ISMARA results: Tcf21

Project

GSE53960: rat RNA-Seq transcriptomic Bodymap

Navigation

Downloads

Results for Tcf21_Msc

Z-value: 1.04

Motif logo

Transcription factors associated with Tcf21_Msc

Gene Symbol	Gene ID	Gene Info
Tcf21 NCBI RGD Ensembl	ENSRNOG00000016700	transcription factor 21
Msc NCBI RGD Ensembl	ENSRNOG00000007540	musculin

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Msc	rn6_v1_chr5_+_3955227_3955227	0.37	1.5e-11	Click!
Tcf21	rn6_v1_chr1_+_23906717_23906717	-0.10	6.2e-02	Click!

Activity profile of Tcf21_Msc motif

Sorted Z-values of Tcf21_Msc motif

Top targets:

Search:

Show entries

Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr6_-_127248372 Show fit	66.77	ENSRNOT00000085517	Asb2 NCBI RGD Ensembl Show fit	ankyrin repeat and SOCS box-containing 2
chr4_+_144382945 Show fit	61.11	ENSRNOT00000007601	Cav3 NCBI RGD Ensembl Show fit	caveolin 3
chr1_+_80321585 Show fit	52.40	ENSRNOT00000022895	Ckm NCBI RGD Ensembl Show fit	creatine kinase, M-type
chr15_-_33656089 Show fit	51.42	ENSRNOT00000024186	Myh7 NCBI RGD Ensembl Show fit	myosin heavy chain 7
chr10_+_92628356 Show fit	40.50	ENSRNOT00000072480	Myl4 NCBI RGD Ensembl Show fit	myosin, light chain 4
chr13_-_84331905 Show fit	35.82	ENSRNOT00000004965	Dusp27 NCBI RGD Ensembl Show fit	dual specificity phosphatase 27 (putative)
chr13_-_52197205 Show fit	30.11	ENSRNOT00000009712	Shisa4 NCBI RGD Ensembl Show fit	shisa family member 4
chr11_+_36555416 Show fit	29.22	ENSRNOT00000064981	Sh3bgr NCBI RGD Ensembl Show fit	SH3 domain binding glutamate-rich protein
chr2_-_45518502 Show fit	27.72	ENSRNOT00000014627	Hspb3 NCBI RGD Ensembl Show fit	heat shock protein family B (small) member 3
chrX_+_71342775 Show fit	27.22	ENSRNOT00000004888	Itgb1bp2 NCBI RGD Ensembl Show fit	integrin subunit beta 1 binding protein 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf21_Msc

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.9	76.8	GO:0035914	skeletal muscle cell differentiation(GO:0035914)
18.2	72.7	GO:0014724	regulation of twitch skeletal muscle contraction(GO:0014724)
15.3	61.1	GO:2001288	detection of muscle stretch(GO:0035995) positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.9	48.9	GO:0042398	cellular modified amino acid biosynthetic process(GO:0042398)
1.4	40.7	GO:0002026	regulation of the force of heart contraction(GO:0002026)
5.8	40.6	GO:0002074	extraocular skeletal muscle development(GO:0002074)
0.1	27.8	GO:0006470	protein dephosphorylation(GO:0006470)
1.7	23.8	GO:0055003	cardiac myofibril assembly(GO:0055003)
0.7	23.3	GO:0007026	negative regulation of microtubule depolymerization(GO:0007026)
3.8	23.1	GO:0060723	regulation of spongiotrophoblast cell proliferation(GO:0060721) regulation of cell proliferation involved in embryonic placenta development(GO:0060723)

Showing 1 to 10 of 217 entries

Gene overrepresentation in cellular component category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.8	98.7	GO:0031674	I band(GO:0031674)
6.5	78.4	GO:0005859	muscle myosin complex(GO:0005859)
8.3	66.8	GO:0031466	Cul5-RING ubiquitin ligase complex(GO:0031466)
1.3	62.8	GO:0031672	A band(GO:0031672)
3.3	62.4	GO:0016010	dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.1	34.3	GO:0016607	nuclear speck(GO:0016607)
1.1	23.8	GO:0036379	striated muscle thin filament(GO:0005865) myofilament(GO:0036379)
7.0	21.1	GO:1990015	mesaxon(GO:0097453) ensheathing process(GO:1990015)
1.0	20.4	GO:0001518	voltage-gated sodium channel complex(GO:0001518)
6.2	18.6	GO:0090534	longitudinal sarcoplasmic reticulum(GO:0014801) calcium ion-transporting ATPase complex(GO:0090534)

Showing 1 to 10 of 100 entries

Gene overrepresentation in molecular function category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	69.8	GO:0061630	ubiquitin protein ligase activity(GO:0061630)
7.6	61.1	GO:0071253	connexin binding(GO:0071253)
7.5	52.4	GO:0004111	creatine kinase activity(GO:0004111)
3.4	48.0	GO:0030898	actin-dependent ATPase activity(GO:0030898)
0.8	43.9	GO:0008138	protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
2.6	36.1	GO:0031432	titin binding(GO:0031432)
4.9	29.7	GO:0032027	myosin light chain binding(GO:0032027)
2.1	27.0	GO:0097493	structural molecule activity conferring elasticity(GO:0097493)
0.2	23.0	GO:0004713	protein tyrosine kinase activity(GO:0004713)
0.2	22.4	GO:0051015	actin filament binding(GO:0051015)

Showing 1 to 10 of 142 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
2.5	61.1	PID PDGFRA PATHWAY	PDGFR-alpha signaling pathway
0.4	31.8	PID RB 1PATHWAY	Regulation of retinoblastoma protein
0.4	21.1	PID TNF PATHWAY	TNF receptor signaling pathway
0.5	15.3	PID RETINOIC ACID PATHWAY	Retinoic acid receptors-mediated signaling
0.5	14.3	PID IGF1 PATHWAY	IGF1 pathway
0.4	12.7	PID MYC PATHWAY	C-MYC pathway
0.4	11.4	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.9	10.3	ST INTERFERON GAMMA PATHWAY	Interferon gamma pathway.
0.2	8.7	NABA PROTEOGLYCANS	Genes encoding proteoglycans
0.2	8.7	PID SYNDECAN 1 PATHWAY	Syndecan-1-mediated signaling events

Showing 1 to 10 of 34 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Search:

Show entries

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	90.7	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.4	55.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
1.8	33.3	REACTOME PRE NOTCH PROCESSING IN GOLGI	Genes involved in Pre-NOTCH Processing in Golgi
0.2	29.2	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
1.0	19.0	REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS	Genes involved in Glycogen breakdown (glycogenolysis)
0.4	17.4	REACTOME GLYCOLYSIS	Genes involved in Glycolysis
0.5	16.3	REACTOME INTERACTION BETWEEN L1 AND ANKYRINS	Genes involved in Interaction between L1 and Ankyrins
0.2	15.3	REACTOME PPARA ACTIVATES GENE EXPRESSION	Genes involved in PPARA Activates Gene Expression
0.3	14.9	REACTOME NCAM1 INTERACTIONS	Genes involved in NCAM1 interactions
1.0	14.3	REACTOME SIGNAL ATTENUATION	Genes involved in Signal attenuation

Showing 1 to 10 of 60 entries

Results for Tcf21_Msc

Z-value: 1.04

Motif logo

Transcription factors associated with Tcf21_Msc

Activity-expression correlation:

Activity profile of Tcf21_Msc motif

Sorted Z-values of Tcf21_Msc motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tcf21_Msc

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: