ISMARA results: Zbtb4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb4

Z-value: 0.84

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Transcription factors associated with Zbtb4

Gene Symbol	Gene ID	Gene Info
Zbtb4 NCBI RGD Ensembl	ENSRNOG00000014689	zinc finger and BTB domain containing 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zbtb4	rn6_v1_chr10_+_56381813_56381813	-0.47	3.7e-19	Click!

Activity profile of Zbtb4 motif

Sorted Z-values of Zbtb4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_263803150 Show fit	55.99	ENSRNOT00000017840	Cyp2c23 NCBI RGD Ensembl Show fit	cytochrome P450, family 2, subfamily c, polypeptide 23
chr17_-_417480 Show fit	55.00	ENSRNOT00000023685	Fbp1 NCBI RGD Ensembl Show fit	fructose-bisphosphatase 1
chrX_+_143097525 Show fit	42.98	ENSRNOT00000004559	F9 NCBI RGD Ensembl Show fit	coagulation factor IX
chr13_+_78805347 Show fit	36.80	ENSRNOT00000003748	Serpinc1 NCBI RGD Ensembl Show fit	serpin family C member 1
chr16_-_7007287 Show fit	35.32	ENSRNOT00000041216	Itih3 NCBI RGD Ensembl Show fit	inter-alpha trypsin inhibitor, heavy chain 3
chr16_-_7007051 Show fit	32.97	ENSRNOT00000023984	Itih3 NCBI RGD Ensembl Show fit	inter-alpha trypsin inhibitor, heavy chain 3
chr9_+_80118029 Show fit	29.20	ENSRNOT00000023068	Igfbp2 NCBI RGD Ensembl Show fit	insulin-like growth factor binding protein 2
chr7_-_2677199 Show fit	28.82	ENSRNOT00000043908	Apon NCBI RGD Ensembl Show fit	apolipoprotein N
chr12_+_52452273 Show fit	28.36	ENSRNOT00000056680 ENSRNOT00000088381	Pxmp2 NCBI RGD Ensembl Show fit	peroxisomal membrane protein 2
chr7_-_119623072 Show fit	26.21	ENSRNOT00000050511	Tst NCBI RGD Ensembl Show fit	thiosulfate sulfurtransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.2	68.3	GO:0030212	hyaluronan metabolic process(GO:0030212)
2.1	56.0	GO:0019373	epoxygenase P450 pathway(GO:0019373)
13.7	55.0	GO:0046351	disaccharide biosynthetic process(GO:0046351)
0.3	43.0	GO:0031638	zymogen activation(GO:0031638)
9.2	36.8	GO:0007597	blood coagulation, intrinsic pathway(GO:0007597)
1.0	27.5	GO:0043567	regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
8.7	26.2	GO:0035928	rRNA import into mitochondrion(GO:0035928)
7.8	23.4	GO:0070634	transepithelial ammonium transport(GO:0070634)
2.8	22.0	GO:0006578	amino-acid betaine biosynthetic process(GO:0006578)
1.1	21.6	GO:0050908	detection of light stimulus involved in visual perception(GO:0050908) detection of light stimulus involved in sensory perception(GO:0050962)

Showing 1 to 10 of 123 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	200.9	GO:0070062	extracellular exosome(GO:0070062)
0.5	62.8	GO:0072562	blood microparticle(GO:0072562)
0.1	48.8	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.1	47.0	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
1.5	28.4	GO:0031231	integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.2	25.3	GO:0005923	bicellular tight junction(GO:0005923)
2.3	23.4	GO:0014731	spectrin-associated cytoskeleton(GO:0014731)
7.2	21.6	GO:0044317	rod spherule(GO:0044317)
0.1	17.7	GO:0098852	lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.2	16.0	GO:0019005	SCF ubiquitin ligase complex(GO:0019005)

Showing 1 to 10 of 60 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	117.7	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
1.9	56.0	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
3.9	55.0	GO:0016208	AMP binding(GO:0016208)
0.2	43.7	GO:0004252	serine-type endopeptidase activity(GO:0004252)
3.2	29.2	GO:0031995	insulin-like growth factor II binding(GO:0031995)
8.7	26.2	GO:0004792	thiosulfate sulfurtransferase activity(GO:0004792)
0.8	23.4	GO:0008519	ammonium transmembrane transporter activity(GO:0008519)
1.4	22.0	GO:0004029	aldehyde dehydrogenase (NAD) activity(GO:0004029)
0.5	20.8	GO:0004364	glutathione transferase activity(GO:0004364)
4.8	19.3	GO:0008940	nitrate reductase activity(GO:0008940)

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	151.7	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.9	36.8	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.1	18.0	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.6	16.6	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.3	12.2	PID FOXM1 PATHWAY	FOXM1 transcription factor network
0.3	8.3	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.2	8.2	PID ERBB4 PATHWAY	ErbB4 signaling events
0.1	8.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.2	6.2	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.2	6.1	PID P38 ALPHA BETA PATHWAY	Regulation of p38-alpha and p38-beta

Showing 1 to 10 of 22 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	49.6	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
4.3	43.0	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.5	29.2	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.0	26.2	REACTOME SULFUR AMINO ACID METABOLISM	Genes involved in Sulfur amino acid metabolism
0.1	22.0	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
0.1	18.0	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.9	16.4	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
1.3	15.6	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.6	14.4	REACTOME CGMP EFFECTS	Genes involved in cGMP effects
1.0	13.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 51 entries

Results for Zbtb4

Z-value: 0.84

Motif logo

Transcription factors associated with Zbtb4

Activity-expression correlation:

Activity profile of Zbtb4 motif

Sorted Z-values of Zbtb4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: