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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx2

Z-value: 0.75

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Transcription factors associated with Tbx2

Gene Symbol Gene ID Gene Info
Tbx2
ENSRNOG00000003517 T-box 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tbx2rn6_v1_chr10_+_73279119_732791190.018.2e-01Click!

Activity profile of Tbx2 motif

Sorted Z-values of Tbx2 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_164808323 51.76 ENSRNOT00000011005
Nppa
natriuretic peptide A
chr2_-_45077219 47.51 ENSRNOT00000014319
Gzmk
granzyme K
chr8_-_107952530 24.52 ENSRNOT00000052043
Cldn18
claudin 18
chr1_-_197821936 24.03 ENSRNOT00000055027
Cd19
CD19 molecule
chr8_+_58431407 19.08 ENSRNOT00000011974
Sln
sarcolipin
chr1_+_196996581 18.67 ENSRNOT00000021690
Il21r
interleukin 21 receptor
chrX_+_134979646 18.28 ENSRNOT00000006035
Sash3
SAM and SH3 domain containing 3
chrX_+_128897181 18.16 ENSRNOT00000008444
Sh2d1a
SH2 domain containing 1A
chr1_+_87938042 16.26 ENSRNOT00000027837
Map4k1
mitogen activated protein kinase kinase kinase kinase 1
chr14_-_14390699 16.00 ENSRNOT00000046639
Anxa3
annexin A3
chr1_-_20155960 15.14 ENSRNOT00000061389
Samd3
sterile alpha motif domain containing 3
chr16_-_49574314 14.63 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
Pdlim3
PDZ and LIM domain 3
chr13_-_85443976 11.22 ENSRNOT00000005213
Uck2
uridine-cytidine kinase 2
chrX_+_70563570 11.05 ENSRNOT00000003772
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr7_-_12635943 10.97 ENSRNOT00000015029
Cfd
complement factor D
chr15_+_28295368 10.19 ENSRNOT00000013786
Slc39a2
solute carrier family 39 member 2
chr5_+_24434872 9.57 ENSRNOT00000010696
Ccne2
cyclin E2
chr20_-_4677034 9.56 ENSRNOT00000075244
Rn60_20_0047.3

chrX_-_62690806 8.99 ENSRNOT00000018147
Pola1
DNA polymerase alpha 1, catalytic subunit
chr9_+_98505259 8.18 ENSRNOT00000051810
Erfe
erythroferrone
chr3_+_170994038 8.06 ENSRNOT00000081823
Spo11
SPO11, initiator of meiotic double stranded breaks
chr13_-_47154292 8.04 ENSRNOT00000005284
Cd55
CD55 molecule, decay accelerating factor for complement
chr9_-_78693028 7.87 ENSRNOT00000036359
Abca12
ATP binding cassette subfamily A member 12
chr1_-_124803363 7.87 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr10_+_49541051 7.85 ENSRNOT00000041606
Pmp22
peripheral myelin protein 22
chr13_-_85443727 7.69 ENSRNOT00000090668
ENSRNOT00000076125
Uck2
uridine-cytidine kinase 2
chr4_-_155421998 7.42 ENSRNOT00000041552
Gdf3
growth differentiation factor 3
chr6_-_142880382 6.86 ENSRNOT00000074706
ENSRNOT00000072861
AABR07065821.1

chr12_-_3924415 6.69 ENSRNOT00000067752
AABR07035074.1

chr3_+_153580861 6.46 ENSRNOT00000080516
ENSRNOT00000012739
Src
SRC proto-oncogene, non-receptor tyrosine kinase
chr13_+_82429063 6.38 ENSRNOT00000076879
Selp
selectin P
chr2_-_251532312 6.36 ENSRNOT00000019501
Cyr61
cysteine-rich, angiogenic inducer, 61
chr20_-_4677506 6.30 ENSRNOT00000061297
RT1-CE6
RT1 class I, locus CE6
chr6_-_143206772 6.18 ENSRNOT00000073713
AABR07065839.1

chr3_-_66335869 6.13 ENSRNOT00000079781
ENSRNOT00000043238
ENSRNOT00000073412
ENSRNOT00000057878
ENSRNOT00000079212
Cerkl
ceramide kinase-like
chr19_+_39063998 5.94 ENSRNOT00000081116
Has3
hyaluronan synthase 3
chr19_+_33932532 5.86 ENSRNOT00000078395
ENSRNOT00000091985
ENSRNOT00000078701
ENSRNOT00000080317
Ednra
endothelin receptor type A
chr12_+_41385241 5.77 ENSRNOT00000074974
Dtx1
deltex E3 ubiquitin ligase 1
chr17_-_15467320 5.76 ENSRNOT00000072490
ENSRNOT00000093561
Ogn
osteoglycin
chr8_-_45215974 5.69 ENSRNOT00000010792
Crtam
cytotoxic and regulatory T cell molecule
chr4_+_49369296 5.60 ENSRNOT00000007822
Wnt16
wingless-type MMTV integration site family, member 16
chrX_+_104734082 5.49 ENSRNOT00000005020
Srpx2
sushi-repeat-containing protein, X-linked 2
chr17_-_89163113 5.41 ENSRNOT00000050445
LOC100360843
ribosomal protein S19-like
chr6_+_109300433 5.39 ENSRNOT00000010712
Fos
FBJ osteosarcoma oncogene
chr15_+_30735921 4.95 ENSRNOT00000078887
AABR07017763.2

chr19_-_37907714 4.68 ENSRNOT00000026361
Ctrl
chymotrypsin-like
chr10_+_63778755 4.57 ENSRNOT00000090481
Inpp5k
inositol polyphosphate-5-phosphatase K
chr1_-_214423881 4.57 ENSRNOT00000025290
Pidd1
p53-induced death domain protein 1
chr20_-_3728844 4.24 ENSRNOT00000074958
Psors1c2
psoriasis susceptibility 1 candidate 2
chr3_-_164388492 4.16 ENSRNOT00000090493
Tmem189
transmembrane protein 189
chr1_+_22332090 4.12 ENSRNOT00000091252
AABR07000663.1
trace amine-associated receptor 8c (Taar8c), mRNA
chr1_-_141533908 4.08 ENSRNOT00000020117
Mesp1
mesoderm posterior bHLH transcription factor 1
chr1_-_172567846 3.89 ENSRNOT00000012974
Olr259
olfactory receptor 259
chr7_-_62972084 3.81 ENSRNOT00000064251
Msrb3
methionine sulfoxide reductase B3
chr10_-_56511583 3.81 ENSRNOT00000021402
LOC497940
similar to RIKEN cDNA 2810408A11
chr8_-_75995371 3.81 ENSRNOT00000014014
Foxb1
forkhead box B1
chr5_-_171415354 3.62 ENSRNOT00000055398
Tp73
tumor protein p73
chr1_+_141550633 3.52 ENSRNOT00000020047
Mesp2
mesoderm posterior bHLH transcription factor 2
chr5_-_57845509 3.38 ENSRNOT00000035541
Kif24
kinesin family member 24
chr6_-_11860001 3.30 ENSRNOT00000052280
H2afz
H2A histone family, member Z
chr14_-_21709084 3.23 ENSRNOT00000087477
Smr3b
submaxillary gland androgen regulated protein 3B
chr1_+_85003280 3.02 ENSRNOT00000057122
Fcgbp
Fc fragment of IgG binding protein
chr19_+_12097632 2.94 ENSRNOT00000049452
Ces5a
carboxylesterase 5A
chr5_-_140834950 2.48 ENSRNOT00000043799
ENSRNOT00000089980
Ppie
peptidylprolyl isomerase E
chr1_+_187149453 2.48 ENSRNOT00000082738
Xylt1
xylosyltransferase 1
chr6_-_50923510 2.42 ENSRNOT00000010631
Bcap29
B-cell receptor-associated protein 29
chr6_-_103605256 2.41 ENSRNOT00000006005
Dcaf5
DDB1 and CUL4 associated factor 5
chr4_-_55527092 2.40 ENSRNOT00000087407
ENSRNOT00000010223
Zfp800
zinc finger protein 800
chrX_+_33599671 2.38 ENSRNOT00000006843
Txlng
taxilin gamma
chr20_+_6356423 2.38 ENSRNOT00000000628
Cdkn1a
cyclin-dependent kinase inhibitor 1A
chr18_+_72571327 2.37 ENSRNOT00000089468
Smad2
SMAD family member 2
chr1_+_168378637 2.27 ENSRNOT00000028936
Olr86
olfactory receptor 86
chr7_-_11406771 2.23 ENSRNOT00000047450
Eef2
eukaryotic translation elongation factor 2
chr17_+_72240802 2.18 ENSRNOT00000025993
ENSRNOT00000090453
Atp5c1
ATP synthase, H+ transporting, mitochondrial F1 complex, gamma polypeptide 1
chr5_+_50381244 2.00 ENSRNOT00000012385
Cga
glycoprotein hormones, alpha polypeptide
chr1_+_22364551 1.99 ENSRNOT00000043157
LOC108348200
trace amine-associated receptor 8a
chr19_-_31867850 1.97 ENSRNOT00000024689
Anapc10
anaphase promoting complex subunit 10
chr2_+_140471690 1.89 ENSRNOT00000017379
Naa15
N(alpha)-acetyltransferase 15, NatA auxiliary subunit
chr17_-_14828329 1.87 ENSRNOT00000022830
Barx1
BARX homeobox 1
chr8_+_41285450 1.77 ENSRNOT00000076562
Olr1222
olfactory receptor 1222
chr5_+_159671136 1.64 ENSRNOT00000084737
Fbxo42
F-box protein 42
chr4_-_145678066 1.63 ENSRNOT00000014103
Ghrl
ghrelin and obestatin prepropeptide
chr16_+_61130755 1.63 ENSRNOT00000042609
AABR07026048.1

chr5_-_171710312 1.57 ENSRNOT00000076044
ENSRNOT00000071280
ENSRNOT00000072059
ENSRNOT00000077015
Prdm16
PR/SET domain 16
chr2_+_211880262 1.56 ENSRNOT00000038315
Slc25a54
solute carrier family 25, member 54
chr18_+_69549937 1.48 ENSRNOT00000041227
Mex3c
mex-3 RNA binding family member C
chr3_-_94419048 1.47 ENSRNOT00000015775
Hipk3
homeodomain interacting protein kinase 3
chr4_+_1584083 1.45 ENSRNOT00000087099
Olr1244
olfactory receptor 1244
chr5_+_113592919 1.44 ENSRNOT00000011336
Ift74
intraflagellar transport 74
chr18_+_16616937 1.41 ENSRNOT00000093641
Mocos
molybdenum cofactor sulfurase
chr1_-_142500367 1.40 ENSRNOT00000015948
ENSRNOT00000089591
Crtc3
CREB regulated transcription coactivator 3
chr2_+_198755262 1.21 ENSRNOT00000028807
Rbm8a
RNA binding motif protein 8A
chr7_+_143679617 1.20 ENSRNOT00000014033
Eif4b
eukaryotic translation initiation factor 4B
chr1_+_100224401 1.19 ENSRNOT00000025846
Fv1
Friend virus susceptibility 1
chr4_+_71675383 1.17 ENSRNOT00000051265
Clcn1
chloride voltage-gated channel 1
chr8_+_118744229 1.05 ENSRNOT00000028364
Kif9
kinesin family member 9
chr10_-_88645364 0.98 ENSRNOT00000030344
Rab5c
RAB5C, member RAS oncogene family
chr4_+_1658278 0.96 ENSRNOT00000073845
Olr1250
olfactory receptor 1250
chr7_-_126382449 0.84 ENSRNOT00000085540
7530416G11Rik
RIKEN cDNA 7530416G11 gene
chr8_+_41936959 0.79 ENSRNOT00000042601
Olr1222
olfactory receptor 1222
chr7_-_120839577 0.74 ENSRNOT00000018526
Dmc1
DNA meiotic recombinase 1
chr1_-_22404002 0.49 ENSRNOT00000044098
Taar8a
trace amine-associated receptor 8a
chr19_-_25288335 0.44 ENSRNOT00000050214
Nanos3
nanos C2HC-type zinc finger 3
chr1_-_172616633 0.43 ENSRNOT00000012919
Olr262
olfactory receptor 262
chr3_-_149563476 0.37 ENSRNOT00000071869
AABR07054352.2

chr9_+_21045457 0.34 ENSRNOT00000031759
Opn5
opsin 5
chr11_-_61530567 0.33 ENSRNOT00000076277
Naa50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr9_+_70310932 0.29 ENSRNOT00000088268
LOC103690541
uncharacterized LOC103690541
chr7_-_141624972 0.23 ENSRNOT00000078785
AABR07058884.1

chr18_+_25613831 0.22 ENSRNOT00000091040
Tslp
thymic stromal lymphopoietin
chr7_-_122926336 0.20 ENSRNOT00000000205
Chadl
chondroadherin-like
chr1_+_168623150 0.16 ENSRNOT00000021282
Olr107
olfactory receptor 107
chr11_+_75905443 0.14 ENSRNOT00000002650
Fgf12
fibroblast growth factor 12
chr1_-_169386939 0.04 ENSRNOT00000023007
Olr150
olfactory receptor 150

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
17.3 51.8 GO:1902304 positive regulation of potassium ion export(GO:1902304)
8.2 24.5 GO:2001205 negative regulation of osteoclast development(GO:2001205)
4.7 18.9 GO:0044211 CTP salvage(GO:0044211)
3.0 42.2 GO:0006968 cellular defense response(GO:0006968)
2.7 19.1 GO:1901894 regulation of calcium-transporting ATPase activity(GO:1901894)
2.2 9.0 GO:0006272 leading strand elongation(GO:0006272)
2.0 8.0 GO:0030450 regulation of complement activation, classical pathway(GO:0030450)
1.6 8.1 GO:1990918 meiotic DNA double-strand break processing(GO:0000706) double-strand break repair involved in meiotic recombination(GO:1990918)
1.6 7.9 GO:0035627 ceramide transport(GO:0035627)
1.5 5.9 GO:0036118 hyaluranon cable assembly(GO:0036118) extracellular polysaccharide biosynthetic process(GO:0045226) extracellular polysaccharide metabolic process(GO:0046379) regulation of hyaluranon cable assembly(GO:1900104) positive regulation of hyaluranon cable assembly(GO:1900106)
1.4 4.1 GO:0060974 cell migration involved in heart formation(GO:0060974) regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
1.3 18.3 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
1.3 6.5 GO:0051902 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641) negative regulation of mitochondrial depolarization(GO:0051902) cellular response to progesterone stimulus(GO:0071393)
1.3 3.8 GO:0030091 protein repair(GO:0030091)
1.2 3.6 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
1.2 5.9 GO:0086100 endothelin receptor signaling pathway(GO:0086100)
1.1 11.0 GO:0006957 complement activation, alternative pathway(GO:0006957)
1.1 6.4 GO:2000304 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
1.0 11.0 GO:0090527 actin filament reorganization(GO:0090527)
1.0 16.0 GO:0043312 neutrophil degranulation(GO:0043312)
1.0 16.3 GO:0000185 activation of MAPKKK activity(GO:0000185)
1.0 3.8 GO:0061373 mammillary body development(GO:0021767) mammillary axonal complex development(GO:0061373)
0.9 4.6 GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045869)
0.8 7.4 GO:0048859 formation of anatomical boundary(GO:0048859)
0.8 5.6 GO:0090403 oxidative stress-induced premature senescence(GO:0090403)
0.8 6.4 GO:0010572 positive regulation of platelet activation(GO:0010572)
0.7 3.5 GO:0008078 mesodermal cell migration(GO:0008078)
0.6 2.4 GO:1900224 zygotic specification of dorsal/ventral axis(GO:0007352) positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.6 6.9 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.6 5.7 GO:0002857 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.6 7.9 GO:0045647 negative regulation of erythrocyte differentiation(GO:0045647)
0.5 5.5 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.5 7.8 GO:0032060 bleb assembly(GO:0032060)
0.4 2.2 GO:2000767 positive regulation of cytoplasmic translation(GO:2000767)
0.4 8.2 GO:2000193 positive regulation of fatty acid transport(GO:2000193)
0.4 1.6 GO:0051464 negative regulation of circadian sleep/wake cycle, REM sleep(GO:0042322) positive regulation of cortisol secretion(GO:0051464)
0.4 2.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.4 1.2 GO:0097010 eukaryotic translation initiation factor 4F complex assembly(GO:0097010)
0.4 10.2 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.3 1.9 GO:0017196 N-terminal peptidyl-methionine acetylation(GO:0017196)
0.3 5.4 GO:0009629 response to gravity(GO:0009629)
0.3 1.5 GO:0003415 chondrocyte hypertrophy(GO:0003415)
0.2 2.5 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.2 1.4 GO:0035735 intraciliary transport involved in cilium morphogenesis(GO:0035735)
0.2 1.6 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.2 2.0 GO:0046884 follicle-stimulating hormone secretion(GO:0046884)
0.2 10.3 GO:0007129 synapsis(GO:0007129)
0.2 1.4 GO:0043951 negative regulation of cAMP-mediated signaling(GO:0043951)
0.2 1.6 GO:0015866 ADP transport(GO:0015866)
0.2 2.0 GO:0031145 anaphase-promoting complex-dependent catabolic process(GO:0031145)
0.1 5.8 GO:0045581 negative regulation of T cell differentiation(GO:0045581)
0.1 1.0 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 1.4 GO:0019720 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.1 1.5 GO:0043508 negative regulation of JUN kinase activity(GO:0043508)
0.1 6.1 GO:0030148 sphingolipid biosynthetic process(GO:0030148)
0.1 5.8 GO:0048662 negative regulation of smooth muscle cell proliferation(GO:0048662)
0.1 2.2 GO:0015985 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 2.5 GO:0045070 positive regulation of viral genome replication(GO:0045070)
0.1 3.8 GO:0043666 regulation of phosphoprotein phosphatase activity(GO:0043666)
0.1 14.6 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.1 3.2 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.1 3.3 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.1 0.7 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.1 18.7 GO:0019221 cytokine-mediated signaling pathway(GO:0019221)
0.0 1.1 GO:0071801 regulation of podosome assembly(GO:0071801)
0.0 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 1.7 GO:0048536 spleen development(GO:0048536)
0.0 2.4 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.4 GO:1900153 regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900151) positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay(GO:1900153)
0.0 0.2 GO:1903054 negative regulation of extracellular matrix organization(GO:1903054)
0.0 1.2 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.1 GO:1905150 regulation of neuronal action potential(GO:0098908) regulation of voltage-gated sodium channel activity(GO:1905150)
0.0 34.6 GO:0006508 proteolysis(GO:0006508)
0.0 3.4 GO:0007018 microtubule-based movement(GO:0007018)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 5.9 GO:0036117 hyaluranon cable(GO:0036117)
1.8 51.8 GO:0042629 mast cell granule(GO:0042629)
1.6 6.4 GO:0031092 platelet alpha granule membrane(GO:0031092)
1.3 7.9 GO:0097209 epidermal lamellar body(GO:0097209)
1.1 9.0 GO:0005658 alpha DNA polymerase:primase complex(GO:0005658)
1.1 5.4 GO:0035976 AP1 complex(GO:0035976)
0.9 16.0 GO:0042581 specific granule(GO:0042581)
0.8 2.4 GO:0070557 PCNA-p21 complex(GO:0070557)
0.6 2.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.5 19.1 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.4 3.3 GO:0001740 Barr body(GO:0001740)
0.3 2.2 GO:0031415 NatA complex(GO:0031415)
0.3 7.8 GO:0043218 compact myelin(GO:0043218)
0.3 2.2 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.3 3.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.2 2.2 GO:0042788 polysomal ribosome(GO:0042788)
0.2 9.6 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 1.2 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.2 7.5 GO:0002102 podosome(GO:0002102)
0.2 22.3 GO:0005923 bicellular tight junction(GO:0005923)
0.1 6.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 11.0 GO:0005884 actin filament(GO:0005884)
0.1 5.4 GO:0030315 T-tubule(GO:0030315)
0.1 14.6 GO:0030018 Z disc(GO:0030018)
0.1 2.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 32.1 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.6 GO:0033391 chromatoid body(GO:0033391)
0.1 2.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 4.6 GO:0032587 ruffle membrane(GO:0032587)
0.1 1.4 GO:0030992 intraciliary transport particle B(GO:0030992)
0.1 18.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 1.6 GO:0016235 aggresome(GO:0016235)
0.0 2.5 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 3.4 GO:0005814 centriole(GO:0005814)
0.0 3.9 GO:0000781 chromosome, telomeric region(GO:0000781)
0.0 2.5 GO:0071013 catalytic step 2 spliceosome(GO:0071013)
0.0 1.2 GO:0034707 chloride channel complex(GO:0034707)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 1.0 GO:0005811 lipid particle(GO:0005811)
0.0 13.4 GO:0005615 extracellular space(GO:0005615)
0.0 3.6 GO:0005667 transcription factor complex(GO:0005667)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 18.9 GO:0004849 uridine kinase activity(GO:0004849)
3.2 16.0 GO:0019834 phospholipase A2 inhibitor activity(GO:0019834)
2.7 16.3 GO:0008349 MAP kinase kinase kinase kinase activity(GO:0008349)
2.1 51.8 GO:0051428 peptide hormone receptor binding(GO:0051428)
2.0 8.1 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
1.8 11.0 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
1.6 6.4 GO:0042806 fucose binding(GO:0042806)
1.5 4.6 GO:0034485 phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
1.3 7.9 GO:0034191 apolipoprotein A-I receptor binding(GO:0034191)
1.3 9.0 GO:0003896 DNA primase activity(GO:0003896)
1.2 6.1 GO:0001729 ceramide kinase activity(GO:0001729)
1.2 5.9 GO:0050501 hyaluronan synthase activity(GO:0050501)
1.2 5.9 GO:0004962 endothelin receptor activity(GO:0004962)
1.0 3.8 GO:0033743 peptide-methionine (R)-S-oxide reductase activity(GO:0033743)
0.8 2.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.8 2.4 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
0.7 18.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.6 2.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618)
0.5 4.2 GO:0071253 connexin binding(GO:0071253)
0.4 8.0 GO:0001618 virus receptor activity(GO:0001618)
0.4 1.6 GO:0016608 growth hormone-releasing hormone activity(GO:0016608)
0.4 1.2 GO:0034057 RNA strand-exchange activity(GO:0034057)
0.4 1.4 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
0.4 10.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.3 14.6 GO:0008307 structural constituent of muscle(GO:0008307)
0.3 9.6 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 63.2 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.2 6.4 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 3.6 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.2 5.4 GO:0070412 R-SMAD binding(GO:0070412)
0.2 18.7 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 1.6 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.2 2.2 GO:0008097 5S rRNA binding(GO:0008097)
0.2 2.2 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 7.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 3.4 GO:0005112 Notch binding(GO:0005112)
0.1 2.5 GO:0001594 trace-amine receptor activity(GO:0001594)
0.1 1.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.1 5.6 GO:0005109 frizzled binding(GO:0005109)
0.1 24.0 GO:0005057 receptor signaling protein activity(GO:0005057)
0.1 3.8 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.1 0.7 GO:0000150 recombinase activity(GO:0000150)
0.1 0.3 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 2.2 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.1 3.3 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.1 12.1 GO:0005179 hormone activity(GO:0005179)
0.1 1.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 5.5 GO:0019838 growth factor binding(GO:0019838)
0.1 2.5 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.1 4.4 GO:0003777 microtubule motor activity(GO:0003777)
0.0 1.6 GO:0046332 SMAD binding(GO:0046332)
0.0 15.4 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.0 23.5 GO:0005198 structural molecule activity(GO:0005198)
0.0 2.4 GO:0019905 syntaxin binding(GO:0019905)
0.0 2.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 1.0 GO:0019003 GDP binding(GO:0019003)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 16.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.7 9.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.7 57.6 PID AP1 PATHWAY AP-1 transcription factor network
0.6 24.0 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.5 6.5 ST STAT3 PATHWAY STAT3 Pathway
0.3 2.4 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.2 15.5 PID E2F PATHWAY E2F transcription factor network
0.2 2.4 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 4.2 ST PHOSPHOINOSITIDE 3 KINASE PATHWAY PI3K Pathway
0.2 7.8 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 6.4 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 6.0 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 18.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 2.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 16.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 5.9 PID ENDOTHELIN PATHWAY Endothelins
0.1 5.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.1 3.0 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 3.4 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 3.3 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.0 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 3.3 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.8 51.8 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.8 11.0 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.7 24.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.7 6.5 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.7 18.9 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
0.6 24.0 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.6 8.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.5 10.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.5 9.0 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.4 7.9 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 5.8 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 9.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.3 5.9 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.3 5.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.2 12.1 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.2 2.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 2.4 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.1 2.2 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.1 4.6 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.0 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
0.1 2.4 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 6.4 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 3.0 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 1.2 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 3.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 5.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 7.5 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 0.3 REACTOME OPSINS Genes involved in Opsins
0.0 1.1 REACTOME KINESINS Genes involved in Kinesins
0.0 1.2 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 1.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 1.0 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis