ISMARA results: Tbx21

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx21

Z-value: 1.37

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Transcription factors associated with Tbx21

Gene Symbol	Gene ID	Gene Info
Tbx21 NCBI RGD Ensembl	ENSRNOG00000009427	T-box 21

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbx21	rn6_v1_chr10_-_85049331_85049331	0.37	1.0e-11	Click!

Activity profile of Tbx21 motif

Sorted Z-values of Tbx21 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_138239306 Show fit	39.24	ENSRNOT00000039305	Ermap NCBI RGD Ensembl Show fit	erythroblast membrane-associated protein
chr13_+_82369493 Show fit	38.13	ENSRNOT00000003733	Sell NCBI RGD Ensembl Show fit	selectin L
chr6_-_138550576 Show fit	37.49	ENSRNOT00000075284	AABR07065645.1 NCBI RGD Ensembl Show fit
chr6_-_138744480 Show fit	35.49	ENSRNOT00000089387	AABR07065651.5 NCBI RGD Ensembl Show fit
chr14_+_38030189 Show fit	33.09	ENSRNOT00000035623	Txk NCBI RGD Ensembl Show fit	TXK tyrosine kinase
chr6_-_138909105 Show fit	26.90	ENSRNOT00000087855	AABR07065656.9 NCBI RGD Ensembl Show fit
chr7_+_140758615 Show fit	26.84	ENSRNOT00000089448	Troap NCBI RGD Ensembl Show fit	trophinin associated protein
chr1_+_199495298 Show fit	26.72	ENSRNOT00000086003 ENSRNOT00000026748	Itgad NCBI RGD Ensembl Show fit	integrin subunit alpha D
chr8_-_36760742 Show fit	24.76	ENSRNOT00000017307	Ddx25 NCBI RGD Ensembl Show fit	DEAD-box helicase 25
chr6_-_28967902 Show fit	24.64	ENSRNOT00000032664	Mfsd2b NCBI RGD Ensembl Show fit	major facilitator superfamily domain containing 2B

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx21

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.2	38.1	GO:0070543	response to linoleic acid(GO:0070543)
8.9	35.6	GO:0070495	regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4	34.1	GO:0006342	chromatin silencing(GO:0006342)
8.3	33.1	GO:0060335	positive regulation of response to interferon-gamma(GO:0060332) positive regulation of interferon-gamma-mediated signaling pathway(GO:0060335)
3.0	26.7	GO:0010668	ectodermal cell differentiation(GO:0010668)
0.6	24.8	GO:0071427	mRNA export from nucleus(GO:0006406) mRNA-containing ribonucleoprotein complex export from nucleus(GO:0071427)
0.7	24.1	GO:0007080	mitotic metaphase plate congression(GO:0007080)
0.7	22.2	GO:0030033	microvillus assembly(GO:0030033)
3.1	21.8	GO:0035469	determination of pancreatic left/right asymmetry(GO:0035469)
1.8	21.2	GO:0006265	DNA topological change(GO:0006265)

Showing 1 to 10 of 122 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	70.6	GO:0031234	extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.2	62.2	GO:0009897	external side of plasma membrane(GO:0009897)
1.3	45.2	GO:0008305	integrin complex(GO:0008305)
0.5	45.0	GO:0000786	nucleosome(GO:0000786)
0.1	34.5	GO:0000790	nuclear chromatin(GO:0000790)
0.3	33.4	GO:0097014	axoneme(GO:0005930) ciliary plasm(GO:0097014)
0.1	30.0	GO:0005874	microtubule(GO:0005874)
0.5	27.9	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	24.6	GO:0030027	lamellipodium(GO:0030027)
0.3	24.2	GO:0005798	Golgi-associated vesicle(GO:0005798)

Showing 1 to 10 of 82 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.4	61.3	GO:0001948	glycoprotein binding(GO:0001948)
0.9	52.2	GO:0004715	non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2	44.4	GO:0030246	carbohydrate binding(GO:0030246)
1.7	38.1	GO:0051861	glycolipid binding(GO:0051861)
0.1	37.2	GO:0046982	protein heterodimerization activity(GO:0046982)
2.0	36.8	GO:0005522	profilin binding(GO:0005522)
0.1	31.6	GO:0015631	tubulin binding(GO:0015631)
0.3	24.1	GO:0003777	microtubule motor activity(GO:0003777)
0.8	21.8	GO:0070840	dynein complex binding(GO:0070840)
5.3	21.2	GO:0044378	non-sequence-specific DNA binding, bending(GO:0044378)

Showing 1 to 10 of 92 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.6	47.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
1.6	45.2	PID INTEGRIN CS PATHWAY	Integrin family cell surface interactions
2.7	35.6	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.6	32.2	SIG BCR SIGNALING PATHWAY	Members of the BCR signaling pathway
1.0	23.9	PID S1P META PATHWAY	Sphingosine 1-phosphate (S1P) pathway
0.4	19.7	PID FANCONI PATHWAY	Fanconi anemia pathway
0.3	18.8	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.7	14.1	PID LPA4 PATHWAY	LPA4-mediated signaling events
0.3	9.8	PID INTEGRIN A9B1 PATHWAY	Alpha9 beta1 integrin signaling events
0.7	9.4	PID RANBP2 PATHWAY	Sumoylation by RanBP2 regulates transcriptional repression

Showing 1 to 10 of 23 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.7	78.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.8	24.1	REACTOME KINESINS	Genes involved in Kinesins
0.6	19.6	REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS	Genes involved in Association of TriC/CCT with target proteins during biosynthesis
1.0	19.4	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
1.7	19.1	REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS	Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5	17.5	REACTOME TRANSPORT OF MATURE MRNA DERIVED FROM AN INTRONLESS TRANSCRIPT	Genes involved in Transport of Mature mRNA Derived from an Intronless Transcript
1.7	17.3	REACTOME PURINE CATABOLISM	Genes involved in Purine catabolism
0.8	14.5	REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION	Genes involved in Amino acid synthesis and interconversion (transamination)
2.3	14.1	REACTOME OLFACTORY SIGNALING PATHWAY	Genes involved in Olfactory Signaling Pathway
0.1	14.0	REACTOME METABOLISM OF CARBOHYDRATES	Genes involved in Metabolism of carbohydrates

Showing 1 to 10 of 38 entries

Results for Tbx21

Z-value: 1.37

Motif logo

Transcription factors associated with Tbx21

Activity-expression correlation:

Activity profile of Tbx21 motif

Sorted Z-values of Tbx21 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx21

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: