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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbx1_Eomes

Z-value: 0.67

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Transcription factors associated with Tbx1_Eomes

Gene Symbol Gene ID Gene Info
Tbx1
ENSRNOG00000001892 T-box 1
Eomes
ENSRNOG00000042140 eomesodermin

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Eomesrn6_v1_chr8_+_127144903_1271449030.234.6e-05Click!
Tbx1rn6_v1_chr11_+_86552022_865520220.026.6e-01Click!

Activity profile of Tbx1_Eomes motif

Sorted Z-values of Tbx1_Eomes motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_52350624 53.76 ENSRNOT00000060476
Tmem229a
transmembrane protein 229A
chr5_+_143500441 44.27 ENSRNOT00000045513
Grik3
glutamate ionotropic receptor kainate type subunit 3
chr5_+_164808323 42.18 ENSRNOT00000011005
Nppa
natriuretic peptide A
chrX_-_142248369 41.51 ENSRNOT00000091330
Fgf13
fibroblast growth factor 13
chr5_-_12563429 29.76 ENSRNOT00000059625
St18
suppression of tumorigenicity 18
chr17_-_80320681 27.61 ENSRNOT00000023637
C1ql3
complement C1q like 3
chr2_+_263212051 20.88 ENSRNOT00000089396
Negr1
neuronal growth regulator 1
chr11_-_4397361 18.68 ENSRNOT00000046370
Cadm2
cell adhesion molecule 2
chr5_+_136683592 18.07 ENSRNOT00000085527
Slc6a9
solute carrier family 6 member 9
chr2_+_74360622 18.07 ENSRNOT00000014013
Cdh18
cadherin 18
chr4_-_148845267 17.52 ENSRNOT00000037397
Tmem72
transmembrane protein 72
chr16_+_46731403 16.54 ENSRNOT00000017624
Tenm3
teneurin transmembrane protein 3
chr14_+_12218553 15.56 ENSRNOT00000003237
Prkg2
protein kinase, cGMP-dependent, type II
chr1_+_187149453 14.27 ENSRNOT00000082738
Xylt1
xylosyltransferase 1
chr18_+_46148849 13.78 ENSRNOT00000026724
Prr16
proline rich 16
chr13_-_25262469 13.50 ENSRNOT00000019921
Rnf152
ring finger protein 152
chr10_-_88667345 12.80 ENSRNOT00000025518
Kcnh4
potassium voltage-gated channel subfamily H member 4
chr1_-_165680176 12.43 ENSRNOT00000025245
ENSRNOT00000082697
Plekhb1
pleckstrin homology domain containing B1
chr3_+_161433410 12.38 ENSRNOT00000024657
Slc12a5
solute carrier family 12 member 5
chr10_+_86657285 12.02 ENSRNOT00000087346
Thra
thyroid hormone receptor alpha
chr3_+_131351587 11.92 ENSRNOT00000010835
Btbd3
BTB domain containing 3
chr10_+_85608544 11.84 ENSRNOT00000092122
Mllt6
MLLT6, PHD finger domain containing
chr9_-_63637677 11.57 ENSRNOT00000049259
Satb2
SATB homeobox 2
chr8_+_28352772 9.83 ENSRNOT00000012391
Igsf9b
immunoglobulin superfamily, member 9B
chr6_-_124429701 9.75 ENSRNOT00000037902
ENSRNOT00000080950
Ttc7b
tetratricopeptide repeat domain 7B
chr1_-_226353611 9.57 ENSRNOT00000037624
Dagla
diacylglycerol lipase, alpha
chr13_+_42220251 9.10 ENSRNOT00000078185
AABR07020815.1

chr3_+_100768637 8.78 ENSRNOT00000083542
Bdnf
brain-derived neurotrophic factor
chr1_+_234363994 8.70 ENSRNOT00000018137
Rorb
RAR-related orphan receptor B
chr1_+_88542035 8.56 ENSRNOT00000032973
Zfp420
zinc finger protein 420
chr4_-_180234804 7.99 ENSRNOT00000070957
Bhlhe41
basic helix-loop-helix family, member e41
chr18_+_53609214 7.82 ENSRNOT00000077443
Slc27a6
solute carrier family 27 member 6
chr3_+_160231914 7.39 ENSRNOT00000014411
Kcnk15
potassium two pore domain channel subfamily K member 15
chr4_+_58053041 7.28 ENSRNOT00000072698
Mest
mesoderm specific transcript
chr1_+_79982639 6.80 ENSRNOT00000071916
Dmwd
dystrophia myotonica, WD repeat containing
chr4_+_146455332 6.70 ENSRNOT00000009775
Hrh1
histamine receptor H 1
chr10_-_71383378 6.46 ENSRNOT00000077025
Dusp14
dual specificity phosphatase 14
chr2_-_62634785 6.25 ENSRNOT00000017937
Pdzd2
PDZ domain containing 2
chr8_-_45215974 6.24 ENSRNOT00000010792
Crtam
cytotoxic and regulatory T cell molecule
chr12_-_46920952 4.91 ENSRNOT00000001532
Msi1
musashi RNA-binding protein 1
chr15_+_8739589 4.62 ENSRNOT00000071751
Nr1d2
nuclear receptor subfamily 1, group D, member 2
chr18_-_28871849 4.48 ENSRNOT00000025902
Nrg2
neuregulin 2
chr2_+_140836006 4.47 ENSRNOT00000074141
Dusp14l1
dual specificity phosphatase 14-like 1
chr10_-_74001895 4.08 ENSRNOT00000005658
Vmp1
vacuole membrane protein 1
chr18_-_40134504 3.86 ENSRNOT00000022294
Trim36
tripartite motif-containing 36
chr1_+_224824799 3.86 ENSRNOT00000024757
Slc22a6
solute carrier family 22 member 6
chr13_-_55878094 3.68 ENSRNOT00000014218
Lhx9
LIM homeobox 9
chr10_+_110445797 3.54 ENSRNOT00000054920
Narf
nuclear prelamin A recognition factor
chr6_+_101532518 3.41 ENSRNOT00000075054
Gphn
gephyrin
chr1_+_89017479 3.40 ENSRNOT00000038154
U2af1l4
U2 small nuclear RNA auxiliary factor 1-like 4
chr17_-_14091766 3.32 ENSRNOT00000075373
AABR07027088.1

chr10_-_91186054 3.28 ENSRNOT00000004140
Plcd3
phospholipase C, delta 3
chr8_-_86286991 3.19 ENSRNOT00000046322
LOC367117
similar to RIKEN cDNA 2900055D03
chr10_-_88645364 3.14 ENSRNOT00000030344
Rab5c
RAB5C, member RAS oncogene family
chr1_-_227047290 3.12 ENSRNOT00000037226
Ms4a15
membrane spanning 4-domains A15
chrX_+_16946207 3.08 ENSRNOT00000003981
RGD1563606
similar to cysteine-rich protein 2
chr2_+_207262934 3.07 ENSRNOT00000016833
Ppm1j
protein phosphatase, Mg2+/Mn2+ dependent, 1J
chr7_-_120839577 2.95 ENSRNOT00000018526
Dmc1
DNA meiotic recombinase 1
chr4_+_71675383 2.64 ENSRNOT00000051265
Clcn1
chloride voltage-gated channel 1
chr1_-_172322795 2.58 ENSRNOT00000075318
RGD1562400
similar to olfactory receptor MOR204-14
chr1_+_172822544 2.51 ENSRNOT00000090018
AABR07004960.1

chr12_+_52359310 2.46 ENSRNOT00000071857
ENSRNOT00000065893
Fbrsl1
fibrosin-like 1
chr6_-_44363915 2.42 ENSRNOT00000085925
Id2
inhibitor of DNA binding 2, HLH protein
chr10_-_83104173 2.06 ENSRNOT00000031252
Kat7
lysine acetyltransferase 7
chr3_-_43119159 2.05 ENSRNOT00000041394
Nr4a2
nuclear receptor subfamily 4, group A, member 2
chr8_-_36410612 1.99 ENSRNOT00000091308
Foxred1
FAD-dependent oxidoreductase domain containing 1
chrX_+_70563570 1.90 ENSRNOT00000003772
Gdpd2
glycerophosphodiester phosphodiesterase domain containing 2
chr1_+_150225373 1.81 ENSRNOT00000051266
Olr30
olfactory receptor 30
chr3_+_2490518 1.79 ENSRNOT00000015099
Anapc2
anaphase promoting complex subunit 2
chr8_-_43443531 1.67 ENSRNOT00000007901
LOC103693060
olfactory receptor 148-like
chr5_+_58393603 1.62 ENSRNOT00000080082
Dnajb5
DnaJ heat shock protein family (Hsp40) member B5
chr5_-_819326 1.59 ENSRNOT00000023899
Pi15
peptidase inhibitor 15
chr13_-_90467235 1.49 ENSRNOT00000081534
ENSRNOT00000008150
Ncstn
nicastrin
chr1_+_85485289 1.43 ENSRNOT00000026182
Dll3
delta like canonical Notch ligand 3
chrX_+_128897181 1.42 ENSRNOT00000008444
Sh2d1a
SH2 domain containing 1A
chr7_+_43601513 1.29 ENSRNOT00000030321
AABR07056845.1

chr7_-_27240528 1.29 ENSRNOT00000029435
ENSRNOT00000079731
Hsp90b1
heat shock protein 90 beta family member 1
chr11_+_43143882 1.19 ENSRNOT00000041445
Olr1528
olfactory receptor 1528
chr10_-_86393141 1.05 ENSRNOT00000009485
Mien1
migration and invasion enhancer 1
chr1_+_7252349 0.86 ENSRNOT00000030329
Plagl1
PLAG1 like zinc finger 1
chrM_+_7758 0.85 ENSRNOT00000046201
Mt-atp8
mitochondrially encoded ATP synthase 8
chr19_+_39126589 0.85 ENSRNOT00000027561
Sntb2
syntrophin, beta 2
chrM_+_7919 0.63 ENSRNOT00000046108
Mt-atp6
mitochondrially encoded ATP synthase 6
chr9_-_15700235 0.57 ENSRNOT00000088713
ENSRNOT00000035907
Trerf1
transcriptional regulating factor 1
chr5_+_156587093 0.57 ENSRNOT00000019696
Hp1bp3
heterochromatin protein 1, binding protein 3
chr1_+_172051215 0.55 ENSRNOT00000048370
Olr235
olfactory receptor 235
chr4_+_57034675 0.51 ENSRNOT00000080223
Smo
smoothened, frizzled class receptor
chr5_+_63781801 0.45 ENSRNOT00000008302
Nr4a3
nuclear receptor subfamily 4, group A, member 3
chr1_-_124803363 0.45 ENSRNOT00000066380
Klf13
Kruppel-like factor 13
chr8_+_41936959 0.44 ENSRNOT00000042601
Olr1222
olfactory receptor 1222
chr6_-_50923510 0.37 ENSRNOT00000010631
Bcap29
B-cell receptor-associated protein 29
chr1_+_282557426 0.32 ENSRNOT00000088966
AABR07007134.1

chr11_-_45616429 0.22 ENSRNOT00000046587
Olr1533
olfactory receptor 1533

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbx1_Eomes

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
14.1 42.2 GO:1902304 positive regulation of potassium ion export(GO:1902304)
5.9 41.5 GO:0045200 establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200)
5.2 15.6 GO:2001226 negative regulation of chloride transport(GO:2001226)
4.0 44.3 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
4.0 12.0 GO:0017055 negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055)
3.9 11.8 GO:2001160 regulation of histone H3-K79 methylation(GO:2001160)
3.2 9.6 GO:0046340 diacylglycerol catabolic process(GO:0046340) trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542)
2.2 6.7 GO:0007199 G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger(GO:0007199)
1.8 12.8 GO:0000160 phosphorelay signal transduction system(GO:0000160)
1.6 18.1 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
1.5 16.5 GO:0097264 self proteolysis(GO:0097264)
1.4 12.4 GO:0030644 cellular chloride ion homeostasis(GO:0030644)
1.2 3.7 GO:0035262 gonad morphogenesis(GO:0035262)
1.2 14.3 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
1.1 8.8 GO:0061193 taste bud development(GO:0061193)
1.1 11.6 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.9 3.4 GO:0097112 establishment of synaptic specificity at neuromuscular junction(GO:0007529) gamma-aminobutyric acid receptor clustering(GO:0097112)
0.8 2.4 GO:0001966 thigmotaxis(GO:0001966)
0.8 3.9 GO:0031427 response to methotrexate(GO:0031427)
0.7 8.0 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.7 8.7 GO:0046549 amacrine cell differentiation(GO:0035881) retinal rod cell development(GO:0046548) retinal cone cell development(GO:0046549)
0.7 2.1 GO:0072720 response to dithiothreitol(GO:0072720)
0.7 2.1 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.6 6.2 GO:0002860 positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.6 9.8 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151)
0.6 13.8 GO:0045793 positive regulation of cell size(GO:0045793)
0.4 3.1 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.4 3.0 GO:0042148 strand invasion(GO:0042148)
0.4 1.4 GO:0007386 compartment pattern specification(GO:0007386)
0.3 13.5 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.3 36.7 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.2 9.8 GO:0046854 phosphatidylinositol phosphorylation(GO:0046854)
0.2 4.6 GO:2001014 regulation of skeletal muscle cell differentiation(GO:2001014)
0.2 2.6 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.2 29.4 GO:0050807 regulation of synapse organization(GO:0050807)
0.2 0.6 GO:0097298 regulation of nucleus size(GO:0097298)
0.2 4.6 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.2 1.9 GO:0090527 actin filament reorganization(GO:0090527)
0.1 7.3 GO:0010883 regulation of lipid storage(GO:0010883)
0.1 17.8 GO:0007631 feeding behavior(GO:0007631)
0.1 1.3 GO:0071318 cellular response to ATP(GO:0071318)
0.1 0.5 GO:0007228 positive regulation of hh target transcription factor activity(GO:0007228)
0.1 3.3 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 1.4 GO:0006968 cellular defense response(GO:0006968)
0.1 2.0 GO:0010257 NADH dehydrogenase complex assembly(GO:0010257) mitochondrial respiratory chain complex I assembly(GO:0032981) mitochondrial respiratory chain complex I biogenesis(GO:0097031)
0.1 3.9 GO:0007340 acrosome reaction(GO:0007340)
0.1 7.8 GO:0015908 fatty acid transport(GO:0015908)
0.1 0.8 GO:0007220 Notch receptor processing(GO:0007220)
0.1 11.9 GO:0021987 cerebral cortex development(GO:0021987)
0.1 4.1 GO:0007566 embryo implantation(GO:0007566)
0.1 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.1 6.8 GO:0016579 protein deubiquitination(GO:0016579)
0.1 1.5 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.1 4.5 GO:0007173 epidermal growth factor receptor signaling pathway(GO:0007173)
0.0 1.1 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 7.4 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 20.8 GO:0000122 negative regulation of transcription from RNA polymerase II promoter(GO:0000122)
0.0 3.3 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 42.6 GO:0042629 mast cell granule(GO:0042629)
1.3 44.3 GO:0032839 dendrite cytoplasm(GO:0032839)
0.7 3.4 GO:0089701 U2AF(GO:0089701)
0.6 41.5 GO:0016328 lateral plasma membrane(GO:0016328)
0.5 8.8 GO:0030061 mitochondrial crista(GO:0030061)
0.5 9.6 GO:0043196 varicosity(GO:0043196)
0.5 18.7 GO:0032809 neuronal cell body membrane(GO:0032809)
0.4 3.5 GO:0005638 lamin filament(GO:0005638)
0.4 12.4 GO:0032590 dendrite membrane(GO:0032590)
0.4 13.2 GO:0060077 inhibitory synapse(GO:0060077)
0.2 20.9 GO:0031225 anchored component of membrane(GO:0031225)
0.2 11.9 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.2 11.8 GO:0005581 collagen trimer(GO:0005581)
0.2 12.1 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 4.1 GO:0000407 pre-autophagosomal structure(GO:0000407) autophagosome membrane(GO:0000421)
0.1 0.8 GO:0070765 gamma-secretase complex(GO:0070765)
0.1 1.3 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.1 1.5 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.1 1.8 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 1.1 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 16.6 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 4.4 GO:0005901 caveola(GO:0005901)
0.1 6.2 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 2.6 GO:0034707 chloride channel complex(GO:0034707)
0.1 18.1 GO:0098793 presynapse(GO:0098793)
0.0 21.4 GO:0045177 apical part of cell(GO:0045177)
0.0 2.0 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.0 14.3 GO:0000139 Golgi membrane(GO:0000139)
0.0 3.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 3.0 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 129.5 GO:0016021 integral component of membrane(GO:0016021)
0.0 2.1 GO:0000123 histone acetyltransferase complex(GO:0000123)
0.0 1.0 GO:0005844 polysome(GO:0005844)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.3 44.3 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
4.8 14.3 GO:0030158 protein xylosyltransferase activity(GO:0030158)
3.1 15.6 GO:0004690 cyclic nucleotide-dependent protein kinase activity(GO:0004690)
1.8 12.8 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
1.7 8.7 GO:0008502 melatonin receptor activity(GO:0008502)
1.7 42.2 GO:0051428 peptide hormone receptor binding(GO:0051428)
1.5 16.6 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.4 18.1 GO:0015187 sodium:amino acid symporter activity(GO:0005283) glycine transmembrane transporter activity(GO:0015187)
1.3 6.7 GO:0004969 histamine receptor activity(GO:0004969)
1.1 8.0 GO:0043426 MRF binding(GO:0043426)
1.1 4.5 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
1.1 8.8 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.0 12.4 GO:0022820 potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820)
0.9 41.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.9 3.4 GO:0008940 nitrate reductase activity(GO:0008940)
0.8 7.8 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.5 3.0 GO:0000150 recombinase activity(GO:0000150)
0.5 3.9 GO:0031404 chloride ion binding(GO:0031404)
0.3 3.4 GO:0030628 pre-mRNA 3'-splice site binding(GO:0030628)
0.3 1.9 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.3 4.6 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.2 4.9 GO:0008266 poly(U) RNA binding(GO:0008266)
0.2 3.5 GO:0005521 lamin binding(GO:0005521)
0.2 3.3 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.1 2.1 GO:0003688 DNA replication origin binding(GO:0003688)
0.1 1.3 GO:0046790 virion binding(GO:0046790)
0.1 2.6 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.1 1.4 GO:0005112 Notch binding(GO:0005112)
0.1 15.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 0.5 GO:0005113 patched binding(GO:0005113)
0.1 1.4 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 52.2 GO:0042803 protein homodimerization activity(GO:0042803)
0.1 7.4 GO:0005267 potassium channel activity(GO:0005267)
0.1 3.1 GO:0019003 GDP binding(GO:0019003)
0.0 3.1 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 1.7 GO:0004879 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 18.1 GO:0005509 calcium ion binding(GO:0005509)
0.0 2.4 GO:0044325 ion channel binding(GO:0044325)
0.0 23.8 GO:0008270 zinc ion binding(GO:0008270)
0.0 1.6 GO:0051087 chaperone binding(GO:0051087)
0.0 5.2 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 1.5 GO:0015078 hydrogen ion transmembrane transporter activity(GO:0015078)
0.0 0.6 GO:0031491 nucleosome binding(GO:0031491)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 42.2 PID AP1 PATHWAY AP-1 transcription factor network
0.2 10.2 PID RXR VDR PATHWAY RXR and RAR heterodimerization with other nuclear receptor
0.2 4.5 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 9.6 PID NCADHERIN PATHWAY N-cadherin signaling events
0.2 27.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 10.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.2 8.8 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 29.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.1 0.8 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 2.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.3 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.4 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.5 ST GA12 PATHWAY G alpha 12 Pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.8 44.3 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
1.7 15.6 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
1.5 42.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
1.3 36.7 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.8 18.1 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.4 27.5 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.4 3.9 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.4 8.0 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.3 9.6 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.3 4.5 REACTOME DOWNREGULATION OF ERBB2 ERBB3 SIGNALING Genes involved in Downregulation of ERBB2:ERBB3 signaling
0.2 12.8 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 7.8 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.2 6.7 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 6.2 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 1.3 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 12.4 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 1.8 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.1 0.8 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.1 3.4 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.1 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 3.0 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.0 3.9 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation