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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zfp691

Z-value: 1.33

Motif logo

Transcription factors associated with Zfp691

Gene Symbol Gene ID Gene Info
ENSRNOG00000007398 zinc finger protein 691

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zfp691rn6_v1_chr5_-_138222534_138222534-0.344.2e-10Click!

Activity profile of Zfp691 motif

Sorted Z-values of Zfp691 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_32811135 61.37 ENSRNOT00000067689

chr11_-_37914983 54.47 ENSRNOT00000039876
myxovirus (influenza virus) resistance 1
chr10_-_110232843 46.72 ENSRNOT00000054934
Cd7 molecule
chr14_-_15258207 46.23 ENSRNOT00000039383
C-X-C motif chemokine ligand 13
chr13_+_50164563 45.85 ENSRNOT00000029533
lymphocyte transmembrane adaptor 1
chr6_-_138662365 44.89 ENSRNOT00000066209
ENSRNOT00000084892
immunoglobulin heavy constant mu
chr6_+_139486942 42.66 ENSRNOT00000080320

chr6_-_138900915 40.33 ENSRNOT00000075363

chr6_+_139486775 39.95 ENSRNOT00000077771

chr10_-_31359699 37.88 ENSRNOT00000081280
cytoplasmic FMR1 interacting protein 2
chr8_-_49308806 37.78 ENSRNOT00000047291
CD3e molecule
chrX_-_71169038 36.24 ENSRNOT00000005343
interleukin 2 receptor subunit gamma
chr6_+_139560028 35.45 ENSRNOT00000072633
rCG58847-like
chr6_+_139428999 34.47 ENSRNOT00000084482

chrX_-_71168612 32.98 ENSRNOT00000075934
interleukin 2 receptor subunit gamma
chr11_+_71872830 32.60 ENSRNOT00000050364
negative regulator of reactive oxygen species
chr13_-_91981432 31.35 ENSRNOT00000004637

chr7_+_125288081 31.25 ENSRNOT00000085216
parvin, gamma
chr15_-_29548400 31.18 ENSRNOT00000078176

chr6_+_139293130 30.98 ENSRNOT00000071714
Ighg protein-like
chr6_-_138931262 30.92 ENSRNOT00000078126
ENSRNOT00000042118
Ighg protein-like
chr6_-_139004980 28.14 ENSRNOT00000085427
ENSRNOT00000087351

chr8_+_133210473 27.41 ENSRNOT00000082774
chemokine (C-C motif) receptor 5
chr6_-_139660666 26.44 ENSRNOT00000086098

chr6_-_139710905 26.37 ENSRNOT00000077430

chr6_-_138954741 24.80 ENSRNOT00000083278

chr6_+_139293294 24.14 ENSRNOT00000050297
ENSRNOT00000081817
Ighg protein-like
chr6_-_138954577 24.08 ENSRNOT00000042728

chr8_-_22270647 24.02 ENSRNOT00000028380
sphingosine-1-phosphate receptor 5
chr10_-_90415070 23.54 ENSRNOT00000055179
integrin subunit alpha 2b
chr10_-_67401836 22.98 ENSRNOT00000073071
cytokine receptor-like factor 3
chr11_+_60383431 22.77 ENSRNOT00000093295
Cd200 molecule
chr13_-_26768708 22.23 ENSRNOT00000092763
BCL2, apoptosis regulator
chr1_-_133559975 21.12 ENSRNOT00000046645
multiple C2 and transmembrane domain containing 2
chr20_-_32232632 21.04 ENSRNOT00000068184
DExD-box helicase 21
chrX_+_1311121 20.86 ENSRNOT00000038909
complement factor properdin
chr1_+_215628785 20.44 ENSRNOT00000054864
lymphocyte-specific protein 1
chr10_-_13619935 20.06 ENSRNOT00000064392
cyclin F
chr16_-_21362955 19.72 ENSRNOT00000039607
Gem-interacting protein
chr20_-_32139789 19.45 ENSRNOT00000078140
serglycin
chr14_-_14426437 19.15 ENSRNOT00000068134
annexin A3
chr8_+_132869712 18.89 ENSRNOT00000008294
C-X-C motif chemokine receptor 6
chr6_-_139637187 18.66 ENSRNOT00000089454
Ighg protein-like
chr10_-_14613878 18.56 ENSRNOT00000024072
BAI1-associated protein 3
chr3_-_7202848 18.17 ENSRNOT00000078428
growth factor independent 1B transcriptional repressor
chr1_-_13050644 18.17 ENSRNOT00000081259
hdc homolog, cell cycle regulator
chr3_-_7203420 17.87 ENSRNOT00000015236
growth factor independent 1B transcriptional repressor
chr3_+_2591331 17.74 ENSRNOT00000017466
suppressor APC domain containing 2
chr7_-_60860990 17.54 ENSRNOT00000009511
RAP1B, member of RAS oncogene family
chr6_-_139637354 16.85 ENSRNOT00000072900
Ighg protein-like
chr1_+_256955652 15.90 ENSRNOT00000020411
leucine-rich, glioma inactivated 1
chr14_+_5928737 15.59 ENSRNOT00000071877
ENSRNOT00000040985
ENSRNOT00000074889
macrophage activation 2 like
chr19_+_37600148 14.96 ENSRNOT00000023853
CCCTC-binding factor
chr15_-_108326907 14.90 ENSRNOT00000016848
G protein-coupled receptor 18
chr19_-_9843673 14.82 ENSRNOT00000015795
GINS complex subunit 3
chr6_-_138931429 14.72 ENSRNOT00000090584
Ighg protein-like
chr1_-_227505267 13.53 ENSRNOT00000028443
membrane spanning 4-domains A7
chr8_+_113105814 13.28 ENSRNOT00000016749
copine 4
chr5_+_47894530 12.15 ENSRNOT00000076035
ENSRNOT00000090799
midasin AAA ATPase 1
chr1_+_61553449 10.25 ENSRNOT00000068694
similar to 60S ribosomal protein L18a
chr7_+_143060597 9.45 ENSRNOT00000087481
keratin 7
chr20_-_6548179 8.83 ENSRNOT00000093711
LEM domain containing 2
chr1_+_124983452 8.60 ENSRNOT00000021262
transient receptor potential cation channel, subfamily M, member 1
chr7_-_2961873 8.15 ENSRNOT00000067441
ribosomal protein S15, pseudogene 2
chr16_+_61926586 7.85 ENSRNOT00000058884

chr5_+_150725654 7.78 ENSRNOT00000089852
ENSRNOT00000017740
DnaJ heat shock protein family (Hsp40) member C8
chr20_-_44255064 7.76 ENSRNOT00000000735
WNT1 inducible signaling pathway protein 3
chr12_+_13102019 7.71 ENSRNOT00000092628
ras-related C3 botulinum toxin substrate 1
chr7_-_132984110 7.53 ENSRNOT00000046626
high mobility group box 1, pseudogene 3
chr18_+_83777665 7.48 ENSRNOT00000018682
cerebellin 2 precursor
chr8_-_32431987 7.30 ENSRNOT00000048460
similar to 60S ribosomal protein L32
chr1_-_226630900 7.23 ENSRNOT00000028092
transmembrane protein 138
chr8_-_62386264 7.19 ENSRNOT00000026165
complexin 3
chrX_+_156429585 6.91 ENSRNOT00000083203
ENSRNOT00000077322
deoxyribonuclease 1-like 1
chr7_+_2458833 6.89 ENSRNOT00000085092
nascent polypeptide-associated complex alpha subunit
chr1_-_170579616 6.69 ENSRNOT00000076100
ribosomal RNA processing 8, methyltransferase, homolog (yeast)
chr18_+_3705916 6.55 ENSRNOT00000092846
laminin subunit alpha 3
chr6_+_91697109 6.42 ENSRNOT00000006355
ADP-ribosylation factor 6
chr2_+_230186198 6.33 ENSRNOT00000013049
ENSRNOT00000092954
caspase 6
chr1_-_94404211 6.32 ENSRNOT00000019463
URI1, prefoldin-like chaperone
chr2_+_235341365 6.26 ENSRNOT00000078017
ENSRNOT00000090658
caspase-6
chr1_-_199336451 6.16 ENSRNOT00000035672
protease, serine, 53
chr5_-_173659675 6.04 ENSRNOT00000027547
kelch-like family member 17
chr11_-_71419223 5.90 ENSRNOT00000002407
transferrin receptor
chr20_+_13680716 5.31 ENSRNOT00000029458
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1
chr5_+_147069616 5.19 ENSRNOT00000072908
tripartite motif-containing 62
chr4_+_140377565 5.18 ENSRNOT00000082723
inositol 1,4,5-trisphosphate receptor, type 1
chr8_-_133002201 5.01 ENSRNOT00000008772
C-C motif chemokine receptor 1
chr12_-_18274515 4.99 ENSRNOT00000078075
sialophorin-like
chr3_-_176716146 4.78 ENSRNOT00000017668
src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites
chr16_-_20278814 4.74 ENSRNOT00000025385
microtubule-associated protein 1S
chr10_-_40994872 4.72 ENSRNOT00000058640
similar to High mobility group protein 1 (HMG-1)
chr2_-_116374584 4.57 ENSRNOT00000058919
leucine-rich repeats and IQ motif containing 4
chr9_+_94310921 4.53 ENSRNOT00000026646
eukaryotic translation initiation factor 4E family member 2
chr14_+_48740190 4.44 ENSRNOT00000031638
ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2
chr9_-_65387169 4.39 ENSRNOT00000051843
origin recognition complex, subunit 2
chr8_+_59111271 4.26 ENSRNOT00000029413
SH2 domain containing 7
chr11_-_71619167 4.24 ENSRNOT00000002396
transmembrane 4 L six family member 19
chr5_+_135574172 4.21 ENSRNOT00000023416
testis-specific kinase 2
chr6_-_91490366 4.05 ENSRNOT00000059187
dynein, axonemal, assembly factor 2
chr7_-_28932641 3.97 ENSRNOT00000059487
DNA-damage regulated autophagy modulator 1
chr3_-_161131812 3.95 ENSRNOT00000067008
WAP four-disulfide core domain 11
chr8_-_22086095 3.90 ENSRNOT00000068598
zinc finger, GATA-like protein 1
chr12_-_46493203 3.84 ENSRNOT00000057036
citron rho-interacting serine/threonine kinase
chr10_+_4719713 3.70 ENSRNOT00000003412
lipopolysaccharide-induced TNF factor
chr12_-_2170504 3.44 ENSRNOT00000001309
XPA binding protein 2
chr4_+_147455533 3.43 ENSRNOT00000081957
tRNA splicing endonuclease subunit 2
chr2_+_187990242 3.27 ENSRNOT00000092819
Rho/Rac guanine nucleotide exchange factor 2
chr13_-_55886679 3.04 ENSRNOT00000066601
similar to novel protein
chr19_+_53723822 3.01 ENSRNOT00000023478
similar to RIKEN cDNA 6430548M08
chr12_-_22472044 2.86 ENSRNOT00000073356
UFM1-specific peptidase 1
chr1_-_213907144 2.81 ENSRNOT00000054874
single Ig and TIR domain containing
chr9_-_10659357 2.74 ENSRNOT00000091450
lysine demethylase 4B
chr5_+_173340487 2.73 ENSRNOT00000078306
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3
chr20_-_43108198 2.68 ENSRNOT00000000742
histone deacetylase 2
chr13_+_68949665 2.63 ENSRNOT00000003320
family with sequence similarity 129, member A
chr2_-_94903226 2.60 ENSRNOT00000015194

chr20_+_11863082 2.58 ENSRNOT00000001640
family with sequence similarity 207, member A
chr1_+_125367280 2.27 ENSRNOT00000022049
amyloid beta precursor protein binding family A member 2
chr2_+_204886202 2.26 ENSRNOT00000022200
nerve growth factor
chrX_-_20807216 2.23 ENSRNOT00000075757
family with sequence similarity 156, member B
chr6_-_98606109 1.96 ENSRNOT00000006860
WD repeat domain 89
chr4_+_78140483 1.96 ENSRNOT00000048576
zinc finger protein 862
chr4_+_168396775 1.91 ENSRNOT00000008645
BLOC-1 related complex subunit 5
chr9_+_94310469 1.75 ENSRNOT00000065743
eukaryotic translation initiation factor 4E family member 2
chr7_+_125940323 1.72 ENSRNOT00000083830
family with sequence similarity 118, member A
chr12_-_11294058 1.63 ENSRNOT00000001319
actin related protein 2/3 complex, subunit 1A
chr3_+_80081647 1.45 ENSRNOT00000057161
ADP-ribosylation factor GTPase activating protein 2
chr15_+_42808897 1.43 ENSRNOT00000023475
cholinergic receptor nicotinic alpha 2 subunit
chr15_+_19690194 1.36 ENSRNOT00000010612
serine/threonine/tyrosine interacting protein
chr1_+_220840118 1.24 ENSRNOT00000027927
FGF1 intracellular binding protein
chr5_+_135882967 1.18 ENSRNOT00000024841
eukaryotic translation initiation factor 2B, subunit 3 gamma
chr15_-_28835796 1.06 ENSRNOT00000060439
olfactory receptor 1641
chr9_+_92859988 0.83 ENSRNOT00000085332
calcium binding protein 39
chr5_+_18901039 0.80 ENSRNOT00000012066
family with sequence similarity 110, member B
chr10_+_63635219 0.80 ENSRNOT00000081813
ENSRNOT00000005016
pre-mRNA processing factor 8
chr2_-_188216482 0.73 ENSRNOT00000027579
misato 1, mitochondrial distribution and morphology regulator
chr2_-_157066781 0.73 ENSRNOT00000001187
similar to RalA binding protein 1
chr3_+_4233111 0.72 ENSRNOT00000042910
lipocalin 1
chr11_+_30550141 0.67 ENSRNOT00000002866
hormonally upregulated Neu-associated kinase
chr3_+_63536166 0.64 ENSRNOT00000016132
pleckstrin homology domain containing A3
chr3_-_22459257 0.61 ENSRNOT00000091747
DENN domain containing 1A
chrX_+_157854272 0.55 ENSRNOT00000089777
ENSRNOT00000003145
family with sequence similarity 122B
chr11_-_28598179 0.48 ENSRNOT00000070889
keratin-associated protein 26-1-like
chr13_+_49195325 0.46 ENSRNOT00000004810
dual serine/threonine and tyrosine protein kinase
chr11_-_11214141 0.43 ENSRNOT00000065748
roundabout guidance receptor 2
chr2_+_20431243 0.25 ENSRNOT00000021857
single-stranded DNA binding protein 2
chr11_-_87403367 0.03 ENSRNOT00000057751
THAP domain containing 7

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp691

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.6 46.2 GO:2001027 negative regulation of endothelial cell chemotaxis(GO:2001027)
9.4 37.8 GO:0002913 positive regulation of T cell anergy(GO:0002669) positive regulation of lymphocyte anergy(GO:0002913)
9.1 27.4 GO:2000464 positive regulation of astrocyte chemotaxis(GO:2000464)
7.4 22.2 GO:0019740 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) negative regulation of retinal cell programmed cell death(GO:0046671)
6.9 69.2 GO:0032831 regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032829) positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0032831)
6.5 19.5 GO:0033364 mast cell secretory granule organization(GO:0033364)
6.1 54.5 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
5.0 40.1 GO:0051388 positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388)
4.5 36.0 GO:0051572 negative regulation of histone H3-K4 methylation(GO:0051572)
3.5 17.5 GO:2000301 negative regulation of synaptic vesicle exocytosis(GO:2000301)
3.3 20.1 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
2.5 22.8 GO:0043031 negative regulation of macrophage activation(GO:0043031)
2.3 6.9 GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
1.9 15.0 GO:0016584 maintenance of DNA methylation(GO:0010216) nucleosome positioning(GO:0016584)
1.7 45.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
1.6 24.0 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
1.5 7.7 GO:0032707 negative regulation of interleukin-23 production(GO:0032707)
1.4 14.9 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
1.3 6.3 GO:0072733 acute inflammatory response to non-antigenic stimulus(GO:0002525) response to staurosporine(GO:0072733) cellular response to staurosporine(GO:0072734)
1.2 19.1 GO:0043312 neutrophil degranulation(GO:0043312)
1.1 46.7 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.9 2.8 GO:0045079 negative regulation of chemokine biosynthetic process(GO:0045079)
0.9 2.7 GO:0006344 maintenance of chromatin silencing(GO:0006344)
0.9 5.2 GO:0002433 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.9 3.4 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
0.8 6.7 GO:0046015 regulation of transcription by glucose(GO:0046015)
0.8 3.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.8 8.8 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.8 8.6 GO:0046548 retinal rod cell development(GO:0046548)
0.7 5.9 GO:0033572 transferrin transport(GO:0033572)
0.7 10.0 GO:0031498 chromatin disassembly(GO:0031498)
0.6 23.0 GO:1904894 positive regulation of JAK-STAT cascade(GO:0046427) positive regulation of STAT cascade(GO:1904894)
0.5 19.7 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.5 32.6 GO:0006801 superoxide metabolic process(GO:0006801)
0.5 21.0 GO:0010501 RNA secondary structure unwinding(GO:0010501) response to exogenous dsRNA(GO:0043330)
0.4 23.9 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.4 6.4 GO:0036010 protein localization to endosome(GO:0036010)
0.3 6.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 3.4 GO:0006283 transcription-coupled nucleotide-excision repair(GO:0006283)
0.3 2.7 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.3 21.2 GO:0070527 platelet aggregation(GO:0070527)
0.3 31.3 GO:0031532 actin cytoskeleton reorganization(GO:0031532)
0.3 6.9 GO:0006308 DNA catabolic process(GO:0006308)
0.2 5.2 GO:0010719 negative regulation of epithelial to mesenchymal transition(GO:0010719)
0.2 3.8 GO:0050774 negative regulation of dendrite morphogenesis(GO:0050774)
0.2 4.1 GO:0001539 cilium or flagellum-dependent cell motility(GO:0001539) cilium-dependent cell motility(GO:0060285)
0.2 3.7 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.1 0.6 GO:0032483 regulation of Rab protein signal transduction(GO:0032483)
0.1 7.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.1 15.9 GO:0030307 positive regulation of cell growth(GO:0030307)
0.1 0.8 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.1 18.2 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.1 7.5 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 4.8 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.1 3.9 GO:0048599 oocyte development(GO:0048599)
0.1 4.2 GO:0048041 cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041)
0.1 6.3 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.1 0.5 GO:0045743 positive regulation of fibroblast growth factor receptor signaling pathway(GO:0045743)
0.1 7.5 GO:0006413 translational initiation(GO:0006413)
0.1 1.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 2.3 GO:0016079 synaptic vesicle exocytosis(GO:0016079)
0.0 1.4 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.7 GO:0048311 mitochondrion distribution(GO:0048311)
0.0 1.9 GO:0032418 lysosome localization(GO:0032418)
0.0 1.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 7.2 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 4.6 GO:0006260 DNA replication(GO:0006260)
0.0 0.7 GO:0001895 retina homeostasis(GO:0001895)
0.0 2.6 GO:0001933 negative regulation of protein phosphorylation(GO:0001933)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
4.7 37.8 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
2.9 8.6 GO:0035838 growing cell tip(GO:0035838)
1.3 6.7 GO:0033553 rDNA heterochromatin(GO:0033553)
1.3 5.2 GO:0031088 platelet dense granule membrane(GO:0031088)
1.1 19.1 GO:0042581 specific granule(GO:0042581)
1.1 6.5 GO:0005608 laminin-3 complex(GO:0005608)
1.0 5.9 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.7 19.5 GO:0042629 mast cell granule(GO:0042629)
0.7 3.4 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
0.7 23.5 GO:0008305 integrin complex(GO:0008305)
0.6 7.7 GO:0060091 kinocilium(GO:0060091)
0.5 4.4 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.5 1.9 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.5 8.8 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229)
0.4 2.7 GO:0090571 RNA polymerase II transcription repressor complex(GO:0090571)
0.4 6.4 GO:0031527 filopodium membrane(GO:0031527)
0.4 6.3 GO:0005845 mRNA cap binding complex(GO:0005845)
0.3 6.3 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.3 36.0 GO:0016363 nuclear matrix(GO:0016363)
0.3 91.5 GO:0009897 external side of plasma membrane(GO:0009897)
0.3 1.6 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.2 16.6 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 5.3 GO:0090544 BAF-type complex(GO:0090544)
0.2 1.2 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.2 14.6 GO:0005811 lipid particle(GO:0005811)
0.2 2.3 GO:0005796 Golgi lumen(GO:0005796)
0.2 6.0 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 2.7 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.2 7.8 GO:0045171 intercellular bridge(GO:0045171)
0.1 23.0 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 9.4 GO:0045095 keratin filament(GO:0045095)
0.1 15.0 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 12.1 GO:0045111 intermediate filament cytoskeleton(GO:0045111)
0.1 34.6 GO:0098857 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 62.9 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.1 3.3 GO:0002102 podosome(GO:0002102)
0.1 4.2 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 1.1 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 4.6 GO:0034702 ion channel complex(GO:0034702)
0.0 3.8 GO:0031985 Golgi cisterna(GO:0031985)
0.0 14.0 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 4.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 9.5 GO:0098793 presynapse(GO:0098793)
0.0 10.9 GO:0005774 vacuolar membrane(GO:0005774)
0.0 4.0 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 10.6 GO:0031012 extracellular matrix(GO:0031012)
0.0 60.0 GO:0005654 nucleoplasm(GO:0005654)
0.0 34.5 GO:0044421 extracellular region part(GO:0044421)
0.0 9.0 GO:0005887 integral component of plasma membrane(GO:0005887)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.4 46.2 GO:0031735 CCR10 chemokine receptor binding(GO:0031735)
11.5 69.2 GO:0019976 interleukin-2 binding(GO:0019976)
10.8 32.4 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
3.9 23.5 GO:0070051 fibrinogen binding(GO:0070051)
3.8 19.1 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
3.7 22.2 GO:0051434 BH3 domain binding(GO:0051434)
3.0 21.0 GO:0097322 7SK snRNA binding(GO:0097322)
2.4 24.0 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
2.4 18.9 GO:0019958 C-X-C chemokine binding(GO:0019958)
2.0 6.0 GO:0031208 POZ domain binding(GO:0031208)
1.3 5.2 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.0 45.9 GO:0042169 SH2 domain binding(GO:0042169)
0.9 2.7 GO:0035851 Krueppel-associated box domain binding(GO:0035851)
0.9 7.7 GO:0051022 Rho GDP-dissociation inhibitor binding(GO:0051022)
0.7 3.4 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
0.7 5.9 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.6 2.3 GO:0005163 nerve growth factor receptor binding(GO:0005163)
0.5 6.3 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.4 6.4 GO:0031996 thioesterase binding(GO:0031996)
0.4 4.6 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.3 21.1 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.3 4.4 GO:0003688 DNA replication origin binding(GO:0003688)
0.3 2.7 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.3 86.3 GO:0003924 GTPase activity(GO:0003924)
0.3 38.4 GO:0017124 SH3 domain binding(GO:0017124)
0.3 7.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.3 6.9 GO:0017025 TBP-class protein binding(GO:0017025)
0.3 39.9 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)
0.2 19.5 GO:0005518 collagen binding(GO:0005518)
0.2 6.3 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.2 7.2 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.2 20.1 GO:0031490 chromatin DNA binding(GO:0031490)
0.2 11.6 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.1 8.9 GO:0035064 methylated histone binding(GO:0035064)
0.1 3.7 GO:0050699 WW domain binding(GO:0050699)
0.1 7.5 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 4.7 GO:0004712 protein serine/threonine/tyrosine kinase activity(GO:0004712)
0.1 28.3 GO:0005096 GTPase activator activity(GO:0005096)
0.1 4.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 0.8 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 1.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.7 GO:0031404 chloride ion binding(GO:0031404)
0.1 1.4 GO:0042166 acetylcholine binding(GO:0042166)
0.1 6.3 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.1 8.3 GO:0005262 calcium channel activity(GO:0005262)
0.1 2.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 3.8 GO:0097110 scaffold protein binding(GO:0097110)
0.1 1.2 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.0 21.8 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 2.9 GO:0019783 ubiquitin-like protein-specific protease activity(GO:0019783)
0.0 0.8 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.0 0.6 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.0 1.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 9.5 GO:0050839 cell adhesion molecule binding(GO:0050839)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 69.2 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
2.0 22.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.6 24.0 PID S1P S1P4 PATHWAY S1P4 pathway
1.3 69.5 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
1.3 46.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
1.1 65.2 PID IL12 2PATHWAY IL12-mediated signaling events
1.0 23.5 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.9 20.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.7 31.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.7 46.7 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.5 19.5 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 6.5 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.3 6.3 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.3 5.2 ST GAQ PATHWAY G alpha q Pathway
0.3 2.3 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 4.4 PID ARF6 PATHWAY Arf6 signaling events
0.1 3.3 PID REELIN PATHWAY Reelin signaling pathway
0.1 19.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.9 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 3.8 PID RHOA PATHWAY RhoA signaling pathway
0.1 30.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 13.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 2.7 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 0.8 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 27.4 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
5.4 37.8 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
4.6 69.2 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
2.3 41.1 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.5 70.1 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
1.2 22.2 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.9 54.5 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.5 7.7 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.4 4.4 REACTOME E2F ENABLED INHIBITION OF PRE REPLICATION COMPLEX FORMATION Genes involved in E2F-enabled inhibition of pre-replication complex formation
0.2 19.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 6.3 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.2 5.9 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 2.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.2 26.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.4 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 3.4 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.1 6.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 8.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 0.8 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 2.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 2.8 REACTOME MYD88 MAL CASCADE INITIATED ON PLASMA MEMBRANE Genes involved in MyD88:Mal cascade initiated on plasma membrane
0.0 2.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events