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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zkscan3

Z-value: 0.90

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Transcription factors associated with Zkscan3

Gene Symbol Gene ID Gene Info
Zkscan3
ENSRNOG00000055000 zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zkscan3rn6_v1_chr17_+_45247776_45247794-0.311.2e-08Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_48365784 58.14 ENSRNOT00000077317
Dao
D-amino-acid oxidase
chr1_-_221917901 45.94 ENSRNOT00000092270
Slc22a12
solute carrier family 22 member 12
chr3_-_94686989 44.74 ENSRNOT00000016677
Depdc7
DEP domain containing 7
chr10_-_62254287 33.44 ENSRNOT00000004313
Serpinf1
serpin family F member 1
chr9_-_82461903 29.99 ENSRNOT00000026654
Ptprn
protein tyrosine phosphatase, receptor type, N
chr9_+_49479023 29.08 ENSRNOT00000050922
ENSRNOT00000077111
Pou3f3
POU class 3 homeobox 3
chr4_-_148845267 28.41 ENSRNOT00000037397
Tmem72
transmembrane protein 72
chr15_-_45550285 27.06 ENSRNOT00000012948
Gucy1b2
guanylate cyclase 1 soluble subunit beta 2
chr9_-_71852113 25.28 ENSRNOT00000083263
ENSRNOT00000072983
AABR07067896.1

chr12_+_47698947 22.23 ENSRNOT00000001586
Trpv4
transient receptor potential cation channel, subfamily V, member 4
chr10_+_14216155 22.20 ENSRNOT00000020192
Hagh
hydroxyacyl glutathione hydrolase
chr10_-_14215957 21.14 ENSRNOT00000019767
Fahd1
fumarylacetoacetate hydrolase domain containing 1
chr7_-_70452675 19.66 ENSRNOT00000090498
AC114111.1

chr9_+_100281339 18.35 ENSRNOT00000029127
Agxt
alanine-glyoxylate aminotransferase
chr13_+_49074644 17.13 ENSRNOT00000000041
Klhdc8a
kelch domain containing 8A
chr19_-_43911057 15.46 ENSRNOT00000026017
Ctrb1
chymotrypsinogen B1
chr7_+_11301957 13.91 ENSRNOT00000027847
Tjp3
tight junction protein 3
chr4_-_161907767 13.71 ENSRNOT00000009557
A2ml1
alpha-2-macroglobulin-like 1
chr11_-_57993548 13.65 ENSRNOT00000002957
Nectin3
nectin cell adhesion molecule 3
chr12_-_39396042 13.30 ENSRNOT00000001746
P2rx7
purinergic receptor P2X 7
chr2_+_197682000 11.77 ENSRNOT00000066821
Hormad1
HORMA domain containing 1
chr7_+_64672722 11.38 ENSRNOT00000064448
ENSRNOT00000005539
Grip1
glutamate receptor interacting protein 1
chr7_-_140770647 10.95 ENSRNOT00000081784
C1ql4
complement C1q like 4
chr4_+_157107469 9.75 ENSRNOT00000015678
C1rl
complement C1r subcomponent like
chr16_+_81665540 9.30 ENSRNOT00000026546
ENSRNOT00000092644
ENSRNOT00000073240
Grtp1
growth hormone regulated TBC protein 1
chr20_+_41266566 8.61 ENSRNOT00000000653
Frk
fyn-related Src family tyrosine kinase
chr12_-_2277169 8.48 ENSRNOT00000078078
Clec4g
C-type lectin domain family 4, member G
chr8_+_57886168 7.44 ENSRNOT00000039336
Exph5
exophilin 5
chr1_+_99532568 6.79 ENSRNOT00000077073
Zfp819
zinc finger protein 819
chr7_+_70452579 6.78 ENSRNOT00000046099
B4galnt1
beta-1,4-N-acetyl-galactosaminyl transferase 1
chr11_-_69355854 6.60 ENSRNOT00000002975
Ropn1
rhophilin associated tail protein 1
chr1_+_78671121 6.22 ENSRNOT00000021310
Ap2s1
adaptor-related protein complex 2, sigma 1 subunit
chr13_-_72869396 6.04 ENSRNOT00000093563
RGD1304622
similar to 6820428L09 protein
chr8_+_71719563 5.59 ENSRNOT00000022828
Ppib
peptidylprolyl isomerase B
chr1_+_85252103 5.46 ENSRNOT00000080740
Ifnl1
interferon, lambda 1
chr11_-_28478360 5.38 ENSRNOT00000032663
Cldn17
claudin 17
chr19_-_44095250 4.77 ENSRNOT00000074824
Tmem170a
transmembrane protein 170A
chr19_-_52424318 4.70 ENSRNOT00000021743
Tldc1
TBC/LysM-associated domain containing 1
chr19_-_39087880 4.61 ENSRNOT00000070822
Chtf8
chromosome transmission fidelity factor 8
chr1_-_85237775 4.51 ENSRNOT00000035328
Ifnl3
interferon, lambda 3
chr3_+_11679530 4.29 ENSRNOT00000074562
ENSRNOT00000071801
Eng
endoglin
chr4_-_125808281 3.96 ENSRNOT00000037848
Magi1
membrane associated guanylate kinase, WW and PDZ domain containing 1
chr10_+_44506098 3.83 ENSRNOT00000078135
LOC501698
similar to olfactory receptor Olr1448
chr9_-_99680979 3.80 ENSRNOT00000049347
Olr1345
olfactory receptor 1345
chr4_-_7113919 3.61 ENSRNOT00000014082
Chpf2
chondroitin polymerizing factor 2
chr10_+_20591432 3.18 ENSRNOT00000059780
Pank3
pantothenate kinase 3
chr3_+_119783717 2.73 ENSRNOT00000039043
Astl
astacin like metalloendopeptidase
chrX_-_139229702 2.30 ENSRNOT00000042507
AABR07041771.1

chr2_-_154508877 2.09 ENSRNOT00000086472
RGD1565059
similar to hypothetical protein E130311K13
chr1_-_174620064 2.06 ENSRNOT00000016224
Tmem41b
transmembrane protein 41B
chr1_+_204861566 1.86 ENSRNOT00000023214
Fam175b
family with sequence similarity 175, member B
chr1_+_277190964 1.86 ENSRNOT00000080511
Casp7
caspase 7
chr10_-_34961349 1.58 ENSRNOT00000004885
LOC103689931
heterogeneous nuclear ribonucleoprotein A/B
chr3_+_143084563 1.49 ENSRNOT00000006362
Cstl1
cystatin-like 1
chr5_+_157434481 1.23 ENSRNOT00000088556
Tmco4
transmembrane and coiled-coil domains 4
chr3_-_148104483 1.17 ENSRNOT00000055406
Defb25
defensin beta 25
chr10_+_55169282 0.99 ENSRNOT00000005423
Ccdc42
coiled-coil domain containing 42
chr15_-_58711872 0.96 ENSRNOT00000058204
Serp2
stress-associated endoplasmic reticulum protein family member 2
chr10_-_37055282 0.84 ENSRNOT00000086193
ENSRNOT00000065584
Hnrnpab
heterogeneous nuclear ribonucleoprotein A/B
chr19_+_49462129 0.75 ENSRNOT00000015158
Cenpn
centromere protein N
chr14_-_89179507 0.69 ENSRNOT00000006498
Pkd1l1
polycystin 1 like 1, transient receptor potential channel interacting
chr10_+_105861743 0.54 ENSRNOT00000064410
Mgat5b
mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B
chrX_+_70256737 0.53 ENSRNOT00000029298
Otud6a
OTU deubiquitinase 6A
chr1_-_242373764 0.51 ENSRNOT00000076544
Fam122a
family with sequence similarity 122A
chr6_-_117972898 0.02 ENSRNOT00000032968
AABR07065265.1

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
19.4 58.1 GO:0046416 D-amino acid metabolic process(GO:0046416)
7.4 22.2 GO:0072566 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
7.3 29.1 GO:0072218 ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218)
6.1 18.4 GO:0019265 glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) oxalic acid secretion(GO:0046724)
4.4 22.2 GO:0061727 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
4.4 13.3 GO:0043132 phospholipid transfer to membrane(GO:0006649) NAD transport(GO:0043132) regulation of bleb assembly(GO:1904170)
4.2 45.9 GO:0015747 urate transport(GO:0015747)
3.7 33.4 GO:0071279 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
2.0 30.0 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
1.9 5.6 GO:1901873 regulation of post-translational protein modification(GO:1901873)
1.7 11.8 GO:0042138 meiotic DNA double-strand break formation(GO:0042138)
1.5 13.7 GO:1902414 protein localization to cell junction(GO:1902414)
1.4 4.3 GO:1905072 cardiac jelly development(GO:1905072)
1.4 5.5 GO:0042509 negative regulation of interleukin-13 production(GO:0032696) regulation of tyrosine phosphorylation of STAT protein(GO:0042509) positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
1.4 6.8 GO:0001574 ganglioside biosynthetic process(GO:0001574)
0.9 2.7 GO:2000359 regulation of binding of sperm to zona pellucida(GO:2000359) negative regulation of binding of sperm to zona pellucida(GO:2000360)
0.5 4.6 GO:1900264 regulation of DNA-directed DNA polymerase activity(GO:1900262) positive regulation of DNA-directed DNA polymerase activity(GO:1900264)
0.5 27.1 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.5 8.5 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.4 7.4 GO:0003334 keratinocyte development(GO:0003334)
0.4 1.9 GO:0072734 response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
0.3 4.8 GO:0051292 nuclear pore complex assembly(GO:0051292)
0.3 9.7 GO:0006958 complement activation, classical pathway(GO:0006958)
0.3 6.6 GO:0048240 sperm capacitation(GO:0048240)
0.2 11.0 GO:0048147 negative regulation of fibroblast proliferation(GO:0048147)
0.2 15.5 GO:0032094 response to food(GO:0032094)
0.2 0.8 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
0.2 1.9 GO:0070417 cellular response to cold(GO:0070417)
0.2 4.7 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.2 4.5 GO:0002385 mucosal immune response(GO:0002385)
0.2 0.5 GO:1990167 protein K27-linked deubiquitination(GO:1990167) protein K33-linked deubiquitination(GO:1990168)
0.2 3.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 9.3 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.1 8.3 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 15.2 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.7 GO:0070986 left/right axis specification(GO:0070986)
0.0 0.7 GO:0034508 centromere complex assembly(GO:0034508)
0.0 13.7 GO:0016567 protein ubiquitination(GO:0016567)
0.0 0.9 GO:0030968 endoplasmic reticulum unfolded protein response(GO:0030968)
0.0 1.5 GO:2000045 regulation of G1/S transition of mitotic cell cycle(GO:2000045)
0.0 4.0 GO:0070997 neuron death(GO:0070997)
0.0 1.6 GO:0001837 epithelial to mesenchymal transition(GO:0001837)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 33.4 GO:0043203 axon hillock(GO:0043203)
1.6 6.2 GO:0030121 AP-1 adaptor complex(GO:0030121)
1.5 13.3 GO:0032059 bleb(GO:0032059)
1.1 6.6 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
1.1 27.1 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.9 18.4 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.9 58.1 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.5 4.6 GO:0031390 Ctf18 RFC-like complex(GO:0031390)
0.5 5.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 45.9 GO:0031526 brush border membrane(GO:0031526)
0.3 1.9 GO:0036449 microtubule minus-end(GO:0036449)
0.2 20.7 GO:0032587 ruffle membrane(GO:0032587)
0.2 17.1 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 11.8 GO:0000795 synaptonemal complex(GO:0000795)
0.2 36.9 GO:0043296 apical junction complex(GO:0043296)
0.2 30.0 GO:0030658 transport vesicle membrane(GO:0030658)
0.1 6.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 0.8 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.1 11.4 GO:0055037 recycling endosome(GO:0055037)
0.1 1.6 GO:0019013 viral nucleocapsid(GO:0019013)
0.1 22.2 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 8.3 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.8 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 56.5 GO:0005615 extracellular space(GO:0005615)
0.0 4.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 0.7 GO:0034704 calcium channel complex(GO:0034704)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.0 21.1 GO:0008948 oxaloacetate decarboxylase activity(GO:0008948) hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
4.6 45.9 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
4.4 22.2 GO:0004416 hydroxyacylglutathione hydrolase activity(GO:0004416)
3.7 18.4 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
2.5 58.1 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
2.5 22.2 GO:0022833 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
1.5 13.3 GO:0004931 extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381)
1.1 29.1 GO:0071837 HMG box domain binding(GO:0071837)
1.1 27.1 GO:0004383 guanylate cyclase activity(GO:0004383)
0.9 4.3 GO:0005534 galactose binding(GO:0005534)
0.8 3.2 GO:0004594 pantothenate kinase activity(GO:0004594)
0.6 30.0 GO:0030507 spectrin binding(GO:0030507)
0.6 11.4 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.5 4.6 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.4 10.4 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.4 8.5 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.3 33.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 15.2 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 0.5 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
0.1 8.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 5.6 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 25.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 4.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 11.4 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 17.1 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 5.1 GO:0005125 cytokine activity(GO:0005125)
0.0 2.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.4 GO:0008565 protein transporter activity(GO:0008565)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 22.2 PID P73PATHWAY p73 transcription factor network
0.2 38.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 5.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 4.3 PID ALK1 PATHWAY ALK1 signaling events
0.1 19.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.9 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 45.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
1.1 13.3 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.6 15.5 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 6.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.4 76.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 44.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 3.2 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.2 5.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 3.6 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 5.6 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 1.9 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.7 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere