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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Tfap2c
Z-value: 1.13
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Transcription factors associated with Tfap2c
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tfap2c | rn6_v1_chr3_+_170550314_170550314 | 0.00 | 9.6e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tfap2c
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 17.2 | 51.6 | GO:1990926 | short-term synaptic potentiation(GO:1990926) |
| 7.1 | 42.9 | GO:0010045 | response to nickel cation(GO:0010045) |
| 14.1 | 42.4 | GO:0048378 | ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) |
| 2.5 | 36.9 | GO:0061469 | regulation of type B pancreatic cell proliferation(GO:0061469) |
| 7.4 | 29.7 | GO:0006546 | glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464) |
| 2.1 | 27.1 | GO:0042178 | xenobiotic catabolic process(GO:0042178) |
| 1.8 | 26.7 | GO:0051639 | actin filament network formation(GO:0051639) |
| 3.6 | 25.2 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
| 2.6 | 23.2 | GO:0090336 | positive regulation of brown fat cell differentiation(GO:0090336) |
| 0.3 | 21.6 | GO:0015909 | long-chain fatty acid transport(GO:0015909) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 53.5 | GO:0016021 | integral component of membrane(GO:0016021) |
| 4.7 | 51.6 | GO:0032009 | early phagosome(GO:0032009) |
| 0.3 | 50.4 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 1.1 | 47.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.1 | 34.7 | GO:0043235 | receptor complex(GO:0043235) |
| 1.1 | 26.7 | GO:0005865 | striated muscle thin filament(GO:0005865) |
| 1.3 | 25.2 | GO:0043196 | varicosity(GO:0043196) |
| 0.1 | 25.1 | GO:0043204 | perikaryon(GO:0043204) |
| 0.3 | 23.2 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 21.9 | GO:0005887 | integral component of plasma membrane(GO:0005887) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 47.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 8.6 | 42.9 | GO:0008332 | low voltage-gated calcium channel activity(GO:0008332) |
| 5.3 | 42.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 1.6 | 30.8 | GO:0016594 | glycine binding(GO:0016594) |
| 0.5 | 30.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 29.8 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 5.4 | 27.1 | GO:0070404 | NADH binding(GO:0070404) |
| 4.2 | 25.2 | GO:0031749 | D2 dopamine receptor binding(GO:0031749) |
| 0.2 | 22.3 | GO:0005179 | hormone activity(GO:0005179) |
| 5.4 | 21.6 | GO:0016416 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 44.1 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 30.7 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 1.0 | 25.2 | PID IL8 CXCR1 PATHWAY | IL8- and CXCR1-mediated signaling events |
| 0.4 | 21.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.3 | 20.0 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.3 | 17.4 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.8 | 15.9 | PID LPA4 PATHWAY | LPA4-mediated signaling events |
| 0.4 | 15.5 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
| 0.9 | 11.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.6 | 10.9 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.3 | 43.3 | REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 | Genes involved in Signaling by activated point mutants of FGFR1 |
| 0.8 | 34.5 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 0.2 | 25.3 | REACTOME POTASSIUM CHANNELS | Genes involved in Potassium Channels |
| 2.8 | 25.2 | REACTOME GAP JUNCTION DEGRADATION | Genes involved in Gap junction degradation |
| 1.4 | 21.6 | REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE | Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle |
| 2.2 | 20.0 | REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK | Genes involved in Regulation of Rheb GTPase activity by AMPK |
| 0.4 | 19.5 | REACTOME MITOCHONDRIAL PROTEIN IMPORT | Genes involved in Mitochondrial Protein Import |
| 0.8 | 19.2 | REACTOME PLATELET CALCIUM HOMEOSTASIS | Genes involved in Platelet calcium homeostasis |
| 0.7 | 17.9 | REACTOME SYNTHESIS OF PC | Genes involved in Synthesis of PC |
| 0.2 | 17.4 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |