5
C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs
YOL101C 3.49
IZH4
Membrane protein involved in zinc metabolism, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism
YGL135W 3.49
RPL1B
N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal
YPL090C 3.49
RPS6A
Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein
YBR300C 3.47 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene
YCL018W 3.46
LEU2
Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway

Network of associatons between targets according to the STRING database.

First level regulatory network of FHL1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 19.0 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
4.1 73.6 GO:0006407 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
3.9 11.8 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
3.4 23.6 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
3.1 21.6 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
3.0 11.8 GO:0014070 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
2.9 20.4 GO:0006835 dicarboxylic acid transport(GO:0006835)
2.8 13.8 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
2.7 10.8 GO:0030497 fatty acid elongation(GO:0030497)
2.7 8.0 GO:0009177 deoxyribonucleoside monophosphate biosynthetic process(GO:0009157) deoxyribonucleoside monophosphate metabolic process(GO:0009162) pyrimidine deoxyribonucleoside monophosphate metabolic process(GO:0009176) pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177)
2.5 7.5 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
2.5 7.4 GO:0046416 D-amino acid metabolic process(GO:0046416)
2.5 7.4 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
2.3 4.7 GO:2000883 starch metabolic process(GO:0005982) starch catabolic process(GO:0005983) regulation of starch catabolic process by regulation of transcription from RNA polymerase II promoter(GO:0035956) positive regulation of starch catabolic process by positive regulation of transcription from RNA polymerase II promoter(GO:0035957) regulation of starch catabolic process(GO:2000881) positive regulation of starch catabolic process(GO:2000883) regulation of starch metabolic process(GO:2000904) positive regulation of starch metabolic process(GO:2000906)
2.3 9.4 GO:0000296 spermine transport(GO:0000296)
2.3 9.2 GO:0006072 glycerol-3-phosphate metabolic process(GO:0006072)
2.3 9.2 GO:0009423 chorismate biosynthetic process(GO:0009423)
2.3 313.9 GO:0002181 cytoplasmic translation(GO:0002181)
2.2 2.2 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
2.2 11.2 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
2.2 10.8 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
2.1 6.2 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
2.0 13.8 GO:0034729 histone H3-K79 methylation(GO:0034729)
1.9 5.7 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
1.9 1.9 GO:0010695 regulation of spindle pole body separation(GO:0010695)
1.8 9.1 GO:0045903 positive regulation of translational fidelity(GO:0045903)
1.8 1.8 GO:0042710 biofilm formation(GO:0042710)
1.8 9.0 GO:0070813 hydrogen sulfide metabolic process(GO:0070813) hydrogen sulfide biosynthetic process(GO:0070814)
1.8 5.3 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
1.7 6.8 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
1.7 15.2 GO:0042538 hyperosmotic salinity response(GO:0042538)
1.6 4.9 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
1.6 7.9 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
1.6 11.0 GO:0006116 NADH oxidation(GO:0006116)
1.5 9.2 GO:0006166 purine ribonucleoside salvage(GO:0006166)
1.5 4.6 GO:0023021 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
1.5 4.6 GO:0008216 spermidine metabolic process(GO:0008216)
1.5 10.6 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.4 7.2 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
1.4 4.3 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.4 5.7 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
1.4 5.6 GO:0032878 regulation of establishment or maintenance of cell polarity(GO:0032878)
1.2 3.7 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439) negative regulation of ubiquitin protein ligase activity(GO:1904667)
1.2 7.3 GO:0009099 valine biosynthetic process(GO:0009099)
1.2 10.8 GO:0006450 regulation of translational fidelity(GO:0006450)
1.2 3.6 GO:0045901 positive regulation of translational elongation(GO:0045901)
1.1 4.5 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
1.1 15.8 GO:0010383 cell wall polysaccharide metabolic process(GO:0010383)
1.1 12.4 GO:0006273 lagging strand elongation(GO:0006273)
1.1 5.3 GO:0051351 positive regulation of ligase activity(GO:0051351)
1.1 9.5 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
1.0 7.3 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
1.0 3.1 GO:0030541 plasmid partitioning(GO:0030541)
1.0 4.1 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
1.0 5.9 GO:0043457 regulation of cellular respiration(GO:0043457)
1.0 5.8 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
1.0 2.9 GO:1901352 regulation of phosphatidylglycerol biosynthetic process(GO:1901351) negative regulation of phosphatidylglycerol biosynthetic process(GO:1901352)
0.9 3.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
0.9 3.7 GO:0030835 regulation of actin filament depolymerization(GO:0030834) negative regulation of actin filament depolymerization(GO:0030835) barbed-end actin filament capping(GO:0051016) actin filament capping(GO:0051693)
0.9 7.3 GO:0006857 oligopeptide transport(GO:0006857)
0.9 1.8 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.9 9.8 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.9 3.5 GO:0006448 regulation of translational elongation(GO:0006448)
0.9 5.3 GO:0070941 eisosome assembly(GO:0070941)
0.9 2.6 GO:0006567 threonine catabolic process(GO:0006567)
0.9 3.5 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.8 2.5 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.8 8.8 GO:0007120 axial cellular bud site selection(GO:0007120)
0.8 7.2 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.8 3.9 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.8 7.7 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
0.8 13.8 GO:0030488 tRNA methylation(GO:0030488)
0.8 4.6 GO:0009306 protein secretion(GO:0009306)
0.8 11.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.7 6.7 GO:0051320 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.7 2.2 GO:0006624 vacuolar protein processing(GO:0006624)
0.7 3.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.7 3.6 GO:0007119 budding cell isotropic bud growth(GO:0007119)
0.7 0.7 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.7 3.5 GO:0072668 obsolete tubulin complex biogenesis(GO:0072668)
0.7 6.2 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 1.4 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.7 7.4 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.7 7.9 GO:0036388 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
0.7 3.3 GO:0046037 GMP metabolic process(GO:0046037)
0.6 6.5 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.6 0.6 GO:0001933 negative regulation of protein phosphorylation(GO:0001933)
0.6 11.5 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.6 5.0 GO:0051231 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.6 2.5 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.6 1.9 GO:0071044 histone mRNA metabolic process(GO:0008334) histone mRNA catabolic process(GO:0071044)
0.6 1.9 GO:0019255 glucose 1-phosphate metabolic process(GO:0019255)
0.6 2.5 GO:0098740 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 3.0 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.6 8.9 GO:0042797 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
0.6 0.6 GO:0045337 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.6 3.0 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.6 2.3 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.6 5.0 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.5 3.3 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.5 2.7 GO:0046459 short-chain fatty acid metabolic process(GO:0046459)
0.5 2.1 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.5 3.4 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.5 1.4 GO:0034030 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.5 1.4 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.5 1.4 GO:0035066 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.5 0.9 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.5 11.9 GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000472) rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
0.5 3.2 GO:0006901 vesicle coating(GO:0006901)
0.4 4.9 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.4 29.3 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.4 0.4 GO:0034473 U1 snRNA 3'-end processing(GO:0034473)
0.4 2.2 GO:0001402 signal transduction involved in filamentous growth(GO:0001402)
0.4 0.9 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.4 1.8 GO:0071902 positive regulation of protein serine/threonine kinase activity(GO:0071902)
0.4 1.3 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.4 2.6 GO:0006491 N-glycan processing(GO:0006491)
0.4 1.7 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.4 4.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.4 9.8 GO:0002097 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.4 0.8 GO:0015936 coenzyme A metabolic process(GO:0015936) nucleoside bisphosphate metabolic process(GO:0033865) ribonucleoside bisphosphate metabolic process(GO:0033875) purine nucleoside bisphosphate metabolic process(GO:0034032)
0.4 2.8 GO:0034501 protein localization to kinetochore(GO:0034501)
0.4 3.5 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.4 1.6 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.4 10.1 GO:0006696 ergosterol biosynthetic process(GO:0006696) phytosteroid biosynthetic process(GO:0016129) cellular alcohol biosynthetic process(GO:0044108) cellular lipid biosynthetic process(GO:0097384)
0.4 5.0 GO:0006414 translational elongation(GO:0006414)
0.4 2.3 GO:0048478 replication fork protection(GO:0048478)
0.4 3.8 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.4 0.4 GO:0034067 protein localization to Golgi apparatus(GO:0034067)
0.4 0.4 GO:0032447 protein urmylation(GO:0032447)
0.4 11.3 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.4 5.3 GO:0051666 actin cortical patch localization(GO:0051666)
0.4 1.1 GO:0048313 Golgi inheritance(GO:0048313)
0.4 1.5 GO:0006673 inositolphosphoceramide metabolic process(GO:0006673)
0.4 4.0 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.4 1.8 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 3.6 GO:0006817 phosphate ion transport(GO:0006817)
0.4 1.4 GO:0009229 thiamine diphosphate biosynthetic process(GO:0009229) thiamine diphosphate metabolic process(GO:0042357)
0.4 1.4 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509) amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 1.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.3 3.1 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.3 1.4 GO:0015883 FAD transport(GO:0015883)
0.3 8.6 GO:0098876 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.3 1.4 GO:0072417 response to biotic stimulus(GO:0009607) cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.3 0.3 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.3 4.7 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 1.3 GO:0015867 ATP transport(GO:0015867)
0.3 4.0 GO:0006446 regulation of translational initiation(GO:0006446)
0.3 1.3 GO:0006657 CDP-choline pathway(GO:0006657)
0.3 0.6 GO:0006596 polyamine biosynthetic process(GO:0006596)
0.3 0.6 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.3 1.0 GO:0031335 regulation of sulfur amino acid metabolic process(GO:0031335)
0.3 1.6 GO:0006110 regulation of glycolytic process(GO:0006110)
0.3 0.3 GO:0007232 osmosensory signaling pathway via Sho1 osmosensor(GO:0007232)
0.3 1.2 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.3 0.3 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.3 4.0 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.3 1.2 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.3 1.2 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.3 7.5 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.3 0.6 GO:0051865 protein autoubiquitination(GO:0051865)
0.3 1.8 GO:0097549 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.3 1.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.3 0.6 GO:0030472 mitotic spindle organization in nucleus(GO:0030472)
0.3 0.3 GO:0009202 deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.3 3.1 GO:0030011 maintenance of cell polarity(GO:0030011)
0.3 3.9 GO:0006334 nucleosome assembly(GO:0006334)
0.3 2.2 GO:0006415 translational termination(GO:0006415)
0.3 0.8 GO:0032147 activation of protein kinase activity(GO:0032147)
0.3 6.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.3 1.3 GO:0006662 glycerol ether metabolic process(GO:0006662) ether metabolic process(GO:0018904)
0.3 0.8 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 1.0 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.3 5.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.3 0.5 GO:0031135 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 0.5 GO:0031292 gene conversion at mating-type locus, DNA double-strand break processing(GO:0031292)
0.2 1.2 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 1.2 GO:0006272 leading strand elongation(GO:0006272)
0.2 2.8 GO:0009636 response to toxic substance(GO:0009636)
0.2 0.9 GO:0018344 protein geranylgeranylation(GO:0018344)
0.2 6.6 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.2 5.2 GO:0006413 translational initiation(GO:0006413)
0.2 3.4 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 1.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.2 1.1 GO:0048255 RNA stabilization(GO:0043489) mRNA stabilization(GO:0048255)
0.2 1.0 GO:0033673 negative regulation of protein kinase activity(GO:0006469) negative regulation of kinase activity(GO:0033673)
0.2 0.8 GO:0007329 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.2 0.6 GO:2000002 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.2 19.2 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.2 5.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.2 0.6 GO:0033559 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
0.2 4.5 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.2 0.4 GO:0009847 spore germination(GO:0009847)
0.2 0.9 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 0.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.2 1.6 GO:0071027 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027)
0.2 0.9 GO:0018023 peptidyl-lysine trimethylation(GO:0018023)
0.2 0.2 GO:0000092 mitotic anaphase B(GO:0000092)
0.2 0.5 GO:1902707 glucose catabolic process(GO:0006007) glycolytic fermentation to ethanol(GO:0019655) glycolytic fermentation(GO:0019660) hexose catabolic process to ethanol(GO:1902707)
0.2 0.7 GO:0007009 plasma membrane organization(GO:0007009)
0.2 0.3 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.2 1.2 GO:0000282 cellular bud site selection(GO:0000282) mitotic cytokinesis, site selection(GO:1902408)
0.2 2.7 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 0.3 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.2 1.0 GO:0001041 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.2 1.5 GO:0051668 localization within membrane(GO:0051668)
0.2 5.0 GO:0008033 tRNA processing(GO:0008033)
0.2 0.3 GO:0034389 lipid particle organization(GO:0034389)
0.2 1.0 GO:0051294 establishment of mitotic spindle orientation(GO:0000132) establishment of mitotic spindle localization(GO:0040001) establishment of spindle orientation(GO:0051294)
0.2 1.7 GO:0000750 pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0000750) signal transduction involved in conjugation with cellular fusion(GO:0032005)
0.2 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.2 1.7 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 0.7 GO:0042401 amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401)
0.1 4.8 GO:0006470 protein dephosphorylation(GO:0006470)
0.1 0.6 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.1 0.4 GO:0006517 protein deglycosylation(GO:0006517)
0.1 0.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.1 1.3 GO:0030473 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.1 1.7 GO:0042144 vacuole fusion, non-autophagic(GO:0042144)
0.1 2.0 GO:0031109 microtubule polymerization or depolymerization(GO:0031109)
0.1 0.4 GO:0051446 positive regulation of meiotic nuclear division(GO:0045836) positive regulation of meiotic cell cycle(GO:0051446)
0.1 0.9 GO:0044091 ascospore-type prospore membrane assembly(GO:0032120) membrane biogenesis(GO:0044091) membrane assembly(GO:0071709)
0.1 0.7 GO:0048017 inositol lipid-mediated signaling(GO:0048017)
0.1 0.8 GO:0000321 re-entry into mitotic cell cycle(GO:0000320) re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.1 0.2 GO:0016926 protein desumoylation(GO:0016926)
0.1 2.3 GO:0051445 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.1 3.3 GO:0045047 protein targeting to ER(GO:0045047)
0.1 0.6 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.1 0.2 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) G1 DNA damage checkpoint(GO:0044783) mitotic G1/S transition checkpoint(GO:0044819)
0.1 1.7 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.3 GO:0046473 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.1 1.2 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 1.9 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
0.1 0.8 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.1 0.4 GO:0034661 ncRNA catabolic process(GO:0034661)
0.1 0.5 GO:0051131 chaperone-mediated protein complex assembly(GO:0051131)
0.1 0.4 GO:0045116 protein neddylation(GO:0045116)
0.1 0.5 GO:0046351 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.1 0.6 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.1 0.1 GO:0018342 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 0.2 GO:0046083 adenine metabolic process(GO:0046083)
0.1 4.1 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.1 1.0 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.1 0.3 GO:0006880 intracellular sequestering of iron ion(GO:0006880) sequestering of metal ion(GO:0051238) sequestering of iron ion(GO:0097577)
0.1 1.3 GO:0016311 dephosphorylation(GO:0016311)
0.1 0.8 GO:0015698 inorganic anion transport(GO:0015698)
0.1 0.2 GO:0010133 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.1 0.2 GO:0009097 isoleucine biosynthetic process(GO:0009097)
0.1 0.1 GO:0006363 termination of RNA polymerase I transcription(GO:0006363)
0.1 0.6 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.1 0.1 GO:0090262 regulation of transcription-coupled nucleotide-excision repair(GO:0090262) regulation of nucleotide-excision repair(GO:2000819) regulation of transcription elongation from RNA polymerase I promoter(GO:2001207) positive regulation of transcription elongation from RNA polymerase I promoter(GO:2001209)
0.1 0.2 GO:0046777 protein autophosphorylation(GO:0046777)
0.1 0.1 GO:0015680 intracellular copper ion transport(GO:0015680)
0.1 0.4 GO:0007186 G-protein coupled receptor signaling pathway(GO:0007186)
0.1 0.7 GO:0006513 protein monoubiquitination(GO:0006513)
0.1 0.2 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 0.4 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
0.1 0.1 GO:0019358 nicotinate nucleotide biosynthetic process(GO:0019357) nicotinate nucleotide salvage(GO:0019358) pyridine nucleotide salvage(GO:0019365) nicotinate nucleotide metabolic process(GO:0046497)
0.1 1.0 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 0.9 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.0 GO:0016584 nucleosome positioning(GO:0016584)
0.0 1.5 GO:0048193 Golgi vesicle transport(GO:0048193)
0.0 0.2 GO:0010992 ubiquitin homeostasis(GO:0010992)
0.0 0.2 GO:0016560 protein import into peroxisome matrix, docking(GO:0016560) protein to membrane docking(GO:0022615)
0.0 0.0 GO:2000242 negative regulation of reproductive process(GO:2000242)
0.0 0.0 GO:0051261 protein depolymerization(GO:0051261)
0.0 0.2 GO:0035268 protein mannosylation(GO:0035268) protein O-linked mannosylation(GO:0035269) mannosylation(GO:0097502)
0.0 0.4 GO:0006515 misfolded or incompletely synthesized protein catabolic process(GO:0006515)
0.0 0.2 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.0 0.1 GO:0032958 inositol phosphate biosynthetic process(GO:0032958)
0.0 0.3 GO:0006379 mRNA cleavage(GO:0006379)
0.0 0.0 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.1 GO:0030010 establishment of cell polarity(GO:0030010)
0.0 0.3 GO:0006744 ubiquinone metabolic process(GO:0006743) ubiquinone biosynthetic process(GO:0006744) ketone biosynthetic process(GO:0042181) quinone metabolic process(GO:1901661) quinone biosynthetic process(GO:1901663)
0.0 0.1 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.0 0.1 GO:0009395 phospholipid catabolic process(GO:0009395)
0.0 1.1 GO:0016072 rRNA metabolic process(GO:0016072)
0.0 0.3 GO:0042254 ribosome biogenesis(GO:0042254)
0.0 0.1 GO:0010529 negative regulation of transposition, RNA-mediated(GO:0010526) negative regulation of transposition(GO:0010529)
0.0 0.6 GO:0051604 protein maturation(GO:0051604)
0.0 0.5 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) ERAD pathway(GO:0036503)
0.0 0.1 GO:0035376 sterol import(GO:0035376)
0.0 0.1 GO:0000715 nucleotide-excision repair, DNA damage recognition(GO:0000715)
0.0 0.1 GO:0031506 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.0 0.2 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.0 0.1 GO:1901072 aminoglycan catabolic process(GO:0006026) chitin catabolic process(GO:0006032) amino sugar catabolic process(GO:0046348) glucosamine-containing compound catabolic process(GO:1901072)
0.0 0.0 GO:0061395 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061395) cellular response to arsenic-containing substance(GO:0071243)
0.0 0.4 GO:0046474 glycerophospholipid biosynthetic process(GO:0046474)
0.0 0.1 GO:0006303 double-strand break repair via nonhomologous end joining(GO:0006303)
0.0 0.1 GO:0016125 steroid metabolic process(GO:0008202) sterol metabolic process(GO:0016125)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
3.5 10.6 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
3.2 197.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
3.1 9.2 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
3.0 3.0 GO:0005697 telomerase holoenzyme complex(GO:0005697)
2.5 212.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.5 7.4 GO:0070545 PeBoW complex(GO:0070545)
2.3 6.8 GO:0031415 NatA complex(GO:0031415)
2.0 24.5 GO:0000788 nuclear nucleosome(GO:0000788)
1.9 1.9 GO:0070938 actomyosin contractile ring(GO:0005826) contractile ring(GO:0070938)
1.7 6.9 GO:0030907 MBF transcription complex(GO:0030907)
1.7 5.1 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.7 28.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
1.7 5.0 GO:0097344 Rix1 complex(GO:0097344)
1.7 5.0 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
1.6 8.1 GO:0005641 nuclear envelope lumen(GO:0005641)
1.6 6.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
1.5 8.9 GO:0043527 tRNA methyltransferase complex(GO:0043527)
1.4 5.6 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
1.4 12.2 GO:0000144 cellular bud neck septin ring(GO:0000144)
1.2 3.6 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.1 4.5 GO:0000938 GARP complex(GO:0000938)
1.1 5.4 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
1.1 3.2 GO:0070985 TFIIK complex(GO:0070985)
1.0 17.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
1.0 4.1 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.0 4.0 GO:0030892 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
1.0 3.9 GO:0031518 CBF3 complex(GO:0031518)
0.9 2.8 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
0.9 0.9 GO:0000133 polarisome(GO:0000133)
0.9 1.8 GO:0008278 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.9 3.6 GO:0000220 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.9 4.3 GO:0044462 cell wall part(GO:0044426) external encapsulating structure part(GO:0044462)
0.8 2.5 GO:0033186 CAF-1 complex(GO:0033186)
0.8 2.3 GO:0044697 HICS complex(GO:0044697)
0.7 3.0 GO:0017053 transcriptional repressor complex(GO:0017053)
0.7 5.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.7 3.5 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.7 3.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.7 3.4 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.7 4.0 GO:0005940 septin ring(GO:0005940)
0.7 4.0 GO:0032126 eisosome(GO:0032126)
0.6 1.9 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.6 3.8 GO:0005871 kinesin complex(GO:0005871)
0.6 6.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.6 3.5 GO:0048500 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.6 2.2 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.6 2.8 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 4.4 GO:0005688 U6 snRNP(GO:0005688)
0.5 1.0 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.5 8.3 GO:0005656 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
0.5 2.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 3.6 GO:0032432 actin filament bundle(GO:0032432)
0.5 18.0 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.5 2.9 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.5 0.9 GO:0000786 nucleosome(GO:0000786)
0.4 1.8 GO:0000811 GINS complex(GO:0000811)
0.4 1.7 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.4 2.9 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.4 3.3 GO:0017119 Golgi transport complex(GO:0017119)
0.4 0.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.4 4.5 GO:0030658 transport vesicle membrane(GO:0030658)
0.4 1.2 GO:0032301 MutSalpha complex(GO:0032301)
0.4 68.3 GO:0005933 cellular bud(GO:0005933)
0.4 1.6 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.4 1.2 GO:0000131 incipient cellular bud site(GO:0000131)
0.4 2.7 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.4 1.2 GO:0005662 DNA replication factor A complex(GO:0005662)
0.4 12.2 GO:0005657 replication fork(GO:0005657)
0.4 1.5 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.4 1.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.4 2.9 GO:0030008 TRAPP complex(GO:0030008)
0.4 2.2 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.4 5.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.3 0.7 GO:0005845 mRNA cap binding complex(GO:0005845)
0.3 2.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.3 12.0 GO:0005811 lipid particle(GO:0005811)
0.3 1.0 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.3 1.3 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.3 0.9 GO:0008275 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.3 1.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.3 0.6 GO:0032116 SMC loading complex(GO:0032116)
0.3 2.6 GO:0000137 Golgi cis cisterna(GO:0000137)
0.3 1.9 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) vacuolar proton-transporting V-type ATPase complex(GO:0016471) proton-transporting V-type ATPase complex(GO:0033176) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.3 2.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.3 0.5 GO:0034518 RNA cap binding complex(GO:0034518)
0.3 0.3 GO:0071561 nucleus-vacuole junction(GO:0071561)
0.3 0.8 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 1.8 GO:0016272 prefoldin complex(GO:0016272)
0.3 1.8 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.2 1.0 GO:0000796 condensin complex(GO:0000796) nuclear condensin complex(GO:0000799)
0.2 0.7 GO:0042729 DASH complex(GO:0042729)
0.2 0.9 GO:0097196 Shu complex(GO:0097196)
0.2 0.7 GO:0005827 polar microtubule(GO:0005827) tubulin complex(GO:0045298)
0.2 0.5 GO:0030689 Noc complex(GO:0030689)
0.2 0.9 GO:0097255 R2TP complex(GO:0097255)
0.2 5.9 GO:0005844 polysome(GO:0005844)
0.2 1.3 GO:0031499 TRAMP complex(GO:0031499)
0.2 0.2 GO:0000145 exocyst(GO:0000145)
0.2 1.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.2 40.1 GO:0005730 nucleolus(GO:0005730)
0.2 2.7 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.2 2.4 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.2 3.4 GO:0016586 RSC complex(GO:0016586)
0.2 0.2 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.2 1.9 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 1.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.2 1.0 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.2 2.7 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 0.3 GO:0005824 outer plaque of spindle pole body(GO:0005824)
0.2 0.5 GO:0032807 DNA ligase IV complex(GO:0032807)
0.2 2.5 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.2 0.5 GO:0000814 ESCRT II complex(GO:0000814)
0.2 1.4 GO:0000243 commitment complex(GO:0000243)
0.1 2.7 GO:0030659 vesicle membrane(GO:0012506) cytoplasmic vesicle membrane(GO:0030659)
0.1 0.4 GO:0031985 Golgi cisterna(GO:0031985)
0.1 1.1 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.1 GO:0043614 multi-eIF complex(GO:0043614)
0.1 0.8 GO:0000346 transcription export complex(GO:0000346)
0.1 1.2 GO:0036452 ESCRT complex(GO:0036452)
0.1 0.4 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.1 0.2 GO:0031229 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.1 0.6 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 1.4 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 0.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 0.6 GO:0030133 transport vesicle(GO:0030133)
0.1 0.7 GO:0048188 histone methyltransferase complex(GO:0035097) Set1C/COMPASS complex(GO:0048188)
0.1 0.4 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.3 GO:0000839 Hrd1p ubiquitin ligase complex(GO:0000836) Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.1 0.2 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.1 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.1 0.2 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.1 4.5 GO:0000139 Golgi membrane(GO:0000139)
0.1 0.4 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.1 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.5 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.3 GO:0031262 Ndc80 complex(GO:0031262)
0.1 0.3 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.1 1.6 GO:0044445 cytosolic part(GO:0044445)
0.0 0.0 GO:0000172 ribonuclease MRP complex(GO:0000172)
0.0 1.1 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.0 0.2 GO:0000818 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.5 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.1 GO:0000417 HIR complex(GO:0000417)
0.0 0.7 GO:0005874 microtubule(GO:0005874)
0.0 1.0 GO:0005643 nuclear pore(GO:0005643)
0.0 0.1 GO:0000113 nucleotide-excision repair factor 4 complex(GO:0000113)
0.0 0.2 GO:0071004 U2-type prespliceosome(GO:0071004) prespliceosome(GO:0071010)
0.0 0.2 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152) anaphase-promoting complex(GO:0005680)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.5 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
4.6 27.3 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
3.9 15.8 GO:0070181 small ribosomal subunit rRNA binding(GO:0070181)
3.6 10.8 GO:0009922 fatty acid elongase activity(GO:0009922)
3.0 9.0 GO:0070568 guanylyltransferase activity(GO:0070568)
3.0 17.9 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
2.5 15.0 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.5 7.4 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
2.3 9.4 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
2.2 6.5 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
2.1 6.2 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
2.0 83.8 GO:0019843 rRNA binding(GO:0019843)
1.9 17.3 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
1.8 7.1 GO:0016841 ammonia-lyase activity(GO:0016841)
1.7 5.0 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
1.6 284.4 GO:0003735 structural constituent of ribosome(GO:0003735)
1.6 6.2 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
1.6 7.8 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
1.5 7.5 GO:0004707 MAP kinase activity(GO:0004707)
1.5 38.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.4 7.2 GO:0008525 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
1.4 14.5 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
1.4 4.2 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.3 5.2 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
1.3 5.1 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
1.2 16.1 GO:0070491 repressing transcription factor binding(GO:0070491)
1.2 4.8 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
1.1 6.8 GO:0070300 phosphatidic acid binding(GO:0070300)
1.1 3.4 GO:0004100 chitin synthase activity(GO:0004100)
1.1 3.2 GO:0051219 phosphoprotein binding(GO:0051219)
1.0 17.8 GO:0001056 RNA polymerase III activity(GO:0001056)
1.0 5.2 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.0 4.1 GO:0019206 nucleoside kinase activity(GO:0019206)
1.0 4.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.9 8.4 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.9 3.7 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.9 28.6 GO:0046982 protein heterodimerization activity(GO:0046982)
0.9 3.6 GO:0009378 four-way junction helicase activity(GO:0009378)
0.9 2.7 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.9 2.7 GO:0016504 peptidase activator activity(GO:0016504)
0.9 14.9 GO:0042803 protein homodimerization activity(GO:0042803)
0.9 2.6 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.9 3.4 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.8 0.8 GO:0015248 sterol transporter activity(GO:0015248)
0.8 2.5 GO:0051010 microtubule plus-end binding(GO:0051010)
0.8 2.5 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.8 2.5 GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.8 3.3 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.8 4.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.8 7.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.8 2.4 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.8 1.6 GO:0072341 modified amino acid binding(GO:0072341)
0.8 3.0 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.8 2.3 GO:0015198 oligopeptide transporter activity(GO:0015198)
0.8 2.3 GO:0005078 MAP-kinase scaffold activity(GO:0005078) signaling adaptor activity(GO:0035591)
0.7 6.0 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.7 2.9 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.7 20.6 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.7 3.5 GO:0008312 7S RNA binding(GO:0008312)
0.7 3.4 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.7 2.0 GO:0005262 calcium channel activity(GO:0005262)
0.7 24.5 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.7 2.0 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.6 1.9 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.6 9.1 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.6 1.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.6 1.8 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.6 1.8 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 3.0 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.6 1.8 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.6 1.7 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.6 2.2 GO:0055106 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
0.6 2.2 GO:0008079 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.5 3.2 GO:0016778 diphosphotransferase activity(GO:0016778)
0.5 0.5 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.5 2.6 GO:0008443 phosphofructokinase activity(GO:0008443)
0.5 4.5 GO:0004497 monooxygenase activity(GO:0004497)
0.5 3.9 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.5 1.5 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.5 3.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.5 1.4 GO:0019003 GDP binding(GO:0019003)
0.4 0.4 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.4 2.5 GO:0004312 fatty acid synthase activity(GO:0004312)
0.4 1.7 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.4 16.4 GO:0030674 protein binding, bridging(GO:0030674)
0.4 22.9 GO:0003924 GTPase activity(GO:0003924)
0.4 2.0 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.4 1.6 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.4 2.4 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.4 4.0 GO:0003746 translation elongation factor activity(GO:0003746)
0.4 1.2 GO:0015088 copper uptake transmembrane transporter activity(GO:0015088)
0.4 3.9 GO:0019239 deaminase activity(GO:0019239)
0.4 1.6 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.4 3.1 GO:0003777 microtubule motor activity(GO:0003777)
0.4 11.9 GO:0008135 translation factor activity, RNA binding(GO:0008135)
0.4 1.8 GO:0070403 NAD+ binding(GO:0070403)
0.4 5.5 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.4 2.5 GO:0051087 chaperone binding(GO:0051087)
0.3 1.0 GO:0003680 AT DNA binding(GO:0003680)
0.3 1.4 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.3 1.4 GO:0036002 pre-mRNA binding(GO:0036002)
0.3 7.5 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 2.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.3 1.3 GO:0004622 lysophospholipase activity(GO:0004622)
0.3 1.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.3 2.9 GO:0019209 kinase activator activity(GO:0019209) protein kinase activator activity(GO:0030295)
0.3 3.3 GO:0019904 protein domain specific binding(GO:0019904)
0.3 1.6 GO:0080130 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.3 1.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.3 3.7 GO:0005199 structural constituent of cell wall(GO:0005199)
0.3 0.6 GO:0000403 Y-form DNA binding(GO:0000403)
0.3 12.4 GO:0005096 GTPase activator activity(GO:0005096)
0.3 7.8 GO:0015631 tubulin binding(GO:0015631)
0.3 1.1 GO:0004771 sterol esterase activity(GO:0004771)
0.3 1.7 GO:0019201 nucleotide kinase activity(GO:0019201)
0.3 8.2 GO:0003779 actin binding(GO:0003779)
0.3 3.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.3 0.8 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 1.0 GO:0008242 omega peptidase activity(GO:0008242)
0.2 8.3 GO:0016791 phosphatase activity(GO:0016791)
0.2 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.2 1.9 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 2.7 GO:0005048 signal sequence binding(GO:0005048)
0.2 5.5 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.2 0.7 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 1.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.2 1.0 GO:0030145 manganese ion binding(GO:0030145)
0.2 0.6 GO:0070336 flap-structured DNA binding(GO:0070336)
0.2 1.4 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 1.2 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.0 GO:0003774 motor activity(GO:0003774)
0.2 0.7 GO:0008536 Ran GTPase binding(GO:0008536)
0.2 0.7 GO:0043139 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.2 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.2 0.9 GO:0030943 mitochondrion targeting sequence binding(GO:0030943)
0.2 0.7 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.2 0.9 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.2 0.5 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.2 2.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.2 1.3 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.0 GO:0001031 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.2 0.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 1.8 GO:0051213 dioxygenase activity(GO:0051213)
0.1 1.3 GO:0030276 clathrin binding(GO:0030276)
0.1 0.3 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 0.6 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.1 0.7 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.1 2.0 GO:0001671 ATPase activator activity(GO:0001671)
0.1 0.7 GO:0017069 snRNA binding(GO:0017069)
0.1 2.6 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 1.1 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 1.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.1 0.9 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 0.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 8.6 GO:0003682 chromatin binding(GO:0003682)
0.1 4.4 GO:0042393 histone binding(GO:0042393)
0.1 2.1 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 1.3 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.1 1.9 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 2.3 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 0.1 GO:0016972 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.1 0.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 1.2 GO:0046983 protein dimerization activity(GO:0046983)
0.1 2.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.4 GO:0008172 S-methyltransferase activity(GO:0008172)
0.1 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.4 GO:0001055 RNA polymerase II activity(GO:0001055)
0.1 1.6 GO:0004520 endodeoxyribonuclease activity(GO:0004520)
0.1 0.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.1 0.4 GO:0015173 aromatic amino acid transmembrane transporter activity(GO:0015173)
0.1 0.4 GO:0000026 alpha-1,2-mannosyltransferase activity(GO:0000026)
0.1 0.9 GO:0045182 translation regulator activity(GO:0045182)
0.1 0.9 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 0.2 GO:0016882 cyclo-ligase activity(GO:0016882)
0.1 2.0 GO:0043130 ubiquitin binding(GO:0043130)
0.1 1.0 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.1 0.3 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 3.1 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.1 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.1 0.2 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 0.8 GO:0051539 4 iron, 4 sulfur cluster binding(GO:0051539)
0.0 2.6 GO:0008289 lipid binding(GO:0008289)
0.0 0.1 GO:0019901 protein kinase binding(GO:0019901)
0.0 0.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.0 0.3 GO:0016776 phosphotransferase activity, phosphate group as acceptor(GO:0016776)
0.0 0.3 GO:0031386 protein tag(GO:0031386)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.4 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 2.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.5 GO:0030515 snoRNA binding(GO:0030515)
0.0 0.7 GO:0000030 mannosyltransferase activity(GO:0000030)
0.0 0.3 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.1 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.0 0.3 GO:0003727 single-stranded RNA binding(GO:0003727)
0.0 0.8 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.0 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.0 0.2 GO:0043495 protein anchor(GO:0043495)
0.0 0.1 GO:0015103 inorganic anion transmembrane transporter activity(GO:0015103)
0.0 0.2 GO:0015926 glucosidase activity(GO:0015926)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.0 PID SHP2 PATHWAY SHP2 signaling
1.5 6.1 PID E2F PATHWAY E2F transcription factor network
0.9 0.9 PID VEGFR1 PATHWAY VEGFR1 specific signals
0.9 4.3 PID PLK1 PATHWAY PLK1 signaling events
0.8 3.1 NABA CORE MATRISOME Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans
0.5 1.4 PID ATM PATHWAY ATM pathway
0.4 1.2 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.4 1.1 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.3 1.3 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.3 0.3 PID ERBB4 PATHWAY ErbB4 signaling events
0.3 3.6 NABA MATRISOME Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins
0.3 0.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.2 0.7 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 0.3 PID FGF PATHWAY FGF signaling pathway
0.2 0.6 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.4 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.1 0.8 PID ATR PATHWAY ATR signaling pathway
0.1 0.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 67.3 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
2.7 10.8 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
2.6 41.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
2.5 7.5 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
1.7 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
1.7 5.0 REACTOME SIGNALING BY INSULIN RECEPTOR Genes involved in Signaling by Insulin receptor
1.1 4.5 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 2.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
1.0 3.0 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.9 1.8 REACTOME SCF BETA TRCP MEDIATED DEGRADATION OF EMI1 Genes involved in SCF-beta-TrCP mediated degradation of Emi1
0.8 6.0 REACTOME SIGNALING BY GPCR Genes involved in Signaling by GPCR
0.7 0.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.7 4.7 REACTOME METABOLISM OF MRNA Genes involved in Metabolism of mRNA
0.6 2.4 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.5 1.5 REACTOME PLATELET ACTIVATION SIGNALING AND AGGREGATION Genes involved in Platelet activation, signaling and aggregation
0.5 1.4 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.4 2.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 1.2 REACTOME POL SWITCHING Genes involved in Polymerase switching
0.3 1.1 REACTOME SIGNALING BY ERBB4 Genes involved in Signaling by ERBB4
0.2 1.9 REACTOME M G1 TRANSITION Genes involved in M/G1 Transition
0.2 0.6 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
0.2 2.1 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 1.7 REACTOME CLASS I MHC MEDIATED ANTIGEN PROCESSING PRESENTATION Genes involved in Class I MHC mediated antigen processing & presentation
0.2 1.1 REACTOME CELL CYCLE MITOTIC Genes involved in Cell Cycle, Mitotic
0.2 0.6 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.1 0.9 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 0.3 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.1 0.2 REACTOME CELL CYCLE CHECKPOINTS Genes involved in Cell Cycle Checkpoints
0.1 0.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 0.3 REACTOME RNA POL II TRANSCRIPTION Genes involved in RNA Polymerase II Transcription