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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Trp53

Z-value: 1.30

Motif logo

Transcription factors associated with Trp53

Gene Symbol Gene ID Gene Info

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tp53rn6_v1_chr10_+_56187020_561870200.808.7e-73Click!

Activity profile of Trp53 motif

Sorted Z-values of Trp53 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_82369493 50.82 ENSRNOT00000003733
selectin L
chr20_+_5509059 47.46 ENSRNOT00000065349
kinesin family member C1
chr17_+_44738643 45.95 ENSRNOT00000087643
histone H2A type 1-like
chr4_-_170841187 45.61 ENSRNOT00000007485
ADP-ribosyltransferase 4
chr4_+_78382287 44.57 ENSRNOT00000084927
GTPase, IMAP family member 5
chr3_-_92749121 40.85 ENSRNOT00000008760
CD44 molecule (Indian blood group)
chr13_+_27465930 38.67 ENSRNOT00000003314
serpin family B member 10
chr5_+_149056078 37.56 ENSRNOT00000083028
lysosomal protein transmembrane 5
chr13_+_26903052 37.03 ENSRNOT00000003625
serpin family B member 5
chr19_+_19395655 36.20 ENSRNOT00000019130
sorting nexin 20
chr13_+_48427038 35.30 ENSRNOT00000009241
cathepsin E
chr3_-_55451798 32.59 ENSRNOT00000008837
SPC25, NDC80 kinetochore complex component
chr3_+_18706988 32.43 ENSRNOT00000074650

chr1_-_214423881 30.12 ENSRNOT00000025290
p53-induced death domain protein 1
chr20_+_7788084 27.65 ENSRNOT00000000597
DEF6 guanine nucleotide exchange factor
chr16_+_74752655 27.58 ENSRNOT00000029266
cytoskeleton associated protein 2
chr15_+_35002406 27.32 ENSRNOT00000091167
mast cell protease 1-like 4
chr8_+_47674321 27.10 ENSRNOT00000026170
ENSRNOT00000078776
tripartite motif-containing 29
chr17_-_43798383 25.99 ENSRNOT00000075069
similar to Histone H1.2 (H1 VAR.1) (H1c)
chr1_-_227175096 25.94 ENSRNOT00000054811

chr12_+_1903165 25.05 ENSRNOT00000083947

chr10_-_107424710 24.94 ENSRNOT00000004320
galectin 3 binding protein
chr5_-_137104993 24.45 ENSRNOT00000027271
protein tyrosine phosphatase, receptor type, F
chr5_-_153924896 24.08 ENSRNOT00000065247
grainyhead-like transcription factor 3
chr7_+_126736732 24.05 ENSRNOT00000022012
G-2 and S-phase expressed 1
chr17_+_44520537 23.68 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr20_+_3987230 23.36 ENSRNOT00000088615
transporter 1, ATP binding cassette subfamily B member
chr10_-_34242985 22.77 ENSRNOT00000046438
similar to novel protein
chr17_-_44520240 22.53 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr1_-_89329418 22.53 ENSRNOT00000033155
CD22 molecule
chr9_-_15410943 22.46 ENSRNOT00000074217
cyclin D3
chr2_+_96439286 21.97 ENSRNOT00000016091
interleukin 7
chr13_-_74520634 21.87 ENSRNOT00000077169
Ral GEF with PH domain and SH3 binding motif 2
chr14_+_77079402 21.14 ENSRNOT00000042200
solute carrier family 2 member 9
chr15_+_55126953 21.09 ENSRNOT00000021430
lysophosphatidic acid receptor 6
chr17_+_77224112 20.34 ENSRNOT00000024178
minichromosome maintenance 10 replication initiation factor
chr16_-_14360555 20.15 ENSRNOT00000065460
hypothetical gene supported by AF152002
chr11_+_64522130 19.78 ENSRNOT00000004315
uroplakin 1B
chr11_-_60547201 19.50 ENSRNOT00000093151
B and T lymphocyte associated
chr3_-_119611136 19.50 ENSRNOT00000016157
non-SMC condensin I complex, subunit H
chr13_-_27158628 18.35 ENSRNOT00000003475
serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A
chr20_-_32139789 17.86 ENSRNOT00000078140
serglycin
chr4_+_162437089 17.71 ENSRNOT00000038801
C-type lectin domain family 2 member D2
chr16_-_20383337 17.49 ENSRNOT00000025977
interleukin 12 receptor subunit beta 1
chr4_-_157263890 17.33 ENSRNOT00000065416
protein tyrosine phosphatase, non-receptor type 6
chr11_-_64853692 17.02 ENSRNOT00000002089
Cd80 molecule
chr1_-_162385575 17.01 ENSRNOT00000016540
thyroid hormone responsive
chr4_-_22307453 16.70 ENSRNOT00000047126
ATP binding cassette subfamily B member 1A
chr8_+_85489553 16.62 ENSRNOT00000082158
ribosomal protein L12, pseudogene 1
chr16_+_20110148 16.61 ENSRNOT00000080146
ENSRNOT00000025312
Janus kinase 3
chr4_+_162292305 16.17 ENSRNOT00000010098
C-type lectin domain family 2, member D
chr9_-_121931564 16.06 ENSRNOT00000056243
thymidylate synthetase
chr18_+_62174670 15.98 ENSRNOT00000025362
phorbol-12-myristate-13-acetate-induced protein 1
chr8_+_71125414 15.81 ENSRNOT00000021265
PIF1 5'-to-3' DNA helicase
chrX_-_104984341 15.79 ENSRNOT00000077996
XK related, X-linked
chr2_-_250981623 15.51 ENSRNOT00000018435
chloride channel accessory 2
chrX_+_28539158 15.49 ENSRNOT00000073535
toll-like receptor 8
chr11_-_60546997 15.37 ENSRNOT00000083124
ENSRNOT00000050092
B and T lymphocyte associated
chr3_-_156340913 15.36 ENSRNOT00000021452
MAF bZIP transcription factor B
chr10_+_107469377 15.32 ENSRNOT00000087404
C1q and tumor necrosis factor related protein 1
chr17_-_44527801 15.24 ENSRNOT00000089643
histone cluster 1 H2B family member k
chr10_-_63176463 15.11 ENSRNOT00000004717
solute carrier family 6 member 4
chr17_+_44528125 15.03 ENSRNOT00000084538
similar to Histone H2A type 1
chr12_+_38160464 15.02 ENSRNOT00000032249
hydroxycarboxylic acid receptor 2
chr11_+_84745904 14.71 ENSRNOT00000002617
kelch-like family member 6
chr1_+_84573496 14.67 ENSRNOT00000057158
similar to ribosomal protein L28
chr13_+_47454591 14.41 ENSRNOT00000005791
similar to specifically androgen-regulated protein
chr15_-_34603819 14.35 ENSRNOT00000067539
chymase 1
chr10_-_91027731 14.29 ENSRNOT00000084128
ENSRNOT00000093704
kinesin family member 18B
chr1_+_75233703 13.83 ENSRNOT00000064178
DNA ligase 1-like
chr3_+_177164359 13.53 ENSRNOT00000066837
RGD1561282
chr8_+_72743426 13.43 ENSRNOT00000072573
ribosomal protein S27-like
chr10_-_90415070 13.28 ENSRNOT00000055179
integrin subunit alpha 2b
chr6_+_24163026 13.14 ENSRNOT00000061284
limb bud and heart development
chr16_-_85306366 13.11 ENSRNOT00000089650
tumor necrosis factor superfamily member 13b
chr5_+_135442031 12.71 ENSRNOT00000090852
ENSRNOT00000034464
coiled-coil domain containing 17
chr1_+_77541359 12.69 ENSRNOT00000049028
40S ribosomal protein S19-like
chr14_-_81023682 12.46 ENSRNOT00000081570
regulator of G-protein signaling 12
chr16_+_2743823 12.44 ENSRNOT00000087873
Rho guanine nucleotide exchange factor 3
chr7_-_143852119 12.33 ENSRNOT00000016801
retinoic acid receptor, gamma
chr9_-_78693028 12.22 ENSRNOT00000036359
ATP binding cassette subfamily A member 12
chr3_+_21764377 12.21 ENSRNOT00000063938
G protein-coupled receptor 21
chr8_+_66296883 12.21 ENSRNOT00000018467
transducin-like enhancer of split 3
chr3_+_2643610 11.71 ENSRNOT00000037169
fucosyltransferase 7
chr5_+_162808646 11.59 ENSRNOT00000021155
dehydrogenase/reductase 3
chr2_-_206293599 11.54 ENSRNOT00000026213
DNA cross-link repair 1B
chr1_+_88078350 11.38 ENSRNOT00000048677
RAS guanyl releasing protein 4
chr5_+_171478555 11.21 ENSRNOT00000091417
ENSRNOT00000000169
multiple epidermal growth factor-like domains protein 6-like
chr20_-_6257604 11.20 ENSRNOT00000092489
serine/threonine kinase 38
chr18_-_4371899 10.77 ENSRNOT00000051207
60S ribosomal protein L7a-like
chr18_-_25314047 10.72 ENSRNOT00000079778

chr1_-_213987053 10.57 ENSRNOT00000072774
p53-induced protein with a death domain-like
chr8_+_128781395 10.57 ENSRNOT00000029766
C-C motif chemokine receptor 8
chr2_+_30685840 10.45 ENSRNOT00000031385
coiled-coil domain containing 125
chr2_-_189765415 10.42 ENSRNOT00000020815
solute carrier family 27 member 3
chr7_-_2588843 10.30 ENSRNOT00000088619
RNA binding motif, single stranded interacting protein 2
chr7_-_123892429 10.25 ENSRNOT00000037681
NFAT activating protein with ITAM motif 1
chrX_-_139916883 10.23 ENSRNOT00000090442
glypican 3
chr8_+_49378644 10.17 ENSRNOT00000007588
junction adhesion molecule like
chr10_+_11100917 9.94 ENSRNOT00000006067
coronin 7
chr12_-_13133219 9.88 ENSRNOT00000092292
diacylglycerol lipase, beta
chr17_-_8429338 9.86 ENSRNOT00000016390
transforming growth factor, beta induced
chr7_+_13938302 9.63 ENSRNOT00000009643
caspase 14
chr10_-_14061703 9.61 ENSRNOT00000017917
growth factor, augmenter of liver regeneration
chr17_-_78499881 9.57 ENSRNOT00000079260
family with sequence similarity 107, member B
chr5_-_155258392 9.46 ENSRNOT00000017065
complement C1q C chain
chr6_-_141365198 9.42 ENSRNOT00000040523

chr2_-_206293275 9.23 ENSRNOT00000080702
DNA cross-link repair 1B
chrX_-_31138675 9.23 ENSRNOT00000004456
Fanconi anemia, complementation group B
chr6_+_80188943 9.13 ENSRNOT00000059335
melanoma inhibitory activity 2
chr2_-_95106157 9.10 ENSRNOT00000041334
LRRGT00056
chr10_+_45289741 8.44 ENSRNOT00000066190
histone cluster 3, H2ba
chr4_-_148446303 8.38 ENSRNOT00000017633
arachidonate 5-lipoxygenase
chr10_+_83104622 8.28 ENSRNOT00000072972

chr4_+_100407658 7.97 ENSRNOT00000018562
capping actin protein, gelsolin like
chr7_-_117068332 7.91 ENSRNOT00000082433
family with sequence similarity 83, member H
chr3_-_125607735 7.69 ENSRNOT00000028901
fermitin family member 1
chr20_+_11365697 7.68 ENSRNOT00000001611
autoimmune regulator
chr3_-_72895740 7.57 ENSRNOT00000012568
fatty acid desaturase 2-like 1
chr8_-_83693472 7.51 ENSRNOT00000015947
family with sequence similarity 83, member B
chr13_+_48644604 7.47 ENSRNOT00000084259
ENSRNOT00000073669
RAB29, member RAS oncogene family
chr1_+_103172987 7.42 ENSRNOT00000018688
transmembrane protein 86A
chr10_+_107502695 7.40 ENSRNOT00000038088
endo-beta-N-acetylglucosaminidase
chr8_-_120446455 7.35 ENSRNOT00000085161
ENSRNOT00000042854
ENSRNOT00000037199
cAMP regulated phosphoprotein 21
chr9_+_95241609 7.33 ENSRNOT00000032634
ENSRNOT00000077416
UDP glucuronosyltransferase family 1 member A5
chr10_-_12990405 7.32 ENSRNOT00000078647
THO complex 6
chrX_-_71616997 7.15 ENSRNOT00000004406
C-X-C motif chemokine receptor 3
chr7_-_71048383 7.02 ENSRNOT00000005693
G protein-coupled receptor 182
chr16_+_20020444 7.01 ENSRNOT00000024827
6-phosphogluconolactonase
chr19_-_29802083 6.96 ENSRNOT00000024755

chr4_+_6282278 6.91 ENSRNOT00000010349
lysine methyltransferase 2C
chr20_-_5166252 6.85 ENSRNOT00000001138
allograft inflammatory factor 1
chr11_+_86715981 6.75 ENSRNOT00000050269
catechol-O-methyltransferase
chr8_+_106503504 6.59 ENSRNOT00000018755
retinol binding protein 2
chr1_+_239412884 6.56 ENSRNOT00000067384
transmembrane protein 2
chr3_+_151285249 6.49 ENSRNOT00000055254
protein C receptor
chr6_-_76270457 6.32 ENSRNOT00000009894
NFKB inhibitor alpha
chr1_+_226573105 6.21 ENSRNOT00000028074
cleavage and polyadenylation specific factor 7
chr13_+_112031594 6.19 ENSRNOT00000008440
laminin subunit beta 3
chr19_+_15339152 6.11 ENSRNOT00000060929
carboxylesterase 1A
chr14_+_83343330 6.11 ENSRNOT00000089198
phosphatidylserine decarboxylase
chr13_-_89343868 6.10 ENSRNOT00000058497
ENSRNOT00000035400
Fc fragment of IgG receptor IIb
chr17_+_78879058 5.98 ENSRNOT00000022043
oleoyl-ACP hydrolase
chr7_-_117679219 5.95 ENSRNOT00000071522
solute carrier family 39 member 4
chr6_+_10912383 5.92 ENSRNOT00000061747
ENSRNOT00000086247
tetratricopeptide repeat domain 7A
chr7_+_118507224 5.90 ENSRNOT00000075451
60S ribosomal protein L8
chr1_-_151106802 5.75 ENSRNOT00000021971
tyrosinase
chr8_+_33514042 5.74 ENSRNOT00000081614
ENSRNOT00000081525
potassium voltage-gated channel subfamily J member 1
chr11_+_53140599 5.73 ENSRNOT00000083438
BBX, HMG-box containing
chr2_+_154604832 5.69 ENSRNOT00000013777
vomeronasal 2 receptor 44
chr7_-_2986935 5.69 ENSRNOT00000081125
ENSRNOT00000006578
proliferation-associated 2G4
chr6_-_111176918 5.56 ENSRNOT00000016242
protein-O-mannosyltransferase 2
chrX_-_38026774 5.43 ENSRNOT00000074898
SH3 domain-containing kinase-binding protein 1
chr10_-_56511583 5.32 ENSRNOT00000021402
similar to RIKEN cDNA 2810408A11
chr7_-_28711761 5.20 ENSRNOT00000006249
PARP1 binding protein
chrX_+_22302485 5.17 ENSRNOT00000082902
lysine demethylase 5C
chr8_-_108801570 5.11 ENSRNOT00000091593
NCK adaptor protein 1
chr5_-_137014375 5.04 ENSRNOT00000066165
ENSRNOT00000091866
lysine demethylase 4A
chr4_+_102290338 5.02 ENSRNOT00000011067

chr1_+_201429771 5.01 ENSRNOT00000027836
pleckstrin homology domain containing A1
chr1_-_129776276 4.98 ENSRNOT00000051402
arrestin domain containing 4
chr10_+_84955864 4.92 ENSRNOT00000038572
Sp6 transcription factor
chr10_+_31561895 4.87 ENSRNOT00000048485
hepatitis A virus cellular receptor 2
chr12_-_30180115 4.86 ENSRNOT00000001202
CGRP receptor component
chr5_+_133865331 4.84 ENSRNOT00000035409
TAL bHLH transcription factor 1, erythroid differentiation factor
chr9_-_100306829 4.84 ENSRNOT00000038563
similar to hypothetical protein FLJ22671
chr20_-_3439983 4.68 ENSRNOT00000080822
ENSRNOT00000001099
immediate early response 3
chr14_+_107349414 4.64 ENSRNOT00000012255
similar to ribosomal protein L28
chr17_-_84488480 4.53 ENSRNOT00000000158
ENSRNOT00000075983
nebulette
chr7_-_140401686 4.42 ENSRNOT00000083955
FK506 binding protein 11
chr20_+_46707362 4.41 ENSRNOT00000071045

chr1_+_140584380 4.39 ENSRNOT00000064438
apoptosis enhancing nuclease
chr6_+_80218880 4.36 ENSRNOT00000006995
melanoma inhibitory activity 2
chr5_-_152473868 4.32 ENSRNOT00000022130
family with sequence similarity 110, member D
chr5_-_113621134 4.27 ENSRNOT00000037206
leucine rich repeat containing 19
chr20_+_1889652 4.25 ENSRNOT00000068508
ENSRNOT00000000996
olfactory receptor 1746
chr17_-_17947777 4.25 ENSRNOT00000036876
ring finger protein 144B
chr9_+_17216495 4.25 ENSRNOT00000026331
MAD2L1 binding protein
chr17_+_90802393 4.22 ENSRNOT00000003535
EDAR-associated death domain
chr4_-_150616895 4.22 ENSRNOT00000073562
ankyrin repeat domain 26
chrX_-_84167717 4.13 ENSRNOT00000006415
premature ovarian failure 1B
chr3_-_64766472 4.02 ENSRNOT00000037684
CWC22 spliceosome associated protein homolog
chr7_+_72985495 3.91 ENSRNOT00000008361
matrilin 2
chr3_-_122006803 3.88 ENSRNOT00000089660
similar to hypothetical protein F830045P16
chr10_+_25890943 3.85 ENSRNOT00000086814
NudC domain containing 2
chr3_-_162080192 3.84 ENSRNOT00000025820
osteoclast stimulatory transmembrane protein
chr8_-_119012671 3.75 ENSRNOT00000028435
parathyroid hormone 1 receptor
chr4_-_117758135 3.70 ENSRNOT00000087750
N-acetyltransferase 8 (GCN5-related) family member 4
chr13_-_111849653 3.67 ENSRNOT00000006395
digestive organ expansion factor homolog (zebrafish)
chr1_-_198638944 3.57 ENSRNOT00000023285
Cd2 (cytoplasmic tail) binding protein 2
chr6_+_143901280 3.54 ENSRNOT00000091884
ENSRNOT00000005648
zinc finger protein 386 (Kruppel-like)
chr1_+_175839108 3.54 ENSRNOT00000023741
CTR9 homolog, Paf1/RNA polymerase II complex component
chr5_+_159735008 3.54 ENSRNOT00000064310
REM2 and RAB-like small GTPase 1
chr6_+_26686033 3.51 ENSRNOT00000081167
solute carrier family 5 member 6
chr1_-_266914093 3.50 ENSRNOT00000027526
calcium homeostasis modulator 2
chr19_+_11450760 3.50 ENSRNOT00000026297
nudix hydrolase 21
chr1_-_164307084 3.49 ENSRNOT00000086091
serpin family H member 1
chr5_-_101138427 3.44 ENSRNOT00000058615
Fras1 related extracellular matrix 1
chr19_+_49637016 3.41 ENSRNOT00000016880
beta-carotene oxygenase 1
chr8_+_130749838 3.36 ENSRNOT00000079273
SNF related kinase

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.2 40.9 GO:1900625 regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
7.8 23.4 GO:0046967 cytosol to ER transport(GO:0046967) peptide antigen transport(GO:0046968)
7.4 44.6 GO:0002729 positive regulation of natural killer cell cytokine production(GO:0002729)
6.0 17.9 GO:0033364 mast cell secretory granule organization(GO:0033364)
5.6 50.8 GO:0070543 response to linoleic acid(GO:0070543)
5.5 16.6 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) FasL biosynthetic process(GO:0045210)
5.5 21.9 GO:0032485 regulation of Ral protein signal transduction(GO:0032485)
5.4 16.1 GO:0009177 pyrimidine deoxyribonucleoside monophosphate biosynthetic process(GO:0009177) dUMP metabolic process(GO:0046078)
5.3 16.0 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
5.2 15.5 GO:2001183 negative regulation of interleukin-12 secretion(GO:2001183)
4.8 9.6 GO:0072717 cellular response to actinomycin D(GO:0072717)
4.8 14.3 GO:0042222 interleukin-1 biosynthetic process(GO:0042222)
4.3 17.3 GO:0033277 abortive mitotic cell cycle(GO:0033277)
4.2 16.7 GO:1905235 carbohydrate export(GO:0033231) daunorubicin transport(GO:0043215) response to borneol(GO:1905230) cellular response to borneol(GO:1905231) response to codeine(GO:1905233) response to quercetin(GO:1905235) drug transport across blood-brain barrier(GO:1990962) establishment of blood-retinal barrier(GO:1990963)
4.2 20.8 GO:0031860 telomeric 3' overhang formation(GO:0031860)
4.1 12.3 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
4.1 24.4 GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387)
3.9 19.5 GO:0010032 meiotic chromosome condensation(GO:0010032)
3.9 34.9 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
3.8 15.4 GO:0021571 rhombomere 5 development(GO:0021571)
3.8 7.7 GO:2000410 regulation of thymocyte migration(GO:2000410)
3.8 15.3 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
3.2 26.0 GO:0016584 nucleosome positioning(GO:0016584)
3.2 9.6 GO:0070268 cornification(GO:0070268)
3.2 15.8 GO:0044806 G-quadruplex DNA unwinding(GO:0044806)
3.1 9.2 GO:1905168 positive regulation of double-strand break repair via homologous recombination(GO:1905168)
3.0 15.1 GO:0032227 negative regulation of synaptic transmission, dopaminergic(GO:0032227)
3.0 9.0 GO:2001201 regulation of transforming growth factor-beta secretion(GO:2001201)
2.6 13.1 GO:0002636 positive regulation of germinal center formation(GO:0002636) B cell costimulation(GO:0031296)
2.6 10.2 GO:0072138 mesenchymal cell proliferation involved in ureteric bud development(GO:0072138)
2.5 15.0 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
2.4 12.2 GO:0035627 ceramide transport(GO:0035627)
2.3 13.8 GO:0033567 DNA replication, Okazaki fragment processing(GO:0033567)
2.3 6.8 GO:0014739 positive regulation of muscle hyperplasia(GO:0014739)
2.3 6.8 GO:0045963 negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963)
2.2 13.5 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
2.2 35.3 GO:0016540 protein autoprocessing(GO:0016540)
2.2 13.1 GO:1904674 positive regulation of somatic stem cell population maintenance(GO:1904674)
2.1 8.4 GO:0002540 leukotriene production involved in inflammatory response(GO:0002540)
2.1 12.5 GO:0023021 termination of signal transduction(GO:0023021)
2.1 31.0 GO:0061029 eyelid development in camera-type eye(GO:0061029)
2.0 5.9 GO:0034224 cellular response to zinc ion starvation(GO:0034224)
2.0 23.5 GO:0030213 hyaluronan biosynthetic process(GO:0030213)
1.9 5.7 GO:1901979 regulation of inward rectifier potassium channel activity(GO:1901979)
1.9 5.6 GO:1904098 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
1.8 12.5 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
1.7 5.1 GO:0002191 cap-dependent translational initiation(GO:0002191)
1.7 10.2 GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing(GO:0060054)
1.7 5.1 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
1.7 27.0 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
1.6 4.9 GO:0002835 negative regulation of response to tumor cell(GO:0002835) negative regulation of immune response to tumor cell(GO:0002838) negative regulation of natural killer cell mediated immune response to tumor cell(GO:0002856) negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002859)
1.6 42.9 GO:0006471 protein ADP-ribosylation(GO:0006471)
1.6 9.5 GO:0045650 negative regulation of macrophage differentiation(GO:0045650)
1.5 6.1 GO:0002434 immune complex clearance(GO:0002434)
1.5 4.5 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
1.5 14.7 GO:0002467 germinal center formation(GO:0002467)
1.4 11.6 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
1.4 4.2 GO:0061152 trachea submucosa development(GO:0061152) trachea gland development(GO:0061153)
1.3 17.5 GO:0002827 positive regulation of T-helper 1 type immune response(GO:0002827)
1.3 11.7 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
1.3 2.6 GO:0070103 regulation of interleukin-6-mediated signaling pathway(GO:0070103)
1.3 47.5 GO:0007080 mitotic metaphase plate congression(GO:0007080)
1.3 3.8 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
1.3 6.3 GO:0070427 nucleotide-binding oligomerization domain containing 1 signaling pathway(GO:0070427)
1.2 3.5 GO:0051037 regulation of transcription involved in meiotic cell cycle(GO:0051037)
1.2 3.5 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
1.1 10.3 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
1.1 17.0 GO:0046641 positive regulation of alpha-beta T cell proliferation(GO:0046641)
1.1 21.1 GO:0046415 urate metabolic process(GO:0046415)
1.1 15.3 GO:0031571 mitotic G1 DNA damage checkpoint(GO:0031571)
1.1 3.2 GO:1902463 protein localization to cell leading edge(GO:1902463)
1.0 22.0 GO:0002360 T cell lineage commitment(GO:0002360)
1.0 15.2 GO:0002227 innate immune response in mucosa(GO:0002227)
0.9 37.0 GO:0060512 prostate gland morphogenesis(GO:0060512)
0.9 7.5 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.9 20.1 GO:0050832 defense response to fungus(GO:0050832)
0.9 6.0 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.8 0.8 GO:1905072 cardiac jelly development(GO:1905072)
0.8 6.6 GO:0006776 vitamin A metabolic process(GO:0006776)
0.8 7.3 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.8 2.3 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
0.8 2.3 GO:0002086 vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure(GO:0002025) diaphragm contraction(GO:0002086)
0.7 69.6 GO:0006342 chromatin silencing(GO:0006342)
0.7 2.1 GO:0002001 renin secretion into blood stream(GO:0002001)
0.7 3.5 GO:0003433 chondrocyte development involved in endochondral bone morphogenesis(GO:0003433)
0.7 4.9 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.7 7.3 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.7 20.3 GO:0006270 DNA replication initiation(GO:0006270)
0.7 39.9 GO:0007019 microtubule depolymerization(GO:0007019)
0.7 17.0 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.6 5.2 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
0.6 5.0 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
0.6 22.8 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.6 21.1 GO:0051482 positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482)
0.6 9.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.6 9.9 GO:0042136 neurotransmitter biosynthetic process(GO:0042136)
0.6 1.7 GO:0016128 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
0.5 4.4 GO:0051182 coenzyme transport(GO:0051182)
0.5 1.6 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.5 2.1 GO:0060174 limb bud formation(GO:0060174)
0.5 7.2 GO:1900118 T cell chemotaxis(GO:0010818) negative regulation of execution phase of apoptosis(GO:1900118)
0.5 2.9 GO:0006572 tyrosine catabolic process(GO:0006572)
0.5 4.7 GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway(GO:1901029)
0.5 3.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.4 32.6 GO:0007052 mitotic spindle organization(GO:0007052)
0.4 12.6 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.4 4.2 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.4 7.4 GO:0006517 protein deglycosylation(GO:0006517)
0.4 6.1 GO:0006646 phosphatidylethanolamine biosynthetic process(GO:0006646)
0.4 5.2 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.4 8.0 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.4 3.8 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.4 2.6 GO:0002439 chronic inflammatory response to antigenic stimulus(GO:0002439) S-adenosylmethionine cycle(GO:0033353)
0.4 1.8 GO:1904179 positive regulation of adipose tissue development(GO:1904179)
0.4 31.0 GO:0006334 nucleosome assembly(GO:0006334)
0.3 4.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.3 5.8 GO:0042438 melanin biosynthetic process(GO:0042438)
0.3 27.1 GO:1900181 negative regulation of protein localization to nucleus(GO:1900181)
0.3 12.2 GO:0007212 dopamine receptor signaling pathway(GO:0007212)
0.3 0.3 GO:0050713 negative regulation of interleukin-1 beta secretion(GO:0050713)
0.3 5.0 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 13.3 GO:0070527 platelet aggregation(GO:0070527)
0.2 4.9 GO:0042481 regulation of odontogenesis(GO:0042481)
0.2 2.6 GO:0036065 fucosylation(GO:0036065)
0.2 6.5 GO:0050819 negative regulation of coagulation(GO:0050819)
0.2 1.5 GO:0043031 negative regulation of macrophage activation(GO:0043031)
0.2 7.9 GO:0044380 protein localization to cytoskeleton(GO:0044380)
0.2 3.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.2 3.4 GO:0042574 retinal metabolic process(GO:0042574)
0.2 10.6 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.2 0.6 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.2 11.2 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.2 2.4 GO:0019430 removal of superoxide radicals(GO:0019430)
0.2 2.4 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.1 4.4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.1 16.2 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 7.4 GO:0034605 cellular response to heat(GO:0034605)
0.1 1.7 GO:0010155 regulation of proton transport(GO:0010155)
0.1 1.5 GO:0032096 negative regulation of response to food(GO:0032096)
0.1 2.9 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.1 8.9 GO:0015908 fatty acid transport(GO:0015908)
0.1 1.6 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 7.5 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.1 24.6 GO:0016485 protein processing(GO:0016485)
0.1 4.4 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.4 GO:0031179 peptide modification(GO:0031179)
0.1 5.9 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 9.9 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 24.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 3.5 GO:0006378 mRNA polyadenylation(GO:0006378)
0.1 3.5 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 2.5 GO:0051225 spindle assembly(GO:0051225)
0.1 9.6 GO:0007605 sensory perception of sound(GO:0007605)
0.1 2.6 GO:0035987 endodermal cell differentiation(GO:0035987)
0.1 2.1 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 0.9 GO:0042226 interleukin-6 biosynthetic process(GO:0042226)
0.1 3.9 GO:0031102 neuron projection regeneration(GO:0031102)
0.0 1.8 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 0.3 GO:0001865 NK T cell differentiation(GO:0001865)
0.0 9.9 GO:0006397 mRNA processing(GO:0006397)
0.0 0.0 GO:0010693 negative regulation of alkaline phosphatase activity(GO:0010693)
0.0 2.0 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0019682 pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682)
0.0 0.2 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.0 6.2 GO:0030855 epithelial cell differentiation(GO:0030855)
0.0 1.4 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.6 40.9 GO:0035692 macrophage migration inhibitory factor receptor complex(GO:0035692)
6.5 32.6 GO:0031262 Ndc80 complex(GO:0031262)
3.3 23.4 GO:0042825 TAP complex(GO:0042825)
2.4 19.5 GO:0000796 condensin complex(GO:0000796)
2.2 17.3 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
2.0 12.2 GO:0097209 epidermal lamellar body(GO:0097209)
2.0 20.3 GO:0031298 replication fork protection complex(GO:0031298)
1.8 14.3 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
1.5 7.5 GO:0020003 symbiont-containing vacuole(GO:0020003)
1.4 141.8 GO:0000786 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
1.3 4.0 GO:0071006 U2-type catalytic step 1 spliceosome(GO:0071006)
1.3 16.7 GO:0046581 intercellular canaliculus(GO:0046581)
1.1 8.0 GO:0090543 Flemming body(GO:0090543)
0.9 51.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.9 2.6 GO:0005896 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
0.8 8.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.8 47.5 GO:0005871 kinesin complex(GO:0005871)
0.7 10.4 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.7 7.3 GO:0000347 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.7 6.3 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.7 6.2 GO:0005610 laminin-5 complex(GO:0005610)
0.7 13.5 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.7 26.7 GO:0098636 protein complex involved in cell adhesion(GO:0098636)
0.7 17.9 GO:0042629 mast cell granule(GO:0042629)
0.6 9.2 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
0.5 6.9 GO:0044666 MLL3/4 complex(GO:0044666)
0.5 3.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.5 3.5 GO:0042382 paraspeckles(GO:0042382)
0.5 38.9 GO:0031901 early endosome membrane(GO:0031901)
0.5 145.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.4 22.5 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 1.3 GO:0005577 fibrinogen complex(GO:0005577)
0.4 26.1 GO:0005581 collagen trimer(GO:0005581)
0.4 26.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.4 1.1 GO:0036117 hyaluranon cable(GO:0036117)
0.3 6.2 GO:0005849 mRNA cleavage factor complex(GO:0005849)
0.3 6.8 GO:0001891 phagocytic cup(GO:0001891)
0.3 1.6 GO:0009331 glycerol-3-phosphate dehydrogenase complex(GO:0009331)
0.3 2.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 4.9 GO:0042575 DNA polymerase complex(GO:0042575)
0.3 29.1 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.3 2.5 GO:0070652 HAUS complex(GO:0070652)
0.3 5.0 GO:0005721 pericentric heterochromatin(GO:0005721)
0.2 25.2 GO:0072562 blood microparticle(GO:0072562)
0.2 20.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.2 14.3 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.2 9.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.2 4.1 GO:0030057 desmosome(GO:0030057)
0.2 15.4 GO:0045095 keratin filament(GO:0045095)
0.2 17.2 GO:0005604 basement membrane(GO:0005604)
0.2 4.9 GO:0001772 immunological synapse(GO:0001772)
0.2 98.5 GO:0000323 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.2 7.7 GO:0031941 filamentous actin(GO:0031941)
0.2 3.6 GO:0005682 U5 snRNP(GO:0005682)
0.2 14.2 GO:0010008 endosome membrane(GO:0010008)
0.2 8.3 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 17.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 1.6 GO:0000812 Swr1 complex(GO:0000812)
0.1 8.1 GO:0031526 brush border membrane(GO:0031526)
0.1 2.9 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 23.8 GO:0016324 apical plasma membrane(GO:0016324)
0.1 8.1 GO:0043296 apical junction complex(GO:0043296)
0.1 1.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 28.4 GO:0005667 transcription factor complex(GO:0005667)
0.1 7.8 GO:0005802 trans-Golgi network(GO:0005802)
0.1 69.5 GO:0005615 extracellular space(GO:0005615)
0.1 2.6 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 18.3 GO:0009986 cell surface(GO:0009986)
0.1 17.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 3.8 GO:0000922 spindle pole(GO:0000922)
0.0 18.6 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.4 GO:0001917 photoreceptor inner segment(GO:0001917)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
7.8 23.4 GO:0015433 peptide antigen-transporting ATPase activity(GO:0015433) tapasin binding(GO:0046980)
6.1 24.4 GO:0035373 chondroitin sulfate proteoglycan binding(GO:0035373)
5.7 45.6 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
5.3 21.1 GO:0070915 lysophosphatidic acid receptor activity(GO:0070915)
5.0 15.1 GO:0015222 serotonin transmembrane transporter activity(GO:0015222)
4.4 17.5 GO:0005143 interleukin-12 receptor binding(GO:0005143)
4.2 41.7 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
4.1 12.2 GO:0001588 dopamine neurotransmitter receptor activity, coupled via Gs(GO:0001588)
3.9 19.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
3.3 16.7 GO:0090555 phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
3.2 9.6 GO:0016971 flavin-linked sulfhydryl oxidase activity(GO:0016971)
3.0 20.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
2.8 8.4 GO:0004051 arachidonate 5-lipoxygenase activity(GO:0004051)
2.6 15.8 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
2.4 14.6 GO:0070051 fibrinogen binding(GO:0070051)
2.4 4.9 GO:0001635 calcitonin gene-related peptide receptor activity(GO:0001635)
2.4 14.3 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
2.3 7.0 GO:0001605 adrenomedullin receptor activity(GO:0001605)
2.2 13.5 GO:0042954 lipoprotein transporter activity(GO:0042954)
2.2 50.8 GO:0051861 glycolipid binding(GO:0051861)
2.1 21.1 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
2.1 12.5 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
1.6 16.1 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.6 7.9 GO:1990254 keratin filament binding(GO:1990254)
1.5 6.1 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
1.5 13.4 GO:0008494 translation activator activity(GO:0008494)
1.5 10.4 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.4 5.8 GO:0016716 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen(GO:0016716)
1.4 5.7 GO:0015272 ATP-activated inward rectifier potassium channel activity(GO:0015272)
1.4 35.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
1.3 27.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.3 17.6 GO:0003688 DNA replication origin binding(GO:0003688)
1.2 11.1 GO:0003909 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
1.2 10.4 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
1.1 5.6 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.0 12.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
1.0 7.2 GO:0019958 C-X-C chemokine binding(GO:0019958)
1.0 5.0 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.9 7.5 GO:0004630 phospholipase D activity(GO:0004630)
0.9 9.6 GO:0097200 cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.9 2.6 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.9 33.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.8 97.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 22.5 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.8 2.3 GO:0004939 beta-adrenergic receptor activity(GO:0004939) bradykinin receptor binding(GO:0031711)
0.7 6.6 GO:0019841 retinol binding(GO:0019841)
0.7 61.8 GO:0003777 microtubule motor activity(GO:0003777)
0.7 10.6 GO:0016493 C-C chemokine receptor activity(GO:0016493)
0.7 15.0 GO:0016502 purinergic nucleotide receptor activity(GO:0001614) nucleotide receptor activity(GO:0016502)
0.6 2.6 GO:0004013 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.6 5.2 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.6 6.1 GO:0019864 IgG binding(GO:0019864)
0.5 4.4 GO:0090482 vitamin transmembrane transporter activity(GO:0090482)
0.5 11.6 GO:0004745 retinol dehydrogenase activity(GO:0004745)
0.5 10.2 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.5 24.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.5 2.4 GO:0016721 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 3.1 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.4 1.7 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.4 48.3 GO:0031490 chromatin DNA binding(GO:0031490)
0.4 6.0 GO:0004312 fatty acid synthase activity(GO:0004312)
0.4 3.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.4 9.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.4 2.1 GO:0042289 MHC class II protein binding(GO:0042289)
0.3 12.5 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 6.8 GO:0008171 O-methyltransferase activity(GO:0008171)
0.3 13.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.3 25.3 GO:0005518 collagen binding(GO:0005518)
0.3 1.6 GO:0004367 glycerol-3-phosphate dehydrogenase [NAD+] activity(GO:0004367)
0.3 7.5 GO:0070840 dynein complex binding(GO:0070840)
0.3 3.2 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.3 6.9 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.3 2.3 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.3 17.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 4.5 GO:0031005 filamin binding(GO:0031005)
0.3 5.0 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.2 3.1 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.2 7.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 7.7 GO:0045182 translation regulator activity(GO:0045182)
0.2 3.7 GO:0019843 rRNA binding(GO:0019843)
0.2 1.1 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 5.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.2 6.3 GO:0051059 NF-kappaB binding(GO:0051059)
0.2 15.5 GO:0003725 double-stranded RNA binding(GO:0003725) single-stranded RNA binding(GO:0003727)
0.2 116.0 GO:0046982 protein heterodimerization activity(GO:0046982)
0.2 2.2 GO:0001727 lipid kinase activity(GO:0001727)
0.2 37.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 3.5 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.2 3.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 5.0 GO:0031369 translation initiation factor binding(GO:0031369)
0.2 7.3 GO:0016859 cis-trans isomerase activity(GO:0016859)
0.1 21.2 GO:0008083 growth factor activity(GO:0008083)
0.1 3.4 GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen(GO:0016702)
0.1 1.9 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 10.2 GO:0005178 integrin binding(GO:0005178)
0.1 45.9 GO:0005525 GTP binding(GO:0005525)
0.1 1.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 0.2 GO:0030156 benzodiazepine receptor binding(GO:0030156)
0.1 12.0 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.1 3.8 GO:0017046 peptide hormone binding(GO:0017046)
0.1 6.3 GO:0051082 unfolded protein binding(GO:0051082)
0.1 0.4 GO:0036374 gamma-glutamyltransferase activity(GO:0003840) glutathione hydrolase activity(GO:0036374)
0.1 7.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.1 1.7 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 16.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 4.4 GO:0004527 exonuclease activity(GO:0004527)
0.1 1.5 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 5.0 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 3.0 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 3.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 10.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.9 GO:0008565 protein transporter activity(GO:0008565)
0.0 2.2 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 3.1 GO:0001047 core promoter binding(GO:0001047)
0.0 1.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0015643 toxic substance binding(GO:0015643)
0.0 4.3 GO:0008134 transcription factor binding(GO:0008134)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.1 91.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.5 16.6 ST JAK STAT PATHWAY Jak-STAT Pathway
1.3 81.9 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.8 20.1 PID IL27 PATHWAY IL27-mediated signaling events
0.7 22.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.7 17.0 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.7 52.3 PID BCR 5PATHWAY BCR signaling pathway
0.5 20.7 PID ARF6 PATHWAY Arf6 signaling events
0.4 19.5 PID AURORA B PATHWAY Aurora B signaling
0.4 17.9 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 12.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.4 6.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 23.0 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 54.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3 9.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.3 67.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.3 15.8 PID TELOMERASE PATHWAY Regulation of Telomerase
0.2 16.1 PID E2F PATHWAY E2F transcription factor network
0.2 7.2 PID CXCR3 PATHWAY CXCR3-mediated signaling events
0.2 9.2 PID FANCONI PATHWAY Fanconi anemia pathway
0.2 6.1 PID HNF3A PATHWAY FOXA1 transcription factor network
0.2 6.6 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.2 5.0 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 4.5 PID ERBB1 INTERNALIZATION PATHWAY Internalization of ErbB1
0.1 33.8 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 5.7 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 3.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.1 3.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 0.8 PID ALK1 PATHWAY ALK1 signaling events
0.0 1.3 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.0 0.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 41.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
2.6 38.6 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
1.8 21.1 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
1.7 17.3 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
1.7 15.5 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION IN TLR7 8 OR 9 SIGNALING Genes involved in TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
1.5 47.5 REACTOME KINESINS Genes involved in Kinesins
1.5 37.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
1.3 23.4 REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.2 21.1 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
1.2 56.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.9 9.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
0.8 16.1 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.8 13.3 REACTOME GRB2 SOS PROVIDES LINKAGE TO MAPK SIGNALING FOR INTERGRINS Genes involved in GRB2:SOS provides linkage to MAPK signaling for Intergrins
0.8 20.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.7 17.0 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.7 26.6 REACTOME COSTIMULATION BY THE CD28 FAMILY Genes involved in Costimulation by the CD28 family
0.7 16.0 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.7 22.5 REACTOME G1 PHASE Genes involved in G1 Phase
0.7 12.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.6 6.3 REACTOME NFKB IS ACTIVATED AND SIGNALS SURVIVAL Genes involved in NF-kB is activated and signals survival
0.6 10.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.6 9.9 REACTOME AMYLOIDS Genes involved in Amyloids
0.5 9.7 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.5 12.9 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 5.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.4 32.6 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.4 7.3 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.4 9.2 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.4 17.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 4.4 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.3 5.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.3 12.2 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 5.4 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.2 2.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.2 17.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.2 9.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 23.2 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.2 6.6 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 5.7 REACTOME INWARDLY RECTIFYING K CHANNELS Genes involved in Inwardly rectifying K+ channels
0.1 8.7 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 3.0 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.1 2.3 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 4.8 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.1 1.7 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 2.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 2.9 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.0 1.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 1.8 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 2.9 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.1 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation