ISMARA results: Tcf7

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tcf7_Tcf7l2

Z-value: 0.86

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Transcription factors associated with Tcf7_Tcf7l2

Gene Symbol	Gene ID	Gene Info
Tcf7 NCBI RGD Ensembl	ENSRNOG00000005872	transcription factor 7 (T-cell specific, HMG-box)
Tcf7l2 NCBI RGD Ensembl	ENSRNOG00000049232	transcription factor 7 like 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
AABR07007000.1	rn6_v1_chr1_-_276012351_276012351	-0.10	8.2e-02	Click!
Tcf7	rn6_v1_chr10_-_37645802_37645802	-0.06	3.1e-01	Click!

Activity profile of Tcf7_Tcf7l2 motif

Sorted Z-values of Tcf7_Tcf7l2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_78985990 Show fit	35.96	ENSRNOT00000009248	Ambp NCBI RGD Ensembl Show fit	alpha-1-microglobulin/bikunin precursor
chr13_-_56877611 Show fit	34.55	ENSRNOT00000079040 ENSRNOT00000017195	Cfhr1 NCBI RGD Ensembl Show fit	complement factor H-related 1
chrX_+_143097525 Show fit	32.32	ENSRNOT00000004559	F9 NCBI RGD Ensembl Show fit	coagulation factor IX
chr4_+_65110746 Show fit	28.02	ENSRNOT00000017675	Akr1d1 NCBI RGD Ensembl Show fit	aldo-keto reductase family 1, member D1
chr10_-_109840047 Show fit	27.27	ENSRNOT00000054947	Notum NCBI RGD Ensembl Show fit	NOTUM, palmitoleoyl-protein carboxylesterase
chr7_-_143538579 Show fit	23.75	ENSRNOT00000081518	Krt79 NCBI RGD Ensembl Show fit	keratin 79
chr17_+_22619891 Show fit	21.11	ENSRNOT00000060403	Adtrp NCBI RGD Ensembl Show fit	androgen-dependent TFPI-regulating protein
chr4_+_122244711 Show fit	17.64	ENSRNOT00000038251	Uroc1 NCBI RGD Ensembl Show fit	urocanate hydratase 1
chr9_+_9721105 Show fit	17.05	ENSRNOT00000073042 ENSRNOT00000075494	C3 NCBI RGD Ensembl Show fit	complement C3
chr5_-_50193571 Show fit	16.65	ENSRNOT00000051243	Cfap206 NCBI RGD Ensembl Show fit	cilia and flagella associated protein 206

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf7_Tcf7l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	43.2	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
3.6	36.0	GO:0018298	protein-chromophore linkage(GO:0018298)
0.2	28.7	GO:0031638	zymogen activation(GO:0031638)
2.5	28.0	GO:0006707	cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
2.3	27.3	GO:0042159	lipoprotein catabolic process(GO:0042159)
0.4	26.8	GO:0003341	cilium movement(GO:0003341)
7.9	23.8	GO:0051977	lysophospholipid transport(GO:0051977)
0.3	22.9	GO:0070098	chemokine-mediated signaling pathway(GO:0070098)
5.1	20.3	GO:0019483	beta-alanine biosynthetic process(GO:0019483)
1.0	17.7	GO:0046415	urate metabolic process(GO:0046415)

Showing 1 to 10 of 182 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	126.0	GO:0072562	blood microparticle(GO:0072562)
0.1	109.5	GO:0005615	extracellular space(GO:0005615)
0.4	30.0	GO:0045095	keratin filament(GO:0045095)
0.3	18.7	GO:0005882	intermediate filament(GO:0005882)
0.7	17.4	GO:0001533	cornified envelope(GO:0001533)
2.8	16.6	GO:0005879	axonemal microtubule(GO:0005879)
0.5	15.9	GO:0097228	sperm principal piece(GO:0097228)
1.4	14.0	GO:0045179	apical cortex(GO:0045179)
0.1	12.6	GO:0036064	ciliary basal body(GO:0036064)
0.2	12.4	GO:0005778	peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)

Showing 1 to 10 of 80 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	68.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.6	62.3	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.2	37.9	GO:0001972	retinoic acid binding(GO:0001972)
7.2	36.0	GO:0019862	IgA binding(GO:0019862)
9.3	28.0	GO:0047787	delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
9.0	27.1	GO:0031714	C5a anaphylatoxin chemotactic receptor binding(GO:0031714)
0.1	22.5	GO:0052689	carboxylic ester hydrolase activity(GO:0052689)
0.5	21.1	GO:0070330	aromatase activity(GO:0070330)
0.0	20.2	GO:0005198	structural molecule activity(GO:0005198)
0.3	17.6	GO:0016836	hydro-lyase activity(GO:0016836)

Showing 1 to 10 of 139 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	109.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.7	37.9	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.9	14.7	PID ERB GENOMIC PATHWAY	Validated nuclear estrogen receptor beta network
0.2	12.5	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.5	12.2	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.3	11.3	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.1	8.5	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.3	6.3	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.2	5.1	PID BETA CATENIN DEG PATHWAY	Degradation of beta catenin
0.0	5.1	NABA SECRETED FACTORS	Genes encoding secreted soluble factors

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	42.2	REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS	Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
0.2	31.5	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
2.3	28.0	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.6	24.9	REACTOME REGULATION OF BETA CELL DEVELOPMENT	Genes involved in Regulation of beta-cell development
1.6	20.3	REACTOME PYRIMIDINE CATABOLISM	Genes involved in Pyrimidine catabolism
0.8	17.5	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.3	17.1	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
0.5	16.1	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.7	13.2	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
0.2	12.3	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 50 entries

Results for Tcf7_Tcf7l2

Z-value: 0.86

Motif logo

Transcription factors associated with Tcf7_Tcf7l2

Activity-expression correlation:

Activity profile of Tcf7_Tcf7l2 motif

Sorted Z-values of Tcf7_Tcf7l2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf7_Tcf7l2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: