ISMARA results: Zbtb33

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb33_Chd2

Z-value: 1.84

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Transcription factors associated with Zbtb33_Chd2

Gene Symbol	Gene ID	Gene Info
Zbtb33 NCBI RGD Ensembl	ENSRNOG00000028899	zinc finger and BTB domain containing 33
Chd2 NCBI RGD Ensembl	ENSRNOG00000012716	chromodomain helicase DNA binding protein 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Chd2	rn6_v1_chr1_-_134867001_134867001	0.33	2.5e-09	Click!
Zbtb33	rn6_v1_chrX_+_124393332_124393332	0.15	8.9e-03	Click!

Activity profile of Zbtb33_Chd2 motif

Sorted Z-values of Zbtb33_Chd2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_69927938 Show fit	83.46	ENSRNOT00000058838	Ncapg NCBI RGD Ensembl Show fit	non-SMC condensin I complex, subunit G
chr5_+_38844488 Show fit	68.86	ENSRNOT00000009545	Mms22l NCBI RGD Ensembl Show fit	MMS22-like, DNA repair protein
chr10_-_19652898 Show fit	65.91	ENSRNOT00000009648	Spdl1 NCBI RGD Ensembl Show fit	spindle apparatus coiled-coil protein 1
chr11_-_54404612 Show fit	49.97	ENSRNOT00000033837	RGD1310335 NCBI RGD Ensembl Show fit	similar to RIKEN cDNA C330027C09
chr2_+_165601007 Show fit	47.27	ENSRNOT00000013931	Smc4 NCBI RGD Ensembl Show fit	structural maintenance of chromosomes 4
chr7_+_140758615 Show fit	47.19	ENSRNOT00000089448	Troap NCBI RGD Ensembl Show fit	trophinin associated protein
chr1_+_279633671 Show fit	41.14	ENSRNOT00000036012 ENSRNOT00000091669	Ccdc172 NCBI RGD Ensembl Show fit	coiled-coil domain containing 172
chr9_-_11027506 Show fit	37.72	ENSRNOT00000071107	Chaf1a NCBI RGD Ensembl Show fit	chromatin assembly factor 1 subunit A
chr3_-_110021149 Show fit	37.08	ENSRNOT00000007808	Fsip1 NCBI RGD Ensembl Show fit	fibrous sheath interacting protein 1
chr1_+_257615088 Show fit	36.88	ENSRNOT00000083183	LOC100911660 NCBI RGD Ensembl Show fit	lymphocyte-specific helicase-like

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb33_Chd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
9.6	125.0	GO:0007076	mitotic chromosome condensation(GO:0007076)
6.9	103.5	GO:0034501	protein localization to kinetochore(GO:0034501)
2.1	72.8	GO:0031297	replication fork processing(GO:0031297)
12.5	62.7	GO:0031508	pericentric heterochromatin assembly(GO:0031508)
9.3	55.6	GO:0060528	secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development(GO:0060528)
1.4	51.1	GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.8	50.0	GO:2000179	positive regulation of neural precursor cell proliferation(GO:2000179)
9.9	39.6	GO:0014835	myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.9	39.5	GO:0010501	RNA secondary structure unwinding(GO:0010501)
1.4	37.7	GO:0034723	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)

Showing 1 to 10 of 196 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
20.6	164.5	GO:0000796	condensin complex(GO:0000796)
1.6	119.9	GO:0022627	cytosolic small ribosomal subunit(GO:0022627)
5.9	83.1	GO:0000940	condensed chromosome outer kinetochore(GO:0000940)
23.0	68.9	GO:0035101	FACT complex(GO:0035101)
2.0	62.7	GO:0005721	pericentric heterochromatin(GO:0005721)
0.7	60.5	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
3.7	55.6	GO:0034709	methylosome(GO:0034709)
0.4	49.3	GO:0005913	cell-cell adherens junction(GO:0005913)
2.0	40.6	GO:0005680	anaphase-promoting complex(GO:0005680)
1.5	40.0	GO:0035145	exon-exon junction complex(GO:0035145)

Showing 1 to 10 of 118 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	107.4	GO:0005524	ATP binding(GO:0005524)
7.3	65.9	GO:0043515	kinetochore binding(GO:0043515)
0.6	59.3	GO:0003697	single-stranded DNA binding(GO:0003697)
2.6	55.6	GO:0008327	methyl-CpG binding(GO:0008327)
2.3	49.3	GO:0098641	cadherin binding involved in cell-cell adhesion(GO:0098641)
0.2	48.2	GO:0003735	structural constituent of ribosome(GO:0003735)
0.6	44.0	GO:0004004	RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
4.9	39.6	GO:0048273	mitogen-activated protein kinase p38 binding(GO:0048273) NFAT protein binding(GO:0051525)
0.3	38.0	GO:0042393	histone binding(GO:0042393)
4.7	37.7	GO:0070087	chromo shadow domain binding(GO:0070087)

Showing 1 to 10 of 143 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	164.1	PID AURORA B PATHWAY	Aurora B signaling
1.3	95.5	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
1.2	83.1	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
2.3	47.8	PID NFKAPPAB ATYPICAL PATHWAY	Atypical NF-kappaB pathway
1.0	34.6	PID BARD1 PATHWAY	BARD1 signaling events
0.7	32.7	PID PLK1 PATHWAY	PLK1 signaling events
0.7	30.4	PID NEPHRIN NEPH1 PATHWAY	Nephrin/Neph1 signaling in the kidney podocyte
0.3	21.5	PID CMYB PATHWAY	C-MYB transcription factor network
0.5	19.9	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.2	16.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 32 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	136.7	REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX	Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
2.1	117.2	REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX	Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.8	70.7	REACTOME CHROMOSOME MAINTENANCE	Genes involved in Chromosome Maintenance
1.0	70.1	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
1.4	68.5	REACTOME METABOLISM OF NON CODING RNA	Genes involved in Metabolism of non-coding RNA
2.5	40.6	REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE	Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
2.6	39.6	REACTOME P38MAPK EVENTS	Genes involved in p38MAPK events
1.5	25.2	REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER	Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
1.1	24.8	REACTOME SIGNALING BY HIPPO	Genes involved in Signaling by Hippo
0.1	24.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation

Showing 1 to 10 of 57 entries

Results for Zbtb33_Chd2

Z-value: 1.84

Motif logo

Transcription factors associated with Zbtb33_Chd2

Activity-expression correlation:

Activity profile of Zbtb33_Chd2 motif

Sorted Z-values of Zbtb33_Chd2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb33_Chd2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: