ISMARA results: Tbx5

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx5

Z-value: 0.97

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Transcription factors associated with Tbx5

Gene Symbol	Gene ID	Gene Info
Tbx5 NCBI RGD Ensembl	ENSRNOG00000001399	T-box 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbx5	rn6_v1_chr12_+_42097626_42097626	0.39	2.9e-13	Click!

Activity profile of Tbx5 motif

Sorted Z-values of Tbx5 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr18_+_53609214 Show fit	85.37	ENSRNOT00000077443	Slc27a6 NCBI RGD Ensembl Show fit	solute carrier family 27 member 6
chr6_-_2311781 Show fit	29.87	ENSRNOT00000084171	Cyp1b1 NCBI RGD Ensembl Show fit	cytochrome P450, family 1, subfamily b, polypeptide 1
chr8_+_62779875 Show fit	27.24	ENSRNOT00000010831	Cyp11a1 NCBI RGD Ensembl Show fit	cytochrome P450, family 11, subfamily a, polypeptide 1
chr2_+_230901126 Show fit	25.54	ENSRNOT00000016026 ENSRNOT00000015564 ENSRNOT00000068198	Camk2d NCBI RGD Ensembl Show fit	calcium/calmodulin-dependent protein kinase II delta
chr10_-_91661558 Show fit	24.60	ENSRNOT00000043156	AABR07030521.1 NCBI RGD Ensembl Show fit
chr5_+_164808323 Show fit	22.48	ENSRNOT00000011005	Nppa NCBI RGD Ensembl Show fit	natriuretic peptide A
chr8_-_107952530 Show fit	21.00	ENSRNOT00000052043	Cldn18 NCBI RGD Ensembl Show fit	claudin 18
chr10_+_107455845 Show fit	20.51	ENSRNOT00000004373	C1qtnf1 NCBI RGD Ensembl Show fit	C1q and tumor necrosis factor related protein 1
chr1_+_156552328 Show fit	19.38	ENSRNOT00000055401	Dlg2 NCBI RGD Ensembl Show fit	discs large MAGUK scaffold protein 2
chrX_+_33443186 Show fit	18.75	ENSRNOT00000005622	S100g NCBI RGD Ensembl Show fit	S100 calcium binding protein G

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	82.3	GO:0001676	long-chain fatty acid metabolic process(GO:0001676)
0.2	33.5	GO:0002244	hematopoietic progenitor cell differentiation(GO:0002244)
7.7	30.9	GO:0042374	phylloquinone metabolic process(GO:0042374) phylloquinone catabolic process(GO:0042376) quinone catabolic process(GO:1901662)
10.0	29.9	GO:0071387	cellular response to cortisol stimulus(GO:0071387)
2.2	28.9	GO:0007342	fusion of sperm to egg plasma membrane(GO:0007342)
5.4	27.2	GO:0060014	granulosa cell differentiation(GO:0060014)
8.5	25.5	GO:0035022	positive regulation of Rac protein signal transduction(GO:0035022)
7.5	22.5	GO:1902304	positive regulation of potassium ion export(GO:1902304)
7.0	21.0	GO:2001205	negative regulation of osteoclast development(GO:2001205)
5.1	20.5	GO:2000860	positive regulation of mineralocorticoid secretion(GO:2000857) positive regulation of aldosterone secretion(GO:2000860)

Showing 1 to 10 of 183 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	39.3	GO:0005884	actin filament(GO:0005884)
0.2	31.1	GO:0005923	bicellular tight junction(GO:0005923)
0.1	28.8	GO:0005667	transcription factor complex(GO:0005667)
1.6	27.2	GO:0030061	mitochondrial crista(GO:0030061)
0.9	25.5	GO:0043194	axon initial segment(GO:0043194)
0.8	22.5	GO:0042629	mast cell granule(GO:0042629)
3.3	20.0	GO:0042567	insulin-like growth factor ternary complex(GO:0042567)
6.6	19.9	GO:0032173	septin collar(GO:0032173)
1.2	19.4	GO:0044224	juxtaparanode region of axon(GO:0044224)
1.7	18.2	GO:0002177	manchette(GO:0002177)

Showing 1 to 10 of 96 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.5	85.4	GO:0031957	very long-chain fatty acid-CoA ligase activity(GO:0031957)
6.2	30.9	GO:0004090	carbonyl reductase (NADPH) activity(GO:0004090)
4.5	27.2	GO:0016713	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen(GO:0016713)
1.0	22.5	GO:0051428	peptide hormone receptor binding(GO:0051428)
0.3	22.1	GO:0005518	collagen binding(GO:0005518)
2.4	22.0	GO:0019871	sodium channel inhibitor activity(GO:0019871)
0.2	20.2	GO:0004860	protein kinase inhibitor activity(GO:0004860)
2.2	20.0	GO:0031995	insulin-like growth factor II binding(GO:0031995)
3.1	18.8	GO:0005499	vitamin D binding(GO:0005499)
1.8	18.2	GO:0004385	guanylate kinase activity(GO:0004385)

Showing 1 to 10 of 138 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	49.7	PID AP1 PATHWAY	AP-1 transcription factor network
0.1	34.9	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
0.2	30.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
1.1	29.9	ST WNT CA2 CYCLIC GMP PATHWAY	Wnt/Ca2+/cyclic GMP signaling.
0.8	17.1	PID SYNDECAN 3 PATHWAY	Syndecan-3-mediated signaling events
0.5	15.1	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
0.2	14.1	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
0.1	12.7	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.7	12.6	PID CIRCADIAN PATHWAY	Circadian rhythm pathway
0.3	12.3	PID ARF6 TRAFFICKING PATHWAY	Arf6 trafficking events

Showing 1 to 10 of 35 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.3	78.8	REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES	Genes involved in Transport of vitamins, nucleosides, and related molecules
4.2	72.1	REACTOME ENDOGENOUS STEROLS	Genes involved in Endogenous sterols
0.2	29.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production
1.4	25.5	REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII	Genes involved in CREB phosphorylation through the activation of CaMKII
0.8	22.5	REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION	Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.6	21.0	REACTOME TIGHT JUNCTION INTERACTIONS	Genes involved in Tight junction interactions
1.0	20.0	REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS	Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
1.2	17.1	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.3	16.8	REACTOME MUSCLE CONTRACTION	Genes involved in Muscle contraction
0.3	16.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines

Showing 1 to 10 of 63 entries

Results for Tbx5

Z-value: 0.97

Motif logo

Transcription factors associated with Tbx5

Activity-expression correlation:

Activity profile of Tbx5 motif

Sorted Z-values of Tbx5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx5

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: