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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Trp63

Z-value: 0.35

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Transcription factors associated with Trp63

Gene Symbol Gene ID Gene Info

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tp63rn6_v1_chr11_-_78341349_783413490.225.6e-05Click!

Activity profile of Trp63 motif

Sorted Z-values of Trp63 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_-_80807181 17.65 ENSRNOT00000040052
ENSRNOT00000090064
Cubn
cubilin
chr10_-_56465393 8.96 ENSRNOT00000056860
Tnk1
tyrosine kinase, non-receptor, 1
chr16_-_69132584 7.64 ENSRNOT00000017776
Adgra2
adhesion G protein-coupled receptor A2
chr16_-_50501716 7.02 ENSRNOT00000067486
Fat1
FAT atypical cadherin 1
chr12_-_23661009 6.98 ENSRNOT00000059451
Upk3bl
uroplakin 3B-like
chr16_-_50501921 6.76 ENSRNOT00000081023
Fat1
FAT atypical cadherin 1
chr17_-_90627101 5.82 ENSRNOT00000003349
Nid1
nidogen 1
chr2_-_219097619 5.13 ENSRNOT00000078806
Vcam1
vascular cell adhesion molecule 1
chr6_-_77848434 4.63 ENSRNOT00000034342
Slc25a21
solute carrier family 25 member 21
chr1_-_59347472 4.21 ENSRNOT00000017718
Lnpep
leucyl and cystinyl aminopeptidase
chr1_-_213987053 3.98 ENSRNOT00000072774
LOC100911519
p53-induced protein with a death domain-like
chr1_+_68436917 3.81 ENSRNOT00000088586
LOC108348118
leucyl-cystinyl aminopeptidase
chr4_+_62220736 3.47 ENSRNOT00000086377
Cald1
caldesmon 1
chr4_+_62221011 3.45 ENSRNOT00000041264
Cald1
caldesmon 1
chr5_+_58667885 3.43 ENSRNOT00000064755
Unc13b
unc-13 homolog B
chr10_-_10881844 3.09 ENSRNOT00000087118
ENSRNOT00000004416
Mgrn1
mahogunin ring finger 1
chr14_-_114583122 2.84 ENSRNOT00000084595
Sptbn1
spectrin, beta, non-erythrocytic 1
chr7_-_144269486 2.80 ENSRNOT00000090051
Atp5g2
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C2 (subunit 9)
chr20_+_11489456 2.72 ENSRNOT00000001632
Lrrc3
leucine rich repeat containing 3
chr5_+_135354700 2.58 ENSRNOT00000021850
Ipp
intracisternal A particle-promoted polypeptide
chr7_-_31784192 2.44 ENSRNOT00000010869
Apaf1
apoptotic peptidase activating factor 1
chr1_-_214423881 2.21 ENSRNOT00000025290
Pidd1
p53-induced death domain protein 1
chr11_-_62128044 1.98 ENSRNOT00000093141
Zbtb20
zinc finger and BTB domain containing 20
chr7_-_2961873 1.89 ENSRNOT00000067441
Rps15-ps2
ribosomal protein S15, pseudogene 2
chr7_-_143497108 1.73 ENSRNOT00000048613
Krt76
keratin 76
chr10_-_89374516 1.60 ENSRNOT00000028084
Vat1
vesicle amine transport 1
chr18_+_60392376 1.38 ENSRNOT00000023890
Nedd4l
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr13_+_48679774 1.35 ENSRNOT00000075674
Nucks1
nuclear casein kinase and cyclin-dependent kinase substrate 1
chr9_-_16807966 1.32 ENSRNOT00000073160
Rps19
ribosomal protein S19
chr15_+_34552410 1.09 ENSRNOT00000027802
Khnyn
KH and NYN domain containing
chr1_+_81750928 1.09 ENSRNOT00000027246
NEWGENE_68440
ribosomal protein S19
chr15_-_33537146 0.67 ENSRNOT00000019992
Ppp1r3e
protein phosphatase 1, regulatory subunit 3E
chr16_+_61130755 0.58 ENSRNOT00000042609
AABR07026048.1

chr10_-_64657089 0.42 ENSRNOT00000080703
Abr
active BCR-related
chr3_+_75848904 0.29 ENSRNOT00000042996
Olr583
olfactory receptor 583
chr19_+_22699808 0.29 ENSRNOT00000023169
RGD1308706
similar to RIKEN cDNA 4921524J17
chr2_-_250981623 0.24 ENSRNOT00000018435
Clca2
chloride channel accessory 2
chr5_-_38923095 0.20 ENSRNOT00000009146
AABR07047593.1

chr6_-_132797675 0.16 ENSRNOT00000006128
Wars
tryptophanyl-tRNA synthetase
chr13_+_78805347 0.06 ENSRNOT00000003748
Serpinc1
serpin family C member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp63

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 17.6 GO:0015889 cobalamin transport(GO:0015889)
2.5 7.6 GO:0090210 regulation of establishment of blood-brain barrier(GO:0090210)
1.4 4.2 GO:0010813 neuropeptide catabolic process(GO:0010813)
0.5 5.1 GO:0022614 membrane to membrane docking(GO:0022614)
0.5 3.4 GO:0099525 positive regulation of synaptic vesicle priming(GO:0010808) presynaptic dense core granule exocytosis(GO:0099525)
0.4 5.8 GO:0032836 glomerular basement membrane development(GO:0032836)
0.4 3.1 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.3 1.4 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.3 1.3 GO:0019042 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.3 1.3 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.3 13.8 GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197)
0.3 2.4 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.3 1.6 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.3 2.8 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.2 3.8 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
0.1 2.2 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 0.4 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
0.1 9.0 GO:0046580 negative regulation of Ras protein signal transduction(GO:0046580)
0.1 1.7 GO:0048733 sebaceous gland development(GO:0048733)
0.1 2.8 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 0.7 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
0.1 2.0 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 6.9 GO:0032092 positive regulation of protein binding(GO:0032092)
0.1 2.7 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 0.2 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
0.0 1.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.0 0.1 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 5.1 GO:0071065 alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065)
1.3 17.6 GO:0043202 lysosomal lumen(GO:0043202)
1.2 6.9 GO:0030478 actin cap(GO:0030478)
0.5 2.4 GO:0043293 apoptosome(GO:0043293)
0.4 3.4 GO:0044305 calyx of Held(GO:0044305)
0.3 4.2 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 2.8 GO:0008091 spectrin(GO:0008091) cuticular plate(GO:0032437)
0.2 2.8 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.2 5.8 GO:0005605 basal lamina(GO:0005605)
0.1 13.8 GO:0030175 filopodium(GO:0030175)
0.1 0.7 GO:0042587 glycogen granule(GO:0042587)
0.1 9.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 3.1 GO:0005769 early endosome(GO:0005769)
0.0 4.6 GO:0005743 mitochondrial inner membrane(GO:0005743)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 17.6 GO:0030492 hemoglobin binding(GO:0030492)
0.7 5.8 GO:0043237 laminin-1 binding(GO:0043237)
0.6 4.2 GO:0001595 angiotensin receptor activity(GO:0001595)
0.5 5.1 GO:0008131 primary amine oxidase activity(GO:0008131)
0.4 3.4 GO:0019992 diacylglycerol binding(GO:0019992)
0.2 2.4 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 3.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 1.4 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 9.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.1 2.8 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 6.9 GO:0017022 myosin binding(GO:0017022)
0.1 2.8 GO:0030506 ankyrin binding(GO:0030506)
0.1 2.4 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 0.2 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
0.0 2.7 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 1.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 13.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 3.1 GO:0016874 ligase activity(GO:0016874)
0.0 2.0 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.2 2.4 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.1 4.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 5.8 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.2 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.2 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
1.0 17.6 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 6.9 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 3.4 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.1 5.1 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.8 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 2.4 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 1.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 4.6 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives