ISMARA results: Zbtb6

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb6

Z-value: 0.98

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Transcription factors associated with Zbtb6

Gene Symbol	Gene ID	Gene Info
Zbtb6 NCBI RGD Ensembl	ENSRNOG00000009340	zinc finger and BTB domain containing 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zbtb6	rn6_v1_chr3_-_21684132_21684132	0.27	6.2e-07	Click!

Activity profile of Zbtb6 motif

Sorted Z-values of Zbtb6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr3_-_105279462 Show fit	53.16	ENSRNOT00000010679	Scg5 NCBI RGD Ensembl Show fit	secretogranin V
chr10_-_103816287 Show fit	49.02	ENSRNOT00000004477	Grin2c NCBI RGD Ensembl Show fit	glutamate ionotropic receptor NMDA type subunit 2C
chr1_-_31122093 Show fit	46.33	ENSRNOT00000016712	NEWGENE_1307525 NCBI RGD Ensembl Show fit	SOGA family member 3
chr10_-_90999506 Show fit	45.22	ENSRNOT00000034401	Gfap NCBI RGD Ensembl Show fit	glial fibrillary acidic protein
chr17_+_88215834 Show fit	42.96	ENSRNOT00000034098	Gpr158 NCBI RGD Ensembl Show fit	G protein-coupled receptor 158
chr10_-_27366665 Show fit	42.37	ENSRNOT00000004725	Gabra1 NCBI RGD Ensembl Show fit	gamma-aminobutyric acid type A receptor alpha1 subunit
chr2_+_174013288 Show fit	29.51	ENSRNOT00000013904	Serpini1 NCBI RGD Ensembl Show fit	serpin family I member 1
chr12_-_23925741 Show fit	28.85	ENSRNOT00000001957	Srrm3 NCBI RGD Ensembl Show fit	serine/arginine repetitive matrix 3
chr16_-_18937562 Show fit	27.22	ENSRNOT00000080387	Nwd1 NCBI RGD Ensembl Show fit	NACHT and WD repeat domain containing 1
chr7_+_78092037 Show fit	26.93	ENSRNOT00000050753	Rims2 NCBI RGD Ensembl Show fit	regulating synaptic membrane exocytosis 2

Showing 1 to 10 of 190 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	53.2	GO:0016486	peptide hormone processing(GO:0016486)
16.3	49.0	GO:0033058	directional locomotion(GO:0033058)
7.5	45.2	GO:0010625	positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
3.1	43.2	GO:0071420	cellular response to histamine(GO:0071420)
0.2	43.0	GO:0072659	protein localization to plasma membrane(GO:0072659)
2.3	32.5	GO:1904322	response to forskolin(GO:1904321) cellular response to forskolin(GO:1904322)
0.1	27.6	GO:0010976	positive regulation of neuron projection development(GO:0010976)
2.1	26.9	GO:0061669	spontaneous neurotransmitter secretion(GO:0061669) spontaneous synaptic transmission(GO:0098814)
2.1	25.2	GO:0036005	response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
4.2	25.1	GO:0097116	gephyrin clustering involved in postsynaptic density assembly(GO:0097116)

Showing 1 to 10 of 110 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	50.8	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
2.9	49.0	GO:0017146	NMDA selective glutamate receptor complex(GO:0017146)
11.3	45.2	GO:0098574	cytoplasmic side of lysosomal membrane(GO:0098574)
1.8	42.4	GO:1902711	GABA receptor complex(GO:1902710) GABA-A receptor complex(GO:1902711)
0.1	38.2	GO:0030141	secretory granule(GO:0030141)
1.1	36.5	GO:0060077	inhibitory synapse(GO:0060077)
0.3	29.3	GO:0030672	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1	27.7	GO:0043025	neuronal cell body(GO:0043025)
0.7	27.4	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
0.1	25.6	GO:0016323	basolateral plasma membrane(GO:0016323)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	50.1	GO:0051082	unfolded protein binding(GO:0051082)
6.1	49.0	GO:0004972	NMDA glutamate receptor activity(GO:0004972)
0.1	48.3	GO:0005509	calcium ion binding(GO:0005509)
8.5	42.4	GO:0008503	benzodiazepine receptor activity(GO:0008503) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
0.4	40.9	GO:0005200	structural constituent of cytoskeleton(GO:0005200)
0.2	33.0	GO:0044325	ion channel binding(GO:0044325)
0.3	29.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
4.4	26.6	GO:0004568	chitinase activity(GO:0004568)
6.3	25.2	GO:0048101	calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
3.6	25.1	GO:0097109	neuroligin family protein binding(GO:0097109)

Showing 1 to 10 of 87 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	29.5	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.8	24.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
0.4	24.1	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.4	15.0	PID EPHA FWDPATHWAY	EPHA forward signaling
0.3	14.3	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	14.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	12.9	PID LKB1 PATHWAY	LKB1 signaling events
0.3	10.4	PID REELIN PATHWAY	Reelin signaling pathway
0.7	10.0	PID S1P S1P4 PATHWAY	S1P4 pathway
0.2	7.3	PID IL12 STAT4 PATHWAY	IL12 signaling mediated by STAT4

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	49.0	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.8	45.2	REACTOME NUCLEAR SIGNALING BY ERBB4	Genes involved in Nuclear signaling by ERBB4
2.5	42.4	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.3	32.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
1.0	25.2	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.6	20.2	REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING	Genes involved in Role of second messengers in netrin-1 signaling
0.1	19.2	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.7	17.4	REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR	Genes involved in Prostacyclin signalling through prostacyclin receptor
0.7	16.5	REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS	Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
1.0	15.0	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle

Showing 1 to 10 of 38 entries

Results for Zbtb6

Z-value: 0.98

Motif logo

Transcription factors associated with Zbtb6

Activity-expression correlation:

Activity profile of Zbtb6 motif

Sorted Z-values of Zbtb6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb6

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: