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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx5

Z-value: 0.97

Motif logo

Transcription factors associated with Tbx5

Gene Symbol Gene ID Gene Info
ENSRNOG00000001399 T-box 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx5rn6_v1_chr12_+_42097626_420976260.392.9e-13Click!

Activity profile of Tbx5 motif

Sorted Z-values of Tbx5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr18_+_53609214 85.37 ENSRNOT00000077443
solute carrier family 27 member 6
chr6_-_2311781 29.87 ENSRNOT00000084171
cytochrome P450, family 1, subfamily b, polypeptide 1
chr8_+_62779875 27.24 ENSRNOT00000010831
cytochrome P450, family 11, subfamily a, polypeptide 1
chr2_+_230901126 25.54 ENSRNOT00000016026
ENSRNOT00000015564
ENSRNOT00000068198
calcium/calmodulin-dependent protein kinase II delta
chr10_-_91661558 24.60 ENSRNOT00000043156

chr5_+_164808323 22.48 ENSRNOT00000011005
natriuretic peptide A
chr8_-_107952530 21.00 ENSRNOT00000052043
claudin 18
chr10_+_107455845 20.51 ENSRNOT00000004373
C1q and tumor necrosis factor related protein 1
chr1_+_156552328 19.38 ENSRNOT00000055401
discs large MAGUK scaffold protein 2
chrX_+_33443186 18.75 ENSRNOT00000005622
S100 calcium binding protein G
chr1_-_236729412 17.61 ENSRNOT00000054794
prune homolog 2
chr4_+_120133713 16.45 ENSRNOT00000017240
GATA binding protein 2
chr7_-_116255167 14.95 ENSRNOT00000038109
ENSRNOT00000041774
cytochrome P450, family 11, subfamily b, polypeptide 2
chr2_-_189856090 14.64 ENSRNOT00000020307
natriuretic peptide receptor 1
chr10_-_56511583 13.72 ENSRNOT00000021402
similar to RIKEN cDNA 2810408A11
chr20_+_44436403 13.41 ENSRNOT00000000733
ENSRNOT00000076859
FYN proto-oncogene, Src family tyrosine kinase
chr1_-_98521551 13.32 ENSRNOT00000081922
sialic acid binding Ig-like lectin 10
chr5_+_157222636 13.29 ENSRNOT00000022579
phospholipase A2, group IID
chr4_-_115015965 12.99 ENSRNOT00000014603
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr2_+_93792601 12.52 ENSRNOT00000014701
ENSRNOT00000077311
fatty acid binding protein 4
chr5_-_57896475 12.48 ENSRNOT00000017903
similar to testes development-related NYD-SP22 isoform 1
chr11_+_33863500 12.26 ENSRNOT00000072384
carbonyl reductase [NADPH] 1-like
chr10_+_54156649 12.24 ENSRNOT00000074718
growth arrest specific 7
chr4_-_158010166 12.24 ENSRNOT00000026633
CD9 molecule
chr11_+_33845463 12.23 ENSRNOT00000041838
carbonyl reductase 1
chr1_+_100501676 12.22 ENSRNOT00000043724
family with sequence similarity 71, member E1
chr11_+_33812989 12.00 ENSRNOT00000042283
ENSRNOT00000075985
carbonyl reductase 1
chr1_+_143675985 11.92 ENSRNOT00000078500
transmembrane 6 superfamily member 1
chr1_+_213595240 11.89 ENSRNOT00000017137
secretoglobin, family 1C, member 1
chrX_-_123601100 11.88 ENSRNOT00000092546
ENSRNOT00000092301
septin 6
chr6_-_138744480 11.86 ENSRNOT00000089387

chr1_-_98521706 11.74 ENSRNOT00000015941
sialic acid binding Ig-like lectin 10
chr16_-_8564379 11.63 ENSRNOT00000060975
hypothetical protein LOC680885
chr16_+_26906716 11.56 ENSRNOT00000064297
carboxypeptidase E
chr7_-_12635943 11.09 ENSRNOT00000015029
complement factor D
chr10_+_69434941 10.71 ENSRNOT00000009756
C-C motif chemokine ligand 11
chr1_+_203160323 10.67 ENSRNOT00000027919

chr15_+_32894938 10.53 ENSRNOT00000012837
abhydrolase domain containing 4
chr1_-_178195948 10.44 ENSRNOT00000081767
BTB domain containing 10
chr3_-_164388492 10.20 ENSRNOT00000090493
transmembrane protein 189
chr9_-_80167033 10.19 ENSRNOT00000023530
insulin-like growth factor binding protein 5
chr10_-_82887497 10.12 ENSRNOT00000005644
integrin subunit alpha 3
chr9_-_80166807 9.82 ENSRNOT00000079493
insulin-like growth factor binding protein 5
chr11_+_33812662 9.67 ENSRNOT00000085961
carbonyl reductase [NADPH] 1-like
chr2_+_174013288 9.64 ENSRNOT00000013904
serpin family I member 1
chr8_-_116361343 9.08 ENSRNOT00000066296
semaphorin 3B
chr1_-_53087474 9.06 ENSRNOT00000017302
C-C motif chemokine receptor 6
chr6_-_137733026 9.03 ENSRNOT00000019213
jagged 2
chr5_+_151436464 8.80 ENSRNOT00000012463
mitogen-activated protein kinase kinase kinase 6
chr10_-_70735742 8.56 ENSRNOT00000077035
HEAT repeat containing 9
chr1_-_271256379 8.44 ENSRNOT00000081605
inositol 1,4,5-trisphosphate receptor-interacting protein-like
chr13_+_52662996 8.44 ENSRNOT00000047682
troponin T2, cardiac type
chr4_+_147275334 8.24 ENSRNOT00000051858
peroxisome proliferator-activated receptor gamma
chr13_+_110920830 8.24 ENSRNOT00000077014
ENSRNOT00000076362
potassium voltage-gated channel subfamily H member 1
chr19_+_12097632 8.15 ENSRNOT00000049452
carboxylesterase 5A
chr8_-_104995725 8.13 ENSRNOT00000037120
solute carrier family 25 member 36
chr3_-_11417546 8.08 ENSRNOT00000018776
lipocalin 2
chr8_-_82533689 8.01 ENSRNOT00000014124
tropomodulin 2
chr20_+_13498926 8.00 ENSRNOT00000070992
ENSRNOT00000045375
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chrX_-_123600890 7.98 ENSRNOT00000067942
septin 6
chr8_+_39997875 7.86 ENSRNOT00000050609
endothelial cell adhesion molecule
chr1_+_189870622 7.77 ENSRNOT00000075003
transmembrane protein 159
chr20_+_3351303 7.65 ENSRNOT00000080419
ENSRNOT00000001065
ENSRNOT00000086503
alpha tubulin acetyltransferase 1
chr1_+_100447998 7.63 ENSRNOT00000026259
leucine rich repeat containing 4B
chr7_-_62972084 7.56 ENSRNOT00000064251
methionine sulfoxide reductase B3
chr10_-_86688730 7.43 ENSRNOT00000055333
nuclear receptor subfamily 1, group D, member 1
chr4_-_129515435 7.23 ENSRNOT00000039353
EGF domain specific O-linked N-acetylglucosamine transferase
chr6_-_136145837 7.11 ENSRNOT00000015122
creatine kinase B
chr9_+_100830250 7.02 ENSRNOT00000024526
BOK, BCL2 family apoptosis regulator
chr9_+_82596355 6.97 ENSRNOT00000065076
SPEG complex locus
chr4_-_119568736 6.95 ENSRNOT00000041234
aprataxin and PNKP like factor
chr13_+_52147555 6.92 ENSRNOT00000084766
leiomodin 1
chr5_-_58198782 6.86 ENSRNOT00000023951
C-C motif chemokine ligand 21
chr15_+_62406873 6.76 ENSRNOT00000047572
olfactomedin 4
chr11_+_33909439 6.71 ENSRNOT00000002310
carbonyl reductase 3
chr16_-_62373253 6.69 ENSRNOT00000034325
testis expressed 15, meiosis and synapsis associated
chr14_+_86514214 6.60 ENSRNOT00000052002
zinc finger MIZ domain-containing protein 2
chr2_-_3124543 6.60 ENSRNOT00000036547
family with sequence similarity 81, member B
chr1_-_80783898 6.58 ENSRNOT00000045306
carcinoembryonic antigen-related cell adhesion molecule 16
chr15_+_87886783 6.56 ENSRNOT00000065710
SLAIN motif family, member 1
chr10_-_82887301 6.55 ENSRNOT00000035894
integrin subunit alpha 3
chr2_+_114386019 6.49 ENSRNOT00000082148

chr6_-_140572023 6.38 ENSRNOT00000072338

chr1_-_142500367 6.28 ENSRNOT00000015948
ENSRNOT00000089591
CREB regulated transcription coactivator 3
chr20_-_3401273 6.23 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
nurim (nuclear envelope membrane protein)
chr8_+_116336441 6.17 ENSRNOT00000090123
ENSRNOT00000021590
N-acetyltransferase 6
hyaluronoglucosaminidase 3
chr3_+_80556668 6.11 ENSRNOT00000079118
Rho GTPase activating protein 1
chr1_+_235166718 6.09 ENSRNOT00000020201
G protein subunit alpha 14
chr2_-_186245163 6.09 ENSRNOT00000089339
doublecortin-like kinase 2
chr7_+_120580743 6.05 ENSRNOT00000017181
MAF bZIP transcription factor F
chr5_-_6186329 6.01 ENSRNOT00000012610
sulfatase 1
chr10_-_13107771 6.01 ENSRNOT00000005879
FLYWCH-type zinc finger 1
chr4_+_85551502 6.00 ENSRNOT00000087191
ENSRNOT00000015692
aquaporin 1
chr4_+_147037179 5.99 ENSRNOT00000011292
synapsin II
chr1_-_190914610 5.99 ENSRNOT00000023189
cerebellar degeneration-related protein 2
chr17_-_86322144 5.98 ENSRNOT00000034474
hypothetical protein LOC681241
chr1_+_141550633 5.78 ENSRNOT00000020047
mesoderm posterior bHLH transcription factor 2
chr16_-_18645941 5.76 ENSRNOT00000079241
DPY30 domain containing 2
chr2_-_59084059 5.75 ENSRNOT00000086323
ENSRNOT00000088701
sperm flagellar 2
chr15_+_57221292 5.63 ENSRNOT00000014502
lymphocyte cytosolic protein 1
chr6_-_139102378 5.61 ENSRNOT00000086423

chr18_-_49937522 5.60 ENSRNOT00000033254
zinc finger protein 608
chr3_+_93920447 5.57 ENSRNOT00000012625
LIM domain only 2
chr7_+_129595192 5.51 ENSRNOT00000071151
zinc finger, DHHC-type containing 25
chr5_-_147691997 5.39 ENSRNOT00000011887
testis-specific serine kinase 3
chr6_-_138550576 5.33 ENSRNOT00000075284

chr1_+_256786124 5.32 ENSRNOT00000034563
free fatty acid receptor 4
chr4_+_142780987 5.31 ENSRNOT00000056570
glutamate metabotropic receptor 7
chr9_+_77320726 5.30 ENSRNOT00000068450
sperm associated antigen 16
chr5_-_62186372 5.29 ENSRNOT00000089789
coronin 2A
chr1_-_226353611 5.27 ENSRNOT00000037624
diacylglycerol lipase, alpha
chr7_+_77763512 5.26 ENSRNOT00000006411
brain and acute leukemia, cytoplasmic
chr9_-_98597359 5.21 ENSRNOT00000027506
period circadian clock 2
chr6_+_10348308 5.19 ENSRNOT00000034991
endothelial PAS domain protein 1
chr14_-_14390699 5.17 ENSRNOT00000046639
annexin A3
chr10_-_41408518 5.15 ENSRNOT00000018967
neuromedin U receptor 2
chr12_+_49665794 5.15 ENSRNOT00000082322
G protein-coupled receptor kinase 3
chr5_-_160158386 5.12 ENSRNOT00000089345
filamin binding LIM protein 1
chr1_-_261446570 5.05 ENSRNOT00000020182
secreted frizzled-related protein 5
chr1_+_196996581 5.01 ENSRNOT00000021690
interleukin 21 receptor
chrX_+_23414354 5.01 ENSRNOT00000031235
claudin 34A
chr1_+_88542035 4.98 ENSRNOT00000032973
zinc finger protein 420
chr8_-_64305330 4.96 ENSRNOT00000030199
transmembrane protein 202
chr1_-_72468738 4.94 ENSRNOT00000029136
zinc finger protein 628
chr15_-_24199341 4.93 ENSRNOT00000015553
DLG associated protein 5
chr17_-_77687456 4.89 ENSRNOT00000045765
ENSRNOT00000081645
FERM domain containing 4A
chr11_-_35697072 4.87 ENSRNOT00000039999
ERG, ETS transcription factor
chr1_-_101236065 4.82 ENSRNOT00000066834
CD37 molecule
chr3_-_3433148 4.80 ENSRNOT00000078020
calmodulin regulated spectrin-associated protein 1
chr2_-_202816562 4.78 ENSRNOT00000020401
family with sequence similarity 46, member C
chr1_-_242765807 4.77 ENSRNOT00000020763
phosphoglucomutase 5
chr1_+_85380088 4.67 ENSRNOT00000090129
zinc finger protein 36
chr2_+_80948658 4.67 ENSRNOT00000074689
dynein, axonemal, heavy chain 5
chr8_+_118744229 4.67 ENSRNOT00000028364
kinesin family member 9
chr1_-_116567189 4.66 ENSRNOT00000048996
protein BEX1-like
chr3_-_176465162 4.65 ENSRNOT00000048807
Sodium/potassium transporting ATPase interacting 4
chr4_-_14490446 4.61 ENSRNOT00000009132
semaphorin 3C
chr7_-_141624972 4.60 ENSRNOT00000078785

chr13_-_85443976 4.56 ENSRNOT00000005213
uridine-cytidine kinase 2
chr9_+_81880177 4.54 ENSRNOT00000022839
serine/threonine kinase 36
chr12_-_23727535 4.54 ENSRNOT00000085911
ENSRNOT00000001950
deltex E3 ubiquitin ligase 2
chr10_-_76039964 4.51 ENSRNOT00000003164
musashi RNA-binding protein 2
chr4_-_8255379 4.50 ENSRNOT00000076583
ENSRNOT00000076950
ENSRNOT00000076633
lysine methyltransferase 2E
chr6_-_44363915 4.49 ENSRNOT00000085925
inhibitor of DNA binding 2, HLH protein
chr5_-_171710312 4.46 ENSRNOT00000076044
ENSRNOT00000071280
ENSRNOT00000072059
ENSRNOT00000077015
PR/SET domain 16
chrX_+_70563570 4.43 ENSRNOT00000003772
glycerophosphodiester phosphodiesterase domain containing 2
chr3_-_80349145 4.40 ENSRNOT00000040633
similar to hypothetical protein MGC40841; similar to hypothetical protein MGC4707
chr2_-_80408672 4.34 ENSRNOT00000067638
family with sequence similarity 105, member A
chr15_+_3938075 4.33 ENSRNOT00000065644
calcium/calmodulin-dependent protein kinase II gamma
chr5_-_159293673 4.24 ENSRNOT00000009081
peptidyl arginine deiminase 4
chr10_-_90940118 4.23 ENSRNOT00000093143
elongation factor Tu GTP binding domain containing 2
chr4_+_98481520 4.21 ENSRNOT00000078381
ENSRNOT00000048493

chr5_-_63192025 4.19 ENSRNOT00000008913
ALG2, alpha-1,3/1,6-mannosyltransferase
chr20_+_7330250 4.16 ENSRNOT00000090993
LRRGT00097
chr1_-_178196294 4.08 ENSRNOT00000067170
BTB domain containing 10
chr4_-_27966398 4.06 ENSRNOT00000012597
cyclin-dependent kinase 6
chr1_-_219438779 4.03 ENSRNOT00000029237
TBC1 domain family, member 10C
chr16_+_19501193 3.96 ENSRNOT00000085328
cytochrome P450, family 4, subfamily f, polypeptide 18
chr4_-_56114254 3.94 ENSRNOT00000010673
leucine rich repeat containing 4
chr1_-_81946714 3.91 ENSRNOT00000027578
glutamate ionotropic receptor kainate type subunit 5
chr6_+_96479430 3.90 ENSRNOT00000006729
protein kinase C, eta
chr3_+_5624506 3.89 ENSRNOT00000036995
ADAMTS-like 2
chr19_+_39063998 3.85 ENSRNOT00000081116
hyaluronan synthase 3
chr13_+_100980574 3.83 ENSRNOT00000067005
ENSRNOT00000004649
calpain 8
chr3_+_122928964 3.82 ENSRNOT00000074724
rCG26795-like
chr1_-_72941869 3.80 ENSRNOT00000032306
EPS8-like 1
chr1_+_89008117 3.76 ENSRNOT00000028401
heat shock protein family B (small) member 6
chrX_-_2116656 3.74 ENSRNOT00000081913
retinitis pigmentosa 2 (X-linked recessive)
chrX_+_134742356 3.71 ENSRNOT00000005267
ENSRNOT00000082363
OCRL, inositol polyphosphate-5-phosphatase
chr7_+_145117951 3.70 ENSRNOT00000055272
phosphodiesterase 1B
chr3_+_153580861 3.69 ENSRNOT00000080516
ENSRNOT00000012739
SRC proto-oncogene, non-receptor tyrosine kinase
chrX_-_118615798 3.67 ENSRNOT00000045463
leucine rich repeats and calponin homology domain containing 2
chr1_+_198284473 3.65 ENSRNOT00000027022
double C2 domain alpha
chr18_-_25314047 3.62 ENSRNOT00000079778

chr10_+_53466870 3.60 ENSRNOT00000057503
phosphoinositide-interacting regulator of transient receptor potential channels
chr17_+_9109731 3.56 ENSRNOT00000016009
C-X-C motif chemokine ligand 14
chrX_+_106306795 3.51 ENSRNOT00000073661
G protein-coupled receptor associated sorting protein 1
chr1_-_265573117 3.51 ENSRNOT00000044195
ENSRNOT00000055915
Kv channel-interacting protein 2-like
chr10_-_47857326 3.50 ENSRNOT00000085703
ENSRNOT00000091963
epsin 2
chr6_-_21880003 3.49 ENSRNOT00000006505
tetratricopeptide repeat domain 27
chr6_-_3794489 3.47 ENSRNOT00000087891
ENSRNOT00000011000
ENSRNOT00000084499
THUMP domain containing 2
chr13_-_85443727 3.47 ENSRNOT00000090668
ENSRNOT00000076125
uridine-cytidine kinase 2
chr4_-_116278615 3.47 ENSRNOT00000020505
cytochrome P450, family 26, subfamily b, polypeptide 1
chr17_+_72240802 3.43 ENSRNOT00000025993
ENSRNOT00000090453
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr1_-_206394346 3.38 ENSRNOT00000038122
hypothetical LOC100302465
chr4_+_70572942 3.35 ENSRNOT00000051964

chr19_-_10358695 3.32 ENSRNOT00000019770
katanin regulatory subunit B1
chr20_+_7718282 3.24 ENSRNOT00000000593
signal peptide, CUB domain and EGF like domain containing 3
chr5_+_144031402 3.23 ENSRNOT00000011694
colony stimulating factor 3 receptor
chr2_+_29410579 3.22 ENSRNOT00000023180
zinc finger protein 366
chrX_-_2116483 3.21 ENSRNOT00000055077
retinitis pigmentosa 2 (X-linked recessive)
chr1_-_78212350 3.21 ENSRNOT00000071098
InaF-motif containing 1
chr6_-_6842758 3.20 ENSRNOT00000006094
potassium voltage-gated channel modifier subfamily G member 3
chr2_+_51672722 3.16 ENSRNOT00000016485
fibroblast growth factor 10
chr1_+_85437780 3.14 ENSRNOT00000093740
SPT5 homolog, DSIF elongation factor subunit
chr14_-_37871051 3.12 ENSRNOT00000003087
SLAIN motif family, member 2
chr16_+_9772688 3.12 ENSRNOT00000048001

chr9_+_16747662 3.10 ENSRNOT00000080815
cullin 9
chr16_+_17611115 3.05 ENSRNOT00000032309
SH2 domain containing 4B
chr1_-_241046249 3.05 ENSRNOT00000067796
ENSRNOT00000081866
structural maintenance of chromosomes 5

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
10.0 29.9 GO:0071387 cellular response to cortisol stimulus(GO:0071387)
8.5 25.5 GO:0035022 positive regulation of Rac protein signal transduction(GO:0035022)
7.7 30.9 GO:0042374 phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
7.5 22.5 GO:1902304 positive regulation of potassium ion export(GO:1902304)
7.0 21.0 GO:2001205 negative regulation of osteoclast development(GO:2001205)
5.5 16.4 GO:0010725 regulation of primitive erythrocyte differentiation(GO:0010725)
5.4 27.2 GO:0060014 granulosa cell differentiation(GO:0060014)
5.1 20.5 GO:2000860 positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)
5.0 20.0 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
2.8 8.4 GO:0032972 regulation of muscle filament sliding speed(GO:0032972)
2.7 8.2 GO:2000230 negative regulation of pancreatic stellate cell proliferation(GO:2000230)
2.7 8.1 GO:0015688 iron chelate transport(GO:0015688) siderophore transport(GO:0015891)
2.6 7.7 GO:0071929 alpha-tubulin acetylation(GO:0071929)
2.5 7.6 GO:0030091 protein repair(GO:0030091)
2.5 14.9 GO:0051365 cellular response to potassium ion starvation(GO:0051365)
2.5 7.4 GO:0060086 circadian temperature homeostasis(GO:0060086)
2.4 14.6 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
2.3 7.0 GO:1904700 granulosa cell apoptotic process(GO:1904700) regulation of granulosa cell apoptotic process(GO:1904708)
2.3 11.6 GO:2000173 insulin processing(GO:0030070) negative regulation of branching morphogenesis of a nerve(GO:2000173)
2.3 6.9 GO:0035759 mesangial cell-matrix adhesion(GO:0035759)
2.3 9.1 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
2.2 13.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
2.2 28.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
2.0 8.0 GO:0044211 CTP salvage(GO:0044211)
2.0 6.0 GO:0014846 esophagus smooth muscle contraction(GO:0014846)
2.0 6.0 GO:0072237 metanephric proximal tubule development(GO:0072237)
2.0 4.0 GO:0036101 leukotriene catabolic process(GO:0036100) leukotriene B4 catabolic process(GO:0036101) leukotriene B4 metabolic process(GO:0036102) icosanoid catabolic process(GO:1901523) fatty acid derivative catabolic process(GO:1901569)
1.9 14.9 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.8 5.3 GO:0051012 microtubule sliding(GO:0051012)
1.8 5.3 GO:0046340 diacylglycerol catabolic process(GO:0046340)
1.7 5.2 GO:0051933 amino acid neurotransmitter reuptake(GO:0051933) glutamate reuptake(GO:0051935)
1.7 6.9 GO:0051105 regulation of DNA ligation(GO:0051105) positive regulation of DNA ligation(GO:0051106)
1.7 5.1 GO:0032430 positive regulation of phospholipase A2 activity(GO:0032430)
1.7 5.1 GO:0043474 eye pigment metabolic process(GO:0042441) pigment metabolic process involved in developmental pigmentation(GO:0043324) pigment metabolic process involved in pigmentation(GO:0043474) rhodopsin metabolic process(GO:0046154)
1.7 5.1 GO:2000040 Wnt signaling pathway involved in digestive tract morphogenesis(GO:0044333) regulation of planar cell polarity pathway involved in axis elongation(GO:2000040) negative regulation of planar cell polarity pathway involved in axis elongation(GO:2000041)
1.7 18.2 GO:0046710 GDP metabolic process(GO:0046710)
1.5 4.5 GO:0001966 thigmotaxis(GO:0001966)
1.3 7.6 GO:0008078 mesodermal cell migration(GO:0008078)
1.3 2.5 GO:0007386 compartment pattern specification(GO:0007386)
1.3 20.1 GO:0050872 white fat cell differentiation(GO:0050872)
1.2 3.7 GO:0071393 cellular response to progesterone stimulus(GO:0071393)
1.2 6.1 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
1.2 4.8 GO:0030886 negative regulation of myeloid dendritic cell activation(GO:0030886)
1.2 10.7 GO:0060763 mammary duct terminal end bud growth(GO:0060763)
1.2 8.2 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.2 4.7 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
1.2 3.5 GO:1902809 cornification(GO:0070268) regulation of skeletal muscle fiber differentiation(GO:1902809)
1.2 4.6 GO:0003350 pulmonary myocardium development(GO:0003350)
1.1 4.5 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
1.1 9.0 GO:0060120 auditory receptor cell fate commitment(GO:0009912) inner ear receptor cell fate commitment(GO:0060120)
1.1 3.3 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
1.0 5.2 GO:0048625 myoblast fate commitment(GO:0048625) regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
1.0 11.1 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.0 13.0 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
1.0 3.9 GO:0036118 hyaluranon cable assembly(GO:0036118) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
0.9 13.3 GO:0002361 CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361)
0.8 4.2 GO:0018101 protein citrullination(GO:0018101) histone citrullination(GO:0036414)
0.8 4.9 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.8 7.1 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
0.8 6.3 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.8 3.9 GO:0031630 regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630)
0.8 7.0 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.8 6.2 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.8 82.3 GO:0001676 long-chain fatty acid metabolic process(GO:0001676)
0.7 2.2 GO:0030200 heparan sulfate proteoglycan catabolic process(GO:0030200)
0.7 7.6 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.7 6.8 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.6 4.8 GO:0019388 galactose catabolic process(GO:0019388)
0.6 14.5 GO:0044342 type B pancreatic cell proliferation(GO:0044342)
0.6 4.1 GO:0043696 dedifferentiation(GO:0043696) cell dedifferentiation(GO:0043697)
0.6 5.8 GO:0006348 chromatin silencing at telomere(GO:0006348)
0.6 4.0 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.6 1.7 GO:0090172 microtubule cytoskeleton organization involved in homologous chromosome segregation(GO:0090172)
0.5 3.1 GO:0034184 positive regulation of maintenance of mitotic sister chromatid cohesion(GO:0034184)
0.5 2.5 GO:0006685 sphingomyelin catabolic process(GO:0006685)
0.5 1.5 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.5 3.9 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.5 2.4 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.5 1.9 GO:0043987 histone H3-S10 phosphorylation(GO:0043987) histone H3-S28 phosphorylation(GO:0043988)
0.5 5.6 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.4 2.7 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
0.4 6.1 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.4 3.9 GO:0034351 negative regulation of glial cell apoptotic process(GO:0034351) positive regulation of keratinocyte differentiation(GO:0045618) positive regulation of B cell receptor signaling pathway(GO:0050861)
0.4 5.6 GO:0051764 actin crosslink formation(GO:0051764)
0.4 3.0 GO:2001135 regulation of endocytic recycling(GO:2001135)
0.4 4.2 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.4 3.7 GO:0036005 response to macrophage colony-stimulating factor(GO:0036005) cellular response to macrophage colony-stimulating factor stimulus(GO:0036006)
0.4 5.7 GO:0007288 sperm axoneme assembly(GO:0007288)
0.4 7.7 GO:0021860 pyramidal neuron development(GO:0021860)
0.4 4.4 GO:0090527 actin filament reorganization(GO:0090527)
0.4 2.8 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.4 4.3 GO:1901897 regulation of relaxation of cardiac muscle(GO:1901897)
0.4 5.1 GO:0033623 regulation of integrin activation(GO:0033623)
0.4 2.2 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 1.4 GO:0030240 skeletal muscle thin filament assembly(GO:0030240) detection of muscle stretch(GO:0035995)
0.3 3.1 GO:1900364 negative regulation of mRNA polyadenylation(GO:1900364)
0.3 4.7 GO:0021670 lateral ventricle development(GO:0021670)
0.3 4.0 GO:1904424 regulation of GTP binding(GO:1904424)
0.3 5.2 GO:0043312 neutrophil degranulation(GO:0043312)
0.3 1.8 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.3 3.5 GO:1901679 nucleotide transmembrane transport(GO:1901679)
0.3 4.5 GO:0042119 neutrophil activation(GO:0042119)
0.3 6.7 GO:0030539 male genitalia development(GO:0030539)
0.3 3.9 GO:0097119 postsynaptic density protein 95 clustering(GO:0097119)
0.3 1.8 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.2 8.4 GO:1902042 negative regulation of extrinsic apoptotic signaling pathway via death domain receptors(GO:1902042)
0.2 1.9 GO:0034242 negative regulation of syncytium formation by plasma membrane fusion(GO:0034242)
0.2 1.7 GO:0018095 protein polyglutamylation(GO:0018095)
0.2 1.1 GO:0035627 ceramide transport(GO:0035627)
0.2 1.6 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.2 2.9 GO:0007097 nuclear migration(GO:0007097)
0.2 3.2 GO:0033147 negative regulation of intracellular estrogen receptor signaling pathway(GO:0033147)
0.2 6.1 GO:0045604 regulation of epidermal cell differentiation(GO:0045604)
0.2 2.1 GO:0042270 protection from natural killer cell mediated cytotoxicity(GO:0042270)
0.2 1.6 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.2 10.1 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.2 33.5 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.2 0.7 GO:0038110 interleukin-2-mediated signaling pathway(GO:0038110)
0.2 4.9 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.2 0.7 GO:0001555 oocyte growth(GO:0001555)
0.2 0.7 GO:0097117 guanylate kinase-associated protein clustering(GO:0097117)
0.2 1.6 GO:0060347 heart trabecula formation(GO:0060347)
0.2 7.6 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.2 3.0 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.1 0.6 GO:0070093 negative regulation of glucagon secretion(GO:0070093)
0.1 3.1 GO:0007020 microtubule nucleation(GO:0007020)
0.1 3.7 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.1 1.2 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 1.1 GO:0070933 histone H4 deacetylation(GO:0070933)
0.1 0.8 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.1 3.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.1 7.2 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 3.6 GO:0048266 behavioral response to pain(GO:0048266)
0.1 0.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.1 5.3 GO:0050912 detection of chemical stimulus involved in sensory perception of taste(GO:0050912)
0.1 3.2 GO:0097186 amelogenesis(GO:0097186)
0.1 1.6 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
0.1 4.7 GO:0022617 extracellular matrix disassembly(GO:0022617)
0.1 7.6 GO:0055013 cardiac muscle cell development(GO:0055013)
0.1 8.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 3.4 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 1.2 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.1 1.6 GO:1900151 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.1 1.2 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 3.5 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.1 0.4 GO:0019046 viral latency(GO:0019042) release from viral latency(GO:0019046)
0.1 1.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0071625 vocalization behavior(GO:0071625)
0.1 0.9 GO:0015825 L-serine transport(GO:0015825)
0.1 0.7 GO:0035563 positive regulation of chromatin binding(GO:0035563)
0.1 1.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.1 3.6 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.1 4.2 GO:0042220 response to cocaine(GO:0042220)
0.1 2.1 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.6 GO:0031065 positive regulation of histone deacetylation(GO:0031065)
0.1 3.8 GO:0061077 chaperone-mediated protein folding(GO:0061077)
0.1 0.8 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.1 2.3 GO:0071158 positive regulation of cell cycle arrest(GO:0071158)
0.1 0.5 GO:0042487 regulation of odontogenesis of dentin-containing tooth(GO:0042487)
0.1 0.9 GO:0010996 response to auditory stimulus(GO:0010996)
0.1 1.8 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.1 1.0 GO:0002717 positive regulation of natural killer cell mediated immunity(GO:0002717) positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.0 2.2 GO:0060612 adipose tissue development(GO:0060612)
0.0 0.6 GO:0003334 keratinocyte development(GO:0003334)
0.0 7.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 2.9 GO:0051865 protein autoubiquitination(GO:0051865)
0.0 0.1 GO:0060385 axonogenesis involved in innervation(GO:0060385)
0.0 8.0 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 4.4 GO:0008360 regulation of cell shape(GO:0008360)
0.0 2.5 GO:0032091 negative regulation of protein binding(GO:0032091)
0.0 0.5 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.0 1.3 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.0 4.5 GO:0048864 stem cell development(GO:0048864)
0.0 1.2 GO:0046928 regulation of neurotransmitter secretion(GO:0046928)
0.0 3.1 GO:0007088 regulation of mitotic nuclear division(GO:0007088)
0.0 2.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.2 GO:0099643 neurotransmitter secretion(GO:0007269) signal release from synapse(GO:0099643)
0.0 1.0 GO:0006801 superoxide metabolic process(GO:0006801)
0.0 0.2 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 3.6 GO:0045786 negative regulation of cell cycle(GO:0045786)
0.0 0.2 GO:0003170 heart valve development(GO:0003170)
0.0 2.4 GO:0006470 protein dephosphorylation(GO:0006470)
0.0 0.7 GO:0002181 cytoplasmic translation(GO:0002181)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
6.6 19.9 GO:0032173 septin collar(GO:0032173)
5.6 16.7 GO:0034667 integrin alpha3-beta1 complex(GO:0034667)
3.3 20.0 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
2.1 8.4 GO:1990584 cardiac Troponin complex(GO:1990584)
1.9 7.7 GO:0097427 microtubule bundle(GO:0097427)
1.7 18.2 GO:0002177 manchette(GO:0002177)
1.6 27.2 GO:0030061 mitochondrial crista(GO:0030061)
1.5 6.0 GO:0020005 symbiont-containing vacuole membrane(GO:0020005)
1.3 9.1 GO:0097524 sperm plasma membrane(GO:0097524)
1.3 3.9 GO:0036117 hyaluranon cable(GO:0036117)
1.2 19.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
1.1 5.3 GO:1990716 axonemal central apparatus(GO:1990716)
1.0 13.7 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
1.0 7.6 GO:0044300 cerebellar mossy fiber(GO:0044300)
0.9 25.5 GO:0043194 axon initial segment(GO:0043194)
0.8 22.5 GO:0042629 mast cell granule(GO:0042629)
0.8 4.7 GO:0036157 outer dynein arm(GO:0036157)
0.8 7.0 GO:1990075 periciliary membrane compartment(GO:1990075)
0.8 6.1 GO:0097443 sorting endosome(GO:0097443)
0.7 11.9 GO:0042581 specific granule(GO:0042581)
0.7 11.6 GO:0031045 dense core granule(GO:0031045)
0.7 3.9 GO:0032983 kainate selective glutamate receptor complex(GO:0032983)
0.6 3.1 GO:0035061 interchromatin granule(GO:0035061)
0.6 14.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.6 4.7 GO:0070578 RISC-loading complex(GO:0070578)
0.5 6.6 GO:0032426 stereocilium tip(GO:0032426)
0.5 2.7 GO:0097209 epidermal lamellar body(GO:0097209)
0.4 1.8 GO:0097513 myosin II filament(GO:0097513)
0.4 3.4 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.4 2.9 GO:0005869 dynactin complex(GO:0005869)
0.4 4.0 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.3 6.2 GO:0048188 Set1C/COMPASS complex(GO:0048188)
0.3 4.7 GO:0031616 spindle pole centrosome(GO:0031616)
0.3 8.7 GO:0005640 nuclear outer membrane(GO:0005640)
0.3 4.0 GO:0031527 filopodium membrane(GO:0031527)
0.3 39.3 GO:0005884 actin filament(GO:0005884)
0.3 5.3 GO:0032279 asymmetric synapse(GO:0032279)
0.3 5.3 GO:0043196 varicosity(GO:0043196)
0.3 14.5 GO:0005637 nuclear inner membrane(GO:0005637)
0.3 5.1 GO:0044292 dendrite terminus(GO:0044292)
0.3 4.8 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.2 3.5 GO:0030128 clathrin coat of endocytic vesicle(GO:0030128)
0.2 6.4 GO:0035371 microtubule plus-end(GO:0035371)
0.2 31.1 GO:0005923 bicellular tight junction(GO:0005923)
0.2 2.7 GO:0030130 clathrin coat of trans-Golgi network vesicle(GO:0030130)
0.2 5.1 GO:0045120 pronucleus(GO:0045120)
0.2 6.9 GO:0035861 site of double-strand break(GO:0035861)
0.2 0.7 GO:0032044 DSIF complex(GO:0032044)
0.2 4.7 GO:0002102 podosome(GO:0002102)
0.2 11.8 GO:0005581 collagen trimer(GO:0005581)
0.2 0.8 GO:0043293 apoptosome(GO:0043293)
0.1 5.0 GO:0001772 immunological synapse(GO:0001772)
0.1 1.2 GO:0031313 extrinsic component of endosome membrane(GO:0031313)
0.1 4.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.1 10.8 GO:0099501 synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501)
0.1 8.5 GO:0005811 lipid particle(GO:0005811)
0.1 3.7 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.1 9.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 14.4 GO:0001650 fibrillar center(GO:0001650)
0.1 4.2 GO:0015030 Cajal body(GO:0015030)
0.1 0.7 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 0.7 GO:0070937 CRD-mediated mRNA stability complex(GO:0070937)
0.1 4.5 GO:0005844 polysome(GO:0005844)
0.1 2.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.1 0.2 GO:0070557 PCNA-p21 complex(GO:0070557)
0.1 28.8 GO:0005667 transcription factor complex(GO:0005667)
0.1 1.3 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 12.7 GO:0030426 growth cone(GO:0030426)
0.1 0.9 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.1 0.5 GO:0005964 phosphorylase kinase complex(GO:0005964)
0.1 9.3 GO:0043197 dendritic spine(GO:0043197)
0.1 1.6 GO:0097546 ciliary base(GO:0097546)
0.1 2.3 GO:0005834 heterotrimeric G-protein complex(GO:0005834)
0.1 1.3 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 6.4 GO:0001726 ruffle(GO:0001726)
0.1 4.5 GO:0005902 microvillus(GO:0005902)
0.1 1.6 GO:0031430 M band(GO:0031430)
0.1 8.6 GO:0043209 myelin sheath(GO:0043209)
0.1 4.3 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.1 0.3 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 2.3 GO:0097517 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)
0.0 8.7 GO:0031965 nuclear membrane(GO:0031965)
0.0 2.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 2.7 GO:0016605 PML body(GO:0016605)
0.0 10.1 GO:0030425 dendrite(GO:0030425)
0.0 1.1 GO:0044452 nucleolar part(GO:0044452)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.8 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.0 5.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 1.3 GO:0030139 endocytic vesicle(GO:0030139)
0.0 0.1 GO:0044530 supraspliceosomal complex(GO:0044530)
0.0 0.1 GO:1902562 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.0 0.6 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 2.8 GO:0010008 endosome membrane(GO:0010008)
0.0 4.5 GO:0000785 chromatin(GO:0000785)
0.0 0.6 GO:0030018 Z disc(GO:0030018)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
8.5 85.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
6.2 30.9 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
5.0 14.9 GO:0047783 steroid 11-beta-monooxygenase activity(GO:0004507) corticosterone 18-monooxygenase activity(GO:0047783)
4.9 14.6 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
4.5 27.2 GO:0016713 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
3.6 10.7 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
3.4 13.4 GO:0042610 CD8 receptor binding(GO:0042610)
3.2 13.0 GO:0004487 methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487)
3.1 18.8 GO:0005499 vitamin D binding(GO:0005499)
2.4 22.0 GO:0019871 sodium channel inhibitor activity(GO:0019871)
2.2 20.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
2.1 8.4 GO:0030172 troponin C binding(GO:0030172)
2.1 6.2 GO:0033906 hyaluronoglucuronidase activity(GO:0033906)
2.0 4.0 GO:0050051 leukotriene-B4 20-monooxygenase activity(GO:0050051) tocopherol omega-hydroxylase activity(GO:0052870) alpha-tocopherol omega-hydroxylase activity(GO:0052871)
1.9 7.6 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
1.8 18.2 GO:0004385 guanylate kinase activity(GO:0004385)
1.8 5.3 GO:0070905 serine binding(GO:0070905)
1.6 8.0 GO:0004849 uridine kinase activity(GO:0004849)
1.5 6.0 GO:0008449 N-acetylglucosamine-6-sulfatase activity(GO:0008449)
1.4 7.2 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
1.4 16.8 GO:0050897 cobalt ion binding(GO:0050897)
1.4 4.2 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.4 9.6 GO:0004111 creatine kinase activity(GO:0004111)
1.4 13.7 GO:0019957 C-C chemokine binding(GO:0019957)
1.2 6.0 GO:0015168 polyol transmembrane transporter activity(GO:0015166) glycerol transmembrane transporter activity(GO:0015168)
1.2 8.2 GO:0050692 DBD domain binding(GO:0050692)
1.2 8.2 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.2 3.5 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
1.1 8.0 GO:1990226 histone methyltransferase binding(GO:1990226)
1.1 7.7 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
1.1 3.2 GO:0051916 granulocyte colony-stimulating factor binding(GO:0051916)
1.1 4.2 GO:0034618 arginine binding(GO:0034618)
1.0 5.2 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
1.0 22.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.0 14.9 GO:0005523 tropomyosin binding(GO:0005523)
1.0 3.9 GO:0004699 calcium-independent protein kinase C activity(GO:0004699)
1.0 4.8 GO:0004614 phosphoglucomutase activity(GO:0004614)
0.9 3.7 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.9 5.1 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
0.8 2.4 GO:0004096 catalase activity(GO:0004096)
0.8 8.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.8 16.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.8 3.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.8 2.3 GO:0001641 group II metabotropic glutamate receptor activity(GO:0001641)
0.7 4.4 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.6 3.2 GO:0005111 type 2 fibroblast growth factor receptor binding(GO:0005111)
0.6 6.3 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.6 13.3 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.6 9.3 GO:0051400 BH domain binding(GO:0051400)
0.6 3.9 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.5 3.8 GO:0042608 T cell receptor binding(GO:0042608)
0.5 3.7 GO:0071253 connexin binding(GO:0071253)
0.5 5.1 GO:0097157 pre-mRNA intronic binding(GO:0097157)
0.5 3.0 GO:0017040 ceramidase activity(GO:0017040)
0.5 16.7 GO:0043236 laminin binding(GO:0043236)
0.5 11.5 GO:0005112 Notch binding(GO:0005112)
0.5 12.5 GO:0043014 alpha-tubulin binding(GO:0043014)
0.5 14.0 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.5 3.7 GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439)
0.5 6.9 GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906)
0.5 2.7 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
0.4 1.7 GO:0070739 protein-glutamic acid ligase activity(GO:0070739)
0.4 7.4 GO:0001222 transcription corepressor binding(GO:0001222)
0.4 4.6 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 2.5 GO:0004767 sphingomyelin phosphodiesterase activity(GO:0004767)
0.4 1.1 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
0.3 8.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 22.1 GO:0005518 collagen binding(GO:0005518)
0.3 2.2 GO:0045545 syndecan binding(GO:0045545)
0.3 2.5 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 12.5 GO:0005504 fatty acid binding(GO:0005504)
0.3 1.4 GO:0051373 FATZ binding(GO:0051373)
0.3 9.5 GO:0008009 chemokine activity(GO:0008009)
0.2 6.1 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.2 0.7 GO:0004911 interleukin-2 receptor activity(GO:0004911)
0.2 3.3 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.2 0.7 GO:0034046 poly(G) binding(GO:0034046)
0.2 5.8 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 2.1 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.2 20.2 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.2 4.5 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 6.3 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.2 5.1 GO:0042923 neuropeptide binding(GO:0042923)
0.2 5.3 GO:0008527 taste receptor activity(GO:0008527)
0.2 3.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.2 3.8 GO:0005212 structural constituent of eye lens(GO:0005212)
0.2 1.0 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.2 5.6 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 3.2 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.2 3.8 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 4.1 GO:0030332 cyclin binding(GO:0030332)
0.1 4.9 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 1.0 GO:0004467 long-chain fatty acid-CoA ligase activity(GO:0004467)
0.1 1.8 GO:0030898 actin-dependent ATPase activity(GO:0030898)
0.1 2.5 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.1 0.7 GO:0046624 sphingolipid transporter activity(GO:0046624)
0.1 1.7 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 2.4 GO:0015215 nucleotide transmembrane transporter activity(GO:0015215)
0.1 5.3 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 4.8 GO:0030507 spectrin binding(GO:0030507)
0.1 0.7 GO:0030160 GKAP/Homer scaffold activity(GO:0030160)
0.1 7.0 GO:0033613 activating transcription factor binding(GO:0033613)
0.1 6.0 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 3.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 7.6 GO:0003777 microtubule motor activity(GO:0003777)
0.1 1.3 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 3.5 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.7 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.7 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 0.9 GO:0015194 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 7.8 GO:0044325 ion channel binding(GO:0044325)
0.1 2.6 GO:0008408 3'-5' exonuclease activity(GO:0008408)
0.1 11.1 GO:0051015 actin filament binding(GO:0051015)
0.1 3.2 GO:0030331 estrogen receptor binding(GO:0030331)
0.1 3.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.1 1.8 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 5.3 GO:0005178 integrin binding(GO:0005178)
0.1 1.9 GO:0050699 WW domain binding(GO:0050699)
0.1 4.9 GO:0004896 cytokine receptor activity(GO:0004896)
0.1 1.3 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 2.1 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.0 2.6 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.0 4.9 GO:0030674 protein binding, bridging(GO:0030674)
0.0 1.6 GO:0019894 kinesin binding(GO:0019894)
0.0 13.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.9 GO:0001671 ATPase activator activity(GO:0001671)
0.0 11.8 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.5 GO:0051219 phosphoprotein binding(GO:0051219)
0.0 8.5 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.5 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 1.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 0.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 2.4 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.0 1.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 0.6 GO:0004536 deoxyribonuclease activity(GO:0004536)
0.0 0.8 GO:0031072 heat shock protein binding(GO:0031072)
0.0 0.9 GO:0036459 thiol-dependent ubiquitinyl hydrolase activity(GO:0036459)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 29.9 ST WNT CA2 CYCLIC GMP PATHWAY Wnt/Ca2+/cyclic GMP signaling.
0.8 17.1 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.7 12.6 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.6 49.7 PID AP1 PATHWAY AP-1 transcription factor network
0.5 15.1 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.4 6.1 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.4 6.9 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.3 12.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.2 8.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 12.2 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 5.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 4.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.2 30.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 2.3 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.2 5.2 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 3.9 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.2 14.1 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.2 4.1 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 9.2 PID E2F PATHWAY E2F transcription factor network
0.1 4.9 PID AURORA A PATHWAY Aurora A signaling
0.1 2.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.4 PID ARF6 PATHWAY Arf6 signaling events
0.1 1.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.1 34.9 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 4.5 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 1.6 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 0.7 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.1 12.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.0 ST GA12 PATHWAY G alpha 12 Pathway
0.0 1.8 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.6 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.7 PID NOTCH PATHWAY Notch signaling pathway
0.0 1.5 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.0 0.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.7 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.2 72.1 REACTOME ENDOGENOUS STEROLS Genes involved in Endogenous sterols
2.3 9.1 REACTOME BETA DEFENSINS Genes involved in Beta defensins
2.3 78.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
1.4 25.5 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
1.2 17.1 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
1.0 20.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.8 12.5 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.8 22.5 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.8 9.0 REACTOME SIGNALING BY NOTCH2 Genes involved in Signaling by NOTCH2
0.7 2.2 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.6 21.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.6 10.0 REACTOME ACYL CHAIN REMODELLING OF PS Genes involved in Acyl chain remodelling of PS
0.6 6.1 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.6 15.9 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.6 5.2 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.6 7.4 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.6 11.1 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.5 11.6 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 6.0 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.5 7.2 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.3 16.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.3 7.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.3 5.1 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.3 9.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 5.2 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
0.3 16.8 REACTOME MUSCLE CONTRACTION Genes involved in Muscle contraction
0.3 4.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.3 8.0 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.2 4.0 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 29.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.2 4.7 REACTOME DESTABILIZATION OF MRNA BY TRISTETRAPROLIN TTP Genes involved in Destabilization of mRNA by Tristetraprolin (TTP)
0.2 3.5 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.2 11.5 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.7 REACTOME DAG AND IP3 SIGNALING Genes involved in DAG and IP3 signaling
0.2 3.4 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.2 2.8 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.2 3.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.2 3.2 REACTOME FGFR1 LIGAND BINDING AND ACTIVATION Genes involved in FGFR1 ligand binding and activation
0.2 4.2 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 2.7 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.1 6.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 4.2 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
0.1 3.0 REACTOME N GLYCAN ANTENNAE ELONGATION IN THE MEDIAL TRANS GOLGI Genes involved in N-glycan antennae elongation in the medial/trans-Golgi
0.1 4.3 REACTOME G1 PHASE Genes involved in G1 Phase
0.1 2.3 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 8.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 3.1 REACTOME MRNA CAPPING Genes involved in mRNA Capping
0.1 1.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.1 1.0 REACTOME CD28 DEPENDENT VAV1 PATHWAY Genes involved in CD28 dependent Vav1 pathway
0.1 3.0 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.1 1.9 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 1.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.1 1.6 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 5.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.0 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 2.9 REACTOME MHC CLASS II ANTIGEN PRESENTATION Genes involved in MHC class II antigen presentation
0.1 1.0 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.0 1.3 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
0.0 1.6 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 1.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.8 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.0 0.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.0 1.8 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors