Results for CBF1
Z-value: 1.17
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Transcription factors associated with CBF1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
|
CBF1
|
S000003821 | Dual function helix-loop-helix protein |
Activity-expression correlation:
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| YDR509W Show fit | 17.39 |
Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data |
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| YDR508C Show fit | 17.07 |
High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids |
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| YPL250W-A Show fit | 13.52 |
Identified by fungal homology and RT-PCR |
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| YHR136C Show fit | 12.96 |
Protein with similarity to cyclin-dependent kinase inhibitors, overproduction suppresses a plc1 null mutation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern |
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| YDR502C Show fit | 9.71 |
S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) |
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| YER124C Show fit | 9.14 |
Daughter cell-specific protein, may participate in pathways regulating cell wall metabolism; deletion affects cell separation after division and sensitivity to drugs targeted against the cell wall |
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| YJR009C Show fit | 8.58 |
Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell-wall |
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| YDR497C Show fit | 8.54 |
Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p |
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| YFR055W Show fit | 7.75 |
Putative cystathionine beta-lyase; involved in copper ion homeostasis and sulfur metabolism; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner |
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| YHR137W Show fit | 7.62 |
Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism |
Network of associatons between targets according to the STRING database.
First level regulatory network of CBF1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 25.1 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 1.8 | 18.1 | GO:0006797 | polyphosphate metabolic process(GO:0006797) |
| 0.1 | 14.3 | GO:0006364 | rRNA processing(GO:0006364) |
| 0.8 | 12.0 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 2.4 | 9.7 | GO:0046500 | S-adenosylmethionine metabolic process(GO:0046500) |
| 1.3 | 9.0 | GO:0060238 | regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion(GO:0010969) regulation of signal transduction involved in conjugation with cellular fusion(GO:0060238) |
| 2.8 | 8.5 | GO:0097052 | L-kynurenine metabolic process(GO:0097052) L-kynurenine catabolic process(GO:0097053) |
| 1.3 | 7.9 | GO:0006491 | N-glycan processing(GO:0006491) |
| 1.9 | 7.8 | GO:0009423 | chorismate biosynthetic process(GO:0009423) |
| 2.6 | 7.7 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 25.7 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.1 | 20.8 | GO:0005933 | cellular bud(GO:0005933) |
| 0.1 | 19.0 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 0.1 | 11.0 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.3 | 10.8 | GO:0005811 | lipid particle(GO:0005811) |
| 0.2 | 9.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 8.8 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 8.1 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
| 0.0 | 8.0 | GO:0005886 | plasma membrane(GO:0005886) |
| 0.6 | 7.1 | GO:0030688 | preribosome, small subunit precursor(GO:0030688) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 17.4 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 4.2 | 16.8 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 1.1 | 12.1 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 1.5 | 9.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 1.7 | 8.7 | GO:0080130 | L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130) |
| 2.8 | 8.5 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.2 | 7.7 | GO:0019843 | rRNA binding(GO:0019843) |
| 2.4 | 7.1 | GO:0004365 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.6 | 6.9 | GO:0005199 | structural constituent of cell wall(GO:0005199) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 4.2 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.5 | 1.9 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.9 | 1.7 | SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES | Genes related to the insulin receptor pathway |
| 0.5 | 1.0 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 0.5 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 0.5 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.2 | 0.3 | PID RET PATHWAY | Signaling events regulated by Ret tyrosine kinase |
| 0.0 | 0.1 | PID AVB3 INTEGRIN PATHWAY | Integrins in angiogenesis |
| 0.0 | 0.1 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.0 | 0.1 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 5.0 | REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX | Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex |
| 0.7 | 4.6 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 1.0 | 4.0 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.8 | 3.2 | REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS | Genes involved in Glycerophospholipid biosynthesis |
| 0.3 | 2.6 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.6 | 1.9 | REACTOME SHC1 EVENTS IN ERBB4 SIGNALING | Genes involved in SHC1 events in ERBB4 signaling |
| 0.6 | 1.7 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.2 | 0.7 | REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS | Genes involved in Synthesis of substrates in N-glycan biosythesis |
| 0.1 | 0.5 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.1 | 0.5 | REACTOME UNWINDING OF DNA | Genes involved in Unwinding of DNA |