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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Wrnip1_Mta3_Rcor1
Z-value: 4.47
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Transcription factors associated with Wrnip1_Mta3_Rcor1
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSRNOG00000017040 | Werner helicase interacting protein 1 | |
| ENSRNOG00000004685 | metastasis associated 1 family, member 3 | |
| ENSRNOG00000008067 | REST corepressor 1 | |
| ENSRNOG00000049783 | REST corepressor 1 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Wrnip1 | rn6_v1_chr17_-_32953641_32953641 | 0.53 | 2.9e-24 | Click! |
| Rcor1 | rn6_v1_chr6_+_135513650_135513650 | -0.33 | 1.4e-09 | Click! |
| Mta3 | rn6_v1_chr6_+_6908684_6908684 | -0.14 | 1.1e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr17_-_10766253 Show fit | 168.14 |
ENSRNOT00000000117
|
complexin 2 |
|
| chr6_-_99870024 Show fit | 164.80 |
ENSRNOT00000010043
|
RAB15, member RAS oncogene family |
|
| chr20_+_10123651 Show fit | 148.72 |
ENSRNOT00000001559
|
phosphodiesterase 9A |
|
| chr9_-_94601852 Show fit | 148.62 |
ENSRNOT00000022485
|
neuronal guanine nucleotide exchange factor |
|
| chr3_-_176666282 Show fit | 147.06 |
ENSRNOT00000016947
|
eukaryotic translation elongation factor 1 alpha 2 |
|
| chr6_+_105364668 Show fit | 143.84 |
ENSRNOT00000009513
ENSRNOT00000087090 |
tetratricopeptide repeat domain 9 |
|
| chr3_+_6773813 Show fit | 130.81 |
ENSRNOT00000065953
ENSRNOT00000013443 |
olfactomedin 1 |
|
| chr1_+_101682172 Show fit | 128.22 |
ENSRNOT00000028540
|
carbonic anhydrase 11 |
|
| chr13_-_52197205 Show fit | 126.27 |
ENSRNOT00000009712
|
shisa family member 4 |
|
| chr13_+_104816371 Show fit | 120.42 |
ENSRNOT00000086497
|
|
Network of associatons between targets according to the STRING database.
First level regulatory network of Wrnip1_Mta3_Rcor1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.8 | 1159.4 | GO:0007416 | synapse assembly(GO:0007416) |
| 11.8 | 967.2 | GO:0007269 | neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643) |
| 0.7 | 935.7 | GO:0007606 | sensory perception of chemical stimulus(GO:0007606) |
| 7.8 | 653.9 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 14.7 | 587.1 | GO:0036465 | synaptic vesicle recycling(GO:0036465) |
| 36.5 | 475.1 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 16.1 | 465.9 | GO:0007215 | glutamate receptor signaling pathway(GO:0007215) |
| 19.6 | 450.0 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 17.3 | 414.9 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 20.9 | 376.3 | GO:0071625 | vocalization behavior(GO:0071625) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 6611.6 | GO:0016021 | integral component of membrane(GO:0016021) |
| 13.4 | 2257.4 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 11.2 | 2023.3 | GO:0043209 | myelin sheath(GO:0043209) |
| 8.5 | 1870.3 | GO:0098794 | postsynapse(GO:0098794) |
| 6.4 | 1738.7 | GO:0045202 | synapse(GO:0045202) |
| 5.7 | 1580.3 | GO:0043025 | neuronal cell body(GO:0043025) |
| 14.8 | 1301.6 | GO:0034705 | potassium channel complex(GO:0034705) |
| 5.3 | 1057.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 22.8 | 980.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 10.7 | 935.2 | GO:0005604 | basement membrane(GO:0005604) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 2512.8 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.7 | 1015.3 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 4.7 | 980.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 27.2 | 923.7 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 4.0 | 883.0 | GO:0015631 | tubulin binding(GO:0015631) |
| 13.9 | 791.0 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 3.4 | 718.8 | GO:0003924 | GTPase activity(GO:0003924) |
| 8.2 | 711.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 26.9 | 698.3 | GO:0004890 | GABA-A receptor activity(GO:0004890) |
| 13.4 | 656.7 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 1468.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 7.6 | 1148.4 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 12.4 | 620.1 | NABA BASEMENT MEMBRANES | Genes encoding structural components of basement membranes |
| 1.9 | 426.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 11.2 | 402.1 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 10.1 | 392.3 | PID RAS PATHWAY | Regulation of Ras family activation |
| 9.9 | 356.9 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 6.9 | 343.5 | PID BMP PATHWAY | BMP receptor signaling |
| 4.6 | 304.1 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 10.5 | 303.5 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.4 | 753.7 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 5.7 | 735.2 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 11.7 | 711.7 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 20.2 | 705.9 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 17.5 | 701.0 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 17.8 | 692.8 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 17.8 | 658.0 | REACTOME INWARDLY RECTIFYING K CHANNELS | Genes involved in Inwardly rectifying K+ channels |
| 35.3 | 599.8 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 6.6 | 584.0 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 15.1 | 572.3 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |