ISMARA results: Tbr1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tbr1

Z-value: 1.00

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Transcription factors associated with Tbr1

Gene Symbol	Gene ID	Gene Info
Tbr1 NCBI RGD Ensembl	ENSRNOG00000005049	T-box, brain, 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tbr1	rn6_v1_chr3_+_47677720_47677720	-0.14	1.3e-02	Click!

Activity profile of Tbr1 motif

Sorted Z-values of Tbr1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr11_+_74057361 Show fit	41.06	ENSRNOT00000048746	Cpn2 NCBI RGD Ensembl Show fit	carboxypeptidase N subunit 2
chrX_-_1848904 Show fit	37.76	ENSRNOT00000010984	Rgn NCBI RGD Ensembl Show fit	regucalcin
chr1_+_48273611 Show fit	35.49	ENSRNOT00000022254 ENSRNOT00000022068	Slc22a1 NCBI RGD Ensembl Show fit	solute carrier family 22 member 1
chr2_-_23289266 Show fit	32.56	ENSRNOT00000061708	Bhmt2 NCBI RGD Ensembl Show fit	betaine-homocysteine S-methyltransferase 2
chr9_+_4072823 Show fit	31.96	ENSRNOT00000085330 ENSRNOT00000061864	LOC100910057 NCBI RGD Ensembl Show fit	sulfotransferase 1C2-like
chr1_+_148240504 Show fit	31.64	ENSRNOT00000085373	LOC100361547 NCBI RGD Ensembl Show fit	Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr7_+_34326087 Show fit	30.96	ENSRNOT00000006971	Hal NCBI RGD Ensembl Show fit	histidine ammonia lyase
chr15_+_57290849 Show fit	30.61	ENSRNOT00000014909	Cpb2 NCBI RGD Ensembl Show fit	carboxypeptidase B2
chr11_-_81444375 Show fit	30.11	ENSRNOT00000058479 ENSRNOT00000078131 ENSRNOT00000080949 ENSRNOT00000080562 ENSRNOT00000084867	Kng1 NCBI RGD Ensembl Show fit	kininogen 1
chr9_-_4683160 Show fit	28.45	ENSRNOT00000081413	Sult1c2 NCBI RGD Ensembl Show fit	sulfotransferase family 1C member 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	118.3	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
3.0	82.3	GO:0019373	epoxygenase P450 pathway(GO:0019373)
3.9	61.7	GO:0051923	sulfation(GO:0051923)
0.2	47.4	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
4.0	40.0	GO:0015697	quaternary ammonium group transport(GO:0015697)
12.6	37.8	GO:1903630	regulation of aminoacyl-tRNA ligase activity(GO:1903630)
0.9	33.0	GO:0042311	vasodilation(GO:0042311)
1.2	32.7	GO:0001580	detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
4.1	32.6	GO:0043102	amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
5.3	31.8	GO:0006572	tyrosine catabolic process(GO:0006572)

Showing 1 to 10 of 368 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	145.0	GO:0005615	extracellular space(GO:0005615)
0.8	90.7	GO:0072562	blood microparticle(GO:0072562)
0.1	72.5	GO:0005739	mitochondrion(GO:0005739)
0.4	59.0	GO:0001669	acrosomal vesicle(GO:0001669)
0.2	54.0	GO:0005759	mitochondrial matrix(GO:0005759)
0.4	53.9	GO:0042579	peroxisome(GO:0005777) microbody(GO:0042579)
0.1	51.3	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.1	41.3	GO:0005764	lytic vacuole(GO:0000323) lysosome(GO:0005764)
1.9	38.9	GO:0031907	peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1	29.7	GO:0005743	mitochondrial inner membrane(GO:0005743)

Showing 1 to 10 of 123 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.0	118.5	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
2.2	86.8	GO:0004364	glutathione transferase activity(GO:0004364)
2.7	82.3	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
1.4	74.3	GO:0008146	sulfotransferase activity(GO:0008146)
0.2	73.7	GO:0005549	odorant binding(GO:0005549)
12.6	62.9	GO:0005550	pheromone binding(GO:0005550)
1.9	59.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
9.7	48.7	GO:0016841	ammonia-lyase activity(GO:0016841)
0.2	47.9	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.1	44.5	GO:0004984	olfactory receptor activity(GO:0004984)

Showing 1 to 10 of 257 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.9	209.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8	44.4	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.4	12.8	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
0.5	11.9	PID RHODOPSIN PATHWAY	Visual signal transduction: Rods
0.2	10.8	NABA COLLAGENS	Genes encoding collagen proteins
0.2	8.0	PID NECTIN PATHWAY	Nectin adhesion pathway
0.3	7.5	PID FGF PATHWAY	FGF signaling pathway
0.4	7.2	PID ERBB NETWORK PATHWAY	ErbB receptor signaling network
0.2	6.8	PID WNT SIGNALING PATHWAY	Wnt signaling network
0.3	6.6	PID ALPHA SYNUCLEIN PATHWAY	Alpha-synuclein signaling

Showing 1 to 10 of 39 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.7	130.3	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
5.0	65.4	REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES	Genes involved in Cytosolic sulfonation of small molecules
5.3	47.6	REACTOME TRYPTOPHAN CATABOLISM	Genes involved in Tryptophan catabolism
2.3	42.8	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
4.4	40.0	REACTOME ABACAVIR TRANSPORT AND METABOLISM	Genes involved in Abacavir transport and metabolism
3.0	36.4	REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL	Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
2.0	33.8	REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT	Genes involved in Chylomicron-mediated lipid transport
1.6	28.3	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.3	27.1	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.9	24.2	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells

Showing 1 to 10 of 92 entries

Results for Tbr1

Z-value: 1.00

Motif logo

Transcription factors associated with Tbr1

Activity-expression correlation:

Activity profile of Tbr1 motif

Sorted Z-values of Tbr1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tbr1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: