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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tal1

Z-value: 1.49

Motif logo

Transcription factors associated with Tal1

Gene Symbol Gene ID Gene Info
ENSRNOG00000025051 TAL bHLH transcription factor 1, erythroid differentiation factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Tal1rn6_v1_chr5_+_133864798_1338647980.534.8e-25Click!

Activity profile of Tal1 motif

Sorted Z-values of Tal1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_151172206 89.06 ENSRNOT00000013778
FGR proto-oncogene, Src family tyrosine kinase
chr4_+_70614524 64.35 ENSRNOT00000041100
protease, serine 3
chr20_-_5806097 62.92 ENSRNOT00000000611
colipase
chr1_+_279798187 61.23 ENSRNOT00000024065
pancreatic lipase
chr4_+_70689737 58.17 ENSRNOT00000018852
protease, serine, 2
chr9_-_23493081 56.81 ENSRNOT00000072144
Rh-associated glycoprotein
chr1_+_279867034 53.34 ENSRNOT00000024164
pancreatic lipase-related protein 1
chr20_-_2191640 52.58 ENSRNOT00000001016
tripartite motif-containing 10
chr10_-_90415070 49.75 ENSRNOT00000055179
integrin subunit alpha 2b
chr10_-_15590220 49.65 ENSRNOT00000048977
hemoglobin alpha, adult chain 2
chr1_+_279896973 48.50 ENSRNOT00000068119
pancreatic lipase related protein 2
chr4_+_57855416 47.12 ENSRNOT00000029608
carboxypeptidase A2
chrX_-_23187341 47.08 ENSRNOT00000000180
5'-aminolevulinate synthase 2
chr7_+_121841855 43.01 ENSRNOT00000024673
GRB2-related adaptor protein 2
chr4_+_117744075 40.27 ENSRNOT00000081173
adducin 2
chr4_+_101645731 40.19 ENSRNOT00000087901

chr4_+_117743710 39.20 ENSRNOT00000021491
adducin 2
chr4_-_103050006 38.95 ENSRNOT00000092130
uncharacterized LOC100911032
chr1_+_73040901 38.07 ENSRNOT00000071927
glycoprotein 6 (platelet)
chr11_-_44049648 37.81 ENSRNOT00000002257
coproporphyrinogen oxidase
chr4_-_70747226 36.71 ENSRNOT00000044960
anionic trypsin-2-like
chr8_+_22047697 36.08 ENSRNOT00000067741
intercellular adhesion molecule 4, Landsteiner-Wiener blood group
chr16_+_75572070 35.54 ENSRNOT00000043486
defensin beta 52
chr10_-_15603649 34.32 ENSRNOT00000051483
hemoglobin alpha, adult chain 2
chr17_-_31706523 34.17 ENSRNOT00000071312

chr2_+_190073815 33.41 ENSRNOT00000015473
S100 calcium binding protein A8
chr14_+_22517774 33.36 ENSRNOT00000047655
UDP-glucuronosyltransferase 2 family, member 37
chr2_+_188449210 31.84 ENSRNOT00000027700
pyruvate kinase, liver and RBC
chr10_+_106785077 30.66 ENSRNOT00000075047
transmembrane channel-like 8
chr15_-_28217614 29.10 ENSRNOT00000040857
ribonuclease A family member 3
chr13_-_77896697 28.95 ENSRNOT00000003452
tenascin N
chr2_-_173668555 27.75 ENSRNOT00000013452
serpin family I member 2
chr3_+_17889972 26.14 ENSRNOT00000073021

chr13_+_83972212 25.97 ENSRNOT00000004394
cellular repressor of E1A-stimulated genes 1
chr17_-_31780120 25.67 ENSRNOT00000058388

chr15_-_28241198 25.09 ENSRNOT00000086535
eosinophil cationic protein-like
chr10_+_70417108 24.66 ENSRNOT00000079325
schlafen 4
chr16_-_19918644 24.41 ENSRNOT00000083345
ENSRNOT00000023926
plasmalemma vesicle associated protein
chr10_+_70411738 24.12 ENSRNOT00000078046
schlafen 4
chr11_+_85561460 23.58 ENSRNOT00000075455

chr3_-_48372583 22.95 ENSRNOT00000040482
ENSRNOT00000077788
ENSRNOT00000085426
dipeptidylpeptidase 4
chr10_-_110232843 22.92 ENSRNOT00000054934
Cd7 molecule
chr19_+_25815207 22.91 ENSRNOT00000003980
LYL1, basic helix-loop-helix family member
chr4_+_102351036 22.33 ENSRNOT00000079277

chr5_+_153197459 21.71 ENSRNOT00000023187
Rh blood group, D antigen
chr4_-_103115522 21.34 ENSRNOT00000074206

chr4_-_102124609 20.94 ENSRNOT00000048263

chr5_+_133864798 20.77 ENSRNOT00000091977
TAL bHLH transcription factor 1, erythroid differentiation factor
chr4_-_103331319 19.61 ENSRNOT00000086338

chr11_+_85618714 19.48 ENSRNOT00000074614

chr1_-_98570949 19.42 ENSRNOT00000033648
sialic acid binding Ig-like lectin 5
chr15_-_28204691 19.34 ENSRNOT00000048941
ribonuclease 17
chr8_-_119326938 19.34 ENSRNOT00000044467
C-C motif chemokine receptor like 2
chr1_+_227640680 19.03 ENSRNOT00000033613
membrane-spanning 4-domains, subfamily A, member 4C
chr7_-_101138860 18.40 ENSRNOT00000077137

chr3_+_119561290 18.37 ENSRNOT00000015843
biliverdin reductase A
chr1_-_148119857 18.36 ENSRNOT00000040325
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr7_+_118685181 18.31 ENSRNOT00000068221
apolipoprotein L, 3
chr15_-_52399074 18.09 ENSRNOT00000018440
exportin 7
chr20_+_9948908 18.00 ENSRNOT00000001541
ubiquitin associated and SH3 domain containing, A
chr15_+_57221292 17.88 ENSRNOT00000014502
lymphocyte cytosolic protein 1
chr14_+_44889287 17.79 ENSRNOT00000091312
ENSRNOT00000032273
transmembrane protein 156
chr6_+_128050250 17.54 ENSRNOT00000077517
ENSRNOT00000013961
Ab1-233
chr7_+_138707426 17.53 ENSRNOT00000037874
PC-esterase domain containing 1B
chr4_+_14070553 16.87 ENSRNOT00000077505
CD36 molecule
chr1_+_189359853 16.83 ENSRNOT00000055083
acyl-CoA synthetase medium-chain family member 1
chr15_+_28260411 16.51 ENSRNOT00000021645
eosinophil-associated, ribonuclease A family, member 1
chr8_-_22974321 16.51 ENSRNOT00000017369
erythropoietin receptor
chr7_+_118685022 16.37 ENSRNOT00000089135
apolipoprotein L, 3
chr7_-_115994783 16.30 ENSRNOT00000036268
lymphocyte antigen 6 complex, locus D
chr14_-_84189266 16.26 ENSRNOT00000005934
transcobalamin 2
chr2_-_187909394 16.18 ENSRNOT00000032355
RAB25, member RAS oncogene family
chrX_-_135250519 16.18 ENSRNOT00000044487
E74 like ETS transcription factor 4
chr8_-_33661049 15.77 ENSRNOT00000068037
Fli-1 proto-oncogene, ETS transcription factor
chr5_+_48303366 15.49 ENSRNOT00000009973
gamma-aminobutyric acid type A receptor rho 2 subunit
chr18_+_86299463 15.39 ENSRNOT00000058152
CD226 molecule
chr4_-_165541314 15.29 ENSRNOT00000013833
serine/threonine/tyrosine kinase 1
chr4_+_102643934 15.22 ENSRNOT00000058389
uncharacterized LOC100911032
chr3_+_19366370 14.60 ENSRNOT00000086557

chr4_-_165195489 14.60 ENSRNOT00000079429
killer cell lectin-like receptor, subfamily A, member 5
chr1_-_258877045 13.87 ENSRNOT00000071633
cytochrome P450, family 2, subfamily c, polypeptide 13
chr18_-_25314047 13.70 ENSRNOT00000079778

chr8_-_71728654 13.02 ENSRNOT00000031207
ENSRNOT00000091751
sorting nexin 22
chr6_-_142178771 12.90 ENSRNOT00000071577
immunoglobulin heavy variable V12-3
chr12_-_45116665 12.55 ENSRNOT00000089043
TAO kinase 3
chr5_-_160423811 12.51 ENSRNOT00000018864
EF-hand domain family, member D2
chr1_+_214454090 12.47 ENSRNOT00000049448
tetraspanin 4
chr8_-_48672732 12.03 ENSRNOT00000079275
hydroxymethylbilane synthase
chr18_+_44716226 11.92 ENSRNOT00000086431
TNF alpha induced protein 8
chr3_-_72171078 11.82 ENSRNOT00000009817
serpin family G member 1
chr13_-_83202864 11.79 ENSRNOT00000003976
X-C motif chemokine ligand 1
chr1_+_81499821 11.74 ENSRNOT00000027100
Ly6/Plaur domain containing 3
chr17_-_43821536 11.71 ENSRNOT00000072286
histone H4 variant H4-v.1
chr16_+_10267482 11.35 ENSRNOT00000085255
growth differentiation factor 2
chr2_+_178679041 11.14 ENSRNOT00000013524
family with sequence similarity 198, member B
chr4_+_102290338 10.96 ENSRNOT00000011067

chr2_+_212257225 10.87 ENSRNOT00000077883
vav guanine nucleotide exchange factor 3
chrX_-_13279082 10.77 ENSRNOT00000051898
ENSRNOT00000060857
tetraspanin 7
chr17_+_81352700 10.75 ENSRNOT00000024736
mannose receptor, C type 1
chr1_+_282265370 10.61 ENSRNOT00000015687
G protein-coupled receptor kinase 5
chr16_-_10706073 10.54 ENSRNOT00000089114
family with sequence similarity 25, member A
chr1_+_72784966 10.49 ENSRNOT00000090065
ENSRNOT00000041527
transmembrane protein 86B
chr4_-_103569159 10.29 ENSRNOT00000084036

chr18_-_74485139 10.15 ENSRNOT00000022598
solute carrier family 14 member 1
chr2_-_193330699 10.02 ENSRNOT00000012684
cysteine-rich C-terminal 1
chr11_-_80981415 9.74 ENSRNOT00000002499
ENSRNOT00000002496
ST6 beta-galactoside alpha-2,6-sialyltransferase 1
chr15_+_57290849 9.74 ENSRNOT00000014909
carboxypeptidase B2
chr4_+_155088317 9.43 ENSRNOT00000088728
mannose-6-phosphate receptor, cation dependent
chr5_-_76632462 9.35 ENSRNOT00000085109
sushi domain containing 1
chr15_+_34234755 9.29 ENSRNOT00000059987
DDB1 and CUL4 associated factor 11
chr9_+_98438439 9.29 ENSRNOT00000027220
selenocysteine lyase
chr1_+_260732485 9.27 ENSRNOT00000076842
ENSRNOT00000076073
ligand dependent nuclear receptor corepressor
chr15_-_28155291 9.17 ENSRNOT00000050820
ribonuclease A family member 2
chr3_+_5519990 8.87 ENSRNOT00000070873
ENSRNOT00000007640
ADAM metallopeptidase with thrombospondin type 1 motif, 13
chr2_+_226563050 8.85 ENSRNOT00000065111
breast cancer anti-estrogen resistance 3
chr10_+_105630810 8.82 ENSRNOT00000064904
photoreceptor disc component
chr11_+_85030872 8.79 ENSRNOT00000074815
olfactory receptor 2L3-like
chr7_+_3216497 8.56 ENSRNOT00000008909
matrix metallopeptidase 19
chr9_-_26707571 8.47 ENSRNOT00000080948

chr12_+_40244081 8.45 ENSRNOT00000030583
SH2B adaptor protein 3
chr14_-_44225713 8.22 ENSRNOT00000049161
similar to ribosomal protein L14
chr2_+_178679395 7.93 ENSRNOT00000088686
family with sequence similarity 198, member B
chr3_-_148722710 7.73 ENSRNOT00000090919
ENSRNOT00000068592
PLAG1 like zinc finger 2
chr11_+_31640407 7.66 ENSRNOT00000029985
ENSRNOT00000091472
interferon alpha and beta receptor subunit 1
chr7_-_116504853 7.51 ENSRNOT00000056557
similar to Ly6-C antigen gene
chr7_-_11444786 7.47 ENSRNOT00000027323
zinc finger and BTB domain containing 7a
chr8_+_64088913 7.26 ENSRNOT00000013022
ADP-dependent glucokinase
chr19_-_838099 7.12 ENSRNOT00000014234
CKLF-like MARVEL transmembrane domain containing 3
chr1_-_221370322 7.07 ENSRNOT00000028431
calpain 1
chr8_+_96564877 6.87 ENSRNOT00000017879
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)
chrX_-_135342996 6.83 ENSRNOT00000084848
ENSRNOT00000008503
apoptosis inducing factor, mitochondria associated 1
chr3_-_123702732 6.56 ENSRNOT00000028859
similar to RIKEN cDNA 1700037H04
chr10_-_34961608 6.55 ENSRNOT00000033056
heterogeneous nuclear ribonucleoprotein A/B
chr5_-_115222075 6.53 ENSRNOT00000058163
ENSRNOT00000012503
cytochrome P450 2J3-like
chr1_+_165482155 6.49 ENSRNOT00000024005
uncoupling protein 3
chr1_-_80178708 6.45 ENSRNOT00000088676
vasodilator-stimulated phosphoprotein
chr14_+_43810119 6.38 ENSRNOT00000003327
RNA binding motif protein 47
chr13_-_36290531 6.38 ENSRNOT00000071388
STEAP3 metalloreductase
chr3_-_123236535 6.17 ENSRNOT00000028839
solute carrier family 4 member 11
chr1_+_214016897 6.13 ENSRNOT00000075588
tetraspanin-4-like
chr19_-_43528851 6.10 ENSRNOT00000036972
mixed lineage kinase domain like pseudokinase
chr12_+_48403797 6.01 ENSRNOT00000044751
slingshot protein phosphatase 1
chr20_-_2211995 5.99 ENSRNOT00000077201
tripartite motif-containing 26
chr4_+_147333056 5.97 ENSRNOT00000012137
peroxisome proliferator-activated receptor gamma
chr10_+_57260680 5.86 ENSRNOT00000035445
glycoprotein Ib platelet alpha subunit
chr20_-_5056474 5.74 ENSRNOT00000076375
ENSRNOT00000037191
ENSRNOT00000076863
immunoreceptor tyrosine-based inhibitory motif (ITIM) containing platelet receptor
chr8_+_42347811 5.64 ENSRNOT00000073897
olfactory receptor 8B3-like
chr16_-_49820235 5.46 ENSRNOT00000029628
sorbin and SH3 domain containing 2
chr3_+_125320680 5.46 ENSRNOT00000028891
hypothetical protein LOC681292
chr10_-_89374516 5.43 ENSRNOT00000028084
vesicle amine transport 1
chr4_+_154215250 5.43 ENSRNOT00000072465
murinoglobulin 2
chr14_+_107349414 5.40 ENSRNOT00000012255
similar to ribosomal protein L28
chr14_-_110883784 5.39 ENSRNOT00000086299
ENSRNOT00000068190
vaccinia related kinase 2
chr7_-_115981731 5.33 ENSRNOT00000036549
similar to secreted Ly6/uPAR related protein 2
chr16_+_2634603 5.25 ENSRNOT00000019113
HESX homeobox 1
chr6_+_58388333 5.25 ENSRNOT00000036337
similar to 40S ribosomal protein S2
chr16_-_68968248 5.16 ENSRNOT00000016885
eukaryotic translation initiation factor 4E binding protein 1
chr9_+_81535483 5.09 ENSRNOT00000077285
actin related protein 2/3 complex, subunit 2
chr10_+_34938667 5.05 ENSRNOT00000086443
ENSRNOT00000059104
5-phosphohydroxy-L-lysine phospho-lyase
chr19_+_55929609 5.02 ENSRNOT00000068231
ENSRNOT00000077701
copine 7
chr10_-_37055282 4.89 ENSRNOT00000086193
ENSRNOT00000065584
heterogeneous nuclear ribonucleoprotein A/B
chr1_-_37990007 4.48 ENSRNOT00000081054

chr8_-_66863476 4.38 ENSRNOT00000018820
ribosomal protein lateral stalk subunit P1
chr7_-_5195955 4.36 ENSRNOT00000040141
olfactory receptor 896
chr18_+_56379890 4.33 ENSRNOT00000078764
platelet derived growth factor receptor beta
chr6_+_27975849 4.21 ENSRNOT00000060810
dystrobrevin, beta
chr16_+_31734944 4.14 ENSRNOT00000059673
palladin, cytoskeletal associated protein
chr5_-_62001196 4.08 ENSRNOT00000012602
tRNA methyltransferase O
chr5_+_164808323 4.08 ENSRNOT00000011005
natriuretic peptide A
chr17_+_39156840 4.07 ENSRNOT00000022447
prolactin family 7, subfamily b, member 1
chr10_-_110182291 4.02 ENSRNOT00000015178
ENSRNOT00000054936
casein kinase 1, delta
chr3_-_73755510 3.85 ENSRNOT00000083628
olfactory receptor 502
chr13_-_45068077 3.85 ENSRNOT00000004969
minichromosome maintenance complex component 6
chr10_+_31813814 3.68 ENSRNOT00000009573
hepatitis A virus cellular receptor 1
chrX_-_16532089 3.66 ENSRNOT00000093156
diacylglycerol kinase kappa
chr15_-_45524582 3.65 ENSRNOT00000081912
guanylate cyclase 1 soluble subunit beta 2
chr3_-_73510015 3.63 ENSRNOT00000072248
olfactory receptor 483
chr1_-_72941869 3.59 ENSRNOT00000032306
EPS8-like 1
chr8_-_116856548 3.57 ENSRNOT00000043825
ring finger protein 123
chr10_+_37032043 3.56 ENSRNOT00000037303
ENSRNOT00000091242
5-phosphohydroxy-L-lysine phospho-lyase
chr4_+_140377565 3.54 ENSRNOT00000082723
inositol 1,4,5-trisphosphate receptor, type 1
chr10_-_87407634 3.48 ENSRNOT00000016657
keratin 23
chr9_+_41006800 3.43 ENSRNOT00000079413
ENSRNOT00000034214
protease, serine, 39
chr16_+_61926586 3.39 ENSRNOT00000058884

chr10_+_59613398 3.35 ENSRNOT00000025553
nuclear cap binding subunit 3
chr1_+_171797516 3.34 ENSRNOT00000088110
PPFIA binding protein 2
chr1_-_175895510 3.27 ENSRNOT00000064535
eukaryotic translation initiation factor 4, gamma 2
chr2_+_188748359 3.20 ENSRNOT00000028038
SHC adaptor protein 1
chr10_+_87808493 3.12 ENSRNOT00000065405
hypothetical protein LOC680428
chr6_+_102477036 3.10 ENSRNOT00000087132
RAD51 paralog B
chr14_+_11988671 3.04 ENSRNOT00000003207
RasGEF domain family, member 1B
chr3_+_11207542 3.02 ENSRNOT00000013546
proline-rich coiled-coil 2B
chr18_+_16544508 2.91 ENSRNOT00000020601
elongator acetyltransferase complex subunit 2
chr3_-_76279104 2.86 ENSRNOT00000007796
olfactory receptor 608
chr5_-_137014375 2.83 ENSRNOT00000066165
ENSRNOT00000091866
lysine demethylase 4A
chr3_+_76179214 2.79 ENSRNOT00000071281
similar to olfactory receptor 1161
chr8_-_63291966 2.78 ENSRNOT00000077762

chr10_-_88107232 2.72 ENSRNOT00000019330
ENSRNOT00000076770
keratin 9
chr3_-_12467662 2.68 ENSRNOT00000051893
zinc finger and BTB domain containing 34
chr10_-_16788126 2.67 ENSRNOT00000077386
ATPase H+ transporting V0 subunit e1

Network of associatons between targets according to the STRING database.

First level regulatory network of Tal1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.8 47.1 GO:1901423 response to benzene(GO:1901423)
8.1 56.8 GO:0015670 carbon dioxide transport(GO:0015670)
7.6 22.9 GO:0061744 motor behavior(GO:0061744)
7.2 29.0 GO:0044339 canonical Wnt signaling pathway involved in osteoblast differentiation(GO:0044339)
6.9 48.5 GO:0019374 galactolipid metabolic process(GO:0019374)
6.9 20.8 GO:0045799 positive regulation of chromatin assembly or disassembly(GO:0045799)
5.6 61.2 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
5.4 80.6 GO:0015671 oxygen transport(GO:0015671)
5.1 15.4 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
5.0 49.8 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
4.5 89.1 GO:0033008 positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
4.1 16.5 GO:1904373 response to kainic acid(GO:1904373)
3.9 11.8 GO:0071663 immunoglobulin production in mucosal tissue(GO:0002426) T-helper 1 cell activation(GO:0035711) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663) regulation of thymocyte migration(GO:2000410) regulation of B cell chemotaxis(GO:2000537) positive regulation of B cell chemotaxis(GO:2000538)
3.7 18.4 GO:0046149 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
3.3 84.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
3.2 9.7 GO:1990743 protein sialylation(GO:1990743)
3.2 9.7 GO:0003330 regulation of extracellular matrix constituent secretion(GO:0003330) positive regulation of extracellular matrix constituent secretion(GO:0003331)
3.2 31.8 GO:0042866 pyruvate biosynthetic process(GO:0042866)
3.1 56.1 GO:0038065 collagen-activated signaling pathway(GO:0038065)
2.8 14.2 GO:0015889 cobalamin transport(GO:0015889)
2.8 16.9 GO:0034197 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
2.8 58.6 GO:0046597 negative regulation of viral entry into host cell(GO:0046597)
2.7 16.2 GO:0001866 NK T cell proliferation(GO:0001866)
2.5 22.9 GO:0001955 blood vessel maturation(GO:0001955)
2.4 58.2 GO:0030574 collagen catabolic process(GO:0030574)
2.3 6.9 GO:0042560 folic acid-containing compound catabolic process(GO:0009397) pteridine-containing compound catabolic process(GO:0042560)
2.1 6.4 GO:1902167 positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:1902167)
2.0 6.0 GO:2000230 pancreatic stellate cell proliferation(GO:0072343) regulation of pancreatic stellate cell proliferation(GO:2000229) negative regulation of pancreatic stellate cell proliferation(GO:2000230)
2.0 33.4 GO:0018119 leukocyte migration involved in inflammatory response(GO:0002523) protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119)
1.8 29.1 GO:0002227 innate immune response in mucosa(GO:0002227)
1.8 30.7 GO:0032460 negative regulation of protein oligomerization(GO:0032460)
1.7 10.2 GO:0071918 urea transmembrane transport(GO:0071918)
1.6 6.4 GO:0016554 cytidine to uridine editing(GO:0016554)
1.6 21.7 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
1.5 17.9 GO:0051639 actin filament network formation(GO:0051639)
1.4 24.4 GO:0002693 positive regulation of cellular extravasation(GO:0002693)
1.4 6.8 GO:1904045 cellular response to aldosterone(GO:1904045)
1.4 4.1 GO:1902304 positive regulation of potassium ion export(GO:1902304)
1.3 5.4 GO:2000659 regulation of interleukin-1-mediated signaling pathway(GO:2000659)
1.3 9.3 GO:0016259 selenocysteine metabolic process(GO:0016259)
1.3 10.6 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
1.3 16.3 GO:0035634 response to stilbenoid(GO:0035634)
1.2 4.9 GO:1904580 regulation of intracellular mRNA localization(GO:1904580)
1.2 6.0 GO:1904717 positive regulation of receptor clustering(GO:1903911) regulation of AMPA glutamate receptor clustering(GO:1904717)
1.2 32.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.1 4.3 GO:0072276 cell migration involved in vasculogenesis(GO:0035441) VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091) metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277)
1.0 9.4 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
1.0 5.2 GO:1990928 response to amino acid starvation(GO:1990928)
1.0 11.8 GO:2000258 complement activation, lectin pathway(GO:0001867) negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258)
0.9 15.8 GO:0035855 megakaryocyte development(GO:0035855)
0.9 55.6 GO:0070527 platelet aggregation(GO:0070527)
0.9 5.4 GO:0010637 negative regulation of mitochondrial fusion(GO:0010637)
0.9 7.1 GO:0050861 positive regulation of B cell receptor signaling pathway(GO:0050861)
0.9 4.4 GO:1904401 cellular response to Thyroid stimulating hormone(GO:1904401)
0.9 10.5 GO:0046485 ether lipid metabolic process(GO:0046485)
0.9 60.3 GO:0032094 response to food(GO:0032094)
0.9 8.6 GO:0001554 luteolysis(GO:0001554)
0.8 16.2 GO:0031268 pseudopodium organization(GO:0031268)
0.8 11.4 GO:0045603 positive regulation of endothelial cell differentiation(GO:0045603)
0.8 5.3 GO:0030916 otic vesicle formation(GO:0030916)
0.7 2.2 GO:0042335 cuticle development(GO:0042335)
0.7 3.7 GO:0033005 positive regulation of mast cell activation(GO:0033005)
0.7 3.5 GO:0050882 voluntary musculoskeletal movement(GO:0050882)
0.7 15.3 GO:0033006 regulation of mast cell activation involved in immune response(GO:0033006) regulation of mast cell degranulation(GO:0043304)
0.7 11.7 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.7 48.8 GO:0048286 lung alveolus development(GO:0048286)
0.6 7.1 GO:0097264 self proteolysis(GO:0097264)
0.6 3.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.6 19.6 GO:0071353 cellular response to interleukin-4(GO:0071353)
0.6 7.7 GO:0045351 type I interferon biosynthetic process(GO:0045351)
0.6 1.2 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.6 22.9 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.5 64.3 GO:0031638 zymogen activation(GO:0031638)
0.5 47.0 GO:0031016 pancreas development(GO:0031016)
0.5 10.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.5 2.1 GO:0002921 negative regulation of humoral immune response(GO:0002921)
0.5 3.6 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.5 12.5 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095) G2 DNA damage checkpoint(GO:0031572)
0.5 1.4 GO:0072695 negative regulation of DNA recombination at telomere(GO:0048239) regulation of DNA recombination at telomere(GO:0072695)
0.5 70.1 GO:0090501 RNA phosphodiester bond hydrolysis(GO:0090501)
0.5 8.9 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.5 6.5 GO:1990845 adaptive thermogenesis(GO:1990845)
0.4 15.5 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.4 7.7 GO:0034377 plasma lipoprotein particle assembly(GO:0034377)
0.4 4.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.4 0.4 GO:1901671 positive regulation of superoxide dismutase activity(GO:1901671) positive regulation of removal of superoxide radicals(GO:1904833)
0.4 19.3 GO:0070098 chemokine-mediated signaling pathway(GO:0070098)
0.4 8.4 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.4 11.9 GO:0032611 interleukin-1 beta production(GO:0032611)
0.3 4.1 GO:0071803 positive regulation of podosome assembly(GO:0071803)
0.3 2.2 GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463)
0.3 34.7 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.3 18.1 GO:0006611 protein export from nucleus(GO:0006611)
0.3 2.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.2 14.6 GO:0030101 natural killer cell activation(GO:0030101)
0.2 0.5 GO:0061534 gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.2 2.4 GO:0070327 thyroid hormone transport(GO:0070327)
0.2 6.1 GO:0070266 necroptotic process(GO:0070266)
0.2 16.8 GO:0006637 acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)
0.2 6.2 GO:0015701 bicarbonate transport(GO:0015701)
0.2 3.1 GO:1902751 positive regulation of G2/M transition of mitotic cell cycle(GO:0010971) positive regulation of cell cycle G2/M phase transition(GO:1902751)
0.2 4.0 GO:0007020 microtubule nucleation(GO:0007020)
0.2 2.9 GO:0043248 proteasome assembly(GO:0043248)
0.2 1.0 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 5.3 GO:2000272 negative regulation of receptor activity(GO:2000272)
0.2 1.1 GO:2000254 regulation of male germ cell proliferation(GO:2000254)
0.1 0.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.1 7.5 GO:0045670 regulation of osteoclast differentiation(GO:0045670)
0.1 3.0 GO:0030488 tRNA methylation(GO:0030488)
0.1 0.6 GO:2000819 regulation of nucleotide-excision repair(GO:2000819)
0.1 6.5 GO:0030838 positive regulation of actin filament polymerization(GO:0030838)
0.1 5.0 GO:0071277 cellular response to calcium ion(GO:0071277)
0.1 1.1 GO:0001778 plasma membrane repair(GO:0001778)
0.1 3.7 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 2.7 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.1 1.1 GO:0036065 fucosylation(GO:0036065)
0.1 1.2 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 0.3 GO:0061526 acetylcholine secretion(GO:0061526)
0.1 3.3 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 1.1 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 3.2 GO:0035094 response to nicotine(GO:0035094)
0.0 0.9 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.3 GO:0002155 thyroid hormone mediated signaling pathway(GO:0002154) regulation of thyroid hormone mediated signaling pathway(GO:0002155)
0.0 0.1 GO:1904823 purine nucleobase transmembrane transport(GO:1904823)
0.0 1.2 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 3.4 GO:0051607 defense response to virus(GO:0051607)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 0.0 GO:0046487 glyoxylate metabolic process(GO:0046487) negative regulation of glial cell migration(GO:1903976)
0.0 1.5 GO:0007160 cell-matrix adhesion(GO:0007160)
0.0 1.4 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
21.0 84.0 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
7.9 79.5 GO:0008290 F-actin capping protein complex(GO:0008290)
4.8 38.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
2.6 48.5 GO:0042589 zymogen granule membrane(GO:0042589)
2.1 14.5 GO:0071438 invadopodium membrane(GO:0071438)
1.8 87.2 GO:0016235 aggresome(GO:0016235)
1.5 49.7 GO:0008305 integrin complex(GO:0008305)
1.2 16.2 GO:0031143 pseudopodium(GO:0031143)
0.9 9.8 GO:0005797 Golgi medial cisterna(GO:0005797)
0.9 3.5 GO:0031088 platelet dense granule membrane(GO:0031088)
0.8 5.1 GO:0036194 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.8 3.9 GO:0033588 Elongator holoenzyme complex(GO:0033588)
0.7 15.5 GO:1902711 GABA-A receptor complex(GO:1902711)
0.7 3.3 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.6 17.9 GO:0001891 phagocytic cup(GO:0001891)
0.6 3.1 GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex(GO:0033063)
0.6 4.9 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.6 44.6 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.4 11.7 GO:0000788 nuclear nucleosome(GO:0000788)
0.4 5.9 GO:0031362 intrinsic component of external side of plasma membrane(GO:0031233) anchored component of external side of plasma membrane(GO:0031362)
0.3 3.8 GO:0042555 MCM complex(GO:0042555)
0.3 9.4 GO:0030904 retromer complex(GO:0030904)
0.3 2.1 GO:0097209 epidermal lamellar body(GO:0097209)
0.3 4.3 GO:0043202 lysosomal lumen(GO:0043202)
0.3 9.3 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.3 507.8 GO:0005615 extracellular space(GO:0005615)
0.3 6.5 GO:0019013 viral nucleocapsid(GO:0019013)
0.3 20.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 18.1 GO:0005643 nuclear pore(GO:0005643)
0.3 24.4 GO:0005901 caveola(GO:0005901)
0.2 6.4 GO:0005771 multivesicular body(GO:0005771)
0.2 2.7 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.2 2.3 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 31.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.2 16.2 GO:0016605 PML body(GO:0016605)
0.2 1.1 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.7 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 4.0 GO:0005876 spindle microtubule(GO:0005876)
0.1 4.1 GO:0044295 axonal growth cone(GO:0044295)
0.1 36.8 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 2.8 GO:0005721 pericentric heterochromatin(GO:0005721)
0.1 8.8 GO:0001750 photoreceptor outer segment(GO:0001750)
0.1 1.2 GO:0000812 Swr1 complex(GO:0000812)
0.1 1.4 GO:0000783 telomere cap complex(GO:0000782) nuclear telomere cap complex(GO:0000783)
0.1 11.8 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 6.0 GO:0030426 growth cone(GO:0030426)
0.1 6.2 GO:0005882 intermediate filament(GO:0005882)
0.1 14.5 GO:0045121 membrane raft(GO:0045121) membrane microdomain(GO:0098857)
0.1 4.0 GO:0032587 ruffle membrane(GO:0032587)
0.1 21.9 GO:0005925 focal adhesion(GO:0005925)
0.1 7.8 GO:0000793 condensed chromosome(GO:0000793)
0.0 3.4 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 2.6 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.6 GO:0030057 desmosome(GO:0030057)
0.0 9.2 GO:0016607 nuclear speck(GO:0016607)
0.0 2.7 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.0 1.2 GO:0030027 lamellipodium(GO:0030027)
0.0 35.7 GO:0070062 extracellular exosome(GO:0070062)
0.0 1.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 9.6 GO:0005768 endosome(GO:0005768)
0.0 3.4 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
28.0 84.0 GO:0031720 haptoglobin binding(GO:0031720)
15.7 47.1 GO:0016748 succinyltransferase activity(GO:0016748)
14.8 89.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
8.3 49.7 GO:0070051 fibrinogen binding(GO:0070051)
8.0 160.6 GO:0004806 triglyceride lipase activity(GO:0004806)
8.0 31.8 GO:0004743 pyruvate kinase activity(GO:0004743)
7.1 56.8 GO:0022842 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
5.6 33.4 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
5.4 37.8 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
4.0 12.0 GO:0004852 uroporphyrinogen-III synthase activity(GO:0004852)
3.8 38.1 GO:0038064 collagen receptor activity(GO:0038064)
3.4 16.9 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
2.6 10.3 GO:0015265 urea channel activity(GO:0015265)
2.6 7.7 GO:0019961 interferon binding(GO:0019961)
2.4 9.7 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
2.3 22.9 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.3 6.9 GO:0016882 cyclo-ligase activity(GO:0016882)
2.3 18.1 GO:0005049 nuclear export signal receptor activity(GO:0005049)
2.1 16.8 GO:0003996 acyl-CoA ligase activity(GO:0003996)
2.0 54.2 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
1.8 14.2 GO:0031419 cobalamin binding(GO:0031419)
1.8 10.6 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
1.6 6.5 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
1.6 79.5 GO:0030507 spectrin binding(GO:0030507)
1.6 6.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
1.5 10.5 GO:0016803 ether hydrolase activity(GO:0016803)
1.4 4.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
1.1 15.5 GO:0005237 inhibitory extracellular ligand-gated ion channel activity(GO:0005237)
1.1 32.2 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.0 4.1 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426)
1.0 20.2 GO:0005537 mannose binding(GO:0005537)
1.0 9.1 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.9 3.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.9 99.2 GO:0004540 ribonuclease activity(GO:0004540)
0.9 6.0 GO:0050544 arachidonic acid binding(GO:0050544)
0.8 5.1 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.8 9.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
0.8 4.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.8 31.1 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.8 3.2 GO:0048408 epidermal growth factor binding(GO:0048408)
0.8 92.4 GO:0005178 integrin binding(GO:0005178)
0.8 21.7 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.7 3.6 GO:0008453 alanine-glyoxylate transaminase activity(GO:0008453)
0.7 18.4 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.7 14.5 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.7 20.2 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.6 16.2 GO:0031489 myosin V binding(GO:0031489)
0.6 11.8 GO:0001848 complement binding(GO:0001848)
0.6 8.4 GO:0042301 phosphate ion binding(GO:0042301)
0.6 122.8 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.4 5.2 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.4 2.9 GO:0061133 endopeptidase activator activity(GO:0061133)
0.4 11.9 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 19.9 GO:0070888 E-box binding(GO:0070888)
0.4 6.5 GO:0005522 profilin binding(GO:0005522)
0.4 2.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
0.4 1.9 GO:0016936 galactoside binding(GO:0016936)
0.4 5.3 GO:0030550 acetylcholine receptor inhibitor activity(GO:0030550)
0.4 4.0 GO:0050321 tau-protein kinase activity(GO:0050321)
0.3 1.0 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.3 8.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.3 6.2 GO:0015106 bicarbonate transmembrane transporter activity(GO:0015106)
0.3 2.4 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.3 7.1 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.3 15.3 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 19.4 GO:0048029 monosaccharide binding(GO:0048029)
0.3 29.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.3 5.0 GO:0008483 transaminase activity(GO:0008483)
0.2 3.1 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.2 3.7 GO:0001618 virus receptor activity(GO:0001618)
0.2 11.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 3.9 GO:0010181 FMN binding(GO:0010181)
0.2 7.5 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.2 1.1 GO:0046920 alpha-(1->3)-fucosyltransferase activity(GO:0046920)
0.2 7.7 GO:0001077 transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077)
0.2 3.1 GO:0000400 four-way junction DNA binding(GO:0000400)
0.2 15.5 GO:0004896 cytokine receptor activity(GO:0004896)
0.2 12.9 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.2 0.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.2 17.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.1 1.2 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
0.1 3.7 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 4.1 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.1 3.8 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.1 2.7 GO:0046961 proton-transporting ATPase activity, rotational mechanism(GO:0046961)
0.1 1.2 GO:1990405 protein antigen binding(GO:1990405)
0.1 1.4 GO:0043047 single-stranded telomeric DNA binding(GO:0043047)
0.1 6.0 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 0.3 GO:0031531 thyrotropin-releasing hormone receptor binding(GO:0031531)
0.1 2.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.4 GO:0030295 protein kinase activator activity(GO:0030295)
0.1 38.7 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 11.7 GO:0042393 histone binding(GO:0042393)
0.1 23.9 GO:0008047 enzyme activator activity(GO:0008047)
0.1 6.0 GO:1990837 sequence-specific double-stranded DNA binding(GO:1990837)
0.1 32.8 GO:0008289 lipid binding(GO:0008289)
0.0 5.2 GO:0051015 actin filament binding(GO:0051015)
0.0 1.2 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.0 2.7 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 4.1 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 6.0 GO:0030246 carbohydrate binding(GO:0030246)
0.0 7.0 GO:0045296 cadherin binding(GO:0045296)
0.0 1.2 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.3 GO:0043236 laminin binding(GO:0043236)
0.0 10.0 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.6 GO:0003697 single-stranded DNA binding(GO:0003697)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
4.3 43.0 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
3.2 138.8 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
1.6 41.9 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
1.4 33.4 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.8 184.2 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.8 7.7 ST TYPE I INTERFERON PATHWAY Type I Interferon (alpha/beta IFN) Pathway
0.7 14.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.7 25.0 PID EPO PATHWAY EPO signaling pathway
0.6 31.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.6 2.9 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
0.5 12.5 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.4 11.4 PID ALK1 PATHWAY ALK1 signaling events
0.4 4.3 PID NECTIN PATHWAY Nectin adhesion pathway
0.4 6.5 PID ECADHERIN KERATINOCYTE PATHWAY E-cadherin signaling in keratinocytes
0.4 10.6 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.4 22.9 ST FAS SIGNALING PATHWAY Fas Signaling Pathway
0.3 10.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.3 4.0 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.3 6.0 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 3.5 ST GAQ PATHWAY G alpha q Pathway
0.2 6.8 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.2 4.5 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.2 6.0 PID FGF PATHWAY FGF signaling pathway
0.1 5.2 PID INSULIN PATHWAY Insulin Pathway
0.1 9.3 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 5.1 PID CDC42 PATHWAY CDC42 signaling events
0.1 1.1 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 2.6 PID AURORA B PATHWAY Aurora B signaling
0.1 1.1 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 1.1 PID CMYB PATHWAY C-MYB transcription factor network

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 115.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
6.5 58.2 REACTOME DEFENSINS Genes involved in Defensins
4.2 89.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
3.5 172.7 REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT Genes involved in Lipid digestion, mobilization, and transport
2.8 49.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
1.9 49.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
1.8 66.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
1.4 20.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
1.3 31.8 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
1.1 51.5 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.9 17.7 REACTOME INTRINSIC PATHWAY Genes involved in Intrinsic Pathway
0.6 9.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.6 15.5 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.5 8.4 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.5 7.7 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.4 9.4 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.4 10.9 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.4 27.9 REACTOME ANTIGEN PROCESSING CROSS PRESENTATION Genes involved in Antigen processing-Cross presentation
0.4 3.2 REACTOME INTEGRIN ALPHAIIB BETA3 SIGNALING Genes involved in Integrin alphaIIb beta3 signaling
0.3 3.8 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.3 9.1 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.2 11.8 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 4.1 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 10.4 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 2.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 3.1 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 1.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 5.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 3.2 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.1 0.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.1 0.6 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.1 4.3 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 4.4 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 2.7 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.4 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
0.0 0.6 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.4 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.1 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins