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Results for CHA4

Z-value: 1.02

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Transcription factors associated with CHA4

Gene Symbol Gene ID Gene Info
CHA4
S000004088 DNA binding transcriptional activator

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
CHA4YLR098C0.553.8e-03Click!

Activity profile of CHA4 motif

Sorted Z-values of CHA4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
YOR100C 13.28
CRC1
Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation
YML042W 10.69
CAT2
Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes
YKR097W 10.46
PCK1
Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol
YIL057C 9.18 Putative protein of unknown function; expression induced under carbon limitation and repressed under high glucose
YLR327C 8.22
TMA10
Protein of unknown function that associates with ribosomes
YMR017W 6.82
SPO20
Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog
YDR342C 6.17
HXT7
High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels
YNR002C 6.12
ATO2
Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p
YBR116C 5.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2
YCL001W-B 4.93 Putative protein of unknown function; identified by homology
YJL133C-A 4.90 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDL210W 4.85
UGA4
Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane
YOR343C 4.74 Dubious open reading frame, unlikely to encode a functional protein; based on available experimental and comparative sequence data
YMR107W 4.65
SPG4
Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources
YMR081C 4.61
ISF1
Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant
YPL054W 4.54
LEE1
Zinc-finger protein of unknown function
YJR048W 4.31
CYC1
Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YOR348C 4.26
PUT4
Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
YPL222C-A 4.24 Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
YGR067C 4.02 Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
YFL052W 3.90 Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity
YDL244W 3.89
THI13
Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13
YLR122C 3.88 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C
YGR243W 3.80
FMP43
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YLR004C 3.75
THI73
Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs
YPR192W 3.63
AQY1
Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance
YOL084W 3.59
PHM7
Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole
YNR034W-A 3.57 Putative protein of unknown function; expression is regulated by Msn2p/Msn4p
YNL274C 3.43
GOR1
Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YER065C 3.42
ICL1
Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose
YPL171C 3.40
OYE3
Widely conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with slight differences in ligand binding and catalytic properties; may be involved in sterol metabolism
YOR374W 3.36
ALD4
Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed
YLR346C 3.27 Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene
YLR123C 3.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif
YFR053C 3.21
HXK1
Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p
YBR297W 3.18
MAL33
MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C
YDR277C 3.15
MTH1
Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation
YFL030W 3.13
AGX1
Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases
YBR105C 3.10
VID24
Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; involved in proteasome-dependent catabolite degradation of FBPase
YFL054C 3.01 Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol
YAL062W 3.00
GDH3
NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources
YEL024W 3.00
RIP1
Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration
YJL045W 2.89 Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner
YDR119W-A 2.86 Putative protein of unknown function
YGR022C 2.83 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W
YKL109W 2.81
HAP4
Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
YGR023W 2.81
MTL1
Protein with both structural and functional similarity to Mid2p, which is a plasma membrane sensor required for cell integrity signaling during pheromone-induced morphogenesis; suppresses rgd1 null mutations
YPL135W 2.77
ISU1
Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable
YHR139C 2.73
SPS100
Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall
YEL028W 2.71 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YOR065W 2.69
CYT1
Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex
YHR048W 2.63
YHK8
Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles
YAR035W 2.62
YAT1
Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
YPR191W 2.60
QCR2
Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme
YPR010C-A 2.58 Putative protein of unknown function; conserved among Saccharomyces sensu stricto species
YLR111W 2.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YLR047C 2.52
FRE8
Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p
YHR096C 2.51
HXT5
Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs
YKL065W-A 2.44 Putative protein of unknown function
YNL202W 2.43
SPS19
Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate
YDL215C 2.40
GDH2
NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels
YDR406W 2.39
PDR15
Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
YER150W 2.39
SPI1
GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p
YMR280C 2.39
CAT8
Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements
YGR146C 2.39 Putative protein of unknown function; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of a temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR149C 2.38 Putative protein of unknown function; YLR149C is not an essential gene
YDR379C-A 2.38 Hypothetical protein identified by homology. See FEBS Letters [2000] 487:31-36.
YJR155W 2.37
AAD10
Putative aryl-alcohol dehydrogenase with similarity to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role
YPR036W-A 2.32 Protein of unknown function; transcription is regulated by Pdr1p
YDL085W 2.32
NDE2
Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
YGL156W 2.31
AMS1
Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
YPR013C 2.30 Putative zinc finger protein; YPR013C is not an essential gene
YOL085W-A 2.28 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C
YOR383C 2.25
FIT3
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YDR059C 2.25
UBC5
Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins, central component of the cellular stress response; expression is heat inducible
YBR051W 2.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase
YMR056C 2.25
AAC1
Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator
YIL122W 2.21
POG1
Putative transcriptional activator that promotes recovery from pheromone induced arrest; inhibits both alpha-factor induced G1 arrest and repression of CLN1 and CLN2 via SCB/MCB promoter elements; potential Cdc28p substrate; SBF regulated
YDR259C 2.21
YAP6
Putative basic leucine zipper (bZIP) transcription factor; overexpression increases sodium and lithium tolerance
YKR034W 2.20
DAL80
Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p
YIL155C 2.19
GUT2
Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner
YER162C 2.19
RAD4
Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); homolog of human XPC protein
YLL041C 2.15
SDH2
Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YER004W 2.15
FMP52
Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation
YBR050C 2.14
REG2
Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease
YHR211W 2.10
FLO5
Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p
YLR125W 2.10 Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene
YFL051C 2.03 Putative protein of unknown function; YFL051C is not an essential gene
YNL125C 1.99
ESBP6
Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane
YPR015C 1.97 Putative protein of unknown function
YDR530C 1.97
APA2
Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p
YDR010C 1.95 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YER084W 1.92 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL201C 1.90
YIG1
Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol
YMR103C 1.90 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBR269C 1.90
FMP21
Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YDR043C 1.89
NRG1
Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response
YPL134C 1.88
ODC1
Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation
YNL144C 1.88 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YNL144C is not an essential gene
YOR186W 1.87 Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent
YKL031W 1.86 Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species
YMR306W 1.85
FKS3
Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
YIR034C 1.85
LYS1
Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway
YER014C-A 1.85
BUD25
Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern
YNL133C 1.85
FYV6
Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining
YDL245C 1.82
HXT15
Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
YNL190W 1.77 Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site
YEL070W 1.76
DSF1
Deletion suppressor of mpt5 mutation
YGL180W 1.72
ATG1
Protein serine/threonine kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for pre-autophagosome formation; during autophagy forms a complex with Atg13p and Atg17p
YPL181W 1.70
CTI6
Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain
YOR139C 1.70 Hypothetical protein
YNL074C 1.69
MLF3
Serine-rich protein of unknown function; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide
YFL053W 1.68
DAK2
Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation
YML089C 1.68 Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage
YEL011W 1.66
GLC3
Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
YAL018C 1.65 Putative protein of unknown function
YNL014W 1.65
HEF3
Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells
YMR250W 1.64
GAD1
Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress
YGL192W 1.64
IME4
Probable mRNA N6-adenosine methyltransferase that is required for IME1 transcript accumulation and for sporulation; expression is induced in starved MATa/MAT alpha diploid cells
YLR124W 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YPL182C 1.63 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W
YNL055C 1.62
POR1
Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated
YKL141W 1.60
SDH3
Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YAR053W 1.59 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
YBL043W 1.59
ECM13
Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation
YLR142W 1.58
PUT1
Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
YKL163W 1.58
PIR3
O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway
YPL092W 1.57
SSU1
Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein
YGL187C 1.57
COX4
Subunit IV of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; N-terminal 25 residues of precursor are cleaved during mitochondrial import; phosphorylated
YJL152W 1.56 Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
YGL193C 1.55 Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold
YLR366W 1.55 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A
YPL271W 1.54
ATP15
Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated
YLR312C 1.54
QNQ1
Protein of unknown function; null mutant quiescent and non-quiescent cells exhibit reduced reproductive capacity
YAL039C 1.54
CYC3
Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS)
YIL055C 1.53 Putative protein of unknown function
YCR005C 1.53
CIT2
Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors
YHR217C 1.53 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R.
YMR194C-B 1.51 Putative protein of unknown function
YDL010W 1.51
GRX6
Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX6
YCR007C 1.51 Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene
YGL045W 1.51
RIM8
Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalF
YKL016C 1.50
ATP7
Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
YIL077C 1.50 Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
YMR181C 1.50 Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene
YER103W 1.49
SSA4
Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation
YJL220W 1.48 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2
YJR096W 1.48 Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS
YLR217W 1.46 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6
YDR380W 1.46
ARO10
Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway
YKL221W 1.46
MCH2
Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
YKR067W 1.45
GPT2
Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis
YPR154W 1.45
PIN3
Protein that induces appearance of [PIN+] prion when overproduced
YDL011C 1.44 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W
YJR061W 1.44 Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p
YOR140W 1.44
SFL1
Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p
YLR438W 1.44
CAR2
L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive
YDL182W 1.41
LYS20
Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p
YER111C 1.40
SWI4
DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair
YKL026C 1.40
GPX1
Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress
YHR199C-A 1.40 Putative protein of unknown function; transcribed sequence appears to contain an intron
YBR292C 1.39 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene
YMR256C 1.39
COX7
Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
YMR105C 1.38
PGM2
Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase
YJL219W 1.37
HXT9
Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p
YKL148C 1.36
SDH1
Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone
YOL154W 1.35
ZPS1
Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH
YGR144W 1.35
THI4
Thiazole synthase, catalyzes formation of the thiazole moiety of thiamin pyrophosphate; required for thiamine biosynthesis and for mitochondrial genome stability
YEL039C 1.35
CYC7
Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration
YLR216C 1.35
CPR6
Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity
YDL138W 1.34
RGT2
Plasma membrane glucose receptor, highly similar to Snf3p; both Rgt2p and Snf3p serve as transmembrane glucose sensors generating an intracellular signal that induces expression of glucose transporter (HXT) genes
YAL054C 1.33
ACS1
Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetlyation; expressed during growth on nonfermentable carbon sources and under aerobic conditions
YDR536W 1.32
STL1
Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock
YKR009C 1.32
FOX2
Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities
YPR151C 1.30
SUE1
Mitochondrial protein required for degradation of unstable forms of cytochrome c
YNL142W 1.26
MEP2
Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation
YGR110W 1.26 Putative protein of unknown function; transcription is increased in response to genotoxic stress; plays a role in restricting Ty1 transposition
YOR382W 1.25
FIT2
Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
YHR054W-A 1.25 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2
YNL283C 1.25
WSC2
Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response
YGL096W 1.24
TOS8
Homeodomain-containing transcription factor; SBF regulated target gene that in turn regulates expression of genes involved in G1/S phase events such as bud site selection, bud emergence and cell cycle progression; similarity to Cup9p
YHR055C 1.24
CUP1-2
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YJL221C 1.23
FSP2
Protein of unknown function, expression is induced during nitrogen limitation
YHL024W 1.23
RIM4
Putative RNA-binding protein required for the expression of early and middle sporulation genes
YJL163C 1.22 Putative protein of unknown function
YCR021C 1.22
HSP30
Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase
YLR046C 1.21 Putative membrane protein, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance
YPL200W 1.21
CSM4
Protein required for accurate chromosome segregation during meiosis
YPL058C 1.21
PDR12
Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity
YLR365W 1.19 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene
YFL055W 1.19
AGP3
Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
YDR538W 1.19
PAD1
Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiX
YKR102W 1.18
FLO10
Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation
YNR050C 1.18
LYS9
Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, which is the seventh step in lysine biosynthesis pathway
YMR002W 1.18
MIC17
Mitochondrial intermembrane space cysteine motif protein; MIC17 is not an essential gene
YPL018W 1.17
CTF19
Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly
YHR097C 1.17 Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus
YHR053C 1.16
CUP1-1
Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C
YGL114W 1.15 Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters
YGR045C 1.15 Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Network of associatons between targets according to the STRING database.

First level regulatory network of CHA4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:0009437 amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437)
1.6 15.5 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
1.3 4.0 GO:0006538 glutamate catabolic process(GO:0006538)
1.2 3.7 GO:0019413 acetate biosynthetic process(GO:0019413)
1.2 4.9 GO:0015847 putrescine transport(GO:0015847)
1.2 3.5 GO:0006850 mitochondrial pyruvate transport(GO:0006850)
1.1 11.5 GO:0046487 glyoxylate metabolic process(GO:0046487)
1.1 3.3 GO:1900460 negative regulation of invasive growth in response to glucose limitation by negative regulation of transcription from RNA polymerase II promoter(GO:1900460)
1.1 5.5 GO:0006013 mannose metabolic process(GO:0006013)
1.1 4.3 GO:0015804 neutral amino acid transport(GO:0015804)
1.1 3.2 GO:0006545 glycine biosynthetic process(GO:0006545)
1.0 5.2 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
1.0 3.1 GO:0051469 vesicle fusion with vacuole(GO:0051469)
0.8 4.7 GO:0000501 flocculation(GO:0000128) flocculation via cell wall protein-carbohydrate interaction(GO:0000501)
0.8 3.9 GO:0019405 alditol catabolic process(GO:0019405) glycerol catabolic process(GO:0019563)
0.7 2.2 GO:0042128 nitrate metabolic process(GO:0042126) nitrate assimilation(GO:0042128)
0.7 2.7 GO:0006527 arginine catabolic process(GO:0006527)
0.6 2.4 GO:0046688 response to copper ion(GO:0046688)
0.6 6.4 GO:0015696 ammonium transport(GO:0015696)
0.6 1.7 GO:0019676 ammonia assimilation cycle(GO:0019676)
0.6 4.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.5 1.6 GO:0005993 trehalose catabolic process(GO:0005993)
0.5 2.2 GO:0006075 (1->3)-beta-D-glucan biosynthetic process(GO:0006075)
0.5 2.1 GO:0006083 acetate metabolic process(GO:0006083)
0.5 3.7 GO:0000023 maltose metabolic process(GO:0000023)
0.5 1.0 GO:0000821 regulation of arginine metabolic process(GO:0000821)
0.5 1.5 GO:0017003 protein-heme linkage(GO:0017003) protein-tetrapyrrole linkage(GO:0017006) cytochrome c-heme linkage(GO:0018063)
0.5 5.0 GO:0019878 lysine biosynthetic process via aminoadipic acid(GO:0019878)
0.5 9.8 GO:0015749 hexose transport(GO:0008645) monosaccharide transport(GO:0015749)
0.5 1.4 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 6.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.4 6.6 GO:0031321 ascospore-type prospore assembly(GO:0031321)
0.4 2.5 GO:0019388 galactose catabolic process(GO:0019388)
0.4 1.2 GO:0006562 proline catabolic process(GO:0006562) proline catabolic process to glutamate(GO:0010133)
0.4 1.7 GO:0009190 cAMP biosynthetic process(GO:0006171) cyclic nucleotide biosynthetic process(GO:0009190) cyclic purine nucleotide metabolic process(GO:0052652)
0.4 0.8 GO:0042816 pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819)
0.4 3.2 GO:0015891 siderophore transport(GO:0015891)
0.4 1.2 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.4 1.2 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.4 2.0 GO:0071931 positive regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0071931)
0.4 1.2 GO:0019748 secondary metabolic process(GO:0019748)
0.4 6.7 GO:0009228 thiamine biosynthetic process(GO:0009228) thiamine-containing compound biosynthetic process(GO:0042724)
0.4 1.2 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.4 1.5 GO:2000911 positive regulation of lipid transport(GO:0032370) regulation of sterol transport(GO:0032371) positive regulation of sterol transport(GO:0032373) positive regulation of transmembrane transport(GO:0034764) regulation of sterol import by regulation of transcription from RNA polymerase II promoter(GO:0035968) positive regulation of sterol import by positive regulation of transcription from RNA polymerase II promoter(GO:0035969) regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367) regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) regulation of sterol import(GO:2000909) positive regulation of sterol import(GO:2000911)
0.4 10.8 GO:0019319 gluconeogenesis(GO:0006094) hexose biosynthetic process(GO:0019319)
0.4 0.4 GO:0006848 pyruvate transport(GO:0006848)
0.4 1.4 GO:0046341 CDP-diacylglycerol biosynthetic process(GO:0016024) CDP-diacylglycerol metabolic process(GO:0046341)
0.4 1.1 GO:0070304 positive regulation of stress-activated MAPK cascade(GO:0032874) positive regulation of stress-activated protein kinase signaling cascade(GO:0070304)
0.4 1.1 GO:0009313 oligosaccharide catabolic process(GO:0009313) disaccharide catabolic process(GO:0046352)
0.3 1.7 GO:0032974 amino acid transmembrane export from vacuole(GO:0032974) vacuolar transmembrane transport(GO:0034486) vacuolar amino acid transmembrane transport(GO:0034487) amino acid transmembrane export(GO:0044746)
0.3 1.0 GO:0045950 negative regulation of mitotic recombination(GO:0045950)
0.3 2.0 GO:0009164 nucleoside catabolic process(GO:0009164) glycosyl compound catabolic process(GO:1901658)
0.3 5.8 GO:0005978 glycogen biosynthetic process(GO:0005978)
0.3 1.6 GO:0044070 regulation of anion transport(GO:0044070)
0.3 1.3 GO:0051126 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) negative regulation of actin nucleation(GO:0051126)
0.3 1.0 GO:0010994 free ubiquitin chain polymerization(GO:0010994)
0.3 1.6 GO:0008053 mitochondrial fusion(GO:0008053)
0.3 0.3 GO:0006740 NADPH regeneration(GO:0006740)
0.3 0.6 GO:0097201 negative regulation of transcription from RNA polymerase II promoter in response to stress(GO:0097201)
0.3 0.9 GO:0045596 negative regulation of cell differentiation(GO:0045596)
0.3 1.8 GO:0006768 biotin metabolic process(GO:0006768) biotin biosynthetic process(GO:0009102)
0.3 0.3 GO:0072350 tricarboxylic acid metabolic process(GO:0072350)
0.3 0.9 GO:0009450 gamma-aminobutyric acid metabolic process(GO:0009448) gamma-aminobutyric acid catabolic process(GO:0009450)
0.3 0.9 GO:0001080 nitrogen catabolite activation of transcription from RNA polymerase II promoter(GO:0001080) nitrogen catabolite activation of transcription(GO:0090294)
0.3 0.9 GO:0015888 thiamine transport(GO:0015888)
0.3 5.0 GO:0072329 monocarboxylic acid catabolic process(GO:0072329)
0.3 1.9 GO:0070086 ubiquitin-dependent endocytosis(GO:0070086)
0.3 2.9 GO:0015893 drug transport(GO:0015893)
0.3 0.3 GO:0045923 positive regulation of fatty acid biosynthetic process(GO:0045723) positive regulation of fatty acid metabolic process(GO:0045923)
0.3 0.8 GO:0006824 cobalt ion transport(GO:0006824)
0.3 0.8 GO:2000058 regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000058)
0.3 1.0 GO:0072479 cellular response to biotic stimulus(GO:0071216) response to cell cycle checkpoint signaling(GO:0072396) response to mitotic cell cycle checkpoint signaling(GO:0072414) response to spindle checkpoint signaling(GO:0072417) response to mitotic spindle checkpoint signaling(GO:0072476) response to mitotic cell cycle spindle assembly checkpoint signaling(GO:0072479) response to spindle assembly checkpoint signaling(GO:0072485) negative regulation of protein import into nucleus during spindle assembly checkpoint(GO:1901925)
0.3 1.0 GO:0032048 cardiolipin metabolic process(GO:0032048)
0.3 1.3 GO:0016239 positive regulation of macroautophagy(GO:0016239)
0.3 1.5 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.2 1.0 GO:0006285 base-excision repair, AP site formation(GO:0006285)
0.2 2.2 GO:0046686 response to cadmium ion(GO:0046686)
0.2 1.0 GO:0045141 meiotic telomere clustering(GO:0045141) establishment of chromosome localization(GO:0051303) chromosome localization to nuclear envelope involved in homologous chromosome segregation(GO:0090220)
0.2 0.9 GO:0015886 heme transport(GO:0015886)
0.2 3.9 GO:0042493 response to drug(GO:0042493)
0.2 1.3 GO:0006279 premeiotic DNA replication(GO:0006279)
0.2 0.7 GO:0015793 glycerol transport(GO:0015793)
0.2 0.7 GO:0006311 meiotic gene conversion(GO:0006311)
0.2 0.7 GO:0006119 oxidative phosphorylation(GO:0006119)
0.2 0.9 GO:0032070 regulation of deoxyribonuclease activity(GO:0032070) regulation of endodeoxyribonuclease activity(GO:0032071)
0.2 1.7 GO:0061187 regulation of chromatin silencing at rDNA(GO:0061187) negative regulation of chromatin silencing at rDNA(GO:0061188)
0.2 0.4 GO:0006827 high-affinity iron ion transmembrane transport(GO:0006827)
0.2 0.8 GO:0043901 negative regulation of conjugation(GO:0031135) negative regulation of conjugation with cellular fusion(GO:0031138) negative regulation of multi-organism process(GO:0043901)
0.2 2.8 GO:1905037 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.2 0.8 GO:0043200 response to amino acid(GO:0043200)
0.2 3.0 GO:0000436 carbon catabolite activation of transcription from RNA polymerase II promoter(GO:0000436)
0.2 1.6 GO:0000321 re-entry into mitotic cell cycle after pheromone arrest(GO:0000321)
0.2 0.4 GO:0006108 malate metabolic process(GO:0006108)
0.2 0.9 GO:0034354 'de novo' NAD biosynthetic process from tryptophan(GO:0034354) 'de novo' NAD biosynthetic process(GO:0034627)
0.2 0.5 GO:0071456 cellular response to hypoxia(GO:0071456)
0.2 3.0 GO:0042026 protein refolding(GO:0042026)
0.2 0.7 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.2 1.6 GO:0072348 sulfur compound transport(GO:0072348)
0.2 0.7 GO:0042593 cellular glucose homeostasis(GO:0001678) carbohydrate mediated signaling(GO:0009756) hexose mediated signaling(GO:0009757) sugar mediated signaling pathway(GO:0010182) glucose mediated signaling pathway(GO:0010255) carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) cellular response to monosaccharide stimulus(GO:0071326) cellular response to hexose stimulus(GO:0071331) cellular response to glucose stimulus(GO:0071333)
0.2 0.7 GO:0007039 protein catabolic process in the vacuole(GO:0007039)
0.2 0.2 GO:0034090 maintenance of meiotic sister chromatid cohesion(GO:0034090)
0.2 2.7 GO:0000209 protein polyubiquitination(GO:0000209)
0.2 0.7 GO:0051101 positive regulation of DNA binding(GO:0043388) regulation of DNA binding(GO:0051101)
0.2 0.2 GO:1901678 iron coordination entity transport(GO:1901678)
0.2 0.6 GO:0006536 glutamate metabolic process(GO:0006536)
0.2 5.0 GO:0055072 iron ion homeostasis(GO:0055072)
0.2 1.9 GO:0008608 attachment of spindle microtubules to kinetochore(GO:0008608)
0.2 0.6 GO:1903321 negative regulation of protein ubiquitination(GO:0031397) negative regulation of ligase activity(GO:0051352) negative regulation of ubiquitin-protein transferase activity(GO:0051444) negative regulation of protein modification by small protein conjugation or removal(GO:1903321)
0.2 0.6 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
0.2 0.8 GO:0001308 negative regulation of chromatin silencing involved in replicative cell aging(GO:0001308)
0.2 0.3 GO:0045117 azole transport(GO:0045117)
0.2 0.2 GO:0033683 nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.6 GO:0031507 heterochromatin assembly(GO:0031507)
0.1 1.0 GO:0031440 regulation of mRNA 3'-end processing(GO:0031440)
0.1 0.4 GO:0036257 multivesicular body organization(GO:0036257)
0.1 1.1 GO:0045332 phospholipid translocation(GO:0045332)
0.1 0.3 GO:0001178 regulation of transcriptional start site selection at RNA polymerase II promoter(GO:0001178)
0.1 0.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
0.1 0.4 GO:0010466 negative regulation of peptidase activity(GO:0010466) regulation of peptidase activity(GO:0052547)
0.1 5.4 GO:0009060 aerobic respiration(GO:0009060)
0.1 0.4 GO:0006501 C-terminal protein lipidation(GO:0006501)
0.1 0.7 GO:0046461 triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464)
0.1 5.0 GO:0006631 fatty acid metabolic process(GO:0006631)
0.1 0.3 GO:0042843 D-xylose catabolic process(GO:0042843)
0.1 0.4 GO:0018195 peptidyl-arginine modification(GO:0018195) peptidyl-arginine methylation(GO:0018216)
0.1 1.6 GO:0006749 glutathione metabolic process(GO:0006749)
0.1 0.5 GO:0036498 mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response(GO:0030969) IRE1-mediated unfolded protein response(GO:0036498) mRNA splicing, via endonucleolytic cleavage and ligation(GO:0070054)
0.1 0.3 GO:0035459 cargo loading into vesicle(GO:0035459) cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.1 GO:0044818 mitotic G2/M transition checkpoint(GO:0044818)
0.1 0.4 GO:0016241 regulation of macroautophagy(GO:0016241)
0.1 1.0 GO:0031070 intronic snoRNA processing(GO:0031070) intronic box C/D snoRNA processing(GO:0034965)
0.1 0.6 GO:0006829 zinc II ion transport(GO:0006829)
0.1 0.4 GO:0005991 trehalose metabolic process(GO:0005991)
0.1 0.5 GO:0051654 establishment of mitochondrion localization(GO:0051654)
0.1 0.9 GO:0032889 regulation of vacuole fusion, non-autophagic(GO:0032889) regulation of vacuole organization(GO:0044088)
0.1 0.4 GO:0008214 protein demethylation(GO:0006482) protein dealkylation(GO:0008214) histone demethylation(GO:0016577) demethylation(GO:0070988)
0.1 0.5 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 2.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.1 0.1 GO:0072337 modified amino acid transport(GO:0072337)
0.1 0.6 GO:0060963 positive regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0060963)
0.1 6.3 GO:0030437 ascospore formation(GO:0030437) cell development(GO:0048468)
0.1 0.7 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.1 0.9 GO:0033617 mitochondrial respiratory chain complex IV assembly(GO:0033617)
0.1 0.2 GO:2000756 regulation of histone modification(GO:0031056) regulation of histone acetylation(GO:0035065) regulation of protein acetylation(GO:1901983) regulation of peptidyl-lysine acetylation(GO:2000756)
0.1 0.4 GO:0000709 meiotic joint molecule formation(GO:0000709)
0.1 0.8 GO:0015802 basic amino acid transport(GO:0015802)
0.1 0.3 GO:0009065 glutamine family amino acid catabolic process(GO:0009065)
0.1 0.6 GO:0097034 mitochondrial respiratory chain complex IV biogenesis(GO:0097034)
0.1 0.3 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.1 0.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 0.3 GO:0000707 meiotic DNA recombinase assembly(GO:0000707) DNA recombinase assembly(GO:0000730)
0.1 0.6 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 0.2 GO:0042407 cristae formation(GO:0042407)
0.1 0.2 GO:0045991 carbon catabolite activation of transcription(GO:0045991)
0.1 0.4 GO:0070096 mitochondrial outer membrane translocase complex assembly(GO:0070096)
0.1 0.3 GO:0006598 polyamine catabolic process(GO:0006598)
0.1 0.4 GO:0046931 pore complex assembly(GO:0046931) nuclear pore complex assembly(GO:0051292)
0.1 0.3 GO:0046685 response to arsenic-containing substance(GO:0046685)
0.1 0.1 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.1 0.5 GO:0070272 proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.2 GO:0016579 protein deubiquitination(GO:0016579)
0.1 0.2 GO:0000117 regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0000117) positive regulation of transcription involved in G2/M transition of mitotic cell cycle(GO:0090282)
0.1 0.1 GO:1900182 mitotic spindle disassembly(GO:0051228) spindle disassembly(GO:0051230) cytoplasm-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071629) positive regulation of protein localization to nucleus(GO:1900182) positive regulation of cellular protein localization(GO:1903829)
0.1 0.2 GO:0001113 transcriptional open complex formation at RNA polymerase II promoter(GO:0001113)
0.1 0.1 GO:0042173 regulation of sporulation resulting in formation of a cellular spore(GO:0042173)
0.1 0.2 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.1 0.1 GO:0006012 galactose metabolic process(GO:0006012)
0.1 0.1 GO:0010688 negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter(GO:0010688)
0.1 0.8 GO:0006312 mitotic recombination(GO:0006312)
0.1 0.1 GO:0042732 D-xylose metabolic process(GO:0042732)
0.1 0.7 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.1 0.1 GO:0044154 histone H3 acetylation(GO:0043966) histone H3-K9 acetylation(GO:0043970) histone H3-K14 acetylation(GO:0044154) histone H3-K9 modification(GO:0061647)
0.0 0.4 GO:0051220 cytoplasmic sequestering of protein(GO:0051220)
0.0 0.2 GO:0006551 leucine metabolic process(GO:0006551) leucine biosynthetic process(GO:0009098)
0.0 0.3 GO:0000338 protein deneddylation(GO:0000338) cullin deneddylation(GO:0010388)
0.0 0.1 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.2 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808)
0.0 0.2 GO:0055075 cellular potassium ion homeostasis(GO:0030007) potassium ion homeostasis(GO:0055075)
0.0 0.3 GO:0000491 small nucleolar ribonucleoprotein complex assembly(GO:0000491)
0.0 0.3 GO:0000902 cell morphogenesis(GO:0000902)
0.0 0.5 GO:0001101 response to acid chemical(GO:0001101)
0.0 0.4 GO:0000422 mitophagy(GO:0000422) mitochondrion disassembly(GO:0061726)
0.0 0.2 GO:0019722 calcium-mediated signaling(GO:0019722)
0.0 0.3 GO:0010821 regulation of mitochondrion organization(GO:0010821)
0.0 1.9 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.6 GO:0001300 chronological cell aging(GO:0001300)
0.0 0.3 GO:0000753 cell morphogenesis involved in conjugation with cellular fusion(GO:0000753)
0.0 1.8 GO:0006289 nucleotide-excision repair(GO:0006289)
0.0 0.5 GO:0007121 bipolar cellular bud site selection(GO:0007121)
0.0 0.2 GO:0000755 cytogamy(GO:0000755)
0.0 0.4 GO:0051293 establishment of spindle localization(GO:0051293) spindle localization(GO:0051653)
0.0 0.1 GO:0070932 histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933)
0.0 0.2 GO:0015858 nucleoside transport(GO:0015858)
0.0 0.1 GO:0046578 regulation of Ras protein signal transduction(GO:0046578)
0.0 0.4 GO:0018208 protein peptidyl-prolyl isomerization(GO:0000413) peptidyl-proline modification(GO:0018208)
0.0 0.2 GO:0005977 glycogen metabolic process(GO:0005977) energy reserve metabolic process(GO:0006112)
0.0 0.2 GO:0006591 ornithine metabolic process(GO:0006591)
0.0 0.3 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 0.1 GO:0031297 replication fork processing(GO:0031297)
0.0 0.2 GO:0006490 oligosaccharide-lipid intermediate biosynthetic process(GO:0006490)
0.0 0.1 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.1 GO:0071241 response to iron ion(GO:0010039) regulation of transcription from RNA polymerase II promoter in response to iron(GO:0034395) cellular response to inorganic substance(GO:0071241) cellular response to metal ion(GO:0071248) cellular response to iron ion(GO:0071281)
0.0 0.0 GO:0090630 activation of GTPase activity(GO:0090630)
0.0 0.2 GO:0022900 electron transport chain(GO:0022900)
0.0 0.1 GO:0070828 heterochromatin organization(GO:0070828)
0.0 0.2 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.1 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.0 0.1 GO:0051601 exocyst assembly(GO:0001927) exocyst localization(GO:0051601)
0.0 0.1 GO:0060237 regulation of fungal-type cell wall organization(GO:0060237)
0.0 0.4 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 0.2 GO:0043486 histone exchange(GO:0043486)
0.0 0.0 GO:0031055 chromatin remodeling at centromere(GO:0031055)
0.0 0.5 GO:0016573 histone acetylation(GO:0016573)
0.0 0.1 GO:2000001 regulation of cell cycle checkpoint(GO:1901976) negative regulation of cell cycle checkpoint(GO:1901977) regulation of DNA damage checkpoint(GO:2000001) negative regulation of DNA damage checkpoint(GO:2000002) negative regulation of response to DNA damage stimulus(GO:2001021)
0.0 0.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0030149 sphingolipid catabolic process(GO:0030149) membrane lipid catabolic process(GO:0046466)
0.0 0.1 GO:0016233 telomere capping(GO:0016233)
0.0 0.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.1 GO:0006077 (1->6)-beta-D-glucan metabolic process(GO:0006077)
0.0 0.3 GO:0007117 budding cell bud growth(GO:0007117)
0.0 0.2 GO:0046854 lipid phosphorylation(GO:0046834) phosphatidylinositol phosphorylation(GO:0046854)
0.0 0.0 GO:0006883 cellular sodium ion homeostasis(GO:0006883) sodium ion homeostasis(GO:0055078)
0.0 0.1 GO:0033108 mitochondrial respiratory chain complex assembly(GO:0033108)
0.0 0.0 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.2 GO:0006298 mismatch repair(GO:0006298)
0.0 0.0 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.0 0.1 GO:0001009 transcription from RNA polymerase III type 2 promoter(GO:0001009) transcription from a RNA polymerase III hybrid type promoter(GO:0001041)
0.0 0.0 GO:0043419 urea catabolic process(GO:0043419)
0.0 0.0 GO:0097035 lipid translocation(GO:0034204) regulation of membrane lipid distribution(GO:0097035)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.8 GO:0030061 mitochondrial crista(GO:0030061)
1.0 5.2 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.9 7.2 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.8 2.4 GO:0045269 mitochondrial proton-transporting ATP synthase, central stalk(GO:0005756) proton-transporting ATP synthase, central stalk(GO:0045269)
0.8 9.8 GO:0070469 respiratory chain(GO:0070469)
0.7 2.8 GO:0016602 CCAAT-binding factor complex(GO:0016602)
0.7 2.0 GO:0000111 nucleotide-excision repair factor 2 complex(GO:0000111)
0.6 1.7 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.5 2.2 GO:0000148 1,3-beta-D-glucan synthase complex(GO:0000148)
0.5 1.6 GO:0046930 pore complex(GO:0046930)
0.5 3.7 GO:0034657 GID complex(GO:0034657)
0.5 1.5 GO:0005796 Golgi lumen(GO:0005796)
0.5 1.5 GO:0000274 mitochondrial proton-transporting ATP synthase, stator stalk(GO:0000274) proton-transporting ATP synthase, stator stalk(GO:0045265)
0.5 3.9 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.5 1.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 0.9 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 4.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.3 1.4 GO:0033309 SBF transcription complex(GO:0033309)
0.3 0.7 GO:0032126 eisosome(GO:0032126)
0.3 0.9 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.3 1.2 GO:0000817 COMA complex(GO:0000817)
0.3 0.8 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 1.6 GO:0032777 Piccolo NuA4 histone acetyltransferase complex(GO:0032777)
0.2 6.2 GO:0031201 SNARE complex(GO:0031201)
0.2 1.5 GO:0045263 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.2 0.7 GO:0097042 extrinsic component of fungal-type vacuolar membrane(GO:0097042)
0.2 13.0 GO:0042579 peroxisome(GO:0005777) microbody(GO:0042579)
0.2 1.5 GO:0042597 periplasmic space(GO:0042597)
0.2 8.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.2 0.7 GO:0016587 Isw1 complex(GO:0016587)
0.2 1.1 GO:0034967 Set3 complex(GO:0034967)
0.2 0.5 GO:0051286 cell tip(GO:0051286)
0.2 1.7 GO:0030677 ribonuclease P complex(GO:0030677)
0.2 0.6 GO:0072380 ER membrane insertion complex(GO:0072379) TRC complex(GO:0072380)
0.2 0.6 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) nucleoplasmic THO complex(GO:0000446)
0.2 0.5 GO:0045240 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) mitochondrial oxoglutarate dehydrogenase complex(GO:0009353) dihydrolipoyl dehydrogenase complex(GO:0045240) oxoglutarate dehydrogenase complex(GO:0045252)
0.1 1.9 GO:0031306 intrinsic component of mitochondrial outer membrane(GO:0031306) integral component of mitochondrial outer membrane(GO:0031307)
0.1 0.3 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.1 0.4 GO:0032585 multivesicular body membrane(GO:0032585)
0.1 20.3 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 0.3 GO:0030874 nucleolar chromatin(GO:0030874)
0.1 0.4 GO:0030870 Mre11 complex(GO:0030870)
0.1 0.3 GO:0031422 RecQ helicase-Topo III complex(GO:0031422)
0.1 0.4 GO:0005946 alpha,alpha-trehalose-phosphate synthase complex (UDP-forming)(GO:0005946)
0.1 0.3 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.1 0.5 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.1 0.5 GO:0033100 NuA3 histone acetyltransferase complex(GO:0033100) H3 histone acetyltransferase complex(GO:0070775)
0.1 0.9 GO:0000328 fungal-type vacuole lumen(GO:0000328)
0.1 0.3 GO:0032389 MutLalpha complex(GO:0032389)
0.1 0.7 GO:0000112 nucleotide-excision repair factor 3 complex(GO:0000112)
0.1 1.3 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.5 GO:0033101 cellular bud membrane(GO:0033101)
0.1 1.3 GO:0098552 side of membrane(GO:0098552) cytoplasmic side of membrane(GO:0098562)
0.1 1.1 GO:0033698 Rpd3L complex(GO:0033698)
0.1 0.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 0.2 GO:0043291 RAVE complex(GO:0043291)
0.1 1.1 GO:0005811 lipid particle(GO:0005811)
0.1 0.2 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.1 0.3 GO:0032432 actin filament bundle(GO:0032432)
0.0 0.3 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.0 0.3 GO:0008180 COP9 signalosome(GO:0008180)
0.0 0.1 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.7 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 0.2 GO:0000444 MIS12/MIND type complex(GO:0000444) nuclear MIS12/MIND complex(GO:0000818)
0.0 0.4 GO:0098797 plasma membrane protein complex(GO:0098797)
0.0 3.8 GO:0009277 fungal-type cell wall(GO:0009277)
0.0 0.4 GO:0030915 Smc5-Smc6 complex(GO:0030915)
0.0 0.2 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.0 1.0 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 0.7 GO:0000152 nuclear ubiquitin ligase complex(GO:0000152)
0.0 0.3 GO:0012510 trans-Golgi network transport vesicle membrane(GO:0012510)
0.0 25.7 GO:0005739 mitochondrion(GO:0005739)
0.0 0.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.7 GO:0016592 mediator complex(GO:0016592)
0.0 0.8 GO:0005770 late endosome(GO:0005770)
0.0 0.1 GO:0070772 PAS complex(GO:0070772)
0.0 0.2 GO:0016272 prefoldin complex(GO:0016272)
0.0 0.7 GO:0005643 nuclear pore(GO:0005643)
0.0 4.0 GO:0000324 storage vacuole(GO:0000322) lytic vacuole(GO:0000323) fungal-type vacuole(GO:0000324)
0.0 0.1 GO:0031262 Ndc80 complex(GO:0031262)
0.0 0.5 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 0.1 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.0 0.1 GO:0035361 Cul8-RING ubiquitin ligase complex(GO:0035361)
0.0 0.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.0 0.0 GO:0005618 cell wall(GO:0005618) external encapsulating structure(GO:0030312)
0.0 0.2 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006) catalytic step 1 spliceosome(GO:0071012)
0.0 0.1 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.0 0.1 GO:0000782 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.0 0.1 GO:0005869 dynactin complex(GO:0005869)
0.0 0.0 GO:0031205 endoplasmic reticulum Sec complex(GO:0031205) Sec62/Sec63 complex(GO:0031207)
0.0 0.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 0.1 GO:0005802 trans-Golgi network(GO:0005802)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 14.0 GO:0016406 carnitine O-acetyltransferase activity(GO:0004092) carnitine O-acyltransferase activity(GO:0016406)
2.0 5.9 GO:0015489 putrescine transmembrane transporter activity(GO:0015489)
1.2 4.7 GO:0005537 mannose binding(GO:0005537)
1.2 3.5 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
1.0 5.2 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
1.0 4.1 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.9 8.4 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.9 7.2 GO:0016679 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.9 2.6 GO:0050136 NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.9 3.5 GO:0004396 hexokinase activity(GO:0004396)
0.8 4.1 GO:0008198 ferrous iron binding(GO:0008198)
0.7 2.2 GO:0036440 citrate (Si)-synthase activity(GO:0004108) citrate synthase activity(GO:0036440)
0.7 2.2 GO:0003843 1,3-beta-D-glucan synthase activity(GO:0003843)
0.7 2.8 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.7 4.1 GO:0016833 oxo-acid-lyase activity(GO:0016833)
0.7 13.7 GO:0016831 carboxy-lyase activity(GO:0016831)
0.7 4.0 GO:0004029 aldehyde dehydrogenase (NAD) activity(GO:0004029) aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030)
0.6 12.9 GO:0015297 antiporter activity(GO:0015297)
0.6 2.9 GO:0004559 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.6 2.3 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.6 9.1 GO:0046906 heme binding(GO:0020037) tetrapyrrole binding(GO:0046906)
0.6 2.2 GO:0016405 CoA-ligase activity(GO:0016405) acid-thiol ligase activity(GO:0016878)
0.5 6.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.5 1.6 GO:0004555 alpha,alpha-trehalase activity(GO:0004555) trehalase activity(GO:0015927)
0.5 2.2 GO:0015146 pentose transmembrane transporter activity(GO:0015146)
0.5 1.6 GO:0005253 anion channel activity(GO:0005253) voltage-gated anion channel activity(GO:0008308) porin activity(GO:0015288) wide pore channel activity(GO:0022829)
0.5 4.7 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.5 2.4 GO:0005354 galactose transmembrane transporter activity(GO:0005354)
0.4 1.3 GO:0005536 glucose binding(GO:0005536)
0.4 4.0 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 3.8 GO:0022838 substrate-specific channel activity(GO:0022838)
0.4 2.5 GO:0005310 dicarboxylic acid transmembrane transporter activity(GO:0005310)
0.4 2.0 GO:0018456 aryl-alcohol dehydrogenase (NAD+) activity(GO:0018456)
0.4 2.4 GO:0015037 peptide disulfide oxidoreductase activity(GO:0015037) glutathione disulfide oxidoreductase activity(GO:0015038)
0.4 2.4 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 6.8 GO:0008483 transaminase activity(GO:0008483) transferase activity, transferring nitrogenous groups(GO:0016769)
0.3 3.0 GO:0000293 ferric-chelate reductase activity(GO:0000293) oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor(GO:0016723)
0.3 4.6 GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors(GO:0016645)
0.3 1.3 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.3 0.9 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.3 0.9 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.3 0.9 GO:0032183 SUMO binding(GO:0032183)
0.3 2.0 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
0.3 1.4 GO:0045118 azole transporter activity(GO:0045118)
0.3 1.4 GO:0004364 glutathione transferase activity(GO:0004364)
0.3 1.7 GO:0090599 alpha-glucosidase activity(GO:0090599)
0.3 0.3 GO:0072341 modified amino acid binding(GO:0072341)
0.3 0.8 GO:0047066 phospholipid-hydroperoxide glutathione peroxidase activity(GO:0047066)
0.3 0.8 GO:0004805 trehalose-phosphatase activity(GO:0004805)
0.3 1.3 GO:0016668 oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor(GO:0016668)
0.2 0.7 GO:0015295 solute:proton symporter activity(GO:0015295)
0.2 5.8 GO:0005484 SNAP receptor activity(GO:0005484)
0.2 2.6 GO:0035064 methylated histone binding(GO:0035064)
0.2 0.7 GO:0016289 CoA hydrolase activity(GO:0016289)
0.2 0.7 GO:0008972 hydroxymethylpyrimidine kinase activity(GO:0008902) phosphomethylpyrimidine kinase activity(GO:0008972)
0.2 1.1 GO:0004806 triglyceride lipase activity(GO:0004806) retinyl-palmitate esterase activity(GO:0050253)
0.2 0.6 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.2 0.6 GO:0016882 cyclo-ligase activity(GO:0016882)
0.2 0.4 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.2 0.6 GO:0015658 L-tyrosine transmembrane transporter activity(GO:0005302) L-glutamine transmembrane transporter activity(GO:0015186) L-isoleucine transmembrane transporter activity(GO:0015188) branched-chain amino acid transmembrane transporter activity(GO:0015658)
0.2 1.8 GO:1901682 sulfur compound transmembrane transporter activity(GO:1901682)
0.2 1.0 GO:0019104 DNA N-glycosylase activity(GO:0019104)
0.2 0.6 GO:0003840 gamma-glutamyltransferase activity(GO:0003840)
0.2 0.6 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.2 0.8 GO:0016531 copper chaperone activity(GO:0016531)
0.2 2.5 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
0.2 1.1 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.2 2.8 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.2 0.5 GO:0070569 uridylyltransferase activity(GO:0070569)
0.2 1.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.2 1.7 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 0.8 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.8 GO:0004707 MAP kinase activity(GO:0004707)
0.2 1.8 GO:0099600 receptor activity(GO:0004872) transmembrane signaling receptor activity(GO:0004888) signaling receptor activity(GO:0038023) molecular transducer activity(GO:0060089) transmembrane receptor activity(GO:0099600)
0.2 0.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.2 0.5 GO:0051183 vitamin transporter activity(GO:0051183)
0.1 3.4 GO:0004402 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.1 1.1 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.1 1.1 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.1 1.3 GO:0016413 O-acetyltransferase activity(GO:0016413)
0.1 0.7 GO:0097372 NAD-dependent histone deacetylase activity (H3-K18 specific)(GO:0097372)
0.1 0.4 GO:0004866 endopeptidase inhibitor activity(GO:0004866) peptidase inhibitor activity(GO:0030414)
0.1 1.0 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
0.1 2.0 GO:0016859 peptidyl-prolyl cis-trans isomerase activity(GO:0003755) cis-trans isomerase activity(GO:0016859)
0.1 3.0 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.1 0.4 GO:0003691 double-stranded telomeric DNA binding(GO:0003691)
0.1 0.4 GO:0016273 arginine N-methyltransferase activity(GO:0016273) protein-arginine N-methyltransferase activity(GO:0016274)
0.1 0.4 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.8 GO:0015174 basic amino acid transmembrane transporter activity(GO:0015174)
0.1 0.9 GO:0000149 SNARE binding(GO:0000149)
0.1 0.7 GO:0005102 receptor binding(GO:0005102)
0.1 0.6 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen(GO:0016701) oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 0.6 GO:0016597 amino acid binding(GO:0016597)
0.1 1.1 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 1.0 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.1 0.6 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 0.4 GO:0030246 carbohydrate binding(GO:0030246)
0.1 12.0 GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding(GO:0000981)
0.1 0.3 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.1 0.5 GO:0019203 carbohydrate phosphatase activity(GO:0019203) sugar-phosphatase activity(GO:0050308)
0.1 1.2 GO:0008599 protein phosphatase type 1 regulator activity(GO:0008599)
0.1 0.5 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.1 0.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 0.6 GO:0016653 oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor(GO:0016653)
0.1 0.2 GO:0019902 phosphatase binding(GO:0019902) protein phosphatase binding(GO:0019903)
0.1 0.3 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 0.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 0.3 GO:0004619 phosphoglycerate mutase activity(GO:0004619)
0.1 0.4 GO:0016782 transferase activity, transferring sulfur-containing groups(GO:0016782)
0.1 1.0 GO:0050661 NADP binding(GO:0050661)
0.1 0.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 0.2 GO:0015203 polyamine transmembrane transporter activity(GO:0015203)
0.1 0.3 GO:0019776 Atg8 ligase activity(GO:0019776)
0.1 0.2 GO:0016408 C-acyltransferase activity(GO:0016408)
0.1 0.6 GO:0051119 sugar transmembrane transporter activity(GO:0051119)
0.1 0.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.1 0.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847)
0.1 0.6 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 0.4 GO:0001139 transcription factor activity, core RNA polymerase II recruiting(GO:0001139)
0.1 0.3 GO:0002161 aminoacyl-tRNA editing activity(GO:0002161)
0.1 0.6 GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620)
0.1 0.3 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
0.1 0.1 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136) NAD-dependent protein deacetylase activity(GO:0034979)
0.1 0.2 GO:0000268 peroxisome targeting sequence binding(GO:0000268)
0.1 0.4 GO:0008379 thioredoxin peroxidase activity(GO:0008379) peroxiredoxin activity(GO:0051920)
0.1 0.3 GO:0000400 four-way junction DNA binding(GO:0000400)
0.1 0.3 GO:0030983 mismatched DNA binding(GO:0030983)
0.1 0.3 GO:0015205 nucleobase transmembrane transporter activity(GO:0015205)
0.0 1.2 GO:0003684 damaged DNA binding(GO:0003684)
0.0 0.1 GO:0001129 RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly(GO:0001129)
0.0 0.6 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.8 GO:0008081 phosphoric diester hydrolase activity(GO:0008081)
0.0 0.2 GO:0016885 ligase activity, forming carbon-carbon bonds(GO:0016885)
0.0 0.9 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.2 GO:0043141 5'-3' DNA helicase activity(GO:0043139) ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
0.0 0.2 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.0 0.4 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.5 GO:0045182 translation regulator activity(GO:0045182)
0.0 0.1 GO:0004457 lactate dehydrogenase activity(GO:0004457) D-lactate dehydrogenase (cytochrome) activity(GO:0004458) oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor(GO:0016898)
0.0 0.1 GO:0004584 dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity(GO:0004584)
0.0 0.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.0 2.3 GO:0051082 unfolded protein binding(GO:0051082)
0.0 0.1 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0 0.1 GO:0008235 metalloexopeptidase activity(GO:0008235)
0.0 0.3 GO:0016298 lipase activity(GO:0016298)
0.0 0.2 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 0.5 GO:0003678 DNA helicase activity(GO:0003678)
0.0 0.4 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.0 0.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 0.1 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.0 0.3 GO:0004221 obsolete ubiquitin thiolesterase activity(GO:0004221)
0.0 0.2 GO:0000384 first spliceosomal transesterification activity(GO:0000384)
0.0 0.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 0.0 GO:0004738 pyruvate dehydrogenase activity(GO:0004738)
0.0 1.2 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.0 0.1 GO:0008171 O-methyltransferase activity(GO:0008171)
0.0 0.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389)
0.0 0.1 GO:0001008 RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003) transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting(GO:0001004) transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting(GO:0001005) transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting(GO:0001008) RNA polymerase III type 2 promoter DNA binding(GO:0001031) RNA polymerase III transcription factor activity, sequence-specific DNA binding(GO:0001034)
0.0 0.1 GO:0001671 ATPase activator activity(GO:0001671)
0.0 0.0 GO:0004075 biotin carboxylase activity(GO:0004075)
0.0 0.3 GO:0008237 metallopeptidase activity(GO:0008237)
0.0 0.1 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 10.5 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 2.7 PID IL4 2PATHWAY IL4-mediated signaling events
0.6 1.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 2.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 0.6 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.1 0.4 PID ATM PATHWAY ATM pathway
0.1 0.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.1 0.2 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 0.2 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 81.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 0.3 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.1 PID P73PATHWAY p73 transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
1.3 10.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.6 1.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 3.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.2 2.2 REACTOME GLUCOSE METABOLISM Genes involved in Glucose metabolism
0.2 0.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.1 0.6 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.7 REACTOME RNA POL II PRE TRANSCRIPTION EVENTS Genes involved in RNA Polymerase II Pre-transcription Events
0.1 0.2 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.1 79.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.2 REACTOME TRANSMEMBRANE TRANSPORT OF SMALL MOLECULES Genes involved in Transmembrane transport of small molecules
0.0 0.5 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.0 0.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.0 0.1 REACTOME DEVELOPMENTAL BIOLOGY Genes involved in Developmental Biology
0.0 0.1 REACTOME CLASS A1 RHODOPSIN LIKE RECEPTORS Genes involved in Class A/1 (Rhodopsin-like receptors)