ISMARA results: Zfp524

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zfp524

Z-value: 1.19

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Transcription factors associated with Zfp524

Gene Symbol	Gene ID	Gene Info
Zfp524 NCBI RGD Ensembl	ENSRNOG00000016565	zinc finger protein 524

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zfp524	rn6_v1_chr1_-_72377434_72377434	0.45	3.6e-17	Click!

Activity profile of Zfp524 motif

Sorted Z-values of Zfp524 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_89386023 Show fit	31.94	ENSRNOT00000086223	Fcgr3a NCBI RGD Ensembl Show fit	Fc fragment of IgG receptor IIIa
chr13_+_89385859 Show fit	29.46	ENSRNOT00000047434	Fcgr3a NCBI RGD Ensembl Show fit	Fc fragment of IgG receptor IIIa
chr3_-_80012750 Show fit	26.58	ENSRNOT00000018154	Nr1h3 NCBI RGD Ensembl Show fit	nuclear receptor subfamily 1, group H, member 3
chr19_+_24456976 Show fit	26.49	ENSRNOT00000004900	Ucp1 NCBI RGD Ensembl Show fit	uncoupling protein 1
chr4_+_99239115 Show fit	25.55	ENSRNOT00000009515	Cd8a NCBI RGD Ensembl Show fit	CD8a molecule
chr1_-_73619356 Show fit	24.78	ENSRNOT00000074352	Lilrb3 NCBI RGD Ensembl Show fit	leukocyte immunoglobulin like receptor B3
chr17_+_24416651 Show fit	24.14	ENSRNOT00000024458	Cd83 NCBI RGD Ensembl Show fit	CD83 molecule
chr13_+_83996080 Show fit	22.71	ENSRNOT00000004403 ENSRNOT00000070958	Cd247 NCBI RGD Ensembl Show fit	Cd247 molecule
chr13_-_50499060 Show fit	21.83	ENSRNOT00000065347 ENSRNOT00000076924	Etnk2 NCBI RGD Ensembl Show fit	ethanolamine kinase 2
chr9_-_9985358 Show fit	20.51	ENSRNOT00000080856	Crb3 NCBI RGD Ensembl Show fit	crumbs 3, cell polarity complex component

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp524

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.3	78.8	GO:0038094	Fc-gamma receptor signaling pathway(GO:0038094)
1.7	28.6	GO:0036297	interstrand cross-link repair(GO:0036297)
2.5	27.8	GO:0031936	negative regulation of chromatin silencing(GO:0031936)
1.8	27.5	GO:0002024	diet induced thermogenesis(GO:0002024)
0.4	27.2	GO:0050852	T cell receptor signaling pathway(GO:0050852)
5.3	26.6	GO:0048550	negative regulation of pinocytosis(GO:0048550)
8.5	25.5	GO:0045065	cytotoxic T cell differentiation(GO:0045065)
5.1	25.5	GO:0032747	positive regulation of interleukin-23 production(GO:0032747)
3.6	25.5	GO:1904996	positive regulation of leukocyte adhesion to vascular endothelial cell(GO:1904996)
0.9	24.8	GO:0045671	negative regulation of osteoclast differentiation(GO:0045671)

Showing 1 to 10 of 370 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	139.3	GO:0009897	external side of plasma membrane(GO:0009897)
6.9	55.2	GO:0042105	alpha-beta T cell receptor complex(GO:0042105)
0.3	38.6	GO:0005884	actin filament(GO:0005884)
0.0	35.0	GO:0005654	nucleoplasm(GO:0005654)
0.2	32.7	GO:0031965	nuclear membrane(GO:0031965)
0.2	31.1	GO:0044798	nuclear transcription factor complex(GO:0044798)
0.2	27.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3	27.0	GO:0031526	brush border membrane(GO:0031526)
0.7	26.9	GO:0001772	immunological synapse(GO:0001772)
0.4	25.3	GO:0005811	lipid particle(GO:0005811)

Showing 1 to 10 of 170 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
15.8	78.8	GO:0019770	IgG receptor activity(GO:0019770)
0.3	35.3	GO:0017124	SH3 domain binding(GO:0017124)
10.0	29.9	GO:0032810	sterol response element binding(GO:0032810)
1.3	28.8	GO:0030676	Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.2	28.6	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.4	27.3	GO:1990782	protein tyrosine kinase binding(GO:1990782)
6.6	26.5	GO:0017077	oxidative phosphorylation uncoupler activity(GO:0017077)
1.3	26.5	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
4.9	24.4	GO:0015440	peptide-transporting ATPase activity(GO:0015440)
2.0	24.2	GO:0022820	potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)

Showing 1 to 10 of 262 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.9	123.3	PID CD8 TCR PATHWAY	TCR signaling in naïve CD8+ T cells
3.8	68.1	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.5	33.4	PID LYMPH ANGIOGENESIS PATHWAY	VEGFR3 signaling in lymphatic endothelium
0.7	29.9	PID RXR VDR PATHWAY	RXR and RAR heterodimerization with other nuclear receptor
0.8	25.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.7	23.8	PID IL1 PATHWAY	IL1-mediated signaling events
0.3	23.5	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.9	22.3	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.3	18.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.6	17.6	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events

Showing 1 to 10 of 56 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	157.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
5.1	56.0	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.9	44.1	REACTOME FATTY ACYL COA BIOSYNTHESIS	Genes involved in Fatty Acyl-CoA Biosynthesis
0.6	35.2	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
1.0	34.5	REACTOME STEROID HORMONES	Genes involved in Steroid hormones
0.9	31.2	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
0.4	24.9	REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY	Genes involved in Nuclear Receptor transcription pathway
0.7	23.9	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
0.2	23.5	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	22.7	REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION	Genes involved in Glucagon signaling in metabolic regulation

Showing 1 to 10 of 103 entries

Results for Zfp524

Z-value: 1.19

Motif logo

Transcription factors associated with Zfp524

Activity-expression correlation:

Activity profile of Zfp524 motif

Sorted Z-values of Zfp524 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zfp524

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: