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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Zbtb14
Z-value: 1.26
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Transcription factors associated with Zbtb14
| Gene Symbol | Gene ID | Gene Info |
|---|
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Zfp161 | rn6_v1_chr9_+_117737611_117737611 | 0.24 | 1.0e-05 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_14056169 Show fit | 61.11 |
ENSRNOT00000017833
|
synaptogyrin 3 |
|
| chr13_-_49522415 Show fit | 57.84 |
ENSRNOT00000060871
ENSRNOT00000051512 |
neurofascin |
|
| chr8_-_116965396 Show fit | 56.89 |
ENSRNOT00000042528
|
bassoon (presynaptic cytomatrix protein) |
|
| chr10_-_92008082 Show fit | 50.31 |
ENSRNOT00000006361
|
N-ethylmaleimide sensitive factor, vesicle fusing ATPase |
|
| chr4_+_49941304 Show fit | 49.90 |
ENSRNOT00000008719
|
protein tyrosine phosphatase, receptor type Z1 |
|
| chr2_-_119537837 Show fit | 46.51 |
ENSRNOT00000015200
|
peroxisomal biogenesis factor 5-like |
|
| chr3_-_2534375 Show fit | 45.98 |
ENSRNOT00000037725
|
glutamate ionotropic receptor NMDA type subunit 1 |
|
| chr19_+_41482728 Show fit | 44.95 |
ENSRNOT00000022943
|
calbindin 2 |
|
| chr9_+_38297322 Show fit | 44.66 |
ENSRNOT00000078157
ENSRNOT00000088824 |
BEN domain containing 6 |
|
| chr8_+_39305128 Show fit | 43.40 |
ENSRNOT00000008285
|
fasciculation and elongation protein zeta 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Zbtb14
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 10.5 | 105.4 | GO:1902474 | positive regulation of protein localization to synapse(GO:1902474) |
| 25.1 | 75.2 | GO:1900673 | olefin metabolic process(GO:1900673) |
| 12.6 | 63.1 | GO:0031630 | regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
| 2.2 | 63.0 | GO:1903831 | acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145) |
| 9.6 | 57.8 | GO:0071205 | protein localization to juxtaparanode region of axon(GO:0071205) |
| 9.5 | 57.0 | GO:0098928 | presynaptic signal transduction(GO:0098928) presynapse to nucleus signaling pathway(GO:0099526) |
| 1.3 | 56.6 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 1.6 | 55.6 | GO:0045956 | positive regulation of calcium ion-dependent exocytosis(GO:0045956) |
| 1.1 | 51.2 | GO:0021762 | substantia nigra development(GO:0021762) |
| 12.6 | 50.3 | GO:0035494 | SNARE complex disassembly(GO:0035494) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 199.4 | GO:0016021 | integral component of membrane(GO:0016021) |
| 1.1 | 157.5 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 1.3 | 99.9 | GO:0043198 | dendritic shaft(GO:0043198) |
| 1.1 | 91.8 | GO:0099501 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 18.9 | 75.8 | GO:0045298 | tubulin complex(GO:0045298) |
| 18.8 | 75.2 | GO:0044307 | dendritic branch(GO:0044307) |
| 2.3 | 72.5 | GO:0097440 | apical dendrite(GO:0097440) |
| 19.0 | 56.9 | GO:1990257 | piccolo-bassoon transport vesicle(GO:1990257) |
| 0.4 | 56.1 | GO:0030133 | transport vesicle(GO:0030133) |
| 11.0 | 55.1 | GO:0097454 | Schwann cell microvillus(GO:0097454) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 19.0 | 114.0 | GO:0099529 | neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) |
| 1.5 | 92.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 18.9 | 75.8 | GO:0099609 | microtubule lateral binding(GO:0099609) |
| 0.5 | 65.8 | GO:0005267 | potassium channel activity(GO:0005267) |
| 3.4 | 60.8 | GO:0043008 | ATP-dependent protein binding(GO:0043008) |
| 8.5 | 59.5 | GO:0045503 | dynein light chain binding(GO:0045503) |
| 6.4 | 57.8 | GO:0086080 | protein binding involved in heterotypic cell-cell adhesion(GO:0086080) |
| 4.1 | 56.7 | GO:0030550 | acetylcholine receptor inhibitor activity(GO:0030550) |
| 1.2 | 55.2 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 1.6 | 53.9 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.8 | 75.8 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.2 | 44.9 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.1 | 44.2 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.9 | 33.7 | PID REELIN PATHWAY | Reelin signaling pathway |
| 1.3 | 33.5 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.4 | 32.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 1.0 | 32.5 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 2.1 | 32.2 | PID S1P S1P4 PATHWAY | S1P4 pathway |
| 0.5 | 30.4 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.6 | 30.0 | PID P75 NTR PATHWAY | p75(NTR)-mediated signaling |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.7 | 173.9 | REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION | Genes involved in Unblocking of NMDA receptor, glutamate binding and activation |
| 3.2 | 93.8 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 4.8 | 66.5 | REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Norepinephrine Neurotransmitter Release Cycle |
| 2.5 | 50.4 | REACTOME ACTIVATION OF NMDA RECEPTOR UPON GLUTAMATE BINDING AND POSTSYNAPTIC EVENTS | Genes involved in Activation of NMDA receptor upon glutamate binding and postsynaptic events |
| 3.5 | 49.3 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 1.6 | 47.3 | REACTOME G PROTEIN ACTIVATION | Genes involved in G-protein activation |
| 0.3 | 45.7 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 2.4 | 40.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 1.5 | 33.2 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 2.2 | 32.9 | REACTOME GABA SYNTHESIS RELEASE REUPTAKE AND DEGRADATION | Genes involved in GABA synthesis, release, reuptake and degradation |