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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Z-value: 1.15

Motif logo

Transcription factors associated with Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

Gene Symbol Gene ID Gene Info
ENSRNOG00000014666 transcription factor EB
ENSRNOG00000004255 upstream transcription factor 1
ENSRNOG00000003463 sterol regulatory element binding transcription factor 1
ENSRNOG00000053725 upstream transcription factor 2, c-fos interacting
ENSRNOG00000048961 basic helix-loop-helix family, member e41
ENSRNOG00000007400 sterol regulatory element binding transcription factor 2

Activity-expression correlation:

Activity profile of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Sorted Z-values of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_161298962 113.24 ENSRNOT00000066028
cathepsin A
chr10_+_84135116 81.58 ENSRNOT00000031035
homeo box B7
chr3_-_161299024 64.76 ENSRNOT00000021216
neuralized E3 ubiquitin protein ligase 2
chr7_+_65616177 59.56 ENSRNOT00000006566
glucosamine (N-acetyl)-6-sulfatase
chr5_-_164844586 59.26 ENSRNOT00000011287
chloride voltage-gated channel 6
chr7_+_63467216 51.95 ENSRNOT00000064349
N-acetylglucosamine-6-sulfatase-like
chr1_+_48176106 50.58 ENSRNOT00000021840
insulin-like growth factor 2 receptor
chr10_-_13536899 49.83 ENSRNOT00000008537
amidohydrolase domain containing 2
chr10_+_56610051 43.01 ENSRNOT00000024348
dishevelled segment polarity protein 2
chrX_-_105417323 40.88 ENSRNOT00000015494
galactosidase, alpha
chrX_+_134979646 40.64 ENSRNOT00000006035
SAM and SH3 domain containing 3
chr16_-_81706664 39.73 ENSRNOT00000026580
lysosomal-associated membrane protein 1
chr9_-_82345262 39.05 ENSRNOT00000024975
cyclin Pas1/PHO80 domain containing 1
chr14_-_84189266 38.41 ENSRNOT00000005934
transcobalamin 2
chr7_-_121058029 37.92 ENSRNOT00000068033
chromobox 6
chr13_+_70174936 37.26 ENSRNOT00000064068
ENSRNOT00000079861
ENSRNOT00000092562
actin related protein 2/3 complex, subunit 5
chr7_-_12741296 37.23 ENSRNOT00000060648
Rho GTPase activating protein 45
chr19_-_601469 36.04 ENSRNOT00000016462
pyruvate dehyrogenase phosphatase catalytic subunit 2
chr2_+_164747677 35.58 ENSRNOT00000018489
major facilitator superfamily domain containing 1
chr1_+_166991474 35.30 ENSRNOT00000027150
RhoA activator C11orf59-like
chr17_-_1879279 30.03 ENSRNOT00000025462
cathepsin L
chr7_-_67116980 29.85 ENSRNOT00000005798
protein phosphatase, Mg2+/Mn2+ dependent, 1H
chr13_-_70174565 29.41 ENSRNOT00000067135
ral guanine nucleotide dissociation stimulator,-like 1
chr5_+_90800082 28.99 ENSRNOT00000093696
ENSRNOT00000093206
lysine demethylase 4C
chr6_+_135724455 28.91 ENSRNOT00000012469
amnion associated transmembrane protein
chr2_+_187697523 28.57 ENSRNOT00000026153
glycosylated lysosomal membrane protein
chr5_-_147784311 28.13 ENSRNOT00000074172
family with sequence similarity 167, member B
chr2_+_188489362 28.01 ENSRNOT00000027815
CDC-like kinase 2
chr1_-_101457126 27.82 ENSRNOT00000087061
ENSRNOT00000028328
BCL2 associated X, apoptosis regulator
chr20_+_46250363 27.23 ENSRNOT00000076522
ENSRNOT00000000334
CD164 molecule
chr1_+_103172987 26.71 ENSRNOT00000018688
transmembrane protein 86A
chr16_+_20426566 26.53 ENSRNOT00000026225
IFI30, lysosomal thiol reductase
chr19_-_38120578 26.49 ENSRNOT00000026873
epithelial splicing regulatory protein 2
chr12_+_2054680 26.38 ENSRNOT00000001290
mucolipin 1
chr4_-_82271893 26.29 ENSRNOT00000075005
homeobox A7
chr7_+_13062196 26.15 ENSRNOT00000000193
phospholipid phosphatase 2
chr3_+_61604672 25.91 ENSRNOT00000080456
homeobox D11
chrX_-_54303729 25.91 ENSRNOT00000087919
ENSRNOT00000064340
ENSRNOT00000051249
ENSRNOT00000087547
glycerol kinase
chr1_-_32140136 25.83 ENSRNOT00000081339
ENSRNOT00000022635
solute carrier family 12 member 7
chr18_+_71395830 25.50 ENSRNOT00000024831
SMAD family member 7
chr2_-_33841499 25.27 ENSRNOT00000040533
splicing regulatory glutamic acid and lysine rich protein 1
chr5_-_79691258 24.96 ENSRNOT00000072920
tumor necrosis factor superfamily member 8
chr8_+_23014956 24.89 ENSRNOT00000018009
protein kinase C substrate 80K-H
chr6_+_26587443 24.44 ENSRNOT00000034207
MpV17 mitochondrial inner membrane protein
chrX_-_156399760 24.40 ENSRNOT00000086921
family with sequence similarity 50, member A
chr4_-_140220487 24.28 ENSRNOT00000009008
sulfatase modifying factor 1
chr11_-_68197772 24.16 ENSRNOT00000003060
ENSRNOT00000081875
Hspb associated protein 1
chr8_+_117117430 24.15 ENSRNOT00000073247
glutathione peroxidase 1
chr4_-_82186190 24.10 ENSRNOT00000071729
homeobox protein Hox-A7-like
chr17_-_67904674 23.70 ENSRNOT00000078532
Kruppel-like factor 6
chr3_+_61613774 23.61 ENSRNOT00000002148
homeo box D10
chr6_-_55001464 23.60 ENSRNOT00000006618
aryl hydrocarbon receptor
chr15_+_46316741 23.49 ENSRNOT00000014177
cathepsin B
chr14_+_63095720 23.06 ENSRNOT00000006071
PPARG coactivator 1 alpha
chr19_-_55423052 22.50 ENSRNOT00000019528
ENSRNOT00000079641
galactosamine (N-acetyl)-6-sulfatase
chr12_-_14175945 22.41 ENSRNOT00000001469
adaptor-related protein complex 5, zeta 1 subunit
chr10_+_16970626 22.03 ENSRNOT00000005383
dual specificity phosphatase 1
chr1_-_22625204 21.99 ENSRNOT00000021694
vanin 1
chr3_+_28627084 21.59 ENSRNOT00000049884
Rho GTPase activating protein 15
chr10_-_56850085 21.53 ENSRNOT00000025767
ribonuclease K
chr4_+_78694447 21.32 ENSRNOT00000011945
glycoprotein nmb
chr9_-_37144015 21.26 ENSRNOT00000015638
PHD finger protein 3
chr10_+_106785077 21.21 ENSRNOT00000075047
transmembrane channel-like 8
chrX_-_10413984 21.20 ENSRNOT00000039551
ENSRNOT00000091448
DEAD-box helicase 3, X-linked
chr11_+_73936750 21.07 ENSRNOT00000002350
ATPase 13A3
chr8_-_94922017 20.78 ENSRNOT00000083934
centrosomal protein 162
chr5_-_164898420 20.65 ENSRNOT00000011747
angiotensin II receptor-associated protein
chr8_+_50310405 20.59 ENSRNOT00000073507
SIK family kinase 3
chr19_-_55257876 20.46 ENSRNOT00000017564
cytochrome b-245 alpha chain
chr5_+_78120607 20.44 ENSRNOT00000019379
solute carrier family 31 member 2
chr17_+_10463303 20.40 ENSRNOT00000060822
ring finger protein 44
chr1_-_215553451 20.22 ENSRNOT00000027407
cathepsin D
chr12_-_48365784 20.21 ENSRNOT00000077317
D-amino-acid oxidase
chr1_-_260254600 20.21 ENSRNOT00000019014
B-cell linker
chr10_+_84167331 20.21 ENSRNOT00000010965
homeo box B4
chr3_-_2573387 20.09 ENSRNOT00000017271
dipeptidylpeptidase 7
chr8_-_23146689 19.96 ENSRNOT00000092200
acid phosphatase 5, tartrate resistant
chr19_-_37525762 19.70 ENSRNOT00000023606
ATPase H+ transporting V0 subunit D1
chr10_+_47961056 19.64 ENSRNOT00000027312
family with sequence similarity 83, member G
chr19_+_9622611 19.53 ENSRNOT00000061498
solute carrier family 38, member 7
chr20_-_5533448 19.41 ENSRNOT00000000568
cutA divalent cation tolerance homolog
chr4_-_82194927 19.27 ENSRNOT00000072302
homeobox protein Hox-A9
chr7_+_2737765 18.99 ENSRNOT00000004895
canopy FGF signaling regulator 2
chr10_-_14215957 18.73 ENSRNOT00000019767
fumarylacetoacetate hydrolase domain containing 1
chr2_-_259898525 18.71 ENSRNOT00000082253
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
chr3_+_72238981 18.68 ENSRNOT00000011006
solute carrier family 43 member 1
chr1_+_154377447 18.67 ENSRNOT00000084268
ENSRNOT00000092086
ENSRNOT00000091470
ENSRNOT00000025415
phosphatidylinositol binding clathrin assembly protein
chr6_-_3794489 18.54 ENSRNOT00000087891
ENSRNOT00000011000
ENSRNOT00000084499
THUMP domain containing 2
chr12_+_23544287 18.53 ENSRNOT00000001938
ORAI calcium release-activated calcium modulator 2
chr10_+_90376933 18.46 ENSRNOT00000028557
granulin precursor
chr1_-_73660593 18.43 ENSRNOT00000038802
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5
chr1_-_282170017 18.27 ENSRNOT00000066947
eukaryotic translation initiation factor 3, subunit A
chr6_+_86785771 18.07 ENSRNOT00000066702
pre-mRNA processing factor 39
chr1_-_170594168 18.07 ENSRNOT00000026280
tripeptidyl peptidase 1
chr10_-_4644570 18.04 ENSRNOT00000088279
stannin
chr17_+_9837402 18.04 ENSRNOT00000076436
RAB24, member RAS oncogene family
chr1_+_144601410 17.97 ENSRNOT00000047408
elongation factor like GTPase 1
chr1_-_100537377 17.94 ENSRNOT00000026599
Spi-B transcription factor
chr4_-_120840111 17.93 ENSRNOT00000022231
minichromosome maintenance complex component 2
chr12_+_22451596 17.81 ENSRNOT00000072838
thyroid hormone receptor interactor 6
chr2_+_93792601 17.58 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr5_-_138470096 17.50 ENSRNOT00000011392
phosphopantothenoylcysteine synthetase
chr1_+_154377247 17.34 ENSRNOT00000092945
phosphatidylinositol binding clathrin assembly protein
chr1_-_80544825 17.13 ENSRNOT00000057802
ENSRNOT00000040060
ENSRNOT00000067049
ENSRNOT00000052387
ENSRNOT00000073352
RELB proto-oncogene, NF-kB subunit
chr3_+_113415774 17.11 ENSRNOT00000056151
small EDRK-rich factor 2
chr10_+_90377103 17.09 ENSRNOT00000040472
granulin precursor
chr8_-_104995725 17.05 ENSRNOT00000037120
solute carrier family 25 member 36
chr19_+_26022849 17.04 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chr1_-_222495382 17.02 ENSRNOT00000028759
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr9_-_61690956 16.81 ENSRNOT00000066589
heat shock protein family D member 1
chr12_+_16340922 16.71 ENSRNOT00000001696
sorting nexin 8
chrX_+_16170576 16.67 ENSRNOT00000003895
chloride voltage-gated channel 5
chr2_-_104830898 16.65 ENSRNOT00000050440
Hermansky-Pudlak syndrome 3
chr1_-_219450451 16.50 ENSRNOT00000025317
RAD9 checkpoint clamp component A
chr10_-_62287189 16.41 ENSRNOT00000004365
WD repeat domain 81
chr2_+_188516582 16.34 ENSRNOT00000074727
glucosylceramidase beta
chr2_+_266315036 16.20 ENSRNOT00000055245
wntless Wnt ligand secretion mediator
chr5_-_50362344 16.19 ENSRNOT00000035808
zinc finger protein 292
chr2_-_178616719 15.96 ENSRNOT00000078610
transmembrane protein 144
chr17_-_9837293 15.94 ENSRNOT00000091320
ENSRNOT00000022134
PRELI domain containing 1
chr11_-_38457373 15.87 ENSRNOT00000041177
zinc finger protein 295
chr8_-_121973125 15.85 ENSRNOT00000012114
programmed cell death 6 interacting protein
chr2_-_52282548 15.84 ENSRNOT00000033627
nicotinamide nucleotide transhydrogenase
chr20_-_5533600 15.83 ENSRNOT00000072319
cutA divalent cation tolerance homolog
chr5_+_145138697 15.69 ENSRNOT00000019135
zinc finger MYM-type containing 6
chr10_+_88997399 15.61 ENSRNOT00000027116
MLX, MAX dimerization protein
chr1_-_164101578 15.60 ENSRNOT00000022176
UV radiation resistance associated
chr5_-_166259069 15.57 ENSRNOT00000055572
ubiquitination factor E4B
chr9_-_88086488 15.55 ENSRNOT00000019579
insulin receptor substrate 1
chr3_-_175709465 15.53 ENSRNOT00000089971
GATA binding protein 5
chr10_+_29067102 15.44 ENSRNOT00000005161
C1q and tumor necrosis factor related protein 2
chr15_-_43667029 15.35 ENSRNOT00000014798
BCL2/adenovirus E1B interacting protein 3-like
chr8_-_115621394 15.32 ENSRNOT00000018995
RNA binding motif protein 15B
chr3_-_94808861 15.20 ENSRNOT00000038464
proline rich and Gla domain 4
chr1_-_228194977 15.15 ENSRNOT00000028535
syntaxin 3
chr15_-_32780603 15.13 ENSRNOT00000046980
T cell receptor delta variable 5
chr2_-_104958034 15.12 ENSRNOT00000080699
glycogenin 1
chr2_+_190007216 15.12 ENSRNOT00000015612
S100 calcium binding protein A6
chr10_+_76343847 15.04 ENSRNOT00000055674
tripartite motif-containing 25
chr13_+_109713489 15.03 ENSRNOT00000004962
basic leucine zipper ATF-like transcription factor 3
chrX_+_33599671 14.99 ENSRNOT00000006843
taxilin gamma
chr19_-_24831500 14.95 ENSRNOT00000005770
protein kinase N1
chr7_+_3332788 14.86 ENSRNOT00000010180
Cd63 molecule
chr20_-_11737050 14.72 ENSRNOT00000001637
small ubiquitin-like modifier 3
chr4_-_82215022 14.70 ENSRNOT00000010256
homeobox A11
chr6_-_26820959 14.58 ENSRNOT00000043572
ketohexokinase
chrX_-_123474154 14.56 ENSRNOT00000092415
ENSRNOT00000092455
similar to hypothetical protein FLJ22965
chr11_+_80255790 14.41 ENSRNOT00000002522
B-cell CLL/lymphoma 6
chr2_-_53827175 14.40 ENSRNOT00000078158
similar to expressed sequence AW549877
chr7_+_144628120 14.37 ENSRNOT00000022247
homeo box C5
chr2_+_122690278 14.28 ENSRNOT00000086831

chr10_-_109811323 14.06 ENSRNOT00000054970
MAF bZIP transcription factor G
chr5_-_171648327 14.06 ENSRNOT00000082847
Rho guanine nucleotide exchange factor 16
chr1_-_101123402 13.94 ENSRNOT00000027976

chr1_-_102849430 13.80 ENSRNOT00000086856
serum amyloid A4
chr2_-_195423787 13.80 ENSRNOT00000071603
selenium-binding protein 1
chr3_+_62481323 13.78 ENSRNOT00000078872
heterogeneous nuclear ribonucleoprotein A3
chr12_+_47590154 13.77 ENSRNOT00000045946
GIT ArfGAP 2
chr10_-_82326771 13.75 ENSRNOT00000004673
acyl-CoA synthetase family member 2
chr8_+_77107536 13.72 ENSRNOT00000083255
ADAM metallopeptidase domain 10
chr18_+_48132414 13.68 ENSRNOT00000050631
sorting nexin 2
chr2_-_196113149 13.54 ENSRNOT00000088465
selenium binding protein 1
chr8_+_81863619 13.49 ENSRNOT00000080608
family with sequence similarity 214, member A
chr5_-_160352927 13.38 ENSRNOT00000017247
DnaJ heat shock protein family (Hsp40) member C16
chr7_-_12673659 13.29 ENSRNOT00000091650
ENSRNOT00000041277
ENSRNOT00000044865
polypyrimidine tract binding protein 1
chr3_+_155297566 13.28 ENSRNOT00000021435
ENSRNOT00000084866
DEAH-box helicase 35
chr5_-_159577134 13.25 ENSRNOT00000011114
ciliary rootlet coiled-coil, rootletin
chr4_+_82214342 13.23 ENSRNOT00000066360
homeobox A11, opposite strand
chr5_-_171648563 13.21 ENSRNOT00000072786
Rho guanine nucleotide exchange factor 16
chr1_-_13175876 13.13 ENSRNOT00000084870
ABRA C-terminal like
chr9_+_16647598 13.02 ENSRNOT00000087413
kinesin light chain 4
chr4_+_82300778 12.94 ENSRNOT00000075254
homeobox A11, opposite strand
chr7_+_141249044 12.83 ENSRNOT00000084911
aquaporin 5
chr7_-_27213651 12.79 ENSRNOT00000077041
ENSRNOT00000076468
thymine-DNA glycosylase
chr13_+_35554964 12.73 ENSRNOT00000072632
transmembrane protein 185B
chr4_+_122365093 12.67 ENSRNOT00000024011
Kruppel-like factor 15
chr16_-_60427474 12.66 ENSRNOT00000051720
protein phosphatase 1, regulatory subunit 3B
chr19_+_14508616 12.50 ENSRNOT00000019192
heme oxygenase 1
chr10_-_74298599 12.45 ENSRNOT00000007379
yippee-like 2
chr2_+_40000313 12.45 ENSRNOT00000014270
DEP domain containing 1B
chr18_-_24397551 12.42 ENSRNOT00000023032
solute carrier family 25, member 46
chr5_+_150725654 12.42 ENSRNOT00000089852
ENSRNOT00000017740
DnaJ heat shock protein family (Hsp40) member C8
chr11_+_27364916 12.35 ENSRNOT00000002151
BTB domain and CNC homolog 1
chr8_+_70994563 12.30 ENSRNOT00000051504
ENSRNOT00000077163
spastic paraplegia 21 homolog (human)
chr10_-_35927268 12.29 ENSRNOT00000004740
RUN and FYVE domain containing 1
chrX_-_4945944 12.16 ENSRNOT00000077238
lysine demethylase 6A
chr14_-_2056762 12.14 ENSRNOT00000000048
iduronidase, alpha-L-
chr16_+_2278701 12.13 ENSRNOT00000016233
DENN domain containing 6A
chrX_+_106823491 12.13 ENSRNOT00000045997
brain expressed X-linked 3
chr7_+_41114697 12.06 ENSRNOT00000041354
ATPase plasma membrane Ca2+ transporting 1
chr10_-_76263866 11.97 ENSRNOT00000003219
serine carboxypeptidase 1
chr4_-_82300503 11.94 ENSRNOT00000071568
homeobox A11
chr6_-_102472926 11.88 ENSRNOT00000079351
zinc finger FYVE-type containing 26
chr1_+_171820423 11.80 ENSRNOT00000047831
PPFIA binding protein 2
chr7_-_140291620 11.80 ENSRNOT00000088323
adenylate cyclase 6
chr9_-_41337498 11.78 ENSRNOT00000039480
family with sequence similarity 168, member B
chr15_-_60766579 11.67 ENSRNOT00000079978
A-kinase anchoring protein 11
chrX_+_77076106 11.51 ENSRNOT00000091527
ENSRNOT00000089381
ATPase copper transporting alpha
chr4_+_99937558 11.50 ENSRNOT00000050249
ST3 beta-galactoside alpha-2,3-sialyltransferase 5
chr2_-_236395067 11.48 ENSRNOT00000014658
hydroxyacyl-CoA dehydrogenase

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfeb_Usf1_Srebf1_Usf2_Bhlhe41_Srebf2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
18.9 113.2 GO:1904714 regulation of chaperone-mediated autophagy(GO:1904714)
14.9 59.6 GO:0042339 keratan sulfate metabolic process(GO:0042339)
13.5 67.3 GO:0015889 cobalamin transport(GO:0015889)
13.2 39.7 GO:0043323 positive regulation of natural killer cell degranulation(GO:0043323)
12.8 51.4 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
12.0 36.0 GO:1902962 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902959) positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902961) regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902962) negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process(GO:1902963) regulation of aspartic-type peptidase activity(GO:1905245) positive regulation of aspartic-type peptidase activity(GO:1905247)
9.3 9.3 GO:1904586 response to putrescine(GO:1904585) cellular response to putrescine(GO:1904586)
9.3 27.8 GO:0097296 regulation of nitrogen utilization(GO:0006808) nitrogen utilization(GO:0019740) activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:0097296) regulation of mitochondrial membrane permeability involved in programmed necrotic cell death(GO:1902445)
8.6 25.9 GO:0046167 glycerol-3-phosphate biosynthetic process(GO:0046167)
8.0 24.1 GO:0009609 response to symbiotic bacterium(GO:0009609)
8.0 64.0 GO:0046477 glycosylceramide catabolic process(GO:0046477)
7.9 23.6 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
7.7 23.1 GO:1904638 cellular response to nitrite(GO:0071250) response to nitrite(GO:0080033) response to resveratrol(GO:1904638) regulation of progesterone biosynthetic process(GO:2000182)
7.5 37.5 GO:0009758 carbohydrate utilization(GO:0009758)
7.2 43.0 GO:0044340 canonical Wnt signaling pathway involved in regulation of cell proliferation(GO:0044340)
6.8 20.5 GO:1904844 response to L-glutamine(GO:1904844) cellular response to L-glutamine(GO:1904845)
6.8 40.9 GO:0032439 endosome localization(GO:0032439)
6.8 20.3 GO:0042412 taurine biosynthetic process(GO:0042412)
6.7 20.2 GO:0046416 D-amino acid metabolic process(GO:0046416)
6.7 26.9 GO:0032763 regulation of mast cell cytokine production(GO:0032763)
6.5 19.5 GO:0089709 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
6.3 19.0 GO:0045716 positive regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045716)
6.1 18.2 GO:0043311 positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
5.9 17.8 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
5.9 35.6 GO:0001835 blastocyst hatching(GO:0001835) hatching(GO:0035188) organism emergence from protective structure(GO:0071684)
5.9 23.6 GO:0040009 regulation of growth rate(GO:0040009)
5.7 17.0 GO:0061357 positive regulation of Wnt protein secretion(GO:0061357)
5.6 16.8 GO:0002840 T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840)
5.6 39.2 GO:0042256 mature ribosome assembly(GO:0042256)
5.5 27.4 GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I(GO:0042590)
5.3 37.2 GO:0048102 autophagic cell death(GO:0048102)
5.3 15.8 GO:0044837 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
5.3 15.8 GO:0060764 cell-cell signaling involved in mammary gland development(GO:0060764)
5.2 15.5 GO:1901420 negative regulation of vitamin D receptor signaling pathway(GO:0070563) negative regulation of response to alcohol(GO:1901420)
4.7 60.9 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
4.7 4.7 GO:0061034 olfactory bulb mitral cell layer development(GO:0061034)
4.6 4.6 GO:0002397 MHC class I protein complex assembly(GO:0002397)
4.6 13.7 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
4.6 18.3 GO:0002188 translation reinitiation(GO:0002188)
4.4 13.3 GO:0032053 ciliary basal body organization(GO:0032053) positive regulation of protein localization to cilium(GO:1903566)
4.1 12.4 GO:0090149 mitochondrial membrane fission(GO:0090149)
4.1 37.3 GO:0021769 orbitofrontal cortex development(GO:0021769)
4.1 8.2 GO:0030043 actin filament fragmentation(GO:0030043)
4.1 16.4 GO:0021615 glossopharyngeal nerve morphogenesis(GO:0021615)
4.1 4.1 GO:0016240 autophagosome docking(GO:0016240)
4.1 32.6 GO:1900113 negative regulation of histone H3-K9 trimethylation(GO:1900113)
4.0 12.1 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
4.0 20.2 GO:0048539 bone marrow development(GO:0048539)
4.0 28.2 GO:0045656 negative regulation of monocyte differentiation(GO:0045656)
3.9 15.6 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
3.9 15.6 GO:0008626 granzyme-mediated apoptotic signaling pathway(GO:0008626)
3.8 11.4 GO:1903774 positive regulation of viral budding via host ESCRT complex(GO:1903774)
3.8 11.3 GO:0042822 pyridoxal phosphate metabolic process(GO:0042822)
3.6 25.5 GO:2000317 negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320)
3.5 10.4 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
3.4 23.7 GO:0071409 cellular response to cycloheximide(GO:0071409)
3.3 9.9 GO:0006552 leucine catabolic process(GO:0006552)
3.3 22.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
3.2 15.9 GO:1901857 positive regulation of cellular respiration(GO:1901857)
3.2 9.5 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
3.1 9.4 GO:0031296 B cell costimulation(GO:0031296)
3.1 81.6 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
3.1 12.5 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
3.1 9.4 GO:0035964 COPI-coated vesicle budding(GO:0035964)
3.1 18.4 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
3.0 14.9 GO:0002634 regulation of germinal center formation(GO:0002634)
3.0 5.9 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
3.0 11.8 GO:1900224 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
2.9 40.6 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
2.9 11.5 GO:1904959 negative regulation of iron ion transmembrane transport(GO:0034760) elastin biosynthetic process(GO:0051542) regulation of cytochrome-c oxidase activity(GO:1904959)
2.8 11.3 GO:0090204 protein localization to nuclear pore(GO:0090204)
2.7 8.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
2.7 32.4 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
2.7 13.3 GO:0070094 positive regulation of glucagon secretion(GO:0070094)
2.5 2.5 GO:1902304 positive regulation of potassium ion export(GO:1902304)
2.5 9.9 GO:0050787 detoxification of mercury ion(GO:0050787)
2.4 12.2 GO:0071557 histone H3-K27 demethylation(GO:0071557)
2.4 9.7 GO:0046951 ketone body biosynthetic process(GO:0046951)
2.4 12.1 GO:0030205 dermatan sulfate metabolic process(GO:0030205)
2.4 4.8 GO:0009608 response to symbiont(GO:0009608)
2.4 7.2 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
2.4 4.7 GO:1904587 response to glycoprotein(GO:1904587)
2.4 7.1 GO:0035694 mitochondrial protein catabolic process(GO:0035694)
2.3 7.0 GO:0021997 neural plate axis specification(GO:0021997)
2.3 30.4 GO:0034498 early endosome to Golgi transport(GO:0034498)
2.3 9.3 GO:0010748 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748)
2.3 4.6 GO:1903463 regulation of mitotic cell cycle DNA replication(GO:1903463)
2.3 16.0 GO:0043622 cortical microtubule organization(GO:0043622)
2.3 11.4 GO:0009052 pentose-phosphate shunt, non-oxidative branch(GO:0009052)
2.3 6.8 GO:0009227 nucleotide-sugar catabolic process(GO:0009227)
2.3 18.1 GO:0000395 mRNA 5'-splice site recognition(GO:0000395)
2.2 6.7 GO:0044565 dendritic cell proliferation(GO:0044565)
2.2 6.7 GO:0032258 CVT pathway(GO:0032258)
2.2 6.5 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
2.2 15.2 GO:0098881 exocytic insertion of neurotransmitter receptor to plasma membrane(GO:0098881) exocytic insertion of neurotransmitter receptor to postsynaptic membrane(GO:0098967)
2.1 8.6 GO:0051142 regulation of NK T cell proliferation(GO:0051140) positive regulation of NK T cell proliferation(GO:0051142)
2.1 6.4 GO:1903070 negative regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903070)
2.1 4.2 GO:0071288 cellular response to mercury ion(GO:0071288)
2.1 6.2 GO:0030327 prenylated protein catabolic process(GO:0030327)
2.1 25.0 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
2.0 4.1 GO:0035973 aggrephagy(GO:0035973)
2.0 46.0 GO:0002115 store-operated calcium entry(GO:0002115)
2.0 2.0 GO:0070237 positive regulation of activation-induced cell death of T cells(GO:0070237)
2.0 11.8 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
2.0 7.9 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.9 5.7 GO:0006478 peptidyl-tyrosine sulfation(GO:0006478)
1.9 7.6 GO:1902683 regulation of receptor localization to synapse(GO:1902683)
1.9 5.7 GO:0060665 regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665)
1.9 16.9 GO:0001766 membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580)
1.9 24.4 GO:0032836 glomerular basement membrane development(GO:0032836)
1.9 20.6 GO:0038166 angiotensin-activated signaling pathway(GO:0038166)
1.9 3.7 GO:0002086 diaphragm contraction(GO:0002086)
1.9 14.9 GO:2000680 regulation of rubidium ion transport(GO:2000680)
1.9 5.6 GO:0021882 regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment(GO:0021882) commitment of multipotent stem cells to neuronal lineage in forebrain(GO:0021898)
1.8 12.9 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
1.8 12.8 GO:0015670 carbon dioxide transport(GO:0015670)
1.8 7.3 GO:0015811 L-cystine transport(GO:0015811)
1.8 16.4 GO:0035434 copper ion transmembrane transport(GO:0035434)
1.8 21.5 GO:0071493 cellular response to UV-B(GO:0071493)
1.8 19.7 GO:0005981 regulation of glycogen catabolic process(GO:0005981)
1.8 1.8 GO:0033364 mast cell secretory granule organization(GO:0033364)
1.8 5.4 GO:0046604 positive regulation of mitotic centrosome separation(GO:0046604)
1.8 5.3 GO:0071529 cementum mineralization(GO:0071529)
1.8 10.6 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
1.8 21.1 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
1.7 10.5 GO:0015074 DNA integration(GO:0015074)
1.7 7.0 GO:0044725 chromatin reprogramming in the zygote(GO:0044725)
1.7 6.9 GO:0046121 deoxyribonucleoside catabolic process(GO:0046121)
1.7 8.6 GO:0002003 angiotensin maturation(GO:0002003)
1.7 15.4 GO:0046479 glycosphingolipid catabolic process(GO:0046479)
1.7 8.5 GO:0034059 response to anoxia(GO:0034059)
1.7 22.0 GO:0090266 regulation of spindle checkpoint(GO:0090231) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) regulation of mitotic spindle checkpoint(GO:1903504)
1.7 22.0 GO:2000400 positive regulation of T cell differentiation in thymus(GO:0033089) negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway(GO:1902176) positive regulation of thymocyte aggregation(GO:2000400)
1.7 15.2 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.7 5.0 GO:0032474 otolith morphogenesis(GO:0032474)
1.7 15.1 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
1.7 5.0 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
1.7 13.3 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
1.6 31.3 GO:0006491 N-glycan processing(GO:0006491)
1.6 8.2 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
1.6 4.9 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
1.6 11.5 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
1.6 54.0 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
1.6 35.8 GO:0097503 sialylation(GO:0097503)
1.6 11.4 GO:0072717 cellular response to actinomycin D(GO:0072717)
1.6 3.2 GO:1903936 cellular response to sodium arsenite(GO:1903936)
1.6 69.4 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
1.6 7.9 GO:1904401 cellular response to Thyroid stimulating hormone(GO:1904401)
1.6 6.2 GO:0035494 SNARE complex disassembly(GO:0035494)
1.5 7.6 GO:0015808 L-alanine transport(GO:0015808)
1.5 7.5 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
1.5 6.0 GO:0048549 protein depalmitoylation(GO:0002084) positive regulation of pinocytosis(GO:0048549)
1.5 4.5 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
1.5 33.8 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
1.5 26.4 GO:0097067 cellular response to thyroid hormone stimulus(GO:0097067)
1.5 8.7 GO:0071386 cellular response to corticosterone stimulus(GO:0071386)
1.4 7.2 GO:0097332 response to antipsychotic drug(GO:0097332)
1.4 4.3 GO:1990737 negative regulation of translational initiation in response to stress(GO:0032057) response to manganese-induced endoplasmic reticulum stress(GO:1990737)
1.4 19.9 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
1.4 5.4 GO:0060857 establishment of glial blood-brain barrier(GO:0060857)
1.3 2.7 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
1.3 9.3 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
1.3 6.6 GO:0007042 lysosomal lumen acidification(GO:0007042)
1.3 17.0 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
1.3 5.2 GO:1903800 positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
1.3 3.9 GO:1904431 positive regulation of t-circle formation(GO:1904431)
1.3 15.4 GO:0046321 positive regulation of fatty acid oxidation(GO:0046321)
1.3 7.6 GO:0006189 'de novo' IMP biosynthetic process(GO:0006189)
1.3 2.5 GO:1900126 negative regulation of hyaluronan biosynthetic process(GO:1900126)
1.3 8.8 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
1.3 2.5 GO:0002447 eosinophil activation involved in immune response(GO:0002278) eosinophil mediated immunity(GO:0002447) eosinophil degranulation(GO:0043308)
1.2 2.5 GO:0042539 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.2 6.2 GO:0006685 sphingomyelin catabolic process(GO:0006685)
1.2 1.2 GO:0097167 circadian regulation of translation(GO:0097167)
1.2 14.6 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
1.2 21.6 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
1.2 4.7 GO:0033668 negative regulation by symbiont of host apoptotic process(GO:0033668) negative regulation by symbiont of host programmed cell death(GO:0052041) negative regulation by organism of programmed cell death in other organism involved in symbiotic interaction(GO:0052490)
1.2 10.6 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
1.2 9.4 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
1.2 19.8 GO:0072112 renal filtration cell differentiation(GO:0061318) glomerular visceral epithelial cell differentiation(GO:0072112) glomerular epithelial cell differentiation(GO:0072311)
1.2 4.7 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
1.2 10.4 GO:0045759 cannabinoid signaling pathway(GO:0038171) negative regulation of action potential(GO:0045759)
1.1 1.1 GO:2000259 positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
1.1 3.4 GO:1903542 negative regulation of exosomal secretion(GO:1903542)
1.1 10.1 GO:0018344 protein geranylgeranylation(GO:0018344)
1.1 3.3 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
1.1 5.4 GO:1903223 cellular response to temperature stimulus(GO:0071502) positive regulation of oxidative stress-induced neuron death(GO:1903223)
1.1 5.4 GO:1904528 positive regulation of microtubule binding(GO:1904528)
1.1 7.6 GO:0016259 selenocysteine metabolic process(GO:0016259)
1.1 4.2 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
1.1 3.2 GO:0033123 positive regulation of purine nucleotide catabolic process(GO:0033123)
1.0 6.3 GO:2000051 negative regulation of non-canonical Wnt signaling pathway(GO:2000051)
1.0 17.6 GO:0050872 white fat cell differentiation(GO:0050872)
1.0 25.7 GO:0097352 autophagosome maturation(GO:0097352)
1.0 11.2 GO:0044804 nucleophagy(GO:0044804)
1.0 29.9 GO:0009303 rRNA transcription(GO:0009303)
1.0 4.9 GO:0006868 glutamine transport(GO:0006868)
1.0 7.8 GO:0051639 actin filament network formation(GO:0051639)
1.0 23.2 GO:0060351 cartilage development involved in endochondral bone morphogenesis(GO:0060351)
1.0 41.3 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
1.0 13.4 GO:2000060 positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000060)
1.0 2.9 GO:0051124 synaptic growth at neuromuscular junction(GO:0051124)
1.0 17.2 GO:0043968 histone H2A acetylation(GO:0043968)
1.0 7.6 GO:1902715 positive regulation of interferon-gamma secretion(GO:1902715)
0.9 2.8 GO:0002192 IRES-dependent translational initiation(GO:0002192)
0.9 46.4 GO:0045214 sarcomere organization(GO:0045214)
0.9 30.3 GO:0090004 positive regulation of establishment of protein localization to plasma membrane(GO:0090004)
0.9 2.8 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.9 6.4 GO:0045059 positive thymic T cell selection(GO:0045059)
0.9 10.0 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.9 4.5 GO:0097070 ductus arteriosus closure(GO:0097070)
0.9 0.9 GO:0032349 positive regulation of aldosterone metabolic process(GO:0032346) positive regulation of aldosterone biosynthetic process(GO:0032349)
0.9 2.7 GO:0046061 dATP catabolic process(GO:0046061)
0.9 15.0 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
0.9 5.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.9 4.4 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.9 41.8 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.9 7.0 GO:0046116 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
0.9 6.9 GO:0010044 response to aluminum ion(GO:0010044)
0.9 2.6 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
0.9 3.4 GO:0035795 negative regulation of mitochondrial membrane permeability(GO:0035795)
0.9 2.6 GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900825)
0.8 5.9 GO:0061450 trophoblast cell migration(GO:0061450)
0.8 3.4 GO:0060174 limb bud formation(GO:0060174)
0.8 20.0 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.8 9.9 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.8 9.0 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.8 3.2 GO:0033132 negative regulation of glucokinase activity(GO:0033132) negative regulation of hexokinase activity(GO:1903300)
0.8 4.8 GO:2001280 positive regulation of prostaglandin biosynthetic process(GO:0031394) positive regulation of unsaturated fatty acid biosynthetic process(GO:2001280)
0.8 6.4 GO:0048304 positive regulation of isotype switching to IgG isotypes(GO:0048304)
0.8 9.4 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.8 6.3 GO:0006269 DNA replication, synthesis of RNA primer(GO:0006269)
0.8 17.9 GO:0030225 macrophage differentiation(GO:0030225)
0.8 0.8 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
0.8 7.7 GO:0016926 protein desumoylation(GO:0016926)
0.8 3.8 GO:0000960 mitochondrial RNA catabolic process(GO:0000957) regulation of mitochondrial RNA catabolic process(GO:0000960)
0.8 2.3 GO:0035483 gastric emptying(GO:0035483)
0.8 2.3 GO:2001206 positive regulation of osteoclast development(GO:2001206)
0.7 2.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.7 8.1 GO:2000641 regulation of early endosome to late endosome transport(GO:2000641)
0.7 8.8 GO:2000615 regulation of histone H3-K9 acetylation(GO:2000615)
0.7 24.9 GO:0034219 carbohydrate transmembrane transport(GO:0034219)
0.7 7.3 GO:0015886 heme transport(GO:0015886)
0.7 2.9 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
0.7 5.7 GO:0060872 semicircular canal morphogenesis(GO:0048752) semicircular canal development(GO:0060872)
0.7 1.4 GO:1990169 detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169)
0.7 2.8 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
0.7 3.5 GO:0050917 sensory perception of umami taste(GO:0050917)
0.7 4.9 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.7 2.8 GO:0019072 viral genome packaging(GO:0019072) viral RNA genome packaging(GO:0019074)
0.7 2.1 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.7 2.7 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.7 19.1 GO:0006958 complement activation, classical pathway(GO:0006958)
0.7 2.0 GO:0042414 epinephrine metabolic process(GO:0042414)
0.7 6.0 GO:0052697 xenobiotic glucuronidation(GO:0052697)
0.7 18.1 GO:0043171 peptide catabolic process(GO:0043171)
0.7 2.0 GO:0033634 positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
0.7 1.3 GO:0060154 cellular process regulating host cell cycle in response to virus(GO:0060154)
0.6 14.7 GO:0001522 pseudouridine synthesis(GO:0001522)
0.6 2.5 GO:0060454 positive regulation of gastric acid secretion(GO:0060454)
0.6 1.3 GO:1904373 response to kainic acid(GO:1904373)
0.6 1.9 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.6 1.9 GO:0061043 positive regulation of vascular wound healing(GO:0035470) regulation of vascular wound healing(GO:0061043)
0.6 3.1 GO:0090435 protein localization to nuclear envelope(GO:0090435)
0.6 6.8 GO:0006336 DNA replication-independent nucleosome assembly(GO:0006336)
0.6 6.0 GO:0072531 pyrimidine-containing compound transmembrane transport(GO:0072531)
0.6 21.5 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.6 18.7 GO:0015804 neutral amino acid transport(GO:0015804)
0.6 1.7 GO:0009197 dUDP biosynthetic process(GO:0006227) pyrimidine nucleoside diphosphate biosynthetic process(GO:0009139) pyrimidine deoxyribonucleoside diphosphate metabolic process(GO:0009196) pyrimidine deoxyribonucleoside diphosphate biosynthetic process(GO:0009197) dUDP metabolic process(GO:0046077)
0.6 11.0 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
0.6 2.9 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.6 1.7 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
0.6 12.0 GO:0042573 retinoic acid metabolic process(GO:0042573)
0.6 4.0 GO:0035879 plasma membrane lactate transport(GO:0035879)
0.6 1.1 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.6 7.2 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.6 8.3 GO:1902358 sulfate transport(GO:0008272) oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.6 3.9 GO:0003374 dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
0.5 15.3 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.5 6.9 GO:0006308 DNA catabolic process(GO:0006308)
0.5 1.6 GO:1903413 cellular response to bile acid(GO:1903413)
0.5 4.8 GO:0015747 urate transport(GO:0015747)
0.5 2.6 GO:0030421 defecation(GO:0030421)
0.5 12.1 GO:0061462 protein localization to lysosome(GO:0061462)
0.5 5.2 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.5 29.2 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.5 15.1 GO:0005978 glycogen biosynthetic process(GO:0005978) glucan biosynthetic process(GO:0009250)
0.5 3.1 GO:0015866 ADP transport(GO:0015866)
0.5 8.3 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.5 5.7 GO:0040034 regulation of development, heterochronic(GO:0040034)
0.5 5.2 GO:0070257 positive regulation of mucus secretion(GO:0070257)
0.5 8.2 GO:0000076 DNA replication checkpoint(GO:0000076)
0.5 1.5 GO:0070084 protein initiator methionine removal(GO:0070084)
0.5 1.5 GO:0070681 glutaminyl-tRNAGln biosynthesis via transamidation(GO:0070681)
0.5 3.5 GO:0015871 choline transport(GO:0015871)
0.5 4.9 GO:0006265 DNA topological change(GO:0006265)
0.5 4.4 GO:0046085 adenosine metabolic process(GO:0046085)
0.5 2.0 GO:0032808 lacrimal gland development(GO:0032808)
0.5 13.8 GO:0048266 behavioral response to pain(GO:0048266)
0.5 2.4 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.5 2.4 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
0.5 3.7 GO:0003416 endochondral bone growth(GO:0003416)
0.5 1.4 GO:0016129 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
0.4 9.7 GO:0006884 cell volume homeostasis(GO:0006884)
0.4 1.3 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.4 13.3 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.4 10.7 GO:0072661 protein targeting to plasma membrane(GO:0072661)
0.4 1.3 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
0.4 5.1 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.4 1.3 GO:0021539 subthalamus development(GO:0021539)
0.4 1.7 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
0.4 0.8 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
0.4 15.0 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.4 7.2 GO:0070266 necroptotic process(GO:0070266)
0.4 13.5 GO:0050873 brown fat cell differentiation(GO:0050873)
0.4 2.0 GO:0009298 GDP-mannose biosynthetic process(GO:0009298)
0.4 12.8 GO:0097502 mannosylation(GO:0097502)
0.4 15.8 GO:0006739 NADP metabolic process(GO:0006739)
0.4 3.1 GO:0032025 response to cobalt ion(GO:0032025)
0.4 3.4 GO:0009083 branched-chain amino acid catabolic process(GO:0009083)
0.4 1.9 GO:0019919 peptidyl-arginine methylation, to asymmetrical-dimethyl arginine(GO:0019919)
0.4 1.9 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.4 3.0 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.4 1.9 GO:0032790 ribosome disassembly(GO:0032790)
0.4 1.9 GO:1904995 negative regulation of leukocyte tethering or rolling(GO:1903237) negative regulation of leukocyte adhesion to vascular endothelial cell(GO:1904995)
0.4 5.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.4 8.1 GO:0019835 cytolysis(GO:0019835)
0.4 4.1 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.4 1.5 GO:0071955 recycling endosome to Golgi transport(GO:0071955)
0.4 3.2 GO:0044090 positive regulation of vacuole organization(GO:0044090)
0.3 6.2 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.3 7.9 GO:0040019 positive regulation of embryonic development(GO:0040019)
0.3 4.7 GO:0030071 regulation of mitotic metaphase/anaphase transition(GO:0030071)
0.3 2.7 GO:0010866 regulation of triglyceride biosynthetic process(GO:0010866)
0.3 2.7 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
0.3 3.3 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.3 7.2 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.3 4.9 GO:1901976 regulation of cell cycle checkpoint(GO:1901976)
0.3 1.6 GO:0010939 regulation of necrotic cell death(GO:0010939)
0.3 0.3 GO:0021593 rhombomere morphogenesis(GO:0021593)
0.3 1.3 GO:0046351 disaccharide biosynthetic process(GO:0046351)
0.3 3.9 GO:0046325 negative regulation of glucose import(GO:0046325)
0.3 1.0 GO:0002949 tRNA threonylcarbamoyladenosine modification(GO:0002949)
0.3 2.9 GO:2000778 positive regulation of interleukin-6 secretion(GO:2000778)
0.3 13.8 GO:0006953 acute-phase response(GO:0006953)
0.3 29.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.3 4.1 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 0.3 GO:0034136 negative regulation of toll-like receptor 2 signaling pathway(GO:0034136)
0.3 1.8 GO:0045198 establishment of epithelial cell apical/basal polarity(GO:0045198)
0.3 3.3 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.3 8.3 GO:0006099 tricarboxylic acid cycle(GO:0006099)
0.3 1.5 GO:0044351 macropinocytosis(GO:0044351)
0.3 2.0 GO:0006517 protein deglycosylation(GO:0006517)
0.3 1.5 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.3 2.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.3 12.4 GO:0030500 regulation of bone mineralization(GO:0030500)
0.3 1.4 GO:0071233 cellular response to leucine(GO:0071233)
0.3 0.5 GO:1904578 response to thapsigargin(GO:1904578) cellular response to thapsigargin(GO:1904579)
0.3 8.1 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 20.5 GO:0048706 embryonic skeletal system development(GO:0048706)
0.3 3.5 GO:0001702 gastrulation with mouth forming second(GO:0001702)
0.3 0.8 GO:0071031 nuclear mRNA surveillance of mRNA 3'-end processing(GO:0071031) nuclear polyadenylation-dependent tRNA catabolic process(GO:0071038) nuclear retention of pre-mRNA with aberrant 3'-ends at the site of transcription(GO:0071049)
0.3 1.0 GO:0009649 entrainment of circadian clock(GO:0009649)
0.3 2.8 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.2 10.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.2 4.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 6.2 GO:0048538 thymus development(GO:0048538)
0.2 2.1 GO:0060211 regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060211) positive regulation of nuclear-transcribed mRNA poly(A) tail shortening(GO:0060213)
0.2 1.4 GO:0071918 urea transmembrane transport(GO:0071918)
0.2 21.0 GO:0048678 response to axon injury(GO:0048678)
0.2 2.5 GO:0019432 triglyceride biosynthetic process(GO:0019432)
0.2 2.0 GO:0006983 ER overload response(GO:0006983)
0.2 15.1 GO:0043473 pigmentation(GO:0043473)
0.2 6.3 GO:0006024 glycosaminoglycan biosynthetic process(GO:0006024)
0.2 0.9 GO:0015936 coenzyme A metabolic process(GO:0015936)
0.2 5.0 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.2 0.9 GO:1902775 mitochondrial large ribosomal subunit assembly(GO:1902775)
0.2 12.4 GO:0030177 positive regulation of Wnt signaling pathway(GO:0030177)
0.2 2.1 GO:0031340 positive regulation of vesicle fusion(GO:0031340)
0.2 3.4 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.2 0.8 GO:0033326 cerebrospinal fluid secretion(GO:0033326)
0.2 9.6 GO:0043966 histone H3 acetylation(GO:0043966)
0.2 26.5 GO:0042113 B cell activation(GO:0042113)
0.2 3.5 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.2 2.3 GO:0046457 prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457)
0.2 0.6 GO:0045792 negative regulation of cell size(GO:0045792)
0.2 0.7 GO:0010138 pyrimidine ribonucleotide salvage(GO:0010138) pyrimidine nucleotide salvage(GO:0032262) UMP salvage(GO:0044206)
0.2 8.0 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.2 2.9 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.2 5.3 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.2 0.5 GO:0097498 endothelial tube lumen extension(GO:0097498)
0.2 3.9 GO:0072676 lymphocyte migration(GO:0072676)
0.2 1.2 GO:0002063 chondrocyte development(GO:0002063)
0.2 1.2 GO:1904294 positive regulation of ERAD pathway(GO:1904294)
0.2 4.7 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.2 0.3 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.2 5.7 GO:0097421 liver regeneration(GO:0097421)
0.2 4.8 GO:0070936 protein K48-linked ubiquitination(GO:0070936)
0.2 6.2 GO:0032945 negative regulation of mononuclear cell proliferation(GO:0032945) negative regulation of lymphocyte proliferation(GO:0050672)
0.2 0.5 GO:0035606 peptidyl-cysteine S-trans-nitrosylation(GO:0035606)
0.2 2.9 GO:0030033 microvillus assembly(GO:0030033)
0.2 1.4 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.2 2.3 GO:0000132 establishment of mitotic spindle orientation(GO:0000132)
0.2 7.1 GO:2000181 negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181)
0.2 9.9 GO:1902476 chloride transmembrane transport(GO:1902476)
0.1 1.0 GO:0007256 activation of JNKK activity(GO:0007256)
0.1 3.8 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 3.9 GO:0006801 superoxide metabolic process(GO:0006801)
0.1 0.7 GO:0003360 brainstem development(GO:0003360)
0.1 1.1 GO:0035067 negative regulation of histone acetylation(GO:0035067)
0.1 1.3 GO:0070070 proton-transporting V-type ATPase complex assembly(GO:0070070)
0.1 1.1 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.1 6.7 GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625)
0.1 0.5 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
0.1 2.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.1 4.8 GO:0019915 lipid storage(GO:0019915)
0.1 0.9 GO:0043686 co-translational protein modification(GO:0043686)
0.1 1.8 GO:0009060 aerobic respiration(GO:0009060)
0.1 48.4 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 3.6 GO:0070527 platelet aggregation(GO:0070527)
0.1 2.1 GO:0000154 rRNA modification(GO:0000154)
0.1 1.6 GO:0042407 cristae formation(GO:0042407)
0.1 0.1 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.1 0.4 GO:0014842 regulation of skeletal muscle satellite cell proliferation(GO:0014842)
0.1 1.7 GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846)
0.1 15.8 GO:0006486 protein glycosylation(GO:0006486) macromolecule glycosylation(GO:0043413)
0.1 1.0 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.1 0.6 GO:0002943 tRNA dihydrouridine synthesis(GO:0002943)
0.1 1.9 GO:1902235 regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902235)
0.1 1.8 GO:0002385 organ or tissue specific immune response(GO:0002251) mucosal immune response(GO:0002385)
0.1 0.4 GO:0090367 negative regulation of mRNA modification(GO:0090367)
0.1 6.1 GO:0009408 response to heat(GO:0009408)
0.1 0.7 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.1 2.6 GO:0018345 protein palmitoylation(GO:0018345)
0.1 1.0 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 0.2 GO:0006045 N-acetylglucosamine biosynthetic process(GO:0006045) N-acetylneuraminate biosynthetic process(GO:0046380) glucosamine-containing compound biosynthetic process(GO:1901073)
0.1 3.1 GO:0033138 positive regulation of peptidyl-serine phosphorylation(GO:0033138)
0.1 5.2 GO:0008344 adult locomotory behavior(GO:0008344)
0.1 2.0 GO:0000245 spliceosomal complex assembly(GO:0000245)
0.1 4.8 GO:0030217 T cell differentiation(GO:0030217)
0.1 0.9 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 1.8 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.1 5.6 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 0.3 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.1 0.8 GO:0032288 myelin assembly(GO:0032288)
0.1 2.5 GO:0045445 myoblast differentiation(GO:0045445)
0.1 0.9 GO:0043267 negative regulation of potassium ion transport(GO:0043267)
0.1 1.5 GO:1904031 positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.1 0.2 GO:0007000 nucleolus organization(GO:0007000)
0.1 0.9 GO:0061515 myeloid cell development(GO:0061515)
0.1 4.7 GO:0071773 response to BMP(GO:0071772) cellular response to BMP stimulus(GO:0071773)
0.1 0.4 GO:0072520 seminiferous tubule development(GO:0072520)
0.1 0.4 GO:0060736 prostate gland growth(GO:0060736)
0.0 1.3 GO:0006893 Golgi to plasma membrane transport(GO:0006893)
0.0 1.5 GO:0042220 response to cocaine(GO:0042220)
0.0 0.5 GO:0035902 response to immobilization stress(GO:0035902)
0.0 0.6 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.0 1.1 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 3.2 GO:0006818 hydrogen transport(GO:0006818)
0.0 6.4 GO:0010038 response to metal ion(GO:0010038)
0.0 1.6 GO:0008286 insulin receptor signaling pathway(GO:0008286)
0.0 1.7 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.3 GO:0021554 optic nerve development(GO:0021554)
0.0 0.5 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.3 GO:0051443 positive regulation of ubiquitin-protein transferase activity(GO:0051443)
0.0 0.8 GO:0030490 maturation of SSU-rRNA(GO:0030490)
0.0 0.5 GO:0048747 muscle fiber development(GO:0048747)
0.0 0.3 GO:0010107 potassium ion import(GO:0010107)
0.0 0.1 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 0.7 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
13.0 64.8 GO:0005927 muscle tendon junction(GO:0005927)
9.9 39.7 GO:0061474 phagolysosome membrane(GO:0061474)
5.4 37.8 GO:0071986 Ragulator complex(GO:0071986)
5.2 15.6 GO:0005899 insulin receptor complex(GO:0005899)
5.1 15.2 GO:1990796 photoreceptor cell terminal bouton(GO:1990796)
4.7 23.6 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
4.2 42.2 GO:0005641 nuclear envelope lumen(GO:0005641)
4.2 29.1 GO:0097136 Bcl-2 family protein complex(GO:0097136)
3.7 14.9 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
3.4 16.9 GO:0097413 Lewy body(GO:0097413)
3.4 16.8 GO:0046696 lipopolysaccharide receptor complex(GO:0046696)
3.3 36.0 GO:0097418 neurofibrillary tangle(GO:0097418)
3.0 11.8 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
2.9 37.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
2.8 11.2 GO:0045273 respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281)
2.7 21.8 GO:0000243 commitment complex(GO:0000243)
2.7 26.8 GO:0043020 NADPH oxidase complex(GO:0043020)
2.6 18.2 GO:0000322 storage vacuole(GO:0000322)
2.5 15.1 GO:0005879 axonemal microtubule(GO:0005879)
2.5 32.5 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
2.3 18.3 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
2.2 8.7 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
2.1 17.2 GO:0097452 GAIT complex(GO:0097452)
2.0 4.1 GO:0097629 extrinsic component of omegasome membrane(GO:0097629)
2.0 19.7 GO:0042587 glycogen granule(GO:0042587)
2.0 25.5 GO:0016342 catenin complex(GO:0016342)
1.9 21.2 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
1.9 17.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
1.9 11.4 GO:0071817 MMXD complex(GO:0071817)
1.7 3.5 GO:0030906 retromer, cargo-selective complex(GO:0030906)
1.7 13.7 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
1.7 8.5 GO:0097169 IPAF inflammasome complex(GO:0072557) AIM2 inflammasome complex(GO:0097169)
1.6 18.0 GO:0042555 MCM complex(GO:0042555)
1.6 7.9 GO:0031085 BLOC-3 complex(GO:0031085)
1.6 9.4 GO:0070765 gamma-secretase complex(GO:0070765)
1.6 14.0 GO:0033263 CORVET complex(GO:0033263)
1.5 3.1 GO:1990590 ATF1-ATF4 transcription factor complex(GO:1990590)
1.5 13.7 GO:0031082 BLOC complex(GO:0031082)
1.5 6.0 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
1.5 6.0 GO:0044393 TCR signalosome(GO:0036398) microspike(GO:0044393)
1.4 4.3 GO:1990723 cytoplasmic periphery of the nuclear pore complex(GO:1990723)
1.4 10.9 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
1.4 8.2 GO:0030896 checkpoint clamp complex(GO:0030896)
1.3 3.9 GO:0033557 Slx1-Slx4 complex(GO:0033557)
1.3 6.3 GO:0061689 tricellular tight junction(GO:0061689)
1.2 6.2 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.2 13.6 GO:0005797 Golgi medial cisterna(GO:0005797)
1.2 8.4 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
1.2 14.1 GO:0030008 TRAPP complex(GO:0030008)
1.2 620.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.2 15.0 GO:0030904 retromer complex(GO:0030904)
1.2 4.6 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
1.1 3.2 GO:1990826 nucleoplasmic periphery of the nuclear pore complex(GO:1990826)
1.1 34.0 GO:0005721 pericentric heterochromatin(GO:0005721)
1.0 3.1 GO:0031510 SUMO activating enzyme complex(GO:0031510)
1.0 3.1 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.0 13.3 GO:0035253 ciliary rootlet(GO:0035253)
1.0 4.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
1.0 11.8 GO:0005662 DNA replication factor A complex(GO:0005662)
1.0 2.9 GO:0005960 glycine cleavage complex(GO:0005960)
1.0 10.5 GO:0032541 cortical endoplasmic reticulum(GO:0032541)
0.9 91.6 GO:0016605 PML body(GO:0016605)
0.9 11.5 GO:0044666 MLL3/4 complex(GO:0044666)
0.9 7.0 GO:0001940 male pronucleus(GO:0001940)
0.9 6.1 GO:0005827 polar microtubule(GO:0005827)
0.9 7.7 GO:0000813 ESCRT I complex(GO:0000813)
0.8 6.4 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.8 7.2 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.8 3.2 GO:1990630 IRE1-RACK1-PP2A complex(GO:1990630)
0.8 5.4 GO:0030981 cortical microtubule cytoskeleton(GO:0030981)
0.8 20.9 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.8 2.3 GO:0071149 TEAD-1-YAP complex(GO:0071148) TEAD-2-YAP complex(GO:0071149)
0.7 11.2 GO:0000153 cytoplasmic ubiquitin ligase complex(GO:0000153)
0.7 5.0 GO:0098797 plasma membrane protein complex(GO:0098797)
0.7 2.1 GO:0061673 mitotic spindle astral microtubule(GO:0061673)
0.7 3.4 GO:0005947 mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947)
0.7 10.3 GO:0032591 dendritic spine membrane(GO:0032591)
0.7 4.7 GO:0042382 paraspeckles(GO:0042382)
0.7 8.7 GO:0030914 STAGA complex(GO:0030914)
0.7 5.3 GO:0065010 extracellular membrane-bounded organelle(GO:0065010)
0.7 13.8 GO:0031528 microvillus membrane(GO:0031528)
0.6 9.5 GO:0035102 PRC1 complex(GO:0035102)
0.6 15.8 GO:0032839 dendrite cytoplasm(GO:0032839)
0.6 3.6 GO:0001651 dense fibrillar component(GO:0001651)
0.6 4.8 GO:0042613 MHC class II protein complex(GO:0042613)
0.6 3.0 GO:0048179 activin receptor complex(GO:0048179)
0.6 1.8 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.6 1.8 GO:0045203 intrinsic component of cell outer membrane(GO:0031230) integral component of cell outer membrane(GO:0045203)
0.6 37.0 GO:0000792 heterochromatin(GO:0000792)
0.6 2.9 GO:0005642 annulate lamellae(GO:0005642)
0.6 9.6 GO:0005685 U1 snRNP(GO:0005685)
0.6 7.8 GO:0001891 phagocytic cup(GO:0001891)
0.5 15.9 GO:0001772 immunological synapse(GO:0001772)
0.5 37.1 GO:0030136 clathrin-coated vesicle(GO:0030136)
0.5 33.7 GO:1903293 phosphatase complex(GO:1903293)
0.5 12.9 GO:0000242 pericentriolar material(GO:0000242)
0.5 33.5 GO:0005811 lipid particle(GO:0005811)
0.5 75.6 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.5 8.6 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.5 26.2 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.5 1.5 GO:0030956 glutamyl-tRNA(Gln) amidotransferase complex(GO:0030956)
0.5 2.0 GO:0071010 prespliceosome(GO:0071010)
0.5 1.5 GO:0005818 astral microtubule(GO:0000235) aster(GO:0005818)
0.5 1.5 GO:0045025 mitochondrial degradosome(GO:0045025)
0.5 5.2 GO:0035631 CD40 receptor complex(GO:0035631)
0.5 9.3 GO:0016460 myosin II complex(GO:0016460)
0.5 18.6 GO:0009925 basal plasma membrane(GO:0009925)
0.5 31.5 GO:0031526 brush border membrane(GO:0031526)
0.5 5.0 GO:0044294 dendritic growth cone(GO:0044294)
0.4 33.4 GO:0005770 late endosome(GO:0005770)
0.4 1.3 GO:0044308 axonal spine(GO:0044308)
0.4 9.2 GO:0035371 microtubule plus-end(GO:0035371)
0.4 4.5 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.4 2.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.4 7.4 GO:0031430 M band(GO:0031430)
0.4 17.8 GO:0005776 autophagosome(GO:0005776)
0.4 7.6 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.4 24.9 GO:0005901 caveola(GO:0005901)
0.4 17.1 GO:0005871 kinesin complex(GO:0005871)
0.4 14.1 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.4 1.8 GO:0070761 pre-snoRNP complex(GO:0070761)
0.3 15.0 GO:0045171 intercellular bridge(GO:0045171)
0.3 7.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 2.8 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.3 8.6 GO:0035145 exon-exon junction complex(GO:0035145)
0.3 4.8 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.3 2.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 1.9 GO:0042788 polysomal ribosome(GO:0042788)
0.3 1.2 GO:0042405 nuclear inclusion body(GO:0042405)
0.3 1.5 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.3 4.6 GO:0030126 COPI vesicle coat(GO:0030126)
0.3 42.2 GO:0005681 spliceosomal complex(GO:0005681)
0.3 0.6 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.3 7.0 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.3 25.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.3 2.4 GO:0099634 postsynaptic specialization membrane(GO:0099634)
0.3 5.3 GO:0005614 interstitial matrix(GO:0005614)
0.3 30.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.3 0.8 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 3.9 GO:0044217 other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.3 0.5 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3 11.2 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.3 3.3 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
0.3 58.4 GO:0031965 nuclear membrane(GO:0031965)
0.2 1.0 GO:0000408 EKC/KEOPS complex(GO:0000408)
0.2 3.4 GO:0000346 transcription export complex(GO:0000346)
0.2 22.1 GO:0005769 early endosome(GO:0005769)
0.2 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.2 11.4 GO:0005657 replication fork(GO:0005657)
0.2 1.1 GO:0008024 cyclin/CDK positive transcription elongation factor complex(GO:0008024)
0.2 1.6 GO:0061617 MICOS complex(GO:0061617)
0.2 7.6 GO:0060077 inhibitory synapse(GO:0060077)
0.2 0.9 GO:0042824 MHC class I peptide loading complex(GO:0042824)
0.2 0.8 GO:0044615 nuclear pore nuclear basket(GO:0044615)
0.2 24.9 GO:0001650 fibrillar center(GO:0001650)
0.2 2.4 GO:0030666 endocytic vesicle membrane(GO:0030666)
0.2 5.1 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 100.7 GO:0016604 nuclear body(GO:0016604)
0.2 9.5 GO:0031903 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.2 11.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.2 0.6 GO:0031931 TORC1 complex(GO:0031931)
0.2 11.3 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 2.0 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 17.3 GO:0032993 protein-DNA complex(GO:0032993)
0.2 27.7 GO:0005925 focal adhesion(GO:0005925)
0.2 9.2 GO:0005581 collagen trimer(GO:0005581)
0.2 0.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
0.2 2.7 GO:0016459 myosin complex(GO:0016459)
0.2 4.3 GO:0070382 exocytic vesicle(GO:0070382)
0.2 1.1 GO:0005652 nuclear lamina(GO:0005652)
0.2 62.8 GO:0005740 mitochondrial envelope(GO:0005740)
0.1 0.7 GO:0045098 type III intermediate filament(GO:0045098)
0.1 2.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 5.4 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.1 326.0 GO:0070062 extracellular exosome(GO:0070062)
0.1 3.8 GO:0005768 endosome(GO:0005768)
0.1 4.0 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 36.3 GO:0000139 Golgi membrane(GO:0000139)
0.1 4.2 GO:0055037 recycling endosome(GO:0055037)
0.1 4.4 GO:0005774 vacuolar membrane(GO:0005774)
0.1 1.7 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 3.2 GO:0015935 small ribosomal subunit(GO:0015935)
0.1 1.4 GO:0031672 A band(GO:0031672)
0.1 1.7 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 2.6 GO:0097060 synaptic membrane(GO:0097060)
0.1 3.4 GO:0005840 ribosome(GO:0005840)
0.1 1.3 GO:0000780 condensed nuclear chromosome, centromeric region(GO:0000780)
0.1 1.7 GO:0005604 basement membrane(GO:0005604)
0.1 0.9 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 1.7 GO:0030686 90S preribosome(GO:0030686)
0.1 0.9 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.1 24.4 GO:0005730 nucleolus(GO:0005730)
0.1 1.7 GO:0098802 plasma membrane receptor complex(GO:0098802)
0.1 3.3 GO:0001726 ruffle(GO:0001726)
0.1 1.2 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 12.9 GO:0000785 chromatin(GO:0000785)
0.1 0.4 GO:0046930 pore complex(GO:0046930)
0.0 2.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0031045 dense core granule(GO:0031045)
0.0 30.0 GO:0005739 mitochondrion(GO:0005739)
0.0 16.4 GO:0030054 cell junction(GO:0030054)
0.0 4.1 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 108.0 GO:0016021 integral component of membrane(GO:0016021)
0.0 2.3 GO:0016324 apical plasma membrane(GO:0016324)
0.0 14.8 GO:0005783 endoplasmic reticulum(GO:0005783)
0.0 0.2 GO:0045177 apical part of cell(GO:0045177)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
31.3 125.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
14.9 59.6 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
13.4 53.5 GO:0030984 kininogen binding(GO:0030984)
12.0 36.0 GO:0004724 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724)
8.6 25.9 GO:0004370 glycerol kinase activity(GO:0004370)
7.9 23.6 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
7.9 23.6 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
7.3 22.0 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
6.5 19.5 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
6.3 6.3 GO:0070506 high-density lipoprotein particle receptor activity(GO:0070506)
6.2 18.7 GO:0008948 oxaloacetate decarboxylase activity(GO:0008948) hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823)
6.1 18.2 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
5.9 29.4 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
5.7 17.0 GO:0031871 proteinase activated receptor binding(GO:0031871)
5.3 26.4 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
5.3 47.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
5.1 40.9 GO:0016936 galactoside binding(GO:0016936)
5.0 40.3 GO:0031419 cobalamin binding(GO:0031419)
4.6 27.8 GO:0051434 BH3 domain binding(GO:0051434)
4.6 13.7 GO:1990460 leptin receptor binding(GO:1990460)
4.5 18.1 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
4.5 35.8 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
4.4 13.3 GO:0001069 regulatory region RNA binding(GO:0001069)
4.3 17.0 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
4.2 12.5 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
4.1 37.3 GO:0005072 transforming growth factor beta receptor, cytoplasmic mediator activity(GO:0005072)
4.1 20.6 GO:0004945 angiotensin type II receptor activity(GO:0004945)
3.9 19.5 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
3.5 31.9 GO:0032050 clathrin heavy chain binding(GO:0032050)
3.5 66.9 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
3.5 24.4 GO:0033592 RNA strand annealing activity(GO:0033592)
3.4 13.7 GO:0005163 nerve growth factor receptor binding(GO:0005163)
3.4 16.8 GO:0034186 apolipoprotein A-I binding(GO:0034186)
3.3 10.0 GO:1990050 phosphatidic acid transporter activity(GO:1990050)
3.2 38.2 GO:0015379 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
3.1 24.6 GO:0008430 selenium binding(GO:0008430)
3.0 12.2 GO:0071558 histone demethylase activity (H3-K27 specific)(GO:0071558)
2.8 17.0 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
2.8 11.2 GO:0000104 succinate dehydrogenase activity(GO:0000104)
2.8 11.2 GO:0019776 Atg8 ligase activity(GO:0019776)
2.8 13.8 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
2.7 21.3 GO:0045545 syndecan binding(GO:0045545)
2.6 10.4 GO:0004949 cannabinoid receptor activity(GO:0004949)
2.5 7.6 GO:0005302 L-tyrosine transmembrane transporter activity(GO:0005302)
2.5 27.9 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
2.5 4.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
2.5 12.3 GO:0019770 IgG receptor activity(GO:0019770)
2.4 9.7 GO:0016833 oxo-acid-lyase activity(GO:0016833)
2.4 26.1 GO:0042577 lipid phosphatase activity(GO:0042577)
2.3 9.4 GO:0035614 snRNA stem-loop binding(GO:0035614)
2.3 7.0 GO:0005119 smoothened binding(GO:0005119)
2.3 16.2 GO:0031852 mu-type opioid receptor binding(GO:0031852)
2.3 20.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
2.2 17.5 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
2.2 15.1 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
2.1 6.2 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
2.0 20.1 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.0 11.8 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
1.9 5.7 GO:0008476 protein-tyrosine sulfotransferase activity(GO:0008476)
1.9 11.5 GO:0030976 thiamine pyrophosphate binding(GO:0030976)
1.9 9.5 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
1.8 14.7 GO:0031386 protein tag(GO:0031386)
1.8 9.2 GO:0008499 UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499)
1.8 7.3 GO:0015184 L-cystine transmembrane transporter activity(GO:0015184)
1.8 10.9 GO:0042289 MHC class II protein binding(GO:0042289)
1.8 32.6 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
1.8 7.2 GO:0052794 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
1.8 5.3 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
1.7 7.0 GO:0070579 methylcytosine dioxygenase activity(GO:0070579)
1.7 6.9 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
1.7 6.8 GO:0005534 galactose binding(GO:0005534)
1.7 13.4 GO:0035184 histone threonine kinase activity(GO:0035184)
1.7 5.0 GO:0017042 glycosylceramidase activity(GO:0017042)
1.6 8.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
1.6 6.4 GO:1904288 BAT3 complex binding(GO:1904288)
1.6 4.8 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.6 14.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
1.6 4.8 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
1.6 9.4 GO:0001849 complement component C1q binding(GO:0001849)
1.6 15.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
1.6 4.7 GO:0031432 titin binding(GO:0031432)
1.5 7.6 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
1.4 11.4 GO:0046527 glucosyltransferase activity(GO:0046527)
1.4 4.2 GO:0004911 interleukin-2 receptor activity(GO:0004911)
1.4 16.9 GO:0019911 structural constituent of myelin sheath(GO:0019911)
1.4 4.2 GO:0003976 UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity(GO:0003976)
1.4 25.1 GO:0015279 store-operated calcium channel activity(GO:0015279)
1.4 15.2 GO:0050544 arachidonic acid binding(GO:0050544)
1.4 31.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
1.3 24.1 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.3 19.0 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
1.3 12.6 GO:0008484 sulfuric ester hydrolase activity(GO:0008484)
1.3 2.5 GO:0004698 calcium-dependent protein kinase C activity(GO:0004698)
1.2 3.7 GO:0004574 oligo-1,6-glucosidase activity(GO:0004574)
1.2 13.7 GO:0005346 adenine nucleotide transmembrane transporter activity(GO:0000295) purine ribonucleotide transmembrane transporter activity(GO:0005346)
1.2 9.9 GO:0016421 CoA carboxylase activity(GO:0016421)
1.2 9.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
1.2 7.2 GO:0046624 sphingolipid transporter activity(GO:0046624)
1.2 6.0 GO:0097016 L27 domain binding(GO:0097016)
1.2 7.2 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
1.2 30.0 GO:0008198 ferrous iron binding(GO:0008198)
1.2 4.8 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
1.2 21.1 GO:0044548 S100 protein binding(GO:0044548)
1.1 11.5 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
1.1 21.3 GO:0016881 acid-amino acid ligase activity(GO:0016881)
1.1 8.9 GO:0005168 neurotrophin TRKA receptor binding(GO:0005168)
1.1 8.7 GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity(GO:0016308)
1.1 23.5 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
1.1 48.0 GO:0048365 Rac GTPase binding(GO:0048365)
1.1 8.5 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.1 6.4 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
1.1 50.9 GO:0019213 deacetylase activity(GO:0019213)
1.1 11.6 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161)
1.0 3.1 GO:0044388 small protein activating enzyme binding(GO:0044388)
1.0 9.4 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
1.0 7.2 GO:0008603 cAMP-dependent protein kinase regulator activity(GO:0008603)
1.0 4.1 GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity(GO:0003831)
1.0 4.1 GO:0004594 pantothenate kinase activity(GO:0004594)
1.0 6.0 GO:0043426 MRF binding(GO:0043426)
1.0 1.0 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
1.0 3.0 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.0 14.7 GO:0009982 pseudouridine synthase activity(GO:0009982)
1.0 2.9 GO:0004159 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
1.0 4.9 GO:0034597 phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
1.0 21.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
1.0 41.6 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
1.0 3.8 GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity(GO:0030144)
1.0 2.9 GO:0051425 PTB domain binding(GO:0051425)
0.9 10.4 GO:0003708 retinoic acid receptor activity(GO:0003708)
0.9 4.7 GO:0001042 RNA polymerase I core binding(GO:0001042)
0.9 12.3 GO:0042609 CD4 receptor binding(GO:0042609)
0.9 17.9 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.9 20.5 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)
0.9 2.8 GO:0004736 pyruvate carboxylase activity(GO:0004736)
0.9 2.8 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.9 5.4 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.9 10.0 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.9 6.3 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.9 7.1 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.9 7.1 GO:0003680 AT DNA binding(GO:0003680)
0.9 6.2 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.9 7.0 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
0.9 6.0 GO:0098599 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.8 4.2 GO:0015166 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
0.8 4.9 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.8 11.5 GO:0008373 sialyltransferase activity(GO:0008373)
0.8 7.3 GO:0015232 heme transporter activity(GO:0015232)
0.8 20.9 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.8 3.2 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
0.8 38.2 GO:0005507 copper ion binding(GO:0005507)
0.8 9.3 GO:0070700 BMP receptor binding(GO:0070700)
0.8 8.5 GO:0097200 cysteine-type endopeptidase activity involved in apoptotic process(GO:0097153) cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:0097200)
0.8 7.7 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.8 23.9 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.8 1.5 GO:0050567 glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity(GO:0050567)
0.8 4.5 GO:0070403 NAD+ binding(GO:0070403)
0.8 16.5 GO:0008327 methyl-CpG binding(GO:0008327)
0.8 36.8 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
0.7 15.3 GO:0005521 lamin binding(GO:0005521)
0.7 3.6 GO:0044547 DNA topoisomerase binding(GO:0044547)
0.7 10.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.7 10.0 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.7 12.1 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.7 3.5 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.7 2.7 GO:0050693 LBD domain binding(GO:0050693)
0.7 30.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.7 6.1 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.7 5.3 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.7 26.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.7 6.0 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
0.7 48.2 GO:0032947 protein complex scaffold(GO:0032947)
0.6 9.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.6 10.2 GO:0017166 vinculin binding(GO:0017166)
0.6 2.5 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.6 8.2 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.6 8.1 GO:0003796 lysozyme activity(GO:0003796)
0.6 1.2 GO:0051538 3 iron, 4 sulfur cluster binding(GO:0051538)
0.6 4.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.6 22.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.6 1.8 GO:0004582 dolichyl-phosphate beta-D-mannosyltransferase activity(GO:0004582)
0.6 2.9 GO:0031994 insulin-like growth factor I binding(GO:0031994) neuregulin binding(GO:0038132)
0.6 5.3 GO:0015250 water channel activity(GO:0015250)
0.6 4.1 GO:0019238 cyclohydrolase activity(GO:0019238)
0.6 1.7 GO:0009041 uridylate kinase activity(GO:0009041) nucleoside phosphate kinase activity(GO:0050145)
0.6 2.9 GO:0042608 T cell receptor binding(GO:0042608)
0.6 26.4 GO:1901476 carbohydrate transmembrane transporter activity(GO:0015144) carbohydrate transporter activity(GO:1901476)
0.6 9.2 GO:0031005 filamin binding(GO:0031005)
0.6 15.5 GO:0036002 pre-mRNA binding(GO:0036002)
0.6 3.4 GO:0016624 oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor(GO:0016624)
0.6 7.3 GO:0003688 DNA replication origin binding(GO:0003688)
0.6 6.2 GO:0071837 HMG box domain binding(GO:0071837)
0.5 18.7 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.5 11.0 GO:0000030 mannosyltransferase activity(GO:0000030)
0.5 3.7 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
0.5 2.7 GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors(GO:0016661)
0.5 39.5 GO:0003727 single-stranded RNA binding(GO:0003727)
0.5 12.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.5 6.4 GO:1990405 protein antigen binding(GO:1990405)
0.5 3.7 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.5 2.5 GO:0090554 phosphatidylcholine-translocating ATPase activity(GO:0090554) phosphatidylethanolamine-translocating ATPase activity(GO:0090555)
0.5 1.5 GO:0009384 N-acylmannosamine kinase activity(GO:0009384)
0.5 2.5 GO:0032051 clathrin light chain binding(GO:0032051)
0.5 4.0 GO:0043495 protein anchor(GO:0043495)
0.5 1.5 GO:0045340 mercury ion binding(GO:0045340)
0.5 2.5 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.5 4.0 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.5 144.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.5 12.7 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.5 28.8 GO:0016667 oxidoreductase activity, acting on a sulfur group of donors(GO:0016667)
0.5 55.4 GO:0017124 SH3 domain binding(GO:0017124)
0.5 20.9 GO:0005080 protein kinase C binding(GO:0005080)
0.5 9.5 GO:0005158 insulin receptor binding(GO:0005158)
0.5 3.3 GO:0015119 hexose phosphate transmembrane transporter activity(GO:0015119) organophosphate:inorganic phosphate antiporter activity(GO:0015315) hexose-phosphate:inorganic phosphate antiporter activity(GO:0015526) glucose 6-phosphate:inorganic phosphate antiporter activity(GO:0061513)
0.5 1.4 GO:0004661 protein geranylgeranyltransferase activity(GO:0004661)
0.5 1.9 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.5 6.9 GO:0036442 hydrogen-exporting ATPase activity(GO:0036442)
0.5 25.7 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.4 3.6 GO:0051400 BH domain binding(GO:0051400)
0.4 10.3 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.4 13.4 GO:0008536 Ran GTPase binding(GO:0008536)
0.4 12.6 GO:0019200 carbohydrate kinase activity(GO:0019200)
0.4 9.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.4 1.3 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.4 1.3 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
0.4 2.9 GO:0017070 U6 snRNA binding(GO:0017070)
0.4 2.9 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.4 19.5 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.4 1.2 GO:0008254 3'-nucleotidase activity(GO:0008254)
0.4 2.5 GO:0008172 S-methyltransferase activity(GO:0008172)
0.4 1.2 GO:0016748 succinyltransferase activity(GO:0016748)
0.4 3.5 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
0.4 7.1 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.4 6.2 GO:0008253 5'-nucleotidase activity(GO:0008253)
0.4 2.7 GO:0032554 purine deoxyribonucleotide binding(GO:0032554)
0.4 1.9 GO:1990226 histone methyltransferase binding(GO:1990226)
0.4 11.8 GO:0005504 fatty acid binding(GO:0005504)
0.4 3.3 GO:0043295 glutathione binding(GO:0043295)
0.4 2.9 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 35.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.4 2.5 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.4 2.8 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 3.9 GO:0048185 activin binding(GO:0048185)
0.3 1.0 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.3 5.2 GO:0031996 thioesterase binding(GO:0031996)
0.3 9.6 GO:0008378 galactosyltransferase activity(GO:0008378)
0.3 2.4 GO:0034185 apolipoprotein binding(GO:0034185)
0.3 15.8 GO:0051287 NAD binding(GO:0051287)
0.3 4.0 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.3 15.1 GO:0019894 kinesin binding(GO:0019894)
0.3 1.2 GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity(GO:0035242)
0.3 14.5 GO:0004521 endoribonuclease activity(GO:0004521)
0.3 5.8 GO:0051010 microtubule plus-end binding(GO:0051010)
0.3 3.3 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 0.9 GO:0046978 TAP binding(GO:0046977) TAP1 binding(GO:0046978) TAP2 binding(GO:0046979)
0.3 3.7 GO:0042043 neurexin family protein binding(GO:0042043)
0.3 1.4 GO:0015204 urea transmembrane transporter activity(GO:0015204)
0.3 9.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.3 0.5 GO:0016882 cyclo-ligase activity(GO:0016882)
0.3 7.3 GO:0050699 WW domain binding(GO:0050699)
0.3 43.8 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.3 3.3 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.2 3.4 GO:0017154 semaphorin receptor activity(GO:0017154)
0.2 1.2 GO:0031685 adenosine receptor binding(GO:0031685)
0.2 18.9 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.2 9.3 GO:0030295 protein kinase activator activity(GO:0030295)
0.2 12.6 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 15.4 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.2 4.0 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.2 1.7 GO:0070087 chromo shadow domain binding(GO:0070087)
0.2 3.1 GO:0001671 ATPase activator activity(GO:0001671)
0.2 46.9 GO:0005096 GTPase activator activity(GO:0005096)
0.2 4.9 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 6.2 GO:0046332 SMAD binding(GO:0046332)
0.2 5.0 GO:0035258 steroid hormone receptor binding(GO:0035258)
0.2 9.4 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.2 10.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 2.9 GO:0042056 chemoattractant activity(GO:0042056)
0.2 1.9 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 97.0 GO:0003700 nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700)
0.2 2.0 GO:0016868 intramolecular transferase activity, phosphotransferases(GO:0016868)
0.2 1.3 GO:0016681 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.2 2.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.1 6.0 GO:0005484 SNAP receptor activity(GO:0005484)
0.1 0.6 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.1 21.6 GO:0005125 cytokine activity(GO:0005125)
0.1 2.3 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.3 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 2.0 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.1 0.8 GO:0030274 LIM domain binding(GO:0030274)
0.1 1.6 GO:0008097 5S rRNA binding(GO:0008097)
0.1 1.2 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.1 1.3 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.1 1.6 GO:0004697 protein kinase C activity(GO:0004697)
0.1 2.9 GO:0035254 glutamate receptor binding(GO:0035254)
0.1 1.3 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 10.2 GO:0030165 PDZ domain binding(GO:0030165)
0.1 1.8 GO:0017080 sodium channel regulator activity(GO:0017080)
0.1 1.4 GO:0004016 adenylate cyclase activity(GO:0004016) guanylate cyclase activity(GO:0004383)
0.1 2.8 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 1.2 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978)
0.1 1.9 GO:1901505 carbohydrate derivative transporter activity(GO:1901505)
0.1 2.3 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 0.5 GO:0001729 ceramide kinase activity(GO:0001729)
0.1 0.9 GO:0023026 MHC class II protein complex binding(GO:0023026)
0.1 0.6 GO:0017150 tRNA dihydrouridine synthase activity(GO:0017150)
0.1 3.3 GO:0005246 calcium channel regulator activity(GO:0005246)
0.1 3.7 GO:0008080 N-acetyltransferase activity(GO:0008080)
0.1 1.9 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.1 0.8 GO:0031748 D1 dopamine receptor binding(GO:0031748)
0.1 6.4 GO:0051219 phosphoprotein binding(GO:0051219)
0.1 15.5 GO:0000287 magnesium ion binding(GO:0000287)
0.1 1.6 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.1 4.1 GO:0051087 chaperone binding(GO:0051087)
0.1 0.6 GO:0047429 nucleoside-triphosphate diphosphatase activity(GO:0047429)
0.1 3.7 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 0.3 GO:0030622 U4 snRNA binding(GO:0030621) U4atac snRNA binding(GO:0030622)
0.1 1.0 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 8.9 GO:0051015 actin filament binding(GO:0051015)
0.1 11.5 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.1 2.6 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.1 20.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.1 1.3 GO:0015299 solute:proton antiporter activity(GO:0015299)
0.1 21.6 GO:0019904 protein domain specific binding(GO:0019904)
0.1 10.7 GO:0046906 tetrapyrrole binding(GO:0046906)
0.1 10.0 GO:0016874 ligase activity(GO:0016874)
0.1 2.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 0.9 GO:0016854 racemase and epimerase activity(GO:0016854)
0.1 0.9 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 1.5 GO:0001786 phosphatidylserine binding(GO:0001786)
0.1 5.7 GO:0004713 protein tyrosine kinase activity(GO:0004713)
0.1 1.6 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.1 11.7 GO:0003924 GTPase activity(GO:0003924)
0.1 3.4 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.1 0.4 GO:0008061 chitin binding(GO:0008061)
0.0 0.8 GO:0005112 Notch binding(GO:0005112)
0.0 1.7 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 3.0 GO:0004896 cytokine receptor activity(GO:0004896)
0.0 2.2 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.4 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.1 GO:0000703 oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity(GO:0000703)
0.0 1.0 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 2.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 2.5 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.6 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472)
0.0 0.7 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.2 GO:0005167 neurotrophin TRK receptor binding(GO:0005167)
0.0 0.1 GO:0019870 potassium channel inhibitor activity(GO:0019870) sodium channel inhibitor activity(GO:0019871)
0.0 1.7 GO:0016503 pheromone receptor activity(GO:0016503)
0.0 1.4 GO:0008201 heparin binding(GO:0008201)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 23.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
1.9 34.7 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.8 29.1 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
1.7 36.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
1.2 73.9 PID AP1 PATHWAY AP-1 transcription factor network
1.1 47.0 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
1.1 24.9 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
1.0 65.5 PID RAC1 PATHWAY RAC1 signaling pathway
1.0 9.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.9 8.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.9 20.0 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.9 23.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.9 36.6 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.8 25.5 PID ALK1 PATHWAY ALK1 signaling events
0.8 41.6 PID LKB1 PATHWAY LKB1 signaling events
0.8 18.9 PID MYC PATHWAY C-MYC pathway
0.8 30.8 PID ATR PATHWAY ATR signaling pathway
0.7 16.8 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.7 33.7 PID IL12 2PATHWAY IL12-mediated signaling events
0.7 11.8 PID LPA4 PATHWAY LPA4-mediated signaling events
0.7 14.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.7 5.2 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.6 143.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.6 15.7 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.5 14.7 PID GLYPICAN 1PATHWAY Glypican 1 network
0.5 17.6 PID ILK PATHWAY Integrin-linked kinase signaling
0.5 6.8 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.4 7.0 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.4 16.0 PID P53 REGULATION PATHWAY p53 pathway
0.4 1.6 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.4 11.3 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 9.0 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.4 19.4 PID RHOA REG PATHWAY Regulation of RhoA activity
0.4 8.9 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.3 34.3 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 6.0 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.3 4.3 PID IL1 PATHWAY IL1-mediated signaling events
0.3 9.3 PID P73PATHWAY p73 transcription factor network
0.3 10.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 11.1 PID BMP PATHWAY BMP receptor signaling
0.3 12.3 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 2.4 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 4.2 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.2 16.7 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.2 2.6 PID PI3K PLC TRK PATHWAY Trk receptor signaling mediated by PI3K and PLC-gamma
0.2 6.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.2 5.2 PID TGFBR PATHWAY TGF-beta receptor signaling
0.2 1.9 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.2 1.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 2.7 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 3.7 PID ATM PATHWAY ATM pathway
0.2 2.6 PID FAS PATHWAY FAS (CD95) signaling pathway
0.2 9.3 PID AR PATHWAY Coregulation of Androgen receptor activity
0.2 26.1 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 1.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.2 1.5 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.2 2.4 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.2 1.6 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 7.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.8 PID ENDOTHELIN PATHWAY Endothelins
0.1 4.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.3 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.1 5.0 PID AURORA B PATHWAY Aurora B signaling
0.1 2.8 PID INSULIN PATHWAY Insulin Pathway
0.1 2.2 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.9 ST G ALPHA I PATHWAY G alpha i Pathway
0.1 1.0 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 1.7 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.0 1.1 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.1 PID PI3KCI AKT PATHWAY Class I PI3K signaling events mediated by Akt
0.0 0.8 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 5.2 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 0.5 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.2 PID RHOA PATHWAY RhoA signaling pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 59.6 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
5.4 209.5 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
3.2 31.9 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
2.7 26.8 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
2.4 24.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
2.3 35.1 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
2.2 40.9 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
2.1 27.4 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
2.0 46.8 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
1.9 11.4 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
1.7 103.7 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
1.7 29.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
1.7 18.6 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
1.7 21.6 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
1.6 14.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
1.6 23.5 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
1.6 21.8 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
1.5 27.3 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
1.5 22.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
1.5 20.9 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
1.3 22.5 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.3 37.3 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
1.2 17.6 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
1.2 18.5 REACTOME SYNTHESIS OF SUBSTRATES IN N GLYCAN BIOSYTHESIS Genes involved in Synthesis of substrates in N-glycan biosythesis
1.1 14.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
1.1 8.9 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
1.1 12.1 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
1.1 30.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
1.1 18.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
1.1 12.8 REACTOME PYRUVATE METABOLISM AND CITRIC ACID TCA CYCLE Genes involved in Pyruvate metabolism and Citric Acid (TCA) cycle
1.1 20.2 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
1.0 9.9 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
1.0 4.9 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
1.0 9.5 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
0.9 19.0 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
0.9 6.4 REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE Genes involved in Translocation of ZAP-70 to Immunological synapse
0.9 34.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.9 12.4 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
0.8 31.3 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.8 9.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.8 11.0 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.8 13.3 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.8 29.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.8 22.1 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.8 4.6 REACTOME P53 INDEPENDENT G1 S DNA DAMAGE CHECKPOINT Genes involved in p53-Independent G1/S DNA damage checkpoint
0.7 87.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.6 6.4 REACTOME NEF MEDIATES DOWN MODULATION OF CELL SURFACE RECEPTORS BY RECRUITING THEM TO CLATHRIN ADAPTERS Genes involved in Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters
0.6 7.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.6 61.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.6 7.9 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.5 5.3 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
0.5 5.3 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 25.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.5 5.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 4.1 REACTOME ADP SIGNALLING THROUGH P2RY1 Genes involved in ADP signalling through P2Y purinoceptor 1
0.5 11.5 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.5 4.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.4 3.5 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.4 8.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.4 4.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 12.8 REACTOME KINESINS Genes involved in Kinesins
0.4 62.5 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.4 3.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.4 5.1 REACTOME ACTIVATION OF KAINATE RECEPTORS UPON GLUTAMATE BINDING Genes involved in Activation of Kainate Receptors upon glutamate binding
0.4 17.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.4 3.7 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.4 4.3 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.4 5.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.4 26.1 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.4 6.0 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
0.3 4.0 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.3 5.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.3 13.6 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
0.3 2.9 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.3 6.1 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 3.4 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
0.3 1.1 REACTOME HOST INTERACTIONS OF HIV FACTORS Genes involved in Host Interactions of HIV factors
0.3 9.6 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.3 2.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.3 2.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 4.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.2 2.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.2 8.0 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.2 9.7 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.2 8.9 REACTOME FATTY ACID TRIACYLGLYCEROL AND KETONE BODY METABOLISM Genes involved in Fatty acid, triacylglycerol, and ketone body metabolism
0.2 3.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.2 7.7 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 6.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 2.1 REACTOME RECRUITMENT OF NUMA TO MITOTIC CENTROSOMES Genes involved in Recruitment of NuMA to mitotic centrosomes
0.2 10.1 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.2 3.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.2 11.9 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.2 1.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 1.5 REACTOME SIGNALLING TO RAS Genes involved in Signalling to RAS
0.2 9.1 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 28.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.2 11.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 1.2 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 7.5 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 9.3 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.2 16.4 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.1 3.3 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 1.7 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 7.9 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 2.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.7 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.1 5.3 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 3.0 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 7.0 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.1 2.5 REACTOME G2 M CHECKPOINTS Genes involved in G2/M Checkpoints
0.1 1.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.1 3.3 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 2.1 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.0 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.1 6.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 1.1 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 1.2 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.1 0.9 REACTOME PLC BETA MEDIATED EVENTS Genes involved in PLC beta mediated events
0.1 1.6 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.1 2.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 0.3 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 1.4 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.4 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.0 1.7 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.3 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits