ISMARA results: Tfap2a

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tfap2a

Z-value: 0.98

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Transcription factors associated with Tfap2a

Gene Symbol	Gene ID	Gene Info
Tfap2a NCBI RGD Ensembl	ENSRNOG00000015522	transcription factor AP-2 alpha

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tfap2a	rn6_v1_chr17_+_24654902_24654902	0.32	3.0e-09	Click!

Activity profile of Tfap2a motif

Sorted Z-values of Tfap2a motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr14_-_60276794 Show fit	21.12	ENSRNOT00000048509	Slc34a2 NCBI RGD Ensembl Show fit	solute carrier family 34 member 2
chr17_+_22619891 Show fit	20.92	ENSRNOT00000060403	Adtrp NCBI RGD Ensembl Show fit	androgen-dependent TFPI-regulating protein
chr2_+_60920257 Show fit	18.84	ENSRNOT00000025170	C1qtnf3 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 3
chr2_-_195935878 Show fit	18.62	ENSRNOT00000028440	Cgn NCBI RGD Ensembl Show fit	cingulin
chr1_-_84145916 Show fit	18.45	ENSRNOT00000081796	Ltbp4 NCBI RGD Ensembl Show fit	latent transforming growth factor beta binding protein 4
chr1_-_80716143 Show fit	18.19	ENSRNOT00000092048 ENSRNOT00000025829	Cblc NCBI RGD Ensembl Show fit	Cbl proto-oncogene C
chr10_-_88060561 Show fit	17.65	ENSRNOT00000019133	Krt19 NCBI RGD Ensembl Show fit	keratin 19
chr10_+_104368247 Show fit	15.51	ENSRNOT00000006519	Llgl2 NCBI RGD Ensembl Show fit	LLGL2, scribble cell polarity complex component
chr4_+_120133713 Show fit	15.23	ENSRNOT00000017240	Gata2 NCBI RGD Ensembl Show fit	GATA binding protein 2
chr4_+_72718458 Show fit	14.68	ENSRNOT00000044780	Arhgef5 NCBI RGD Ensembl Show fit	Rho guanine nucleotide exchange factor 5

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.8	31.0	GO:0007175	negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
3.0	21.1	GO:0044341	sodium-dependent phosphate transport(GO:0044341)
2.7	18.9	GO:0033278	cell proliferation in midbrain(GO:0033278)
2.7	18.8	GO:0071638	negative regulation of monocyte chemotactic protein-1 production(GO:0071638)
3.9	15.5	GO:0016332	establishment or maintenance of polarity of embryonic epithelium(GO:0016332)
5.1	15.2	GO:0010725	regulation of primitive erythrocyte differentiation(GO:0010725)
2.9	14.7	GO:0002408	myeloid dendritic cell chemotaxis(GO:0002408)
0.3	14.5	GO:0070830	bicellular tight junction assembly(GO:0070830)
0.5	14.2	GO:0035313	wound healing, spreading of epidermal cells(GO:0035313)
0.4	14.2	GO:0060706	cell differentiation involved in embryonic placenta development(GO:0060706)

Showing 1 to 10 of 275 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	50.1	GO:0005578	proteinaceous extracellular matrix(GO:0005578)
0.5	43.9	GO:0044291	cell-cell contact zone(GO:0044291)
0.1	25.0	GO:0016324	apical plasma membrane(GO:0016324)
0.3	23.8	GO:0005581	collagen trimer(GO:0005581)
1.1	21.1	GO:0031528	microvillus membrane(GO:0031528)
0.3	19.3	GO:0031526	brush border membrane(GO:0031526)
0.3	18.3	GO:0031225	anchored component of membrane(GO:0031225)
2.5	17.7	GO:1990357	terminal web(GO:1990357)
0.4	17.4	GO:0016459	myosin complex(GO:0016459)
1.2	16.5	GO:0032426	stereocilium tip(GO:0032426)

Showing 1 to 10 of 122 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	31.6	GO:0008307	structural constituent of muscle(GO:0008307)
1.0	29.2	GO:0017147	Wnt-protein binding(GO:0017147)
2.1	24.7	GO:0004499	N,N-dimethylaniline monooxygenase activity(GO:0004499)
1.1	23.7	GO:0070742	C2H2 zinc finger domain binding(GO:0070742)
0.8	23.7	GO:0005385	zinc ion transmembrane transporter activity(GO:0005385)
4.2	21.1	GO:0015321	sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
2.0	20.3	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1	18.9	GO:0017137	Rab GTPase binding(GO:0017137)
0.7	18.5	GO:0050431	transforming growth factor beta binding(GO:0050431)
3.5	17.4	GO:0070052	collagen V binding(GO:0070052)

Showing 1 to 10 of 192 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	80.1	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	64.6	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	56.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.4	21.8	PID AR TF PATHWAY	Regulation of Androgen receptor activity
0.3	21.0	WNT SIGNALING	Genes related to Wnt-mediated signal transduction
0.4	20.5	PID P38 ALPHA BETA DOWNSTREAM PATHWAY	Signaling mediated by p38-alpha and p38-beta
0.4	14.7	PID INTEGRIN3 PATHWAY	Beta3 integrin cell surface interactions
0.3	14.0	PID ECADHERIN STABILIZATION PATHWAY	Stabilization and expansion of the E-cadherin adherens junction
0.5	13.9	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	12.7	PID BMP PATHWAY	BMP receptor signaling

Showing 1 to 10 of 42 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	28.2	REACTOME COLLAGEN FORMATION	Genes involved in Collagen formation
0.3	26.9	REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS	Genes involved in Class B/2 (Secretin family receptors)
0.3	23.8	REACTOME INTEGRIN CELL SURFACE INTERACTIONS	Genes involved in Integrin cell surface interactions
1.2	23.4	REACTOME ZINC TRANSPORTERS	Genes involved in Zinc transporters
0.5	22.8	REACTOME PHASE1 FUNCTIONALIZATION OF COMPOUNDS	Genes involved in Phase 1 - Functionalization of compounds
0.2	20.4	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1	17.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
0.9	17.0	REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION	Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.9	16.5	REACTOME HS GAG DEGRADATION	Genes involved in HS-GAG degradation
0.6	15.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction

Showing 1 to 10 of 75 entries

Results for Tfap2a

Z-value: 0.98

Motif logo

Transcription factors associated with Tfap2a

Activity-expression correlation:

Activity profile of Tfap2a motif

Sorted Z-values of Tfap2a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tfap2a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: