ISMARA results: Zic2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zic2

Z-value: 0.95

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Transcription factors associated with Zic2

Gene Symbol	Gene ID	Gene Info
Zic2 NCBI RGD Ensembl	ENSRNOG00000054879	Zic family member 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zic2	rn6_v1_chr15_+_108908607_108908607	-0.11	5.2e-02	Click!

Activity profile of Zic2 motif

Sorted Z-values of Zic2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_57855416 Show fit	20.40	ENSRNOT00000029608	Cpa2 NCBI RGD Ensembl Show fit	carboxypeptidase A2
chr6_+_139551751 Show fit	20.16	ENSRNOT00000081684	AABR07065699.2 NCBI RGD Ensembl Show fit
chr8_-_49308806 Show fit	19.82	ENSRNOT00000047291	Cd3e NCBI RGD Ensembl Show fit	CD3e molecule
chr5_-_160403373 Show fit	17.73	ENSRNOT00000018393	Ctrc NCBI RGD Ensembl Show fit	chymotrypsin C
chr1_+_279867034 Show fit	15.74	ENSRNOT00000024164	Pnliprp1 NCBI RGD Ensembl Show fit	pancreatic lipase-related protein 1
chr4_-_69268336 Show fit	15.51	ENSRNOT00000018042	Prss3b NCBI RGD Ensembl Show fit	protease, serine, 3B
chr3_+_17107861 Show fit	15.22	ENSRNOT00000043097	AABR07051563.1 NCBI RGD Ensembl Show fit
chr6_-_139719323 Show fit	15.01	ENSRNOT00000090133	AABR07065705.4 NCBI RGD Ensembl Show fit
chr3_+_16817051 Show fit	14.84	ENSRNOT00000071666	AABR07051550.1 NCBI RGD Ensembl Show fit
chr14_-_100217913 Show fit	14.79	ENSRNOT00000079167	Plek NCBI RGD Ensembl Show fit	pleckstrin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.3	19.8	GO:0002913	positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
1.0	19.5	GO:0046415	urate metabolic process(GO:0046415)
3.1	18.5	GO:0071314	cellular response to cocaine(GO:0071314)
3.7	14.8	GO:0070560	protein secretion by platelet(GO:0070560)
2.1	14.8	GO:0051256	mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.1	12.5	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
4.1	12.4	GO:0045082	positive regulation of interleukin-10 biosynthetic process(GO:0045082)
0.4	12.0	GO:0043552	positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
2.0	11.9	GO:0021633	optic nerve structural organization(GO:0021633)
0.1	11.8	GO:0031016	pancreas development(GO:0031016)

Showing 1 to 10 of 263 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	59.7	GO:0045095	keratin filament(GO:0045095)
0.0	55.4	GO:0005615	extracellular space(GO:0005615)
0.2	22.5	GO:0072562	blood microparticle(GO:0072562)
2.5	19.8	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.7	18.4	GO:0000788	nuclear nucleosome(GO:0000788)
5.9	17.8	GO:0097124	cyclin A2-CDK2 complex(GO:0097124)
1.0	15.9	GO:0044224	juxtaparanode region of axon(GO:0044224)
0.5	13.4	GO:0042629	mast cell granule(GO:0042629)
0.1	12.0	GO:0005741	mitochondrial outer membrane(GO:0005741)
0.5	11.8	GO:0005732	small nucleolar ribonucleoprotein complex(GO:0005732)

Showing 1 to 10 of 111 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	63.1	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.3	31.4	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.8	21.4	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
0.3	17.2	GO:0005044	scavenger receptor activity(GO:0005044)
0.6	14.9	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.5	14.5	GO:0097472	cyclin-dependent protein kinase activity(GO:0097472)
0.1	14.3	GO:0031490	chromatin DNA binding(GO:0031490)
1.6	14.2	GO:0043515	kinetochore binding(GO:0043515)
0.2	13.7	GO:0016279	lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.3	13.5	GO:0001784	phosphotyrosine binding(GO:0001784)

Showing 1 to 10 of 209 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	32.7	PID IL4 2PATHWAY	IL4-mediated signaling events
1.7	28.3	SA REG CASCADE OF CYCLIN EXPR	Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.5	22.1	PID UPA UPAR PATHWAY	Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
0.6	20.1	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4
0.2	15.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.3	12.9	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.2	12.9	SIG CHEMOTAXIS	Genes related to chemotaxis
0.8	10.7	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
0.6	10.6	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.4	8.6	PID CD40 PATHWAY	CD40/CD40L signaling

Showing 1 to 10 of 43 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.5	26.9	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
2.5	19.8	REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE	Genes involved in Translocation of ZAP-70 to Immunological synapse
1.2	18.6	REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION	Genes involved in Cyclin A/B1 associated events during G2/M transition
0.4	11.8	REACTOME KINESINS	Genes involved in Kinesins
0.2	11.5	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.5	10.4	REACTOME INITIAL TRIGGERING OF COMPLEMENT	Genes involved in Initial triggering of complement
0.2	10.1	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
0.3	9.9	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters
0.7	9.5	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors

Showing 1 to 10 of 85 entries

Results for Zic2

Z-value: 0.95

Motif logo

Transcription factors associated with Zic2

Activity-expression correlation:

Activity profile of Zic2 motif

Sorted Z-values of Zic2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zic2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: