ISMARA results: Yy1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Yy1_Yy2

Z-value: 2.49

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Transcription factors associated with Yy1_Yy2

Gene Symbol	Gene ID	Gene Info
Yy1 NCBI RGD Ensembl	ENSRNOG00000004339	YY1 transcription factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Yy1	rn6_v1_chr6_+_132702448_132702448	-0.26	3.6e-06	Click!

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr10_+_13836128 Show fit	27.23	ENSRNOT00000012720	Pgp NCBI RGD Ensembl Show fit	phosphoglycolate phosphatase
chr1_-_169321075 Show fit	23.58	ENSRNOT00000055216	RGD1562433 NCBI RGD Ensembl Show fit	similar to ubiquilin 1 isoform 2
chr1_+_89408935 Show fit	22.86	ENSRNOT00000075068	LOC100909893 NCBI RGD Ensembl Show fit	protein FAM187B-like
chr1_-_88066101 Show fit	22.72	ENSRNOT00000079473 ENSRNOT00000027893	Ryr1 NCBI RGD Ensembl Show fit	ryanodine receptor 1
chr10_+_53781239 Show fit	22.15	ENSRNOT00000082871	Myh2 NCBI RGD Ensembl Show fit	myosin heavy chain 2
chr10_-_13168217 Show fit	19.90	ENSRNOT00000087768	Elob NCBI RGD Ensembl Show fit	elongin B
chr16_+_90613870 Show fit	18.52	ENSRNOT00000079334	Shcbp1 NCBI RGD Ensembl Show fit	SHC binding and spindle associated 1
chr4_+_153774486 Show fit	18.02	ENSRNOT00000074096	Tuba8 NCBI RGD Ensembl Show fit	tubulin, alpha 8
chr8_+_116708027 Show fit	17.73	ENSRNOT00000047309	Actl11 NCBI RGD Ensembl Show fit	actin-like 11
chr9_+_24095751 Show fit	17.45	ENSRNOT00000018177	Pgk2 NCBI RGD Ensembl Show fit	phosphoglycerate kinase 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	2013.2	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.4	204.0	GO:0006412	translation(GO:0006412)
2.4	63.9	GO:0006335	DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
3.9	62.3	GO:0031034	myosin filament assembly(GO:0031034)
1.3	59.6	GO:0032543	mitochondrial translation(GO:0032543)
2.0	49.3	GO:0015986	energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.7	46.6	GO:0006342	chromatin silencing(GO:0006342)
1.2	44.9	GO:0003009	skeletal muscle contraction(GO:0003009)
2.7	42.7	GO:1901663	ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
2.1	40.3	GO:0035404	histone-serine phosphorylation(GO:0035404)

Showing 1 to 10 of 851 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.0	187.1	GO:0000786	nucleosome(GO:0000786)
0.9	120.0	GO:0005840	ribosome(GO:0005840)
2.3	119.7	GO:0005747	mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
1.9	110.8	GO:0000315	organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.9	100.7	GO:0001669	acrosomal vesicle(GO:0001669)
0.7	96.8	GO:0031674	I band(GO:0031674)
3.2	93.5	GO:0005763	organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
1.0	89.0	GO:0022625	cytosolic large ribosomal subunit(GO:0022625)
3.2	76.6	GO:0001673	male germ cell nucleus(GO:0001673)
1.3	67.9	GO:0000777	condensed chromosome kinetochore(GO:0000777)

Showing 1 to 10 of 337 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.6	2013.2	GO:0004984	olfactory receptor activity(GO:0004984)
1.3	347.8	GO:0003735	structural constituent of ribosome(GO:0003735)
1.0	182.8	GO:0042393	histone binding(GO:0042393)
0.7	80.4	GO:0004222	metalloendopeptidase activity(GO:0004222)
2.5	70.1	GO:0003954	NADH dehydrogenase activity(GO:0003954)
1.2	69.5	GO:0003743	translation initiation factor activity(GO:0003743)
0.0	66.8	GO:0003677	DNA binding(GO:0003677)
2.3	62.1	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
1.8	60.5	GO:0061631	ubiquitin conjugating enzyme activity(GO:0061631)
3.7	54.9	GO:0004679	AMP-activated protein kinase activity(GO:0004679)

Showing 1 to 10 of 502 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	48.9	PID AURORA B PATHWAY	Aurora B signaling
2.6	33.9	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression
0.9	32.7	PID ATR PATHWAY	ATR signaling pathway
0.7	32.0	PID PLK1 PATHWAY	PLK1 signaling events
0.6	30.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.5	24.0	PID HDAC CLASSI PATHWAY	Signaling events mediated by HDAC Class I
0.5	24.0	PID NFAT TFPATHWAY	Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4	23.2	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.7	20.6	PID IL27 PATHWAY	IL27-mediated signaling events
0.3	19.6	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation

Showing 1 to 10 of 53 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	114.1	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.8	112.8	REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS	Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
1.1	108.5	REACTOME PEPTIDE CHAIN ELONGATION	Genes involved in Peptide chain elongation
1.8	83.4	REACTOME MITOCHONDRIAL PROTEIN IMPORT	Genes involved in Mitochondrial Protein Import
2.0	83.3	REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE	Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
1.5	78.3	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
1.9	74.0	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.7	61.7	REACTOME GLUCONEOGENESIS	Genes involved in Gluconeogenesis
3.8	60.6	REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING	Genes involved in Formation of ATP by chemiosmotic coupling
0.7	49.8	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 123 entries

Results for Yy1_Yy2

Z-value: 2.49

Motif logo

Transcription factors associated with Yy1_Yy2

Activity-expression correlation:

Activity profile of Yy1_Yy2 motif

Sorted Z-values of Yy1_Yy2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Yy1_Yy2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: