ISMARA results: Tal1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Tal1

Z-value: 1.49

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Transcription factors associated with Tal1

Gene Symbol	Gene ID	Gene Info
Tal1 NCBI RGD Ensembl	ENSRNOG00000025051	TAL bHLH transcription factor 1, erythroid differentiation factor

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Tal1	rn6_v1_chr5_+_133864798_133864798	0.53	4.8e-25	Click!

Activity profile of Tal1 motif

Sorted Z-values of Tal1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_+_151172206 Show fit	89.06	ENSRNOT00000013778	Fgr NCBI RGD Ensembl Show fit	FGR proto-oncogene, Src family tyrosine kinase
chr4_+_70614524 Show fit	64.35	ENSRNOT00000041100	Prss3 NCBI RGD Ensembl Show fit	protease, serine 3
chr20_-_5806097 Show fit	62.92	ENSRNOT00000000611	Clps NCBI RGD Ensembl Show fit	colipase
chr1_+_279798187 Show fit	61.23	ENSRNOT00000024065	Pnlip NCBI RGD Ensembl Show fit	pancreatic lipase
chr4_+_70689737 Show fit	58.17	ENSRNOT00000018852	Prss2 NCBI RGD Ensembl Show fit	protease, serine, 2
chr9_-_23493081 Show fit	56.81	ENSRNOT00000072144	Rhag NCBI RGD Ensembl Show fit	Rh-associated glycoprotein
chr1_+_279867034 Show fit	53.34	ENSRNOT00000024164	Pnliprp1 NCBI RGD Ensembl Show fit	pancreatic lipase-related protein 1
chr20_-_2191640 Show fit	52.58	ENSRNOT00000001016	Trim10 NCBI RGD Ensembl Show fit	tripartite motif-containing 10
chr10_-_90415070 Show fit	49.75	ENSRNOT00000055179	Itga2b NCBI RGD Ensembl Show fit	integrin subunit alpha 2b
chr10_-_15590220 Show fit	49.65	ENSRNOT00000048977	Hba-a2 NCBI RGD Ensembl Show fit	hemoglobin alpha, adult chain 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Tal1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.5	89.1	GO:0033008	positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of mast cell degranulation(GO:0043306)
3.3	84.6	GO:0051016	barbed-end actin filament capping(GO:0051016)
5.4	80.6	GO:0015671	oxygen transport(GO:0015671)
0.5	70.1	GO:0090501	RNA phosphodiester bond hydrolysis(GO:0090501)
0.5	64.3	GO:0031638	zymogen activation(GO:0031638)
5.6	61.2	GO:0061365	positive regulation of triglyceride lipase activity(GO:0061365)
0.9	60.3	GO:0032094	response to food(GO:0032094)
2.8	58.6	GO:0046597	negative regulation of viral entry into host cell(GO:0046597)
2.4	58.2	GO:0030574	collagen catabolic process(GO:0030574)
8.1	56.8	GO:0015670	carbon dioxide transport(GO:0015670)

Showing 1 to 10 of 130 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	507.8	GO:0005615	extracellular space(GO:0005615)
1.8	87.2	GO:0016235	aggresome(GO:0016235)
21.0	84.0	GO:0031838	haptoglobin-hemoglobin complex(GO:0031838)
7.9	79.5	GO:0008290	F-actin capping protein complex(GO:0008290)
1.5	49.7	GO:0008305	integrin complex(GO:0008305)
2.6	48.5	GO:0042589	zymogen granule membrane(GO:0042589)
0.6	44.6	GO:0005758	mitochondrial intermembrane space(GO:0005758)
4.8	38.1	GO:0097197	tetraspanin-enriched microdomain(GO:0097197)
0.1	36.8	GO:0005759	mitochondrial matrix(GO:0005759)
0.0	35.7	GO:0070062	extracellular exosome(GO:0070062)

Showing 1 to 10 of 61 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
8.0	160.6	GO:0004806	triglyceride lipase activity(GO:0004806)
0.6	122.8	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.9	99.2	GO:0004540	ribonuclease activity(GO:0004540)
0.8	92.4	GO:0005178	integrin binding(GO:0005178)
14.8	89.1	GO:0034988	Fc-gamma receptor I complex binding(GO:0034988)
28.0	84.0	GO:0031720	haptoglobin binding(GO:0031720)
1.6	79.5	GO:0030507	spectrin binding(GO:0030507)
7.1	56.8	GO:0022842	leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
2.0	54.2	GO:0004181	metallocarboxypeptidase activity(GO:0004181)
8.3	49.7	GO:0070051	fibrinogen binding(GO:0070051)

Showing 1 to 10 of 106 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.8	184.2	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
3.2	138.8	PID EPHRINB REV PATHWAY	Ephrin B reverse signaling
4.3	43.0	PID TCR JNK PATHWAY	JNK signaling in the CD4+ TCR pathway
1.6	41.9	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.4	33.4	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.6	31.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	25.0	PID EPO PATHWAY	EPO signaling pathway
0.4	22.9	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway
0.7	14.5	PID EPHA2 FWD PATHWAY	EPHA2 forward signaling
0.5	12.5	PID P38 MKK3 6PATHWAY	p38 MAPK signaling pathway

Showing 1 to 10 of 30 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.5	172.7	REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT	Genes involved in Lipid digestion, mobilization, and transport
6.8	115.3	REACTOME METABOLISM OF PORPHYRINS	Genes involved in Metabolism of porphyrins
4.2	89.1	REACTOME PLATELET SENSITIZATION BY LDL	Genes involved in Platelet sensitization by LDL
1.8	66.9	REACTOME AMINE COMPOUND SLC TRANSPORTERS	Genes involved in Amine compound SLC transporters
6.5	58.2	REACTOME DEFENSINS	Genes involved in Defensins
1.1	51.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
1.9	49.9	REACTOME GENERATION OF SECOND MESSENGER MOLECULES	Genes involved in Generation of second messenger molecules
2.8	49.7	REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS	Genes involved in p130Cas linkage to MAPK signaling for integrins
1.3	31.8	REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS	Genes involved in Regulation of gene expression in beta cells
0.4	27.9	REACTOME ANTIGEN PROCESSING CROSS PRESENTATION	Genes involved in Antigen processing-Cross presentation

Showing 1 to 10 of 38 entries

Results for Tal1

Z-value: 1.49

Motif logo

Transcription factors associated with Tal1

Activity-expression correlation:

Activity profile of Tal1 motif

Sorted Z-values of Tal1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Tal1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: