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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Thra

Z-value: 0.77

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Transcription factors associated with Thra

Gene Symbol Gene ID Gene Info
Thra
ENSRNOG00000009066 thyroid hormone receptor alpha

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Thrarn6_v1_chr10_+_86657285_866572850.195.1e-04Click!

Activity profile of Thra motif

Sorted Z-values of Thra motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_+_33606124 30.28 ENSRNOT00000065210
AC115371.1

chr1_+_80321585 29.80 ENSRNOT00000022895
Ckm
creatine kinase, M-type
chr11_+_80736576 27.48 ENSRNOT00000047678
Masp1
mannan-binding lectin serine peptidase 1
chr15_+_33632416 27.39 ENSRNOT00000068212
AC130940.1

chr8_+_50559126 27.28 ENSRNOT00000024918
Apoa5
apolipoprotein A5
chr12_+_45905371 21.29 ENSRNOT00000039275
Hspb8
heat shock protein family B (small) member 8
chr1_+_215609036 19.20 ENSRNOT00000076187
Tnni2
troponin I2, fast skeletal type
chr7_-_80796670 18.43 ENSRNOT00000010539
Abra
actin-binding Rho activating protein
chr10_+_82775691 16.32 ENSRNOT00000030737
Hils1
histone linker H1 domain, spermatid-specific 1
chr4_-_145948996 16.03 ENSRNOT00000043476
Atp2b2
ATPase plasma membrane Ca2+ transporting 2
chr10_-_18443934 15.04 ENSRNOT00000059895
ENSRNOT00000080021
Ranbp17
RAN binding protein 17
chr17_+_76002275 14.78 ENSRNOT00000092665
ENSRNOT00000086701
Echdc3
enoyl CoA hydratase domain containing 3
chr9_+_92435896 13.13 ENSRNOT00000022901
Fbxo36
F-box protein 36
chr1_+_72425707 12.63 ENSRNOT00000058956
Sbk2
SH3 domain binding kinase family, member 2
chr5_-_76039760 12.20 ENSRNOT00000019959
RGD1306148
similar to KIAA0368
chr2_+_229196616 11.78 ENSRNOT00000012773
Ndst4
N-deacetylase and N-sulfotransferase 4
chr1_-_89488223 11.63 ENSRNOT00000028624
Fxyd1
FXYD domain-containing ion transport regulator 1
chr8_+_50537009 11.62 ENSRNOT00000080658
Apoa4
apolipoprotein A4
chr1_+_177048655 11.01 ENSRNOT00000081595
Mical2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr12_+_24978483 10.88 ENSRNOT00000040069
Eln
elastin
chr11_-_83905889 10.33 ENSRNOT00000075606
Fam131a
family with sequence similarity 131, member A
chr11_-_82884660 10.31 ENSRNOT00000073526
LOC100912498
protein FAM131A-like
chr1_+_137799185 10.03 ENSRNOT00000083590
ENSRNOT00000092778
Agbl1
ATP/GTP binding protein-like 1
chr7_-_123586919 9.93 ENSRNOT00000011484
Ndufa6
NADH:ubiquinone oxidoreductase subunit A6
chr17_+_77167740 9.85 ENSRNOT00000042881
Optn
optineurin
chr11_-_4332255 9.64 ENSRNOT00000087133
Cadm2
cell adhesion molecule 2
chr1_-_66212418 9.61 ENSRNOT00000026074
LOC691722
hypothetical protein LOC691722
chr16_+_23553647 9.28 ENSRNOT00000041994
Psd3
pleckstrin and Sec7 domain containing 3
chr17_+_36334147 9.27 ENSRNOT00000050261
E2f3
E2F transcription factor 3
chr11_+_64601029 9.15 ENSRNOT00000004138
Arhgap31
Rho GTPase activating protein 31
chr3_-_2727616 9.12 ENSRNOT00000061904
C8g
complement C8 gamma chain
chr6_+_2216623 8.74 ENSRNOT00000008045
Rmdn2
regulator of microtubule dynamics 2
chr20_+_5008508 8.69 ENSRNOT00000001153
Vwa7
von Willebrand factor A domain containing 7
chr13_+_51034256 8.68 ENSRNOT00000004528
ENSRNOT00000046854
ENSRNOT00000087320
Mybph
myosin binding protein H
chr10_+_39435227 8.21 ENSRNOT00000042144
ENSRNOT00000077185
P4ha2
prolyl 4-hydroxylase subunit alpha 2
chr15_-_3544685 7.69 ENSRNOT00000015179
ENSRNOT00000085126
Vcl
vinculin
chr1_+_84067938 7.57 ENSRNOT00000057213
Numbl
NUMB-like, endocytic adaptor protein
chr1_+_228142778 7.53 ENSRNOT00000028517
Mrpl16
mitochondrial ribosomal protein L16
chr2_+_98252925 7.48 ENSRNOT00000011579
Pex2
peroxisomal biogenesis factor 2
chr6_-_122721496 7.45 ENSRNOT00000079697
Ptpn21
protein tyrosine phosphatase, non-receptor type 21
chr7_-_33916338 7.27 ENSRNOT00000005492
Cfap54
cilia and flagella associated protein 54
chr6_-_135829953 7.06 ENSRNOT00000080623
ENSRNOT00000039059
Cdc42bpb
CDC42 binding protein kinase beta
chr3_+_37545238 6.43 ENSRNOT00000070792
Tnfaip6
TNF alpha induced protein 6
chr3_-_134406576 6.10 ENSRNOT00000081589
Sel1l2
SEL1L2 ERAD E3 ligase adaptor subunit
chr3_+_148510779 6.03 ENSRNOT00000012156
Xkr7
XK related 7
chrX_+_68752597 5.54 ENSRNOT00000077039
Stard8
StAR-related lipid transfer domain containing 8
chr13_-_74740458 5.24 ENSRNOT00000006548
Tex35
testis expressed 35
chr4_-_99746560 5.18 ENSRNOT00000012021
Mrpl35
mitochondrial ribosomal protein L35
chr1_+_250426158 5.08 ENSRNOT00000067643
A1cf
APOBEC1 complementation factor
chr3_+_143129248 4.95 ENSRNOT00000006667
Cst8
cystatin 8
chr14_+_12218553 4.81 ENSRNOT00000003237
Prkg2
protein kinase, cGMP-dependent, type II
chr18_+_30574627 4.72 ENSRNOT00000060484
Pcdhb19
protocadherin beta 19
chr1_-_59732409 4.67 ENSRNOT00000014824
Has1
hyaluronan synthase 1
chr1_-_80716143 4.45 ENSRNOT00000092048
ENSRNOT00000025829
Cblc
Cbl proto-oncogene C
chr6_+_7961413 4.35 ENSRNOT00000007638
ENSRNOT00000061871
Abcg8
ATP binding cassette subfamily G member 8
chr9_+_111597037 4.34 ENSRNOT00000021758
Fer
FER tyrosine kinase
chr8_-_47339343 4.31 ENSRNOT00000081007
Arhgef12
Rho guanine nucleotide exchange factor 12
chr4_-_45332420 4.27 ENSRNOT00000083039
Wnt2
wingless-type MMTV integration site family member 2
chr3_+_95715193 4.13 ENSRNOT00000089525
Pax6
paired box 6
chr6_+_112203679 4.13 ENSRNOT00000031205
Nrxn3
neurexin 3
chr19_+_37675113 4.11 ENSRNOT00000024125
RGD1561415
RGD1561415
chr20_+_31102476 4.03 ENSRNOT00000078719
Lrrc20
leucine rich repeat containing 20
chrX_+_54734385 4.02 ENSRNOT00000005023
Nr0b1
nuclear receptor subfamily 0, group B, member 1
chr1_-_169334093 3.98 ENSRNOT00000032587
Ubqln3
ubiquilin 3
chr3_-_60813869 3.96 ENSRNOT00000058234
Atp5g3
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)
chr5_+_14415606 3.95 ENSRNOT00000089273
Rgs20
regulator of G-protein signaling 20
chr10_+_85608544 3.89 ENSRNOT00000092122
Mllt6
MLLT6, PHD finger domain containing
chr1_+_82174451 3.86 ENSRNOT00000027783
Tmem145
transmembrane protein 145
chr5_+_58416432 3.65 ENSRNOT00000039366
LOC100360821
rCG55159-like
chr10_+_72486152 3.56 ENSRNOT00000004193
RGD1310166
similar to Chromodomain-helicase-DNA-binding protein 1 (CHD-1)
chr20_+_27352276 3.40 ENSRNOT00000076534
Rn50_20_0292.1

chr5_+_173274774 3.28 ENSRNOT00000025952
Ccnl2
cyclin L2
chr10_-_85435016 3.27 ENSRNOT00000079921
4933428G20Rik
RIKEN cDNA 4933428G20 gene
chr1_-_214414763 3.24 ENSRNOT00000025240
ENSRNOT00000077776
LOC100911440
mitochondrial glutamate carrier 1-like
chr9_+_93445002 3.17 ENSRNOT00000025029
LOC501180
similar to hypothetical protein MGC35154
chrX_-_107442878 3.09 ENSRNOT00000052302
Glra4
glycine receptor, alpha 4
chr6_+_137243185 3.06 ENSRNOT00000030879
Zbtb42
zinc finger and BTB domain containing 42
chr7_-_122926336 3.05 ENSRNOT00000000205
Chadl
chondroadherin-like
chr1_+_268189277 3.01 ENSRNOT00000065001
Sorcs3
sortilin-related VPS10 domain containing receptor 3
chr9_+_88494676 2.98 ENSRNOT00000089451
LOC102556337
mitochondrial fission factor-like
chr8_+_116332796 2.92 ENSRNOT00000021408
Hyal1
hyaluronoglucosaminidase 1
chr7_-_20070772 2.91 ENSRNOT00000071008
LOC102551633
sperm motility kinase W-like
chr3_-_2845593 2.85 ENSRNOT00000067479
Tmem141
transmembrane protein 141
chr10_+_85257876 2.78 ENSRNOT00000014752
Mrpl45
mitochondrial ribosomal protein L45
chr6_-_114488880 2.71 ENSRNOT00000087560
AC118957.1

chr5_+_14415841 2.63 ENSRNOT00000010682
Rgs20
regulator of G-protein signaling 20
chr4_+_57715946 2.35 ENSRNOT00000079059
ENSRNOT00000034429
Klhdc10
kelch domain containing 10
chr3_-_2434257 2.23 ENSRNOT00000013278
Stpg3
sperm-tail PG-rich repeat containing 3
chr3_+_140024043 2.14 ENSRNOT00000086409
Rin2
Ras and Rab interactor 2
chr10_-_87521514 2.13 ENSRNOT00000084668
ENSRNOT00000071705
Krtap2-4l
keratin associated protein 2-4-like
chr5_+_147692391 2.04 ENSRNOT00000064855
Fam229a
family with sequence similarity 229, member A
chr10_-_102423084 2.01 ENSRNOT00000065145
Sdk2
sidekick cell adhesion molecule 2
chr19_-_42180981 1.95 ENSRNOT00000019577
Pmfbp1
polyamine modulated factor 1 binding protein 1
chr4_-_71958774 1.93 ENSRNOT00000024076
Olr804
olfactory receptor 804
chr15_-_86142672 1.85 ENSRNOT00000057830
Commd6
COMM domain containing 6
chr10_-_65329279 1.64 ENSRNOT00000088721
ENSRNOT00000078757
ENSRNOT00000014104
ENSRNOT00000014118
Flot2
flotillin 2
chr4_-_145487426 1.56 ENSRNOT00000013488
Emc3
ER membrane protein complex subunit 3
chr10_-_87535438 1.51 ENSRNOT00000086873
Krtap2-4
keratin associated protein 2-4
chr10_-_91807937 1.45 ENSRNOT00000005074
Wnt9b
wingless-type MMTV integration site family, member 9B
chr15_-_34444244 1.40 ENSRNOT00000027612
Cideb
cell death-inducing DFFA-like effector b
chr6_-_115616766 1.39 ENSRNOT00000006143
ENSRNOT00000045870
Sel1l
SEL1L ERAD E3 ligase adaptor subunit
chr12_+_49578633 1.37 ENSRNOT00000072683
Crybb2
crystallin, beta B2
chr1_-_168144280 1.36 ENSRNOT00000020969
Olr69
olfactory receptor 69
chr20_+_5815837 1.32 ENSRNOT00000036999
Lhfpl5
lipoma HMGIC fusion partner-like 5
chr6_+_136279496 1.24 ENSRNOT00000091946
Apopt1
apoptogenic 1, mitochondrial
chr10_-_12386222 1.21 ENSRNOT00000060994
Olr1364
olfactory receptor 1364
chr16_-_69242028 1.19 ENSRNOT00000019002
Zfp703
zinc finger protein 703
chr1_+_72635267 1.03 ENSRNOT00000090636
Il11
interleukin 11
chr2_-_30127269 0.97 ENSRNOT00000023869
Cartpt
CART prepropeptide
chr15_+_86153628 0.78 ENSRNOT00000012842
Uchl3
ubiquitin C-terminal hydrolase L3
chr1_-_64446818 0.75 ENSRNOT00000081980
Myadm
myeloid-associated differentiation marker
chr6_+_110624856 0.69 ENSRNOT00000014017
Vash1
vasohibin 1
chr19_-_27535792 0.67 ENSRNOT00000024040
Olr1666
olfactory receptor 1666
chr7_+_139444994 0.66 ENSRNOT00000090079
Tmem106c
transmembrane protein 106C
chr4_+_35279063 0.60 ENSRNOT00000011833
Nxph1
neurexophilin 1
chr9_-_92435363 0.48 ENSRNOT00000093735
ENSRNOT00000022822
ENSRNOT00000093245
Trip12
thyroid hormone receptor interactor 12
chr3_-_171134655 0.31 ENSRNOT00000028960
RGD1561252
similar to Ubiquitin carboxyl-terminal hydrolase isozyme L3 (Ubiquitin thiolesterase L3)
chr5_-_126911520 0.28 ENSRNOT00000091521
Dio1
deiodinase, iodothyronine, type I
chr7_+_70580198 0.23 ENSRNOT00000083472
ENSRNOT00000008941
Ddit3
DNA-damage inducible transcript 3
chr5_+_116421894 0.13 ENSRNOT00000080577
ENSRNOT00000086628
ENSRNOT00000004017
Nfia
nuclear factor I/A
chr4_+_153385205 0.08 ENSRNOT00000016561
Bcl2l13
BCL2 like 13

Network of associatons between targets according to the STRING database.

First level regulatory network of Thra

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.3 GO:0010901 regulation of very-low-density lipoprotein particle remodeling(GO:0010901)
3.9 11.6 GO:0034445 regulation of plasma lipoprotein particle oxidation(GO:0034444) negative regulation of plasma lipoprotein particle oxidation(GO:0034445) multicellular organism lipid catabolic process(GO:0044240)
3.7 11.0 GO:0019417 sulfur oxidation(GO:0019417)
3.6 10.9 GO:0071298 cellular response to L-ascorbic acid(GO:0071298)
2.9 11.6 GO:1903797 positive regulation of inorganic anion transmembrane transport(GO:1903797)
2.5 7.6 GO:0021849 neuroblast division in subventricular zone(GO:0021849)
2.3 27.5 GO:2000258 negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
2.0 16.0 GO:0048840 otolith development(GO:0048840)
1.7 10.0 GO:0035609 C-terminal protein deglutamylation(GO:0035609)
1.6 4.8 GO:2001226 negative regulation of chloride transport(GO:2001226)
1.5 2.9 GO:0036118 hyaluranon cable assembly(GO:0036118) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.4 4.3 GO:0030300 regulation of intestinal cholesterol absorption(GO:0030300)
1.4 4.3 GO:0060424 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation(GO:1904954)
1.4 4.1 GO:0021917 pancreatic A cell development(GO:0003322) forebrain-midbrain boundary formation(GO:0021905) somatic motor neuron fate commitment(GO:0021917) regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment(GO:0021918) sensory neuron migration(GO:1904937)
1.4 8.2 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
1.3 3.9 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
1.3 5.1 GO:0010609 mRNA localization resulting in posttranscriptional regulation of gene expression(GO:0010609) cytidine to uridine editing(GO:0016554)
1.2 9.8 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.2 4.7 GO:0046379 extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379)
1.1 4.3 GO:0038109 Kit signaling pathway(GO:0038109) diapedesis(GO:0050904)
0.9 9.3 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.9 8.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
0.7 12.2 GO:0043248 proteasome assembly(GO:0043248)
0.6 18.4 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.5 1.6 GO:1903903 regulation of establishment of T cell polarity(GO:1903903)
0.5 16.3 GO:0030261 chromosome condensation(GO:0030261)
0.4 7.5 GO:0016558 protein import into peroxisome matrix(GO:0016558)
0.4 7.3 GO:0060294 cilium movement involved in cell motility(GO:0060294)
0.4 7.7 GO:0090136 epithelial cell-cell adhesion(GO:0090136)
0.4 9.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.4 3.0 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.4 19.2 GO:0003009 skeletal muscle contraction(GO:0003009)
0.4 4.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.4 22.4 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
0.3 1.0 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.3 1.5 GO:0009786 regulation of asymmetric cell division(GO:0009786)
0.3 9.1 GO:0019835 cytolysis(GO:0019835)
0.3 3.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 3.3 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.3 3.0 GO:1900244 positive regulation of synaptic vesicle endocytosis(GO:1900244)
0.3 4.0 GO:0030238 male sex determination(GO:0030238)
0.2 0.7 GO:0090038 negative regulation of protein kinase C signaling(GO:0090038)
0.2 4.1 GO:0090129 positive regulation of synapse maturation(GO:0090129)
0.2 15.0 GO:0006611 protein export from nucleus(GO:0006611)
0.2 3.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.2 9.6 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.2 3.0 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.2 0.7 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.2 6.4 GO:0030728 ovulation(GO:0030728)
0.2 2.9 GO:0036158 outer dynein arm assembly(GO:0036158)
0.2 2.9 GO:0035404 histone-serine phosphorylation(GO:0035404)
0.1 1.0 GO:1903659 regulation of complement-dependent cytotoxicity(GO:1903659)
0.1 4.0 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.6 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
0.1 0.5 GO:0033183 negative regulation of histone ubiquitination(GO:0033183) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315)
0.1 0.9 GO:0034393 positive regulation of smooth muscle cell apoptotic process(GO:0034393)
0.1 1.3 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.1 1.2 GO:0033601 positive regulation of mammary gland epithelial cell proliferation(GO:0033601)
0.1 4.9 GO:0032543 mitochondrial translation(GO:0032543)
0.1 2.0 GO:0060219 camera-type eye photoreceptor cell differentiation(GO:0060219)
0.1 7.5 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 1.4 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.0 1.4 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.0 0.2 GO:0051409 response to nitrosative stress(GO:0051409) cellular response to nitrosative stress(GO:0071500) regulation of determination of dorsal identity(GO:2000015)
0.0 4.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 6.4 GO:0031032 actomyosin structure organization(GO:0031032)
0.0 1.9 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.0 5.0 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.8 GO:0042755 eating behavior(GO:0042755)
0.0 0.1 GO:0060074 synapse maturation(GO:0060074)
0.0 1.4 GO:0007601 visual perception(GO:0007601)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 38.9 GO:0042627 chylomicron(GO:0042627)
2.2 10.9 GO:0071953 elastic fiber(GO:0071953)
2.1 8.2 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.6 19.2 GO:0005861 troponin complex(GO:0005861)
1.4 4.3 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.3 16.0 GO:0098839 postsynaptic density membrane(GO:0098839)
1.1 7.7 GO:1990357 terminal web(GO:1990357)
1.1 7.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
1.0 2.9 GO:0036117 hyaluranon cable(GO:0036117)
0.7 5.1 GO:0045293 mRNA editing complex(GO:0045293)
0.7 8.7 GO:0005859 muscle myosin complex(GO:0005859)
0.7 16.3 GO:0001673 male germ cell nucleus(GO:0001673)
0.5 1.4 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.4 4.0 GO:0042788 polysomal ribosome(GO:0042788)
0.3 4.0 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 12.2 GO:0005771 multivesicular body(GO:0005771)
0.2 9.6 GO:0032809 neuronal cell body membrane(GO:0032809)
0.2 12.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 15.0 GO:0005643 nuclear pore(GO:0005643)
0.2 11.6 GO:0034707 chloride channel complex(GO:0034707)
0.2 9.9 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 2.9 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 1.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 1.6 GO:0016600 flotillin complex(GO:0016600)
0.1 9.8 GO:0005776 autophagosome(GO:0005776)
0.1 1.9 GO:0001520 outer dense fiber(GO:0001520)
0.1 1.3 GO:0032426 stereocilium tip(GO:0032426)
0.1 0.2 GO:0036488 CHOP-C/EBP complex(GO:0036488) CHOP-ATF3 complex(GO:1990622)
0.1 9.1 GO:0072562 blood microparticle(GO:0072562)
0.1 7.2 GO:0000922 spindle pole(GO:0000922)
0.0 3.6 GO:0045095 keratin filament(GO:0045095)
0.0 24.3 GO:0015629 actin cytoskeleton(GO:0015629)
0.0 66.0 GO:0005615 extracellular space(GO:0005615)
0.0 3.0 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.0 6.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.4 GO:0005811 lipid particle(GO:0005811)
0.0 10.2 GO:0044456 synapse part(GO:0044456)
0.0 1.2 GO:0016363 nuclear matrix(GO:0016363)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
9.1 27.3 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
4.3 29.8 GO:0004111 creatine kinase activity(GO:0004111)
4.0 16.0 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
3.6 10.9 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
3.2 19.2 GO:0031014 troponin T binding(GO:0031014)
2.1 8.2 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656)
2.0 9.8 GO:0001155 TFIIIA-class transcription factor binding(GO:0001155)
2.0 11.8 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.9 11.6 GO:0060228 phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228)
1.9 15.0 GO:0005049 nuclear export signal receptor activity(GO:0005049)
1.5 7.6 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.0 4.0 GO:0050682 AF-2 domain binding(GO:0050682)
1.0 4.8 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.9 8.7 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.6 3.2 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.6 7.7 GO:0045294 alpha-catenin binding(GO:0045294)
0.5 9.1 GO:0001848 complement binding(GO:0001848)
0.4 3.1 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.4 11.0 GO:0071949 FAD binding(GO:0071949)
0.4 4.1 GO:0003680 AT DNA binding(GO:0003680)
0.4 10.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.4 27.5 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.4 4.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.4 9.3 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 4.3 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 6.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.2 4.0 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 4.3 GO:0048018 receptor agonist activity(GO:0048018)
0.2 2.9 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 12.2 GO:0032947 protein complex scaffold(GO:0032947)
0.1 1.5 GO:0039706 co-receptor binding(GO:0039706)
0.1 11.6 GO:0005254 chloride channel activity(GO:0005254)
0.1 7.5 GO:0019843 rRNA binding(GO:0019843)
0.1 4.5 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 3.3 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.1 12.6 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.1 9.2 GO:0017124 SH3 domain binding(GO:0017124)
0.1 5.0 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.1 7.1 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 7.5 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.1 1.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.1 5.1 GO:0003727 single-stranded RNA binding(GO:0003727)
0.1 10.0 GO:0042393 histone binding(GO:0042393)
0.1 1.9 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.0 16.1 GO:0003779 actin binding(GO:0003779)
0.0 3.0 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0008430 selenium binding(GO:0008430)
0.0 1.0 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 4.3 GO:0001664 G-protein coupled receptor binding(GO:0001664)
0.0 1.2 GO:0070491 repressing transcription factor binding(GO:0070491)
0.0 0.8 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 1.0 GO:0070851 growth factor receptor binding(GO:0070851)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.2 15.1 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 42.3 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 6.6 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 4.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 26.0 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 4.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.1 9.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 4.3 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 3.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.0 2.1 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 27.5 REACTOME CREATION OF C4 AND C2 ACTIVATORS Genes involved in Creation of C4 and C2 activators
1.6 27.3 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.5 19.2 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.5 12.1 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.5 7.7 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.4 11.8 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.4 4.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.4 7.6 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.4 9.1 REACTOME COMPLEMENT CASCADE Genes involved in Complement cascade
0.3 9.6 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 9.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 3.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.2 4.2 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.2 9.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 30.1 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 1.4 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 6.6 REACTOME G ALPHA Z SIGNALLING EVENTS Genes involved in G alpha (z) signalling events
0.1 5.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 4.3 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.0 3.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha