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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tead3_Tead4

Z-value: 3.09

Motif logo

Transcription factors associated with Tead3_Tead4

Gene Symbol Gene ID Gene Info
ENSRNOG00000000506 TEA domain transcription factor 3
ENSRNOG00000005608 TEA domain transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tead4rn6_v1_chr4_-_161587222_1615872220.742.0e-56Click!
Tead3rn6_v1_chr20_-_7930929_79309290.062.5e-01Click!

Activity profile of Tead3_Tead4 motif

Sorted Z-values of Tead3_Tead4 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_-_64952687 298.61 ENSRNOT00000087892
popeye domain containing 2
chr1_-_21854763 226.27 ENSRNOT00000089196
ENSRNOT00000020528
connective tissue growth factor
chr6_-_26624092 182.93 ENSRNOT00000008113
tripartite motif-containing 54
chr8_-_72841496 174.01 ENSRNOT00000057641
ENSRNOT00000040808
ENSRNOT00000085894
ENSRNOT00000024575
ENSRNOT00000048044
ENSRNOT00000024493
tropomyosin 1, alpha
chr10_+_92628356 156.52 ENSRNOT00000072480
myosin, light chain 4
chr5_+_164796185 152.86 ENSRNOT00000010779
natriuretic peptide B
chr8_-_116361343 139.40 ENSRNOT00000066296
semaphorin 3B
chr13_+_52662996 132.16 ENSRNOT00000047682
troponin T2, cardiac type
chr13_-_108841482 131.38 ENSRNOT00000004632
ENSRNOT00000086775
protein tyrosine phosphatase, non-receptor type 14
chrX_+_53053609 128.08 ENSRNOT00000058357
dystrophin
chr10_-_88874528 120.43 ENSRNOT00000026783
polymerase I and transcript release factor
chr19_+_27404712 115.93 ENSRNOT00000023657
myosin light chain kinase 3
chr1_-_252550394 111.97 ENSRNOT00000083468
actin, alpha 2, smooth muscle, aorta
chr19_-_56677084 110.31 ENSRNOT00000024084
actin, alpha 1, skeletal muscle
chr8_-_87282156 103.98 ENSRNOT00000087874
filamin A interacting protein 1
chrX_+_104734082 93.31 ENSRNOT00000005020
sushi-repeat-containing protein, X-linked 2
chr9_-_55256340 91.23 ENSRNOT00000028907
serum deprivation response
chr20_+_26988774 88.04 ENSRNOT00000090083
myopalladin
chr9_+_88357556 85.65 ENSRNOT00000020669
collagen type IV alpha 3 chain
chr4_+_56711049 82.60 ENSRNOT00000027237
filamin C
chr4_+_56711275 80.81 ENSRNOT00000088149
filamin C
chr8_+_84945444 79.09 ENSRNOT00000008244
kelch-like family member 31
chr9_-_80167033 78.83 ENSRNOT00000023530
insulin-like growth factor binding protein 5
chr9_+_52023295 77.66 ENSRNOT00000004956
collagen type III alpha 1 chain
chr13_+_89524329 77.21 ENSRNOT00000004279
myelin protein zero
chr9_-_80166807 75.56 ENSRNOT00000079493
insulin-like growth factor binding protein 5
chr8_+_55178289 75.20 ENSRNOT00000059127
crystallin, alpha B
chr10_+_86367596 74.40 ENSRNOT00000049070
ENSRNOT00000009114
ENSRNOT00000078744
erb-b2 receptor tyrosine kinase 2
chr4_-_120559078 70.48 ENSRNOT00000085730
ENSRNOT00000079575
kelch repeat and BTB domain containing 12
chr8_+_48406260 68.50 ENSRNOT00000009975
ubiquitin specific peptidase 2
chr9_-_119332967 65.36 ENSRNOT00000021048
myosin light chain 12A
chr5_+_152533349 62.69 ENSRNOT00000067524
tripartite motif containing 63
chr4_+_44597123 61.80 ENSRNOT00000078250
caveolin 1
chr8_-_84632817 61.68 ENSRNOT00000076942
muscular LMNA-interacting protein
chr2_-_257484587 60.20 ENSRNOT00000083344
nexilin (F actin binding protein)
chr13_-_70625842 59.35 ENSRNOT00000092499
laminin subunit gamma 2
chrX_+_106774980 57.65 ENSRNOT00000046091
transcription elongation factor A like 7
chr1_-_100530183 56.68 ENSRNOT00000067754
myosin binding protein C, fast-type
chr4_-_98342887 51.69 ENSRNOT00000010156
tumor-associated calcium signal transducer 2
chr4_-_82209933 51.24 ENSRNOT00000091106
homeobox protein Hox-A10-like
chr4_-_82295470 49.92 ENSRNOT00000091073
homeobox A10
chr6_-_23291568 48.97 ENSRNOT00000085708
CAP-GLY domain containing linker protein family, member 4
chr5_+_75392790 47.54 ENSRNOT00000048457
muscle associated receptor tyrosine kinase
chr2_-_147693082 45.05 ENSRNOT00000022507
WW domain containing transcription regulator 1
chr3_+_79860179 44.61 ENSRNOT00000081160
ENSRNOT00000068444
receptor-associated protein of the synapse
chrX_+_51286737 43.89 ENSRNOT00000035692
dystrophin
chr17_-_14627937 43.64 ENSRNOT00000020532
osteoglycin
chr11_-_45124423 43.52 ENSRNOT00000046383
filamin A interacting protein 1-like
chr8_-_87158368 42.83 ENSRNOT00000077071
collagen type XII alpha 1 chain
chr10_-_62699723 41.05 ENSRNOT00000086706
coronin 6
chr19_+_61677542 40.71 ENSRNOT00000014785
integrin subunit beta 1
chr5_-_152458023 40.61 ENSRNOT00000031225
connector enhancer of kinase suppressor of Ras 1
chr9_-_52238564 40.36 ENSRNOT00000005073
collagen type V alpha 2 chain
chr3_+_6430589 40.28 ENSRNOT00000012334
collagen type V alpha 1 chain
chr10_+_57322331 40.26 ENSRNOT00000041493
kinesin family member 1C
chr2_-_251532312 40.23 ENSRNOT00000019501
cysteine-rich, angiogenic inducer, 61
chr1_+_198655742 39.94 ENSRNOT00000023944
myosin light chain, phosphorylatable, fast skeletal muscle
chr3_-_177179127 39.91 ENSRNOT00000021790
SRY box 18
chr19_+_55982740 39.74 ENSRNOT00000021397
dipeptidase 1 (renal)
chr2_-_261337163 39.71 ENSRNOT00000030341
TNNI3 interacting kinase
chr1_+_42121636 39.09 ENSRNOT00000025616
myc target 1
chr6_+_12362813 38.93 ENSRNOT00000022370
stonin 1
chr4_+_181286455 38.03 ENSRNOT00000083633
PPFIA binding protein 1
chr1_+_46835971 37.06 ENSRNOT00000066798
synaptojanin 2
chr11_+_64522130 35.84 ENSRNOT00000004315
uroplakin 1B
chr7_+_14037620 34.99 ENSRNOT00000009606
synapse defective Rho GTPase homolog 1
chr7_-_98197087 34.68 ENSRNOT00000010484
ENSRNOT00000079961
kelch-like family member 38
chr15_+_86243148 34.54 ENSRNOT00000084471
ENSRNOT00000090727
LIM domain 7
chr2_+_205592182 33.95 ENSRNOT00000081050
DENN domain containing 2C
chr15_+_4064706 33.93 ENSRNOT00000011956
synaptopodin 2-like
chr8_-_62948720 33.78 ENSRNOT00000075476
immunoglobulin superfamily containing leucine-rich repeat
chr3_+_150801289 33.63 ENSRNOT00000035060
microtubule-associated protein 1 light chain 3 alpha
chr4_-_64981384 33.14 ENSRNOT00000017338
cAMP responsive element binding protein 3-like 2
chr13_-_70626252 33.02 ENSRNOT00000036947
laminin subunit gamma 2
chr15_-_33218456 32.80 ENSRNOT00000017753
ajuba LIM protein
chr14_-_6645257 32.52 ENSRNOT00000002916
polycystin 2, transient receptor potential cation channel
chr19_+_20147037 31.66 ENSRNOT00000020028
zinc finger protein 423
chr17_-_84247038 31.61 ENSRNOT00000068553
nebulette
chr9_+_50526811 29.54 ENSRNOT00000036990
similar to RIKEN cDNA 1500015O10
chr18_+_57286322 28.75 ENSRNOT00000026174
SH3 domain and tetratricopeptide repeats 2
chr2_-_219842986 27.95 ENSRNOT00000055735
amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase
chrX_+_22247088 27.65 ENSRNOT00000079802
IQ motif and Sec7 domain 2
chr20_+_3555135 27.49 ENSRNOT00000085380
discoidin domain receptor tyrosine kinase 1
chr2_-_206222248 27.26 ENSRNOT00000026075
olfactomedin-like 3
chr10_-_104358253 26.39 ENSRNOT00000005942
cask-interacting protein 2
chr7_-_92996025 26.18 ENSRNOT00000076327
sterile alpha motif domain containing 12
chr1_+_41590494 25.47 ENSRNOT00000089984
estrogen receptor 1
chr1_-_261371508 25.47 ENSRNOT00000019978
arginine vasopressin-induced 1
chr5_+_113725717 25.40 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr19_+_10519493 25.37 ENSRNOT00000030229
coiled-coil domain containing 102A
chr2_-_233743866 25.37 ENSRNOT00000087062
glutamyl aminopeptidase
chr19_-_55367353 25.34 ENSRNOT00000091139
piezo-type mechanosensitive ion channel component 1
chr7_-_81592206 24.67 ENSRNOT00000007979
angiopoietin 1
chr5_-_157268903 24.57 ENSRNOT00000022716
phospholipase A2, group V
chr10_+_15672382 24.51 ENSRNOT00000027965
rhomboid 5 homolog 1
chr2_-_44907030 24.32 ENSRNOT00000013979
glutathione peroxidase 8
chr9_+_16737642 24.23 ENSRNOT00000061430
serum response factor
chr4_-_17594598 24.17 ENSRNOT00000008936
semaphorin 3E
chr11_+_27208564 24.17 ENSRNOT00000002158
MAP3K7 C-terminal like
chr8_+_111210811 23.49 ENSRNOT00000011347
angiomotin like 2
chr1_-_189960073 23.39 ENSRNOT00000088482
crystallin, mu
chr16_+_59197367 23.33 ENSRNOT00000014924
DLC1 Rho GTPase activating protein
chr10_-_107386072 23.33 ENSRNOT00000004290
TIMP metallopeptidase inhibitor 2
chr1_-_250774105 23.12 ENSRNOT00000079227
sphingomyelin synthase 1
chr1_+_80279706 22.36 ENSRNOT00000047105
protein phosphatase 1, regulatory subunit 13 like
chr13_+_52147555 22.18 ENSRNOT00000084766
leiomodin 1
chr1_-_18058055 21.93 ENSRNOT00000020988
protein tyrosine phosphatase, receptor type, K
chr4_+_29978739 21.93 ENSRNOT00000011756
protein phosphatase 1, regulatory subunit 9A
chr1_+_85386470 21.91 ENSRNOT00000093332
ENSRNOT00000044326
pleckstrin homology and RhoGEF domain containing G2
chr6_-_99783047 21.82 ENSRNOT00000009028
spectrin, beta, erythrocytic
chr6_-_122721496 21.33 ENSRNOT00000079697
protein tyrosine phosphatase, non-receptor type 21
chr6_+_1147012 21.17 ENSRNOT00000006360
vitrin
chr7_-_144993652 20.25 ENSRNOT00000087748
integrin subunit alpha 5
chr8_+_75687100 20.21 ENSRNOT00000038677
annexin A2
chr5_+_25349928 20.19 ENSRNOT00000020826
GTP binding protein overexpressed in skeletal muscle
chr18_-_55771730 20.14 ENSRNOT00000026426
small integral membrane protein 3
chr14_-_114692764 20.02 ENSRNOT00000008210
spectrin, beta, non-erythrocytic 1
chr5_+_74649765 19.99 ENSRNOT00000075952
paralemmin 2
chr10_-_85636902 19.96 ENSRNOT00000017241
polycomb group ring finger 2
chr5_-_158439078 19.79 ENSRNOT00000025517
kelch domain containing 7A
chr10_-_56403188 19.65 ENSRNOT00000019947
cholinergic receptor nicotinic beta 1 subunit
chr1_+_218466289 19.25 ENSRNOT00000017948
MAS related GPR family member F
chrX_+_104684676 19.18 ENSRNOT00000083229
tenomodulin
chr16_-_64778486 18.75 ENSRNOT00000031701
ring finger protein 122
chr5_+_58393233 18.75 ENSRNOT00000000142
DnaJ heat shock protein family (Hsp40) member B5
chr5_+_74941802 17.88 ENSRNOT00000015576
A-kinase anchoring protein 2
chr20_+_44680449 17.88 ENSRNOT00000000728
Traf3 interacting protein 2
chrX_+_156463953 17.01 ENSRNOT00000079889
filamin A
chr5_-_139749050 16.84 ENSRNOT00000056651
nuclear transcription factor Y subunit gamma
chr6_-_21135880 16.70 ENSRNOT00000051239
RAS guanyl releasing protein 3
chr1_+_44311513 16.68 ENSRNOT00000065386
T-cell lymphoma invasion and metastasis 2
chr2_+_187737770 16.09 ENSRNOT00000036143
ENSRNOT00000092611
ENSRNOT00000092620
progestin and adipoQ receptor family member 6
chr16_+_83161880 16.00 ENSRNOT00000080793
RIKEN cDNA 1700016D06 gene
chr3_+_139894331 15.74 ENSRNOT00000064695
Ras and Rab interactor 2
chr1_+_264768105 15.72 ENSRNOT00000086766
ENSRNOT00000048843
leucine zipper tumor suppressor 2
chr5_-_102743417 15.22 ENSRNOT00000067389
basonuclin 2
chr1_-_2846200 14.91 ENSRNOT00000017688
SAM and SH3 domain containing 1
chr1_+_199163086 14.70 ENSRNOT00000025646
cardiotrophin 1
chr12_+_22451596 14.01 ENSRNOT00000072838
thyroid hormone receptor interactor 6
chr10_+_104523996 13.72 ENSRNOT00000065339
ENSRNOT00000086747
integrin subunit beta 4
chr17_+_70010794 13.70 ENSRNOT00000023945
neuroepithelial cell transforming 1
chr13_-_107886476 13.65 ENSRNOT00000077282
potassium two pore domain channel subfamily K member 2
chr14_-_60276794 13.37 ENSRNOT00000048509
solute carrier family 34 member 2
chr14_-_8432195 13.36 ENSRNOT00000089800
Rho GTPase activating protein 24
chrX_-_77675487 13.00 ENSRNOT00000042799
cysteinyl leukotriene receptor 1
chr1_-_189911571 12.83 ENSRNOT00000080996
ENSRNOT00000088536
zona pellucida glycoprotein 2
chr1_+_41323194 12.81 ENSRNOT00000026350
estrogen receptor 1
chr15_-_8914501 12.73 ENSRNOT00000008752
thyroid hormone receptor beta
chr7_+_34952011 12.17 ENSRNOT00000077666
FYVE, RhoGEF and PH domain containing 6
chr7_-_144319804 12.07 ENSRNOT00000070855
calcium-binding and coiled-coil domain-containing protein 1-like
chr19_+_568287 11.79 ENSRNOT00000016419
cadherin 16
chr1_-_131460473 11.73 ENSRNOT00000084336
nuclear receptor subfamily 2, group F, member 2
chr5_+_171478555 11.64 ENSRNOT00000091417
ENSRNOT00000000169
multiple epidermal growth factor-like domains protein 6-like
chr19_-_49448072 11.49 ENSRNOT00000014997
C-x(9)-C motif containing 2
chr12_+_40895515 10.92 ENSRNOT00000046323
protein tyrosine phosphatase, non-receptor type 11
chr3_+_160945359 10.79 ENSRNOT00000019761
phosphatidylinositol glycan anchor biosynthesis, class T
chr2_-_25235275 10.74 ENSRNOT00000061580
F2R like trypsin receptor 1
chr5_+_159845774 10.57 ENSRNOT00000012328
Eph receptor A2
chr10_-_90657185 10.46 ENSRNOT00000003685
coiled-coil domain containing 43
chr3_+_75354237 10.39 ENSRNOT00000050634
olfactory receptor 557
chr3_+_2676296 10.35 ENSRNOT00000020497
chloride intracellular channel 3
chr10_-_59049482 10.28 ENSRNOT00000078272
spinster homolog 2
chr6_-_86822094 10.23 ENSRNOT00000006531
FK506 binding protein 3
chr10_+_74874130 10.06 ENSRNOT00000076050
ENSRNOT00000044226
ENSRNOT00000085052
ENSRNOT00000076196
septin 4
chr3_-_74906989 10.05 ENSRNOT00000071001
olfactory receptor 545
chr2_+_41157823 9.80 ENSRNOT00000066384
phosphodiesterase 4D
chr10_+_74413989 9.73 ENSRNOT00000036098
spindle and kinetochore associated complex subunit 2
chrX_+_77119911 9.73 ENSRNOT00000080141
ATPase copper transporting alpha
chr2_-_193136520 9.12 ENSRNOT00000042142
keratinocyte proline-rich protein
chr13_+_34498749 8.62 ENSRNOT00000093127
cytoplasmic linker associated protein 1
chr3_-_94767239 8.42 ENSRNOT00000056808
glutamine and serine rich 1
chr7_-_143016040 8.22 ENSRNOT00000029697
keratin 80
chr9_+_54212767 8.18 ENSRNOT00000078073
ENSRNOT00000090026
glutaminase
chr1_-_31055453 8.15 ENSRNOT00000031083
SOGA family member 3
chr2_+_41442241 8.11 ENSRNOT00000067546
phosphodiesterase 4D
chr19_-_11341863 7.81 ENSRNOT00000025694
metallothionein 4
chr7_-_34951644 7.78 ENSRNOT00000030015
vezatin, adherens junctions transmembrane protein
chr1_-_215553451 7.52 ENSRNOT00000027407
cathepsin D
chr6_-_136436620 7.40 ENSRNOT00000067118
protein phosphatase 1, regulatory subunit 13B
chr20_-_3439983 7.40 ENSRNOT00000080822
ENSRNOT00000001099
immediate early response 3
chr5_-_135285311 7.39 ENSRNOT00000088261
ENSRNOT00000085235
microtubule associated serine/threonine kinase 2
chr3_+_111825162 7.31 ENSRNOT00000066685
phospholipase A2 group IVB
chr19_+_43163562 7.13 ENSRNOT00000048900
C-type lectin domain family 18, member A
chr5_+_169274785 7.12 ENSRNOT00000082586
pleckstrin homology and RhoGEF domain containing G5
chr16_+_71738718 7.07 ENSRNOT00000022097
pleckstrin homology domain containing A2
chr1_+_88078350 6.67 ENSRNOT00000048677
RAS guanyl releasing protein 4
chr2_-_219458271 6.32 ENSRNOT00000064735
cell division cycle 14A
chr3_+_75322884 6.08 ENSRNOT00000066249
olfactory receptor 556
chr6_-_136436818 6.07 ENSRNOT00000082600
protein phosphatase 1, regulatory subunit 13B
chrX_-_26376467 6.07 ENSRNOT00000051655
ENSRNOT00000036502
Rho GTPase activating protein 6
chr13_+_88265331 6.06 ENSRNOT00000031190
coiled-coil domain containing 190
chr4_+_10020349 6.03 ENSRNOT00000065039
F-box and leucine-rich repeat protein 13
chr11_+_15436269 5.98 ENSRNOT00000002150
ENSRNOT00000084928
ubiquitin specific peptidase 25
chr19_-_29968424 5.96 ENSRNOT00000024981
inositol polyphosphate-4-phosphatase type II B
chr11_-_28900376 5.69 ENSRNOT00000061606
keratin associated protein 16-5
chr4_+_157125998 5.68 ENSRNOT00000078349
complement C1r
chr15_+_105640097 5.44 ENSRNOT00000014300
muscleblind-like splicing regulator 2
chr1_-_168471161 5.43 ENSRNOT00000055227
olfactory receptor 94
chr2_-_173800761 5.40 ENSRNOT00000039524
WD repeat domain 49
chr18_-_28516209 5.39 ENSRNOT00000072580
endothelial cell surface expressed chemotaxis and apoptosis regulator

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead3_Tead4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
99.5 298.6 GO:0060931 sinoatrial node cell development(GO:0060931)
58.0 174.0 GO:0003065 positive regulation of heart rate by epinephrine(GO:0003065)
57.3 172.0 GO:0016203 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
45.3 226.3 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
44.5 222.3 GO:0090131 mesenchyme migration(GO:0090131)
44.1 132.2 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
38.6 154.4 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
25.9 77.7 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
23.2 115.9 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
21.8 152.9 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
20.6 61.8 GO:1903598 receptor-mediated endocytosis of virus by host cell(GO:0019065) endocytosis involved in viral entry into host cell(GO:0075509) regulation of inward rectifier potassium channel activity(GO:1901979) positive regulation of gap junction assembly(GO:1903598) receptor internalization involved in canonical Wnt signaling pathway(GO:2000286)
20.2 80.6 GO:1903225 negative regulation of endodermal cell differentiation(GO:1903225)
16.7 50.1 GO:0048014 Tie signaling pathway(GO:0048014)
15.8 47.5 GO:2000541 positive regulation of synaptic growth at neuromuscular junction(GO:0045887) regulation of protein geranylgeranylation(GO:2000539) positive regulation of protein geranylgeranylation(GO:2000541)
14.9 74.4 GO:0033088 negative regulation of immature T cell proliferation in thymus(GO:0033088)
14.9 44.6 GO:0090191 negative regulation of branching involved in ureteric bud morphogenesis(GO:0090191)
13.6 40.7 GO:0007161 calcium-independent cell-matrix adhesion(GO:0007161)
13.3 39.9 GO:0060214 endocardium formation(GO:0060214)
12.5 62.7 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878)
12.4 148.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
10.8 32.5 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587) renal artery morphogenesis(GO:0061441)
10.5 31.6 GO:0071691 cardiac muscle thin filament assembly(GO:0071691)
10.4 93.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
9.6 38.3 GO:1990375 baculum development(GO:1990375)
9.4 75.2 GO:0007021 tubulin complex assembly(GO:0007021)
8.3 141.9 GO:0001946 lymphangiogenesis(GO:0001946)
8.2 24.6 GO:0006663 platelet activating factor biosynthetic process(GO:0006663)
8.1 24.2 GO:1900222 negative regulation of beta-amyloid clearance(GO:1900222)
8.0 40.2 GO:0003278 apoptotic process involved in heart morphogenesis(GO:0003278)
6.7 20.2 GO:2000645 negative regulation of receptor catabolic process(GO:2000645)
6.6 85.6 GO:0032836 glomerular basement membrane development(GO:0032836)
6.3 25.4 GO:0002003 angiotensin maturation(GO:0002003)
6.3 56.7 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
6.0 17.9 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
5.9 11.7 GO:0060838 lymphatic endothelial cell fate commitment(GO:0060838) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849)
5.6 45.0 GO:0072257 metanephric nephron tubule epithelial cell differentiation(GO:0072257) regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072307)
5.6 78.0 GO:0045217 cell-cell junction maintenance(GO:0045217)
5.5 49.6 GO:1900454 positive regulation of long term synaptic depression(GO:1900454)
5.4 10.7 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
4.9 14.7 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
4.8 101.0 GO:0070831 basement membrane assembly(GO:0070831)
4.8 19.2 GO:0035990 tendon cell differentiation(GO:0035990) tendon formation(GO:0035992)
4.7 14.0 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
4.6 156.5 GO:0002026 regulation of the force of heart contraction(GO:0002026)
4.5 13.6 GO:1900039 positive regulation of cellular response to hypoxia(GO:1900039)
4.5 148.3 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
4.2 29.5 GO:0070314 G1 to G0 transition(GO:0070314)
4.1 44.6 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
4.0 68.5 GO:0048642 negative regulation of skeletal muscle tissue development(GO:0048642)
3.7 14.9 GO:1902498 regulation of protein autoubiquitination(GO:1902498)
3.7 22.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
3.6 25.3 GO:0033634 positive regulation of integrin activation(GO:0033625) positive regulation of cell-cell adhesion mediated by integrin(GO:0033634)
3.5 66.4 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
3.4 17.0 GO:0021943 formation of radial glial scaffolds(GO:0021943) regulation of membrane repolarization during cardiac muscle cell action potential(GO:1905031)
3.3 23.3 GO:1905049 negative regulation of metallopeptidase activity(GO:1905049)
3.3 23.1 GO:0006686 sphingomyelin biosynthetic process(GO:0006686)
3.3 183.1 GO:0048747 muscle fiber development(GO:0048747)
3.2 9.7 GO:0051542 elastin biosynthetic process(GO:0051542)
3.2 12.8 GO:0060468 prevention of polyspermy(GO:0060468)
2.9 61.7 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
2.9 35.0 GO:0016081 synaptic vesicle docking(GO:0016081)
2.7 10.9 GO:0033277 abortive mitotic cell cycle(GO:0033277)
2.7 8.2 GO:0006543 glutamine catabolic process(GO:0006543)
2.7 29.4 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895)
2.6 37.1 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
2.6 28.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
2.5 20.0 GO:0007182 common-partner SMAD protein phosphorylation(GO:0007182)
2.4 33.6 GO:0010040 response to iron(II) ion(GO:0010040)
2.2 39.7 GO:0050667 homocysteine metabolic process(GO:0050667)
2.2 13.0 GO:0061737 leukotriene signaling pathway(GO:0061737)
2.1 23.4 GO:0070327 thyroid hormone transport(GO:0070327)
2.1 12.7 GO:0008050 female courtship behavior(GO:0008050)
2.1 39.7 GO:1903779 regulation of cardiac conduction(GO:1903779)
2.0 10.1 GO:0030382 sperm mitochondrion organization(GO:0030382)
2.0 59.6 GO:0072661 protein targeting to plasma membrane(GO:0072661)
2.0 13.7 GO:0051451 myoblast migration(GO:0051451)
1.9 49.9 GO:0060065 uterus development(GO:0060065)
1.9 19.1 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
1.9 13.4 GO:0044341 sodium-dependent phosphate transport(GO:0044341)
1.9 24.2 GO:0001953 negative regulation of cell-matrix adhesion(GO:0001953)
1.8 5.4 GO:2000661 positive regulation of interleukin-1-mediated signaling pathway(GO:2000661)
1.7 13.7 GO:0035878 nail development(GO:0035878) trophoblast cell migration(GO:0061450)
1.7 5.0 GO:1904683 regulation of metalloendopeptidase activity(GO:1904683) positive regulation of metalloendopeptidase activity(GO:1904685)
1.6 22.4 GO:0003215 cardiac right ventricle morphogenesis(GO:0003215)
1.4 4.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
1.4 15.7 GO:0051013 microtubule severing(GO:0051013)
1.4 28.0 GO:0005980 glycogen catabolic process(GO:0005980) glucan catabolic process(GO:0009251) cellular polysaccharide catabolic process(GO:0044247)
1.3 10.3 GO:0048069 eye pigmentation(GO:0048069)
1.3 5.0 GO:1903576 response to L-arginine(GO:1903576)
1.1 31.7 GO:0030513 positive regulation of BMP signaling pathway(GO:0030513)
1.1 40.3 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.1 42.8 GO:0035987 endodermal cell differentiation(GO:0035987)
1.0 43.6 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
1.0 3.9 GO:2001199 negative regulation of dendritic cell differentiation(GO:2001199)
1.0 12.6 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.9 17.9 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.9 7.4 GO:0045075 interleukin-12 biosynthetic process(GO:0042090) regulation of interleukin-12 biosynthetic process(GO:0045075)
0.9 3.6 GO:0021502 neural fold elevation formation(GO:0021502)
0.9 2.7 GO:0045041 protein import into mitochondrial intermembrane space(GO:0045041)
0.9 27.0 GO:0051693 actin filament capping(GO:0051693)
0.9 2.6 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.8 7.4 GO:0051198 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.8 3.2 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)
0.8 3.2 GO:2001013 epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
0.8 58.5 GO:0032088 negative regulation of NF-kappaB transcription factor activity(GO:0032088)
0.7 11.8 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.7 1.4 GO:0048382 mesendoderm development(GO:0048382)
0.7 15.2 GO:0043586 tongue development(GO:0043586)
0.6 10.9 GO:0051497 negative regulation of stress fiber assembly(GO:0051497)
0.6 3.0 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.6 34.0 GO:0032233 positive regulation of actin filament bundle assembly(GO:0032233)
0.5 48.6 GO:0006986 response to unfolded protein(GO:0006986)
0.5 2.1 GO:0002282 microglial cell activation involved in immune response(GO:0002282) positive regulation of interferon-alpha biosynthetic process(GO:0045356)
0.5 6.0 GO:1904293 negative regulation of ERAD pathway(GO:1904293)
0.5 30.9 GO:0000186 activation of MAPKK activity(GO:0000186)
0.5 5.3 GO:0060693 regulation of branching involved in salivary gland morphogenesis(GO:0060693)
0.5 2.9 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.5 3.2 GO:0090527 actin filament reorganization(GO:0090527)
0.4 59.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.4 7.3 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
0.4 20.2 GO:0051310 metaphase plate congression(GO:0051310)
0.4 7.1 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.3 3.1 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.3 25.5 GO:0000187 activation of MAPK activity(GO:0000187)
0.3 52.2 GO:0007266 Rho protein signal transduction(GO:0007266)
0.3 6.7 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.3 7.5 GO:0060441 epithelial tube branching involved in lung morphogenesis(GO:0060441)
0.3 4.7 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.3 24.5 GO:0050709 negative regulation of protein secretion(GO:0050709)
0.3 20.0 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.3 2.6 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.3 6.0 GO:0045671 negative regulation of osteoclast differentiation(GO:0045671)
0.3 3.1 GO:0010801 negative regulation of peptidyl-threonine phosphorylation(GO:0010801)
0.3 24.3 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.3 1.8 GO:1902083 negative regulation of peptidyl-cysteine S-nitrosylation(GO:1902083)
0.3 2.8 GO:1990118 sodium ion import(GO:0097369) sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.3 4.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.2 10.2 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.2 2.9 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 15.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.2 2.0 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.1 16.7 GO:0007265 Ras protein signal transduction(GO:0007265)
0.1 3.8 GO:0051056 regulation of small GTPase mediated signal transduction(GO:0051056)
0.1 4.4 GO:0048536 spleen development(GO:0048536)
0.1 5.7 GO:0006956 complement activation(GO:0006956)
0.1 4.3 GO:0031122 cytoplasmic microtubule organization(GO:0031122)
0.1 29.6 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.1 12.3 GO:0051291 protein heterooligomerization(GO:0051291)
0.1 3.1 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 4.3 GO:0051101 regulation of DNA binding(GO:0051101)
0.1 1.3 GO:0006828 manganese ion transport(GO:0006828)
0.1 2.5 GO:0045669 positive regulation of osteoblast differentiation(GO:0045669)
0.1 2.7 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.1 9.1 GO:0030100 regulation of endocytosis(GO:0030100)
0.1 8.2 GO:0010506 regulation of autophagy(GO:0010506)
0.0 1.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 3.7 GO:0030198 extracellular matrix organization(GO:0030198)
0.0 33.8 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 0.9 GO:0032784 regulation of DNA-templated transcription, elongation(GO:0032784)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
33.0 132.2 GO:1990584 cardiac Troponin complex(GO:1990584)
25.7 154.4 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
24.9 174.0 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
23.1 92.4 GO:0005607 laminin-2 complex(GO:0005607)
22.4 112.0 GO:0030485 smooth muscle contractile fiber(GO:0030485)
20.2 80.6 GO:0005588 collagen type V trimer(GO:0005588)
13.6 40.7 GO:0034667 integrin alpha2-beta1 complex(GO:0034666) integrin alpha3-beta1 complex(GO:0034667)
12.5 75.2 GO:0097512 cardiac myofibril(GO:0097512)
10.7 42.8 GO:0005593 FACIT collagen trimer(GO:0005593)
10.7 85.6 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
9.7 77.7 GO:0005583 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
9.1 172.0 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) filopodium membrane(GO:0031527) glycoprotein complex(GO:0090665)
7.9 110.3 GO:0005865 striated muscle thin filament(GO:0005865)
7.4 37.1 GO:0031315 extrinsic component of mitochondrial outer membrane(GO:0031315)
6.9 61.8 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
6.4 122.0 GO:0016460 myosin II complex(GO:0016460)
6.2 74.4 GO:0043219 lateral loop(GO:0043219)
5.5 21.9 GO:1990761 growth cone lamellipodium(GO:1990761)
5.3 239.2 GO:0031672 A band(GO:0031672)
5.1 163.4 GO:0043034 costamere(GO:0043034)
4.6 32.5 GO:0071458 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
4.4 21.8 GO:0014731 spectrin-associated cytoskeleton(GO:0014731)
4.0 20.2 GO:0035749 myelin sheath adaxonal region(GO:0035749)
3.9 35.0 GO:0044300 cerebellar mossy fiber(GO:0044300)
3.8 38.3 GO:0097550 transcriptional preinitiation complex(GO:0097550)
3.8 424.6 GO:0030018 Z disc(GO:0030018)
3.8 206.8 GO:0005801 cis-Golgi network(GO:0005801)
3.7 44.6 GO:0099634 postsynaptic specialization membrane(GO:0099634)
2.9 23.1 GO:0000138 Golgi trans cisterna(GO:0000138)
2.9 20.0 GO:0001739 sex chromatin(GO:0001739)
2.8 19.7 GO:0016602 CCAAT-binding factor complex(GO:0016602)
2.7 53.1 GO:0031528 microvillus membrane(GO:0031528)
2.5 93.9 GO:0009925 basal plasma membrane(GO:0009925)
2.4 28.8 GO:0044754 autolysosome(GO:0044754)
2.2 8.6 GO:0031592 centrosomal corona(GO:0031592)
2.1 266.2 GO:0042383 sarcolemma(GO:0042383)
1.8 25.4 GO:0031983 vesicle lumen(GO:0031983)
1.8 25.3 GO:0031258 lamellipodium membrane(GO:0031258)
1.8 133.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
1.7 13.6 GO:0097449 astrocyte projection(GO:0097449)
1.7 13.5 GO:0031143 pseudopodium(GO:0031143)
1.6 65.3 GO:0016459 myosin complex(GO:0016459)
1.5 114.6 GO:0005901 caveola(GO:0005901)
1.3 7.8 GO:0002142 stereocilia ankle link complex(GO:0002142)
1.2 21.2 GO:0005614 interstitial matrix(GO:0005614)
1.0 16.7 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
1.0 19.7 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
1.0 40.1 GO:0030016 myofibril(GO:0030016)
0.9 20.2 GO:0008305 integrin complex(GO:0008305)
0.9 47.5 GO:0031594 neuromuscular junction(GO:0031594)
0.8 8.4 GO:0097227 septin complex(GO:0031105) sperm annulus(GO:0097227)
0.8 28.0 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.8 3.1 GO:0070695 FHF complex(GO:0070695)
0.7 9.7 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.7 4.7 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.6 57.1 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.6 14.3 GO:0051233 spindle midzone(GO:0051233)
0.6 34.4 GO:0005902 microvillus(GO:0005902)
0.6 8.2 GO:0030057 desmosome(GO:0030057)
0.6 198.0 GO:0015629 actin cytoskeleton(GO:0015629)
0.6 4.5 GO:0031209 SCAR complex(GO:0031209)
0.5 4.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.5 78.6 GO:0005938 cell cortex(GO:0005938)
0.5 35.3 GO:0005913 cell-cell adherens junction(GO:0005913)
0.5 50.5 GO:0030027 lamellipodium(GO:0030027)
0.5 15.4 GO:0005771 multivesicular body(GO:0005771)
0.5 2.9 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.5 27.1 GO:0005871 kinesin complex(GO:0005871)
0.5 44.2 GO:0016605 PML body(GO:0016605)
0.4 107.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.3 5.0 GO:0042588 zymogen granule(GO:0042588)
0.3 11.9 GO:0045171 intercellular bridge(GO:0045171)
0.3 0.9 GO:0031074 nucleocytoplasmic shuttling complex(GO:0031074)
0.3 0.9 GO:0044609 DBIRD complex(GO:0044609)
0.3 21.9 GO:0001750 photoreceptor outer segment(GO:0001750)
0.3 60.1 GO:0060076 excitatory synapse(GO:0060076)
0.2 29.2 GO:0055037 recycling endosome(GO:0055037)
0.2 66.3 GO:0000790 nuclear chromatin(GO:0000790)
0.2 15.7 GO:0030496 midbody(GO:0030496)
0.2 4.3 GO:0016363 nuclear matrix(GO:0016363)
0.2 88.6 GO:0048471 perinuclear region of cytoplasm(GO:0048471)
0.2 7.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.2 23.5 GO:0016324 apical plasma membrane(GO:0016324)
0.2 37.0 GO:0005925 focal adhesion(GO:0005925)
0.1 18.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.1 12.4 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 0.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 4.3 GO:0005643 nuclear pore(GO:0005643)
0.1 2.4 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 137.8 GO:0005654 nucleoplasm(GO:0005654)
0.0 5.5 GO:0005730 nucleolus(GO:0005730)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
33.0 132.2 GO:0030172 troponin C binding(GO:0030172)
29.0 115.9 GO:0004687 myosin light chain kinase activity(GO:0004687)
17.2 154.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
14.9 74.4 GO:0001042 RNA polymerase I core binding(GO:0001042)
14.0 280.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
13.6 40.7 GO:0019960 C-X3-C chemokine binding(GO:0019960)
13.2 39.7 GO:0070573 metallodipeptidase activity(GO:0070573)
13.2 39.7 GO:0031013 troponin I binding(GO:0031013)
11.7 446.1 GO:0008307 structural constituent of muscle(GO:0008307)
11.1 177.2 GO:0051371 muscle alpha-actinin binding(GO:0051371)
8.4 117.9 GO:0048407 platelet-derived growth factor binding(GO:0048407)
7.7 316.5 GO:0030552 cAMP binding(GO:0030552)
7.7 38.3 GO:0031798 type 1 metabotropic glutamate receptor binding(GO:0031798)
7.1 205.3 GO:0030506 ankyrin binding(GO:0030506)
7.0 62.7 GO:0031432 titin binding(GO:0031432)
6.9 75.5 GO:0019870 potassium channel inhibitor activity(GO:0019870)
6.6 163.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
5.7 17.0 GO:0031852 mu-type opioid receptor binding(GO:0031852)
5.3 159.7 GO:0003785 actin monomer binding(GO:0003785)
5.0 44.6 GO:0043495 protein anchor(GO:0043495)
4.9 14.7 GO:0005146 leukemia inhibitory factor receptor binding(GO:0005146)
4.7 28.0 GO:0090599 alpha-glucosidase activity(GO:0090599)
4.6 37.1 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
4.6 23.1 GO:0033188 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
4.0 20.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
3.8 53.8 GO:0005523 tropomyosin binding(GO:0005523)
3.6 25.4 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
3.5 31.9 GO:0047498 calcium-dependent phospholipase A2 activity(GO:0047498)
3.4 75.2 GO:0005212 structural constituent of eye lens(GO:0005212)
3.4 33.6 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
3.2 12.8 GO:0032190 acrosin binding(GO:0032190)
3.0 36.1 GO:0070324 thyroid hormone binding(GO:0070324)
2.9 168.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
2.8 25.3 GO:0008381 mechanically-gated ion channel activity(GO:0008381) mechanically gated channel activity(GO:0022833)
2.7 32.8 GO:0045294 alpha-catenin binding(GO:0045294)
2.7 19.1 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.7 8.2 GO:0004359 glutaminase activity(GO:0004359)
2.7 10.7 GO:0015057 thrombin receptor activity(GO:0015057)
2.7 13.4 GO:0015321 sodium-dependent phosphate transmembrane transporter activity(GO:0015321)
2.6 13.0 GO:0004974 leukotriene receptor activity(GO:0004974)
2.4 24.2 GO:0070878 primary miRNA binding(GO:0070878)
2.2 20.0 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
2.1 156.1 GO:0030971 receptor tyrosine kinase binding(GO:0030971)
2.0 6.0 GO:0016316 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316)
1.9 9.7 GO:0004008 copper-exporting ATPase activity(GO:0004008) copper-dependent protein binding(GO:0032767) copper-transporting ATPase activity(GO:0043682)
1.9 23.3 GO:0017166 vinculin binding(GO:0017166)
1.9 23.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
1.9 24.2 GO:0030215 semaphorin receptor binding(GO:0030215)
1.8 5.4 GO:0004909 interleukin-1, Type I, activating receptor activity(GO:0004909)
1.8 56.8 GO:0030332 cyclin binding(GO:0030332)
1.7 10.3 GO:0046624 sphingolipid transporter activity(GO:0046624)
1.7 26.9 GO:0035497 cAMP response element binding(GO:0035497)
1.7 91.2 GO:0005080 protein kinase C binding(GO:0005080)
1.2 31.6 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.2 122.2 GO:0019838 growth factor binding(GO:0019838)
1.2 3.6 GO:0050429 calcium-dependent phospholipase C activity(GO:0050429)
1.2 19.7 GO:0022848 acetylcholine-gated cation channel activity(GO:0022848)
1.1 27.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
1.1 25.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
1.1 58.2 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
1.1 24.3 GO:0004602 glutathione peroxidase activity(GO:0004602)
1.0 8.6 GO:0043515 kinetochore binding(GO:0043515)
0.9 40.6 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.9 30.1 GO:0042805 actinin binding(GO:0042805)
0.9 95.0 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.9 11.7 GO:0001972 retinoic acid binding(GO:0001972)
0.9 21.9 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.9 14.0 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.9 10.2 GO:0005527 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.8 2.4 GO:0001069 regulatory region RNA binding(GO:0001069)
0.7 44.8 GO:0035254 glutamate receptor binding(GO:0035254)
0.7 4.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.7 20.2 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.7 92.4 GO:0008201 heparin binding(GO:0008201)
0.6 21.2 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.6 6.1 GO:0016004 phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229)
0.5 57.8 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.5 2.6 GO:0031433 telethonin binding(GO:0031433)
0.5 3.6 GO:0070700 BMP receptor binding(GO:0070700)
0.5 2.9 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.5 7.1 GO:0001968 fibronectin binding(GO:0001968)
0.4 17.9 GO:0051018 protein kinase A binding(GO:0051018)
0.4 112.4 GO:0008017 microtubule binding(GO:0008017)
0.4 25.4 GO:0003774 motor activity(GO:0003774)
0.4 3.1 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.4 0.8 GO:0070097 delta-catenin binding(GO:0070097)
0.4 22.7 GO:0019003 GDP binding(GO:0019003)
0.4 44.1 GO:0051015 actin filament binding(GO:0051015)
0.4 6.0 GO:0032183 SUMO binding(GO:0032183)
0.3 33.9 GO:0003714 transcription corepressor activity(GO:0003714)
0.3 32.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.3 7.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.3 6.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.3 2.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.3 5.0 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.2 5.0 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 68.4 GO:0045296 cadherin binding(GO:0045296)
0.2 4.7 GO:0042169 SH2 domain binding(GO:0042169)
0.2 33.9 GO:0003779 actin binding(GO:0003779)
0.2 22.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.2 42.7 GO:0005096 GTPase activator activity(GO:0005096)
0.2 16.1 GO:0005496 steroid binding(GO:0005496)
0.2 4.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 4.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.1 1.4 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 1.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.1 1.4 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.1 8.6 GO:0051082 unfolded protein binding(GO:0051082)
0.1 132.6 GO:0005524 ATP binding(GO:0005524)
0.1 43.0 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.1 3.3 GO:0004993 G-protein coupled serotonin receptor activity(GO:0004993) serotonin receptor activity(GO:0099589)
0.1 2.1 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.9 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 30.6 GO:0004984 olfactory receptor activity(GO:0004984)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 106.1 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
6.0 286.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
4.6 226.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
4.3 180.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
3.9 74.4 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
3.8 198.6 PID RHOA PATHWAY RhoA signaling pathway
2.8 61.8 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
1.8 70.3 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
1.6 51.5 PID IL3 PATHWAY IL3-mediated signaling events
1.3 10.6 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
1.2 236.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
1.1 21.3 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
1.0 38.3 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling
1.0 29.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
1.0 13.5 SIG CHEMOTAXIS Genes related to chemotaxis
0.9 13.0 PID ENDOTHELIN PATHWAY Endothelins
0.9 16.7 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.9 47.8 PID RHOA REG PATHWAY Regulation of RhoA activity
0.9 33.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.8 23.4 PID RAS PATHWAY Regulation of Ras family activation
0.8 114.9 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.7 83.0 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.6 14.4 PID IL2 PI3K PATHWAY IL2 signaling events mediated by PI3K
0.5 7.1 PID PI3KCI PATHWAY Class I PI3K signaling events
0.5 14.0 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.5 21.9 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.5 22.4 PID P53 REGULATION PATHWAY p53 pathway
0.5 39.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.4 21.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.4 15.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 20.0 PID TGFBR PATHWAY TGF-beta receptor signaling
0.4 5.4 ST P38 MAPK PATHWAY p38 MAPK Pathway
0.3 3.2 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 4.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.3 4.4 ST GA13 PATHWAY G alpha 13 Pathway
0.3 11.7 PID TELOMERASE PATHWAY Regulation of Telomerase
0.3 7.5 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 10.2 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 3.8 PID CDC42 PATHWAY CDC42 signaling events
0.1 5.2 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.1 3.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 2.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 14.0 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.8 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
17.7 691.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
12.0 204.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
9.1 255.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
7.4 154.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
6.7 134.2 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
5.7 243.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
5.5 120.4 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
4.4 74.4 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
3.8 57.1 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
2.4 50.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
1.6 28.0 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
1.5 24.6 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
1.5 43.6 REACTOME NCAM SIGNALING FOR NEURITE OUT GROWTH Genes involved in NCAM signaling for neurite out-growth
1.2 23.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
1.1 37.3 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
1.0 13.6 REACTOME TANDEM PORE DOMAIN POTASSIUM CHANNELS Genes involved in Tandem pore domain potassium channels
1.0 42.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
1.0 23.3 REACTOME EXTRACELLULAR MATRIX ORGANIZATION Genes involved in Extracellular matrix organization
0.9 13.0 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.9 52.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.8 38.3 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.7 17.9 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.7 68.1 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.6 23.1 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.6 20.2 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.6 9.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.5 38.6 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.5 8.2 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.4 6.5 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.4 6.3 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 5.0 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.3 59.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.2 3.1 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.2 9.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.2 18.4 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 5.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 10.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 1.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.1 1.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 2.3 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.1 1.4 REACTOME DESTABILIZATION OF MRNA BY BRF1 Genes involved in Destabilization of mRNA by Butyrate Response Factor 1 (BRF1)
0.1 2.0 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 10.7 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.1 2.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import