ISMARA results: Tfap4

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfap4

Z-value: 1.02

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Transcription factors associated with Tfap4

Gene Symbol	Gene ID	Gene Info
Tfap4 NCBI RGD Ensembl	ENSRNOG00000005227	transcription factor AP-4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfap4	rn6_v1_chr10_+_11206226_11206226	-0.30	7.2e-08	Click!

Activity profile of Tfap4 motif

Sorted Z-values of Tfap4 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_+_55178289 Show fit	43.66	ENSRNOT00000059127	Cryab NCBI RGD Ensembl Show fit	crystallin, alpha B
chr6_-_26624092 Show fit	42.51	ENSRNOT00000008113	Trim54 NCBI RGD Ensembl Show fit	tripartite motif-containing 54
chr4_+_144382945 Show fit	38.87	ENSRNOT00000007601	Cav3 NCBI RGD Ensembl Show fit	caveolin 3
chr17_+_32973695 Show fit	38.59	ENSRNOT00000065674	RGD1565323 NCBI RGD Ensembl Show fit	similar to OTTMUSP00000000621
chr13_-_84331905 Show fit	35.76	ENSRNOT00000004965	Dusp27 NCBI RGD Ensembl Show fit	dual specificity phosphatase 27 (putative)
chr18_+_79406381 Show fit	34.09	ENSRNOT00000022303 ENSRNOT00000058295 ENSRNOT00000058296 ENSRNOT00000022280	Mbp NCBI RGD Ensembl Show fit	myelin basic protein
chr1_-_89560469 Show fit	30.82	ENSRNOT00000079091	Scn1b NCBI RGD Ensembl Show fit	sodium voltage-gated channel beta subunit 1
chr7_-_83670356 Show fit	30.56	ENSRNOT00000005584	Sybu NCBI RGD Ensembl Show fit	syntabulin
chr4_-_89151184 Show fit	30.10	ENSRNOT00000010263	Nap1l5 NCBI RGD Ensembl Show fit	nucleosome assembly protein 1-like 5
chr14_+_37113210 Show fit	29.91	ENSRNOT00000089094	Sgcb NCBI RGD Ensembl Show fit	sarcoglycan, beta

Showing 1 to 10 of 183 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.1	45.1	GO:0014819	regulation of skeletal muscle contraction(GO:0014819)
5.5	43.7	GO:0007021	tubulin complex assembly(GO:0007021)
1.1	42.5	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
9.7	38.9	GO:0035995	detection of muscle stretch(GO:0035995) positive regulation of caveolin-mediated endocytosis(GO:2001288)
11.4	34.1	GO:1904685	regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
6.2	30.8	GO:0021966	corticospinal neuron axon guidance(GO:0021966)
3.0	29.9	GO:0097084	vascular smooth muscle cell development(GO:0097084)
0.3	28.0	GO:0006334	nucleosome assembly(GO:0006334)
0.7	26.8	GO:1901016	regulation of potassium ion transmembrane transporter activity(GO:1901016)
0.1	26.3	GO:0043406	positive regulation of MAP kinase activity(GO:0043406)

Showing 1 to 10 of 102 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
5.9	53.0	GO:0097512	cardiac myofibril(GO:0097512)
2.0	49.3	GO:0033268	node of Ranvier(GO:0033268)
0.2	44.6	GO:0045211	postsynaptic membrane(GO:0045211)
0.4	44.1	GO:0030018	Z disc(GO:0030018)
3.0	38.9	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
5.7	34.1	GO:0033269	internode region of axon(GO:0033269)
0.6	30.9	GO:0031672	A band(GO:0031672)
3.1	30.6	GO:0097433	dense body(GO:0097433)
5.0	29.9	GO:0016012	sarcoglycan complex(GO:0016012)
0.4	24.8	GO:0016528	sarcoplasm(GO:0016528)

Showing 1 to 10 of 56 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	68.6	GO:0005212	structural constituent of eye lens(GO:0005212)
4.9	38.9	GO:0071253	connexin binding(GO:0071253)
2.8	34.1	GO:0019911	structural constituent of myelin sheath(GO:0019911)
0.8	32.1	GO:0071855	neuropeptide receptor binding(GO:0071855)
0.6	31.7	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.6	30.9	GO:0030507	spectrin binding(GO:0030507)
6.2	30.8	GO:0086062	voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
0.9	30.6	GO:0017075	syntaxin-1 binding(GO:0017075)
0.2	26.8	GO:0044325	ion channel binding(GO:0044325)
0.1	25.9	GO:0003924	GTPase activity(GO:0003924)

Showing 1 to 10 of 69 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	32.3	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.6	28.1	ST T CELL SIGNAL TRANSDUCTION	T Cell Signal Transduction
0.6	25.8	PID FAS PATHWAY	FAS (CD95) signaling pathway
0.6	23.7	PID RET PATHWAY	Signaling events regulated by Ret tyrosine kinase
0.9	23.4	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
0.5	14.4	PID CONE PATHWAY	Visual signal transduction: Cones
0.6	12.8	ST GRANULE CELL SURVIVAL PATHWAY	Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.2	12.0	PID AJDISS 2PATHWAY	Posttranslational regulation of adherens junction stability and dissassembly
0.2	8.8	PID CASPASE PATHWAY	Caspase cascade in apoptosis
0.2	8.6	PID NCADHERIN PATHWAY	N-cadherin signaling events

Showing 1 to 10 of 21 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.5	53.5	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
1.1	44.5	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.2	34.7	REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS	Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
1.0	24.8	REACTOME PLATELET CALCIUM HOMEOSTASIS	Genes involved in Platelet calcium homeostasis
1.8	24.7	REACTOME SEROTONIN RECEPTORS	Genes involved in Serotonin receptors
0.7	21.0	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.7	19.3	REACTOME INSULIN RECEPTOR RECYCLING	Genes involved in Insulin receptor recycling
0.5	14.9	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6	12.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1	11.5	REACTOME PEPTIDE LIGAND BINDING RECEPTORS	Genes involved in Peptide ligand-binding receptors

Showing 1 to 10 of 31 entries

Results for Tfap4

Z-value: 1.02

Motif logo

Transcription factors associated with Tfap4

Activity-expression correlation:

Activity profile of Tfap4 motif

Sorted Z-values of Tfap4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: