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Results for DOT6

Z-value: 1.45

Activity profile of DOT6 motif

Sorted Z-values of DOT6 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YJR094W-A 17.56
RPL43B
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein
YPL250W-A 16.39 Identified by fungal homology and RT-PCR
YNL178W 13.91
RPS3
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins
YDR033W 12.88
MRH1
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p
YFR055W 12.70
IRC7
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner
YPR119W 12.50
CLB2
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGR108W 12.34
CLB1
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome
YGL031C 11.63
RPL24A
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YFR056C 11.30 Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W
YBR158W 10.75
AMN1
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN)
YJR105W 10.53
ADO1
Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle
YOL086C 10.29
ADH1
Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway
YGL030W 9.68
RPL30
Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript
YGL076C 9.03
RPL7A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2)
YPR010C 8.79
RPA135
RNA polymerase I subunit A135
YML043C 8.69
RRN11
Protein required for rDNA transcription by RNA polymerase I, component of the core factor (CF) of rDNA transcription factor, which also contains Rrn6p and Rrn7p
YPL037C 8.13
EGD1
Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b
YIL053W 7.78
RHR2
Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress
YHR181W 7.73
SVP26
Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment
YIR021W 7.60
MRS1
Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA
YOR101W 7.42
RAS1
GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes
YMR246W 7.32
FAA4
Long chain fatty acyl-CoA synthetase, regulates protein modification during growth in the presence of ethanol, functions to incorporate palmitic acid into phospholipids and neutral lipids
YDR279W 7.23
RNH202
Ribonuclease H2 subunit, required for RNase H2 activity
YMR083W 7.14
ADH3
Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production
YER131W 7.11
RPS26B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein
YMR106C 7.04
YKU80
Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
YKL096W-A 6.60
CWP2
Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored
YDR345C 6.59
HXT3
Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions
YDR385W 6.40
EFT2
Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin
YKR038C 6.19
KAE1
Putative glycoprotease proposed to be in transcription as a component of the EKC protein complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; also identified as a component of the KEOPS protein complex
YGL103W 6.18
RPL28
Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance
YOR272W 6.09
YTM1
Constituent of 66S pre-ribosomal particles, required for maturation of the large ribosomal subunit
YBL092W 6.06
RPL32
Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing
YER102W 6.04
RPS8B
Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein
YKR092C 5.96
SRP40
Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140
YLR167W 5.86
RPS31
Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B
YPR148C 5.81 Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YKL182W 5.67
FAS1
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities
YLR062C 5.55
BUD28
Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay
YGR145W 5.50
ENP2
Essential nucleolar protein of unknown function; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
YOR096W 5.50
RPS7A
Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins
YDR502C 5.42
SAM2
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p)
YKL063C 5.28 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
YKL081W 5.28
TEF4
Translation elongation factor EF-1 gamma
YHL003C 5.27
LAG1
Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p
YGL179C 5.24
TOS3
Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome
YMR290W-A 5.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase
YLR413W 5.23 Putative protein of unknown function; YLR413W is not an essential gene
YHR180W-A 5.20 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3
YDR509W 5.19 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YOR369C 5.18
RPS12
Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12
YHL015W 5.16
RPS20
Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins
YBR011C 5.12
IPP1
Cytoplasmic inorganic pyrophosphatase (PPase), catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase
YMR290C 5.12
HAS1
ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
YDR508C 4.98
GNP1
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids
YNL110C 4.88
NOP15
Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm
YAL038W 4.85
CDC19
Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration
YKL110C 4.81
KTI12
Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
YKL218C 4.77
SRY1
3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required for survival in the presence of hydroxyaspartate
YMR116C 4.75
ASC1
G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation
YLR183C 4.74
TOS4
Transcription factor that binds to a number of promoter regions, particularly promoters of some genes involved in pheromone response and cell cycle; potential Cdc28p substrate; expression is induced in G1 by bound SBF
YLR276C 4.71
DBP9
ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit
YOR271C 4.65
FSF1
Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis
YLL045C 4.65
RPL8B
Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits
YPL263C 4.65
KEL3
Cytoplasmic protein of unknown function
YLR185W 4.62
RPL37A
Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein
YGR052W 4.58
FMP48
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR126W-A 4.56 Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches
YNL113W 4.53
RPC19
RNA polymerase subunit, common to RNA polymerases I and III
YBR181C 4.52
RPS6B
Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein
YDL051W 4.48
LHP1
RNA binding protein required for maturation of tRNA and snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen
YMR183C 4.41
SSO2
Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p
YLR432W 4.39
IMD3
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed
YGR086C 4.39
PIL1
Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria
YDR447C 4.38
RPS17B
Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein
YJL136C 4.36
RPS21B
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein
YGR138C 4.34
TPO2
Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily
YOR309C 4.33 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
YDR384C 4.27
ATO3
Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters
YDL211C 4.26 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
YPL012W 4.18
RRP12
Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; contains HEAT-repeats
YGR040W 4.17
KSS1
Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains
YGR140W 4.13
CBF2
Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo
YAL033W 4.08
POP5
Subunit of both RNase MRP, which cleaves pre-rRNA, and nuclear RNase P, which cleaves tRNA precursors to generate mature 5' ends
YOL085C 4.07 Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A
YAL003W 4.05
EFB1
Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site
YNL112W 4.05
DBP2
Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing
YDR098C 4.00
GRX3
Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage
YIL056W 3.98
VHR1
Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations
YLR355C 3.95
ILV5
Acetohydroxyacid reductoisomerase, mitochondrial protein involved in branched-chain amino acid biosynthesis, also required for maintenance of wild-type mitochondrial DNA and found in mitochondrial nucleoids
YER073W 3.94
ALD5
Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed
YER137C 3.93 Putative protein of unknown function
YBR210W 3.92
ERV15
Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p
YDR101C 3.86
ARX1
Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
YDR450W 3.81
RPS18A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins
YJR097W 3.81
JJJ3
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YOR340C 3.81
RPA43
RNA polymerase I subunit A43
YGL209W 3.78
MIG2
Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter
YNL248C 3.72
RPA49
RNA polymerase I subunit A49
YDR144C 3.70
MKC7
GPI-anchored aspartyl protease (yapsin) involved in protein processing; shares functions with Yap3p and Kex2p
YOR234C 3.70
RPL33B
Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable
YDR382W 3.66
RPP2B
Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm
YCR031C 3.64
RPS14A
Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins
YBR143C 3.63
SUP45
Polypeptide release factor involved in translation termination; mutant form acts as a recessive omnipotent suppressor
YGR128C 3.62
UTP8
Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA
YGR050C 3.62 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR075W 3.62
RPL10
Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family
YEL053W-A 3.57 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C
YKL128C 3.56
PMU1
Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant
YIL052C 3.54
RPL34B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein
YGL055W 3.51
OLE1
Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria
YOR277C 3.50 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
YER136W 3.49
GDI1
GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
YGR187C 3.49
HGH1
Nonessential protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16)
YHR141C 3.47
RPL42B
Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus
YER134C 3.44 Putative protein of unknown function; non-essential gene
YJL148W 3.43
RPA34
RNA polymerase I subunit A34.5
YDL063C 3.42 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL063C is not an essential gene
YOR047C 3.42
STD1
Protein involved in control of glucose-regulated gene expression; interacts with protein kinase Snf1p, glucose sensors Snf3p and Rgt2p, and TATA-binding protein Spt15p; acts as a regulator of the transcription factor Rgt1p
YDL062W 3.41 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential
YGR264C 3.39
MES1
Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs
YLR150W 3.39
STM1
Protein that binds G4 quadruplex and purine motif triplex nucleic acid; acts with Cdc13p to maintain telomere structure; interacts with ribosomes and subtelomeric Y' DNA; multicopy suppressor of tom1 and pop2 mutations
YML075C 3.38
HMG1
One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae
YDR044W 3.36
HEM13
Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; localizes to the mitochondrial inner membrane; transcription is repressed by oxygen and heme (via Rox1p and Hap1p)
YGL123W 3.34
RPS2
Protein component of the small (40S) subunit, essential for control of translational accuracy; has similarity to E. coli S5 and rat S2 ribosomal proteins
YGL123C-A 3.34 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W
YML074C 3.32
FPR3
Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p
YOL093W 3.30
TRM10
tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs
YLR029C 3.29
RPL15A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA
YPL075W 3.29
GCR1
Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
YGR265W 3.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
YMR032W 3.28
HOF1
Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p
YNL231C 3.27
PDR16
Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p
YKL164C 3.26
PIR1
O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle
YGR027C 3.25
RPS25A
Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein
YDR278C 3.23 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YIL009W 3.23
FAA3
Long chain fatty acyl-CoA synthetase, has a preference for C16 and C18 fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
YGR036C 3.19
CAX4
Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation
YLR249W 3.19
YEF3
Translational elongation factor 3, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing EF-1 alpha from the ribosomal complex; contains two ABC cassettes; binds and hydrolyses ATP
YMR123W 3.19
PKR1
V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); overproduction confers resistance to Pichia farinosa killer toxin
YJL011C 3.18
RPC17
RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex
YER001W 3.16
MNN1
Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
YJR145C 3.15
RPS4A
Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein
YLR325C 3.13
RPL38
Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein
YIL078W 3.11
THS1
Threonyl-tRNA synthetase, essential cytoplasmic protein
YEL068C 3.11 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER070W 3.11
RNR1
One of two large regulatory subunits of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits
YGR051C 3.10 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene
YLR312W-A 3.09
MRPL15
Mitochondrial ribosomal protein of the large subunit
YIL069C 3.09
RPS24B
Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein
YKL078W 3.09
DHR2
Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis
YHR094C 3.07
HXT1
Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting
YKR074W 3.07
AIM29
Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; null mutant displays increased frequency of mitochondrial genome loss (petite formation)
YHR174W 3.06
ENO2
Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose
YJL162C 3.00
JJJ2
Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein
YJL177W 2.99
RPL17B
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins
YJL105W 2.98
SET4
Protein of unknown function, contains a SET domain
YOR051C 2.98 Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
YMR177W 2.95
MMT1
Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p
YGR148C 2.95
RPL24B
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate
YKR013W 2.95
PRY2
Protein of unknown function, has similarity to Pry1p and Pry3p and to the plant PR-1 class of pathogen related proteins
YPL131W 2.95
RPL5
Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly
YBR126C 2.93
TPS1
Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway
YJR123W 2.93
RPS5
Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins
YGR245C 2.92
SDA1
Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis
YOR004W 2.91
UTP23
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function
YHR216W 2.89
IMD2
Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitation
YER012W 2.87
PRE1
Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle
YDL136W 2.87
RPL35B
Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein
YPL062W 2.87 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation
YIL015W 2.86
BAR1
Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest
YGL147C 2.84
RPL9A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins
YKL180W 2.79
RPL17A
Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex)
YNR003C 2.79
RPC34
RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex
YGR285C 2.75
ZUO1
Cytosolic ribosome-associated chaperone that acts, together with Ssz1p and the Ssb proteins, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p
YOR206W 2.74
NOC2
Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors
YMR199W 2.74
CLN1
G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
YAL036C 2.74
RBG1
Member of the DRG family of GTP-binding proteins; interacts with translating ribosomes and with Tma46p
YIL118W 2.73
RHO3
Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p
YBR066C 2.72
NRG2
Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p
YFR054C 2.71 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YBR092C 2.71
PHO3
Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin
YPR163C 2.71
TIF3
Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA
YDR496C 2.70
PUF6
Pumilio-homology domain protein that binds ASH1 mRNA at PUF consensus sequences in the 3' UTR and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA
YMR082C 2.69 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
YER049W 2.67
TPA1
Protein of unknown function; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; has a role in translation termination efficiency, mRNA poly(A) tail length and mRNA stability
YGR106C 2.66
VOA1
Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar memebrane
YGR139W 2.66 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YEL001C 2.66
IRC22
Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
YNR054C 2.66
ESF2
Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome
YCR099C 2.65 Putative protein of unknown function
YDR454C 2.65
GUK1
Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins
YMR217W 2.65
GUA1
GMP synthase, an enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation
YOR342C 2.64 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YDR339C 2.63
FCF1
Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in the pre-rRNA processing steps of 40S ribosomal subunit biogenesis; contains a PINc domain; copurifies with Faf1p
YNR016C 2.63
ACC1
Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids
YPL238C 2.62 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W
YPL010W 2.59
RET3
Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
YKR026C 2.57
GCN3
Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression
YLR002C 2.57
NOC3
Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation

Network of associatons between targets according to the STRING database.

First level regulatory network of DOT6

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0000098 sulfur amino acid catabolic process(GO:0000098)
3.5 24.8 GO:0010696 positive regulation of spindle pole body separation(GO:0010696)
3.2 12.7 GO:0046898 response to organic cyclic compound(GO:0014070) response to cycloheximide(GO:0046898)
3.2 9.5 GO:0048024 regulation of RNA splicing(GO:0043484) regulation of mRNA splicing, via spliceosome(GO:0048024)
3.0 11.8 GO:0046500 S-adenosylmethionine metabolic process(GO:0046500)
2.9 8.7 GO:0044209 AMP salvage(GO:0044209)
2.8 8.5 GO:0007189 adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189)
2.7 13.7 GO:0006177 GMP biosynthetic process(GO:0006177)
2.7 8.2 GO:0019401 glycerol biosynthetic process(GO:0006114) alditol biosynthetic process(GO:0019401)
2.6 2.6 GO:0046037 GMP metabolic process(GO:0046037)
2.6 46.6 GO:0051029 rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029)
2.5 10.1 GO:0035337 fatty-acyl-CoA metabolic process(GO:0035337)
2.5 10.0 GO:0006361 transcription initiation from RNA polymerase I promoter(GO:0006361)
2.2 6.7 GO:0045901 positive regulation of translational elongation(GO:0045901)
2.2 4.4 GO:0000461 endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000461)
2.1 10.5 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.9 9.5 GO:0007535 donor selection(GO:0007535)
1.7 12.0 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
1.7 6.8 GO:0009240 isopentenyl diphosphate biosynthetic process(GO:0009240) isopentenyl diphosphate biosynthetic process, mevalonate pathway(GO:0019287) isopentenyl diphosphate metabolic process(GO:0046490)
1.7 23.3 GO:0000028 ribosomal small subunit assembly(GO:0000028)
1.6 200.5 GO:0002181 cytoplasmic translation(GO:0002181)
1.5 21.6 GO:0042790 transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790)
1.3 4.0 GO:0019673 GDP-mannose biosynthetic process(GO:0009298) GDP-mannose metabolic process(GO:0019673)
1.3 5.2 GO:0000296 spermine transport(GO:0000296)
1.3 5.2 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
1.3 3.8 GO:0072361 regulation of glycolytic process by regulation of transcription from RNA polymerase II promoter(GO:0072361) regulation of glycolytic process by positive regulation of transcription from RNA polymerase II promoter(GO:0072363)
1.2 3.7 GO:0061422 positive regulation of transcription from RNA polymerase II promoter in response to alkaline pH(GO:0061422)
1.2 1.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
1.2 3.5 GO:0070637 nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637)
1.1 1.1 GO:0009265 pyrimidine deoxyribonucleotide metabolic process(GO:0009219) pyrimidine deoxyribonucleotide biosynthetic process(GO:0009221) 2'-deoxyribonucleotide biosynthetic process(GO:0009265) 2'-deoxyribonucleotide metabolic process(GO:0009394) deoxyribose phosphate biosynthetic process(GO:0046385)
1.1 4.5 GO:0036170 filamentous growth of a population of unicellular organisms in response to starvation(GO:0036170) regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900434) positive regulation of filamentous growth of a population of unicellular organisms in response to starvation(GO:1900436)
1.1 19.9 GO:0009304 tRNA transcription(GO:0009304) tRNA transcription from RNA polymerase III promoter(GO:0042797)
1.1 7.7 GO:0046501 protoporphyrinogen IX biosynthetic process(GO:0006782) protoporphyrinogen IX metabolic process(GO:0046501)
1.1 4.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
1.1 27.5 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
1.1 3.2 GO:0034471 rRNA 5'-end processing(GO:0000967) ncRNA 5'-end processing(GO:0034471)
1.1 3.2 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636) unsaturated fatty acid metabolic process(GO:0033559)
1.0 5.2 GO:0045947 negative regulation of translational initiation(GO:0045947)
1.0 4.1 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211)
1.0 6.1 GO:0009099 valine biosynthetic process(GO:0009099)
1.0 3.0 GO:0043171 peptide catabolic process(GO:0043171)
1.0 65.1 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
1.0 12.0 GO:0006415 translational termination(GO:0006415)
1.0 6.0 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
1.0 3.0 GO:0038032 termination of signal transduction(GO:0023021) termination of G-protein coupled receptor signaling pathway(GO:0038032)
0.9 2.8 GO:1902223 L-phenylalanine biosynthetic process(GO:0009094) erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process(GO:1902223)
0.9 2.8 GO:0046416 D-amino acid metabolic process(GO:0046416)
0.9 9.3 GO:0006116 NADH oxidation(GO:0006116)
0.9 3.7 GO:0006528 asparagine metabolic process(GO:0006528)
0.9 28.3 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.9 2.7 GO:0043069 negative regulation of apoptotic process(GO:0043066) negative regulation of programmed cell death(GO:0043069) negative regulation of cell death(GO:0060548)
0.9 7.2 GO:0000372 Group I intron splicing(GO:0000372) RNA splicing, via transesterification reactions with guanosine as nucleophile(GO:0000376)
0.9 24.3 GO:0033753 ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428)
0.9 1.7 GO:0031684 heterotrimeric G-protein complex cycle(GO:0031684)
0.9 1.7 GO:0033262 regulation of nuclear cell cycle DNA replication(GO:0033262)
0.9 6.0 GO:0005992 trehalose biosynthetic process(GO:0005992) oligosaccharide biosynthetic process(GO:0009312) disaccharide biosynthetic process(GO:0046351)
0.8 3.3 GO:0000092 mitotic anaphase B(GO:0000092)
0.8 14.0 GO:0030488 tRNA methylation(GO:0030488)
0.8 9.4 GO:0034963 box C/D snoRNA metabolic process(GO:0033967) box C/D snoRNA processing(GO:0034963)
0.8 8.6 GO:0045053 protein retention in Golgi apparatus(GO:0045053)
0.8 2.3 GO:0019413 acetate biosynthetic process(GO:0019413)
0.8 4.6 GO:0006491 N-glycan processing(GO:0006491)
0.8 2.3 GO:0019419 sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)(GO:0019379) sulfate reduction(GO:0019419)
0.8 11.3 GO:0071047 nuclear polyadenylation-dependent mRNA catabolic process(GO:0071042) polyadenylation-dependent mRNA catabolic process(GO:0071047)
0.7 1.5 GO:0046083 adenine metabolic process(GO:0046083)
0.7 0.7 GO:0015833 peptide transport(GO:0015833)
0.7 2.9 GO:0002143 tRNA wobble position uridine thiolation(GO:0002143)
0.7 5.1 GO:0006672 ceramide metabolic process(GO:0006672) ceramide biosynthetic process(GO:0046513)
0.7 2.2 GO:0071545 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855) inositol phosphate catabolic process(GO:0071545)
0.7 3.6 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.7 5.6 GO:0042219 cellular modified amino acid catabolic process(GO:0042219)
0.7 3.5 GO:0032231 regulation of actin filament bundle assembly(GO:0032231) positive regulation of actin filament bundle assembly(GO:0032233)
0.7 10.4 GO:0001100 negative regulation of exit from mitosis(GO:0001100)
0.7 4.0 GO:0009088 threonine biosynthetic process(GO:0009088)
0.7 1.3 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.7 3.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
0.7 3.3 GO:0000162 tryptophan biosynthetic process(GO:0000162) indole-containing compound biosynthetic process(GO:0042435) indolalkylamine biosynthetic process(GO:0046219)
0.6 1.9 GO:0035953 regulation of oligopeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035950) negative regulation of oligopeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035952) regulation of dipeptide transport by regulation of transcription from RNA polymerase II promoter(GO:0035953) negative regulation of dipeptide transport by negative regulation of transcription from RNA polymerase II promoter(GO:0035955) negative regulation of oligopeptide transport(GO:2000877) negative regulation of dipeptide transport(GO:2000879)
0.6 1.3 GO:0046831 regulation of mRNA export from nucleus(GO:0010793) regulation of nucleobase-containing compound transport(GO:0032239) regulation of RNA export from nucleus(GO:0046831) regulation of ribonucleoprotein complex localization(GO:2000197)
0.6 5.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.6 2.5 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)
0.6 2.4 GO:0009423 chorismate biosynthetic process(GO:0009423)
0.6 1.2 GO:0009186 deoxyribonucleoside diphosphate metabolic process(GO:0009186)
0.6 4.7 GO:0000022 mitotic spindle elongation(GO:0000022) spindle elongation(GO:0051231)
0.6 1.2 GO:0000751 mitotic cell cycle arrest in response to pheromone(GO:0000751) mitotic cell cycle arrest(GO:0071850)
0.6 2.3 GO:0000771 agglutination involved in conjugation with cellular fusion(GO:0000752) agglutination involved in conjugation(GO:0000771) heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) cell-cell adhesion(GO:0098609) adhesion between unicellular organisms(GO:0098610) multi organism cell adhesion(GO:0098740) cell-cell adhesion via plasma-membrane adhesion molecules(GO:0098742)
0.6 1.1 GO:0006047 UDP-N-acetylglucosamine metabolic process(GO:0006047) UDP-N-acetylglucosamine biosynthetic process(GO:0006048)
