Results for CHA4
Z-value: 1.02
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Transcription factors associated with CHA4
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CHA4
|
S000004088 | DNA binding transcriptional activator |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YOR100C Show fit | 13.28 |
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation |
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| YML042W Show fit | 10.69 |
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes |
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| YKR097W Show fit | 10.46 |
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol |
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| YIL057C Show fit | 9.18 |
Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose |
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| YLR327C Show fit | 8.22 |
Protein of unknown function that associates with ribosomes |
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| YMR017W Show fit | 6.82 |
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog |
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| YDR342C Show fit | 6.17 |
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels |
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| YNR002C Show fit | 6.12 |
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p |
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| YBR116C Show fit | 5.39 |
Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 |
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| YCL001W-B Show fit | 4.93 |
Putative protein of unknown function; identified by homology |
Network of associatons between targets according to the STRING database.
First level regulatory network of CHA4
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 15.5 | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122) |
| 4.7 | 14.0 | GO:0009437 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 1.1 | 11.5 | GO:0046487 | glyoxylate metabolic process(GO:0046487) |
| 0.4 | 10.8 | GO:0019319 | gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319) |
| 0.5 | 9.8 | GO:0015749 | hexose transport(GO:0008645) monosaccharide transport(GO:0015749) |
| 0.4 | 6.7 | GO:0009228 | thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724) |
| 0.4 | 6.6 | GO:0031321 | ascospore-type prospore assembly(GO:0031321) |
| 0.6 | 6.4 | GO:0015696 | ammonium transport(GO:0015696) |
| 0.5 | 6.3 | GO:0015986 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.1 | 6.3 | GO:0030437 | ascospore formation(GO:0030437) cell development(GO:0048468) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 25.7 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 20.3 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 0.2 | 13.0 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.8 | 9.8 | GO:0070469 | respiratory chain(GO:0070469) |
| 0.2 | 8.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.9 | 7.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.2 | 6.2 | GO:0031201 | SNARE complex(GO:0031201) |
| 1.0 | 5.2 | GO:0045273 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.4 | 4.4 | GO:0031907 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 4.0 | GO:0000324 | storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.7 | 14.0 | GO:0016406 | carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406) |
| 0.7 | 13.7 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.6 | 12.9 | GO:0015297 | antiporter activity(GO:0015297) |
| 0.1 | 12.0 | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981) |
| 0.6 | 9.1 | GO:0046906 | heme binding(GO:0020037) tetrapyrrole binding(GO:0046906) |
| 0.9 | 8.4 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.9 | 7.2 | GO:0016679 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.4 | 6.8 | GO:0008483 | transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.5 | 6.0 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 2.0 | 5.9 | GO:0015489 | putrescine transmembrane transporter activity(GO:0015489) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 81.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 3.5 | 10.5 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.9 | 2.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.4 | 2.2 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 1.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.2 | 0.6 | SA G1 AND S PHASES | Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition. |
| 0.1 | 0.4 | PID ATM PATHWAY | ATM pathway |
| 0.1 | 0.4 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.1 | 0.3 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 0.1 | 0.2 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 79.6 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 1.3 | 10.3 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 1.4 | 4.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.4 | 3.5 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.2 | 2.2 | REACTOME GLUCOSE METABOLISM | Genes involved in Glucose metabolism |
| 0.6 | 1.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.1 | 0.7 | REACTOME RNA POL II PRE TRANSCRIPTION EVENTS | Genes involved in RNA Polymerase II Pre-transcription Events |
| 0.1 | 0.6 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 0.5 | REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS | Genes involved in Homologous recombination repair of replication-independent double-strand breaks |
| 0.0 | 0.5 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |