ISMARA results: Tlx1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tlx1

Z-value: 0.82

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Transcription factors associated with Tlx1

Gene Symbol	Gene ID	Gene Info
Tlx1 NCBI RGD Ensembl	ENSRNOG00000016120	T-cell leukemia, homeobox 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tlx1	rn6_v1_chr1_+_264893162_264893162	-0.73	5.4e-55	Click!

Activity profile of Tlx1 motif

Sorted Z-values of Tlx1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_-_85386231 Show fit	45.16	ENSRNOT00000015316	Inmt NCBI RGD Ensembl Show fit	indolethylamine N-methyltransferase
chr13_-_80738634 Show fit	26.05	ENSRNOT00000081551	Fmo1 NCBI RGD Ensembl Show fit	flavin containing monooxygenase 1
chr5_-_134526089 Show fit	25.84	ENSRNOT00000013321	Cyp4b1 NCBI RGD Ensembl Show fit	cytochrome P450, family 4, subfamily b, polypeptide 1
chr13_+_113692131 Show fit	23.78	ENSRNOT00000057160	Cd34 NCBI RGD Ensembl Show fit	CD34 molecule
chr16_-_74122889 Show fit	22.56	ENSRNOT00000025763	Plat NCBI RGD Ensembl Show fit	plasminogen activator, tissue type
chr13_+_113691932 Show fit	20.43	ENSRNOT00000084709	Cd34 NCBI RGD Ensembl Show fit	CD34 molecule
chr1_-_162385575 Show fit	19.58	ENSRNOT00000016540	Thrsp NCBI RGD Ensembl Show fit	thyroid hormone responsive
chr18_+_68408890 Show fit	16.66	ENSRNOT00000039702	Ccdc68 NCBI RGD Ensembl Show fit	coiled-coil domain containing 68
chr12_-_6740714 Show fit	16.07	ENSRNOT00000001205	Medag NCBI RGD Ensembl Show fit	mesenteric estrogen-dependent adipogenesis
chr2_-_26011429 Show fit	14.75	ENSRNOT00000065143	Arhgef28 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 28

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
14.7	44.2	GO:1901258	mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
0.2	33.9	GO:0009308	amine metabolic process(GO:0009308)
2.6	26.0	GO:0070995	NADPH oxidation(GO:0070995)
3.7	25.8	GO:0018879	biphenyl metabolic process(GO:0018879)
1.7	24.1	GO:0070257	positive regulation of mucus secretion(GO:0070257)
5.6	22.6	GO:0060279	positive regulation of ovulation(GO:0060279)
0.7	19.6	GO:0010866	regulation of triglyceride biosynthetic process(GO:0010866)
1.9	18.8	GO:0060052	neurofilament cytoskeleton organization(GO:0060052)
0.3	16.1	GO:0045600	positive regulation of fat cell differentiation(GO:0045600)
1.5	15.4	GO:0097105	presynaptic membrane assembly(GO:0097105)

Showing 1 to 10 of 149 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	46.0	GO:0031012	extracellular matrix(GO:0031012)
0.1	40.9	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	40.4	GO:0005829	cytosol(GO:0005829)
1.0	35.1	GO:0046930	pore complex(GO:0046930)
0.3	33.3	GO:0048770	melanosome(GO:0042470) pigment granule(GO:0048770)
0.1	18.9	GO:0005743	mitochondrial inner membrane(GO:0005743)
0.0	18.0	GO:0005739	mitochondrion(GO:0005739)
0.2	17.0	GO:0005604	basement membrane(GO:0005604)
1.2	13.9	GO:0044327	dendritic spine head(GO:0044327)
0.4	12.8	GO:0097440	apical dendrite(GO:0097440)

Showing 1 to 10 of 69 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.6	45.2	GO:0008172	S-methyltransferase activity(GO:0008172)
5.5	44.2	GO:0043199	sulfate binding(GO:0043199)
2.2	26.0	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.4	25.8	GO:0015643	toxic substance binding(GO:0015643)
1.8	25.4	GO:0042043	neurexin family protein binding(GO:0042043)
0.2	22.6	GO:0051219	phosphoprotein binding(GO:0051219)
0.0	22.4	GO:0008289	lipid binding(GO:0008289)
1.7	15.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
2.8	13.9	GO:0031802	type 1 metabotropic glutamate receptor binding(GO:0031798) type 5 metabotropic glutamate receptor binding(GO:0031802)
1.1	12.8	GO:0015194	L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	26.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2	24.9	PID CMYB PATHWAY	C-MYB transcription factor network
0.1	23.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.8	23.6	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.1	17.9	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.5	11.9	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.2	9.4	PID HIF1 TFPATHWAY	HIF-1-alpha transcription factor network
0.1	9.0	PID ERA GENOMIC PATHWAY	Validated nuclear estrogen receptor alpha network
0.2	8.4	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.1	8.0	PID CASPASE PATHWAY	Caspase cascade in apoptosis

Showing 1 to 10 of 29 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	48.7	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.7	36.0	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8	24.4	REACTOME BASIGIN INTERACTIONS	Genes involved in Basigin interactions
0.1	17.4	REACTOME SIGNALING BY PDGF	Genes involved in Signaling by PDGF
0.8	15.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2	14.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
0.2	13.6	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.8	12.1	REACTOME OTHER SEMAPHORIN INTERACTIONS	Genes involved in Other semaphorin interactions
0.2	9.5	REACTOME GLYCOSPHINGOLIPID METABOLISM	Genes involved in Glycosphingolipid metabolism
0.6	8.5	REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS	Genes involved in Termination of O-glycan biosynthesis

Showing 1 to 10 of 45 entries

Results for Tlx1

Z-value: 0.82

Motif logo

Transcription factors associated with Tlx1

Activity-expression correlation:

Activity profile of Tlx1 motif

Sorted Z-values of Tlx1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: