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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Twist1

Z-value: 0.45

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Transcription factors associated with Twist1

Gene Symbol Gene ID Gene Info
Twist1
ENSRNOG00000011101 twist family bHLH transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Twist1rn6_v1_chr6_+_53401109_53401109-0.156.4e-03Click!

Activity profile of Twist1 motif

Sorted Z-values of Twist1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_69268336 29.20 ENSRNOT00000018042
Prss3b
protease, serine, 3B
chr19_-_37907714 15.90 ENSRNOT00000026361
Ctrl
chymotrypsin-like
chr4_-_69196430 13.55 ENSRNOT00000017673
LOC312273
Trypsin V-A
chr20_-_5123073 11.29 ENSRNOT00000001126
Apom
apolipoprotein M
chr1_+_100470722 10.89 ENSRNOT00000086917
Aspdh
aspartate dehydrogenase domain containing
chr13_+_89826254 7.86 ENSRNOT00000006141
F11r
F11 receptor
chr3_+_5624506 7.54 ENSRNOT00000036995
Adamtsl2
ADAMTS-like 2
chr3_-_170955399 7.19 ENSRNOT00000084990
Bmp7
bone morphogenetic protein 7
chr1_+_263448633 5.33 ENSRNOT00000064510
Entpd7
ectonucleoside triphosphate diphosphohydrolase 7
chr10_+_91187593 4.88 ENSRNOT00000004163
Acbd4
acyl-CoA binding domain containing 4
chr10_-_90999506 4.80 ENSRNOT00000034401
Gfap
glial fibrillary acidic protein
chr12_+_17416327 4.42 ENSRNOT00000089590
ENSRNOT00000092186
Adap1
ArfGAP with dual PH domains 1
chr5_-_169212170 4.37 ENSRNOT00000013385
Tas1r1
taste 1 receptor member 1
chr10_+_58776792 4.37 ENSRNOT00000019574
Txndc17
thioredoxin domain containing 17
chr1_+_80383050 4.07 ENSRNOT00000023451
Exoc3l2
exocyst complex component 3-like 2
chr15_-_33428942 4.03 ENSRNOT00000019618
ENSRNOT00000092160
Slc7a8
solute carrier family 7 member 8
chr1_-_221431713 4.02 ENSRNOT00000028485
Tm7sf2
transmembrane 7 superfamily member 2
chr19_+_58823814 3.89 ENSRNOT00000027058
ENSRNOT00000088626
Kcnk1
potassium two pore domain channel subfamily K member 1
chr1_-_32272476 3.84 ENSRNOT00000022683
Tert
telomerase reverse transcriptase
chr9_+_27343853 3.83 ENSRNOT00000072794
Tmem14a
transmembrane protein 14A
chr20_-_35449280 3.62 ENSRNOT00000057422
Man1a1
mannosidase, alpha, class 1A, member 1
chr19_+_50045020 3.49 ENSRNOT00000090165
Plcg2
phospholipase C, gamma 2
chr8_-_48672732 3.07 ENSRNOT00000079275
Hmbs
hydroxymethylbilane synthase
chr3_+_35271786 3.00 ENSRNOT00000065989
Lypd6b
LY6/PLAUR domain containing 6B
chr10_+_15088935 2.98 ENSRNOT00000030273
Gng13
G protein subunit gamma 13
chr10_+_13000090 2.63 ENSRNOT00000004845
Cldn6
claudin 6
chr3_-_51297852 2.61 ENSRNOT00000001607
Cobll1
cordon-bleu WH2 repeat protein-like 1
chr1_+_81474553 2.50 ENSRNOT00000083493
Phldb3
pleckstrin homology-like domain, family B, member 3
chr20_+_14101659 2.20 ENSRNOT00000072696
Gucd1
guanylyl cyclase domain containing 1
chr11_+_68198709 2.14 ENSRNOT00000003048
Dirc2
disrupted in renal carcinoma 2
chr1_+_101214593 1.82 ENSRNOT00000028086
Tead2
TEA domain transcription factor 2
chr9_-_17827032 1.81 ENSRNOT00000026929
Slc35b2
solute carrier family 35 member B2
chrX_-_157286936 1.59 ENSRNOT00000078100
Atp2b3
ATPase plasma membrane Ca2+ transporting 3
chr2_-_186245342 1.44 ENSRNOT00000057062
ENSRNOT00000022292
Dclk2
doublecortin-like kinase 2
chr12_-_38691075 1.43 ENSRNOT00000084192
Bcl7a
BCL tumor suppressor 7A
chr1_+_127802978 1.37 ENSRNOT00000055877
Adamts17
ADAM metallopeptidase with thrombospondin type 1 motif, 17
chr1_-_67134827 1.36 ENSRNOT00000045214
Vom1r45
vomeronasal 1 receptor 45
chr20_+_3830164 1.31 ENSRNOT00000045533
ENSRNOT00000084117
Col11a2
collagen type XI alpha 2 chain
chr2_-_186245163 1.24 ENSRNOT00000089339
Dclk2
doublecortin-like kinase 2
chr7_-_97759852 1.14 ENSRNOT00000007484
Derl1
derlin 1
chr5_+_62071346 1.14 ENSRNOT00000012478
Anp32b
acidic nuclear phosphoprotein 32 family member B
chr4_+_140703619 1.09 ENSRNOT00000009563
Bhlhe40
basic helix-loop-helix family, member e40
chrX_+_33599671 1.09 ENSRNOT00000006843
Txlng
taxilin gamma
chr18_-_63488027 1.09 ENSRNOT00000023763
Ptpn2
protein tyrosine phosphatase, non-receptor type 2
chr8_-_55171718 0.93 ENSRNOT00000080736
LOC689959
hypothetical protein LOC689959
chr7_-_12274803 0.78 ENSRNOT00000049146
Apc2
APC2, WNT signaling pathway regulator
chr19_+_55246926 0.63 ENSRNOT00000017358
Il17c
interleukin 17C
chr3_-_130114770 0.60 ENSRNOT00000010638
Jag1
jagged 1
chr15_-_3435888 0.51 ENSRNOT00000016709
Adk
adenosine kinase
chr5_+_39251337 0.45 ENSRNOT00000010073
Ndufaf4
NADH:ubiquinone oxidoreductase complex assembly factor 4
chr1_-_242152834 0.43 ENSRNOT00000071614
ENSRNOT00000020412
Fxn
frataxin
chr1_-_89309379 0.43 ENSRNOT00000028533
Ffar1
free fatty acid receptor 1
chr2_-_30791221 0.41 ENSRNOT00000082846
Ccnb1
cyclin B1
chr20_+_3830376 0.31 ENSRNOT00000085547
Col11a2
collagen type XI alpha 2 chain
chr10_+_75032365 0.25 ENSRNOT00000010448
Supt4h1
SPT4 homolog, DSIF elongation factor subunit
chrX_+_159513800 0.23 ENSRNOT00000065636
Htatsf1
HIV-1 Tat specific factor 1
chr4_-_184096806 0.23 ENSRNOT00000055433
LOC100362344
mKIAA1238 protein-like
chr10_+_87774552 0.21 ENSRNOT00000044342
Krtap9-1
keratin associated protein 9-1
chr20_-_2103864 0.20 ENSRNOT00000001014
Rnf39
ring finger protein 39
chr18_-_29340403 0.09 ENSRNOT00000025157
Hbegf
heparin-binding EGF-like growth factor

Network of associatons between targets according to the STRING database.

First level regulatory network of Twist1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445)
3.6 10.9 GO:0006742 NADP catabolic process(GO:0006742)
2.4 7.2 GO:0072134 nephrogenic mesenchyme morphogenesis(GO:0072134)
1.3 3.8 GO:1900368 regulation of RNA interference(GO:1900368)
0.9 7.5 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.8 4.8 GO:1904714 positive regulation of Schwann cell proliferation(GO:0010625) regulation of chaperone-mediated autophagy(GO:1904714)
0.7 4.4 GO:0050917 sensory perception of umami taste(GO:0050917)
0.6 3.9 GO:0060075 regulation of resting membrane potential(GO:0060075)
0.5 3.1 GO:0018065 protein-cofactor linkage(GO:0018065)
0.4 7.9 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.4 1.1 GO:1903972 regulation of interleukin-6-mediated signaling pathway(GO:0070103) regulation of prolactin signaling pathway(GO:1902211) regulation of interleukin-4-mediated signaling pathway(GO:1902214) regulation of macrophage colony-stimulating factor signaling pathway(GO:1902226) regulation of response to macrophage colony-stimulating factor(GO:1903969) regulation of cellular response to macrophage colony-stimulating factor stimulus(GO:1903972)
0.3 3.5 GO:0032959 inositol trisphosphate biosynthetic process(GO:0032959)
0.3 4.0 GO:0015695 organic cation transport(GO:0015695)
0.3 1.8 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
0.3 1.6 GO:0060023 soft palate development(GO:0060023)
0.3 42.7 GO:0007586 digestion(GO:0007586)
0.2 1.6 GO:1990034 calcium ion export from cell(GO:1990034)
0.2 0.6 GO:0061443 endocardial cushion cell differentiation(GO:0061443)
0.2 2.6 GO:0051639 actin filament network formation(GO:0051639)
0.2 3.6 GO:0006491 N-glycan processing(GO:0006491)
0.2 0.5 GO:0009216 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) AMP salvage(GO:0044209) adenosine biosynthetic process(GO:0046086)
0.1 0.4 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
0.1 2.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 0.4 GO:0043987 histone H3-S10 phosphorylation(GO:0043987) cellular response to iron(III) ion(GO:0071283)
0.1 1.1 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 0.1 GO:0051542 elastin biosynthetic process(GO:0051542)
0.1 1.8 GO:0048368 notochord development(GO:0030903) lateral mesoderm development(GO:0048368)
0.1 4.0 GO:0016126 sterol biosynthetic process(GO:0016126)
0.1 2.9 GO:0048016 inositol phosphate-mediated signaling(GO:0048016)
0.1 0.6 GO:1900017 neutrophil differentiation(GO:0030223) positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 1.1 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.1 0.8 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.1 4.4 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.0 3.0 GO:0050909 sensory perception of taste(GO:0050909)
0.0 1.1 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 0.2 GO:0034244 negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.0 0.5 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.0 1.1 GO:0030500 regulation of bone mineralization(GO:0030500)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 11.3 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.2 4.8 GO:0098574 cytoplasmic side of lysosomal membrane(GO:0098574)
0.8 7.9 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.6 1.8 GO:0071149 TEAD-2-YAP complex(GO:0071149)
0.5 1.6 GO:0005592 collagen type XI trimer(GO:0005592)
0.2 1.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 0.4 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
0.1 3.8 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 2.6 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 3.0 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 0.8 GO:0016342 catenin complex(GO:0016342)
0.1 4.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 0.2 GO:0032044 DSIF complex(GO:0032044)
0.1 8.9 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 4.7 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 3.9 GO:0031526 brush border membrane(GO:0031526)
0.0 1.8 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 45.2 GO:0005615 extracellular space(GO:0005615)
0.0 4.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 3.1 GO:0000793 condensed chromosome(GO:0000793)
0.0 0.2 GO:0005686 U2 snRNP(GO:0005686)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.1 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
0.8 3.9 GO:0022841 potassium ion leak channel activity(GO:0022841)
0.6 7.2 GO:0070700 BMP receptor binding(GO:0070700)
0.5 4.4 GO:0047134 protein-disulfide reductase activity(GO:0047134)
0.5 3.8 GO:0003720 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964)
0.4 10.9 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.4 1.1 GO:0097677 STAT family protein binding(GO:0097677)
0.3 4.0 GO:0019534 toxin transporter activity(GO:0019534)
0.3 3.6 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.3 59.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 3.0 GO:0031681 G-protein beta-subunit binding(GO:0031681)
0.2 4.9 GO:0000062 fatty-acyl-CoA binding(GO:0000062)
0.2 1.8 GO:0000295 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346)
0.2 3.5 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 4.4 GO:0008527 taste receptor activity(GO:0008527)
0.2 1.1 GO:0043426 MRF binding(GO:0043426)
0.1 4.0 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 11.3 GO:0016209 antioxidant activity(GO:0016209)
0.1 0.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.1 1.8 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.1 4.4 GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547)
0.1 0.2 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
0.1 8.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.1 0.4 GO:0004322 ferroxidase activity(GO:0004322) metallochaperone activity(GO:0016530) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
0.1 7.9 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.6 GO:0003785 actin monomer binding(GO:0003785)
0.0 4.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.5 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.4 GO:0045125 bioactive lipid receptor activity(GO:0045125)
0.0 1.4 GO:0070063 RNA polymerase binding(GO:0070063)
0.0 0.6 GO:0005112 Notch binding(GO:0005112)
0.0 1.6 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.4 GO:0016503 pheromone receptor activity(GO:0016503)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 7.2 PID ALK2 PATHWAY ALK2 signaling events
0.3 7.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 7.9 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 3.8 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.1 1.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.0 8.9 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 1.6 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 1.1 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.4 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 0.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.0 0.6 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 7.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.3 3.9 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
0.2 4.4 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.2 3.1 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.2 4.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.2 3.4 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.1 4.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.1 3.8 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
0.1 0.6 REACTOME SIGNALING BY NOTCH4 Genes involved in Signaling by NOTCH4
0.1 2.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 3.5 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.1 4.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.1 3.6 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.1 1.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.1 REACTOME REGULATION OF IFNG SIGNALING Genes involved in Regulation of IFNG signaling
0.1 1.6 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.1 1.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.0 1.1 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
0.0 0.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.0 1.6 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.0 0.2 REACTOME ABORTIVE ELONGATION OF HIV1 TRANSCRIPT IN THE ABSENCE OF TAT Genes involved in Abortive elongation of HIV-1 transcript in the absence of Tat