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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Zfp652
Z-value: 0.94
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Transcription factors associated with Zfp652
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp652 | rn6_v1_chr10_+_83556809_83556809 | 0.15 | 5.6e-03 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr7_-_140483693 Show fit | 45.06 |
ENSRNOT00000089060
|
dendrin |
|
| chrX_+_107496072 Show fit | 44.51 |
ENSRNOT00000003283
|
proteolipid protein 1 |
|
| chr8_+_55178289 Show fit | 43.55 |
ENSRNOT00000059127
|
crystallin, alpha B |
|
| chr10_-_51778939 Show fit | 29.20 |
ENSRNOT00000078675
ENSRNOT00000057562 |
myocardin |
|
| chr8_-_58542844 Show fit | 26.67 |
ENSRNOT00000012041
|
ELMO domain containing 1 |
|
| chr6_+_119519714 Show fit | 25.52 |
ENSRNOT00000004955
|
fibronectin leucine rich transmembrane protein 2 |
|
| chr5_-_152473868 Show fit | 25.29 |
ENSRNOT00000022130
|
family with sequence similarity 110, member D |
|
| chr6_-_42473738 Show fit | 24.52 |
ENSRNOT00000033327
|
potassium voltage-gated channel modifier subfamily F member 1 |
|
| chr18_-_61057365 Show fit | 22.86 |
ENSRNOT00000042352
|
alpha-kinase 2 |
|
| chr2_+_187344056 Show fit | 22.48 |
ENSRNOT00000025314
|
nestin |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zfp652
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 43.6 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 1.0 | 38.6 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 2.5 | 37.5 | GO:0042759 | long-chain fatty acid biosynthetic process(GO:0042759) |
| 2.8 | 31.3 | GO:0046710 | GDP metabolic process(GO:0046710) |
| 9.7 | 29.2 | GO:0001560 | regulation of cell growth by extracellular stimulus(GO:0001560) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721) |
| 4.3 | 25.5 | GO:0061343 | cell adhesion involved in heart morphogenesis(GO:0061343) |
| 0.7 | 22.6 | GO:0010738 | regulation of protein kinase A signaling(GO:0010738) |
| 5.6 | 22.5 | GO:0045105 | intermediate filament polymerization or depolymerization(GO:0045105) |
| 5.4 | 21.4 | GO:0043397 | corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397) |
| 0.3 | 21.4 | GO:0051298 | centrosome duplication(GO:0051298) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 60.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 3.0 | 45.1 | GO:0032591 | dendritic spine membrane(GO:0032591) |
| 0.4 | 44.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.2 | 44.5 | GO:0043209 | myelin sheath(GO:0043209) |
| 4.8 | 43.6 | GO:0097512 | cardiac myofibril(GO:0097512) |
| 0.1 | 26.0 | GO:0005925 | focal adhesion(GO:0005925) |
| 8.6 | 25.8 | GO:0098855 | HCN channel complex(GO:0098855) |
| 0.7 | 24.9 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 22.9 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 1.0 | 22.5 | GO:0016581 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.7 | 44.5 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 2.0 | 43.1 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 4.8 | 38.6 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 3.1 | 31.3 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 1.0 | 29.2 | GO:0070412 | R-SMAD binding(GO:0070412) |
| 0.1 | 26.7 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 2.6 | 25.8 | GO:0005222 | intracellular cAMP activated cation channel activity(GO:0005222) |
| 2.1 | 25.5 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 5.0 | 25.0 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.0 | 22.9 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.1 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.3 | 21.4 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.4 | 15.8 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 13.0 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.4 | 11.3 | ST GA12 PATHWAY | G alpha 12 Pathway |
| 0.2 | 10.6 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.2 | 10.4 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.4 | 6.7 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.1 | 6.2 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
| 0.0 | 4.6 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 37.2 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.5 | 33.1 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 0.7 | 19.4 | REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS | Genes involved in Regulation of gene expression in beta cells |
| 1.2 | 18.1 | REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX | Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex |
| 0.6 | 17.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 1.1 | 15.8 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.2 | 10.9 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 8.4 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.1 | 6.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.1 | 6.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |