ISMARA results: Trp53

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Trp53

Z-value: 1.30

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Transcription factors associated with Trp53

Gene Symbol	Gene ID	Gene Info

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tp53	rn6_v1_chr10_+_56187020_56187020	0.80	8.7e-73	Click!

Activity profile of Trp53 motif

Sorted Z-values of Trp53 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr13_+_82369493 Show fit	50.82	ENSRNOT00000003733	Sell NCBI RGD Ensembl Show fit	selectin L
chr20_+_5509059 Show fit	47.46	ENSRNOT00000065349	Kifc1 NCBI RGD Ensembl Show fit	kinesin family member C1
chr17_+_44738643 Show fit	45.95	ENSRNOT00000087643	LOC100910554 NCBI RGD Ensembl Show fit	histone H2A type 1-like
chr4_-_170841187 Show fit	45.61	ENSRNOT00000007485	Art4 NCBI RGD Ensembl Show fit	ADP-ribosyltransferase 4
chr4_+_78382287 Show fit	44.57	ENSRNOT00000084927	Gimap5 NCBI RGD Ensembl Show fit	GTPase, IMAP family member 5
chr3_-_92749121 Show fit	40.85	ENSRNOT00000008760	Cd44 NCBI RGD Ensembl Show fit	CD44 molecule (Indian blood group)
chr13_+_27465930 Show fit	38.67	ENSRNOT00000003314	Serpinb10 NCBI RGD Ensembl Show fit	serpin family B member 10
chr5_+_149056078 Show fit	37.56	ENSRNOT00000083028	Laptm5 NCBI RGD Ensembl Show fit	lysosomal protein transmembrane 5
chr13_+_26903052 Show fit	37.03	ENSRNOT00000003625	Serpinb5 NCBI RGD Ensembl Show fit	serpin family B member 5
chr19_+_19395655 Show fit	36.20	ENSRNOT00000019130	Snx20 NCBI RGD Ensembl Show fit	sorting nexin 20

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	69.6	GO:0006342	chromatin silencing(GO:0006342)
5.6	50.8	GO:0070543	response to linoleic acid(GO:0070543)
1.3	47.5	GO:0007080	mitotic metaphase plate congression(GO:0007080)
7.4	44.6	GO:0002729	positive regulation of natural killer cell cytokine production(GO:0002729)
1.6	42.9	GO:0006471	protein ADP-ribosylation(GO:0006471)
10.2	40.9	GO:1900625	regulation of monocyte aggregation(GO:1900623) positive regulation of monocyte aggregation(GO:1900625)
0.7	39.9	GO:0007019	microtubule depolymerization(GO:0007019)
0.9	37.0	GO:0060512	prostate gland morphogenesis(GO:0060512)
2.2	35.3	GO:0016540	protein autoprocessing(GO:0016540)
3.9	34.9	GO:0046642	negative regulation of alpha-beta T cell proliferation(GO:0046642)

Showing 1 to 10 of 166 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	145.1	GO:0009897	external side of plasma membrane(GO:0009897)
1.4	141.8	GO:0000786	nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.2	98.5	GO:0000323	lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1	69.5	GO:0005615	extracellular space(GO:0005615)
0.9	51.6	GO:0005881	cytoplasmic microtubule(GO:0005881)
0.8	47.5	GO:0005871	kinesin complex(GO:0005871)
13.6	40.9	GO:0035692	macrophage migration inhibitory factor receptor complex(GO:0035692)
0.5	38.9	GO:0031901	early endosome membrane(GO:0031901)
6.5	32.6	GO:0031262	Ndc80 complex(GO:0031262)
0.3	29.1	GO:0000784	nuclear chromosome, telomeric region(GO:0000784)

Showing 1 to 10 of 72 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	116.0	GO:0046982	protein heterodimerization activity(GO:0046982)
0.8	97.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.7	61.8	GO:0003777	microtubule motor activity(GO:0003777)
2.2	50.8	GO:0051861	glycolipid binding(GO:0051861)
0.4	48.3	GO:0031490	chromatin DNA binding(GO:0031490)
0.1	45.9	GO:0005525	GTP binding(GO:0005525)
5.7	45.6	GO:0003956	NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
4.2	41.7	GO:0005114	type II transforming growth factor beta receptor binding(GO:0005114)
0.2	37.6	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.4	35.3	GO:0004190	aspartic-type endopeptidase activity(GO:0004190)

Showing 1 to 10 of 117 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.1	91.7	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.3	81.9	PID TAP63 PATHWAY	Validated transcriptional targets of TAp63 isoforms
0.3	67.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	54.7	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7	52.3	PID BCR 5PATHWAY	BCR signaling pathway
0.1	33.8	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.4	23.0	PID RHOA REG PATHWAY	Regulation of RhoA activity
0.7	22.5	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	20.7	PID ARF6 PATHWAY	Arf6 signaling events
0.8	20.1	PID IL27 PATHWAY	IL27-mediated signaling events

Showing 1 to 10 of 31 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	56.9	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.5	47.5	REACTOME KINESINS	Genes involved in Kinesins
3.2	41.9	REACTOME HYALURONAN UPTAKE AND DEGRADATION	Genes involved in Hyaluronan uptake and degradation
2.6	38.6	REACTOME IL 7 SIGNALING	Genes involved in Interleukin-7 signaling
1.5	37.8	REACTOME RNA POL I PROMOTER OPENING	Genes involved in RNA Polymerase I Promoter Opening
0.4	32.6	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase
0.7	26.6	REACTOME COSTIMULATION BY THE CD28 FAMILY	Genes involved in Costimulation by the CD28 family
1.3	23.4	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
0.2	23.2	REACTOME G ALPHA I SIGNALLING EVENTS	Genes involved in G alpha (i) signalling events
0.7	22.5	REACTOME G1 PHASE	Genes involved in G1 Phase

Showing 1 to 10 of 50 entries

Results for Trp53

Z-value: 1.30

Motif logo

Transcription factors associated with Trp53

Activity-expression correlation:

Activity profile of Trp53 motif

Sorted Z-values of Trp53 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Trp53

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: