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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb7c

Z-value: 0.63

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Transcription factors associated with Zbtb7c

Gene Symbol Gene ID Gene Info
Zbtb7c
ENSRNOG00000047924 zinc finger and BTB domain containing 7C

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Zbtb7crn6_v1_chr18_+_72005581_72005581-0.081.8e-01Click!

Activity profile of Zbtb7c motif

Sorted Z-values of Zbtb7c motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_88122233 74.84 ENSRNOT00000083895
ENSRNOT00000005285
Krt14
keratin 14
chr10_-_88050622 55.75 ENSRNOT00000019037
Krt15
keratin 15
chr5_+_152681101 23.00 ENSRNOT00000076052
ENSRNOT00000022574
Stmn1
stathmin 1
chr15_+_104095179 20.15 ENSRNOT00000093487
Cldn10
claudin 10
chr1_+_224824799 9.31 ENSRNOT00000024757
Slc22a6
solute carrier family 22 member 6
chr3_+_172856733 7.50 ENSRNOT00000009826
Edn3
endothelin 3
chr3_+_154043873 6.51 ENSRNOT00000072502
ENSRNOT00000034166
Nnat
neuronatin
chr4_-_184096806 6.05 ENSRNOT00000055433
LOC100362344
mKIAA1238 protein-like
chr1_+_104576589 5.23 ENSRNOT00000046529
Nav2
neuron navigator 2
chr10_+_55013703 4.99 ENSRNOT00000032785
Pik3r5
phosphoinositide-3-kinase, regulatory subunit 5
chrX_+_15049462 4.41 ENSRNOT00000007015
Ebp
emopamil binding protein (sterol isomerase)
chr16_+_9563218 3.84 ENSRNOT00000035915
Arhgap22
Rho GTPase activating protein 22
chr10_+_92289107 3.82 ENSRNOT00000050070
Mapt
microtubule-associated protein tau
chr12_-_37425596 3.16 ENSRNOT00000084553
Tctn2
tectonic family member 2
chr1_-_259106948 3.05 ENSRNOT00000074429
LOC100912537
tectonic-3-like
chr5_-_127983515 3.03 ENSRNOT00000043054
Fam159a
family with sequence similarity 159, member A
chrX_-_124766044 3.01 ENSRNOT00000000177
Lamp2
lysosomal-associated membrane protein 2
chr15_-_34693034 2.98 ENSRNOT00000083314
Mcpt8
mast cell protease 8
chr3_+_146582752 2.96 ENSRNOT00000010157
Pygb
glycogen phosphorylase B
chr10_+_57185347 2.71 ENSRNOT00000040488
ENSRNOT00000086374
Mink1
misshapen-like kinase 1
chr17_-_44420596 2.67 ENSRNOT00000077512
RGD1561897
similar to Serine/threonine-protein kinase Kist (Kinase interacting with stathmin)
chr13_-_88536728 2.65 ENSRNOT00000003950
Uhmk1
U2AF homology motif kinase 1
chrX_-_158739838 2.57 ENSRNOT00000003091
Phf6
PHD finger protein 6
chr19_+_25969255 2.46 ENSRNOT00000004370
Farsa
phenylalanyl-tRNA synthetase, alpha subunit
chr1_+_169590308 2.45 ENSRNOT00000023147
Olr155
olfactory receptor 155
chr7_+_53878610 2.39 ENSRNOT00000091910
Osbpl8
oxysterol binding protein-like 8
chr10_+_59360765 2.36 ENSRNOT00000036278
Zzef1
zinc finger ZZ-type and EF-hand domain containing 1
chr5_+_22392732 2.24 ENSRNOT00000087182
Clvs1
clavesin 1
chr20_-_6961162 2.18 ENSRNOT00000000635
Mtch1
mitochondrial carrier 1
chr5_-_139921013 2.07 ENSRNOT00000079957
Smap2
small ArfGAP2
chr8_+_73682887 1.90 ENSRNOT00000057522
Vps13c
vacuolar protein sorting 13C
chr20_-_6960481 1.73 ENSRNOT00000093172
Mtch1
mitochondrial carrier 1
chrX_-_128268285 1.68 ENSRNOT00000009755
ENSRNOT00000081880
Thoc2
THO complex 2
chr5_+_26493212 1.60 ENSRNOT00000061328
Triqk
triple QxxK/R motif containing
chr5_+_142845114 1.57 ENSRNOT00000039870
Yrdc
yrdC N(6)-threonylcarbamoyltransferase domain containing
chr10_+_20320878 1.57 ENSRNOT00000009714
Slit3
slit guidance ligand 3
chr10_+_65448950 1.26 ENSRNOT00000082348
ENSRNOT00000037016
Rab34
RAB34, member RAS oncogene family
chr4_-_132740938 1.21 ENSRNOT00000007185
Rybp
RING1 and YY1 binding protein
chr13_-_72367980 1.15 ENSRNOT00000003928
Cacna1e
calcium voltage-gated channel subunit alpha1 E
chr12_+_41543696 1.14 ENSRNOT00000079639
Tpcn1
two pore segment channel 1
chr10_+_104118945 1.09 ENSRNOT00000005035
Nup85
nucleoporin 85
chr1_-_214844858 1.04 ENSRNOT00000046344
Tollip
toll interacting protein
chr2_-_24923128 0.87 ENSRNOT00000044087
Pde8b
phosphodiesterase 8B
chr8_+_72029489 0.76 ENSRNOT00000089336
Herc1
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
chr14_+_38192870 0.71 ENSRNOT00000077080
Nfxl1
nuclear transcription factor, X-box binding-like 1
chr3_-_72445775 0.69 ENSRNOT00000033427
ENSRNOT00000077573
P2rx3
purinergic receptor P2X 3
chr10_-_59360661 0.65 ENSRNOT00000036942
Cyb5d2
cytochrome b5 domain containing 2
chr4_+_176994129 0.44 ENSRNOT00000018734
Cmas
cytidine monophosphate N-acetylneuraminic acid synthetase
chr12_+_21981755 0.39 ENSRNOT00000001871
LOC100910540
7SK snRNA methylphosphate capping enzyme-like
chr3_-_113231790 0.30 ENSRNOT00000019025
Tp53bp1
tumor protein p53 binding protein 1
chr2_-_198852161 0.25 ENSRNOT00000028815
Polr3c
RNA polymerase III subunit C
chr9_-_43022998 0.18 ENSRNOT00000063781
ENSRNOT00000089843
Lman2l
lectin, mannose-binding 2-like
chr5_-_36683356 0.07 ENSRNOT00000009043
Pou3f2
POU class 3 homeobox 2
chr4_+_133285552 0.04 ENSRNOT00000029115
Ppp4r2
protein phosphatase 4, regulatory subunit 2
chr3_-_95418679 0.02 ENSRNOT00000018074
Rcn1
reticulocalbin 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb7c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
12.5 74.8 GO:0045110 intermediate filament bundle assembly(GO:0045110)
5.7 23.0 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
1.9 7.5 GO:0014826 vein smooth muscle contraction(GO:0014826)
1.6 9.3 GO:0031427 response to methotrexate(GO:0031427)
1.3 5.2 GO:0021564 vagus nerve development(GO:0021564)
1.1 53.9 GO:0045103 intermediate filament-based process(GO:0045103)
1.0 3.0 GO:1905146 protein targeting to lysosome involved in chaperone-mediated autophagy(GO:0061740) lysosomal protein catabolic process(GO:1905146)
0.6 2.4 GO:0090204 protein localization to nuclear pore(GO:0090204)
0.5 1.6 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.5 2.5 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.5 3.8 GO:0090258 negative regulation of mitochondrial fission(GO:0090258) regulation of cellular response to heat(GO:1900034)
0.5 3.2 GO:1904491 protein localization to ciliary transition zone(GO:1904491)
0.4 1.6 GO:0021834 chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration(GO:0021834)
0.3 1.9 GO:1904923 regulation of mitophagy in response to mitochondrial depolarization(GO:1904923)
0.2 0.9 GO:0035106 operant conditioning(GO:0035106)
0.2 2.7 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.2 1.7 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.1 1.1 GO:0090273 regulation of somatostatin secretion(GO:0090273)
0.1 1.3 GO:0044351 macropinocytosis(GO:0044351) phagosome-lysosome fusion(GO:0090385)
0.1 3.0 GO:0044247 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
0.1 2.7 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.1 5.0 GO:0043551 regulation of phosphatidylinositol 3-kinase activity(GO:0043551)
0.1 4.4 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.1 1.2 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.1 6.5 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.1 1.0 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 3.9 GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0006919)
0.0 0.4 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.0 2.2 GO:0080171 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 0.8 GO:0021702 cerebellar Purkinje cell differentiation(GO:0021702)
0.0 1.1 GO:0048246 macrophage chemotaxis(GO:0048246)
0.0 1.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.0 0.3 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 3.0 GO:0016485 protein processing(GO:0016485)
0.0 0.1 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 128.8 GO:0045095 keratin filament(GO:0045095)
1.7 5.0 GO:0005944 phosphatidylinositol 3-kinase complex, class IB(GO:0005944)
1.0 3.0 GO:0031166 integral component of vacuolar membrane(GO:0031166) intrinsic component of vacuolar membrane(GO:0031310) lysosomal matrix(GO:1990836)
1.0 3.8 GO:0045298 tubulin complex(GO:0045298)
0.8 2.5 GO:0009328 phenylalanine-tRNA ligase complex(GO:0009328)
0.4 2.7 GO:0089701 U2AF(GO:0089701)
0.3 5.2 GO:0005614 interstitial matrix(GO:0005614)
0.2 3.2 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.4 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.2 1.7 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 20.2 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.1 GO:0031080 nuclear pore outer ring(GO:0031080)
0.1 9.3 GO:0005901 caveola(GO:0005901)
0.0 19.1 GO:0005874 microtubule(GO:0005874)
0.0 1.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 2.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 1.1 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.0 0.9 GO:0031519 PcG protein complex(GO:0031519)
0.0 0.2 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.0 1.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 2.7 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 4.3 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
15.0 74.8 GO:1990254 keratin filament binding(GO:1990254)
2.5 7.5 GO:0031708 endothelin B receptor binding(GO:0031708)
2.0 6.1 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
1.5 4.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
1.2 9.3 GO:0031404 chloride ion binding(GO:0031404)
1.0 3.0 GO:0008184 glycogen phosphorylase activity(GO:0008184)
1.0 3.8 GO:0099609 microtubule lateral binding(GO:0099609)
0.8 5.0 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.6 54.4 GO:0097110 scaffold protein binding(GO:0097110)
0.6 1.1 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
0.4 2.5 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.3 2.7 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.2 1.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.2 1.6 GO:0048495 Roundabout binding(GO:0048495)
0.1 2.4 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 1.0 GO:0035325 Toll-like receptor binding(GO:0035325)
0.1 2.2 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.9 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.1 1.3 GO:0017160 Ral GTPase binding(GO:0017160)
0.1 23.0 GO:0015631 tubulin binding(GO:0015631)
0.1 1.1 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 0.4 GO:0070567 cytidylyltransferase activity(GO:0070567)
0.0 1.6 GO:0000049 tRNA binding(GO:0000049)
0.0 3.2 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 5.9 GO:0005096 GTPase activator activity(GO:0005096)
0.0 2.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.2 GO:0001056 RNA polymerase III activity(GO:0001056)
0.0 2.7 GO:0008201 heparin binding(GO:0008201)
0.0 3.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 26.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.1 72.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 5.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 7.5 PID ENDOTHELIN PATHWAY Endothelins
0.1 4.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 1.0 PID IL1 PATHWAY IL1-mediated signaling events
0.0 0.9 PID E2F PATHWAY E2F transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 9.3 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.6 20.2 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 4.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 5.0 REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA Genes involved in G beta:gamma signalling through PI3Kgamma
0.1 3.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.1 3.8 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 2.5 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 7.5 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 1.1 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
0.0 1.6 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 3.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 3.8 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.2 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation