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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tlx1

Z-value: 0.82

Motif logo

Transcription factors associated with Tlx1

Gene Symbol Gene ID Gene Info
ENSRNOG00000016120 T-cell leukemia, homeobox 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tlx1rn6_v1_chr1_+_264893162_264893162-0.735.4e-55Click!

Activity profile of Tlx1 motif

Sorted Z-values of Tlx1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_85386231 45.16 ENSRNOT00000015316
indolethylamine N-methyltransferase
chr13_-_80738634 26.05 ENSRNOT00000081551
flavin containing monooxygenase 1
chr5_-_134526089 25.84 ENSRNOT00000013321
cytochrome P450, family 4, subfamily b, polypeptide 1
chr13_+_113692131 23.78 ENSRNOT00000057160
CD34 molecule
chr16_-_74122889 22.56 ENSRNOT00000025763
plasminogen activator, tissue type
chr13_+_113691932 20.43 ENSRNOT00000084709
CD34 molecule
chr1_-_162385575 19.58 ENSRNOT00000016540
thyroid hormone responsive
chr18_+_68408890 16.66 ENSRNOT00000039702
coiled-coil domain containing 68
chr12_-_6740714 16.07 ENSRNOT00000001205
mesenteric estrogen-dependent adipogenesis
chr2_-_26011429 14.75 ENSRNOT00000065143
Rho guanine nucleotide exchange factor 28
chr5_-_93244202 14.12 ENSRNOT00000075474
protein tyrosine phosphatase, receptor type, D
chr13_-_80379929 13.93 ENSRNOT00000067653
ENSRNOT00000075938
dynamin 3
chr4_-_147163467 13.23 ENSRNOT00000010748
tissue inhibitor of metalloproteinase 4
chr1_+_91433030 12.78 ENSRNOT00000015205
solute carrier family 7 member 10
chr1_+_154579949 12.58 ENSRNOT00000045048
synaptotagmin-like 2
chr10_+_84147836 12.27 ENSRNOT00000010527
homeo box B6
chr4_-_17594598 12.11 ENSRNOT00000008936
semaphorin 3E
chr1_-_261986759 11.91 ENSRNOT00000021257
pyridine nucleotide-disulphide oxidoreductase domain 2
chr5_-_147412705 11.63 ENSRNOT00000010688
similar to mKIAA1522 protein
chr1_-_156354353 11.55 ENSRNOT00000042163
synaptotagmin-like 2
chr6_-_137084739 11.23 ENSRNOT00000060943
transmembrane protein 179
chr5_-_101166651 11.14 ENSRNOT00000078862
Fras1 related extracellular matrix 1
chr1_-_100669684 11.11 ENSRNOT00000091760
myosin heavy chain 14
chr4_+_62019970 11.04 ENSRNOT00000013133
aldose reductase-related protein 1-like
chr20_-_9855443 10.82 ENSRNOT00000090275
ENSRNOT00000066266
trefoil factor 3
chr13_+_47454591 10.22 ENSRNOT00000005791
similar to specifically androgen-regulated protein
chr3_+_149668102 10.03 ENSRNOT00000055342
BPI fold containing family B, member 1
chr14_+_84306466 10.00 ENSRNOT00000006116
SEC14-like lipid binding 4
chr7_+_143749221 9.70 ENSRNOT00000014807
insulin-like growth factor binding protein 6
chr2_-_195908037 9.64 ENSRNOT00000079776
tuftelin 1
chr3_-_160853650 9.41 ENSRNOT00000018844
matrilin 4
chr16_+_6078122 9.24 ENSRNOT00000021407
choline dehydrogenase
chr13_+_112031594 9.09 ENSRNOT00000008440
laminin subunit beta 3
chr3_+_35271786 8.92 ENSRNOT00000065989
LY6/PLAUR domain containing 6B
chr3_-_175601127 8.83 ENSRNOT00000081226
laminin subunit alpha 5
chr2_-_195888216 8.76 ENSRNOT00000056436
tuftelin 1
chr3_-_110556808 8.75 ENSRNOT00000092158
ENSRNOT00000045362
similar to hypothetical protein
chr20_+_5008508 8.67 ENSRNOT00000001153
von Willebrand factor A domain containing 7
chr1_+_214778496 8.53 ENSRNOT00000028967
mucin 5B, oligomeric mucus/gel-forming
chr3_-_105512939 8.50 ENSRNOT00000011773
actin, alpha, cardiac muscle 1
chr18_-_58499836 8.46 ENSRNOT00000065693
piezo-type mechanosensitive ion channel component 2
chr7_-_143016040 8.35 ENSRNOT00000029697
keratin 80
chr4_-_117111653 8.34 ENSRNOT00000057537
sideroflexin 5
chr4_-_114853868 8.26 ENSRNOT00000090828
WD repeat domain 54
chr3_+_112428395 8.19 ENSRNOT00000079109
ENSRNOT00000048141
StAR-related lipid transfer domain containing 9
chr6_+_119519714 8.10 ENSRNOT00000004955
fibronectin leucine rich transmembrane protein 2
chr5_-_6083083 7.84 ENSRNOT00000072411
sulfatase 1
chr16_+_54291251 7.65 ENSRNOT00000079006
microtubule associated tumor suppressor 1
chr5_-_126395668 7.62 ENSRNOT00000010396
acyl-CoA thioesterase 11
chr2_+_95320283 7.47 ENSRNOT00000015537
hes-related family bHLH transcription factor with YRPW motif 1
chr14_+_84237520 7.43 ENSRNOT00000083580
galactose-3-O-sulfotransferase 1
chr4_-_82177420 7.41 ENSRNOT00000074452
homeobox protein Hox-A6-like
chr20_-_13142856 7.38 ENSRNOT00000001743
S100 calcium binding protein B
chr3_+_110975923 7.38 ENSRNOT00000016458
GTP cyclohydrolase I feedback regulator
chr4_+_85662892 7.14 ENSRNOT00000016175
ENSRNOT00000043851
ENSRNOT00000035722
ENSRNOT00000046192
adenylate cyclase activating polypeptide 1 receptor type 1
chr8_+_116776494 7.08 ENSRNOT00000050702
cadherin-related family member 4
chr8_+_115150514 7.05 ENSRNOT00000016504
abhydrolase domain containing 14b
chr16_-_64806050 7.05 ENSRNOT00000015725
dual specificity phosphatase 26
chr4_-_82263117 7.04 ENSRNOT00000008542
homeobox protein Hox-A6-like
chr2_-_154418920 6.99 ENSRNOT00000076326
phospholipase C, eta 1
chr3_-_138462063 6.86 ENSRNOT00000065553
ovo-like zinc finger 2
chr10_+_13736313 6.84 ENSRNOT00000079700
ATP binding cassette subfamily A member 3
chr10_+_56381813 6.72 ENSRNOT00000019687
zinc finger and BTB domain containing 4
chr14_-_103321270 6.68 ENSRNOT00000006157
Meis homeobox 1
chr17_+_47721977 6.57 ENSRNOT00000080800
amphiphysin-like
chr3_-_2689084 6.50 ENSRNOT00000020926
prostaglandin D2 synthase
chr19_-_56677084 6.48 ENSRNOT00000024084
actin, alpha 1, skeletal muscle
chr4_+_44597123 6.45 ENSRNOT00000078250
caveolin 1
chr8_-_115140080 6.45 ENSRNOT00000015851
aminoacylase 1
chr1_+_201055644 6.36 ENSRNOT00000054937
ENSRNOT00000047161
transforming, acidic coiled-coil containing protein 2
chr5_-_126911520 6.22 ENSRNOT00000091521
deiodinase, iodothyronine, type I
chr19_+_23389375 6.21 ENSRNOT00000018629
spalt-like transcription factor 1
chr13_+_44424689 6.14 ENSRNOT00000005206
aminocarboxymuconate semialdehyde decarboxylase
chrX_+_110818716 6.10 ENSRNOT00000086308
ring finger protein 128, E3 ubiquitin protein ligase
chr7_-_11001933 6.09 ENSRNOT00000084006
transducin-like enhancer of split 2
chr6_+_107245820 5.89 ENSRNOT00000012757
papilin, proteoglycan-like sulfated glycoprotein
chr1_-_221281180 5.80 ENSRNOT00000028379
CDC42 effector protein 2
chr17_-_14627937 5.66 ENSRNOT00000020532
osteoglycin
chr17_-_88037034 5.65 ENSRNOT00000080193
ENSRNOT00000034907
phosphoribosyl transferase domain containing 1
chr17_+_5513930 5.56 ENSRNOT00000091370
ATP/GTP binding protein 1
chr4_-_52350624 5.56 ENSRNOT00000060476
transmembrane protein 229A
chr4_+_144382945 5.42 ENSRNOT00000007601
caveolin 3
chr10_+_86950557 5.31 ENSRNOT00000014153
insulin-like growth factor binding protein 4
chr19_+_10563423 5.28 ENSRNOT00000021037
docking protein 4
chr3_-_3574787 5.24 ENSRNOT00000087651
NACC family member 2
chr3_+_11629556 5.21 ENSRNOT00000074401
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 6
chrX_+_156909913 5.19 ENSRNOT00000084390
L1 cell adhesion molecule
chr2_-_102871257 5.16 ENSRNOT00000013116
cytochrome P450, family 7, subfamily b, polypeptide 1
chr1_+_83653234 5.15 ENSRNOT00000085008
ENSRNOT00000084230
ENSRNOT00000090071
cytochrome P450, family 2, subfamily a, polypeptide 1
chr2_-_210726179 5.14 ENSRNOT00000025689
glutathione S-transferase, mu 7
chr2_+_226900619 5.13 ENSRNOT00000019638
phosphodiesterase 5A
chr4_+_147692028 5.07 ENSRNOT00000014207
cullin-associated and neddylation-dissociated 2 (putative)
chr19_-_15421404 5.04 ENSRNOT00000083684
solute carrier family 6 member 2
chrX_+_68771100 4.99 ENSRNOT00000043872
StAR-related lipid transfer domain containing 8
chr4_+_31534225 4.88 ENSRNOT00000089292
ENSRNOT00000016423
collagen, type I, alpha 2
chr4_+_7355574 4.78 ENSRNOT00000013800
potassium voltage-gated channel subfamily H member 2
chr3_+_122836446 4.65 ENSRNOT00000028816
early B-cell factor 4
chr20_-_28814636 4.61 ENSRNOT00000086030
septin 10
chr3_+_145032200 4.54 ENSRNOT00000068210
synapse differentiation inducing 1
chr5_+_76812931 4.51 ENSRNOT00000059458
hydroxysteroid dehydrogenase like 2
chr8_+_85355766 4.50 ENSRNOT00000010583
glial cells missing homolog 1
chr7_+_119647375 4.40 ENSRNOT00000046563
potassium channel tetramerization domain containing 17
chr4_+_66090681 4.38 ENSRNOT00000078066
tetratricopeptide repeat domain 26
chr17_+_80882666 4.36 ENSRNOT00000024430
vimentin
chr13_-_100672731 4.25 ENSRNOT00000004319
delta(4)-desaturase, sphingolipid 1
chr2_-_154508877 4.24 ENSRNOT00000086472
similar to hypothetical protein E130311K13
chr19_-_10596851 4.20 ENSRNOT00000021716
coenzyme Q9
chr12_+_41543696 4.08 ENSRNOT00000079639
two pore segment channel 1
chr2_+_93792601 4.07 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr10_-_85084850 4.04 ENSRNOT00000012462
TBK1 binding protein 1
chr7_+_142575672 3.98 ENSRNOT00000080923
ENSRNOT00000008160
sodium voltage-gated channel alpha subunit 8
chr4_+_7377563 3.93 ENSRNOT00000084826
potassium voltage-gated channel subfamily H member 2
chr16_-_6404578 3.89 ENSRNOT00000051371
calcium voltage-gated channel subunit alpha1 D
chr2_-_187622373 3.89 ENSRNOT00000026396
Rh family B glycoprotein
chr2_+_184600721 3.85 ENSRNOT00000075823
glutamyl-tRNA amidotransferase subunit B
chr1_+_221099998 3.84 ENSRNOT00000028262
latent transforming growth factor beta binding protein 3
chr10_+_65586504 3.82 ENSRNOT00000015535
ENSRNOT00000046388
aldolase, fructose-bisphosphate C
chr20_-_20680675 3.80 ENSRNOT00000087085
Rho-related BTB domain containing 1
chr20_+_28815039 3.76 ENSRNOT00000075800
sosondowah ankyrin repeat domain family member C
chrX_-_82743753 3.72 ENSRNOT00000003512
ribosomal protein S6 kinase A6
chr8_-_60830448 3.65 ENSRNOT00000022419
tetraspanin 3
chr13_+_79378733 3.59 ENSRNOT00000039221
tumor necrosis factor superfamily member 18
chr1_-_49844547 3.58 ENSRNOT00000086127
ENSRNOT00000077423
ENSRNOT00000089439
ENSRNOT00000090521

chr10_+_57322331 3.57 ENSRNOT00000041493
kinesin family member 1C
chr10_-_70646495 3.56 ENSRNOT00000071218
growth arrest-specific 2 like 2
chr15_-_27815261 3.54 ENSRNOT00000032992
kelch-like family member 33
chr18_+_79406381 3.49 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr1_-_212021567 3.47 ENSRNOT00000029027
cilia and flagella associated protein 46
chr14_-_8510138 3.33 ENSRNOT00000080758
Rho GTPase activating protein 24
chr19_+_61332351 3.26 ENSRNOT00000014492
neuropilin 1
chr3_+_109862117 3.23 ENSRNOT00000083351
ENSRNOT00000070912
thrombospondin 1
chr5_-_172424081 3.15 ENSRNOT00000019096
phospholipase C, eta 2
chr19_+_43163562 3.10 ENSRNOT00000048900
C-type lectin domain family 18, member A
chr14_+_83724933 3.08 ENSRNOT00000029848
phospholipase A2, group III
chr6_-_62798384 3.01 ENSRNOT00000093200
NADH dehydrogenase (ubiquinone) 1 alpha subcomplex 10-like 1
chr12_-_37538403 3.00 ENSRNOT00000001402
small nuclear ribonucleoprotein U11/U12 subunit 35
chr1_-_198104109 2.99 ENSRNOT00000026186
sulfotransferase family 1A member 1
chr16_+_11599753 2.98 ENSRNOT00000079833
glutamate ionotropic receptor delta type subunit 1
chr19_+_43163129 2.93 ENSRNOT00000073721
C-type lectin domain family 18, member A
chr1_+_135083974 2.89 ENSRNOT00000016481
ENSRNOT00000076098
family with sequence similarity 174, member B
chr12_+_40553741 2.87 ENSRNOT00000057396
rCG21419-like
chr13_-_72890841 2.82 ENSRNOT00000093726
similar to 6820428L09 protein
chr1_-_184188911 2.80 ENSRNOT00000055124
ENSRNOT00000014948
calcitonin-related polypeptide alpha
chr7_-_144993652 2.77 ENSRNOT00000087748
integrin subunit alpha 5
chr13_+_42220251 2.67 ENSRNOT00000078185

chr4_-_117767772 2.66 ENSRNOT00000084170
probable N-acetyltransferase CML1
chrX_-_10218583 2.65 ENSRNOT00000013382
nyctalopin
chr1_-_101351879 2.63 ENSRNOT00000028142
PTPRF interacting protein alpha 3
chr4_+_78233332 2.60 ENSRNOT00000011032
replication initiator 1
chr1_+_184299250 2.59 ENSRNOT00000030540
inscuteable homolog (Drosophila)
chr14_-_89208813 2.57 ENSRNOT00000091671
ENSRNOT00000006852
HUS1 checkpoint clamp component
chr1_+_91152635 2.57 ENSRNOT00000073438
dermokine-like
chr4_-_82263302 2.54 ENSRNOT00000082933
homeobox protein Hox-A6-like
chr11_+_31002451 2.53 ENSRNOT00000002838
eva-1 homolog C
chr7_-_119441487 2.52 ENSRNOT00000067635
parvalbumin
chr17_-_54714914 2.52 ENSRNOT00000024336
zinc finger E-box binding homeobox 1
chr20_+_1749716 2.52 ENSRNOT00000048856
olfactory receptor 1735
chr10_-_107376645 2.48 ENSRNOT00000046213
CEP295 N-terminal like
chr1_+_257076221 2.43 ENSRNOT00000044895
solute carrier family 35, member G1
chr1_-_219144610 2.42 ENSRNOT00000023526
NADH:ubiquinone oxidoreductase core subunit S8
chr10_-_74376270 2.41 ENSRNOT00000079311
glycerophosphodiester phosphodiesterase domain containing 1
chr4_+_145342193 2.39 ENSRNOT00000012015
tubulin tyrosine ligase like 3
chr8_-_21995806 2.38 ENSRNOT00000028034
sphingosine-1-phosphate receptor 2
chr17_-_61332391 2.33 ENSRNOT00000034599
SNRPN upstream reading frame protein-like
chr5_-_131860637 2.31 ENSRNOT00000064569
ENSRNOT00000080242
solute carrier family 5 member 9
chr10_-_56289882 2.25 ENSRNOT00000090762
ENSRNOT00000056903
tumor necrosis factor superfamily member 13
chr12_-_51250230 2.24 ENSRNOT00000029508
meningioma 1
chr19_+_56026106 2.18 ENSRNOT00000066552
cyclin-dependent kinase 10
chr14_+_46001849 2.13 ENSRNOT00000076611
RELT-like 1
chr1_-_71399751 2.12 ENSRNOT00000020787
zinc finger protein 444
chr11_+_30363280 2.12 ENSRNOT00000002885
superoxide dismutase 1, soluble
chr6_-_77421286 2.06 ENSRNOT00000011453
NK2 homeobox 1
chr1_+_170383682 2.02 ENSRNOT00000024224
sphingomyelin phosphodiesterase 1
chrX_+_122724129 2.00 ENSRNOT00000017746
interleukin 13 receptor, alpha 1-like
chr6_+_127941526 1.97 ENSRNOT00000033897
Ab1-233
chr8_+_85413537 1.96 ENSRNOT00000078159
intestinal cell kinase
chr1_+_266781617 1.94 ENSRNOT00000027417
internexin neuronal intermediate filament protein, alpha
chr9_+_46996156 1.91 ENSRNOT00000019673
interleukin 1 receptor type 1
chr11_+_69484293 1.90 ENSRNOT00000049292
kalirin, RhoGEF kinase
chr4_-_117575154 1.88 ENSRNOT00000075813
probable N-acetyltransferase CML2-like
chr7_+_116357783 1.86 ENSRNOT00000076279
lymphocyte antigen 6 complex, locus E
chr2_+_198726118 1.83 ENSRNOT00000056237
limb and CNS expressed 1 like
chrX_+_29525256 1.75 ENSRNOT00000050018
RAB9A, member RAS oncogene family
chr7_-_123088819 1.74 ENSRNOT00000056077

chr20_+_27954433 1.73 ENSRNOT00000064288
LIM zinc finger domain containing 1
chr1_+_215214853 1.69 ENSRNOT00000071235
ENSRNOT00000080442
SH3 and multiple ankyrin repeat domains protein 2-like
chr5_+_137546860 1.63 ENSRNOT00000074431
olfactory receptor 858
chr5_-_173098816 1.62 ENSRNOT00000023696
mindbomb E3 ubiquitin protein ligase 2
chr5_+_140888973 1.61 ENSRNOT00000020524
5'-nucleotidase, cytosolic IA
chr8_-_22542997 1.58 ENSRNOT00000061009
transmembrane p24 trafficking protein 1
chr9_+_82596355 1.57 ENSRNOT00000065076
SPEG complex locus
chr1_-_175796040 1.56 ENSRNOT00000024060
murine retrovirus integration site 1 homolog
chr1_-_100530183 1.55 ENSRNOT00000067754
myosin binding protein C, fast-type
chr1_-_89543967 1.48 ENSRNOT00000079631
hepsin
chr17_+_85364483 1.44 ENSRNOT00000064257
BMI1 proto-oncogene, polycomb ring finger
chr13_-_90832469 1.42 ENSRNOT00000086508
immunoglobulin superfamily, member 9
chr9_-_82008620 1.41 ENSRNOT00000023365
protein kinase AMP-activated non-catalytic subunit gamma 3
chr5_-_171459488 1.37 ENSRNOT00000075423
ENSRNOT00000080686
tumor protein p63 regulated 1-like
chr3_+_3788583 1.33 ENSRNOT00000084567
G-protein signaling modulator 1
chr10_+_14727180 1.32 ENSRNOT00000025236
tryptase gamma 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tlx1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.7 44.2 GO:1901258 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
5.6 22.6 GO:0060279 positive regulation of ovulation(GO:0060279)
3.7 15.0 GO:0030240 skeletal muscle thin filament assembly(GO:0030240)
3.7 25.8 GO:0018879 biphenyl metabolic process(GO:0018879)
2.9 8.7 GO:1902303 negative regulation of potassium ion export(GO:1902303)
2.6 7.8 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
2.6 26.0 GO:0070995 NADPH oxidation(GO:0070995)
2.5 7.5 GO:2000820 negative regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000820)
2.5 7.4 GO:0019375 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
2.3 13.9 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
2.3 6.9 GO:0060214 endocardium formation(GO:0060214)
2.1 6.4 GO:2000286 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) regulation of inward rectifier potassium channel activity(GO:1901979) positive regulation of gap junction assembly(GO:1903598) receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
2.1 8.3 GO:0015746 citrate transport(GO:0015746)
2.1 6.2 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
1.9 5.6 GO:0046038 guanine salvage(GO:0006178) GMP catabolic process(GO:0046038) guanine biosynthetic process(GO:0046099)
1.9 18.8 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
1.8 12.8 GO:0042940 D-amino acid transport(GO:0042940)
1.8 5.4 GO:0035995 detection of muscle stretch(GO:0035995)
1.8 14.1 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
1.7 24.1 GO:0070257 positive regulation of mucus secretion(GO:0070257)
1.7 5.1 GO:1902310 positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
1.7 5.1 GO:0010265 SCF complex assembly(GO:0010265)
1.6 6.5 GO:2000255 negative regulation of male germ cell proliferation(GO:2000255)
1.5 15.4 GO:0097105 presynaptic membrane assembly(GO:0097105)
1.4 8.1 GO:0061343 cell adhesion involved in heart morphogenesis(GO:0061343)
1.3 5.2 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
1.3 3.9 GO:0070634 transepithelial ammonium transport(GO:0070634)
1.3 3.9 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
1.3 5.1 GO:0055118 negative regulation of cardiac muscle contraction(GO:0055118)
1.3 3.8 GO:1902460 regulation of mesenchymal stem cell proliferation(GO:1902460) positive regulation of mesenchymal stem cell proliferation(GO:1902462)
1.2 3.6 GO:2000328 regulation of T-helper 17 cell lineage commitment(GO:2000328)
1.2 3.5 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
1.2 9.2 GO:0006578 amino-acid betaine biosynthetic process(GO:0006578)
1.1 4.4 GO:1900147 Schwann cell migration(GO:0036135) regulation of Schwann cell migration(GO:1900147)
1.1 3.3 GO:0021649 vestibulocochlear nerve structural organization(GO:0021649) neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) renal artery morphogenesis(GO:0061441) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
1.1 3.2 GO:0010752 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of cGMP-mediated signaling(GO:0010752)
1.1 7.4 GO:2001015 negative regulation of skeletal muscle cell differentiation(GO:2001015)
1.0 5.2 GO:0001574 ganglioside biosynthetic process(GO:0001574)
1.0 6.1 GO:0046874 quinolinate metabolic process(GO:0046874)
1.0 10.0 GO:0034144 negative regulation of toll-like receptor 4 signaling pathway(GO:0034144)
0.9 2.8 GO:0001983 baroreceptor response to increased systemic arterial blood pressure(GO:0001983)
0.9 5.6 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
0.9 4.5 GO:0060018 astrocyte fate commitment(GO:0060018)
0.8 2.4 GO:0018094 protein polyglycylation(GO:0018094)
0.8 2.3 GO:0002426 immunoglobulin production in mucosal tissue(GO:0002426)
0.7 5.2 GO:0035754 B cell chemotaxis(GO:0035754)
0.7 5.2 GO:0009804 coumarin metabolic process(GO:0009804)
0.7 19.6 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.6 2.6 GO:0044778 meiotic DNA integrity checkpoint(GO:0044778)
0.6 2.6 GO:1903575 cornified envelope assembly(GO:1903575)
0.6 1.9 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
0.6 7.1 GO:0060732 positive regulation of inositol phosphate biosynthetic process(GO:0060732)
0.6 11.1 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.6 15.0 GO:0043567 regulation of insulin-like growth factor receptor signaling pathway(GO:0043567)
0.6 1.1 GO:0043382 positive regulation of memory T cell differentiation(GO:0043382)
0.5 4.5 GO:0097091 synaptic vesicle clustering(GO:0097091)
0.5 2.0 GO:0035772 interleukin-13-mediated signaling pathway(GO:0035772)
0.5 3.0 GO:0009812 flavonoid metabolic process(GO:0009812)
0.5 1.5 GO:0034769 basement membrane disassembly(GO:0034769) pilomotor reflex(GO:0097195)
0.5 2.0 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.5 5.8 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.5 1.9 GO:0098989 NMDA selective glutamate receptor signaling pathway(GO:0098989)
0.4 11.1 GO:0071625 vocalization behavior(GO:0071625)
0.4 3.9 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
0.4 6.4 GO:0030953 astral microtubule organization(GO:0030953)
0.4 1.3 GO:0046356 acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952) metanephric proximal tubule development(GO:0072237)
0.4 3.3 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.4 2.4 GO:0090394 negative regulation of excitatory postsynaptic potential(GO:0090394)
0.4 2.2 GO:0001957 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 5.0 GO:0051934 dopamine uptake involved in synaptic transmission(GO:0051583) catecholamine uptake involved in synaptic transmission(GO:0051934)
0.3 5.2 GO:1902231 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage(GO:1902231)
0.3 12.1 GO:0071526 negative regulation of cell-matrix adhesion(GO:0001953) semaphorin-plexin signaling pathway(GO:0071526)
0.3 1.0 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.3 2.1 GO:0021759 globus pallidus development(GO:0021759)
0.3 3.1 GO:0019372 lipoxygenase pathway(GO:0019372)
0.3 3.7 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.3 2.0 GO:0023021 termination of signal transduction(GO:0023021)
0.3 1.0 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.3 6.7 GO:0035855 megakaryocyte development(GO:0035855)
0.3 4.1 GO:0050872 white fat cell differentiation(GO:0050872)
0.3 2.4 GO:1990034 calcium ion export from cell(GO:1990034)
0.3 1.8 GO:0052428 negative regulation by host of symbiont molecular function(GO:0052405) modification by host of symbiont molecular function(GO:0052428)
0.3 1.7 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.3 1.4 GO:0033092 positive regulation of immature T cell proliferation in thymus(GO:0033092)
0.3 2.5 GO:0048752 semicircular canal morphogenesis(GO:0048752)
0.3 13.0 GO:0035987 endodermal cell differentiation(GO:0035987)
0.3 3.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.3 4.2 GO:0006744 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.3 8.8 GO:0001755 neural crest cell migration(GO:0001755)
0.3 16.1 GO:0045600 positive regulation of fat cell differentiation(GO:0045600)
0.3 8.5 GO:0043030 regulation of macrophage activation(GO:0043030)
0.2 33.9 GO:0009308 amine metabolic process(GO:0009308)
0.2 4.7 GO:0010758 regulation of macrophage chemotaxis(GO:0010758)
0.2 1.1 GO:0061589 calcium activated phosphatidylserine scrambling(GO:0061589)
0.2 1.5 GO:0060087 relaxation of vascular smooth muscle(GO:0060087)
0.2 1.6 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128)
0.2 0.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.2 8.5 GO:0050974 detection of mechanical stimulus involved in sensory perception(GO:0050974)
0.2 8.1 GO:0086010 membrane depolarization during action potential(GO:0086010)
0.2 0.7 GO:0051958 methotrexate transport(GO:0051958)
0.2 4.3 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.2 4.4 GO:0045724 positive regulation of cilium assembly(GO:0045724)
0.2 2.6 GO:2001273 regulation of glucose import in response to insulin stimulus(GO:2001273)
0.1 0.7 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.1 4.6 GO:0042073 intraciliary transport(GO:0042073)
0.1 1.9 GO:0042415 norepinephrine metabolic process(GO:0042415)
0.1 1.3 GO:0044351 macropinocytosis(GO:0044351)
0.1 12.3 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.1 3.0 GO:0035235 ionotropic glutamate receptor signaling pathway(GO:0035235)
0.1 1.0 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
0.1 6.2 GO:0042446 hormone biosynthetic process(GO:0042446)
0.1 2.4 GO:0032981 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 2.6 GO:0048172 regulation of short-term neuronal synaptic plasticity(GO:0048172)
0.1 0.6 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 5.7 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 3.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.1 9.4 GO:0048678 response to axon injury(GO:0048678)
0.1 5.4 GO:0070373 negative regulation of ERK1 and ERK2 cascade(GO:0070373)
0.1 3.6 GO:0046426 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1 3.1 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.1 10.8 GO:0007586 digestion(GO:0007586)
0.1 1.1 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 2.6 GO:0060479 lung cell differentiation(GO:0060479) lung epithelial cell differentiation(GO:0060487)
0.1 6.1 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 1.3 GO:0034453 microtubule anchoring(GO:0034453)
0.1 7.9 GO:0051225 spindle assembly(GO:0051225)
0.1 1.0 GO:0060396 growth hormone receptor signaling pathway(GO:0060396)
0.1 0.7 GO:0046325 negative regulation of glucose import(GO:0046325)
0.1 1.8 GO:0097352 autophagosome maturation(GO:0097352)
0.1 1.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 0.2 GO:0042908 xenobiotic transport(GO:0042908)
0.0 5.4 GO:0048015 phosphatidylinositol-mediated signaling(GO:0048015)
0.0 0.2 GO:0060014 granulosa cell differentiation(GO:0060014)
0.0 0.8 GO:0071539 protein localization to centrosome(GO:0071539)
0.0 1.4 GO:0009250 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.0 3.6 GO:0001578 microtubule bundle formation(GO:0001578)
0.0 0.1 GO:0009597 detection of virus(GO:0009597)
0.0 4.6 GO:0051291 protein heterooligomerization(GO:0051291)
0.0 0.1 GO:0006529 asparagine biosynthetic process(GO:0006529)
0.0 0.1 GO:0098749 cerebellar neuron development(GO:0098749)
0.0 1.6 GO:0055013 cardiac muscle cell development(GO:0055013)
0.0 0.3 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
0.0 1.0 GO:0031023 microtubule organizing center organization(GO:0031023)
0.0 0.1 GO:0070127 tRNA aminoacylation for mitochondrial protein translation(GO:0070127)
0.0 1.4 GO:0050807 regulation of synapse organization(GO:0050807)
0.0 0.5 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 1.3 GO:0007605 sensory perception of sound(GO:0007605)
0.0 1.6 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 11.1 GO:0097513 myosin II filament(GO:0097513)
2.3 6.8 GO:0097233 lamellar body membrane(GO:0097232) alveolar lamellar body membrane(GO:0097233)
2.2 8.8 GO:0043259 laminin-10 complex(GO:0043259)
1.4 9.7 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
1.3 3.9 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
1.2 13.9 GO:0044327 dendritic spine head(GO:0044327)
1.1 9.1 GO:0005610 laminin-5 complex(GO:0005610)
1.0 35.1 GO:0046930 pore complex(GO:0046930)
0.9 4.4 GO:0045098 type III intermediate filament(GO:0045098)
0.7 6.4 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.6 3.5 GO:0033269 internode region of axon(GO:0033269)
0.5 5.2 GO:0044294 dendritic growth cone(GO:0044294)
0.4 2.6 GO:0030896 checkpoint clamp complex(GO:0030896)
0.4 3.3 GO:0097443 sorting endosome(GO:0097443)
0.4 3.2 GO:0005577 fibrinogen complex(GO:0005577)
0.4 3.9 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
0.4 12.8 GO:0097440 apical dendrite(GO:0097440)
0.4 3.0 GO:0000243 commitment complex(GO:0000243)
0.4 8.4 GO:0030057 desmosome(GO:0030057)
0.3 3.9 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.3 33.3 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.3 6.2 GO:0010369 chromocenter(GO:0010369)
0.3 5.4 GO:0090665 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.3 6.5 GO:0005865 striated muscle thin filament(GO:0005865)
0.2 2.0 GO:0097542 ciliary tip(GO:0097542)
0.2 4.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 4.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.2 1.2 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 17.0 GO:0005604 basement membrane(GO:0005604)
0.1 1.9 GO:0005883 neurofilament(GO:0005883)
0.1 2.0 GO:0042599 lamellar body(GO:0042599)
0.1 2.1 GO:0031045 dense core granule(GO:0031045)
0.1 1.1 GO:0030314 junctional membrane complex(GO:0030314)
0.1 7.4 GO:0001726 ruffle(GO:0001726)
0.1 3.1 GO:0042629 mast cell granule(GO:0042629)
0.1 3.5 GO:0034451 centriolar satellite(GO:0034451)
0.1 46.0 GO:0031012 extracellular matrix(GO:0031012)
0.1 2.8 GO:0008305 integrin complex(GO:0008305)
0.1 1.4 GO:0035102 PRC1 complex(GO:0035102)
0.1 5.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 6.7 GO:0042641 actomyosin(GO:0042641)
0.1 2.7 GO:0060077 inhibitory synapse(GO:0060077)
0.1 2.6 GO:0048786 presynaptic active zone(GO:0048786)
0.1 6.9 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 4.5 GO:0031901 early endosome membrane(GO:0031901)
0.1 0.6 GO:0005915 zonula adherens(GO:0005915)
0.1 1.6 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.1 5.4 GO:0070469 respiratory chain(GO:0070469)
0.1 40.9 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.1 18.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 2.2 GO:0016592 mediator complex(GO:0016592)
0.0 3.8 GO:0005795 Golgi stack(GO:0005795)
0.0 5.8 GO:0005770 late endosome(GO:0005770)
0.0 4.1 GO:0010008 endosome membrane(GO:0010008)
0.0 3.6 GO:0005814 centriole(GO:0005814)
0.0 5.8 GO:0005925 focal adhesion(GO:0005925)
0.0 2.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.0 3.7 GO:0001650 fibrillar center(GO:0001650)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.0 0.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588)
0.0 1.6 GO:0014069 postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.0 2.5 GO:0031514 motile cilium(GO:0031514)
0.0 1.6 GO:0005769 early endosome(GO:0005769)
0.0 18.0 GO:0005739 mitochondrion(GO:0005739)
0.0 2.6 GO:0022626 cytosolic ribosome(GO:0022626)
0.0 3.0 GO:0045211 postsynaptic membrane(GO:0045211)
0.0 40.4 GO:0005829 cytosol(GO:0005829)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
5.6 45.2 GO:0008172 S-methyltransferase activity(GO:0008172)
5.5 44.2 GO:0043199 sulfate binding(GO:0043199)
2.8 13.9 GO:0031802 type 1 metabotropic glutamate receptor binding(GO:0031798) type 5 metabotropic glutamate receptor binding(GO:0031802)
2.6 7.8 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
2.5 7.5 GO:0035939 microsatellite binding(GO:0035939)
2.4 7.1 GO:0004999 vasoactive intestinal polypeptide receptor activity(GO:0004999)
2.3 7.0 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
2.3 6.8 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.2 26.0 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
2.1 6.4 GO:0004046 aminoacylase activity(GO:0004046)
2.1 8.3 GO:0015137 citrate transmembrane transporter activity(GO:0015137)
1.9 7.4 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733)
1.8 25.4 GO:0042043 neurexin family protein binding(GO:0042043)
1.7 5.2 GO:0008396 oxysterol 7-alpha-hydroxylase activity(GO:0008396)
1.7 15.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
1.4 4.3 GO:0042284 sphingolipid delta-4 desaturase activity(GO:0042284)
1.4 25.8 GO:0015643 toxic substance binding(GO:0015643)
1.3 3.9 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
1.3 5.0 GO:0005333 norepinephrine transmembrane transporter activity(GO:0005333)
1.2 8.7 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.1 11.9 GO:0019870 potassium channel inhibitor activity(GO:0019870)
1.1 12.8 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
1.0 5.2 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
1.0 12.4 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.0 3.0 GO:0050294 steroid sulfotransferase activity(GO:0050294) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
1.0 5.8 GO:0001515 opioid peptide activity(GO:0001515)
0.9 8.5 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.9 12.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.9 4.4 GO:1990254 keratin filament binding(GO:1990254)
0.8 7.4 GO:0050786 RAGE receptor binding(GO:0050786)
0.8 4.1 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
0.8 2.4 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.8 11.1 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.8 6.2 GO:0008430 selenium binding(GO:0008430)
0.6 3.9 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
0.6 3.2 GO:0070052 collagen V binding(GO:0070052)
0.6 1.9 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
0.6 8.1 GO:0045499 chemorepellent activity(GO:0045499)
0.5 3.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.4 1.3 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.4 2.1 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
0.4 3.3 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021) vascular endothelial growth factor binding(GO:0038085)
0.4 5.2 GO:0033691 sialic acid binding(GO:0033691)
0.4 5.1 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.4 1.4 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.3 11.5 GO:0004407 histone deacetylase activity(GO:0004407)
0.3 1.7 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.3 6.7 GO:0008327 methyl-CpG binding(GO:0008327)
0.3 3.5 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.3 2.0 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.3 4.4 GO:0097602 cullin family protein binding(GO:0097602)
0.3 6.0 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 2.4 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.2 2.3 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.2 7.1 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 7.4 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 5.6 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.2 10.6 GO:0005504 fatty acid binding(GO:0005504)
0.2 5.2 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.2 3.2 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 22.6 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 3.8 GO:0050431 transforming growth factor beta binding(GO:0050431)
0.2 0.7 GO:0015350 methotrexate transporter activity(GO:0015350)
0.2 0.5 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.2 3.9 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.2 5.3 GO:0005158 insulin receptor binding(GO:0005158)
0.1 4.0 GO:0005248 voltage-gated sodium channel activity(GO:0005248)
0.1 5.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.9 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.1 3.0 GO:0005234 extracellular-glutamate-gated ion channel activity(GO:0005234)
0.1 10.3 GO:0050660 flavin adenine dinucleotide binding(GO:0050660)
0.1 5.3 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 1.5 GO:0070008 serine-type exopeptidase activity(GO:0070008)
0.1 8.2 GO:0017022 myosin binding(GO:0017022)
0.1 2.4 GO:0004622 lysophospholipase activity(GO:0004622)
0.1 12.6 GO:0005178 integrin binding(GO:0005178)
0.1 12.7 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.1 1.3 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.1 1.6 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.1 2.4 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 4.9 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 0.6 GO:0070097 delta-catenin binding(GO:0070097)
0.1 4.5 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 2.2 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.1 4.3 GO:0016763 transferase activity, transferring pentosyl groups(GO:0016763)
0.1 2.5 GO:0070888 E-box binding(GO:0070888)
0.1 6.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 2.7 GO:0032813 tumor necrosis factor receptor superfamily binding(GO:0032813)
0.1 1.2 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.1 1.1 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.1 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 4.5 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.0 7.1 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.0 4.4 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.0 6.4 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 1.4 GO:0098632 protein binding involved in cell-cell adhesion(GO:0098632)
0.0 22.4 GO:0008289 lipid binding(GO:0008289)
0.0 0.8 GO:0004623 phospholipase A2 activity(GO:0004623)
0.0 0.1 GO:0004066 asparagine synthase (glutamine-hydrolyzing) activity(GO:0004066)
0.0 3.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.4 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.0 0.3 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 6.4 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 0.3 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 9.4 GO:0043565 sequence-specific DNA binding(GO:0043565)
0.0 0.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
0.0 3.9 GO:0005525 GTP binding(GO:0005525)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 17.9 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.8 23.6 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 11.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.3 3.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 24.9 PID CMYB PATHWAY C-MYB transcription factor network
0.2 8.4 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.2 5.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.2 2.8 PID LYMPH ANGIOGENESIS PATHWAY VEGFR3 signaling in lymphatic endothelium
0.2 26.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 6.3 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 2.4 PID S1P S1P2 PATHWAY S1P2 pathway
0.2 1.9 PID ARF6 DOWNSTREAM PATHWAY Arf6 downstream pathway
0.2 4.1 PID AP1 PATHWAY AP-1 transcription factor network
0.2 9.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 4.2 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 23.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 7.5 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.1 8.0 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 2.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 9.0 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 6.1 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.4 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.9 PID IL1 PATHWAY IL1-mediated signaling events
0.1 1.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.1 1.0 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 2.6 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 2.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 1.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 48.7 REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS Genes involved in Phase 1 - Functionalization of compounds
0.8 24.4 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.8 12.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.8 15.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.7 36.0 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.7 6.1 REACTOME TRYPTOPHAN CATABOLISM Genes involved in Tryptophan catabolism
0.6 7.4 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.6 8.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.5 7.4 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.4 6.2 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.4 6.8 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.3 6.7 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.3 3.3 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 13.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.2 9.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.2 3.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.2 3.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.2 7.7 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.2 14.8 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.2 3.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.2 1.6 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
0.2 5.9 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.1 17.4 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.1 6.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.0 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.3 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.1 6.3 REACTOME NGF SIGNALLING VIA TRKA FROM THE PLASMA MEMBRANE Genes involved in NGF signalling via TRKA from the plasma membrane
0.1 4.3 REACTOME SPHINGOLIPID METABOLISM Genes involved in Sphingolipid metabolism
0.1 3.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.1 2.8 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 1.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 2.6 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.1 1.6 REACTOME SIGNALING BY NOTCH1 Genes involved in Signaling by NOTCH1
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME ACYL CHAIN REMODELLING OF PG Genes involved in Acyl chain remodelling of PG
0.0 1.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 5.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 3.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 1.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 2.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 2.3 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.0 1.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.0 0.2 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.0 0.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors