ISMARA results: Zbtb3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Zbtb3

Z-value: 1.07

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Transcription factors associated with Zbtb3

Gene Symbol	Gene ID	Gene Info
Zbtb3 NCBI RGD Ensembl	ENSRNOG00000019461	zinc finger and BTB domain containing 3

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Zbtb3	rn6_v1_chr1_+_224998172_224998172	0.25	5.9e-06	Click!

Activity profile of Zbtb3 motif

Sorted Z-values of Zbtb3 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr16_-_84939323 Show fit	107.43	ENSRNOT00000022742	Myo16 NCBI RGD Ensembl Show fit	myosin XVI
chr7_-_113937941 Show fit	59.93	ENSRNOT00000012408	Kcnk9 NCBI RGD Ensembl Show fit	potassium two pore domain channel subfamily K member 9
chrX_+_65040934 Show fit	48.69	ENSRNOT00000044006	Zc3h12b NCBI RGD Ensembl Show fit	zinc finger CCCH-type containing 12B
chr1_-_188713270 Show fit	48.52	ENSRNOT00000082192 ENSRNOT00000065892	Gprc5b NCBI RGD Ensembl Show fit	G protein-coupled receptor, class C, group 5, member B
chr3_-_176666282 Show fit	48.28	ENSRNOT00000016947	Eef1a2 NCBI RGD Ensembl Show fit	eukaryotic translation elongation factor 1 alpha 2
chr16_+_26906716 Show fit	47.42	ENSRNOT00000064297	Cpe NCBI RGD Ensembl Show fit	carboxypeptidase E
chrX_+_65040775 Show fit	45.61	ENSRNOT00000081354	Zc3h12b NCBI RGD Ensembl Show fit	zinc finger CCCH-type containing 12B
chr2_+_18392142 Show fit	44.82	ENSRNOT00000043196	Hapln1 NCBI RGD Ensembl Show fit	hyaluronan and proteoglycan link protein 1
chr20_-_13142856 Show fit	41.91	ENSRNOT00000001743	S100b NCBI RGD Ensembl Show fit	S100 calcium binding protein B
chr2_-_26699333 Show fit	41.39	ENSRNOT00000024459	Sv2c NCBI RGD Ensembl Show fit	synaptic vesicle glycoprotein 2c

Showing 1 to 10 of 153 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	107.4	GO:2000134	negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
5.6	67.0	GO:1900028	negative regulation of ruffle assembly(GO:1900028)
3.7	48.5	GO:0060907	positive regulation of macrophage cytokine production(GO:0060907)
0.7	48.3	GO:0006414	translational elongation(GO:0006414)
9.5	47.4	GO:2000173	insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
0.1	42.4	GO:0001501	skeletal system development(GO:0001501)
6.0	41.9	GO:2001015	negative regulation of skeletal muscle cell differentiation(GO:2001015)
0.3	41.9	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2	41.4	GO:0006836	neurotransmitter transport(GO:0006836)
0.6	37.2	GO:0065002	intracellular protein transmembrane transport(GO:0065002)

Showing 1 to 10 of 88 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	107.4	GO:0016459	myosin complex(GO:0016459)
4.7	75.0	GO:0031045	dense core granule(GO:0031045)
0.5	67.0	GO:0043195	terminal bouton(GO:0043195)
0.5	59.9	GO:0008021	synaptic vesicle(GO:0008021)
0.1	54.9	GO:0005887	integral component of plasma membrane(GO:0005887)
0.1	52.3	GO:0009986	cell surface(GO:0009986)
16.1	48.3	GO:0005853	eukaryotic translation elongation factor 1 complex(GO:0005853)
0.2	41.9	GO:0001726	ruffle(GO:0001726)
0.5	41.4	GO:0099501	synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
1.2	37.2	GO:0098827	endoplasmic reticulum subcompartment(GO:0098827)

Showing 1 to 10 of 49 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	107.4	GO:0003774	motor activity(GO:0003774)
6.7	67.0	GO:0000774	adenyl-nucleotide exchange factor activity(GO:0000774)
0.6	59.9	GO:0005249	voltage-gated potassium channel activity(GO:0005249)
2.2	48.3	GO:0003746	translation elongation factor activity(GO:0003746)
4.0	47.4	GO:0050897	cobalt ion binding(GO:0050897)
1.6	44.8	GO:0005540	hyaluronic acid binding(GO:0005540)
0.6	43.9	GO:0030295	protein kinase activator activity(GO:0030295)
4.7	41.9	GO:0050786	RAGE receptor binding(GO:0050786)
0.0	37.7	GO:0046872	metal ion binding(GO:0046872)
11.7	35.2	GO:0047237	glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)

Showing 1 to 10 of 75 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	47.4	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events
0.1	35.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.8	34.1	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.3	33.7	ST INTEGRIN SIGNALING PATHWAY	Integrin Signaling Pathway
0.7	32.8	PID ATR PATHWAY	ATR signaling pathway
1.2	25.0	PID ARF6 DOWNSTREAM PATHWAY	Arf6 downstream pathway
0.4	18.1	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
0.7	17.9	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.5	8.9	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.1	8.3	PID IL12 2PATHWAY	IL12-mediated signaling events

Showing 1 to 10 of 19 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.6	59.9	REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS	Genes involved in Tandem pore domain potassium channels
3.0	41.9	REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING	Genes involved in Advanced glycosylation endproduct receptor signaling
1.4	35.6	REACTOME INSULIN SYNTHESIS AND PROCESSING	Genes involved in Insulin Synthesis and Processing
0.8	29.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.4	27.5	REACTOME NRAGE SIGNALS DEATH THROUGH JNK	Genes involved in NRAGE signals death through JNK
1.6	24.4	REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS	Genes involved in Proteolytic cleavage of SNARE complex proteins
0.2	21.1	REACTOME GLUCOSE METABOLISM	Genes involved in Glucose metabolism
0.4	18.1	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
0.3	16.7	REACTOME ION TRANSPORT BY P TYPE ATPASES	Genes involved in Ion transport by P-type ATPases
0.1	15.6	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides

Showing 1 to 10 of 26 entries

Results for Zbtb3

Z-value: 1.07

Motif logo

Transcription factors associated with Zbtb3

Activity-expression correlation:

Activity profile of Zbtb3 motif

Sorted Z-values of Zbtb3 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Zbtb3

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: