Results for DOT6
Z-value: 1.45
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YJR094W-A Show fit | 17.56 |
Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein |
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| YPL250W-A Show fit | 16.39 |
Identified by fungal homology and RT-PCR |
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| YNL178W Show fit | 13.91 |
Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins |
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| YDR033W Show fit | 12.88 |
Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p |
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| YFR055W Show fit | 12.70 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YPR119W Show fit | 12.50 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YGR108W Show fit | 12.34 |
B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome |
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| YGL031C Show fit | 11.63 |
Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate |
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| YFR056C Show fit | 11.30 |
Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W |
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| YBR158W Show fit | 10.75 |
Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) |
Network of associatons between targets according to the STRING database.
First level regulatory network of DOT6
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 200.5 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.0 | 65.1 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 2.6 | 46.6 | GO:0051029 | rRNA export from nucleus(GO:0006407) rRNA transport(GO:0051029) |
| 0.5 | 32.4 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.9 | 28.3 | GO:0000462 | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462) |
| 1.1 | 27.5 | GO:0000480 | endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480) |
| 3.5 | 24.8 | GO:0010696 | positive regulation of spindle pole body separation(GO:0010696) |
| 0.9 | 24.3 | GO:0033753 | ribosomal subunit export from nucleus(GO:0000054) ribosome localization(GO:0033750) establishment of ribosome localization(GO:0033753) rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428) |
| 1.7 | 23.3 | GO:0000028 | ribosomal small subunit assembly(GO:0000028) |
| 1.5 | 21.6 | GO:0042790 | transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:0042790) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 165.8 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 2.1 | 126.3 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.7 | 77.3 | GO:0005730 | nucleolus(GO:0005730) |
| 1.0 | 39.7 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.2 | 35.1 | GO:0005933 | cellular bud(GO:0005933) |
| 2.3 | 32.2 | GO:0005736 | DNA-directed RNA polymerase I complex(GO:0005736) |
| 1.0 | 24.0 | GO:0032040 | small-subunit processome(GO:0032040) |
| 0.8 | 21.6 | GO:0030686 | 90S preribosome(GO:0030686) |
| 0.3 | 12.0 | GO:0005811 | lipid particle(GO:0005811) |
| 0.7 | 11.6 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 217.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 1.2 | 49.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 2.3 | 32.2 | GO:0001054 | RNA polymerase I activity(GO:0001054) |
| 0.8 | 29.9 | GO:0003724 | RNA helicase activity(GO:0003724) |
| 0.2 | 29.5 | GO:0003723 | RNA binding(GO:0003723) |
| 1.1 | 29.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.4 | 22.1 | GO:0003924 | GTPase activity(GO:0003924) |
| 1.1 | 18.6 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.6 | 16.2 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.5 | 15.8 | GO:0016876 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 4.0 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.3 | 2.7 | PID ATR PATHWAY | ATR signaling pathway |
| 0.7 | 2.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.7 | 2.0 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 1.8 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 1.7 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.3 | 1.7 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.3 | 1.3 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 1.2 | NABA MATRISOME ASSOCIATED | Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors |
| 0.6 | 1.1 | PID ERBB4 PATHWAY | ErbB4 signaling events |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.1 | 49.9 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 3.8 | 30.5 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.0 | 5.9 | REACTOME GPCR DOWNSTREAM SIGNALING | Genes involved in GPCR downstream signaling |
| 1.1 | 4.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.6 | 4.0 | REACTOME PROTEIN FOLDING | Genes involved in Protein folding |
| 0.6 | 3.9 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.4 | 3.9 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 1.2 | 3.7 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 0.8 | 3.3 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.9 | 2.7 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |