ISMARA results: Tfdp1_Wt1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfdp1_Wt1_Egr2

Z-value: 2.50

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Transcription factors associated with Tfdp1_Wt1_Egr2

Gene Symbol	Gene ID	Gene Info
Tfdp1 NCBI RGD Ensembl	ENSRNOG00000019222	transcription factor Dp-1
Wt1 NCBI RGD Ensembl	ENSRNOG00000013074	Wilms tumor 1
Egr2 NCBI RGD Ensembl	ENSRNOG00000000640	early growth response 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfdp1	rn6_v1_chr16_+_81089292_81089308	0.67	1.4e-43	Click!
Egr2	rn6_v1_chr20_-_22459025_22459025	0.36	5.8e-11	Click!
Wt1	rn6_v1_chr3_+_95133713_95133713	0.17	2.0e-03	Click!

Activity profile of Tfdp1_Wt1_Egr2 motif

Sorted Z-values of Tfdp1_Wt1_Egr2 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_86512797 Show fit	118.15	ENSRNOT00000051680	Gp1bb NCBI RGD Ensembl Show fit	glycoprotein Ib platelet beta subunit
chr6_+_44009872 Show fit	99.64	ENSRNOT00000082657	Mboat2 NCBI RGD Ensembl Show fit	membrane bound O-acyltransferase domain containing 2
chr14_+_87312203 Show fit	88.94	ENSRNOT00000088032	Adcy1 NCBI RGD Ensembl Show fit	adenylate cyclase 1
chr8_+_118333706 Show fit	87.64	ENSRNOT00000028278	Cspg5 NCBI RGD Ensembl Show fit	chondroitin sulfate proteoglycan 5
chr1_-_72727112 Show fit	86.16	ENSRNOT00000031172	Brsk1 NCBI RGD Ensembl Show fit	BR serine/threonine kinase 1
chr7_-_116607408 Show fit	83.07	ENSRNOT00000076009 ENSRNOT00000056554	Ly6h NCBI RGD Ensembl Show fit	lymphocyte antigen 6 complex, locus H
chr17_-_78962476 Show fit	77.41	ENSRNOT00000030228	Nmt2 NCBI RGD Ensembl Show fit	N-myristoyltransferase 2
chr19_+_52086325 Show fit	75.91	ENSRNOT00000020341	Necab2 NCBI RGD Ensembl Show fit	N-terminal EF-hand calcium binding protein 2
chr10_-_56444847 Show fit	73.71	ENSRNOT00000056872 ENSRNOT00000092662	Nlgn2 NCBI RGD Ensembl Show fit	neuroligin 2
chr10_+_13854339 Show fit	73.44	ENSRNOT00000004486 ENSRNOT00000043951	Caskin1 NCBI RGD Ensembl Show fit	CASK interacting protein 1

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfdp1_Wt1_Egr2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	322.0	GO:0007269	neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
8.6	248.2	GO:1903831	acetylcholine receptor signaling pathway(GO:0095500) signal transduction involved in cellular response to ammonium ion(GO:1903831) response to acetylcholine(GO:1905144) cellular response to acetylcholine(GO:1905145)
6.2	240.4	GO:0048791	calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
3.9	223.1	GO:0051965	positive regulation of synapse assembly(GO:0051965)
4.8	177.6	GO:0007214	gamma-aminobutyric acid signaling pathway(GO:0007214)
4.1	156.4	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
1.7	147.3	GO:0006334	nucleosome assembly(GO:0006334)
1.4	143.5	GO:0071804	cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
8.4	142.1	GO:0005513	detection of calcium ion(GO:0005513)
4.7	137.6	GO:0045746	negative regulation of Notch signaling pathway(GO:0045746)

Showing 1 to 10 of 1,034 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	699.7	GO:0016021	integral component of membrane(GO:0016021)
3.6	636.1	GO:0008021	synaptic vesicle(GO:0008021)
3.6	536.7	GO:0045211	postsynaptic membrane(GO:0045211)
5.3	438.4	GO:0008076	voltage-gated potassium channel complex(GO:0008076)
9.1	401.9	GO:0048786	presynaptic active zone(GO:0048786)
8.0	357.9	GO:0005891	voltage-gated calcium channel complex(GO:0005891)
3.1	289.9	GO:0098793	presynapse(GO:0098793)
4.7	289.3	GO:0043198	dendritic shaft(GO:0043198)
16.3	261.3	GO:0031045	dense core granule(GO:0031045)
0.4	241.2	GO:0005887	integral component of plasma membrane(GO:0005887)

Showing 1 to 10 of 376 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	614.9	GO:0005509	calcium ion binding(GO:0005509)
3.9	498.3	GO:0044325	ion channel binding(GO:0044325)
1.9	436.1	GO:0008017	microtubule binding(GO:0008017)
5.6	337.9	GO:0005544	calcium-dependent phospholipid binding(GO:0005544)
1.4	283.9	GO:0005096	GTPase activator activity(GO:0005096)
4.5	257.0	GO:0019894	kinesin binding(GO:0019894)
6.9	205.5	GO:0017075	syntaxin-1 binding(GO:0017075)
11.8	164.7	GO:0030550	acetylcholine receptor inhibitor activity(GO:0030550)
6.3	162.7	GO:0016917	GABA-A receptor activity(GO:0004890) GABA receptor activity(GO:0016917)
1.8	161.6	GO:0005200	structural constituent of cytoskeleton(GO:0005200)

Showing 1 to 10 of 607 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.5	373.3	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.6	288.1	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
5.1	212.1	PID REELIN PATHWAY	Reelin signaling pathway
3.7	183.1	PID EPHB FWD PATHWAY	EPHB forward signaling
7.7	161.2	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.5	148.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
2.2	145.9	PID P75 NTR PATHWAY	p75(NTR)-mediated signaling
4.6	129.5	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
2.6	125.8	NABA COLLAGENS	Genes encoding collagen proteins
3.4	119.6	PID TRKR PATHWAY	Neurotrophic factor-mediated Trk receptor signaling

Showing 1 to 10 of 108 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.6	445.4	REACTOME VOLTAGE GATED POTASSIUM CHANNELS	Genes involved in Voltage gated Potassium channels
22.8	342.1	REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Dopamine Neurotransmitter Release Cycle
5.6	219.3	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
8.7	218.1	REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE	Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
11.1	199.9	REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY	Genes involved in Adenylate cyclase inhibitory pathway
5.7	183.6	REACTOME TRAFFICKING OF AMPA RECEPTORS	Genes involved in Trafficking of AMPA receptors
12.2	182.9	REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN	Genes involved in Platelet Adhesion to exposed collagen
10.6	158.8	REACTOME CRMPS IN SEMA3A SIGNALING	Genes involved in CRMPs in Sema3A signaling
2.0	157.6	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
5.0	155.8	REACTOME KINESINS	Genes involved in Kinesins

Showing 1 to 10 of 163 entries

Results for Tfdp1_Wt1_Egr2

Z-value: 2.50

Motif logo

Transcription factors associated with Tfdp1_Wt1_Egr2

Activity-expression correlation:

Activity profile of Tfdp1_Wt1_Egr2 motif

Sorted Z-values of Tfdp1_Wt1_Egr2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfdp1_Wt1_Egr2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: