Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation
Downloads

Results for Tfap4

Z-value: 1.02

Motif logo

Transcription factors associated with Tfap4

Gene Symbol Gene ID Gene Info
ENSRNOG00000005227 transcription factor AP-4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap4rn6_v1_chr10_+_11206226_11206226-0.307.2e-08Click!

Activity profile of Tfap4 motif

Sorted Z-values of Tfap4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_55178289 43.66 ENSRNOT00000059127
crystallin, alpha B
chr6_-_26624092 42.51 ENSRNOT00000008113
tripartite motif-containing 54
chr4_+_144382945 38.87 ENSRNOT00000007601
caveolin 3
chr17_+_32973695 38.59 ENSRNOT00000065674
similar to OTTMUSP00000000621
chr13_-_84331905 35.76 ENSRNOT00000004965
dual specificity phosphatase 27 (putative)
chr18_+_79406381 34.09 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr1_-_89560469 30.82 ENSRNOT00000079091
sodium voltage-gated channel beta subunit 1
chr7_-_83670356 30.56 ENSRNOT00000005584
syntabulin
chr4_-_89151184 30.10 ENSRNOT00000010263
nucleosome assembly protein 1-like 5
chr14_+_37113210 29.91 ENSRNOT00000089094
sarcoglycan, beta
chrX_+_159158194 26.78 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr10_+_92628356 26.59 ENSRNOT00000072480
myosin, light chain 4
chr17_+_12762752 26.33 ENSRNOT00000044842
DIRAS family GTPase 2
chr7_-_141185710 25.79 ENSRNOT00000085033
Fas apoptotic inhibitory molecule 2
chr7_-_139063752 25.72 ENSRNOT00000072309
protein lifeguard 2-like
chr2_+_114386019 25.66 ENSRNOT00000082148

chr8_-_55177818 24.94 ENSRNOT00000013960
heat shock protein family B (small) member 2
chr6_-_105097054 24.76 ENSRNOT00000048606
solute carrier family 8 member A3
chr4_+_199916 24.74 ENSRNOT00000009317
5-hydroxytryptamine receptor 5A
chr3_+_168345152 23.72 ENSRNOT00000017654
docking protein 5
chr6_+_58467254 23.44 ENSRNOT00000065396
ets variant 1
chr16_-_40025401 21.89 ENSRNOT00000066639
ankyrin repeat and SOCS box-containing 5
chr9_+_81821346 21.20 ENSRNOT00000022234
phospholipase C, delta 4
chr2_-_184289126 21.00 ENSRNOT00000081678
F-box and WD repeat domain containing 7
chrX_+_92131209 20.78 ENSRNOT00000004462
poly A binding protein, cytoplasmic 5
chr3_-_61494778 20.64 ENSRNOT00000068018
lunapark, ER junction formation factor
chr10_+_99437436 20.31 ENSRNOT00000006254
potassium voltage-gated channel subfamily J member 2
chr2_-_210943620 19.19 ENSRNOT00000026750
G protein-coupled receptor 61
chr7_+_70807867 19.10 ENSRNOT00000010639
SH3 and cysteine rich domain 3
chr10_-_95934345 18.72 ENSRNOT00000004349
calcium voltage-gated channel auxiliary subunit gamma 1
chr4_-_482645 18.56 ENSRNOT00000062073
ENSRNOT00000071713
canopy FGF signaling regulator 1
chr20_+_20236151 18.43 ENSRNOT00000079630
ankyrin 3
chr18_-_5314511 17.98 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr5_+_151692108 17.55 ENSRNOT00000086144
family with sequence similarity 46, member B
chr8_-_87419564 17.43 ENSRNOT00000015365
filamin A interacting protein 1
chrX_-_134866210 17.28 ENSRNOT00000005331
apelin
chr15_+_19547871 17.26 ENSRNOT00000036235
G protein-coupled receptor 137C
chr17_-_79085076 16.66 ENSRNOT00000057851
family with sequence similarity 171, member A1
chr17_+_1679627 16.59 ENSRNOT00000025801
hyaluronan binding protein 4
chr8_-_43336304 16.24 ENSRNOT00000036054
similar to RIKEN cDNA 5830475I06
chr15_+_110114148 15.65 ENSRNOT00000006264
integrin subunit beta like 1
chr1_+_171793782 15.39 ENSRNOT00000081351
olfactomedin-like 1
chr3_+_150910398 15.32 ENSRNOT00000055310
tumor protein p53 inducible nuclear protein 2
chr5_+_164808323 14.85 ENSRNOT00000011005
natriuretic peptide A
chr15_+_43905099 14.73 ENSRNOT00000016568
early B-cell factor 2
chr16_+_6962722 14.01 ENSRNOT00000023330
musculoskeletal, embryonic nuclear protein 1
chr5_-_58484900 13.58 ENSRNOT00000012386
family with sequence similarity 214, member B
chr3_+_177310753 13.45 ENSRNOT00000031448
myelin transcription factor 1
chr17_+_77167740 13.23 ENSRNOT00000042881
optineurin
chr6_-_102047758 13.13 ENSRNOT00000012101
ATPase H+ transporting V1 subunit D
chr3_-_81304181 12.83 ENSRNOT00000079746
mitogen-activated protein kinase 8 interacting protein 1
chr18_-_14016713 12.80 ENSRNOT00000041125
nucleolar protein 4
chr8_+_130350510 12.58 ENSRNOT00000073376
SS18 like 2
chr4_-_50860756 12.37 ENSRNOT00000068404
calcium dependent secretion activator 2
chr9_-_32019205 12.34 ENSRNOT00000016194
adhesion G protein-coupled receptor B3
chr1_+_201055644 12.16 ENSRNOT00000054937
ENSRNOT00000047161
transforming, acidic coiled-coil containing protein 2
chr1_-_215846911 12.00 ENSRNOT00000089171
insulin-like growth factor 2
chr18_-_56870801 11.78 ENSRNOT00000087188
ENSRNOT00000032189
Rho guanine nucleotide exchange factor 37
chr9_+_111028575 11.49 ENSRNOT00000043451
peptidylglycine alpha-amidating monooxygenase
chr3_-_148932878 11.33 ENSRNOT00000013881
nucleolar protein 4-like
chrX_+_71342775 10.77 ENSRNOT00000004888
integrin subunit beta 1 binding protein 2
chr7_+_73588163 10.66 ENSRNOT00000015707
potassium voltage-gated channel, modifier subfamily S, member 2
chr9_+_111028824 10.66 ENSRNOT00000041418
ENSRNOT00000056457
peptidylglycine alpha-amidating monooxygenase
chr8_+_49676540 10.62 ENSRNOT00000022032
ENSRNOT00000082205
FXYD domain-containing ion transport regulator 6
chr1_+_77994203 10.39 ENSRNOT00000002044
NSF attachment protein alpha
chr10_-_64642292 10.07 ENSRNOT00000084670
active BCR-related
chr3_-_64024205 10.02 ENSRNOT00000037015
coiled-coil domain containing 141
chr7_+_140383397 9.88 ENSRNOT00000090760
coiled-coil domain containing 65
chrX_+_63520991 9.75 ENSRNOT00000071590
apolipoprotein O
chr2_-_98610368 9.54 ENSRNOT00000011641
zinc finger homeobox 4
chr13_+_52662996 9.39 ENSRNOT00000047682
troponin T2, cardiac type
chr8_+_45797315 8.77 ENSRNOT00000059997

chr11_-_24641820 8.75 ENSRNOT00000044081
ENSRNOT00000048854
amyloid beta precursor protein
chr8_-_127900463 8.69 ENSRNOT00000078303
solute carrier family 22 member 13
chr4_+_114876770 8.63 ENSRNOT00000068102
ENSRNOT00000078175
dynactin subunit 1
chr2_+_189423559 8.54 ENSRNOT00000029076
tropomyosin 3
chr4_-_157358262 8.42 ENSRNOT00000021481
G protein subunit beta 3
chr7_+_64672722 8.15 ENSRNOT00000064448
ENSRNOT00000005539
glutamate receptor interacting protein 1
chr2_-_140618405 7.94 ENSRNOT00000017736
SET domain containing (lysine methyltransferase) 7
chr20_+_3556975 7.93 ENSRNOT00000089417
discoidin domain receptor tyrosine kinase 1
chr12_-_25638797 7.67 ENSRNOT00000002033
GATS protein-like 2
chr14_+_42007312 7.37 ENSRNOT00000063985
ATPase phospholipid transporting 8A1
chr1_+_141218095 7.32 ENSRNOT00000051411
similar to 6.8 kDa mitochondrial proteolipid
chr5_-_173318313 7.27 ENSRNOT00000039117
ceramide-1-phosphate transfer protein
chr6_-_21135880 7.14 ENSRNOT00000051239
RAS guanyl releasing protein 3
chr1_-_277768368 7.09 ENSRNOT00000023113
actin filament associated protein 1-like 2
chr7_-_144322240 6.92 ENSRNOT00000089290
calcium-binding and coiled-coil domain-containing protein 1-like
chr2_-_227145185 6.88 ENSRNOT00000083189

chr3_-_72769912 6.86 ENSRNOT00000043742
olfactory receptor 439
chr17_-_55346279 6.83 ENSRNOT00000025037
supervillin
chr1_-_215553451 6.57 ENSRNOT00000027407
cathepsin D
chr15_-_61772516 6.55 ENSRNOT00000015605
ENSRNOT00000093399
WW domain binding protein 4
chr8_-_127912860 6.51 ENSRNOT00000040498
similar to solute carrier family 22 (organic cation transporter), member 13
chr11_-_84047497 6.29 ENSRNOT00000088821
ENSRNOT00000058092
adaptor-related protein complex 2, mu 1 subunit
chr10_-_49007089 6.20 ENSRNOT00000073706
mitogen-activated protein kinase 7
chr7_+_120153184 6.13 ENSRNOT00000013538
galectin 1
chr7_-_44121130 6.11 ENSRNOT00000005706
neurotensin
chr19_-_33424955 6.09 ENSRNOT00000016558
ENSRNOT00000089569
tetratricopeptide repeat domain 29
chr4_-_157358007 5.95 ENSRNOT00000090898
G protein subunit beta 3
chr7_-_145450233 5.56 ENSRNOT00000092974
ENSRNOT00000021523
calcium binding and coiled coil domain 1
chr14_-_37871051 5.49 ENSRNOT00000003087
SLAIN motif family, member 2
chr2_-_53827175 5.49 ENSRNOT00000078158
similar to expressed sequence AW549877
chr12_+_40553741 5.44 ENSRNOT00000057396
rCG21419-like
chr13_-_53224768 5.41 ENSRNOT00000091015
calmodulin regulated spectrin-associated protein family, member 2
chr19_-_41349681 5.40 ENSRNOT00000080694
ENSRNOT00000059147
Hydin, axonemal central pair apparatus protein
chr4_+_181243338 5.39 ENSRNOT00000034051
single-pass membrane protein with coiled-coil domains 2
chr7_+_77678968 5.39 ENSRNOT00000006917
ATPase H+ transporting V1 subunit C1
chr1_+_252906234 5.38 ENSRNOT00000031025
interferon-induced protein with tetratricopeptide repeats 3
chr9_+_17705212 5.38 ENSRNOT00000026728
transmembrane protein 63B
chr1_-_281756159 5.38 ENSRNOT00000013170
prolactin releasing hormone receptor
chr4_-_129544429 5.35 ENSRNOT00000091507
ENSRNOT00000083461
ENSRNOT00000087215
TATA element modulatory factor 1
chr2_-_244370983 5.24 ENSRNOT00000021458
Rap1 GTPase-GDP dissociation stimulator 1
chr6_-_22138286 5.20 ENSRNOT00000007607
Yip1 domain family, member 4
chr9_-_85528860 5.14 ENSRNOT00000063834
ENSRNOT00000088963
WD repeat and FYVE domain containing 1
chr17_-_10208360 5.03 ENSRNOT00000087397
unc-5 netrin receptor A
chr10_+_14828597 4.88 ENSRNOT00000025434
tektin 4
chr10_-_89338739 4.63 ENSRNOT00000073923
prostaglandin E synthase 3 like
chrX_+_62754634 4.56 ENSRNOT00000016669
phosphate cytidylyltransferase 1, choline, beta
chr10_+_55642070 4.37 ENSRNOT00000008507
BLOC-1 related complex subunit 6
chr14_-_114649173 4.27 ENSRNOT00000083528
spectrin, beta, non-erythrocytic 1
chr5_+_172364421 4.24 ENSRNOT00000018769
hes family bHLH transcription factor 5
chr6_+_137164535 4.13 ENSRNOT00000018225
inverted formin, FH2 and WH2 domain containing
chr15_-_4022223 4.10 ENSRNOT00000081997
zinc finger, SWIM-type containing 8
chr10_+_85301875 4.05 ENSRNOT00000080935
suppressor of cytokine signaling 7
chr1_-_214844858 4.03 ENSRNOT00000046344
toll interacting protein
chr8_-_48582353 3.83 ENSRNOT00000011582
PDZ domain containing 3
chr18_+_61490031 3.64 ENSRNOT00000022958
SEC11 homolog C, signal peptidase complex subunit
chr14_-_8548310 3.48 ENSRNOT00000092436
Rho GTPase activating protein 24
chr19_+_24329023 3.48 ENSRNOT00000065558
TBC1 domain family member 9
chr3_-_46153371 3.43 ENSRNOT00000085885
bromodomain adjacent to zinc finger domain, 2B
chr16_-_62294769 3.34 ENSRNOT00000020663
protein phosphatase 2 catalytic subunit beta
chr16_-_32540217 3.27 ENSRNOT00000015130
histone PARylation factor 1
chr11_-_28672956 3.19 ENSRNOT00000002137
hypothetical protein LOC100363136
chr8_-_61836796 3.03 ENSRNOT00000064903
ENSRNOT00000084009
COMM domain containing 4
chr1_-_89509343 2.85 ENSRNOT00000028637
FXYD domain-containing ion transport regulator 3
chr1_-_273758442 2.63 ENSRNOT00000088016
X-prolyl aminopeptidase 1
chr10_-_65780349 2.53 ENSRNOT00000013220
transmembrane protein 199
chr4_-_165810121 2.50 ENSRNOT00000048210
taste receptor, type 2, member 104
chrX_+_23668363 2.43 ENSRNOT00000004758
G protein-coupled receptor 143
chr2_+_243840134 2.29 ENSRNOT00000093355
eukaryotic translation initiation factor 4E
chr3_-_72740519 2.28 ENSRNOT00000040012
olfactory receptor 436
chr1_-_214971929 2.23 ENSRNOT00000027195
MOB kinase activator 2
chr15_-_5894854 2.21 ENSRNOT00000024427
CD99 molecule-like 2
chr8_-_71050853 2.09 ENSRNOT00000073571
ankyrin repeat and death domain containing 1A
chr9_-_120101098 2.03 ENSRNOT00000002917
family with sequence similarity 114, member A1-like 1
chr3_+_111097326 1.97 ENSRNOT00000018717
VPS18 CORVET/HOPS core subunit
chr15_+_5265307 1.92 ENSRNOT00000031807
CD99 antigen-like protein 2
chr4_+_159483131 1.92 ENSRNOT00000089513
similar to DNA segment, Chr 6, Wayne State University 163, expressed
chr5_-_101166651 1.69 ENSRNOT00000078862
Fras1 related extracellular matrix 1
chr8_+_70884491 1.68 ENSRNOT00000072939
ubiquitin associated protein 1-like
chr3_-_5617225 1.68 ENSRNOT00000008327
transmembrane protein 8C
chr19_+_52032886 1.61 ENSRNOT00000019923
malonyl-CoA decarboxylase
chr8_-_55491152 1.60 ENSRNOT00000014965
rCG58364-like
chr14_-_82287706 1.59 ENSRNOT00000080695
fibroblast growth factor receptor 3
chr1_-_273758247 1.51 ENSRNOT00000033148
X-prolyl aminopeptidase 1
chr16_+_32457521 1.37 ENSRNOT00000083579
chloride voltage-gated channel 3
chr2_-_211235440 1.34 ENSRNOT00000033015
ENSRNOT00000091896
seryl-tRNA synthetase
chr12_+_2054680 1.24 ENSRNOT00000001290
mucolipin 1
chr7_+_11838639 1.12 ENSRNOT00000025878
adaptor-related protein complex 3, delta 1 subunit
chr3_-_60460724 1.12 ENSRNOT00000024706
cholinergic receptor nicotinic alpha 1 subunit
chr11_-_36533073 1.11 ENSRNOT00000033486
LCA5L, lebercilin like
chr19_+_14392423 1.08 ENSRNOT00000018880
target of myb1 membrane trafficking protein
chr20_-_11626876 1.03 ENSRNOT00000001635
keratin associated protein 12-1-like
chr10_+_65780494 0.83 ENSRNOT00000013100
DNA polymerase delta interacting protein 2
chr13_-_74740458 0.78 ENSRNOT00000006548
testis expressed 35
chr7_-_125497691 0.74 ENSRNOT00000049445

chr2_+_198683159 0.73 ENSRNOT00000028793
thioredoxin interacting protein
chr8_-_22874637 0.71 ENSRNOT00000064551
ENSRNOT00000090424
dedicator of cytokinesis 6
chr1_+_282188110 0.67 ENSRNOT00000013845
family with sequence similarity 45, member A
chr12_-_16934706 0.50 ENSRNOT00000001720
MAF bZIP transcription factor K
chr8_+_41987849 0.47 ENSRNOT00000073800
olfactory receptor 143-like
chr3_-_72895740 0.43 ENSRNOT00000012568
fatty acid desaturase 2-like 1
chr19_-_37525762 0.43 ENSRNOT00000023606
ATPase H+ transporting V0 subunit D1
chr3_+_16001207 0.43 ENSRNOT00000041987
olfactory receptor 402
chr17_-_29360822 0.40 ENSRNOT00000080031
phenylalanyl-tRNA synthetase 2, mitochondrial
chr10_+_60974225 0.40 ENSRNOT00000042349
olfactory receptor 1511
chr5_-_33892462 0.36 ENSRNOT00000009334
ATPase H+ transporting V0 subunit D2
chrX_-_26376467 0.33 ENSRNOT00000051655
ENSRNOT00000036502
Rho GTPase activating protein 6
chr11_-_17340373 0.22 ENSRNOT00000089762

chr7_+_13039781 0.20 ENSRNOT00000067771
ENSRNOT00000090048
mesoderm induction early response 1, family member 2
chr13_-_73704678 0.17 ENSRNOT00000005280
torsin 1A interacting protein 1
chrX_-_119532965 0.09 ENSRNOT00000073677

chr5_+_156603725 0.06 ENSRNOT00000075852
heterochromatin protein 1, binding protein 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap4

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.


View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.4 34.1 GO:1904685 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
9.7 38.9 GO:0035995 detection of muscle stretch(GO:0035995) positive regulation of caveolin-mediated endocytosis(GO:2001288)
7.0 21.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
6.2 24.9 GO:0007525 somatic muscle development(GO:0007525)
6.2 30.8 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
5.5 22.1 GO:0031179 peptide modification(GO:0031179)
5.5 43.7 GO:0007021 tubulin complex assembly(GO:0007021)
5.0 14.9 GO:1902304 positive regulation of potassium ion export(GO:1902304)
4.6 18.4 GO:0010650 positive regulation of cell communication by electrical coupling(GO:0010650) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
4.3 17.3 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
4.2 4.2 GO:2000974 negative regulation of pro-B cell differentiation(GO:2000974)
4.1 24.7 GO:0007198 adenylate cyclase-inhibiting serotonin receptor signaling pathway(GO:0007198)
4.1 45.1 GO:0014819 regulation of skeletal muscle contraction(GO:0014819)
3.5 14.0 GO:1902730 positive regulation of proteoglycan biosynthetic process(GO:1902730)
3.4 10.1 GO:0043314 negative regulation of neutrophil degranulation(GO:0043314)
3.1 9.4 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
3.0 29.9 GO:0097084 vascular smooth muscle cell development(GO:0097084)
2.9 20.6 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
2.6 10.4 GO:0035494 SNARE complex disassembly(GO:0035494)
2.5 7.4 GO:0061091 regulation of phospholipid translocation(GO:0061091) positive regulation of phospholipid translocation(GO:0061092)
2.1 10.6 GO:0061743 motor learning(GO:0061743)
1.8 5.4 GO:2000845 positive regulation of testosterone secretion(GO:2000845)
1.8 8.8 GO:0048669 collateral sprouting in absence of injury(GO:0048669)
1.7 8.6 GO:0090063 positive regulation of microtubule nucleation(GO:0090063)
1.7 12.0 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
1.7 13.2 GO:0001920 negative regulation of receptor recycling(GO:0001920)
1.6 19.1 GO:0048934 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.5 12.4 GO:1990504 dense core granule exocytosis(GO:1990504)
1.5 16.2 GO:0060923 cardiac muscle cell fate commitment(GO:0060923)
1.5 7.3 GO:0035627 ceramide transport(GO:0035627)
1.4 23.7 GO:0051386 regulation of neurotrophin TRK receptor signaling pathway(GO:0051386)
1.4 25.8 GO:0021681 cerebellar granular layer development(GO:0021681)
1.3 5.4 GO:1904158 axonemal central apparatus assembly(GO:1904158)
1.3 3.8 GO:0030824 negative regulation of cGMP metabolic process(GO:0030824)
1.2 6.2 GO:0071499 cellular response to laminar fluid shear stress(GO:0071499)
1.2 6.1 GO:0002317 plasma cell differentiation(GO:0002317)
1.2 13.5 GO:0060539 diaphragm development(GO:0060539)
1.2 6.1 GO:0097332 response to antipsychotic drug(GO:0097332)
1.2 12.8 GO:0007258 JUN phosphorylation(GO:0007258)
1.1 14.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
1.1 12.2 GO:0030953 astral microtubule organization(GO:0030953)
1.1 3.3 GO:0018312 peptidyl-serine ADP-ribosylation(GO:0018312)
1.1 15.2 GO:0043252 sodium-independent organic anion transport(GO:0043252)
1.1 42.5 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.0 4.9 GO:0080154 regulation of fertilization(GO:0080154)
0.9 6.3 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
0.8 5.0 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.8 20.0 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.8 7.9 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.8 10.7 GO:1902259 regulation of delayed rectifier potassium channel activity(GO:1902259)
0.7 5.1 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.7 7.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.7 18.7 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
0.7 26.8 GO:1901016 regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.7 5.2 GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration(GO:0032471)
0.6 9.7 GO:0042407 cristae formation(GO:0042407)
0.6 2.4 GO:1903056 regulation of melanosome organization(GO:1903056)
0.6 20.2 GO:0003009 skeletal muscle contraction(GO:0003009)
0.6 4.6 GO:1904116 response to vasopressin(GO:1904116)
0.6 1.1 GO:0070142 synaptic vesicle budding(GO:0070142)
0.6 1.7 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
0.5 1.6 GO:0034034 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) fatty-acyl-CoA catabolic process(GO:0036115)
0.5 4.1 GO:0010815 bradykinin catabolic process(GO:0010815)
0.5 21.2 GO:0007340 acrosome reaction(GO:0007340)
0.5 4.1 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.4 4.3 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
0.4 5.5 GO:0007020 microtubule nucleation(GO:0007020)
0.4 13.5 GO:2000649 regulation of sodium ion transmembrane transporter activity(GO:2000649)
0.4 10.0 GO:0051642 centrosome localization(GO:0051642)
0.3 3.5 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.3 1.4 GO:0097401 synaptic vesicle lumen acidification(GO:0097401)
0.3 3.6 GO:0006465 signal peptide processing(GO:0006465)
0.3 13.1 GO:0061512 protein localization to cilium(GO:0061512)
0.3 1.6 GO:0061144 alveolar secondary septum development(GO:0061144)
0.3 6.6 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.3 22.7 GO:0061178 regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061178)
0.3 2.0 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.3 21.9 GO:0000045 autophagosome assembly(GO:0000045)
0.3 28.0 GO:0006334 nucleosome assembly(GO:0006334)
0.2 4.0 GO:0033235 positive regulation of protein sumoylation(GO:0033235) protein localization to endosome(GO:0036010)
0.2 18.0 GO:0048663 neuron fate commitment(GO:0048663)
0.2 6.2 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.2 7.1 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.2 16.6 GO:0071260 cellular response to mechanical stimulus(GO:0071260)
0.2 4.1 GO:0090140 regulation of mitochondrial fission(GO:0090140)
0.2 5.4 GO:0035458 cellular response to interferon-beta(GO:0035458)
0.1 26.3 GO:0043406 positive regulation of MAP kinase activity(GO:0043406)
0.1 1.7 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.1 1.7 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 6.3 GO:0032418 lysosome localization(GO:0032418)
0.1 0.4 GO:0006432 phenylalanyl-tRNA aminoacylation(GO:0006432)
0.1 3.3 GO:0051058 negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058)
0.1 1.2 GO:0097352 autophagosome maturation(GO:0097352)
0.0 0.8 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.0 8.5 GO:0006936 muscle contraction(GO:0006936)
0.0 1.6 GO:0048741 skeletal muscle fiber development(GO:0048741)
0.0 0.7 GO:0002347 response to tumor cell(GO:0002347)
0.0 8.2 GO:0016358 dendrite development(GO:0016358)
0.0 0.3 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of adherens junction organization(GO:1903392)
0.0 1.3 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.0 2.3 GO:0006413 translational initiation(GO:0006413)
0.0 4.5 GO:0006470 protein dephosphorylation(GO:0006470)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 53.0 GO:0097512 cardiac myofibril(GO:0097512)
5.7 34.1 GO:0033269 internode region of axon(GO:0033269)
5.0 29.9 GO:0016012 sarcoglycan complex(GO:0016012)
4.3 12.8 GO:0044302 dentate gyrus mossy fiber(GO:0044302)
4.2 21.0 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
3.1 30.6 GO:0097433 dense body(GO:0097433)
3.0 38.9 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
2.2 8.8 GO:1990812 growth cone lamellipodium(GO:1990761) growth cone filopodium(GO:1990812)
2.0 49.3 GO:0033268 node of Ranvier(GO:0033268)
1.7 10.4 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.4 9.7 GO:0061617 MICOS complex(GO:0061617)
1.2 8.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
1.1 8.6 GO:0005869 dynactin complex(GO:0005869)
1.1 5.4 GO:1990716 axonemal central apparatus(GO:1990716)
1.1 5.4 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.8 12.3 GO:0043083 synaptic cleft(GO:0043083)
0.8 5.4 GO:0036449 microtubule minus-end(GO:0036449)
0.6 6.8 GO:0043034 costamere(GO:0043034)
0.6 3.6 GO:0005787 signal peptidase complex(GO:0005787)
0.6 30.9 GO:0031672 A band(GO:0031672)
0.6 13.9 GO:0033176 proton-transporting V-type ATPase complex(GO:0033176)
0.5 14.9 GO:0042629 mast cell granule(GO:0042629)
0.5 20.3 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.4 7.1 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.4 44.1 GO:0030018 Z disc(GO:0030018)
0.4 6.3 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.4 18.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.4 24.8 GO:0016528 sarcoplasm(GO:0016528)
0.4 16.6 GO:0030017 sarcomere(GO:0030017)
0.4 1.1 GO:0098830 presynaptic endosome(GO:0098830)
0.3 2.4 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.3 2.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 7.3 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 22.1 GO:0030667 secretory granule membrane(GO:0030667)
0.3 7.3 GO:0005753 mitochondrial proton-transporting ATP synthase complex(GO:0005753)
0.2 24.7 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 4.9 GO:0097225 sperm midpiece(GO:0097225)
0.2 2.0 GO:0033263 CORVET complex(GO:0033263)
0.2 21.5 GO:0016605 PML body(GO:0016605)
0.2 44.6 GO:0045211 postsynaptic membrane(GO:0045211)
0.2 1.7 GO:0000813 ESCRT I complex(GO:0000813)
0.2 5.5 GO:1990752 microtubule plus-end(GO:0035371) microtubule end(GO:1990752)
0.1 5.0 GO:0032809 neuronal cell body membrane(GO:0032809)
0.1 10.7 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 3.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 2.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.1 1.4 GO:0042581 specific granule(GO:0042581)
0.1 6.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 1.6 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 13.2 GO:0055037 recycling endosome(GO:0055037)
0.0 7.9 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 7.5 GO:0031965 nuclear membrane(GO:0031965)
0.0 7.1 GO:0005925 focal adhesion(GO:0005925)
0.0 0.8 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 1.4 GO:0044306 neuron projection terminus(GO:0044306)
0.0 4.8 GO:0005813 centrosome(GO:0005813)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 30.8 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
5.5 22.1 GO:0016842 amidine-lyase activity(GO:0016842)
4.9 38.9 GO:0071253 connexin binding(GO:0071253)
4.2 21.0 GO:0050816 phosphothreonine binding(GO:0050816)
3.5 24.8 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
3.5 10.4 GO:0005483 soluble NSF attachment protein activity(GO:0005483)
3.1 68.6 GO:0005212 structural constituent of eye lens(GO:0005212)
2.8 34.1 GO:0019911 structural constituent of myelin sheath(GO:0019911)
2.6 13.2 GO:0001155 TFIIIA-class transcription factor binding(GO:0001155)
2.3 9.4 GO:0030172 troponin C binding(GO:0030172)
2.2 8.8 GO:0051425 PTB domain binding(GO:0051425)
1.8 12.8 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
1.8 7.3 GO:0017089 glycolipid transporter activity(GO:0017089)
1.8 24.7 GO:0051378 serotonin binding(GO:0051378)
1.6 20.3 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
1.2 1.2 GO:0072345 NAADP-sensitive calcium-release channel activity(GO:0072345)
1.1 7.9 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
1.1 15.2 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
1.0 6.1 GO:0048030 disaccharide binding(GO:0048030)
1.0 5.0 GO:0005042 netrin receptor activity(GO:0005042)
0.9 20.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.9 4.6 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.9 30.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.8 32.1 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.7 12.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.6 5.8 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.6 30.9 GO:0030507 spectrin binding(GO:0030507)
0.6 31.7 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6 5.6 GO:0070016 armadillo repeat domain binding(GO:0070016)
0.5 8.2 GO:0030159 receptor signaling complex scaffold activity(GO:0030159)
0.5 3.8 GO:0030249 guanylate cyclase regulator activity(GO:0030249)
0.5 1.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.4 5.4 GO:0004983 neuropeptide Y receptor activity(GO:0004983)
0.4 7.1 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.4 18.7 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.3 6.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.3 10.1 GO:0003785 actin monomer binding(GO:0003785)
0.3 7.4 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.3 13.5 GO:0017080 sodium channel regulator activity(GO:0017080)
0.3 6.3 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.3 8.6 GO:0070840 dynein complex binding(GO:0070840)
0.3 8.8 GO:0005158 insulin receptor binding(GO:0005158)
0.3 4.0 GO:0035325 Toll-like receptor binding(GO:0035325)
0.3 6.6 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.2 2.3 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.2 6.2 GO:0004707 MAP kinase activity(GO:0004707)
0.2 26.8 GO:0044325 ion channel binding(GO:0044325)
0.2 1.6 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 8.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 4.1 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 7.9 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.1 2.4 GO:0035240 dopamine binding(GO:0035240)
0.1 0.5 GO:0071535 RING-like zinc finger domain binding(GO:0071535)
0.1 13.8 GO:0043130 ubiquitin binding(GO:0043130)
0.1 13.1 GO:0043492 ATPase activity, coupled to transmembrane movement of substances(GO:0042626) ATPase activity, coupled to movement of substances(GO:0043492)
0.1 25.9 GO:0003924 GTPase activity(GO:0003924)
0.1 9.2 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.1 4.3 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.4 GO:0004826 phenylalanine-tRNA ligase activity(GO:0004826)
0.1 1.1 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
0.1 3.3 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.1 0.3 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 12.5 GO:0008017 microtubule binding(GO:0008017)
0.0 1.6 GO:0016831 carboxy-lyase activity(GO:0016831)
0.0 1.1 GO:0030276 clathrin binding(GO:0030276)
0.0 1.3 GO:0016875 aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876)
0.0 2.0 GO:0019905 syntaxin binding(GO:0019905)
0.0 6.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 6.4 GO:0005549 odorant binding(GO:0005549)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 32.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.9 23.4 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.6 25.8 PID FAS PATHWAY FAS (CD95) signaling pathway
0.6 23.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.6 12.8 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.6 28.1 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.5 14.4 PID CONE PATHWAY Visual signal transduction: Cones
0.3 6.2 ST GA12 PATHWAY G alpha 12 Pathway
0.2 6.1 PID RAS PATHWAY Regulation of Ras family activation
0.2 8.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 12.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.2 4.5 PID ARF 3PATHWAY Arf1 pathway
0.2 8.8 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 8.1 PID AR PATHWAY Coregulation of Androgen receptor activity
0.1 7.6 PID TGFBR PATHWAY TGF-beta receptor signaling
0.1 6.7 PID P53 REGULATION PATHWAY p53 pathway
0.1 2.3 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.1 5.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 4.2 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.1 PID ERBB2 ERBB3 PATHWAY ErbB2/ErbB3 signaling events
0.0 6.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 24.7 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
1.5 53.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.2 34.7 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
1.1 44.5 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
1.0 24.8 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.8 9.5 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.7 19.3 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.7 6.3 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.7 9.5 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.7 21.0 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 12.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.5 14.9 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.4 5.0 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 1.2 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 10.7 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.2 6.6 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.2 7.4 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 8.6 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.2 4.6 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 2.3 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 1.6 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.1 REACTOME PRESYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Presynaptic nicotinic acetylcholine receptors
0.1 5.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 6.7 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 11.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.1 5.9 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.0 1.3 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 3.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.9 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.4 REACTOME TRNA AMINOACYLATION Genes involved in tRNA Aminoacylation