ISMARA results: Zkscan3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zkscan3

Z-value: 0.90

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Transcription factors associated with Zkscan3

Gene Symbol	Gene ID	Gene Info
Zkscan3 NCBI RGD Ensembl	ENSRNOG00000055000	zinc finger with KRAB and SCAN domains 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zkscan3	rn6_v1_chr17_+_45247776_45247794	-0.31	1.2e-08	Click!

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_48365784 Show fit	58.14	ENSRNOT00000077317	Dao NCBI RGD Ensembl Show fit	D-amino-acid oxidase
chr1_-_221917901 Show fit	45.94	ENSRNOT00000092270	Slc22a12 NCBI RGD Ensembl Show fit	solute carrier family 22 member 12
chr3_-_94686989 Show fit	44.74	ENSRNOT00000016677	Depdc7 NCBI RGD Ensembl Show fit	DEP domain containing 7
chr10_-_62254287 Show fit	33.44	ENSRNOT00000004313	Serpinf1 NCBI RGD Ensembl Show fit	serpin family F member 1
chr9_-_82461903 Show fit	29.99	ENSRNOT00000026654	Ptprn NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, receptor type, N
chr9_+_49479023 Show fit	29.08	ENSRNOT00000050922 ENSRNOT00000077111	Pou3f3 NCBI RGD Ensembl Show fit	POU class 3 homeobox 3
chr4_-_148845267 Show fit	28.41	ENSRNOT00000037397	Tmem72 NCBI RGD Ensembl Show fit	transmembrane protein 72
chr15_-_45550285 Show fit	27.06	ENSRNOT00000012948	Gucy1b2 NCBI RGD Ensembl Show fit	guanylate cyclase 1 soluble subunit beta 2
chr9_-_71852113 Show fit	25.28	ENSRNOT00000083263 ENSRNOT00000072983	AABR07067896.1 NCBI RGD Ensembl Show fit
chr12_+_47698947 Show fit	22.23	ENSRNOT00000001586	Trpv4 NCBI RGD Ensembl Show fit	transient receptor potential cation channel, subfamily V, member 4

Showing 1 to 10 of 65 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
19.4	58.1	GO:0046416	D-amino acid metabolic process(GO:0046416)
4.2	45.9	GO:0015747	urate transport(GO:0015747)
3.7	33.4	GO:0071279	negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770) cellular response to cobalt ion(GO:0071279)
2.0	30.0	GO:0061469	regulation of type B pancreatic cell proliferation(GO:0061469)
7.3	29.1	GO:0072218	ascending thin limb development(GO:0072021) metanephric ascending thin limb development(GO:0072218)
0.5	27.1	GO:0006182	cGMP biosynthetic process(GO:0006182)
7.4	22.2	GO:0072566	hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477) chemokine (C-X-C motif) ligand 1 production(GO:0072566) regulation of chemokine (C-X-C motif) ligand 1 production(GO:2000338)
4.4	22.2	GO:0061727	methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione(GO:0019243) methylglyoxal catabolic process(GO:0051596) methylglyoxal catabolic process to lactate(GO:0061727)
6.1	18.4	GO:0019265	glycine biosynthetic process, by transamination of glyoxylate(GO:0019265) oxalic acid secretion(GO:0046724)
0.2	15.5	GO:0032094	response to food(GO:0032094)

Showing 1 to 10 of 42 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	58.1	GO:0044439	microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.0	56.5	GO:0005615	extracellular space(GO:0005615)
0.5	45.9	GO:0031526	brush border membrane(GO:0031526)
0.2	36.9	GO:0043296	apical junction complex(GO:0043296)
4.2	33.4	GO:0043203	axon hillock(GO:0043203)
0.2	30.0	GO:0030658	transport vesicle membrane(GO:0030658)
1.1	27.1	GO:0008074	guanylate cyclase complex, soluble(GO:0008074)
0.1	22.2	GO:0005759	mitochondrial matrix(GO:0005759)
0.2	20.7	GO:0032587	ruffle membrane(GO:0032587)
0.9	18.4	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)

Showing 1 to 10 of 26 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	58.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
4.6	45.9	GO:1901702	urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3	33.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.6	30.0	GO:0030507	spectrin binding(GO:0030507)
1.1	29.1	GO:0071837	HMG box domain binding(GO:0071837)
1.1	27.1	GO:0004383	guanylate cyclase activity(GO:0004383)
0.1	25.2	GO:0004252	serine-type endopeptidase activity(GO:0004252)
4.4	22.2	GO:0004416	hydroxyacylglutathione hydrolase activity(GO:0004416)
2.5	22.2	GO:0022833	mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
7.0	21.1	GO:0008948	oxaloacetate decarboxylase activity(GO:0008948) hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)

Showing 1 to 10 of 28 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.1	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	22.2	PID P73PATHWAY	p73 transcription factor network
0.1	19.4	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1	5.6	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.1	4.3	PID ALK1 PATHWAY	ALK1 signaling events
0.0	1.9	PID A6B1 A6B4 INTEGRIN PATHWAY	a6b1 and a6b4 Integrin signaling

Showing 1 to 6 of 6 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	76.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
4.2	45.9	REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT	Genes involved in Organic cation/anion/zwitterion transport
0.3	44.7	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.6	15.5	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.1	13.3	REACTOME THE NLRP3 INFLAMMASOME	Genes involved in The NLRP3 inflammasome
0.4	6.2	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.1	5.6	REACTOME EXTRACELLULAR MATRIX ORGANIZATION	Genes involved in Extracellular matrix organization
0.2	5.4	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.2	3.6	REACTOME CHONDROITIN SULFATE BIOSYNTHESIS	Genes involved in Chondroitin sulfate biosynthesis
0.2	3.2	REACTOME VITAMIN B5 PANTOTHENATE METABOLISM	Genes involved in Vitamin B5 (pantothenate) metabolism

Showing 1 to 10 of 12 entries

Results for Zkscan3

Z-value: 0.90

Motif logo

Transcription factors associated with Zkscan3

Activity-expression correlation:

Activity profile of Zkscan3 motif

Sorted Z-values of Zkscan3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zkscan3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: