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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfap2c

Z-value: 1.13

Motif logo

Transcription factors associated with Tfap2c

Gene Symbol Gene ID Gene Info
ENSRNOG00000005246 transcription factor AP-2 gamma

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tfap2crn6_v1_chr3_+_170550314_1705503140.009.6e-01Click!

Activity profile of Tfap2c motif

Sorted Z-values of Tfap2c motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_226435979 51.62 ENSRNOT00000048704
ENSRNOT00000036232
ENSRNOT00000035576
ENSRNOT00000036180
ENSRNOT00000036168
ENSRNOT00000047964
ENSRNOT00000036283
ENSRNOT00000007429
synaptotagmin 7
chrX_+_39711201 29.82 ENSRNOT00000080512
ENSRNOT00000009802
connector enhancer of kinase suppressor of Ras 2
chr2_+_260884337 27.09 ENSRNOT00000032808
crystallin zeta
chr18_+_17091310 26.75 ENSRNOT00000093285
formin homology 2 domain containing 3
chr4_-_117268178 25.58 ENSRNOT00000043201
ENSRNOT00000084049
F-box protein 41
chr5_+_151692108 25.21 ENSRNOT00000086144
family with sequence similarity 46, member B
chr3_-_11382004 25.20 ENSRNOT00000047921
ENSRNOT00000064039
dynamin 1
chr9_-_82461903 25.08 ENSRNOT00000026654
protein tyrosine phosphatase, receptor type, N
chr10_-_82197848 23.31 ENSRNOT00000081307
calcium voltage-gated channel subunit alpha1 G
chr5_+_147323240 23.23 ENSRNOT00000047152
fibronectin type III domain containing 5
chr16_-_71319449 22.55 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr7_-_130405347 21.62 ENSRNOT00000013985
carnitine palmitoyltransferase 1B
chr4_+_132137793 20.69 ENSRNOT00000014455
G protein-coupled receptor 27
chr5_-_124642569 19.96 ENSRNOT00000010680
protein kinase AMP-activated catalytic subunit alpha 2
chr18_+_83471342 19.94 ENSRNOT00000019384
neuropilin and tolloid like 1
chr16_-_71319052 19.83 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr10_-_82197520 19.57 ENSRNOT00000092024
calcium voltage-gated channel subunit alpha1 G
chr14_-_78707861 19.45 ENSRNOT00000091927
protein phosphatase 2, regulatory subunit B, gamma
chr6_-_105097054 19.21 ENSRNOT00000048606
solute carrier family 8 member A3
chr10_-_51669297 19.01 ENSRNOT00000071595
Rho GTPase activating protein 44
chr13_-_102790639 18.52 ENSRNOT00000003177
similar to hypothetical protein FLJ14146
chr19_-_15840990 18.45 ENSRNOT00000015583
iroquois homeobox 3
chr1_-_53038229 18.12 ENSRNOT00000017282
mitochondrial pyruvate carrier 1
chr15_-_48670257 17.87 ENSRNOT00000071464
frizzled class receptor 3
chr7_-_29070928 17.86 ENSRNOT00000080939
choline phosphotransferase 1
chr7_+_117409576 16.89 ENSRNOT00000017067
cytochrome c-1
chr11_+_82734613 16.88 ENSRNOT00000074826
transmembrane protein 41a
chr9_+_90857308 16.82 ENSRNOT00000073993
collagen alpha-3(IV) chain-like
chr3_+_111597102 16.22 ENSRNOT00000081462
TYRO3 protein tyrosine kinase
chr8_+_63600663 16.19 ENSRNOT00000012644
hyperpolarization activated cyclic nucleotide-gated potassium channel 4
chr1_-_248376750 16.18 ENSRNOT00000089073
glycine decarboxylase
chr11_-_68842320 15.89 ENSRNOT00000049180
adenylate cyclase 5
chr6_+_9483594 15.32 ENSRNOT00000089272

chrX_-_134866210 15.22 ENSRNOT00000005331
apelin
chr10_+_57322331 14.79 ENSRNOT00000041493
kinesin family member 1C
chr18_-_57245666 14.70 ENSRNOT00000080365
actin binding LIM protein family, member 3
chr5_-_65073012 14.66 ENSRNOT00000007957
glutamate ionotropic receptor NMDA type subunit 3A
chr10_-_89916400 14.60 ENSRNOT00000055194
dual specificity phosphatase 3
chr6_+_137063611 14.23 ENSRNOT00000017504
hypothetical protein LOC691485
chrX_-_104493714 14.14 ENSRNOT00000064458
ENSRNOT00000080386
protocadherin 19
chr5_+_79055521 14.00 ENSRNOT00000010333
collagen type XXVII alpha 1 chain
chr17_+_36334147 13.78 ENSRNOT00000050261
E2F transcription factor 3
chr8_+_117068582 13.57 ENSRNOT00000073559
aminomethyltransferase
chr3_-_1924827 13.20 ENSRNOT00000006162
calcium voltage-gated channel subunit alpha1 B
chr14_+_80248140 13.06 ENSRNOT00000010852
HtrA serine peptidase 3
chr10_+_70262361 12.87 ENSRNOT00000064625
ENSRNOT00000076973
unc-45 myosin chaperone B
chr5_-_74029238 12.62 ENSRNOT00000031432
ferric-chelate reductase 1-like
chr8_-_107681512 12.57 ENSRNOT00000077963
muscle RAS oncogene homolog
chr6_-_132183434 12.25 ENSRNOT00000079807

chr10_-_15311189 12.21 ENSRNOT00000027371
proline rich 35
chr1_-_71290337 12.13 ENSRNOT00000063956
zinc finger protein 667
chr3_+_172385672 11.94 ENSRNOT00000090989
GNAS complex locus
chrX_+_15114892 11.77 ENSRNOT00000078168
WD repeat domain 13
chr1_+_220362064 11.58 ENSRNOT00000074361
endosialin
chr1_-_214181686 11.28 ENSRNOT00000022363
ENSRNOT00000079464
Harvey rat sarcoma virus oncogene
chr1_+_220446425 11.01 ENSRNOT00000027339
endosialin-like
chr10_+_65767930 10.93 ENSRNOT00000039954
vitronectin
chr5_-_164747083 10.77 ENSRNOT00000010433
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1
chr9_+_101005082 10.69 ENSRNOT00000082949
neuraminidase 4
chr14_+_39661968 10.66 ENSRNOT00000064779
gamma-aminobutyric acid type A receptor alpha2 subunit
chr1_-_73753128 10.35 ENSRNOT00000068459
tweety family member 1
chr16_-_20686317 10.34 ENSRNOT00000060097
cytokine receptor-like factor 1
chr1_-_64030175 10.28 ENSRNOT00000089950
tRNA splicing endonuclease subunit 34-like 1
chr5_+_169519212 10.27 ENSRNOT00000024732
chromodomain helicase DNA binding protein 5
chr1_-_84491466 9.90 ENSRNOT00000034609
mitogen activated protein kinase kinase kinase 10
chr5_-_139227196 9.87 ENSRNOT00000050941
forkhead box O6
chr9_+_47386626 9.79 ENSRNOT00000021270
solute carrier family 9 member A2
chr19_+_2393059 9.70 ENSRNOT00000018535
cadherin 11
chr1_+_220353356 9.56 ENSRNOT00000080189
CD248 molecule
chr2_+_207923775 9.55 ENSRNOT00000019997
ENSRNOT00000051835
potassium voltage-gated channel subfamily D member 3
chr10_-_68517564 9.36 ENSRNOT00000086961
acid sensing ion channel subunit 2
chr1_+_30681681 9.16 ENSRNOT00000015395
R-spondin 3
chr9_+_17340341 9.11 ENSRNOT00000026637
ENSRNOT00000026559
ENSRNOT00000042790
ENSRNOT00000044163
ENSRNOT00000083811
vascular endothelial growth factor A
chr5_+_18901039 9.00 ENSRNOT00000012066
family with sequence similarity 110, member B
chr9_-_82673898 8.98 ENSRNOT00000027165
chondroitin polymerizing factor
chr7_+_116745061 8.68 ENSRNOT00000076174
rhophilin, Rho GTPase binding protein 1
chr20_+_5815837 8.58 ENSRNOT00000036999
lipoma HMGIC fusion partner-like 5
chr15_+_61731735 8.43 ENSRNOT00000015517
kelch repeat and BTB domain containing 6
chr19_-_53688597 8.38 ENSRNOT00000074448
zinc finger CCHC-type containing 14
chr14_+_83724933 8.31 ENSRNOT00000029848
phospholipase A2, group III
chr10_+_56824505 8.28 ENSRNOT00000067128
solute carrier family 16, member 11
chr1_-_18058055 8.26 ENSRNOT00000020988
protein tyrosine phosphatase, receptor type, K
chr9_+_16737642 7.94 ENSRNOT00000061430
serum response factor
chr3_+_123434409 7.83 ENSRNOT00000028847
attractin
chr8_-_68966108 7.75 ENSRNOT00000012155
SMAD family member 6
chr4_-_82203154 7.51 ENSRNOT00000086210
homeobox protein Hox-A10-like
chr19_+_37476095 7.51 ENSRNOT00000092794
ENSRNOT00000023130
hydroxysteroid 11-beta dehydrogenase 2
chr7_-_117259791 7.49 ENSRNOT00000086550
plectin
chr3_+_171832500 7.35 ENSRNOT00000007554
VAMP associated protein B and C
chr4_-_82289672 7.09 ENSRNOT00000036394
homeobox A10
chr7_-_117288018 7.04 ENSRNOT00000091285
plectin
chr4_-_157829241 7.00 ENSRNOT00000026184
lymphotoxin beta receptor
chr14_-_84978255 6.93 ENSRNOT00000078179
calcium binding protein 7
chr8_-_23063041 6.90 ENSRNOT00000018416
ELAV like RNA binding protein 3
chr8_+_116324040 6.89 ENSRNOT00000081353
hyaluronoglucosaminidase 2
chr1_-_99303048 6.83 ENSRNOT00000025631
similar to Kallikrein-1 precursor (Tissue kallikrein) (Kidney/pancreas/salivary gland kallikrein)
chr3_-_11410732 6.81 ENSRNOT00000034930
similar to Hypothetical UPF0184 protein C9orf16 homolog
chr19_-_57699113 6.73 ENSRNOT00000026767
egl-9 family hypoxia-inducible factor 1
chr10_-_109224370 6.57 ENSRNOT00000005839
apoptosis-associated tyrosine kinase
chr9_+_82120059 6.51 ENSRNOT00000057368
cyclin-dependent kinase 5 regulatory subunit 2
chrX_-_32355296 6.47 ENSRNOT00000081652
ENSRNOT00000065075
adaptor-related protein complex 1, sigma 2 subunit
chr3_+_160908769 6.46 ENSRNOT00000030054
Sys1 golgi trafficking protein
chr6_-_99783047 6.41 ENSRNOT00000009028
spectrin, beta, erythrocytic
chr1_+_170383682 6.30 ENSRNOT00000024224
sphingomyelin phosphodiesterase 1
chr5_+_150080072 6.24 ENSRNOT00000047917
transmembrane protein 200B
chr15_-_3410423 6.09 ENSRNOT00000080274
adenosine kinase
chr7_-_49250953 6.08 ENSRNOT00000066975
ENSRNOT00000082141
acyl-CoA synthetase short-chain family member 3
chr11_+_28692708 6.04 ENSRNOT00000002135
keratin associated protein 13-1
chr1_+_100299626 6.00 ENSRNOT00000092327
ENSRNOT00000044257
SH3 and multiple ankyrin repeat domains 1
chr5_+_123905166 5.95 ENSRNOT00000082021
DAB1, reelin adaptor protein
chr8_-_63350269 5.95 ENSRNOT00000042681
Cd276 molecule
chr2_-_260884449 5.92 ENSRNOT00000032874
tRNA-yW synthesizing protein 3 homolog
chr5_+_143500441 5.91 ENSRNOT00000045513
glutamate ionotropic receptor kainate type subunit 3
chr5_+_162031722 5.89 ENSRNOT00000020483
leucine rich repeat containing 38
chr6_-_86822094 5.85 ENSRNOT00000006531
FK506 binding protein 3
chr9_+_16862248 5.78 ENSRNOT00000080104
ENSRNOT00000024824
tau tubulin kinase 1
chr8_-_43854765 5.47 ENSRNOT00000081506
olfactory receptor 1335
chr5_-_64789318 5.31 ENSRNOT00000078957
mitochondrial ribosomal protein L50
chr3_-_105470475 5.29 ENSRNOT00000011078
gap junction protein, delta 2
chr10_+_65780494 5.18 ENSRNOT00000013100
DNA polymerase delta interacting protein 2
chr10_+_13836128 4.96 ENSRNOT00000012720
phosphoglycolate phosphatase
chr1_+_142679345 4.92 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr5_-_160619650 4.68 ENSRNOT00000089981
transmembrane protein 51
chr1_+_220400855 4.57 ENSRNOT00000027178
solute carrier family 29 member 2
chr1_-_218100272 4.53 ENSRNOT00000028411
ENSRNOT00000088588
cyclin D1
chr12_-_30304036 4.52 ENSRNOT00000001218
nuclear protein 2, transcriptional regulator
chr15_+_23665202 4.49 ENSRNOT00000089226
sterile alpha motif domain containing 4A
chr1_+_15620653 4.37 ENSRNOT00000017401
microtubule-associated protein 7
chr18_-_56331991 4.12 ENSRNOT00000085841
ENSRNOT00000091220
solute carrier family 6 member 7
chr6_-_88232252 4.11 ENSRNOT00000047597
ribosomal protein L10-like
chr1_+_220307394 4.00 ENSRNOT00000071891
equilibrative nucleoside transporter 2
chr8_+_81949877 3.92 ENSRNOT00000030221
cAMP-regulated phosphoprotein 19-like
chr1_+_230305923 3.78 ENSRNOT00000074432
olfactory receptor 365
chr6_-_107461041 3.77 ENSRNOT00000058127
HEAT repeat containing 4
chr5_-_135285311 3.74 ENSRNOT00000088261
ENSRNOT00000085235
microtubule associated serine/threonine kinase 2
chr1_-_266333105 3.67 ENSRNOT00000027093
ADP ribosylation factor like GTPase 3
chr3_+_93648343 3.62 ENSRNOT00000091164

chr6_-_110904288 3.58 ENSRNOT00000014645
interferon regulatory factor 2 binding protein-like
chr4_+_157230769 3.57 ENSRNOT00000091464
ENSRNOT00000017472
prohibitin 2
chr4_+_57050214 3.53 ENSRNOT00000025165
adenosylhomocysteinase-like 2
chr3_+_177188044 3.40 ENSRNOT00000022073
transcription elongation factor A2
chr10_-_46145548 3.36 ENSRNOT00000033483
phospholipase D family, member 6
chr1_+_165170645 3.34 ENSRNOT00000022879
lipoyl(octanoyl) transferase 2 (putative)
chr2_+_221823687 3.11 ENSRNOT00000072735
dihydropyrimidine dehydrogenase
chr6_+_134958854 3.08 ENSRNOT00000073950
ENSRNOT00000009377
dynein cytoplasmic 1 heavy chain 1
chr10_-_43895376 3.06 ENSRNOT00000031811
olfactory receptor 1413
chr17_+_31236015 3.05 ENSRNOT00000023149
solute carrier family 22, member 23
chr17_+_5382034 3.04 ENSRNOT00000037597
golgi membrane protein 1
chr18_+_56887354 2.77 ENSRNOT00000044346
ENSRNOT00000066133
casein kinase 1, alpha 1
chr8_+_48094673 2.55 ENSRNOT00000008614
nectin cell adhesion molecule 1
chr7_+_130532435 2.41 ENSRNOT00000092672
ENSRNOT00000092535
SH3 and multiple ankyrin repeat domains 3
chr5_-_86696388 2.41 ENSRNOT00000007812
multiple EGF-like-domains 9
chr1_-_174588529 2.28 ENSRNOT00000017485
DENN domain containing 5A
chr1_-_99955717 2.24 ENSRNOT00000079624
kallikrein 1-related peptidase C6
chr2_-_187863503 2.24 ENSRNOT00000093036
ENSRNOT00000026705
ENSRNOT00000082174
lamin A/C
chr1_-_146029840 2.23 ENSRNOT00000016455
mesoderm development candidate 1
chr1_-_82108083 2.22 ENSRNOT00000027677
ENSRNOT00000084530
glycogen synthase kinase 3 alpha
chr10_+_90134193 2.18 ENSRNOT00000028375
glucose 6 phosphatase catalytic subunit 3
chr7_-_101140308 2.04 ENSRNOT00000006279
family with sequence similarity 84, member B
chr11_-_45510961 2.00 ENSRNOT00000002238
translocase of outer mitochondrial membrane 70
chr7_+_2504695 1.99 ENSRNOT00000003965
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
chr1_-_99894353 1.47 ENSRNOT00000045756
kallikrein 1-related peptidase C10
chr19_-_26181449 1.23 ENSRNOT00000036953
similar to Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-12 subunit precursor
chr3_-_8432593 1.22 ENSRNOT00000090574

chr10_-_65780349 1.21 ENSRNOT00000013220
transmembrane protein 199
chr19_-_37938857 1.21 ENSRNOT00000026730
solute carrier family 12 member 4
chr3_+_159887036 1.16 ENSRNOT00000031868
R3H domain containing-like
chr18_-_29497410 1.04 ENSRNOT00000024671
steroid receptor RNA activator 1
chr2_-_96520137 0.97 ENSRNOT00000066966
zinc finger, C2HC-type containing 1A
chr16_+_55152748 0.96 ENSRNOT00000000121
fibroblast growth factor 20
chr20_+_8325041 0.90 ENSRNOT00000000640
cap methyltransferase 1
chr9_-_16611899 0.80 ENSRNOT00000089168
male-enhanced antigen 1
chr12_+_9464026 0.79 ENSRNOT00000048188
caudal type homeo box 2
chr2_-_187149017 0.73 ENSRNOT00000092760
neurotrophic receptor tyrosine kinase 1
chr20_-_27308069 0.65 ENSRNOT00000056047
solute carrier family 25 member 16
chr12_-_41671437 0.64 ENSRNOT00000001883
LIM homeobox 5
chr1_-_80630038 0.62 ENSRNOT00000025281
translocase of outer mitochondrial membrane 40
chr16_+_60925093 0.60 ENSRNOT00000015813
tankyrase
chr9_+_121802673 0.54 ENSRNOT00000086534
YES proto-oncogene 1, Src family tyrosine kinase
chr8_-_56696968 0.54 ENSRNOT00000016637
zinc finger CCCH type containing 12C
chr1_-_266934303 0.52 ENSRNOT00000036202
calcium homeostasis modulator 3
chr18_+_56887722 0.38 ENSRNOT00000078783
casein kinase 1, alpha 1
chr11_-_83546674 0.35 ENSRNOT00000044896
Eph receptor B3
chr3_+_108795235 0.20 ENSRNOT00000007028
sprouty-related, EVH1 domain containing 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2c

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.2 51.6 GO:1990926 short-term synaptic potentiation(GO:1990926)
14.1 42.4 GO:0048378 ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
7.4 29.7 GO:0006546 glycine catabolic process(GO:0006546) glycine decarboxylation via glycine cleavage system(GO:0019464)
7.1 42.9 GO:0010045 response to nickel cation(GO:0010045)
6.9 20.7 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
6.6 19.9 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
6.0 18.1 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
6.0 17.9 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
4.8 19.0 GO:0098886 modification of dendritic spine(GO:0098886)
4.6 18.5 GO:0072086 specification of loop of Henle identity(GO:0072086)
4.2 16.9 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
4.0 11.9 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
3.8 15.2 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
3.6 25.2 GO:0016185 synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185)
3.6 10.8 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
3.6 17.9 GO:0045448 regulation of mitotic cell cycle, embryonic(GO:0009794) serotonergic neuron axon guidance(GO:0036515) mitotic cell cycle, embryonic(GO:0045448)
3.2 16.2 GO:1904045 cellular response to aldosterone(GO:1904045)
3.0 9.1 GO:0060948 neuropilin signaling pathway(GO:0038189) VEGF-activated neuropilin signaling pathway(GO:0038190) cardiac vascular smooth muscle cell development(GO:0060948) positive regulation of lymphangiogenesis(GO:1901492)
2.8 14.0 GO:0003431 growth plate cartilage chondrocyte development(GO:0003431)
2.6 7.9 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
2.6 23.2 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
2.6 10.3 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
2.5 36.9 GO:0061469 regulation of type B pancreatic cell proliferation(GO:0061469)
2.4 19.2 GO:1990034 calcium ion export from cell(GO:1990034)
2.1 27.1 GO:0042178 xenobiotic catabolic process(GO:0042178)
2.1 10.3 GO:2000672 negative regulation of motor neuron apoptotic process(GO:2000672)
2.0 6.1 GO:0009216 purine deoxyribonucleotide biosynthetic process(GO:0009153) purine deoxyribonucleoside triphosphate biosynthetic process(GO:0009216) AMP salvage(GO:0044209) adenosine biosynthetic process(GO:0046086)
2.0 5.9 GO:0021577 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589) neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
2.0 5.9 GO:0045077 negative regulation of interferon-gamma biosynthetic process(GO:0045077)
1.9 7.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.9 11.3 GO:2000630 positive regulation of miRNA metabolic process(GO:2000630)
1.8 26.7 GO:0051639 actin filament network formation(GO:0051639)
1.7 10.3 GO:0035093 spermatogenesis, exchange of chromosomal proteins(GO:0035093)
1.7 6.7 GO:0051344 negative regulation of cyclic-nucleotide phosphodiesterase activity(GO:0051344)
1.6 6.5 GO:0021586 pons maturation(GO:0021586)
1.6 15.9 GO:0007191 adenylate cyclase-activating dopamine receptor signaling pathway(GO:0007191)
1.5 4.6 GO:0015864 pyrimidine nucleoside transport(GO:0015864)
1.5 6.0 GO:0050893 sensory processing(GO:0050893)
1.5 7.3 GO:0006987 activation of signaling protein activity involved in unfolded protein response(GO:0006987) negative regulation by virus of viral protein levels in host cell(GO:0046725)
1.4 6.9 GO:0019064 fusion of virus membrane with host plasma membrane(GO:0019064) membrane fusion involved in viral entry into host cell(GO:0039663) multi-organism membrane fusion(GO:0044800)
1.3 9.4 GO:0050915 regulation of systemic arterial blood pressure by baroreceptor feedback(GO:0003025) sensory perception of sour taste(GO:0050915)
1.3 20.0 GO:0045821 positive regulation of glycolytic process(GO:0045821)
1.2 5.0 GO:0006114 glycerol biosynthetic process(GO:0006114)
1.2 10.7 GO:0006689 ganglioside catabolic process(GO:0006689)
1.1 4.5 GO:0000320 re-entry into mitotic cell cycle(GO:0000320)
1.1 3.4 GO:0030719 oocyte construction(GO:0007308) oocyte axis specification(GO:0007309) oocyte anterior/posterior axis specification(GO:0007314) pole plasm assembly(GO:0007315) maternal determination of anterior/posterior axis, embryo(GO:0008358) P granule organization(GO:0030719)
1.1 3.3 GO:0009106 lipoate metabolic process(GO:0009106)
1.1 10.9 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.0 6.3 GO:0023021 termination of signal transduction(GO:0023021)
1.0 3.1 GO:0006214 thymidine catabolic process(GO:0006214) pyrimidine deoxyribonucleoside catabolic process(GO:0046127)
1.0 16.2 GO:0060068 vagina development(GO:0060068) neuron cellular homeostasis(GO:0070050)
1.0 14.7 GO:0060134 prepulse inhibition(GO:0060134)
0.9 15.5 GO:0070262 peptidyl-serine dephosphorylation(GO:0070262)
0.9 7.2 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
0.9 9.8 GO:1990118 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.8 8.3 GO:0019372 lipoxygenase pathway(GO:0019372)
0.8 14.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.8 9.1 GO:0097623 potassium ion export across plasma membrane(GO:0097623)
0.7 9.0 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.7 2.2 GO:0044027 hypermethylation of CpG island(GO:0044027)
0.7 9.7 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.7 9.6 GO:0060033 anatomical structure regression(GO:0060033)
0.7 9.2 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.6 8.6 GO:0060088 auditory receptor cell stereocilium organization(GO:0060088)
0.6 2.4 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)
0.6 7.5 GO:0001977 renal system process involved in regulation of blood volume(GO:0001977)
0.5 14.8 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.5 5.9 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.5 3.7 GO:0042090 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.5 1.5 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105) negative regulation of adipose tissue development(GO:1904178)
0.5 6.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.5 3.5 GO:0033353 S-adenosylmethionine cycle(GO:0033353)
0.5 2.0 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.5 12.6 GO:1900449 regulation of glutamate receptor signaling pathway(GO:1900449)
0.5 13.2 GO:0001956 positive regulation of neurotransmitter secretion(GO:0001956)
0.4 14.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.4 5.9 GO:0007256 activation of JNKK activity(GO:0007256)
0.4 4.1 GO:0035524 proline transmembrane transport(GO:0035524)
0.4 6.5 GO:0000042 protein targeting to Golgi(GO:0000042)
0.4 5.4 GO:0032482 Rab protein signal transduction(GO:0032482)
0.4 4.0 GO:1901642 nucleoside transmembrane transport(GO:1901642)
0.3 2.6 GO:1902414 protein localization to cell junction(GO:1902414)
0.3 3.2 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 21.6 GO:0015909 long-chain fatty acid transport(GO:0015909)
0.3 0.6 GO:0070213 protein auto-ADP-ribosylation(GO:0070213)
0.3 0.9 GO:0036451 cap mRNA methylation(GO:0036451)
0.3 13.1 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.3 7.1 GO:0060065 uterus development(GO:0060065)
0.3 18.7 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.3 2.8 GO:0070345 negative regulation of fat cell proliferation(GO:0070345)
0.3 10.7 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.2 3.1 GO:0034063 stress granule assembly(GO:0034063)
0.2 4.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.2 2.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.2 5.2 GO:0070584 mitochondrion morphogenesis(GO:0070584)
0.2 6.4 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.2 4.5 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.2 10.3 GO:0046847 filopodium assembly(GO:0046847)
0.2 14.7 GO:0030032 lamellipodium assembly(GO:0030032)
0.2 0.7 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
0.2 0.6 GO:0021937 cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation(GO:0021937)
0.2 4.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.7 GO:0061368 behavioral response to chemical pain(GO:0061366) behavioral response to formalin induced pain(GO:0061368)
0.1 6.5 GO:0060612 adipose tissue development(GO:0060612)
0.1 7.0 GO:2001238 positive regulation of extrinsic apoptotic signaling pathway(GO:2001238)
0.1 5.8 GO:0021762 substantia nigra development(GO:0021762)
0.1 7.8 GO:0040014 regulation of multicellular organism growth(GO:0040014)
0.1 4.6 GO:0060999 positive regulation of dendritic spine development(GO:0060999)
0.1 3.7 GO:0042073 intraciliary transport(GO:0042073)
0.1 12.8 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 0.8 GO:0014807 regulation of somitogenesis(GO:0014807)
0.0 4.5 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.6 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.0 1.0 GO:0060043 regulation of cardiac muscle cell proliferation(GO:0060043)
0.0 2.3 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.4 GO:0022038 corpus callosum development(GO:0022038)
0.0 1.0 GO:2000273 positive regulation of receptor activity(GO:2000273)
0.0 2.7 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 1.2 GO:1902476 chloride transmembrane transport(GO:1902476)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
5.4 16.2 GO:0098855 HCN channel complex(GO:0098855)
5.4 16.2 GO:0005960 glycine cleavage complex(GO:0005960)
4.7 51.6 GO:0032009 early phagosome(GO:0032009)
3.4 10.3 GO:0097058 CRLF-CLCF1 complex(GO:0097058)
2.2 6.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
2.1 10.3 GO:0030868 smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425)
2.1 10.3 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
1.8 10.9 GO:0048237 rough endoplasmic reticulum lumen(GO:0048237)
1.7 19.9 GO:0098839 postsynaptic density membrane(GO:0098839)
1.5 16.9 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750)
1.5 19.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
1.3 25.2 GO:0043196 varicosity(GO:0043196)
1.2 14.0 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
1.1 17.9 GO:0032433 filopodium tip(GO:0032433)
1.1 20.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
1.1 26.7 GO:0005865 striated muscle thin filament(GO:0005865)
1.1 47.7 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
0.7 8.6 GO:0032426 stereocilium tip(GO:0032426)
0.7 14.5 GO:0030056 hemidesmosome(GO:0030056)
0.7 18.9 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.6 6.4 GO:0014731 spectrin(GO:0008091) spectrin-associated cytoskeleton(GO:0014731)
0.6 15.9 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 18.1 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.6 15.5 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.5 9.5 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.5 10.7 GO:0098563 integral component of synaptic vesicle membrane(GO:0030285) intrinsic component of synaptic vesicle membrane(GO:0098563) GABA-A receptor complex(GO:1902711)
0.4 9.7 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.4 7.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.4 6.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.4 19.0 GO:0048786 presynaptic active zone(GO:0048786)
0.4 14.6 GO:0001772 immunological synapse(GO:0001772)
0.3 23.2 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
0.3 50.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.3 2.6 GO:0032584 growth cone membrane(GO:0032584)
0.3 3.2 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 8.3 GO:0042629 mast cell granule(GO:0042629)
0.3 1.2 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.3 6.3 GO:0042599 lamellar body(GO:0042599)
0.3 6.8 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.3 5.3 GO:0005922 connexon complex(GO:0005922)
0.2 2.0 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 5.9 GO:0032839 dendrite cytoplasm(GO:0032839)
0.2 14.8 GO:0005871 kinesin complex(GO:0005871)
0.2 0.7 GO:0005760 gamma DNA polymerase complex(GO:0005760)
0.2 16.9 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.2 1.5 GO:0005638 lamin filament(GO:0005638)
0.2 6.6 GO:0044295 axonal growth cone(GO:0044295)
0.2 16.5 GO:0005604 basement membrane(GO:0005604)
0.2 6.5 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.1 25.1 GO:0043204 perikaryon(GO:0043204)
0.1 9.0 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 16.8 GO:0045211 postsynaptic membrane(GO:0045211)
0.1 34.7 GO:0043235 receptor complex(GO:0043235)
0.1 5.2 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 3.1 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 3.7 GO:0032391 photoreceptor connecting cilium(GO:0032391)
0.1 2.3 GO:0030904 retromer complex(GO:0030904)
0.1 5.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.1 3.9 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.1 8.3 GO:0031256 leading edge membrane(GO:0031256)
0.1 6.3 GO:0043197 dendritic spine(GO:0043197)
0.1 6.5 GO:0030117 membrane coat(GO:0030117) coated membrane(GO:0048475)
0.1 5.9 GO:0005903 brush border(GO:0005903)
0.1 3.9 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 8.7 GO:0030424 axon(GO:0030424)
0.0 3.5 GO:0000139 Golgi membrane(GO:0000139)
0.0 1.2 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.0 17.4 GO:0005815 microtubule organizing center(GO:0005815)
0.0 8.7 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 21.9 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 8.7 GO:0019866 organelle inner membrane(GO:0019866)
0.0 1.0 GO:0045171 intercellular bridge(GO:0045171)
0.0 5.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 53.5 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.6 42.9 GO:0008332 low voltage-gated calcium channel activity(GO:0008332)
5.4 27.1 GO:0070404 NADH binding(GO:0070404)
5.4 21.6 GO:0016416 carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416)
5.3 42.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
4.2 25.2 GO:0031749 D2 dopamine receptor binding(GO:0031749)
3.6 18.1 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
3.6 10.8 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823)
3.4 10.3 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
3.4 10.3 GO:0061628 H3K27me3 modified histone binding(GO:0061628)
2.7 19.2 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
2.6 15.9 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
2.6 7.8 GO:0070698 type I activin receptor binding(GO:0070698)
2.5 7.5 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
2.3 6.9 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
2.2 17.9 GO:0017169 CDP-alcohol phosphatidyltransferase activity(GO:0017169)
2.1 10.7 GO:0008503 benzodiazepine receptor activity(GO:0008503)
2.1 10.3 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
2.0 11.9 GO:0051430 corticotropin-releasing hormone receptor 1 binding(GO:0051430)
1.9 9.5 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
1.8 7.3 GO:0033149 FFAT motif binding(GO:0033149)
1.8 10.7 GO:0004308 exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997)
1.7 10.3 GO:0005127 ciliary neurotrophic factor receptor binding(GO:0005127)
1.6 30.8 GO:0016594 glycine binding(GO:0016594)
1.6 16.2 GO:0005222 intracellular cAMP activated cation channel activity(GO:0005222)
1.5 5.9 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
1.3 20.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
1.2 8.4 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
1.1 17.9 GO:0042813 Wnt-activated receptor activity(GO:0042813)
1.0 9.4 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
1.0 3.1 GO:0004159 dihydrouracil dehydrogenase (NAD+) activity(GO:0004159) dihydropyrimidine dehydrogenase (NADP+) activity(GO:0017113)
1.0 9.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.9 6.3 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.9 3.5 GO:0016802 adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802)
0.8 5.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.8 6.7 GO:0031545 peptidyl-proline 4-dioxygenase activity(GO:0031545)
0.8 3.3 GO:0016415 octanoyltransferase activity(GO:0016415)
0.8 5.0 GO:0098519 nucleotide phosphatase activity, acting on free nucleotides(GO:0098519)
0.8 47.1 GO:0001786 phosphatidylserine binding(GO:0001786)
0.8 14.6 GO:0033549 MAP kinase phosphatase activity(GO:0033549)
0.8 7.9 GO:0070878 primary miRNA binding(GO:0070878)
0.8 3.1 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.6 5.4 GO:0043184 vascular endothelial growth factor receptor 2 binding(GO:0043184)
0.6 8.3 GO:0045295 gamma-catenin binding(GO:0045295)
0.6 20.9 GO:0030506 ankyrin binding(GO:0030506)
0.5 15.2 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.5 19.9 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.5 30.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.5 13.1 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.5 10.9 GO:0001871 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.4 5.8 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.4 2.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.4 4.1 GO:0015193 L-proline transmembrane transporter activity(GO:0015193)
0.4 19.6 GO:0030507 spectrin binding(GO:0030507)
0.4 6.1 GO:0019206 nucleoside kinase activity(GO:0019206)
0.4 2.0 GO:0043532 angiostatin binding(GO:0043532)
0.4 4.9 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.4 19.0 GO:0048365 Rac GTPase binding(GO:0048365)
0.4 12.6 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.4 11.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.3 12.9 GO:0051879 Hsp90 protein binding(GO:0051879)
0.3 7.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.3 9.0 GO:0008376 acetylgalactosaminyltransferase activity(GO:0008376)
0.3 2.6 GO:0046790 virion binding(GO:0046790)
0.3 0.9 GO:0004483 mRNA (nucleoside-2'-O-)-methyltransferase activity(GO:0004483)
0.3 17.3 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.3 19.5 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.3 8.7 GO:0005109 frizzled binding(GO:0005109)
0.3 6.9 GO:0017091 AU-rich element binding(GO:0017091)
0.3 16.9 GO:0009055 electron carrier activity(GO:0009055)
0.3 8.3 GO:0004623 phospholipase A2 activity(GO:0004623)
0.2 13.7 GO:0019003 GDP binding(GO:0019003)
0.2 4.6 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.2 6.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.2 14.8 GO:0003777 microtubule motor activity(GO:0003777)
0.2 22.3 GO:0005179 hormone activity(GO:0005179)
0.2 9.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 0.7 GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base(GO:0016890)
0.2 4.5 GO:0070064 proline-rich region binding(GO:0070064)
0.1 1.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 2.2 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.1 1.0 GO:0010861 thyroid hormone receptor activator activity(GO:0010861)
0.1 1.2 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.1 3.4 GO:0004521 endoribonuclease activity(GO:0004521)
0.1 0.6 GO:0015266 protein channel activity(GO:0015266)
0.1 10.3 GO:0008168 methyltransferase activity(GO:0008168)
0.0 9.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 1.0 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 0.2 GO:0005173 stem cell factor receptor binding(GO:0005173)
0.0 0.6 GO:0003950 NAD+ ADP-ribosyltransferase activity(GO:0003950)
0.0 6.7 GO:0033218 amide binding(GO:0033218)
0.0 2.3 GO:0005262 calcium channel activity(GO:0005262)
0.0 3.1 GO:0008514 organic anion transmembrane transporter activity(GO:0008514)
0.0 29.8 GO:0004930 G-protein coupled receptor activity(GO:0004930)
0.0 9.7 GO:0005509 calcium ion binding(GO:0005509)
0.0 4.6 GO:0003779 actin binding(GO:0003779)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 44.1 PID GLYPICAN 1PATHWAY Glypican 1 network
1.0 25.2 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.9 11.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.8 15.9 PID LPA4 PATHWAY LPA4-mediated signaling events
0.6 10.9 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.4 21.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.4 4.5 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.4 15.5 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.4 9.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 7.9 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.3 20.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.3 6.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.3 17.4 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.3 5.4 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 7.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.2 2.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.2 7.8 PID BMP PATHWAY BMP receptor signaling
0.1 30.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.3 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.1 5.3 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 4.6 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 3.2 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.8 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 2.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 1.5 NABA COLLAGENS Genes encoding collagen proteins
0.0 0.7 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 0.4 PID EPHB FWD PATHWAY EPHB forward signaling
0.0 0.2 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.3 43.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
2.8 25.2 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
2.2 20.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
1.4 21.6 REACTOME ACTIVATED AMPK STIMULATES FATTY ACID OXIDATION IN MUSCLE Genes involved in Activated AMPK stimulates fatty-acid oxidation in muscle
1.1 11.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
1.1 15.9 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
1.0 14.6 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
0.8 6.5 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.8 34.5 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.8 19.2 REACTOME PLATELET CALCIUM HOMEOSTASIS Genes involved in Platelet calcium homeostasis
0.7 17.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.6 10.7 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.6 15.8 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.5 6.9 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
0.5 14.5 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.5 11.9 REACTOME PROSTACYCLIN SIGNALLING THROUGH PROSTACYCLIN RECEPTOR Genes involved in Prostacyclin signalling through prostacyclin receptor
0.5 17.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.4 9.0 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.4 19.5 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.4 6.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.4 5.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.3 9.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.3 7.8 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.3 8.3 REACTOME ACYL CHAIN REMODELLING OF PE Genes involved in Acyl chain remodelling of PE
0.3 3.2 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.3 5.3 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.3 12.3 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.3 7.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.3 6.8 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.2 25.3 REACTOME POTASSIUM CHANNELS Genes involved in Potassium Channels
0.2 3.1 REACTOME PYRIMIDINE CATABOLISM Genes involved in Pyrimidine catabolism
0.2 17.4 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.2 6.4 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 7.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.2 4.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 10.9 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 2.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 4.6 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.1 0.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.1 9.5 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 12.3 REACTOME TRANSMISSION ACROSS CHEMICAL SYNAPSES Genes involved in Transmission across Chemical Synapses
0.1 0.5 REACTOME CTLA4 INHIBITORY SIGNALING Genes involved in CTLA4 inhibitory signaling
0.1 1.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.1 0.8 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 7.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 3.1 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes