ISMARA results: Xbp1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Xbp1_Creb3l1

Z-value: 1.16

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Transcription factors associated with Xbp1_Creb3l1

Gene Symbol	Gene ID	Gene Info
Xbp1 NCBI RGD Ensembl	ENSRNOG00000010298	X-box binding protein 1
Creb3l1 NCBI RGD Ensembl	ENSRNOG00000005413	cAMP responsive element binding protein 3-like 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Creb3l1	rn6_v1_chr3_-_80933283_80933283	0.56	5.8e-28	Click!
Xbp1	rn6_v1_chr14_+_85753760_85753760	0.42	2.6e-15	Click!

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr1_-_101086198 Show fit	52.35	ENSRNOT00000027917	Rcn3 NCBI RGD Ensembl Show fit	reticulocalbin 3
chr1_-_101085884 Show fit	49.81	ENSRNOT00000085352	Rcn3 NCBI RGD Ensembl Show fit	reticulocalbin 3
chr2_+_227455722 Show fit	46.48	ENSRNOT00000064809	Sec24d NCBI RGD Ensembl Show fit	SEC24 homolog D, COPII coat complex component
chr18_+_52423883 Show fit	32.44	ENSRNOT00000022017	Prrc1 NCBI RGD Ensembl Show fit	proline-rich coiled-coil 1
chr7_+_120749752 Show fit	31.00	ENSRNOT00000087888	Kdelr3 NCBI RGD Ensembl Show fit	KDEL endoplasmic reticulum protein retention receptor 3
chr4_+_56625561 Show fit	29.46	ENSRNOT00000008356 ENSRNOT00000090808 ENSRNOT00000008972	Calu NCBI RGD Ensembl Show fit	calumenin
chr5_-_173081839 Show fit	29.32	ENSRNOT00000066880	Mmp23 NCBI RGD Ensembl Show fit	matrix metallopeptidase 23
chr18_-_47513030 Show fit	28.00	ENSRNOT00000083881 ENSRNOT00000074226	Lox NCBI RGD Ensembl Show fit	lysyl oxidase
chr17_+_26925828 Show fit	24.66	ENSRNOT00000018310	Txndc5 NCBI RGD Ensembl Show fit	thioredoxin domain containing 5
chr13_+_80125391 Show fit	21.64	ENSRNOT00000044190	Mir199a2 NCBI RGD Ensembl Show fit	microRNA 199a-2

Showing 1 to 10 of 159 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	85.3	GO:0006888	ER to Golgi vesicle-mediated transport(GO:0006888)
7.0	48.9	GO:0006621	protein retention in ER lumen(GO:0006621)
0.6	37.6	GO:0045454	cell redox homeostasis(GO:0045454)
1.8	29.5	GO:0014012	peripheral nervous system axon regeneration(GO:0014012)
2.8	28.0	GO:0048251	elastic fiber assembly(GO:0048251)
0.1	25.8	GO:0001649	osteoblast differentiation(GO:0001649)
7.6	22.8	GO:0031204	posttranslational protein targeting to membrane, translocation(GO:0031204)
0.0	22.0	GO:0006508	proteolysis(GO:0006508)
0.2	21.2	GO:0008203	cholesterol metabolic process(GO:0008203)
5.9	17.8	GO:0002353	kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353) activation of plasma proteins involved in acute inflammatory response(GO:0002541)

Showing 1 to 10 of 77 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	148.6	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
3.9	55.0	GO:0030127	COPII vesicle coat(GO:0030127)
0.5	37.6	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
1.5	30.6	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
7.4	29.5	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)
0.4	28.0	GO:0005581	collagen trimer(GO:0005581)
1.6	27.4	GO:0008250	oligosaccharyltransferase complex(GO:0008250)
0.7	21.2	GO:0034364	high-density lipoprotein particle(GO:0034364)
0.5	21.1	GO:0005801	cis-Golgi network(GO:0005801)
0.1	21.1	GO:0001726	ruffle(GO:0001726)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	157.6	GO:0005509	calcium ion binding(GO:0005509)
9.8	48.9	GO:0046923	ER retention sequence binding(GO:0046923)
1.9	38.9	GO:0003756	protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.0	33.6	GO:0008270	zinc ion binding(GO:0008270)
0.2	29.5	GO:0004222	metalloendopeptidase activity(GO:0004222)
5.6	28.0	GO:0004720	protein-lysine 6-oxidase activity(GO:0004720)
2.0	27.4	GO:0004579	oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2	22.9	GO:0008565	protein transporter activity(GO:0008565)
1.2	19.8	GO:0035497	cAMP response element binding(GO:0035497)
0.1	19.8	GO:0017124	SH3 domain binding(GO:0017124)

Showing 1 to 10 of 67 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	57.0	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3	14.0	PID HIF2PATHWAY	HIF-2-alpha transcription factor network
0.5	13.9	PID ARF 3PATHWAY	Arf1 pathway
0.2	13.1	PID PLK1 PATHWAY	PLK1 signaling events
0.4	11.5	PID NECTIN PATHWAY	Nectin adhesion pathway
0.1	5.7	PID CD40 PATHWAY	CD40/CD40L signaling
0.1	4.5	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.0	4.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.4	4.2	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.0	3.8	PID CMYB PATHWAY	C-MYB transcription factor network

Showing 1 to 10 of 18 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	70.9	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
0.5	59.5	REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE	Genes involved in SRP-dependent cotranslational protein targeting to membrane
2.9	51.7	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.0	24.7	REACTOME LYSOSOME VESICLE BIOGENESIS	Genes involved in Lysosome Vesicle Biogenesis
0.3	18.8	REACTOME ASPARAGINE N LINKED GLYCOSYLATION	Genes involved in Asparagine N-linked glycosylation
0.8	17.8	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.2	16.4	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	16.0	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.4	15.4	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.0	12.8	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules

Showing 1 to 10 of 30 entries

Results for Xbp1_Creb3l1

Z-value: 1.16

Motif logo

Transcription factors associated with Xbp1_Creb3l1

Activity-expression correlation:

Activity profile of Xbp1_Creb3l1 motif

Sorted Z-values of Xbp1_Creb3l1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Xbp1_Creb3l1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: