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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Tbx15
Z-value: 0.80
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Transcription factors associated with Tbx15
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Tbx15 | rn6_v1_chr2_+_201289357_201289357 | 0.02 | 6.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr18_+_53609214 Show fit | 70.85 |
ENSRNOT00000077443
|
solute carrier family 27 member 6 |
|
| chr4_-_148845267 Show fit | 28.44 |
ENSRNOT00000037397
|
transmembrane protein 72 |
|
| chr3_+_61620192 Show fit | 21.01 |
ENSRNOT00000065426
|
homeo box D9 |
|
| chr2_-_23289266 Show fit | 19.57 |
ENSRNOT00000061708
|
betaine-homocysteine S-methyltransferase 2 |
|
| chr1_+_7252349 Show fit | 17.31 |
ENSRNOT00000030329
|
PLAG1 like zinc finger 1 |
|
| chr2_+_60920257 Show fit | 13.46 |
ENSRNOT00000025170
|
C1q and tumor necrosis factor related protein 3 |
|
| chr11_-_81717521 Show fit | 12.45 |
ENSRNOT00000058422
|
alpha-2-HS-glycoprotein |
|
| chr6_-_127653124 Show fit | 11.32 |
ENSRNOT00000047324
|
serpin family A member 11 |
|
| chr8_-_78233430 Show fit | 10.79 |
ENSRNOT00000083220
|
cingulin-like 1 |
|
| chrX_-_142248369 Show fit | 10.77 |
ENSRNOT00000091330
|
fibroblast growth factor 13 |
Network of associatons between targets according to the STRING database.
First level regulatory network of Tbx15
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 68.5 | GO:0001676 | long-chain fatty acid metabolic process(GO:0001676) |
| 0.0 | 22.4 | GO:0050911 | detection of chemical stimulus involved in sensory perception of smell(GO:0050911) |
| 1.8 | 21.0 | GO:0048935 | peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935) |
| 2.4 | 19.6 | GO:0071267 | amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267) |
| 0.2 | 16.7 | GO:0035914 | skeletal muscle cell differentiation(GO:0035914) |
| 2.1 | 16.6 | GO:0070163 | adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163) |
| 0.8 | 12.5 | GO:1904262 | negative regulation of TORC1 signaling(GO:1904262) |
| 0.5 | 12.4 | GO:0046852 | negative regulation of bone mineralization(GO:0030502) positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
| 1.5 | 10.8 | GO:0045196 | establishment or maintenance of neuroblast polarity(GO:0045196) establishment of neuroblast polarity(GO:0045200) |
| 1.8 | 10.7 | GO:0031427 | response to methotrexate(GO:0031427) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 29.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.1 | 15.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.0 | 13.1 | GO:0016604 | nuclear body(GO:0016604) |
| 0.1 | 12.2 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.0 | 11.6 | GO:0031301 | integral component of organelle membrane(GO:0031301) |
| 0.2 | 10.8 | GO:0016459 | myosin complex(GO:0016459) |
| 0.1 | 10.7 | GO:0005901 | caveola(GO:0005901) |
| 0.1 | 9.4 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.1 | 9.0 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.7 | 8.8 | GO:0005859 | muscle myosin complex(GO:0005859) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.1 | 70.9 | GO:0031957 | very long-chain fatty acid-CoA ligase activity(GO:0031957) |
| 0.0 | 22.4 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 2.4 | 19.6 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.1 | 16.3 | GO:0003774 | motor activity(GO:0003774) |
| 3.1 | 12.3 | GO:0030294 | receptor signaling protein tyrosine kinase inhibitor activity(GO:0030294) |
| 1.5 | 12.1 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.1 | 12.1 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 3.6 | 10.7 | GO:0003941 | L-serine ammonia-lyase activity(GO:0003941) |
| 1.3 | 10.7 | GO:0031404 | chloride ion binding(GO:0031404) |
| 2.1 | 10.6 | GO:0004690 | cyclic nucleotide-dependent protein kinase activity(GO:0004690) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.4 | PID BMP PATHWAY | BMP receptor signaling |
| 0.1 | 8.8 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.0 | 7.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 5.4 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.2 | 4.9 | PID ARF 3PATHWAY | Arf1 pathway |
| 0.1 | 4.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 4.0 | ST WNT BETA CATENIN PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 4.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.0 | 3.9 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.2 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 66.8 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 1.9 | 21.2 | REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT | Genes involved in Organic cation/anion/zwitterion transport |
| 1.5 | 12.4 | REACTOME ETHANOL OXIDATION | Genes involved in Ethanol oxidation |
| 0.9 | 10.6 | REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION | Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation |
| 0.5 | 9.3 | REACTOME HS GAG DEGRADATION | Genes involved in HS-GAG degradation |
| 0.2 | 8.8 | REACTOME STRIATED MUSCLE CONTRACTION | Genes involved in Striated Muscle Contraction |
| 0.1 | 7.5 | REACTOME MEIOTIC RECOMBINATION | Genes involved in Meiotic Recombination |
| 0.2 | 6.9 | REACTOME SULFUR AMINO ACID METABOLISM | Genes involved in Sulfur amino acid metabolism |
| 0.9 | 5.7 | REACTOME DIGESTION OF DIETARY CARBOHYDRATE | Genes involved in Digestion of dietary carbohydrate |
| 0.3 | 5.4 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |