ISMARA results: Tead3

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tead3_Tead4

Z-value: 3.09

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Transcription factors associated with Tead3_Tead4

Gene Symbol	Gene ID	Gene Info
Tead3 NCBI RGD Ensembl	ENSRNOG00000000506	TEA domain transcription factor 3
Tead4 NCBI RGD Ensembl	ENSRNOG00000005608	TEA domain transcription factor 4

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tead4	rn6_v1_chr4_-_161587222_161587222	0.74	2.0e-56	Click!
Tead3	rn6_v1_chr20_-_7930929_7930929	0.06	2.5e-01	Click!

Activity profile of Tead3_Tead4 motif

Sorted Z-values of Tead3_Tead4 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_-_64952687 Show fit	298.61	ENSRNOT00000087892	Popdc2 NCBI RGD Ensembl Show fit	popeye domain containing 2
chr1_-_21854763 Show fit	226.27	ENSRNOT00000089196 ENSRNOT00000020528	Ctgf NCBI RGD Ensembl Show fit	connective tissue growth factor
chr6_-_26624092 Show fit	182.93	ENSRNOT00000008113	Trim54 NCBI RGD Ensembl Show fit	tripartite motif-containing 54
chr8_-_72841496 Show fit	174.01	ENSRNOT00000057641 ENSRNOT00000040808 ENSRNOT00000085894 ENSRNOT00000024575 ENSRNOT00000048044 ENSRNOT00000024493	Tpm1 NCBI RGD Ensembl Show fit	tropomyosin 1, alpha
chr10_+_92628356 Show fit	156.52	ENSRNOT00000072480	Myl4 NCBI RGD Ensembl Show fit	myosin, light chain 4
chr5_+_164796185 Show fit	152.86	ENSRNOT00000010779	Nppb NCBI RGD Ensembl Show fit	natriuretic peptide B
chr8_-_116361343 Show fit	139.40	ENSRNOT00000066296	Sema3b NCBI RGD Ensembl Show fit	semaphorin 3B
chr13_+_52662996 Show fit	132.16	ENSRNOT00000047682	Tnnt2 NCBI RGD Ensembl Show fit	troponin T2, cardiac type
chr13_-_108841482 Show fit	131.38	ENSRNOT00000004632 ENSRNOT00000086775	Ptpn14 NCBI RGD Ensembl Show fit	protein tyrosine phosphatase, non-receptor type 14
chrX_+_53053609 Show fit	128.08	ENSRNOT00000058357	Dmd NCBI RGD Ensembl Show fit	dystrophin

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead3_Tead4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
99.5	298.6	GO:0060931	sinoatrial node cell development(GO:0060931)
45.3	226.3	GO:0070318	positive regulation of G0 to G1 transition(GO:0070318)
44.5	222.3	GO:0090131	mesenchyme migration(GO:0090131)
3.3	183.1	GO:0048747	muscle fiber development(GO:0048747)
58.0	174.0	GO:0003065	positive regulation of heart rate by epinephrine(GO:0003065)
57.3	172.0	GO:0016203	muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
4.6	156.5	GO:0002026	regulation of the force of heart contraction(GO:0002026)
38.6	154.4	GO:1904204	regulation of skeletal muscle hypertrophy(GO:1904204)
21.8	152.9	GO:0007168	receptor guanylyl cyclase signaling pathway(GO:0007168)
4.5	148.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)

Showing 1 to 10 of 159 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.8	424.6	GO:0030018	Z disc(GO:0030018)
2.1	266.2	GO:0042383	sarcolemma(GO:0042383)
5.3	239.2	GO:0031672	A band(GO:0031672)
3.8	206.8	GO:0005801	cis-Golgi network(GO:0005801)
0.6	198.0	GO:0015629	actin cytoskeleton(GO:0015629)
24.9	174.0	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
9.1	172.0	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) filopodium membrane(GO:0031527) glycoprotein complex(GO:0090665)
5.1	163.4	GO:0043034	costamere(GO:0043034)
25.7	154.4	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
0.1	137.8	GO:0005654	nucleoplasm(GO:0005654)

Showing 1 to 10 of 91 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.7	446.1	GO:0008307	structural constituent of muscle(GO:0008307)
7.7	316.5	GO:0030552	cAMP binding(GO:0030552)
14.0	280.2	GO:0005520	insulin-like growth factor binding(GO:0005520)
7.1	205.3	GO:0030506	ankyrin binding(GO:0030506)
11.1	177.2	GO:0051371	muscle alpha-actinin binding(GO:0051371)
2.9	168.8	GO:0005201	extracellular matrix structural constituent(GO:0005201)
6.6	163.8	GO:0051428	peptide hormone receptor binding(GO:0051428)
5.3	159.7	GO:0003785	actin monomer binding(GO:0003785)
2.1	156.1	GO:0030971	receptor tyrosine kinase binding(GO:0030971)
17.2	154.4	GO:0031995	insulin-like growth factor II binding(GO:0031995)

Showing 1 to 10 of 114 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.0	286.8	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events
1.2	236.4	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
4.6	226.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
3.8	198.6	PID RHOA PATHWAY	RhoA signaling pathway
4.3	180.4	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.8	114.9	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
6.2	106.1	PID INTEGRIN4 PATHWAY	Alpha6 beta4 integrin-ligand interactions
0.7	83.0	PID PDGFRB PATHWAY	PDGFR-beta signaling pathway
3.9	74.4	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
1.8	70.3	PID ANGIOPOIETIN RECEPTOR PATHWAY	Angiopoietin receptor Tie2-mediated signaling

Showing 1 to 10 of 44 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
17.7	691.3	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
9.1	255.2	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
5.7	243.7	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
12.0	204.1	REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS	Genes involved in Cell-extracellular matrix interactions
7.4	154.4	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
6.7	134.2	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
5.5	120.4	REACTOME RNA POL I TRANSCRIPTION TERMINATION	Genes involved in RNA Polymerase I Transcription Termination
4.4	74.4	REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING	Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.7	68.1	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.3	59.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation

Showing 1 to 10 of 44 entries

Results for Tead3_Tead4

Z-value: 3.09

Motif logo

Transcription factors associated with Tead3_Tead4

Activity-expression correlation:

Activity profile of Tead3_Tead4 motif

Sorted Z-values of Tead3_Tead4 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tead3_Tead4

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: