Results for FHL1
Z-value: 2.57
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Transcription factors associated with FHL1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
FHL1
|
S000006308 | Regulator of ribosomal protein (RP) transcription |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YNL178W Show fit | 26.11 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YGR108W Show fit | 22.22 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YLR349W Show fit | 20.39 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C |
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| YFR055W Show fit | 19.87 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YLR348C Show fit | 19.53 |
Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix |
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| YLR448W Show fit | 19.08 |
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA |
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| YFR056C Show fit | 17.95 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YHL033C Show fit | 15.79 |
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits |
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| YKR092C Show fit | 15.73 |
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 |
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| YKR075C Show fit | 15.68 |
Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS |
Network of associatons between targets according to the STRING database.
First level regulatory network of FHL1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 313.9 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 4.1 | 73.6 | GO:0006407 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.4 | 29.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 3.4 | 23.6 | GO:0043137 | DNA replication, removal of RNA primer(GO:0043137) |
| 3.1 | 21.6 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 2.9 | 20.4 | GO:0006835 | dicarboxylic acid transport(GO:0006835) |
| 0.2 | 19.2 | GO:0006913 | nucleocytoplasmic transport(GO:0006913) |
| 6.3 | 19.0 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 1.1 | 15.8 | GO:0010383 | cell wall polysaccharide metabolic process(GO:0010383) |
| 1.7 | 15.2 | GO:0042538 | hyperosmotic salinity response(GO:0042538) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.5 | 212.2 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 3.2 | 197.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.4 | 68.3 | GO:0005933 | cellular bud(GO:0005933) |
| 0.2 | 40.1 | GO:0005730 | nucleolus(GO:0005730) |
| 1.7 | 28.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 2.0 | 24.5 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 6.2 | 18.5 | GO:0032299 | ribonuclease H2 complex(GO:0032299) |
| 0.5 | 18.0 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 1.0 | 17.8 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 1.4 | 12.2 | GO:0000144 | cellular bud neck septin ring(GO:0000144) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 284.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.0 | 83.8 | GO:0019843 | rRNA binding(GO:0019843) |
| 1.5 | 38.9 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.9 | 28.6 | GO:0046982 | protein heterodimerization activity(GO:0046982) |
| 4.6 | 27.3 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
| 0.7 | 24.5 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.4 | 22.9 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.7 | 20.6 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 4.6 | 18.5 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 3.0 | 17.9 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6.1 | PID E2F PATHWAY | E2F transcription factor network |
| 1.7 | 5.0 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.9 | 4.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 3.6 | NABA MATRISOME | Ensemble of genes encoding extracellular matrix and extracellular matrix-associated proteins |
| 0.8 | 3.1 | NABA CORE MATRISOME | Ensemble of genes encoding core extracellular matrix including ECM glycoproteins, collagens and proteoglycans |
| 0.5 | 1.4 | PID ATM PATHWAY | ATM pathway |
| 0.3 | 1.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.4 | 1.2 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.4 | 1.1 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.9 | 0.9 | PID VEGFR1 PATHWAY | VEGFR1 specific signals |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.4 | 67.3 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 2.6 | 41.7 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 2.7 | 10.8 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 2.5 | 7.5 | REACTOME G1 S SPECIFIC TRANSCRIPTION | Genes involved in G1/S-Specific Transcription |
| 0.8 | 6.0 | REACTOME SIGNALING BY GPCR | Genes involved in Signaling by GPCR |
| 1.7 | 5.0 | REACTOME SIGNALING BY INSULIN RECEPTOR | Genes involved in Signaling by Insulin receptor |
| 0.7 | 4.7 | REACTOME METABOLISM OF MRNA | Genes involved in Metabolism of mRNA |
| 1.1 | 4.5 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.0 | 3.0 | REACTOME CITRIC ACID CYCLE TCA CYCLE | Genes involved in Citric acid cycle (TCA cycle) |
| 0.6 | 2.4 | REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE | Genes involved in Synthesis of PIPs at the Golgi membrane |