0.6 2.2 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.6 5.0 GO:0006797 polyphosphate metabolic process(GO:0006797)
0.6 0.6 GO:0040031 snRNA pseudouridine synthesis(GO:0031120) snRNA modification(GO:0040031)
0.6 1.1 GO:0016078 tRNA catabolic process(GO:0016078) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038)
0.5 2.2 GO:0042710 biofilm formation(GO:0042710)
0.5 4.4 GO:0070525 tRNA threonylcarbamoyladenosine metabolic process(GO:0070525)
0.5 1.1 GO:0051668 localization within membrane(GO:0051668)
0.5 1.6 GO:0015693 magnesium ion transport(GO:0015693)
0.5 1.6 GO:0031384 regulation of initiation of mating projection growth(GO:0031384)
0.5 2.1 GO:0031565 obsolete cytokinesis checkpoint(GO:0031565)
0.5 2.6 GO:0043433 negative regulation of sequence-specific DNA binding transcription factor activity(GO:0043433)
0.5 32.4 GO:0006364 rRNA processing(GO:0006364)
0.5 2.1 GO:0030497 fatty acid elongation(GO:0030497)
0.5 12.7 GO:0006334 nucleosome assembly(GO:0006334)
0.5 2.0 GO:0060277 obsolete negative regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0060277)
0.5 1.0 GO:0031111 negative regulation of microtubule depolymerization(GO:0007026) negative regulation of microtubule polymerization or depolymerization(GO:0031111) regulation of microtubule depolymerization(GO:0031114)
0.5 12.6 GO:0006096 glycolytic process(GO:0006096) ATP generation from ADP(GO:0006757)
0.5 1.5 GO:0001015 snoRNA transcription from an RNA polymerase II promoter(GO:0001015)
0.5 1.0 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.5 1.5 GO:0044819 mitotic G1 DNA damage checkpoint(GO:0031571) mitotic G1/S transition checkpoint(GO:0044819)
0.5 6.3 GO:0043094 cellular metabolic compound salvage(GO:0043094)
0.5 2.9 GO:0042274 ribosomal small subunit biogenesis(GO:0042274)
0.5 1.9 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.5 5.2 GO:0017148 negative regulation of translation(GO:0017148) negative regulation of cellular amide metabolic process(GO:0034249)
0.5 1.4 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900) tetrahydrofolylpolyglutamate biosynthetic process(GO:0046901)
0.5 7.5 GO:0032508 DNA duplex unwinding(GO:0032508)
0.5 1.9 GO:0042990 regulation of transcription factor import into nucleus(GO:0042990)
0.5 1.4 GO:0045337 terpenoid metabolic process(GO:0006721) terpenoid biosynthetic process(GO:0016114) farnesyl diphosphate biosynthetic process(GO:0045337) farnesyl diphosphate metabolic process(GO:0045338)
0.5 1.4 GO:0070676 intralumenal vesicle formation(GO:0070676)
0.5 12.7 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.4 4.5 GO:0007109 obsolete cytokinesis, completion of separation(GO:0007109)
0.4 4.4 GO:0006446 regulation of translational initiation(GO:0006446)
0.4 2.6 GO:0070941 eisosome assembly(GO:0070941)
0.4 6.5 GO:0006037 cell wall chitin metabolic process(GO:0006037)
0.4 0.9 GO:1902931 negative regulation of alcohol biosynthetic process(GO:1902931)
0.4 1.3 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196) peptidyl-methionine modification(GO:0018206)
0.4 0.4 GO:0033239 negative regulation of cellular amine metabolic process(GO:0033239)
0.4 2.1 GO:0046656 folic acid metabolic process(GO:0046655) folic acid biosynthetic process(GO:0046656)
0.4 0.9 GO:0006657 CDP-choline pathway(GO:0006657)
0.4 4.2 GO:0007021 tubulin complex assembly(GO:0007021)
0.4 0.8 GO:0009847 spore germination(GO:0009847)
0.4 5.8 GO:0002098 tRNA wobble base modification(GO:0002097) tRNA wobble uridine modification(GO:0002098)
0.4 2.8 GO:0006272 leading strand elongation(GO:0006272)
0.4 1.2 GO:0018216 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.4 2.8 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.4 1.2 GO:0010674 negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle(GO:0010674)
0.4 2.0 GO:0009098 leucine biosynthetic process(GO:0009098)
0.4 1.6 GO:0051090 regulation of sequence-specific DNA binding transcription factor activity(GO:0051090)
0.4 0.8 GO:0034033 coenzyme A biosynthetic process(GO:0015937) nucleoside bisphosphate biosynthetic process(GO:0033866) ribonucleoside bisphosphate biosynthetic process(GO:0034030) purine nucleoside bisphosphate biosynthetic process(GO:0034033)
0.4 1.1 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.4 11.2 GO:0006487 protein N-linked glycosylation(GO:0006487)
0.4 1.5 GO:0060188 regulation of protein desumoylation(GO:0060188)
0.4 1.1 GO:0042780 tRNA 3'-end processing(GO:0042780)
0.4 10.7 GO:0016126 steroid biosynthetic process(GO:0006694) sterol biosynthetic process(GO:0016126)
0.4 1.8 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.3 0.3 GO:0009202 deoxyribonucleoside triphosphate metabolic process(GO:0009200) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.3 10.5 GO:0008033 tRNA processing(GO:0008033)
0.3 2.8 GO:0051598 meiotic cell cycle checkpoint(GO:0033313) meiotic recombination checkpoint(GO:0051598)
0.3 0.3 GO:0042304 regulation of fatty acid biosynthetic process(GO:0042304)
0.3 2.0 GO:0031134 sister chromatid biorientation(GO:0031134)
0.3 3.7 GO:0007120 axial cellular bud site selection(GO:0007120)
0.3 1.0 GO:0045896 regulation of transcription during mitosis(GO:0045896)
0.3 0.7 GO:0007234 osmosensory signaling via phosphorelay pathway(GO:0007234)
0.3 1.7 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.3 5.2 GO:0006414 translational elongation(GO:0006414)
0.3 1.3 GO:0006814 sodium ion transport(GO:0006814)
0.3 0.6 GO:0070827 chromatin maintenance(GO:0070827)
0.3 1.3 GO:0070868 heterochromatin organization involved in chromatin silencing(GO:0070868) chromatin organization involved in negative regulation of transcription(GO:0097549)
0.3 0.3 GO:0031555 regulation of DNA-templated transcription, termination(GO:0031554) transcriptional attenuation(GO:0031555) transcription antitermination(GO:0031564)
0.3 3.1 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529)
0.3 4.3 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.3 0.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 0.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.3 2.0 GO:0006611 protein export from nucleus(GO:0006611)
0.3 2.0 GO:0007000 nucleolus organization(GO:0007000)
0.3 7.4 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.3 0.8 GO:0006566 threonine metabolic process(GO:0006566)
0.3 1.7 GO:0045116 protein neddylation(GO:0045116)
0.3 0.3 GO:0034398 telomere tethering at nuclear periphery(GO:0034398)
0.3 0.8 GO:0048313 Golgi inheritance(GO:0048313)
0.3 1.4 GO:0090158 regulation of phosphatidylinositol dephosphorylation(GO:0060304) endoplasmic reticulum membrane organization(GO:0090158)
0.3 1.6 GO:0061572 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)
0.3 2.4 GO:0006273 lagging strand elongation(GO:0006273)
0.3 1.5 GO:0000743 nuclear migration involved in conjugation with cellular fusion(GO:0000743)
0.3 1.3 GO:1903338 regulation of cell wall organization or biogenesis(GO:1903338)
0.2 0.7 GO:0051597 response to methylmercury(GO:0051597) cellular response to methylmercury(GO:0071406)
0.2 5.9 GO:1904029 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.2 5.0 GO:0006413 translational initiation(GO:0006413)
0.2 0.5 GO:0000011 vacuole inheritance(GO:0000011)
0.2 0.2 GO:0006531 aspartate metabolic process(GO:0006531)
0.2 0.7 GO:0000348 mRNA branch site recognition(GO:0000348)
0.2 0.4 GO:0015786 pyrimidine nucleotide-sugar transport(GO:0015781) UDP-glucose transport(GO:0015786)
0.2 0.2 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
0.2 0.4 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.2 0.2 GO:0048211 Golgi vesicle docking(GO:0048211)
0.2 1.3 GO:0019344 cysteine biosynthetic process(GO:0019344)
0.2 14.1 GO:0006913 nucleocytoplasmic transport(GO:0006913)
0.2 1.0 GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition(GO:0006617)
0.2 1.2 GO:0048478 replication fork protection(GO:0048478)
0.2 0.6 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 1.6 GO:0009303 rRNA transcription(GO:0009303)
0.2 0.8 GO:0007009 plasma membrane organization(GO:0007009)
0.2 0.8 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.2 0.9 GO:0000032 cell wall mannoprotein biosynthetic process(GO:0000032) mannoprotein metabolic process(GO:0006056) mannoprotein biosynthetic process(GO:0006057) cell wall glycoprotein biosynthetic process(GO:0031506)
0.2 0.2 GO:0016320 endoplasmic reticulum membrane fusion(GO:0016320)
0.2 1.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.2 0.2 GO:0047484 regulation of response to osmotic stress(GO:0047484)
0.2 1.2 GO:0006857 oligopeptide transport(GO:0006857)
0.2 0.5 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
0.2 0.5 GO:0036213 actomyosin contractile ring contraction(GO:0000916) contractile ring contraction(GO:0036213)
0.2 4.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.2 1.2 GO:0007323 peptide pheromone maturation(GO:0007323)
0.2 0.3 GO:0000957 mitochondrial RNA catabolic process(GO:0000957)
0.2 0.8 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.2 0.6 GO:0015883 FAD transport(GO:0015883)
0.2 1.6 GO:0051028 mRNA transport(GO:0051028)
0.2 1.6 GO:0006972 hyperosmotic response(GO:0006972)
0.2 0.5 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.2 0.6 GO:0006469 negative regulation of protein kinase activity(GO:0006469)
0.2 0.5 GO:1900101 regulation of endoplasmic reticulum unfolded protein response(GO:1900101)
0.1 0.1 GO:0033241 regulation of cellular amine catabolic process(GO:0033241)
0.1 0.7 GO:0010520 regulation of reciprocal meiotic recombination(GO:0010520)
0.1 0.1 GO:0031365 N-terminal protein amino acid modification(GO:0031365)
0.1 0.1 GO:2001021 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.1 0.6 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
0.1 0.3 GO:0015780 nucleotide-sugar transport(GO:0015780)
0.1 0.6 GO:0032272 negative regulation of actin filament polymerization(GO:0030837) negative regulation of protein polymerization(GO:0032272)
0.1 0.8 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.1 1.9 GO:0006360 transcription from RNA polymerase I promoter(GO:0006360)
0.1 1.2 GO:0006379 mRNA cleavage(GO:0006379)
0.1 0.5 GO:0016036 cellular response to phosphate starvation(GO:0016036)
0.1 0.5 GO:0006720 isoprenoid metabolic process(GO:0006720) isoprenoid biosynthetic process(GO:0008299)
0.1 1.6 GO:0006337 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.1 0.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.1 0.9 GO:0010970 establishment of localization by movement along microtubule(GO:0010970) nuclear migration along microtubule(GO:0030473) organelle transport along microtubule(GO:0072384)
0.1 0.3 GO:1903530 regulation of exocytosis(GO:0017157) regulation of secretion(GO:0051046) regulation of secretion by cell(GO:1903530)
0.1 0.3 GO:0006816 calcium ion transport(GO:0006816)
0.1 0.9 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.1 2.2 GO:0015918 sterol transport(GO:0015918)
0.1 1.4 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.1 0.8 GO:0032042 mitochondrial DNA metabolic process(GO:0032042)
0.1 0.5 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.3 GO:0007050 cell cycle arrest(GO:0007050)
0.1 0.5 GO:0044070 regulation of anion transport(GO:0044070)
0.1 1.9 GO:0046785 microtubule nucleation(GO:0007020) microtubule polymerization(GO:0046785)
0.1 0.7 GO:0009306 protein secretion(GO:0009306)
0.1 0.3 GO:0051176 regulation of vitamin metabolic process(GO:0030656) positive regulation of vitamin metabolic process(GO:0046136) positive regulation of sulfur metabolic process(GO:0051176) regulation of thiamine biosynthetic process(GO:0070623) positive regulation of thiamine biosynthetic process(GO:0090180)
0.1 0.9 GO:0031110 regulation of microtubule polymerization or depolymerization(GO:0031110)
0.1 0.9 GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146)
0.1 1.5 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 0.1 GO:0034517 ribophagy(GO:0034517)
0.1 1.4 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.1 0.5 GO:0030011 maintenance of cell polarity(GO:0030011)
0.1 0.6 GO:0016233 telomere capping(GO:0016233)
0.1 0.4 GO:0036010 protein localization to endosome(GO:0036010)
0.1 0.6 GO:0006855 drug transmembrane transport(GO:0006855)
0.1 0.5 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 2.2 GO:0045324 late endosome to vacuole transport(GO:0045324)
0.1 0.4 GO:0015867 ATP transport(GO:0015867)
0.1 4.4 GO:0016311 dephosphorylation(GO:0016311)
0.1 0.2 GO:0071072 negative regulation of phospholipid biosynthetic process(GO:0071072) negative regulation of phospholipid metabolic process(GO:1903726)
0.1 0.2 GO:0060988 lipid tube assembly(GO:0060988) protein-lipid complex assembly(GO:0065005) protein-lipid complex subunit organization(GO:0071825)
0.1 0.1 GO:0071482 cellular response to radiation(GO:0071478) cellular response to light stimulus(GO:0071482)
0.1 0.3 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.1 1.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.1 0.2 GO:0042256 mature ribosome assembly(GO:0042256)
0.1 0.3 GO:0055129 L-proline biosynthetic process(GO:0055129)
0.1 0.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.1 0.4 GO:0035999 tetrahydrofolate interconversion(GO:0035999)
0.1 0.1 GO:0006734 NADH metabolic process(GO:0006734)
0.1 0.5 GO:0070481 nuclear-transcribed mRNA catabolic process, non-stop decay(GO:0070481)
0.1 0.2 GO:0000388 spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)(GO:0000388)
0.1 0.2 GO:0031047 gene silencing involved in chronological cell aging(GO:0010978) gene silencing by RNA(GO:0031047)
0.1 0.1 GO:0042762 regulation of sulfur metabolic process(GO:0042762)
0.1 1.2 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.1 0.6 GO:0015988 energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662)
0.1 0.2 GO:0040023 nuclear migration(GO:0007097) establishment of nucleus localization(GO:0040023) nucleus localization(GO:0051647)
0.1 0.2 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.1 0.5 GO:0006547 histidine biosynthetic process(GO:0000105) histidine metabolic process(GO:0006547) imidazole-containing compound metabolic process(GO:0052803)
0.1 0.2 GO:0090110 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.3 GO:0097354 protein prenylation(GO:0018342) prenylation(GO:0097354)
0.1 0.1 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.2 GO:0009371 positive regulation of transcription from RNA polymerase II promoter by pheromones(GO:0007329) positive regulation of transcription by pheromones(GO:0009371)
0.1 1.8 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 0.2 GO:0016197 endosomal transport(GO:0016197)
0.0 0.7 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.0 0.1 GO:0009185 purine nucleoside diphosphate metabolic process(GO:0009135) purine ribonucleoside diphosphate metabolic process(GO:0009179) ribonucleoside diphosphate metabolic process(GO:0009185) ADP metabolic process(GO:0046031)
0.0 0.1 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0 0.0 GO:0006399 tRNA metabolic process(GO:0006399)
0.0 0.2 GO:0042401 amine biosynthetic process(GO:0009309) cellular biogenic amine biosynthetic process(GO:0042401)
0.0 0.1 GO:0006784 heme a biosynthetic process(GO:0006784) heme a metabolic process(GO:0046160)
0.0 0.1 GO:0001174 DNA-templated transcriptional start site selection(GO:0001173) transcriptional start site selection at RNA polymerase II promoter(GO:0001174)
0.0 0.4 GO:0040020 regulation of meiotic nuclear division(GO:0040020) regulation of meiotic cell cycle(GO:0051445)
0.0 0.2 GO:0043007 maintenance of rDNA(GO:0043007)
0.0 0.3 GO:0006885 regulation of pH(GO:0006885)
0.0 0.2 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.0 0.2 GO:0043687 C-terminal protein amino acid modification(GO:0018410) post-translational protein modification(GO:0043687)
0.0 0.2 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.0 0.3 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.0 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.0 GO:0045833 negative regulation of lipid metabolic process(GO:0045833)
0.0 0.1 GO:0006517 protein deglycosylation(GO:0006517)
0.0 0.3 GO:0031570 DNA integrity checkpoint(GO:0031570)
0.0 0.0 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.1 GO:0009452 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
0.0 0.0 GO:0000084 mitotic S phase(GO:0000084) S phase(GO:0051320)
0.0 0.0 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719) negative regulation of glycogen metabolic process(GO:0070874)
0.0 0.0 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.3 GO:0006896 Golgi to vacuole transport(GO:0006896)
0.0 0.1 GO:0006526 arginine biosynthetic process(GO:0006526)
0.0 0.1 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 9.8 GO:0070545 PeBoW complex(GO:0070545)
3.2 9.5 GO:0032299 ribonuclease H2 complex(GO:0032299)
2.7 8.1 GO:0005854 nascent polypeptide-associated complex(GO:0005854)
2.4 9.5 GO:0070860 RNA polymerase I core factor complex(GO:0070860)
2.3 32.2 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
2.1 10.7 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
2.1 126.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
2.0 165.8 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
2.0 9.9 GO:0030689 Noc complex(GO:0030689)
1.8 8.8 GO:0000408 EKC/KEOPS complex(GO:0000408)
1.7 5.2 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.3 8.8 GO:0034455 t-UTP complex(GO:0034455)
1.2 5.0 GO:0031428 box C/D snoRNP complex(GO:0031428)
1.2 4.9 GO:0031429 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
1.2 3.6 GO:0017102 methionyl glutamyl tRNA synthetase complex(GO:0017102)
1.2 3.5 GO:0097344 Rix1 complex(GO:0097344)
1.1 4.5 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
1.1 4.5 GO:0042788 polysomal ribosome(GO:0042788)
1.0 39.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
1.0 24.0 GO:0032040 small-subunit processome(GO:0032040)
0.9 9.1 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.9 4.4 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.9 2.6 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.8 3.4 GO:0044697 HICS complex(GO:0044697)
0.8 21.6 GO:0030686 90S preribosome(GO:0030686)
0.8 6.5 GO:0005720 nuclear heterochromatin(GO:0005720) nuclear telomeric heterochromatin(GO:0005724) telomeric heterochromatin(GO:0031933)
0.8 0.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.8 7.1 GO:0030681 nucleolar ribonuclease P complex(GO:0005655) multimeric ribonuclease P complex(GO:0030681)
0.8 10.9 GO:0000786 nucleosome(GO:0000786)
0.7 4.5 GO:0005880 nuclear microtubule(GO:0005880)
0.7 3.0 GO:0031518 CBF3 complex(GO:0031518)
0.7 6.0 GO:0042597 periplasmic space(GO:0042597)
0.7 4.4 GO:0043527 tRNA methyltransferase complex(GO:0043527)
0.7 4.4 GO:0032126 eisosome(GO:0032126)
0.7 3.6 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.7 2.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.7 2.8 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.7 11.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.7 77.3 GO:0005730 nucleolus(GO:0005730)
0.6 2.6 GO:0043614 multi-eIF complex(GO:0043614)
0.6 1.9 GO:0043529 GET complex(GO:0043529)
0.6 0.6 GO:0000145 exocyst(GO:0000145)
0.6 2.3 GO:0033254 vacuolar transporter chaperone complex(GO:0033254)
0.6 1.7 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.6 1.7 GO:0071261 Ssh1 translocon complex(GO:0071261)
0.5 2.6 GO:0005871 kinesin complex(GO:0005871)
0.5 1.5 GO:0070939 Dsl1p complex(GO:0070939)
0.5 11.2 GO:0031228 integral component of Golgi membrane(GO:0030173) intrinsic component of Golgi membrane(GO:0031228)
0.5 2.4 GO:0031391 Elg1 RFC-like complex(GO:0031391)
0.5 2.4 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
0.5 1.9 GO:0033597 mitotic checkpoint complex(GO:0033597)
0.5 3.3 GO:0016272 prefoldin complex(GO:0016272)
0.5 3.2 GO:0033180 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) proton-transporting V-type ATPase, V1 domain(GO:0033180)
0.5 1.4 GO:0000176 nuclear exosome (RNase complex)(GO:0000176)
0.4 1.8 GO:0034518 RNA cap binding complex(GO:0034518)
0.4 0.4 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.4 3.0 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.4 1.2 GO:0070985 TFIIK complex(GO:0070985)
0.4 6.5 GO:0022626 cytosolic ribosome(GO:0022626)
0.4 2.4 GO:0042555 MCM complex(GO:0042555)
0.4 3.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.4 2.0 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) SPOTS complex(GO:0035339)
0.4 5.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.4 1.2 GO:0097255 R2TP complex(GO:0097255)
0.4 3.4 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.4 1.4 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.4 1.8 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.4 1.1 GO:0030428 cell septum(GO:0030428)
0.3 1.4 GO:0044611 nuclear pore inner ring(GO:0044611)
0.3 1.4 GO:0000815 ESCRT III complex(GO:0000815)
0.3 1.7 GO:0000133 polarisome(GO:0000133)
0.3 1.0 GO:0005662 DNA replication factor A complex(GO:0005662)
0.3 1.3 GO:0034990 mitotic cohesin complex(GO:0030892) nuclear mitotic cohesin complex(GO:0034990)
0.3 4.7 GO:0005940 septin ring(GO:0005940)
0.3 1.7 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.3 0.7 GO:0000792 heterochromatin(GO:0000792)
0.3 1.0 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.3 12.0 GO:0005811 lipid particle(GO:0005811)
0.3 0.6 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.3 1.9 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.3 0.9 GO:0000229 cytoplasmic chromosome(GO:0000229) mitochondrial chromosome(GO:0000262)
0.3 2.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 3.5 GO:0034399 nuclear periphery(GO:0034399)
0.3 1.1 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
0.3 1.4 GO:0005786 signal recognition particle, endoplasmic reticulum targeting(GO:0005786) signal recognition particle(GO:0048500)
0.3 0.8 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 2.4 GO:0000243 commitment complex(GO:0000243)
0.3 0.8 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.3 1.8 GO:0005884 actin filament(GO:0005884)
0.3 7.6 GO:0030134 ER to Golgi transport vesicle(GO:0030134)
0.3 1.0 GO:0000938 GARP complex(GO:0000938)
0.3 2.1 GO:0030008 TRAPP complex(GO:0030008)
0.3 0.8 GO:0000928 gamma-tubulin small complex, spindle pole body(GO:0000928) gamma-tubulin complex(GO:0000930) gamma-tubulin small complex(GO:0008275)
0.2 1.0 GO:0030123 AP-3 adaptor complex(GO:0030123)
0.2 4.9 GO:0005844 polysome(GO:0005844)
0.2 1.2 GO:0034044 exomer complex(GO:0034044)
0.2 1.0 GO:0030906 retromer, cargo-selective complex(GO:0030906)
0.2 3.8 GO:0046695 SLIK (SAGA-like) complex(GO:0046695)
0.2 0.9 GO:0032432 actin filament bundle(GO:0032432)
0.2 0.9 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.2 7.5 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 2.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.2 1.6 GO:0000346 transcription export complex(GO:0000346)
0.2 35.1 GO:0005933 cellular bud(GO:0005933)
0.2 0.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.2 1.9 GO:0036452 ESCRT complex(GO:0036452)
0.2 0.6 GO:0005823 central plaque of spindle pole body(GO:0005823)
0.2 0.6 GO:0042575 DNA polymerase complex(GO:0042575)
0.2 3.6 GO:0016586 RSC complex(GO:0016586)
0.2 1.0 GO:0005641 nuclear envelope lumen(GO:0005641)
0.2 0.8 GO:0030907 MBF transcription complex(GO:0030907)
0.2 1.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 0.4 GO:0000131 incipient cellular bud site(GO:0000131)
0.2 2.5 GO:0030133 transport vesicle(GO:0030133)
0.2 1.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.2 0.8 GO:0070775 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.2 0.7 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
0.2 1.3 GO:0000439 core TFIIH complex(GO:0000439)
0.2 0.9 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.2 0.7 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 1.9 GO:0005685 U1 snRNP(GO:0005685)
0.2 3.6 GO:0044445 cytosolic part(GO:0044445)
0.2 1.1 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
0.2 0.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.2 0.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.2 2.0 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 1.0 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 0.8 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 0.4 GO:0035649 Nrd1 complex(GO:0035649)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 0.2 GO:0016459 myosin complex(GO:0016459)
0.1 0.5 GO:0031502 dolichyl-phosphate-mannose-protein mannosyltransferase complex(GO:0031502)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 0.3 GO:0033186 CAF-1 complex(GO:0033186)
0.1 0.7 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 0.9 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.1 0.8 GO:0017119 Golgi transport complex(GO:0017119)
0.1 0.7 GO:0072686 mitotic spindle(GO:0072686)
0.1 0.1 GO:0005688 U6 snRNP(GO:0005688)
0.1 1.0 GO:0031261 DNA replication preinitiation complex(GO:0031261)
0.1 0.2 GO:0000798 nuclear cohesin complex(GO:0000798) cohesin complex(GO:0008278)
0.1 1.0 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.3 GO:0046930 pore complex(GO:0046930)
0.1 0.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 0.5 GO:0070772 PAS complex(GO:0070772)
0.1 0.1 GO:0044453 nuclear membrane part(GO:0044453)
0.1 0.2 GO:0000137 Golgi cis cisterna(GO:0000137)
0.1 0.1 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
0.1 0.3 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
0.1 0.3 GO:0033179 vacuolar proton-transporting V-type ATPase, V0 domain(GO:0000220) proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.5 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.1 0.2 GO:0070823 HDA1 complex(GO:0070823)
0.1 0.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 1.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 1.9 GO:0005643 nuclear pore(GO:0005643)
0.1 0.6 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.1 5.6 GO:0005840 ribosome(GO:0005840)
0.0 0.6 GO:0005686 U2 snRNP(GO:0005686)
0.0 0.2 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.0 0.1 GO:0042729 DASH complex(GO:0042729)
0.0 0.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 0.2 GO:0001401 mitochondrial sorting and assembly machinery complex(GO:0001401)
0.0 0.1 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.0 0.2 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.1 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.0 GO:0005828 kinetochore microtubule(GO:0005828)
0.0 0.0 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
0.0 0.1 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.0 0.1 GO:0005787 signal peptidase complex(GO:0005787)
0.0 0.1 GO:0055087 Ski complex(GO:0055087)
0.0 0.1 GO:0005967 mitochondrial pyruvate dehydrogenase complex(GO:0005967) pyruvate dehydrogenase complex(GO:0045254)
0.0 0.0 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.1 GO:0044815 DNA packaging complex(GO:0044815)
0.0 0.0 GO:0016587 Isw1 complex(GO:0016587)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.1 GO:0001169 transcription factor activity, RNA polymerase I CORE element sequence-specific binding(GO:0001169) transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting(GO:0001187)
3.0 9.0 GO:0003938 IMP dehydrogenase activity(GO:0003938)
2.7 10.9 GO:0019206 nucleoside kinase activity(GO:0019206)
2.7 2.7 GO:0097617 RNA strand annealing activity(GO:0033592) annealing activity(GO:0097617)
2.4 9.6 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
2.3 32.2 GO:0001054 RNA polymerase I activity(GO:0001054)
2.3 13.7 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
2.2 6.5 GO:0008097 5S rRNA binding(GO:0008097)
2.1 10.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
2.1 8.4 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
2.0 10.0 GO:0036002 pre-mRNA binding(GO:0036002)
1.8 10.7 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
1.7 1.7 GO:0004805 trehalose-phosphatase activity(GO:0004805)
1.4 4.2 GO:0019003 GDP binding(GO:0019003)
1.4 5.6 GO:0016841 ammonia-lyase activity(GO:0016841)
1.3 5.3 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.3 4.0 GO:0042134 rRNA primary transcript binding(GO:0042134)
1.3 4.0 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
1.3 1.3 GO:0015248 sterol transporter activity(GO:0015248)
1.3 5.2 GO:0000297 spermine transmembrane transporter activity(GO:0000297)
1.2 49.7 GO:0019843 rRNA binding(GO:0019843)
1.2 217.7 GO:0003735 structural constituent of ribosome(GO:0003735)
1.2 4.7 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
1.2 7.0 GO:0016408 C-acyltransferase activity(GO:0016408)
1.2 5.8 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
1.2 9.2 GO:0016423 tRNA (guanine) methyltransferase activity(GO:0016423)
1.1 4.6 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
1.1 4.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
1.1 29.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
1.1 18.6 GO:0030515 snoRNA binding(GO:0030515)
1.1 8.6 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
1.1 4.2 GO:0008172 S-methyltransferase activity(GO:0008172)
1.0 4.2 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
1.0 3.1 GO:0015166 polyol transmembrane transporter activity(GO:0015166)
1.0 3.1 GO:0016504 peptidase activator activity(GO:0016504)
1.0 5.1 GO:0004707 MAP kinase activity(GO:0004707)
1.0 1.0 GO:0001082 transcription factor activity, RNA polymerase I transcription factor binding(GO:0001082)
1.0 5.8 GO:0070300 phosphatidic acid binding(GO:0070300)
1.0 2.9 GO:0003825 alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity(GO:0003825)
0.9 5.7 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.9 2.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.9 5.6 GO:0003993 acid phosphatase activity(GO:0003993)
0.9 9.1 GO:0001056 RNA polymerase III activity(GO:0001056)
0.9 2.7 GO:0031370 eukaryotic initiation factor 4G binding(GO:0031370)
0.9 2.6 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.9 4.3 GO:0008526 phosphatidylcholine transporter activity(GO:0008525) phosphatidylinositol transporter activity(GO:0008526)
0.8 4.2 GO:0008143 poly(A) binding(GO:0008143) poly-purine tract binding(GO:0070717)
0.8 4.1 GO:0019201 nucleotide kinase activity(GO:0019201)
0.8 1.6 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.8 29.9 GO:0003724 RNA helicase activity(GO:0003724)
0.8 1.6 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.8 3.8 GO:0008443 phosphofructokinase activity(GO:0008443)
0.8 2.3 GO:0016433 rRNA (adenine) methyltransferase activity(GO:0016433)
0.7 7.2 GO:0031490 chromatin DNA binding(GO:0031490)
0.7 2.1 GO:0008251 adenosine deaminase activity(GO:0004000) tRNA-specific adenosine deaminase activity(GO:0008251)
0.7 7.1 GO:0000171 ribonuclease MRP activity(GO:0000171)
0.7 1.4 GO:0010521 telomerase inhibitor activity(GO:0010521)
0.7 13.1 GO:0042162 telomeric DNA binding(GO:0042162)
0.7 2.8 GO:0004338 glucan exo-1,3-beta-glucosidase activity(GO:0004338)
0.7 5.5 GO:0070001 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.7 2.1 GO:0009922 fatty acid elongase activity(GO:0009922)
0.7 2.7 GO:0004622 lysophospholipase activity(GO:0004622)
0.7 2.6 GO:0016886 ligase activity, forming phosphoric ester bonds(GO:0016886)
0.7 3.3 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.7 2.0 GO:0005519 cytoskeletal regulatory protein binding(GO:0005519)
0.6 1.9 GO:0004100 chitin synthase activity(GO:0004100)
0.6 1.9 GO:0070568 guanylyltransferase activity(GO:0070568)
0.6 3.8 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
0.6 1.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.6 1.9 GO:0043891 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891)
0.6 3.1 GO:0008536 Ran GTPase binding(GO:0008536)
0.6 2.4 GO:1904680 peptide transmembrane transporter activity(GO:1904680)
0.6 2.4 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.6 3.0 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.6 1.8 GO:0000339 RNA cap binding(GO:0000339)
0.6 1.8 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.6 5.8 GO:0003746 translation elongation factor activity(GO:0003746)
0.6 2.2 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.6 16.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.6 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.5 15.8 GO:0016876 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.5 2.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 5.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.5 2.1 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.5 1.5 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.5 1.0 GO:0072341 modified amino acid binding(GO:0072341)
0.5 5.0 GO:0005216 ion channel activity(GO:0005216)
0.5 2.0 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.5 1.4 GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
0.5 4.3 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.5 1.9 GO:0004771 sterol esterase activity(GO:0004771)
0.5 1.4 GO:0004326 tetrahydrofolylpolyglutamate synthase activity(GO:0004326)
0.5 2.3 GO:0070546 L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
0.5 1.4 GO:0019202 amino acid kinase activity(GO:0019202)
0.4 1.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.4 0.4 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.4 3.5 GO:0016866 intramolecular transferase activity(GO:0016866)
0.4 2.2 GO:0042123 glucanosyltransferase activity(GO:0042123) 1,3-beta-glucanosyltransferase activity(GO:0042124)
0.4 1.7 GO:0009378 four-way junction helicase activity(GO:0009378)
0.4 3.0 GO:0019237 centromeric DNA binding(GO:0019237)
0.4 1.7 GO:0008296 3'-5'-exodeoxyribonuclease activity(GO:0008296) single-stranded DNA exodeoxyribonuclease activity(GO:0008297) single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310)
0.4 1.3 GO:0051219 phosphoprotein binding(GO:0051219)
0.4 0.8 GO:0016778 diphosphotransferase activity(GO:0016778)
0.4 3.2 GO:0005496 steroid binding(GO:0005496) sterol binding(GO:0032934)
0.4 4.0 GO:0001133 RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding(GO:0001133)
0.4 1.2 GO:0016274 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.4 0.8 GO:0016840 carbon-nitrogen lyase activity(GO:0016840)
0.4 3.9 GO:0000049 tRNA binding(GO:0000049)
0.4 2.3 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 1.9 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
0.4 22.1 GO:0003924 GTPase activity(GO:0003924)
0.4 1.8 GO:0000146 microfilament motor activity(GO:0000146)
0.3 10.1 GO:0046982 protein heterodimerization activity(GO:0046982)
0.3 3.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.3 4.7 GO:0001671 ATPase activator activity(GO:0001671)
0.3 1.7 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.3 0.6 GO:0016838 carbon-oxygen lyase activity, acting on phosphates(GO:0016838)
0.3 6.1 GO:0005525 GTP binding(GO:0005525) guanyl nucleotide binding(GO:0019001) guanyl ribonucleotide binding(GO:0032561)
0.3 2.5 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.3 1.8 GO:0019239 deaminase activity(GO:0019239)
0.3 4.3 GO:0042803 protein homodimerization activity(GO:0042803)
0.3 1.5 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 0.9 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) thiol oxidase activity(GO:0016972)
0.3 9.7 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.3 2.6 GO:0000009 alpha-1,6-mannosyltransferase activity(GO:0000009)
0.3 0.9 GO:0070569 uridylyltransferase activity(GO:0070569)
0.3 0.9 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690) cAMP-dependent protein kinase activity(GO:0004691)
0.3 1.1 GO:0008312 7S RNA binding(GO:0008312)
0.3 0.6 GO:0043142 single-stranded DNA-dependent ATPase activity(GO:0043142)
0.3 1.1 GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
0.3 1.1 GO:0051377 mannose-ethanolamine phosphotransferase activity(GO:0051377)
0.3 0.8 GO:0019901 protein kinase binding(GO:0019901)
0.3 2.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.3 1.3 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.3 1.0 GO:0070403 NAD+ binding(GO:0070403)
0.2 1.2 GO:0016891 endoribonuclease activity, producing 5'-phosphomonoesters(GO:0016891)
0.2 0.7 GO:0008171 O-methyltransferase activity(GO:0008171)
0.2 1.2 GO:0003727 single-stranded RNA binding(GO:0003727)
0.2 1.0 GO:0001055 RNA polymerase II activity(GO:0001055)
0.2 1.0 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
0.2 6.5 GO:0015631 tubulin binding(GO:0015631)
0.2 0.9 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.2 0.9 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.2 0.2 GO:0004529 exodeoxyribonuclease activity(GO:0004529)
0.2 2.6 GO:0005199 structural constituent of cell wall(GO:0005199)
0.2 6.1 GO:0051536 iron-sulfur cluster binding(GO:0051536) metal cluster binding(GO:0051540)
0.2 0.6 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.2 1.3 GO:0030145 manganese ion binding(GO:0030145)
0.2 1.3 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)
0.2 7.2 GO:0030674 protein binding, bridging(GO:0030674)
0.2 0.8 GO:0008242 omega peptidase activity(GO:0008242)
0.2 1.6 GO:0005516 calmodulin binding(GO:0005516)
0.2 1.4 GO:0003777 microtubule motor activity(GO:0003777)
0.2 2.8 GO:0050661 NADP binding(GO:0050661)
0.2 0.8 GO:0008252 nucleotidase activity(GO:0008252)
0.2 0.4 GO:0016671 oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671)
0.2 1.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.2 0.9 GO:0008198 ferrous iron binding(GO:0008198)
0.2 0.7 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033) alcohol dehydrogenase (NADP+) activity(GO:0008106)
0.2 0.7 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 2.9 GO:0015616 DNA translocase activity(GO:0015616)
0.2 0.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.2 5.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.2 1.2 GO:0031386 protein tag(GO:0031386)
0.2 29.5 GO:0003723 RNA binding(GO:0003723)
0.2 0.6 GO:0015230 FAD transmembrane transporter activity(GO:0015230)
0.2 1.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 0.7 GO:0005338 nucleotide-sugar transmembrane transporter activity(GO:0005338)
0.1 0.6 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.4 GO:0070491 repressing transcription factor binding(GO:0070491)
0.1 3.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.1 0.4 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.1 1.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 0.3 GO:0001163 RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163)
0.1 0.4 GO:0042973 glucan endo-1,3-beta-D-glucosidase activity(GO:0042973)
0.1 0.5 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.1 2.8 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.1 0.7 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.7 GO:0070566 adenylyltransferase activity(GO:0070566)
0.1 1.7 GO:0008170 N-methyltransferase activity(GO:0008170)
0.1 3.5 GO:0043130 ubiquitin binding(GO:0043130)
0.1 0.6 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 1.2 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.1 0.2 GO:0016774 phosphotransferase activity, carboxyl group as acceptor(GO:0016774)
0.1 0.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.9 GO:0043495 protein anchor(GO:0043495)
0.1 0.8 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 0.3 GO:0034062 DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062)
0.1 5.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.3 GO:0003680 AT DNA binding(GO:0003680)
0.1 1.0 GO:0030276 clathrin binding(GO:0030276)
0.1 5.6 GO:0003682 chromatin binding(GO:0003682)
0.1 0.4 GO:0008173 RNA methyltransferase activity(GO:0008173)
0.1 4.4 GO:0008565 protein transporter activity(GO:0008565)
0.1 0.2 GO:0000403 Y-form DNA binding(GO:0000403)
0.1 0.2 GO:0001168 transcription factor activity, RNA polymerase I upstream control element sequence-specific binding(GO:0001168)
0.1 0.6 GO:0051015 actin filament binding(GO:0051015)
0.1 2.0 GO:0008092 cytoskeletal protein binding(GO:0008092)
0.1 0.6 GO:0000182 rDNA binding(GO:0000182)
0.1 0.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.1 0.1 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 0.3 GO:0019211 phosphatase activator activity(GO:0019211)
0.0 0.2 GO:0003774 motor activity(GO:0003774)
0.0 0.2 GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds(GO:0016799)
0.0 0.3 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 0.2 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.0 0.3 GO:0051087 chaperone binding(GO:0051087)
0.0 0.2 GO:0016742 hydroxymethyl-, formyl- and related transferase activity(GO:0016742)
0.0 0.2 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.0 0.1 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 0.5 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.0 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.0 GO:0008601 protein phosphatase type 2A regulator activity(GO:0008601)
0.0 0.1 GO:0000991 transcription factor activity, core RNA polymerase II binding(GO:0000991)
0.0 0.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.0 0.0 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 4.0 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.7 0.7 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.7 2.2 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.7 2.0 PID LKB1 PATHWAY LKB1 signaling events
0.6 0.6 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.6 1.7 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.6 1.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 1.8 PID E2F PATHWAY E2F transcription factor network
0.3 0.7 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.3 1.7 PID PLK1 PATHWAY PLK1 signaling events
0.3 0.6 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 1.3 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.3 2.7 PID ATR PATHWAY ATR signaling pathway
0.2 0.2 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.2 0.6 PID MYC PATHWAY C-MYC pathway
0.2 0.3 PID P73PATHWAY p73 transcription factor network
0.1 1.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.1 0.2 PID ATM PATHWAY ATM pathway
0.0 0.1 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.1 PID AURORA B PATHWAY Aurora B signaling
0.0 0.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 30.5 REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S
3.1 49.9 REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION Genes involved in 3' -UTR-mediated translational regulation
1.2 3.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
1.1 4.3 REACTOME GLYCOLYSIS Genes involved in Glycolysis
1.0 5.9 REACTOME GPCR DOWNSTREAM SIGNALING Genes involved in GPCR downstream signaling
0.9 2.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.8 1.7 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.8 3.3 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.7 1.4 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.6 4.0 REACTOME PROTEIN FOLDING Genes involved in Protein folding
0.6 2.3 REACTOME TRANSCRIPTION COUPLED NER TC NER Genes involved in Transcription-coupled NER (TC-NER)
0.6 3.9 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.6 1.7 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.5 1.6 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.5 2.1 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.4 1.3 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.4 2.4 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.4 3.9 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 0.4 REACTOME INTERFERON SIGNALING Genes involved in Interferon Signaling
0.4 1.1 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.3 1.0 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
0.3 1.5 REACTOME AXON GUIDANCE Genes involved in Axon guidance
0.2 0.6 REACTOME CLEAVAGE OF GROWING TRANSCRIPT IN THE TERMINATION REGION Genes involved in Cleavage of Growing Transcript in the Termination Region
0.2 1.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.2 0.3 REACTOME SIGNALLING TO ERKS Genes involved in Signalling to ERKs
0.1 1.4 REACTOME TRANSCRIPTION Genes involved in Transcription
0.1 0.2 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 0.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.1 0.1 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.0 0.2 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.0 0.1 REACTOME APOPTOSIS Genes involved in Apoptosis
0.0 0.1 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 0.1 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology