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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx21

Z-value: 1.37

Motif logo

Transcription factors associated with Tbx21

Gene Symbol Gene ID Gene Info
ENSRNOG00000009427 T-box 21

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx21rn6_v1_chr10_-_85049331_850493310.371.0e-11Click!

Activity profile of Tbx21 motif

Sorted Z-values of Tbx21 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_138239306 39.24 ENSRNOT00000039305
erythroblast membrane-associated protein
chr13_+_82369493 38.13 ENSRNOT00000003733
selectin L
chr6_-_138550576 37.49 ENSRNOT00000075284

chr6_-_138744480 35.49 ENSRNOT00000089387

chr14_+_38030189 33.09 ENSRNOT00000035623
TXK tyrosine kinase
chr6_-_138909105 26.90 ENSRNOT00000087855

chr7_+_140758615 26.84 ENSRNOT00000089448
trophinin associated protein
chr1_+_199495298 26.72 ENSRNOT00000086003
ENSRNOT00000026748
integrin subunit alpha D
chr8_-_36760742 24.76 ENSRNOT00000017307
DEAD-box helicase 25
chr6_-_28967902 24.64 ENSRNOT00000032664
major facilitator superfamily domain containing 2B
chr6_-_138772894 24.20 ENSRNOT00000080779

chr3_+_17180411 24.20 ENSRNOT00000058260

chr1_-_198476476 24.07 ENSRNOT00000027525
kinesin family member 22
chr6_-_138772736 23.96 ENSRNOT00000071492

chr17_-_44841382 23.71 ENSRNOT00000080119
histone cluster 1, H2ak
chr5_+_152680407 23.60 ENSRNOT00000076864
stathmin 1
chr2_+_87418517 22.39 ENSRNOT00000048046
tyrosine-protein phosphatase non-receptor type substrate 1-like
chr19_+_52217984 21.76 ENSRNOT00000079580
dynein, axonemal, assembly factor 1
chr10_+_72486152 21.40 ENSRNOT00000004193
similar to Chromodomain-helicase-DNA-binding protein 1 (CHD-1)
chrX_+_138046494 21.32 ENSRNOT00000010596
serine/threonine kinase 26
chr1_-_20417637 21.24 ENSRNOT00000036049
similar to High mobility group protein 2 (HMG-2)
chr18_+_86307646 21.02 ENSRNOT00000091778
CD226 molecule
chr20_-_3401273 21.01 ENSRNOT00000089257
ENSRNOT00000078451
ENSRNOT00000001085
nurim (nuclear envelope membrane protein)
chr15_+_28074953 20.47 ENSRNOT00000086427
ribonuclease pancreatic beta-type
chr20_-_11815647 19.99 ENSRNOT00000001639
integrin subunit beta 2
chr10_+_105498728 19.57 ENSRNOT00000032163
sphingosine kinase 1
chr6_+_132551394 19.35 ENSRNOT00000019583
Enah/Vasp-like
chr8_-_62410338 19.11 ENSRNOT00000026358
c-src tyrosine kinase
chr6_+_139405966 19.04 ENSRNOT00000088974

chr10_-_110232843 18.84 ENSRNOT00000054934
Cd7 molecule
chr5_+_122508388 18.53 ENSRNOT00000038410
Tctex1 domain containing 1
chr6_+_139523337 18.26 ENSRNOT00000090711

chr6_+_139523495 17.85 ENSRNOT00000075467

chr6_-_138852571 17.74 ENSRNOT00000081803

chr1_-_100234040 17.71 ENSRNOT00000079199
acid phosphatase, testicular
chr10_+_91254058 17.41 ENSRNOT00000087218
ENSRNOT00000065373
formin-like 1
chr10_-_104054805 17.33 ENSRNOT00000004853
5', 3'-nucleotidase, cytosolic
chr12_+_14021727 16.69 ENSRNOT00000060608
monocyte to macrophage differentiation-associated 2
chr7_+_119820537 16.53 ENSRNOT00000077256
ENSRNOT00000056221
cytohesin 4
chr6_-_138685656 16.28 ENSRNOT00000041706

chr17_+_44520537 15.71 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr1_+_63734135 15.57 ENSRNOT00000084439
neutrophil immunoglobulin-like receptor-1
chr5_-_122642202 15.33 ENSRNOT00000046691
WD repeat domain 78
chr15_+_30270740 15.22 ENSRNOT00000070991

chr1_+_201672528 15.17 ENSRNOT00000093490
deleted in malignant brain tumors 1
chr4_-_164406146 14.90 ENSRNOT00000090110
killer cell lectin-like receptor subfamily A, member 22
chr6_-_138507294 14.81 ENSRNOT00000078516

chr2_+_209661244 14.72 ENSRNOT00000091973

chr2_-_200513564 14.45 ENSRNOT00000056173
phosphoglycerate dehydrogenase
chr3_-_26056818 14.35 ENSRNOT00000044209
LDL receptor related protein 1B
chr11_-_69355854 14.09 ENSRNOT00000002975
rhophilin associated tail protein 1
chr18_+_62850588 14.05 ENSRNOT00000025172
G protein subunit alpha L
chrX_+_156274800 13.99 ENSRNOT00000080887
glucose-6-phosphate dehydrogenase
chr12_+_16913312 13.66 ENSRNOT00000001718
transmembrane protein 184A
chr5_-_151459037 13.45 ENSRNOT00000064472
ENSRNOT00000087836
synaptotagmin-like 1
chr5_+_69833225 13.34 ENSRNOT00000013759
nipsnap homolog 3B
chr10_+_57239993 13.24 ENSRNOT00000067919
hypothetical protein LOC687707
chr18_-_77322690 13.04 ENSRNOT00000058382
nuclear factor of activated T-cells 1
chr8_+_28454962 12.96 ENSRNOT00000051573
spermatogenesis associated 19
chr2_+_30664217 12.17 ENSRNOT00000076786
adenylate kinase 6
chr16_-_31301880 12.12 ENSRNOT00000084847
ENSRNOT00000083943

chr14_-_83219071 12.09 ENSRNOT00000085788
DEP domain containing 5
chr6_-_139660666 12.09 ENSRNOT00000086098

chr9_+_14951047 11.99 ENSRNOT00000074267
uncharacterized LOC100911489
chr5_+_152681101 11.98 ENSRNOT00000076052
ENSRNOT00000022574
stathmin 1
chr1_+_212714179 11.96 ENSRNOT00000054880
ENSRNOT00000025680
olfactory receptor 292
chr17_-_44520240 11.90 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr1_-_189182306 11.73 ENSRNOT00000021249
glycoprotein 2
chr3_-_113405829 11.69 ENSRNOT00000036823
elongation factor for RNA polymerase II 3
chr18_-_70924708 11.55 ENSRNOT00000025257
lipase G, endothelial type
chr2_-_200762206 11.38 ENSRNOT00000068511
ENSRNOT00000086835
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2
chr1_+_222250995 11.35 ENSRNOT00000031458
tRNA phosphotransferase 1
chr10_-_87564327 11.28 ENSRNOT00000064760
ENSRNOT00000068237
similar to keratin associated protein 4-7
chr6_-_92643847 11.28 ENSRNOT00000009183
glycogen phosphorylase L
chr6_-_138550417 11.19 ENSRNOT00000071945

chrX_-_123092217 11.11 ENSRNOT00000039710
predicted gene 14569
chr20_-_34929965 11.01 ENSRNOT00000004499
minichromosome maintenance 9 homologous recombination repair factor
chr1_-_101651668 10.62 ENSRNOT00000028519
fucosyltransferase 2
chr19_-_56731372 10.52 ENSRNOT00000024182
nucleoporin 133
chr2_-_30664163 10.45 ENSRNOT00000024801
RAD17 checkpoint clamp loader component
chr8_-_62893087 10.38 ENSRNOT00000058490
coiled-coil domain containing 33
chr4_-_162025090 10.00 ENSRNOT00000085887
ENSRNOT00000009904
killer cell lectin-like receptor subfamily B, member 1A
chr14_-_5859581 9.98 ENSRNOT00000052308

chr15_-_42751330 9.78 ENSRNOT00000066478
ADAM metallopeptidase domain 2
chr3_-_2841331 9.46 ENSRNOT00000061874
coiled-coil domain containing 183
chr4_-_164536556 9.44 ENSRNOT00000087796
Ly49 inhibitory receptor 2
chr10_-_14630151 9.43 ENSRNOT00000024406
ubiquitin-conjugating enzyme E2I
chr14_-_82055290 9.41 ENSRNOT00000058062
RGD1560394
chr6_+_86852323 9.28 ENSRNOT00000059244
Fanconi anemia, complementation group M
chr4_-_122337389 9.13 ENSRNOT00000024222
cilia and flagella associated protein 100
chr3_-_7278758 9.08 ENSRNOT00000017004
sperm acrosome associated 9
chr2_-_189254628 9.03 ENSRNOT00000028234
interleukin 6 receptor
chr1_-_67284864 8.94 ENSRNOT00000082908
similar to zinc finger and SCAN domain containing 4
chr9_+_73418607 8.62 ENSRNOT00000092547
microtubule-associated protein 2
chrX_-_106576314 8.54 ENSRNOT00000037823
nuclear RNA export factor 3
chr17_-_10364503 8.52 ENSRNOT00000086380
ENSRNOT00000041709
tetraspanin 17
chr4_+_123801174 8.46 ENSRNOT00000029055
similar to chromosome 3 open reading frame 20
chr1_-_24982606 8.40 ENSRNOT00000074143
RGD1562660
chr20_-_6251634 8.39 ENSRNOT00000059194
serine/threonine kinase 38
chr7_+_2458264 8.26 ENSRNOT00000003550
nascent polypeptide-associated complex alpha subunit
chr9_+_16825845 8.25 ENSRNOT00000074821
ly6/PLAUR domain-containing protein 4-like
chr19_-_28666993 8.07 ENSRNOT00000083821

chr3_+_70327193 8.04 ENSRNOT00000089165
fibrous sheath-interacting protein 2
chr3_-_46601409 7.91 ENSRNOT00000079261
phospholipase A2 receptor 1
chr2_-_198439454 7.78 ENSRNOT00000028780
Fc fragment of IgG receptor Ia
chr1_-_84353725 7.60 ENSRNOT00000057177
phospholipase D family, member 3
chr9_-_104700609 7.39 ENSRNOT00000081815
ENSRNOT00000018503
solute carrier organic anion transporter family, member 6c1
chr19_-_28751584 7.31 ENSRNOT00000079270

chr9_+_16139101 7.30 ENSRNOT00000070803
uncharacterized LOC100910668
chr6_+_75429729 7.27 ENSRNOT00000043250
ribosomal protein S10-like 1
chr19_+_37600148 7.21 ENSRNOT00000023853
CCCTC-binding factor
chr3_-_13865843 7.09 ENSRNOT00000025194
Rab9 effector protein with kelch motifs
chr2_+_209358760 7.08 ENSRNOT00000082631
ligand dependent nuclear receptor interacting factor 1
chr19_-_42180981 7.00 ENSRNOT00000019577
polyamine modulated factor 1 binding protein 1
chr12_-_9727489 7.00 ENSRNOT00000001261
RNA polymerase I subunit D
chr11_+_82373870 6.85 ENSRNOT00000002429
transformer 2 beta homolog (Drosophila)
chr1_+_20022793 6.72 ENSRNOT00000061404
l(3)mbt-like 3 (Drosophila)
chr13_-_74005486 6.39 ENSRNOT00000090173

chr4_+_6282278 6.35 ENSRNOT00000010349
lysine methyltransferase 2C
chr19_-_28044531 6.35 ENSRNOT00000086160

chr20_+_48552289 6.35 ENSRNOT00000077926
cell division cycle 40
chr6_+_43363792 6.31 ENSRNOT00000091061
cleavage and polyadenylation specific factor 3
chr8_+_50563047 6.30 ENSRNOT00000025149
zinc finger protein 259
chr17_+_56109549 6.25 ENSRNOT00000022190
mitogen-activated protein kinase kinase kinase 8
chr11_+_67451549 6.24 ENSRNOT00000042777
stefin A2-like 2
chr4_+_118243132 6.23 ENSRNOT00000023654
similar to Hypothetical protein MGC25529
chr1_-_24891461 6.15 ENSRNOT00000049208
similar to spermatogenesis associated glutamate (E)-rich protein 4d
chr15_-_40545824 6.14 ENSRNOT00000017204
nucleoporin 58
chr10_-_57837602 6.11 ENSRNOT00000075185
NLR family, pyrin domain containing 1B
chr5_+_164972480 6.01 ENSRNOT00000012670
F-box protein 2
chr7_-_11406771 6.00 ENSRNOT00000047450
eukaryotic translation elongation factor 2
chr1_-_141533908 5.98 ENSRNOT00000020117
mesoderm posterior bHLH transcription factor 1
chr15_+_45422010 5.72 ENSRNOT00000012231
ribonuclease H2, subunit B
chr4_-_179700130 5.55 ENSRNOT00000021306
lamin tail domain containing 1
chr12_-_22478752 5.54 ENSRNOT00000089392
ENSRNOT00000086915
acetylcholinesterase
chr7_+_130542202 5.49 ENSRNOT00000079501
ENSRNOT00000045647
acrosin
chr19_+_52258947 5.43 ENSRNOT00000021072
adenosine deaminase domain containing 2
chr4_-_155867708 5.37 ENSRNOT00000051525
C-type lectin domain family 4, member A2
chr10_-_83655182 5.29 ENSRNOT00000007897
ABI family, member 3
chr8_+_117660964 5.25 ENSRNOT00000049240
transmembrane protein 89
chr1_+_196095214 5.22 ENSRNOT00000080741
similar to ribosomal protein S15a
chr10_+_109786222 5.20 ENSRNOT00000054953
neuropeptide B
chr16_+_69048730 5.16 ENSRNOT00000086082
ENSRNOT00000078128
RAB11 family interacting protein 1
chr2_-_206274079 5.03 ENSRNOT00000056079
homeodomain interacting protein kinase 1
chr7_+_123531682 4.96 ENSRNOT00000010606
WBP2 N-terminal like
chrX_-_124870329 4.91 ENSRNOT00000065023
cullin 4B
chrX_+_74497262 4.89 ENSRNOT00000003899
zinc finger CCHC-type containing 13
chr4_+_171250818 4.83 ENSRNOT00000040576
protein tyrosine phosphatase, receptor type, O
chr10_-_92602082 4.75 ENSRNOT00000007963
cell division cycle 27
chr4_-_164691405 4.75 ENSRNOT00000090979
ENSRNOT00000091932
ENSRNOT00000078219
Ly49 stimulatory receptor 4
Ly49 inhibitory receptor 2
chr13_+_84588351 4.75 ENSRNOT00000005090
transcriptional adaptor 1
chr3_+_2547986 4.42 ENSRNOT00000016846
mannosidase, alpha, class 1B, member 1
chr2_-_57196568 4.41 ENSRNOT00000060146
WD repeat domain 70
chr7_+_11054333 4.37 ENSRNOT00000007202
guanine nucleotide binding protein, alpha 15
chr17_+_79749747 4.33 ENSRNOT00000081743

chr9_-_61033553 4.29 ENSRNOT00000002864
ENSRNOT00000082681
general transcription factor IIIC subunit 3
chr3_+_152752091 4.29 ENSRNOT00000037177
DLG associated protein 4
chr10_-_103826448 4.28 ENSRNOT00000085636
ferredoxin reductase
chr9_+_38297322 4.05 ENSRNOT00000078157
ENSRNOT00000088824
BEN domain containing 6
chr19_+_248622 3.95 ENSRNOT00000078228

chr6_-_103187275 3.93 ENSRNOT00000083272
ribosomal protein L36-like
chr7_+_73270455 3.87 ENSRNOT00000007190
POP1 homolog, ribonuclease P/MRP subunit
chr9_-_81565416 3.85 ENSRNOT00000083582
angio-associated, migratory cell protein
chr3_+_71020534 3.84 ENSRNOT00000007276
zinc finger CCCH-type containing 15
chr10_+_70689863 3.80 ENSRNOT00000091122
ENSRNOT00000086987
ENSRNOT00000082030
TATA-box binding protein associated factor 15
chr11_+_86852711 3.78 ENSRNOT00000002581
DGCR8 microprocessor complex subunit
chr5_-_150704117 3.75 ENSRNOT00000067455
sestrin 2
chr7_-_27213651 3.70 ENSRNOT00000077041
ENSRNOT00000076468
thymine-DNA glycosylase
chr4_-_113764532 3.66 ENSRNOT00000009269
ssemaphorin 4F
chr4_+_87026530 3.65 ENSRNOT00000018425
AVL9 cell migration associated
chr7_-_130288509 3.61 ENSRNOT00000072955
SET binding factor 1
chr16_+_80729959 3.33 ENSRNOT00000082049
testis development related protein
chr15_+_32324830 3.30 ENSRNOT00000071598

chr16_-_86582984 3.13 ENSRNOT00000057349
similar to zinc finger protein, subfamily 1A, 5
chr1_-_263959318 3.11 ENSRNOT00000068007
polycystin 2 like 1, transient receptor potential cation channel
chr1_+_78069193 3.05 ENSRNOT00000068406
Meis homeobox 3
chr8_-_79119720 3.01 ENSRNOT00000086562
testis expressed 9
chr15_+_34926686 2.95 ENSRNOT00000045948
mast cell protease 1-like 3
chr1_+_89162639 2.92 ENSRNOT00000028508
ATPase H+/K+ transporting alpha subunit
chr10_+_71332803 2.88 ENSRNOT00000087428
synergin, gamma
chr7_-_129919946 2.61 ENSRNOT00000079976

chr3_-_161819029 2.60 ENSRNOT00000091834
engulfment and cell motility protein 2-like
chr5_-_143120165 2.56 ENSRNOT00000012314
zinc finger CCCH type containing 12A
chr6_-_91250138 2.53 ENSRNOT00000052408
ninein-like
chr17_+_57040023 2.52 ENSRNOT00000020204
cAMP responsive element modulator
chr20_+_47596575 2.50 ENSRNOT00000087230
ENSRNOT00000064905
sex comb on midleg-like 4 (Drosophila)
chr10_-_55997299 2.44 ENSRNOT00000074505
cytochrome b5 domain containing 1
chr10_+_71008709 2.36 ENSRNOT00000055923
WAP four-disulfide core domain 18
chr3_-_46051096 2.36 ENSRNOT00000081302
bromodomain adjacent to zinc finger domain, 2B
chr2_+_187990242 2.34 ENSRNOT00000092819
Rho/Rac guanine nucleotide exchange factor 2
chr7_+_117643206 2.33 ENSRNOT00000077588
aarF domain containing kinase 5
chr5_-_58288125 2.28 ENSRNOT00000068752
family with sequence similarity 205, member A
chr5_-_69752314 2.26 ENSRNOT00000024724
olfactory receptor 852
chr20_+_2044200 2.24 ENSRNOT00000092626
RT1 class Ib, locus M4
chr10_-_109840047 2.16 ENSRNOT00000054947
NOTUM, palmitoleoyl-protein carboxylesterase
chr9_+_98621506 2.15 ENSRNOT00000056612
ENSRNOT00000081992
TRAF3 interacting protein 1
chr3_-_125533600 2.07 ENSRNOT00000040802
leucine rich repeat neuronal 4
chr7_+_144503534 2.07 ENSRNOT00000021543
tubulin folding cofactor A
chr20_+_48504264 2.06 ENSRNOT00000087740
cell division cycle 40
chr5_-_151029233 1.96 ENSRNOT00000089155
protein phosphatase 1, regulatory subunit 8

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx21

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
8.9 35.6 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
8.3 33.1 GO:0060335 positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
7.0 21.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
4.7 14.0 GO:1904879 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure(GO:0001998) positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel(GO:1904879)
4.3 17.3 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
4.2 38.1 GO:0070543 response to linoleic acid(GO:0070543)
3.9 19.6 GO:0019371 cyclooxygenase pathway(GO:0019371)
3.8 11.5 GO:0010986 regulation of high-density lipoprotein particle clearance(GO:0010982) positive regulation of lipoprotein particle clearance(GO:0010986)
3.8 19.1 GO:0010989 negative regulation of low-density lipoprotein particle clearance(GO:0010989)
3.4 13.7 GO:0018992 germ-line sex determination(GO:0018992)
3.3 13.0 GO:0002337 B-1a B cell differentiation(GO:0002337)
3.1 21.8 GO:0035469 determination of pancreatic left/right asymmetry(GO:0035469)
3.0 6.0 GO:0090081 regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
3.0 26.7 GO:0010668 ectodermal cell differentiation(GO:0010668)
2.9 11.7 GO:0002386 immune response in mucosal-associated lymphoid tissue(GO:0002386)
2.9 14.5 GO:0006564 L-serine biosynthetic process(GO:0006564) threonine metabolic process(GO:0006566)
2.8 11.3 GO:0006015 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391)
2.8 8.3 GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
2.6 7.8 GO:0001788 antibody-dependent cellular cytotoxicity(GO:0001788)
1.9 11.4 GO:0034757 negative regulation of iron ion transport(GO:0034757)
1.8 9.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533) ciliary neurotrophic factor-mediated signaling pathway(GO:0070120)
1.8 21.2 GO:0006265 DNA topological change(GO:0006265)
1.8 14.1 GO:0009405 pathogenesis(GO:0009405)
1.6 19.4 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
1.6 6.3 GO:0030576 trophectodermal cell proliferation(GO:0001834) Cajal body organization(GO:0030576)
1.5 10.5 GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000972)
1.5 4.4 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
1.5 11.7 GO:0042795 snRNA transcription from RNA polymerase II promoter(GO:0042795)
1.2 3.7 GO:1902544 regulation of DNA N-glycosylase activity(GO:1902544)
1.2 6.0 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
1.2 17.4 GO:0051014 actin filament severing(GO:0051014)
1.1 7.9 GO:0090238 positive regulation of arachidonic acid secretion(GO:0090238) oxidative stress-induced premature senescence(GO:0090403)
1.1 20.0 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523) cellular response to low-density lipoprotein particle stimulus(GO:0071404)
1.1 6.3 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
1.0 11.3 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
1.0 3.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.9 3.8 GO:0031053 primary miRNA processing(GO:0031053)
0.9 3.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.9 8.3 GO:0033314 mitotic DNA replication checkpoint(GO:0033314)
0.9 7.2 GO:0010216 maintenance of DNA methylation(GO:0010216) nucleosome positioning(GO:0016584)
0.9 2.6 GO:1990869 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294) response to chemokine(GO:1990868) cellular response to chemokine(GO:1990869)
0.8 4.8 GO:0003105 negative regulation of glomerular filtration(GO:0003105)
0.8 15.2 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.8 5.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.8 4.6 GO:0070164 negative regulation of adiponectin secretion(GO:0070164)
0.8 0.8 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720)
0.8 10.6 GO:0036065 fucosylation(GO:0036065)
0.7 10.2 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.7 12.2 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.7 22.2 GO:0030033 microvillus assembly(GO:0030033)
0.7 12.0 GO:0042492 gamma-delta T cell differentiation(GO:0042492)
0.7 8.5 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.7 24.1 GO:0007080 mitotic metaphase plate congression(GO:0007080)
0.6 5.0 GO:0060235 lens induction in camera-type eye(GO:0060235)
0.6 5.5 GO:1900619 acetylcholine metabolic process(GO:0008291) acetate ester metabolic process(GO:1900619)
0.6 6.7 GO:0043249 erythrocyte maturation(GO:0043249)
0.6 9.5 GO:0036158 outer dynein arm assembly(GO:0036158)
0.6 14.1 GO:0048240 sperm capacitation(GO:0048240)
0.6 2.3 GO:0071802 negative regulation of podosome assembly(GO:0071802)
0.6 9.3 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.6 24.8 GO:0071427 mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.6 9.4 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.5 4.9 GO:0070914 UV-damage excision repair(GO:0070914)
0.5 16.7 GO:0019835 cytolysis(GO:0019835)
0.5 6.9 GO:0021796 cerebral cortex regionalization(GO:0021796)
0.5 6.3 GO:0061029 eyelid development in camera-type eye(GO:0061029)
0.4 3.1 GO:0050915 sensory perception of sour taste(GO:0050915)
0.4 5.7 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
0.4 6.0 GO:0006516 glycoprotein catabolic process(GO:0006516)
0.4 2.1 GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:1901621)
0.4 4.3 GO:0070995 NADPH oxidation(GO:0070995)
0.4 4.2 GO:0007343 egg activation(GO:0007343)
0.4 18.8 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.4 34.1 GO:0006342 chromatin silencing(GO:0006342)
0.4 6.8 GO:0070208 protein heterotrimerization(GO:0070208)
0.4 4.4 GO:0060158 phospholipase C-activating dopamine receptor signaling pathway(GO:0060158)
0.4 9.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.4 1.1 GO:0090648 regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation(GO:0060734) response to methyl methanesulfonate(GO:0072702) cellular response to methyl methanesulfonate(GO:0072703) response to environmental enrichment(GO:0090648) positive regulation of peptidyl-serine dephosphorylation(GO:1902310)
0.4 1.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.3 1.2 GO:2000293 regulation of defecation(GO:2000292) negative regulation of defecation(GO:2000293)
0.3 2.5 GO:0034454 microtubule anchoring at centrosome(GO:0034454)
0.3 4.3 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
0.3 6.1 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718)
0.3 2.1 GO:0007021 tubulin complex assembly(GO:0007021)
0.2 2.2 GO:0042159 lipoprotein catabolic process(GO:0042159)
0.2 8.6 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.2 13.5 GO:0048791 calcium ion-regulated exocytosis of neurotransmitter(GO:0048791)
0.2 0.4 GO:0048850 hypophysis morphogenesis(GO:0048850)
0.2 1.7 GO:0090315 negative regulation of protein targeting to membrane(GO:0090315)
0.2 10.9 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.2 1.6 GO:0010764 negative regulation of fibroblast migration(GO:0010764)
0.2 2.9 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248)
0.2 4.8 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.2 11.2 GO:0008542 visual learning(GO:0008542)
0.2 1.8 GO:0038094 Fc-gamma receptor signaling pathway(GO:0038094)
0.1 1.0 GO:2000381 negative regulation of mesoderm development(GO:2000381)
0.1 4.1 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.1 11.0 GO:0006334 nucleosome assembly(GO:0006334)
0.1 3.7 GO:0031290 retinal ganglion cell axon guidance(GO:0031290)
0.1 11.0 GO:0000724 double-strand break repair via homologous recombination(GO:0000724)
0.1 16.2 GO:0042476 odontogenesis(GO:0042476)
0.1 1.5 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.1 0.4 GO:0031119 tRNA pseudouridine synthesis(GO:0031119)
0.1 2.5 GO:0048384 retinoic acid receptor signaling pathway(GO:0048384)
0.1 1.3 GO:0060314 regulation of ryanodine-sensitive calcium-release channel activity(GO:0060314)
0.1 9.0 GO:0002244 hematopoietic progenitor cell differentiation(GO:0002244)
0.1 4.2 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.3 GO:0009181 purine nucleoside diphosphate catabolic process(GO:0009137) purine ribonucleoside diphosphate catabolic process(GO:0009181)
0.0 1.8 GO:0006458 'de novo' protein folding(GO:0006458)
0.0 4.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 1.4 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 1.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.3 GO:0046839 phospholipid dephosphorylation(GO:0046839)
0.0 8.4 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 1.1 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.0 GO:0035308 negative regulation of protein dephosphorylation(GO:0035308)
0.0 1.8 GO:0032680 regulation of tumor necrosis factor production(GO:0032680)
0.0 9.6 GO:0048232 spermatogenesis(GO:0007283) male gamete generation(GO:0048232)
0.0 5.3 GO:0018108 peptidyl-tyrosine phosphorylation(GO:0018108)
0.0 3.1 GO:2001234 negative regulation of apoptotic signaling pathway(GO:2001234)
0.0 0.6 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.5 GO:0043488 regulation of mRNA stability(GO:0043488)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 9.0 GO:0070110 interleukin-6 receptor complex(GO:0005896) ciliary neurotrophic factor receptor complex(GO:0070110)
2.4 12.1 GO:1990130 Iml1 complex(GO:1990130)
2.3 14.1 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
1.4 5.7 GO:0032299 ribonuclease H2 complex(GO:0032299)
1.3 3.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.3 45.2 GO:0008305 integrin complex(GO:0008305)
1.1 5.5 GO:0043159 acrosomal matrix(GO:0043159)
1.0 9.3 GO:0071821 FANCM-MHF complex(GO:0071821)
1.0 11.0 GO:0042555 MCM complex(GO:0042555)
1.0 4.9 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
1.0 8.6 GO:0097442 CA3 pyramidal cell dendrite(GO:0097442)
1.0 10.5 GO:0031080 nuclear pore outer ring(GO:0031080)
0.9 18.7 GO:0033391 chromatoid body(GO:0033391)
0.9 6.3 GO:0097504 Gemini of coiled bodies(GO:0097504)
0.9 6.1 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.8 15.2 GO:0042589 zymogen granule membrane(GO:0042589)
0.6 4.3 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.6 6.0 GO:0042788 polysomal ribosome(GO:0042788)
0.6 7.0 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.6 4.4 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.5 6.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.5 70.6 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.5 27.9 GO:0005637 nuclear inner membrane(GO:0005637)
0.5 3.8 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.5 45.0 GO:0000786 nucleosome(GO:0000786)
0.4 2.6 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.4 6.3 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.4 7.0 GO:0001520 outer dense fiber(GO:0001520)
0.4 24.1 GO:0005871 kinesin complex(GO:0005871)
0.4 5.5 GO:0043083 synaptic cleft(GO:0043083)
0.3 22.0 GO:0045335 phagocytic vesicle(GO:0045335)
0.3 33.4 GO:0097014 axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.3 24.2 GO:0005798 Golgi-associated vesicle(GO:0005798)
0.3 3.3 GO:0030914 STAGA complex(GO:0030914)
0.2 1.4 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.2 4.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.2 12.2 GO:0015030 Cajal body(GO:0015030)
0.2 11.7 GO:0008023 transcription elongation factor complex(GO:0008023)
0.2 13.5 GO:0019897 extrinsic component of plasma membrane(GO:0019897)
0.2 13.7 GO:0030667 secretory granule membrane(GO:0030667)
0.2 3.8 GO:1902555 endoribonuclease complex(GO:1902555)
0.2 62.2 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 14.0 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.2 18.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.2 18.2 GO:0016605 PML body(GO:0016605)
0.2 17.5 GO:0000781 chromosome, telomeric region(GO:0000781)
0.2 1.8 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 0.8 GO:1990357 terminal web(GO:1990357)
0.1 3.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 24.6 GO:0030027 lamellipodium(GO:0030027)
0.1 7.4 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 19.6 GO:0008021 synaptic vesicle(GO:0008021)
0.1 30.0 GO:0005874 microtubule(GO:0005874)
0.1 7.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 34.5 GO:0000790 nuclear chromatin(GO:0000790)
0.1 1.2 GO:0070852 varicosity(GO:0043196) cell body fiber(GO:0070852)
0.1 4.8 GO:0016328 lateral plasma membrane(GO:0016328)
0.1 14.1 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 9.9 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.1 14.5 GO:0043209 myelin sheath(GO:0043209)
0.1 0.3 GO:0031428 box C/D snoRNP complex(GO:0031428)
0.1 1.8 GO:0097546 ciliary base(GO:0097546)
0.1 0.7 GO:0044613 nuclear pore central transport channel(GO:0044613)
0.1 7.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.1 3.6 GO:0055037 recycling endosome(GO:0055037)
0.1 0.5 GO:0060293 P granule(GO:0043186) pole plasm(GO:0045495) germ plasm(GO:0060293)
0.1 12.6 GO:0031965 nuclear membrane(GO:0031965)
0.1 3.1 GO:0034704 calcium channel complex(GO:0034704)
0.1 7.1 GO:0010008 endosome membrane(GO:0010008)
0.1 1.6 GO:0035869 ciliary transition zone(GO:0035869)
0.0 9.8 GO:0005769 early endosome(GO:0005769)
0.0 0.2 GO:0030122 AP-2 adaptor complex(GO:0030122)
0.0 1.3 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.0 2.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.0 8.1 GO:0043235 receptor complex(GO:0043235)
0.0 1.4 GO:0016592 mediator complex(GO:0016592)
0.0 1.5 GO:0005770 late endosome(GO:0005770)
0.0 0.3 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.0 1.4 GO:0030496 midbody(GO:0030496)
0.0 5.2 GO:0005840 ribosome(GO:0005840)
0.0 5.9 GO:0031966 mitochondrial membrane(GO:0031966)
0.0 5.4 GO:0031410 cytoplasmic vesicle(GO:0031410)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 20.5 GO:0004522 ribonuclease A activity(GO:0004522)
6.5 19.6 GO:0008481 sphinganine kinase activity(GO:0008481)
5.3 21.2 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
3.8 11.4 GO:0004769 steroid delta-isomerase activity(GO:0004769)
3.8 11.3 GO:0002060 purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184)
3.5 10.6 GO:0031127 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
3.3 13.0 GO:0001225 RNA polymerase II transcription coactivator binding(GO:0001225)
3.1 9.4 GO:0043398 HLH domain binding(GO:0043398)
2.4 12.2 GO:0004140 dephospho-CoA kinase activity(GO:0004140)
2.3 9.0 GO:0004897 ciliary neurotrophic factor receptor activity(GO:0004897)
2.2 15.2 GO:0035375 zymogen binding(GO:0035375)
2.0 36.8 GO:0005522 profilin binding(GO:0005522)
1.9 11.5 GO:0008970 phosphatidylcholine 1-acylhydrolase activity(GO:0008970)
1.9 9.6 GO:0019770 IgG receptor activity(GO:0019770)
1.8 5.5 GO:0003990 acetylcholinesterase activity(GO:0003990)
1.8 5.5 GO:0004040 amidase activity(GO:0004040)
1.7 38.1 GO:0051861 glycolipid binding(GO:0051861)
1.6 17.3 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
1.3 3.9 GO:0000171 ribonuclease MRP activity(GO:0000171)
1.3 7.6 GO:0070290 N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290)
1.2 3.7 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
1.1 5.7 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
1.1 4.3 GO:0000995 transcription factor activity, core RNA polymerase III binding(GO:0000995)
1.0 10.4 GO:0033170 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
1.0 13.5 GO:0042043 neurexin family protein binding(GO:0042043)
0.9 3.8 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.9 17.7 GO:0003993 acid phosphatase activity(GO:0003993)
0.9 14.0 GO:0005536 glucose binding(GO:0005536)
0.9 52.2 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.8 21.8 GO:0070840 dynein complex binding(GO:0070840)
0.7 2.9 GO:0008900 hydrogen:potassium-exchanging ATPase activity(GO:0008900)
0.7 17.4 GO:0005487 nucleocytoplasmic transporter activity(GO:0005487)
0.6 18.4 GO:0031683 G-protein beta/gamma-subunit complex binding(GO:0031683)
0.6 3.8 GO:0070728 leucine binding(GO:0070728)
0.5 6.0 GO:0008097 5S rRNA binding(GO:0008097)
0.5 4.4 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.5 6.1 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.5 5.4 GO:0004000 adenosine deaminase activity(GO:0004000)
0.4 61.3 GO:0001948 glycoprotein binding(GO:0001948)
0.4 6.3 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.4 7.9 GO:0043274 phospholipase binding(GO:0043274)
0.4 9.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.3 6.9 GO:0070717 poly-purine tract binding(GO:0070717)
0.3 21.2 GO:0003724 RNA helicase activity(GO:0003724) ATP-dependent RNA helicase activity(GO:0004004)
0.3 1.2 GO:0015056 corticotrophin-releasing factor receptor activity(GO:0015056) corticotropin-releasing hormone receptor activity(GO:0043404)
0.3 8.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.3 24.1 GO:0003777 microtubule motor activity(GO:0003777)
0.3 13.4 GO:0005044 scavenger receptor activity(GO:0005044)
0.3 6.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.2 1.7 GO:0031433 telethonin binding(GO:0031433)
0.2 8.3 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 4.3 GO:0070402 NADPH binding(GO:0070402)
0.2 1.1 GO:0001093 TFIIB-class transcription factor binding(GO:0001093) MRF binding(GO:0043426)
0.2 21.0 GO:0005178 integrin binding(GO:0005178)
0.2 2.6 GO:0035925 miRNA binding(GO:0035198) mRNA 3'-UTR AU-rich region binding(GO:0035925)
0.2 14.5 GO:0051287 NAD binding(GO:0051287)
0.2 0.7 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.2 7.1 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.2 4.8 GO:0017147 Wnt-protein binding(GO:0017147)
0.2 5.0 GO:0050699 WW domain binding(GO:0050699)
0.2 44.4 GO:0030246 carbohydrate binding(GO:0030246)
0.2 17.7 GO:0035326 enhancer binding(GO:0035326)
0.1 9.1 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.1 11.7 GO:0003823 antigen binding(GO:0003823)
0.1 4.1 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
0.1 1.3 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 4.2 GO:0031369 translation initiation factor binding(GO:0031369)
0.1 31.6 GO:0015631 tubulin binding(GO:0015631)
0.1 0.3 GO:0034512 box C/D snoRNA binding(GO:0034512)
0.1 4.9 GO:0003684 damaged DNA binding(GO:0003684)
0.1 1.5 GO:0004935 adrenergic receptor activity(GO:0004935)
0.1 3.3 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 3.9 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 9.8 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 3.1 GO:0005272 sodium channel activity(GO:0005272)
0.1 1.8 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 37.2 GO:0046982 protein heterodimerization activity(GO:0046982)
0.1 0.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.3 GO:0047631 adenosine-diphosphatase activity(GO:0043262) ADP-ribose diphosphatase activity(GO:0047631)
0.0 1.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.0 4.8 GO:0019903 protein phosphatase binding(GO:0019903)
0.0 2.5 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 1.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 6.4 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 1.4 GO:0001104 RNA polymerase II transcription cofactor activity(GO:0001104)
0.0 11.9 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.0 5.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.4 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.1 GO:0045296 cadherin binding(GO:0045296)
0.0 0.5 GO:0005245 voltage-gated calcium channel activity(GO:0005245)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.7 35.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
2.6 47.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.6 45.2 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
1.0 23.9 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.7 9.4 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.7 14.1 PID LPA4 PATHWAY LPA4-mediated signaling events
0.6 32.2 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.5 6.2 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.4 19.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.3 9.8 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.3 7.6 ST GAQ PATHWAY G alpha q Pathway
0.3 18.8 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.1 5.5 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 2.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.1 6.0 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 2.3 PID REELIN PATHWAY Reelin signaling pathway
0.1 4.3 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 1.1 PID NFAT 3PATHWAY Role of Calcineurin-dependent NFAT signaling in lymphocytes
0.0 3.8 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.1 PID LKB1 PATHWAY LKB1 signaling events
0.0 1.4 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.1 PID BMP PATHWAY BMP receptor signaling
0.0 3.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 14.1 REACTOME OLFACTORY SIGNALING PATHWAY Genes involved in Olfactory Signaling Pathway
1.7 19.1 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.7 78.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.7 17.3 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
1.0 19.4 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.9 11.4 REACTOME ANDROGEN BIOSYNTHESIS Genes involved in Androgen biosynthesis
0.8 14.5 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.8 24.1 REACTOME KINESINS Genes involved in Kinesins
0.7 9.0 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.6 19.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.6 11.3 REACTOME GLYCOGEN BREAKDOWN GLYCOGENOLYSIS Genes involved in Glycogen breakdown (glycogenolysis)
0.5 17.5 REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
0.5 11.9 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.4 4.4 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.4 4.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 11.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.4 8.4 REACTOME TRANSPORT OF MATURE TRANSCRIPT TO CYTOPLASM Genes involved in Transport of Mature Transcript to Cytoplasm
0.3 9.4 REACTOME MEIOTIC SYNAPSIS Genes involved in Meiotic Synapsis
0.3 9.3 REACTOME FANCONI ANEMIA PATHWAY Genes involved in Fanconi Anemia pathway
0.3 4.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.3 3.8 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.3 3.7 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.3 10.4 REACTOME ACTIVATION OF ATR IN RESPONSE TO REPLICATION STRESS Genes involved in Activation of ATR in response to replication stress
0.2 6.2 REACTOME CD28 DEPENDENT PI3K AKT SIGNALING Genes involved in CD28 dependent PI3K/Akt signaling
0.2 5.5 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.2 7.8 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.1 2.1 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.1 7.6 REACTOME GLYCEROPHOSPHOLIPID BIOSYNTHESIS Genes involved in Glycerophospholipid biosynthesis
0.1 1.1 REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY Genes involved in TRAF3-dependent IRF activation pathway
0.1 2.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 14.0 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 6.0 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.0 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 1.1 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 2.3 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.2 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.0 1.2 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)