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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tcf3

Z-value: 1.19

Motif logo

Transcription factors associated with Tcf3

Gene Symbol Gene ID Gene Info
ENSRNOG00000051499 transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tcf3rn6_v1_chr7_+_12144162_121441620.233.3e-05Click!

Activity profile of Tcf3 motif

Sorted Z-values of Tcf3 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_59025631 76.48 ENSRNOT00000049000
ENSRNOT00000022801
tropomyosin 2, beta
chr1_+_80321585 58.33 ENSRNOT00000022895
creatine kinase, M-type
chr4_+_144382945 51.04 ENSRNOT00000007601
caveolin 3
chr9_+_82556573 48.24 ENSRNOT00000026860
desmin
chr9_+_14529218 43.86 ENSRNOT00000016893
apolipoprotein B mRNA editing enzyme catalytic subunit 2
chr6_-_26624092 42.83 ENSRNOT00000008113
tripartite motif-containing 54
chr10_-_95934345 41.86 ENSRNOT00000004349
calcium voltage-gated channel auxiliary subunit gamma 1
chr1_-_254735548 40.55 ENSRNOT00000025258
ankyrin repeat domain 1
chr4_-_129619142 40.52 ENSRNOT00000047453
leiomodin 3
chrX_+_71342775 39.97 ENSRNOT00000004888
integrin subunit beta 1 binding protein 2
chr16_-_49574314 36.91 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
PDZ and LIM domain 3
chr13_+_52889737 36.53 ENSRNOT00000074366
calcium voltage-gated channel subunit alpha1 S
chr9_-_82699551 34.48 ENSRNOT00000020673
obscurin-like 1
chr15_+_34251606 33.84 ENSRNOT00000025725
fat storage-inducing transmembrane protein 1
chr1_+_222311253 29.97 ENSRNOT00000028749
MACRO domain containing 1
chr3_+_79860179 29.95 ENSRNOT00000081160
ENSRNOT00000068444
receptor-associated protein of the synapse
chr3_-_161246351 29.62 ENSRNOT00000020348
troponin C2, fast skeletal type
chr19_-_55510460 29.58 ENSRNOT00000019820
CBFA2/RUNX1 translocation partner 3
chr13_-_84331905 29.15 ENSRNOT00000004965
dual specificity phosphatase 27 (putative)
chr10_-_94557764 28.49 ENSRNOT00000016841
sodium voltage-gated channel alpha subunit 4
chr3_-_117766120 27.37 ENSRNOT00000056022
fibrillin 1
chr11_+_66713888 27.34 ENSRNOT00000003340
F-box protein 40
chr10_-_8498422 27.25 ENSRNOT00000082332
RNA binding protein, fox-1 homolog 1
chr1_+_167197549 26.11 ENSRNOT00000027427
ADP-ribosyltransferase 1
chr8_+_130416355 25.76 ENSRNOT00000026234
kelch-like family member 40
chr1_+_215609645 25.23 ENSRNOT00000076140
ENSRNOT00000027487
troponin I2, fast skeletal type
chr1_+_222310920 25.10 ENSRNOT00000091465
MACRO domain containing 1
chrX_-_111942749 24.50 ENSRNOT00000087583

chr1_+_215609036 24.27 ENSRNOT00000076187
troponin I2, fast skeletal type
chr11_+_27208564 24.25 ENSRNOT00000002158
MAP3K7 C-terminal like
chr13_+_52662996 23.76 ENSRNOT00000047682
troponin T2, cardiac type
chr9_-_115850634 23.56 ENSRNOT00000049720
leucine rich repeat containing 30
chr7_+_120153184 22.86 ENSRNOT00000013538
galectin 1
chrX_-_72515320 22.61 ENSRNOT00000076725
phosphorylase kinase, alpha 1
chr3_-_148407778 22.51 ENSRNOT00000011262
forkhead box S1
chr10_+_92628356 22.16 ENSRNOT00000072480
myosin, light chain 4
chr2_+_11658568 21.65 ENSRNOT00000076408
ENSRNOT00000076416
ENSRNOT00000076992
ENSRNOT00000075931
ENSRNOT00000076136
ENSRNOT00000076481
ENSRNOT00000076084
ENSRNOT00000076230
ENSRNOT00000076710
ENSRNOT00000076239
myocyte enhancer factor 2C
chr10_+_36098051 21.56 ENSRNOT00000083971
ADAM metallopeptidase with thrombospondin type 1 motif, 2
chr6_-_99783047 21.49 ENSRNOT00000009028
spectrin, beta, erythrocytic
chr3_-_72219246 21.20 ENSRNOT00000009903
smoothelin-like 1
chrX_-_72515057 21.06 ENSRNOT00000076850
ENSRNOT00000041138
phosphorylase kinase, alpha 1
chr10_-_89338739 20.83 ENSRNOT00000073923
prostaglandin E synthase 3 like
chr10_-_8654892 20.67 ENSRNOT00000066534
RNA binding protein, fox-1 homolog 1
chr15_+_4240203 20.08 ENSRNOT00000010178
MSS51 mitochondrial translational activator
chr8_-_21831668 19.98 ENSRNOT00000027897
collagen type V alpha 3 chain
chr10_+_34185898 19.75 ENSRNOT00000003339
tripartite motif-containing 7
chr1_+_220446425 19.25 ENSRNOT00000027339
endosialin-like
chr5_+_48224994 18.94 ENSRNOT00000068028
Ras-related GTP binding D
chr8_-_84632817 18.66 ENSRNOT00000076942
muscular LMNA-interacting protein
chr6_-_125723944 18.59 ENSRNOT00000007004
fibulin 5
chr16_+_6962722 18.49 ENSRNOT00000023330
musculoskeletal, embryonic nuclear protein 1
chr6_-_125723732 18.16 ENSRNOT00000084815
fibulin 5
chr2_-_88135410 17.75 ENSRNOT00000014180
carbonic anhydrase 3
chr2_+_178679395 17.53 ENSRNOT00000088686
family with sequence similarity 198, member B
chr1_-_215846911 17.45 ENSRNOT00000089171
insulin-like growth factor 2
chr1_-_265298797 17.06 ENSRNOT00000023137
DNA polymerase lambda
chr4_+_57952982 16.86 ENSRNOT00000014465
carboxypeptidase A1
chr18_-_31430973 16.68 ENSRNOT00000026065
protocadherin 12
chr8_-_62948720 16.46 ENSRNOT00000075476
immunoglobulin superfamily containing leucine-rich repeat
chr1_+_220353356 16.36 ENSRNOT00000080189
CD248 molecule
chr13_+_85818427 16.30 ENSRNOT00000077227
ENSRNOT00000006117
retinoid X receptor gamma
chr1_+_266952561 16.27 ENSRNOT00000076452
neuralized E3 ubiquitin protein ligase 1
chr4_-_82202096 15.97 ENSRNOT00000081824
homeobox protein Hox-A10-like
chr8_+_22368745 15.23 ENSRNOT00000049973
solute carrier family 44 member 2
chr20_+_3553455 14.88 ENSRNOT00000090080
discoidin domain receptor tyrosine kinase 1
chr2_-_172361779 14.77 ENSRNOT00000085876
schwannomin interacting protein 1
chr1_+_220362064 14.59 ENSRNOT00000074361
endosialin
chr8_+_39997875 14.35 ENSRNOT00000050609
endothelial cell adhesion molecule
chr1_-_89559960 14.14 ENSRNOT00000092133
sodium voltage-gated channel beta subunit 1
chr19_-_43911057 13.99 ENSRNOT00000026017
chymotrypsinogen B1
chr10_-_89816491 13.80 ENSRNOT00000028220
mesenchyme homeobox 1
chr8_-_49025917 13.75 ENSRNOT00000078816
pleckstrin homology-like domain, family B, member 1
chr3_+_5624506 13.64 ENSRNOT00000036995
ADAMTS-like 2
chr10_-_18063391 13.48 ENSRNOT00000072297
fibroblast growth factor 18
chr5_-_48436531 13.47 ENSRNOT00000060914
peptidase M20 domain containing 2
chrX_+_63520991 13.46 ENSRNOT00000071590
apolipoprotein O
chr1_+_101884276 13.31 ENSRNOT00000082917
transmembrane protein 143
chr6_+_6427657 13.17 ENSRNOT00000005664
protein kinase domain containing, cytoplasmic
chr1_-_128695995 13.17 ENSRNOT00000077020
synemin
chr11_+_3119885 13.16 ENSRNOT00000042316
vestigial-like family member 3
chr10_+_54126486 13.16 ENSRNOT00000078820
growth arrest specific 7
chr3_-_80933283 13.14 ENSRNOT00000007771
cAMP responsive element binding protein 3-like 1
chr3_-_110556808 13.11 ENSRNOT00000092158
ENSRNOT00000045362
similar to hypothetical protein
chr6_-_86822094 12.81 ENSRNOT00000006531
FK506 binding protein 3
chr3_-_7141522 12.75 ENSRNOT00000014572
carboxyl ester lipase
chr4_+_70689737 12.61 ENSRNOT00000018852
protease, serine, 2
chr18_+_25163561 12.59 ENSRNOT00000042287
ENSRNOT00000049898
ENSRNOT00000017573
bridging integrator 1
chr15_+_39945095 12.41 ENSRNOT00000016826
shisa family member 2
chr5_+_169181418 12.30 ENSRNOT00000004508
kelch-like family member 21
chr13_-_91020112 12.30 ENSRNOT00000030449
dual specificity phosphatase 23
chr6_+_98284170 12.26 ENSRNOT00000031979
ras homolog family member J
chr9_+_111028824 11.99 ENSRNOT00000041418
ENSRNOT00000056457
peptidylglycine alpha-amidating monooxygenase
chr4_-_160605107 11.68 ENSRNOT00000090725
tetraspanin 9
chrX_-_159841072 11.65 ENSRNOT00000001158
Rac/Cdc42 guanine nucleotide exchange factor 6
chr2_-_231521052 11.61 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chrX_+_53360839 11.38 ENSRNOT00000091467
ENSRNOT00000034372
ENSRNOT00000081061
dystrophin
chr4_-_14490446 11.36 ENSRNOT00000009132
semaphorin 3C
chr9_+_111028575 11.28 ENSRNOT00000043451
peptidylglycine alpha-amidating monooxygenase
chr14_+_60764409 11.19 ENSRNOT00000005168
leucine-rich repeat LGI family, member 2
chr16_-_71319449 11.10 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr16_-_71319052 11.00 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr13_-_111581018 10.89 ENSRNOT00000083072
ENSRNOT00000077981
SERTA domain containing 4
chr11_+_46009322 10.84 ENSRNOT00000002233
transmembrane protein 45A
chr4_-_38240848 10.82 ENSRNOT00000007567
NADH:ubiquinone oxidoreductase subunit A4
chr16_-_59721227 10.78 ENSRNOT00000015166
PEAK1 related kinase activating pseudokinase 1
chr9_+_82700468 10.65 ENSRNOT00000027227
inhibin alpha subunit
chr11_+_46714355 10.47 ENSRNOT00000073404
transmembrane protein 45A-like
chr7_+_123043503 10.43 ENSRNOT00000026258
ENSRNOT00000086355
TEF, PAR bZIP transcription factor
chrX_-_25628272 10.28 ENSRNOT00000086414
midline 1
chr20_+_18780605 10.28 ENSRNOT00000000754
BicC family RNA binding protein 1
chr2_-_105089659 10.15 ENSRNOT00000043381
carboxypeptidase B1
chr3_-_9037942 10.07 ENSRNOT00000036770
immediate early response 5-like
chr5_-_79874671 9.94 ENSRNOT00000084563
tenascin C
chr15_+_37806836 9.72 ENSRNOT00000076285
interleukin 17D
chr10_-_110101872 9.72 ENSRNOT00000071893
coiled-coil domain containing 57
chr3_-_5617225 9.65 ENSRNOT00000008327
transmembrane protein 8C
chr20_+_40236437 9.53 ENSRNOT00000000743
heparan sulfate-glucosamine 3-sulfotransferase 5
chr5_+_75392790 9.45 ENSRNOT00000048457
muscle associated receptor tyrosine kinase
chr8_-_116993193 9.41 ENSRNOT00000026327
dystroglycan 1
chr9_+_42871950 9.34 ENSRNOT00000089673
AT-rich interaction domain 5A
chr7_+_122157201 9.31 ENSRNOT00000025193
adenylosuccinate lyase
chr7_-_139223116 9.21 ENSRNOT00000086559
endonuclease, poly(U)-specific
chr19_-_56772904 9.08 ENSRNOT00000024232
ATP binding cassette subfamily B member 10
chr1_-_277867630 9.03 ENSRNOT00000054679
ENSRNOT00000091038
ENSRNOT00000079869
actin-binding LIM protein 1
chr5_-_144274981 8.98 ENSRNOT00000065871
MAP7 domain containing 1
chr4_-_147163467 8.82 ENSRNOT00000010748
tissue inhibitor of metalloproteinase 4
chr5_+_147476221 8.78 ENSRNOT00000010730
syncoilin, intermediate filament protein
chr10_-_82197848 8.72 ENSRNOT00000081307
calcium voltage-gated channel subunit alpha1 G
chr18_+_52215682 8.69 ENSRNOT00000037901
multiple EGF-like domains 10
chr9_+_82571269 8.58 ENSRNOT00000026941
SPEG complex locus
chr8_-_22874637 8.55 ENSRNOT00000064551
ENSRNOT00000090424
dedicator of cytokinesis 6
chr18_+_24708115 8.51 ENSRNOT00000061054
LIM zinc finger domain containing 2
chr10_+_104451222 8.48 ENSRNOT00000088665
ENSRNOT00000071694
small integral membrane protein 5
chr3_+_11207542 8.41 ENSRNOT00000013546
proline-rich coiled-coil 2B
chr10_+_94566928 8.36 ENSRNOT00000078446
proline rich 29
chr4_+_129574264 8.33 ENSRNOT00000010185
ADP-ribosylation factor like GTPase 6 interacting protein 5
chr1_-_260638816 8.24 ENSRNOT00000065632
ENSRNOT00000017938
ENSRNOT00000077962
phosphoinositide-3-kinase adaptor protein 1
chr14_+_13192347 8.12 ENSRNOT00000000092
anthrax toxin receptor 2
chr2_-_257376756 8.02 ENSRNOT00000065811
GIPC PDZ domain containing family, member 2
chr8_-_53146953 8.00 ENSRNOT00000045356
zinc finger and BTB domain containing 16
chr12_+_24473981 7.97 ENSRNOT00000001973
frizzled class receptor 9
chr4_-_159697207 7.95 ENSRNOT00000086440
cyclin D2
chr1_-_277768368 7.93 ENSRNOT00000023113
actin filament associated protein 1-like 2
chr13_-_35048444 7.77 ENSRNOT00000009963
GLI family zinc finger 2
chr14_-_104523297 7.73 ENSRNOT00000039523
centrosomal protein 68
chr4_-_70747226 7.72 ENSRNOT00000044960
anionic trypsin-2-like
chr6_-_21135880 7.54 ENSRNOT00000051239
RAS guanyl releasing protein 3
chrX_-_16929907 7.52 ENSRNOT00000003971
shroom family member 4
chr4_-_82215022 7.49 ENSRNOT00000010256
homeobox A11
chr16_-_81912738 7.49 ENSRNOT00000087095
MCF.2 cell line derived transforming sequence-like
chr7_+_59349745 7.43 ENSRNOT00000085334
protein tyrosine phosphatase, receptor type, B
chr5_+_156215417 7.37 ENSRNOT00000067616
ENSRNOT00000077742
endothelin converting enzyme 1
chr12_-_38995570 7.35 ENSRNOT00000001806
ORAI calcium release-activated calcium modulator 1
chr4_+_83713666 7.31 ENSRNOT00000086473
cAMP responsive element binding protein 5
chr1_-_19376301 7.29 ENSRNOT00000015547
Rho GTPase activating protein 18
chr1_-_214971929 7.28 ENSRNOT00000027195
MOB kinase activator 2
chr10_+_109446444 7.11 ENSRNOT00000066736
BAH domain and coiled-coil containing 1
chr8_-_22974321 7.05 ENSRNOT00000017369
erythropoietin receptor
chr20_-_49486550 7.05 ENSRNOT00000048270
ENSRNOT00000076541
PR/SET domain 1
chr1_+_72420352 7.04 ENSRNOT00000066307
SH3 domain binding kinase family, member 3
chr15_+_23792931 7.02 ENSRNOT00000092091
sterile alpha motif domain containing 4A
chr20_-_4863198 7.01 ENSRNOT00000001108
lymphotoxin beta
chr9_+_84689150 6.98 ENSRNOT00000072242
potassium voltage-gated channel subfamily E regulatory subunit 4
chr17_+_44794130 6.88 ENSRNOT00000077571
histone cluster 1, H2ac
chr3_-_60166013 6.79 ENSRNOT00000024922
WAS/WASL interacting protein family, member 1
chr5_-_164959851 6.66 ENSRNOT00000012301
F-box protein 6
chr18_+_79813759 6.60 ENSRNOT00000021768
zinc finger protein 516
chr20_-_4863011 6.56 ENSRNOT00000079503
lymphotoxin beta
chr1_+_101214593 6.42 ENSRNOT00000028086
TEA domain transcription factor 2
chr9_-_82419288 6.41 ENSRNOT00000004797
tubulin, alpha 4A
chr6_+_35314444 6.41 ENSRNOT00000005666
odd-skipped related transciption factor 1
chr3_+_58084606 6.38 ENSRNOT00000084797
methionyl aminopeptidase type 1D (mitochondrial)
chr2_+_198417619 6.15 ENSRNOT00000085945
histone cluster 2, H3c2
chr2_+_198390166 6.14 ENSRNOT00000081042
histone cluster 2, H3c2
chr19_+_52032886 6.03 ENSRNOT00000019923
malonyl-CoA decarboxylase
chrX_-_111191932 6.01 ENSRNOT00000088050
ENSRNOT00000083613
MORC family CW-type zinc finger 4
chr1_+_78546012 6.01 ENSRNOT00000058172
G protein subunit gamma 5
chrX_-_134866210 5.95 ENSRNOT00000005331
apelin
chr13_+_52147555 5.85 ENSRNOT00000084766
leiomodin 1
chr16_-_19918644 5.82 ENSRNOT00000083345
ENSRNOT00000023926
plasmalemma vesicle associated protein
chr15_-_61772516 5.70 ENSRNOT00000015605
ENSRNOT00000093399
WW domain binding protein 4
chr4_+_71795768 5.64 ENSRNOT00000031921
taste receptor, type 2, member 135
chr5_+_18901039 5.63 ENSRNOT00000012066
family with sequence similarity 110, member B
chr10_-_90312386 5.62 ENSRNOT00000028445
solute carrier family 4 member 1
chr10_+_104359342 5.55 ENSRNOT00000006327
tRNA splicing endonuclease subunit 54
chr10_+_90930010 5.51 ENSRNOT00000003765
HIG1 hypoxia inducible domain family, member 1B
chr2_-_174413038 5.47 ENSRNOT00000089229
ENSRNOT00000037115
golgi integral membrane protein 4
chr10_+_59173268 5.45 ENSRNOT00000013486
ubiquitin-conjugating enzyme E2G 1
chr7_+_3332788 5.42 ENSRNOT00000010180
Cd63 molecule
chr12_-_25638797 5.29 ENSRNOT00000002033
GATS protein-like 2
chr4_+_181481147 5.27 ENSRNOT00000002523
kelch-like family, member 42
chrX_-_70233073 5.27 ENSRNOT00000004048
acyl-CoA wax alcohol acyltransferase 2
chr19_-_37907714 5.21 ENSRNOT00000026361
chymotrypsin-like
chr1_+_128924966 5.18 ENSRNOT00000019267
insulin-like growth factor 1 receptor
chr4_-_19413484 5.15 ENSRNOT00000009489
semaphorin 3D
chr14_+_36047144 5.04 ENSRNOT00000003088
ligand of numb-protein X 1
chr4_-_70628470 4.98 ENSRNOT00000029319
trypsin 5
chr2_+_201172312 4.91 ENSRNOT00000026458
tryptophanyl tRNA synthetase 2 (mitochondrial)
chr10_-_88307412 4.90 ENSRNOT00000089933
junction plakoglobin
chr10_-_88307132 4.90 ENSRNOT00000040845
junction plakoglobin

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 55.1 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
12.8 51.0 GO:0035995 detection of muscle stretch(GO:0035995)
11.0 43.9 GO:0016554 cytidine to uridine editing(GO:0016554)
9.1 27.4 GO:2001205 negative regulation of osteoclast development(GO:2001205)
7.9 23.8 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
7.4 22.1 GO:0035607 ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
5.8 23.3 GO:0031179 peptide modification(GO:0031179)
5.8 46.4 GO:0051694 pointed-end actin filament capping(GO:0051694)
5.7 11.4 GO:0003350 pulmonary myocardium development(GO:0003350)
5.4 21.6 GO:2000111 positive regulation of macrophage apoptotic process(GO:2000111) epithelial cell proliferation involved in renal tubule morphogenesis(GO:2001013)
5.2 36.5 GO:0002074 extraocular skeletal muscle development(GO:0002074)
4.9 34.5 GO:0071688 striated muscle myosin thick filament assembly(GO:0071688)
4.8 33.8 GO:0010890 positive regulation of sequestering of triglyceride(GO:0010890)
4.6 18.5 GO:1902730 positive regulation of proteoglycan biosynthetic process(GO:1902730)
4.6 22.9 GO:0002317 plasma cell differentiation(GO:0002317)
4.5 13.5 GO:2000546 positive regulation of cell chemotaxis to fibroblast growth factor(GO:1904849) positive regulation of endothelial cell chemotaxis to fibroblast growth factor(GO:2000546)
4.4 43.7 GO:0006657 CDP-choline pathway(GO:0006657)
4.3 4.3 GO:0070315 G1 to G0 transition involved in cell differentiation(GO:0070315)
4.2 12.6 GO:0060988 lipid tube assembly(GO:0060988)
3.8 19.1 GO:0098528 skeletal muscle fiber differentiation(GO:0098528)
3.8 11.4 GO:0016203 muscle attachment(GO:0016203) olfactory nerve morphogenesis(GO:0021627) olfactory nerve structural organization(GO:0021629)
3.7 51.9 GO:0071340 skeletal muscle acetylcholine-gated channel clustering(GO:0071340)
3.7 36.8 GO:0048251 elastic fiber assembly(GO:0048251)
3.6 28.5 GO:0015871 choline transport(GO:0015871)
3.5 7.1 GO:1904373 response to kainic acid(GO:1904373)
3.3 9.9 GO:0060447 bud outgrowth involved in lung branching(GO:0060447)
3.3 29.6 GO:1903715 regulation of aerobic respiration(GO:1903715)
3.2 9.6 GO:0014908 myotube differentiation involved in skeletal muscle regeneration(GO:0014908)
3.2 6.4 GO:0036023 embryonic skeletal limb joint morphogenesis(GO:0036023)
3.2 9.5 GO:0015015 heparan sulfate proteoglycan biosynthetic process, enzymatic modification(GO:0015015)
3.2 18.9 GO:1904263 positive regulation of TORC1 signaling(GO:1904263)
3.1 9.3 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
2.9 11.6 GO:0036371 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
2.8 14.1 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
2.8 13.8 GO:0061056 somite specification(GO:0001757) sclerotome development(GO:0061056)
2.7 47.9 GO:0035994 response to muscle stretch(GO:0035994)
2.6 13.2 GO:0031443 fast-twitch skeletal muscle fiber contraction(GO:0031443)
2.6 7.8 GO:0021508 floor plate formation(GO:0021508)
2.5 47.9 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
2.5 17.5 GO:0038028 insulin receptor signaling pathway via phosphatidylinositol 3-kinase(GO:0038028)
2.3 25.8 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
2.2 13.2 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
2.2 13.1 GO:0070278 extracellular matrix constituent secretion(GO:0070278)
2.2 8.7 GO:0014816 skeletal muscle satellite cell activation(GO:0014719) skeletal muscle satellite cell differentiation(GO:0014816)
2.1 27.9 GO:1904259 regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197)
2.1 6.4 GO:0070084 protein initiator methionine removal(GO:0070084)
2.1 8.3 GO:0002036 regulation of L-glutamate transport(GO:0002036)
2.0 6.0 GO:0033869 coenzyme A catabolic process(GO:0015938) nucleoside bisphosphate catabolic process(GO:0033869) ribonucleoside bisphosphate catabolic process(GO:0034031) purine nucleoside bisphosphate catabolic process(GO:0034034) fatty-acyl-CoA catabolic process(GO:0036115)
2.0 8.0 GO:0048133 germ-line stem cell division(GO:0042078) male germ-line stem cell asymmetric division(GO:0048133) germline stem cell asymmetric division(GO:0098728)
2.0 9.8 GO:0002159 desmosome assembly(GO:0002159)
1.9 48.2 GO:0045109 intermediate filament organization(GO:0045109)
1.9 74.0 GO:0003009 skeletal muscle contraction(GO:0003009)
1.7 5.2 GO:1903943 regulation of hepatocyte apoptotic process(GO:1903943) negative regulation of hepatocyte apoptotic process(GO:1903944)
1.7 13.6 GO:0060481 lobar bronchus epithelium development(GO:0060481)
1.7 8.5 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
1.6 4.9 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
1.6 41.8 GO:0070296 sarcoplasmic reticulum calcium ion transport(GO:0070296)
1.6 98.6 GO:0043462 regulation of ATPase activity(GO:0043462)
1.5 4.6 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
1.5 10.7 GO:0046882 negative regulation of follicle-stimulating hormone secretion(GO:0046882)
1.5 6.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
1.5 5.9 GO:0043396 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
1.5 8.7 GO:0010045 response to nickel cation(GO:0010045)
1.4 49.0 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
1.4 5.6 GO:0000379 tRNA-type intron splice site recognition and cleavage(GO:0000379)
1.3 3.9 GO:0061552 vestibulocochlear nerve structural organization(GO:0021649) ganglion morphogenesis(GO:0061552) dorsal root ganglion morphogenesis(GO:1904835)
1.2 2.5 GO:1904412 canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of cardiac ventricle development(GO:1904412)
1.2 3.7 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
1.2 15.8 GO:0045741 positive regulation of epidermal growth factor-activated receptor activity(GO:0045741)
1.2 8.2 GO:0034154 toll-like receptor 7 signaling pathway(GO:0034154)
1.1 5.6 GO:0010037 response to carbon dioxide(GO:0010037)
1.1 8.8 GO:0051045 negative regulation of membrane protein ectodomain proteolysis(GO:0051045)
1.1 58.3 GO:0042398 cellular modified amino acid biosynthetic process(GO:0042398)
1.0 3.1 GO:1904879 positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
1.0 12.3 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
1.0 7.0 GO:0051136 regulation of NK T cell differentiation(GO:0051136)
1.0 17.1 GO:0048535 lymph node development(GO:0048535)
1.0 26.1 GO:0006471 protein ADP-ribosylation(GO:0006471)
1.0 12.8 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
1.0 10.7 GO:0060272 embryonic skeletal joint morphogenesis(GO:0060272)
1.0 2.9 GO:2001226 negative regulation of chloride transport(GO:2001226)
1.0 4.8 GO:0006287 base-excision repair, gap-filling(GO:0006287)
0.9 16.7 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.9 12.8 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.8 4.2 GO:0008295 spermidine biosynthetic process(GO:0008295)
0.8 13.5 GO:0042407 cristae formation(GO:0042407)
0.8 4.8 GO:2000504 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.8 14.8 GO:0008210 estrogen metabolic process(GO:0008210)
0.8 17.9 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.8 1.5 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
0.8 4.5 GO:0072658 maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660)
0.8 3.8 GO:1900108 negative regulation of nodal signaling pathway(GO:1900108)
0.8 6.8 GO:1902237 positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902237) positive regulation of type B pancreatic cell apoptotic process(GO:2000676)
0.7 17.7 GO:0006730 one-carbon metabolic process(GO:0006730)
0.7 21.5 GO:0006779 porphyrin-containing compound biosynthetic process(GO:0006779)
0.7 7.7 GO:0010457 centriole-centriole cohesion(GO:0010457)
0.7 5.4 GO:2000680 regulation of rubidium ion transport(GO:2000680)
0.6 1.9 GO:0098909 regulation of cardiac muscle cell action potential involved in regulation of contraction(GO:0098909)
0.6 16.3 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.6 4.9 GO:0034351 negative regulation of glial cell apoptotic process(GO:0034351)
0.6 8.0 GO:0071481 cellular response to X-ray(GO:0071481)
0.6 9.0 GO:0040037 negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037)
0.6 7.1 GO:0031507 heterochromatin assembly(GO:0031507)
0.6 2.9 GO:0051612 negative regulation of neurotransmitter uptake(GO:0051581) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612)
0.6 4.6 GO:0061193 taste bud development(GO:0061193)
0.5 21.6 GO:0030199 collagen fibril organization(GO:0030199)
0.5 22.5 GO:0040018 positive regulation of multicellular organism growth(GO:0040018)
0.5 2.5 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.5 2.5 GO:0007621 negative regulation of female receptivity(GO:0007621)
0.5 6.4 GO:0048368 lateral mesoderm development(GO:0048368)
0.5 1.5 GO:0003057 regulation of the force of heart contraction by chemical signal(GO:0003057)
0.5 4.8 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.5 21.2 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.5 29.8 GO:0000186 activation of MAPKK activity(GO:0000186)
0.5 12.3 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.4 1.8 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.4 6.7 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.4 5.8 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
0.4 8.3 GO:0002115 store-operated calcium entry(GO:0002115)
0.4 10.3 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.4 5.5 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.4 12.3 GO:0034629 cellular protein complex localization(GO:0034629)
0.4 8.8 GO:0045103 intermediate filament-based process(GO:0045103)
0.3 2.8 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.3 7.9 GO:0061098 positive regulation of protein tyrosine kinase activity(GO:0061098)
0.3 2.6 GO:0035021 negative regulation of Rac protein signal transduction(GO:0035021)
0.3 1.0 GO:0014043 negative regulation of neuron maturation(GO:0014043)
0.3 13.9 GO:0060612 adipose tissue development(GO:0060612)
0.3 14.9 GO:0032094 response to food(GO:0032094)
0.3 19.8 GO:0030032 lamellipodium assembly(GO:0030032)
0.3 1.7 GO:0043619 regulation of transcription from RNA polymerase II promoter in response to oxidative stress(GO:0043619)
0.3 7.5 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.3 35.3 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.3 5.7 GO:0045292 mRNA cis splicing, via spliceosome(GO:0045292)
0.3 11.3 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.3 2.4 GO:0032836 glomerular basement membrane development(GO:0032836)
0.2 4.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 1.1 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.2 1.8 GO:0014029 neural crest formation(GO:0014029)
0.2 2.2 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.2 6.5 GO:0035025 positive regulation of Rho protein signal transduction(GO:0035025)
0.2 1.4 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.2 3.9 GO:0030574 collagen catabolic process(GO:0030574)
0.2 18.6 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.2 3.6 GO:0033599 regulation of mammary gland epithelial cell proliferation(GO:0033599)
0.2 1.5 GO:0090286 cytoskeletal anchoring at nuclear membrane(GO:0090286)
0.2 8.6 GO:0055013 cardiac muscle cell development(GO:0055013)
0.2 0.9 GO:0030311 poly-N-acetyllactosamine metabolic process(GO:0030309) poly-N-acetyllactosamine biosynthetic process(GO:0030311)
0.2 3.1 GO:0048747 muscle fiber development(GO:0048747)
0.2 4.0 GO:0010842 retina layer formation(GO:0010842)
0.2 0.6 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.2 19.4 GO:0007160 cell-matrix adhesion(GO:0007160)
0.2 0.5 GO:1902269 positive regulation of polyamine transmembrane transport(GO:1902269)
0.2 1.5 GO:0043536 positive regulation of blood vessel endothelial cell migration(GO:0043536)
0.2 16.1 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 9.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.1 2.5 GO:0035767 endothelial cell chemotaxis(GO:0035767)
0.1 1.1 GO:0021860 pyramidal neuron development(GO:0021860)
0.1 5.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 1.0 GO:0097264 self proteolysis(GO:0097264)
0.1 1.3 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.3 GO:0001502 cartilage condensation(GO:0001502)
0.1 0.6 GO:0031033 myosin filament organization(GO:0031033) myosin filament assembly(GO:0031034)
0.1 3.0 GO:0042462 gamma-aminobutyric acid signaling pathway(GO:0007214) eye photoreceptor cell development(GO:0042462)
0.1 19.2 GO:0006470 protein dephosphorylation(GO:0006470)
0.1 10.8 GO:1902600 hydrogen ion transmembrane transport(GO:1902600)
0.1 1.6 GO:0007602 phototransduction(GO:0007602)
0.1 1.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.1 1.4 GO:0097031 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 3.1 GO:1901998 toxin transport(GO:1901998)
0.1 8.2 GO:0030041 actin filament polymerization(GO:0030041)
0.1 4.4 GO:0006334 nucleosome assembly(GO:0006334)
0.1 1.8 GO:0098927 early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927)
0.1 2.7 GO:0048286 lung alveolus development(GO:0048286)
0.1 7.6 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.0 3.6 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 3.6 GO:0006342 chromatin silencing(GO:0006342)
0.0 1.5 GO:0006611 protein export from nucleus(GO:0006611)
0.0 3.1 GO:0007338 single fertilization(GO:0007338)
0.0 0.8 GO:0045739 positive regulation of DNA repair(GO:0045739)
0.0 0.1 GO:0031627 telomeric loop formation(GO:0031627) regulation of DNA strand elongation(GO:0060382) positive regulation of DNA strand elongation(GO:0060383)
0.0 0.3 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.0 1.4 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.9 GO:0035176 social behavior(GO:0035176) intraspecies interaction between organisms(GO:0051703)
0.0 0.1 GO:0051198 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
0.0 0.7 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 1.9 GO:0046546 male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546)
0.0 0.4 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.0 1.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
10.9 76.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
9.6 48.1 GO:0045098 type III intermediate filament(GO:0045098)
8.6 102.9 GO:0005861 troponin complex(GO:0005861)
7.4 36.8 GO:0071953 elastic fiber(GO:0071953)
5.7 34.5 GO:1990393 3M complex(GO:1990393)
5.5 43.7 GO:0005964 phosphorylase kinase complex(GO:0005964)
5.0 20.0 GO:0005588 collagen type V trimer(GO:0005588)
3.8 71.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
3.6 10.7 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673) inhibin complex(GO:0043511)
3.1 21.5 GO:0008091 spectrin(GO:0008091)
2.6 13.2 GO:0060053 neurofilament cytoskeleton(GO:0060053)
2.5 27.4 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
2.5 9.8 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
2.2 121.2 GO:0031672 A band(GO:0031672)
2.1 6.4 GO:0071149 TEAD-2-YAP complex(GO:0071149)
2.1 42.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
2.0 90.3 GO:0005891 voltage-gated calcium channel complex(GO:0005891)
2.0 6.0 GO:0031680 G-protein beta/gamma-subunit complex(GO:0031680)
1.9 13.5 GO:0061617 MICOS complex(GO:0061617)
1.8 12.3 GO:0005827 polar microtubule(GO:0005827)
1.5 4.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
1.5 20.0 GO:0099634 postsynaptic specialization membrane(GO:0099634)
1.5 172.4 GO:0031674 I band(GO:0031674)
1.4 5.4 GO:0097487 multivesicular body, internal vesicle(GO:0097487)
1.3 36.3 GO:0030017 sarcomere(GO:0030017)
1.2 7.4 GO:0033093 Weibel-Palade body(GO:0033093)
1.2 4.8 GO:0031592 centrosomal corona(GO:0031592)
1.1 13.8 GO:0045180 basal cortex(GO:0045180)
1.1 5.6 GO:0000214 tRNA-intron endonuclease complex(GO:0000214)
1.1 7.5 GO:0016460 myosin II complex(GO:0016460)
1.0 5.2 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
1.0 1.9 GO:0044307 dendritic branch(GO:0044307)
0.8 6.7 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.7 3.7 GO:1990452 Parkin-FBXW7-Cul1 ubiquitin ligase complex(GO:1990452)
0.7 10.8 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.6 2.5 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.6 7.8 GO:0097542 ciliary tip(GO:0097542)
0.6 9.9 GO:0005614 interstitial matrix(GO:0005614)
0.5 7.5 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.5 4.1 GO:0005677 chromatin silencing complex(GO:0005677)
0.4 12.3 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 12.8 GO:0042588 zymogen granule(GO:0042588)
0.4 2.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.4 1.8 GO:0070695 FHF complex(GO:0070695)
0.3 10.3 GO:0097440 apical dendrite(GO:0097440)
0.3 2.8 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.3 2.4 GO:0005587 collagen type IV trimer(GO:0005587) network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.3 2.4 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.3 20.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.3 8.1 GO:0001891 phagocytic cup(GO:0001891)
0.3 4.6 GO:0030061 mitochondrial crista(GO:0030061)
0.3 53.2 GO:0005802 trans-Golgi network(GO:0005802)
0.2 1.1 GO:1990604 IRE1-TRAF2-ASK1 complex(GO:1990604)
0.2 1.5 GO:0042382 paraspeckles(GO:0042382)
0.2 14.2 GO:0031594 neuromuscular junction(GO:0031594)
0.2 1.5 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.2 2.2 GO:0031527 filopodium membrane(GO:0031527)
0.2 1.5 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.2 1.3 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.2 4.5 GO:0031528 microvillus membrane(GO:0031528)
0.2 19.0 GO:0016605 PML body(GO:0016605)
0.2 12.1 GO:0000786 nucleosome(GO:0000786)
0.2 14.1 GO:0005884 actin filament(GO:0005884)
0.2 21.2 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.2 9.1 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.2 7.3 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 9.0 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.1 1.5 GO:0044613 nuclear pore central transport channel(GO:0044613) nuclear pore nuclear basket(GO:0044615)
0.1 15.1 GO:0031225 anchored component of membrane(GO:0031225)
0.1 8.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 1.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 3.0 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 2.5 GO:0031907 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 5.7 GO:0005776 autophagosome(GO:0005776)
0.1 7.3 GO:0005901 caveola(GO:0005901)
0.1 0.9 GO:0032426 stereocilium tip(GO:0032426)
0.1 136.6 GO:0005615 extracellular space(GO:0005615)
0.1 30.1 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.1 10.8 GO:0001650 fibrillar center(GO:0001650)
0.1 1.2 GO:0030137 COPI-coated vesicle(GO:0030137)
0.0 16.0 GO:0016607 nuclear speck(GO:0016607)
0.0 1.8 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 3.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.1 GO:0035869 ciliary transition zone(GO:0035869)
0.0 4.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 2.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.6 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 13.7 GO:0005730 nucleolus(GO:0005730)
0.0 1.1 GO:0030139 endocytic vesicle(GO:0030139)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 23.8 GO:0030172 troponin C binding(GO:0030172)
8.7 43.7 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
8.3 58.3 GO:0004111 creatine kinase activity(GO:0004111)
8.1 32.6 GO:0016842 amidine-lyase activity(GO:0016842)
7.3 43.9 GO:0004126 cytidine deaminase activity(GO:0004126)
7.1 49.5 GO:0031014 troponin T binding(GO:0031014)
6.4 51.0 GO:0071253 connexin binding(GO:0071253)
4.8 67.6 GO:0005523 tropomyosin binding(GO:0005523)
4.4 8.7 GO:0086056 voltage-gated calcium channel activity involved in AV node cell action potential(GO:0086056) voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
4.3 12.8 GO:0050253 retinyl-palmitate esterase activity(GO:0050253)
4.1 40.5 GO:0031432 titin binding(GO:0031432)
4.0 181.8 GO:0008307 structural constituent of muscle(GO:0008307)
3.8 22.9 GO:0048030 disaccharide binding(GO:0048030)
3.3 29.9 GO:0043495 protein anchor(GO:0043495)
3.3 26.1 GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956)
2.8 14.1 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
2.8 22.1 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.7 16.3 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
2.7 13.6 GO:0043120 tumor necrosis factor binding(GO:0043120)
2.7 13.5 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
2.7 18.8 GO:0038062 protein tyrosine kinase collagen receptor activity(GO:0038062)
2.4 17.1 GO:0051575 5'-deoxyribose-5-phosphate lyase activity(GO:0051575)
2.2 17.7 GO:0016151 nickel cation binding(GO:0016151)
2.1 39.7 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
1.7 13.8 GO:0003680 AT DNA binding(GO:0003680)
1.6 4.9 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
1.5 10.7 GO:0034711 inhibin binding(GO:0034711)
1.3 5.3 GO:0050252 retinol O-fatty-acyltransferase activity(GO:0050252)
1.3 41.9 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
1.2 9.9 GO:0045545 syndecan binding(GO:0045545)
1.2 8.7 GO:0001849 complement component C1q binding(GO:0001849)
1.2 28.5 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
1.2 27.1 GO:0030506 ankyrin binding(GO:0030506)
1.2 4.9 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.1 5.6 GO:0000213 tRNA-intron endonuclease activity(GO:0000213)
1.1 28.0 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
1.1 50.4 GO:0019213 deacetylase activity(GO:0019213)
0.9 12.5 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.9 13.1 GO:0035497 cAMP response element binding(GO:0035497)
0.9 17.5 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.9 11.3 GO:0005528 macrolide binding(GO:0005527) FK506 binding(GO:0005528)
0.9 5.2 GO:0043559 insulin binding(GO:0043559)
0.9 101.2 GO:0005178 integrin binding(GO:0005178)
0.8 9.8 GO:0045294 alpha-catenin binding(GO:0045294)
0.8 8.8 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.8 41.4 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.8 4.5 GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294)
0.7 12.6 GO:0048156 tau protein binding(GO:0048156)
0.7 3.7 GO:0050816 phosphothreonine binding(GO:0050816)
0.7 4.4 GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467)
0.7 11.4 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.7 3.3 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.7 3.9 GO:0005021 vascular endothelial growth factor-activated receptor activity(GO:0005021)
0.6 7.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.6 8.4 GO:0016805 dipeptidase activity(GO:0016805)
0.6 2.9 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
0.6 1.7 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.6 4.6 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.6 7.9 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.5 4.8 GO:0043515 kinetochore binding(GO:0043515)
0.5 13.3 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.5 14.8 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.5 13.6 GO:0003785 actin monomer binding(GO:0003785)
0.5 9.2 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.5 8.3 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.5 8.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.4 14.8 GO:0043394 proteoglycan binding(GO:0043394)
0.4 0.4 GO:0015016 [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016)
0.4 4.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 15.4 GO:0050840 extracellular matrix binding(GO:0050840)
0.4 5.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.4 2.8 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.4 1.9 GO:0031849 olfactory receptor binding(GO:0031849)
0.4 10.8 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.3 6.4 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.3 1.5 GO:0043532 angiostatin binding(GO:0043532)
0.3 11.6 GO:0030507 spectrin binding(GO:0030507)
0.3 20.4 GO:0019003 GDP binding(GO:0019003)
0.3 6.4 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.2 3.0 GO:0005024 transforming growth factor beta-activated receptor activity(GO:0005024) protein-hormone receptor activity(GO:0016500)
0.2 1.5 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.2 2.2 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445)
0.2 13.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 26.5 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.2 5.5 GO:0005545 1-phosphatidylinositol binding(GO:0005545)
0.2 2.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
0.2 3.0 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
0.2 0.9 GO:0008532 N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity(GO:0008532)
0.2 28.9 GO:0051015 actin filament binding(GO:0051015)
0.2 1.5 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 19.1 GO:0001191 transcriptional repressor activity, RNA polymerase II transcription factor binding(GO:0001191)
0.2 39.7 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.2 41.2 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.2 5.9 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 19.6 GO:0003714 transcription corepressor activity(GO:0003714)
0.2 0.5 GO:0042978 ornithine decarboxylase activator activity(GO:0042978)
0.1 6.0 GO:0016831 carboxy-lyase activity(GO:0016831)
0.1 30.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 25.1 GO:0008022 protein C-terminus binding(GO:0008022)
0.1 1.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 27.6 GO:0008017 microtubule binding(GO:0008017)
0.1 1.3 GO:0051400 BH domain binding(GO:0051400)
0.1 35.1 GO:0000987 core promoter proximal region sequence-specific DNA binding(GO:0000987)
0.1 3.8 GO:0004714 transmembrane receptor protein tyrosine kinase activity(GO:0004714)
0.1 7.3 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 2.6 GO:0015485 cholesterol binding(GO:0015485)
0.1 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.1 1.1 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.0 2.4 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 1.8 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 0.7 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 3.7 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.7 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.1 GO:0019863 IgE binding(GO:0019863)
0.0 4.9 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.7 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)
0.0 0.1 GO:1990955 G-rich single-stranded DNA binding(GO:1990955)
0.0 2.8 GO:0003779 actin binding(GO:0003779)
0.0 5.2 GO:0005549 odorant binding(GO:0005549)
0.0 3.4 GO:0016757 transferase activity, transferring glycosyl groups(GO:0016757)
0.0 0.7 GO:0004004 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 45.3 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
1.4 27.4 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
1.3 9.4 ST PAC1 RECEPTOR PATHWAY PAC1 Receptor Pathway
0.9 17.1 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.9 72.0 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.9 40.5 PID AURORA B PATHWAY Aurora B signaling
0.8 9.2 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.8 6.9 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells
0.7 31.9 PID NCADHERIN PATHWAY N-cadherin signaling events
0.7 29.6 PID ERBB4 PATHWAY ErbB4 signaling events
0.6 8.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.5 4.9 PID TXA2PATHWAY Thromboxane A2 receptor signaling
0.5 15.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.5 7.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.5 9.9 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.5 13.7 PID FGF PATHWAY FGF signaling pathway
0.5 22.4 NABA COLLAGENS Genes encoding collagen proteins
0.5 19.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.4 3.9 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.4 20.4 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.4 7.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.3 7.9 PID EPO PATHWAY EPO signaling pathway
0.3 4.5 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 5.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.2 15.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.2 8.2 PID BCR 5PATHWAY BCR signaling pathway
0.2 12.8 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.2 4.5 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.2 8.6 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 43.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 8.9 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
0.2 6.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.2 41.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2 25.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 2.5 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.1 1.7 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 1.5 PID ALK2 PATHWAY ALK2 signaling events
0.1 2.2 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 1.5 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 1.1 PID INSULIN PATHWAY Insulin Pathway
0.0 1.5 PID BMP PATHWAY BMP receptor signaling
0.0 1.8 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.0 0.7 PID IL4 2PATHWAY IL4-mediated signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 13.5 REACTOME FGFR2C LIGAND BINDING AND ACTIVATION Genes involved in FGFR2c ligand binding and activation
6.7 261.1 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
4.3 38.7 REACTOME DEFENSINS Genes involved in Defensins
2.2 43.7 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
1.8 64.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
1.7 22.1 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
1.2 50.8 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
1.1 10.7 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
1.0 41.5 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.9 21.6 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.8 17.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 9.3 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.7 8.3 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.7 11.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.6 15.2 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.4 8.2 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.4 9.0 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.4 5.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.4 4.2 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.4 47.0 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.4 29.5 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.4 10.0 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.4 2.9 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.4 8.8 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.3 3.9 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 10.3 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.3 64.0 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.3 4.4 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 4.9 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 9.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.2 5.3 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.2 4.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.2 1.6 REACTOME OPSINS Genes involved in Opsins
0.2 3.3 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.2 10.8 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 6.1 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 1.2 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 8.9 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 3.6 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.1 5.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.1 4.5 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 3.0 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.1 2.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.1 1.5 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 2.2 REACTOME IL RECEPTOR SHC SIGNALING Genes involved in Interleukin receptor SHC signaling
0.1 0.9 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.1 1.7 REACTOME REGULATION OF HYPOXIA INDUCIBLE FACTOR HIF BY OXYGEN Genes involved in Regulation of Hypoxia-inducible Factor (HIF) by Oxygen
0.1 9.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.1 1.5 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.0 2.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.2 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR