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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for T

Z-value: 1.20

Motif logo

Transcription factors associated with T

Gene Symbol Gene ID Gene Info
ENSRNOG00000012229 T brachyury transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Trn6_v1_chr1_-_52894832_52894832-0.347.7e-10Click!

Activity profile of T motif

Sorted Z-values of T motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_23289266 88.90 ENSRNOT00000061708
betaine-homocysteine S-methyltransferase 2
chr1_+_238222521 74.90 ENSRNOT00000024000
aldehyde dehydrogenase 1 family, member A1
chr20_-_45126062 60.65 ENSRNOT00000000720
similar to KIAA1919 protein
chr11_+_74057361 48.78 ENSRNOT00000048746
carboxypeptidase N subunit 2
chr1_-_240601744 48.44 ENSRNOT00000024093
aldehyde dehydrogenase family 1, subfamily A7
chr2_+_68821004 47.81 ENSRNOT00000083713
epidermal growth factor
chr1_+_222310920 47.43 ENSRNOT00000091465
MACRO domain containing 1
chrX_+_110818716 42.12 ENSRNOT00000086308
ring finger protein 128, E3 ubiquitin protein ligase
chr1_+_148240504 42.09 ENSRNOT00000085373
Cytochrome P450, family 2, subfamily c, polypeptide 7-like
chr6_-_127508452 38.92 ENSRNOT00000073709
protein Z-dependent protease inhibitor-like
chr1_-_102780381 37.42 ENSRNOT00000080132
serum amyloid A4
chr15_+_10120206 35.33 ENSRNOT00000033048
retinoic acid receptor, beta
chr4_-_148845267 31.34 ENSRNOT00000037397
transmembrane protein 72
chr2_-_210749991 27.92 ENSRNOT00000051261
ENSRNOT00000052403
glutathione S-transferase, mu 6-like
chr12_+_40466495 27.82 ENSRNOT00000001816
aldehyde dehydrogenase 2 family (mitochondrial)
chr16_-_81834945 27.24 ENSRNOT00000037806
coagulation factor VII
chr14_+_22251499 26.60 ENSRNOT00000087991
ENSRNOT00000002705
UDP glucuronosyltransferase 2 family, polypeptide A1
chr2_-_188596222 25.29 ENSRNOT00000027920
ephrin A1
chr8_-_58195884 25.15 ENSRNOT00000010573
acetyl-CoA acetyltransferase 1
chr4_+_122365093 24.73 ENSRNOT00000024011
Kruppel-like factor 15
chr3_-_176706896 23.96 ENSRNOT00000017337
protein tyrosine kinase 6
chr3_+_142383278 22.51 ENSRNOT00000017742
forkhead box A2
chrX_-_111102464 22.11 ENSRNOT00000084176
ripply transcriptional repressor 1
chr9_-_63637677 20.34 ENSRNOT00000049259
SATB homeobox 2
chr3_+_61620192 19.49 ENSRNOT00000065426
homeo box D9
chr7_+_144577465 18.78 ENSRNOT00000021647
homeo box C10
chr2_+_127845034 16.85 ENSRNOT00000044804
La ribonucleoprotein domain family, member 1B
chr3_-_172566010 16.35 ENSRNOT00000071913
ATP synthase, H+ transporting, mitochondrial F1 complex, epsilon subunit
chr8_+_72405748 16.31 ENSRNOT00000023952
carbonic anhydrase 12
chr13_-_51297621 16.17 ENSRNOT00000030926
NADH:ubiquinone oxidoreductase subunit V3
chr13_+_49092306 15.96 ENSRNOT00000000039
NUAK family kinase 2
chr10_-_61772250 15.89 ENSRNOT00000092338
ENSRNOT00000085394
ENSRNOT00000046110
serine racemase
chr13_-_25262469 15.73 ENSRNOT00000019921
ring finger protein 152
chr16_+_20962227 15.39 ENSRNOT00000027615
solute carrier family 25, member 42
chr11_+_88699222 14.80 ENSRNOT00000084177
FYVE, RhoGEF and PH domain containing 4
chrX_-_111179152 14.78 ENSRNOT00000089115
MORC family CW-type zinc finger 4
chr1_+_256382791 14.77 ENSRNOT00000022549
cytochrome P450, family 26, subfamily a, polypeptide 1
chr10_-_82116621 13.05 ENSRNOT00000003977
ENSRNOT00000051497
ENSRNOT00000085451
ATP binding cassette subfamily C member 3
chrX_-_75566481 12.98 ENSRNOT00000003714
zinc finger, DHHC-type containing 15
chr2_-_210766501 12.02 ENSRNOT00000025800
glutathione S-transferase mu 3
chr12_-_30314519 11.80 ENSRNOT00000001220
zinc finger, BED-type containing 5
chr5_-_56536772 11.29 ENSRNOT00000060765
DEXD/H-box helicase 58
chr14_-_87701884 10.49 ENSRNOT00000079338
motile sperm domain containing 1
chr13_-_50509916 10.39 ENSRNOT00000076747
renin
chr18_-_3662654 9.90 ENSRNOT00000092854
ENSRNOT00000016167
NPC intracellular cholesterol transporter 1
chr1_-_213635546 9.68 ENSRNOT00000018861
sirtuin 3
chr16_+_46731403 9.27 ENSRNOT00000017624
teneurin transmembrane protein 3
chrX_+_54266687 8.74 ENSRNOT00000058309
LRRGT00076-like
chr18_+_16616937 8.68 ENSRNOT00000093641
molybdenum cofactor sulfurase
chr1_+_172264473 8.64 ENSRNOT00000050651
olfactory receptor 246
chr1_-_89559960 8.63 ENSRNOT00000092133
sodium voltage-gated channel beta subunit 1
chr11_+_27208564 8.34 ENSRNOT00000002158
MAP3K7 C-terminal like
chr2_+_127459012 8.16 ENSRNOT00000093685
ENSRNOT00000072675
inturned planar cell polarity protein
chr1_+_197839430 8.13 ENSRNOT00000025043
rabaptin, RAB GTPase binding effector protein 2
chr14_-_82975263 7.98 ENSRNOT00000024165
solute carrier family 5 member 1
chr15_+_34552410 7.63 ENSRNOT00000027802
KH and NYN domain containing
chr10_-_47630799 7.48 ENSRNOT00000057907
solute carrier family 47 member 2
chr16_-_49574314 7.34 ENSRNOT00000017568
ENSRNOT00000085535
ENSRNOT00000017054
PDZ and LIM domain 3
chr15_+_107486555 7.15 ENSRNOT00000074277

chr3_+_151126591 7.01 ENSRNOT00000025859
myosin heavy chain 7B
chr20_+_47494424 6.90 ENSRNOT00000087718
SEC63 homolog, protein translocation regulator
chr1_-_91832058 6.80 ENSRNOT00000079088
nudix hydrolase 19
chr3_-_164728338 6.45 ENSRNOT00000035463
family with sequence similarity 65, member C
chr7_-_143187594 6.22 ENSRNOT00000011732
ENSRNOT00000083466
keratin 84
chr2_-_153140894 6.03 ENSRNOT00000075166

chr6_-_103605256 5.94 ENSRNOT00000006005
DDB1 and CUL4 associated factor 5
chr3_-_77792014 5.61 ENSRNOT00000091085
olfactory receptor 671
chr1_-_22404002 5.56 ENSRNOT00000044098
trace amine-associated receptor 8a
chr1_+_220243473 5.42 ENSRNOT00000084650
ENSRNOT00000027091
mitochondrial ribosomal protein L11
chr2_-_220663305 5.29 ENSRNOT00000090294

chr1_+_213636093 5.17 ENSRNOT00000019642
proteasome 26S subunit, non-ATPase 13
chr19_+_52374298 5.16 ENSRNOT00000092131
ATPase secretory pathway Ca2+ transporting 2
chr12_+_46869836 5.05 ENSRNOT00000084421
sirtuin 4
chr13_+_56513286 5.00 ENSRNOT00000015596
zinc finger and BTB domain containing 41
chr8_-_36842370 4.90 ENSRNOT00000074011
prostate and testis expressed 3
chr19_+_39126589 4.84 ENSRNOT00000027561
syntrophin, beta 2
chr8_-_22336794 4.79 ENSRNOT00000066340
adaptor-related protein complex 1, mu 2 subunit
chr3_-_118427851 4.78 ENSRNOT00000055995
family with sequence similarity 227, member B
chr3_-_149563476 4.77 ENSRNOT00000071869

chr1_+_172813394 4.68 ENSRNOT00000090059
olfactory receptor 272
chr10_-_13175863 4.61 ENSRNOT00000034380
protease, serine, 33
chr3_-_61636038 4.61 ENSRNOT00000086887

chr20_+_47494270 4.54 ENSRNOT00000036365
SEC63 homolog, protein translocation regulator
chr12_-_35318685 4.43 ENSRNOT00000074199

chr7_+_6096690 4.42 ENSRNOT00000051694
olfactory receptor 1006
chr7_+_78732904 4.42 ENSRNOT00000088433
dendritic cell-specific transmembrane protein
chr6_-_21112734 4.39 ENSRNOT00000079819
RAS guanyl releasing protein 3
chr19_-_37907714 4.38 ENSRNOT00000026361
chymotrypsin-like
chr2_+_160291450 4.32 ENSRNOT00000075563

chr20_+_6356423 4.23 ENSRNOT00000000628
cyclin-dependent kinase inhibitor 1A
chr10_-_51778939 4.19 ENSRNOT00000078675
ENSRNOT00000057562
myocardin
chr7_+_38945836 4.12 ENSRNOT00000006455
coiled-coil glutamate-rich protein 1
chr1_+_218487824 4.05 ENSRNOT00000017958
MAS related GPR family member D
chr3_+_100768637 3.92 ENSRNOT00000083542
brain-derived neurotrophic factor
chr1_-_73121085 3.78 ENSRNOT00000073464
similar to NACHT, leucine rich repeat and PYD containing 2
chr10_-_61045355 3.73 ENSRNOT00000048167
olfactory receptor 1514
chr3_+_11607225 3.68 ENSRNOT00000072685
ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 4
chr5_+_148320438 3.56 ENSRNOT00000018742
penta-EF hand domain containing 1
chr3_+_160695911 3.54 ENSRNOT00000018510
seminal vesicle secretory protein 6
chr1_-_22596475 3.43 ENSRNOT00000021510
trace-amine-associated receptor 1
chr1_-_87937516 3.38 ENSRNOT00000087522
eukaryotic translation initiation factor 3, subunit K
chr8_-_22173797 3.35 ENSRNOT00000042314
ENSRNOT00000079949
cell division cycle 37
chr20_-_5931417 3.29 ENSRNOT00000092383
solute carrier family 26 member 8
chr2_-_1511591 3.29 ENSRNOT00000087906
ENSRNOT00000014709
calpastatin
chr3_+_113423693 3.28 ENSRNOT00000021091
Huntingtin interacting protein K
chr2_+_211880262 3.22 ENSRNOT00000038315
solute carrier family 25, member 54
chr16_-_82999608 3.20 ENSRNOT00000078867
testis expressed 29
chr2_-_149754776 3.11 ENSRNOT00000035057
similar to hypothetical protein C130079G13
chr4_+_1584083 3.05 ENSRNOT00000087099
olfactory receptor 1244
chr1_+_79181855 3.05 ENSRNOT00000037132
pregnancy-specific beta 1-glycoprotein
chr4_+_174181644 2.97 ENSRNOT00000011555
capping actin protein of muscle Z-line alpha subunit 3
chr8_-_124399494 2.88 ENSRNOT00000037883
transforming growth factor, beta receptor 2
chr5_+_162323373 2.82 ENSRNOT00000033150
arylacetamide deacetylase-like 3
chr11_-_64968437 2.69 ENSRNOT00000059541
COX17 cytochrome c oxidase copper chaperone
chr4_+_117679342 2.69 ENSRNOT00000021272
folliculogenesis specific bHLH transcription factor
chr11_+_81769178 2.64 ENSRNOT00000038826
TBCC domain containing 1
chr1_-_154165524 2.60 ENSRNOT00000023468
Hikeshi, heat shock protein nuclear import factor
chr18_+_38847632 2.59 ENSRNOT00000014916
ELMO domain-containing protein 2-like
chr10_-_61088827 2.57 ENSRNOT00000047421
olfactory receptor 1517
chr19_+_9622611 2.53 ENSRNOT00000061498
solute carrier family 38, member 7
chr16_-_82999827 2.51 ENSRNOT00000041223
testis expressed 29
chr1_+_168844875 2.44 ENSRNOT00000051398

chr9_-_99365192 2.37 ENSRNOT00000047012
similar to ribosomal protein L36
chr17_+_3924473 2.36 ENSRNOT00000061470
similar to cathepsin R
chr4_+_45120576 2.33 ENSRNOT00000077961
suppression of tumorigenicity 7
chr18_-_60835739 2.33 ENSRNOT00000039569
similar to glyceraldehyde-3-phosphate dehydrogenase
chr7_+_129595192 2.31 ENSRNOT00000071151
zinc finger, DHHC-type containing 25
chr1_-_215858034 2.26 ENSRNOT00000027656
insulin 2
chr7_+_77066955 2.15 ENSRNOT00000008700
outer dense fiber of sperm tails 1
chr2_+_205617220 2.15 ENSRNOT00000025365
DENN domain containing 2C
chr10_+_38788992 2.08 ENSRNOT00000009727
growth differentiation factor 9
chr4_-_180505916 2.01 ENSRNOT00000086465

chr1_+_172599610 2.00 ENSRNOT00000049903
olfactory receptor 260
chr19_+_24496569 1.97 ENSRNOT00000004982
MGAT4 family, member D
chr10_+_61033113 1.97 ENSRNOT00000043016
olfactory receptor 1513
chr1_-_173129038 1.90 ENSRNOT00000075693
olfactory receptor 10A3-like
chr10_+_46783979 1.89 ENSRNOT00000005237
GID complex subunit 4
chr8_-_41445722 1.88 ENSRNOT00000011381
spleen protein 1 precursor
chr7_-_130120579 1.83 ENSRNOT00000044376
mitogen-activated protein kinase 12
chr10_-_50574539 1.76 ENSRNOT00000034261
COX10 heme A:farnesyltransferase cytochrome c oxidase assembly factor
chr8_+_40410604 1.43 ENSRNOT00000049392
olfactory receptor 1202
chr7_-_75569778 1.42 ENSRNOT00000040687
Ac1254
chr10_-_41546346 1.36 ENSRNOT00000058627
uncharacterized LOC102552882
chr7_+_78649875 1.35 ENSRNOT00000006243
dendrocyte expressed seven transmembrane protein
chr20_-_8574082 1.30 ENSRNOT00000048845
MAM domain containing glycosylphosphatidylinositol anchor 1
chr4_-_32087600 1.18 ENSRNOT00000013841
SEM1, 26S proteasome complex subunit
chr7_-_142180997 1.06 ENSRNOT00000087632
transcription factor CP2
chr10_-_109966782 1.02 ENSRNOT00000078052
ENSRNOT00000075041
RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase
chr6_+_110749705 0.97 ENSRNOT00000084348
leucine rich repeat containing 74A
chr1_+_31436712 0.92 ENSRNOT00000038102

chr1_-_141533908 0.87 ENSRNOT00000020117
mesoderm posterior bHLH transcription factor 1
chr8_+_41936959 0.77 ENSRNOT00000042601
olfactory receptor 1222
chr1_+_172051215 0.71 ENSRNOT00000048370
olfactory receptor 235
chr6_-_11860001 0.67 ENSRNOT00000052280
H2A histone family, member Z
chr10_+_11206226 0.54 ENSRNOT00000006979
transcription factor AP-4
chr10_+_28449335 0.54 ENSRNOT00000029118
ATPase phospholipid transporting 10B (putative)
chr13_-_91737053 0.51 ENSRNOT00000083561
Fc fragment of IgE receptor Ia
chr3_+_74411668 0.51 ENSRNOT00000045439
olfactory receptor 526
chr7_-_143453544 0.50 ENSRNOT00000034450
ENSRNOT00000083956
keratin 1
keratin 5
chr11_-_55240241 0.35 ENSRNOT00000064614
developmental pluripotency associated 4
chr1_-_226049929 0.33 ENSRNOT00000007320
bestrophin 1
chr10_+_61160125 0.28 ENSRNOT00000074715
olfactory receptor 1519
chr1_+_150225373 0.24 ENSRNOT00000051266
olfactory receptor 30
chr7_+_70697050 0.21 ENSRNOT00000045964
R3H domain containing 2
chr1_-_226353611 0.20 ENSRNOT00000037624
diacylglycerol lipase, alpha
chr12_+_10255416 0.16 ENSRNOT00000092720
G protein-coupled receptor 12
chr14_-_46153212 0.15 ENSRNOT00000079269
NACHT and WD repeat domain containing 2
chr8_+_41987849 0.14 ENSRNOT00000073800
olfactory receptor 143-like
chr6_+_129438158 0.03 ENSRNOT00000005953
bradykinin receptor B1
chr9_-_81565416 0.01 ENSRNOT00000083582
angio-associated, migratory cell protein

Network of associatons between targets according to the STRING database.

First level regulatory network of T

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
11.9 47.4 GO:0051725 protein de-ADP-ribosylation(GO:0051725)
11.1 88.9 GO:0043102 amino acid salvage(GO:0043102) L-methionine salvage(GO:0071267)
9.7 48.4 GO:0035106 operant conditioning(GO:0035106)
9.4 74.9 GO:0042905 optic cup morphogenesis involved in camera-type eye development(GO:0002072) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
9.1 27.2 GO:1904612 response to 2,3,7,8-tetrachlorodibenzodioxine(GO:1904612) response to thyrotropin-releasing hormone(GO:1905225)
8.4 25.2 GO:0072237 acetyl-CoA catabolic process(GO:0046356) ketone body catabolic process(GO:0046952) metanephric proximal tubule development(GO:0072237)
7.5 22.5 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432)
6.3 25.3 GO:0014028 notochord formation(GO:0014028)
6.0 47.8 GO:0007262 STAT protein import into nucleus(GO:0007262)
5.9 35.3 GO:0003406 retinal pigment epithelium development(GO:0003406)
5.3 15.9 GO:0046416 D-amino acid metabolic process(GO:0046416)
4.0 12.0 GO:0018916 nitrobenzene metabolic process(GO:0018916)
3.8 11.4 GO:0031204 posttranslational protein targeting to membrane, translocation(GO:0031204)
3.7 14.8 GO:0034653 diterpenoid catabolic process(GO:0016103) retinoic acid catabolic process(GO:0034653)
2.9 2.9 GO:0003430 growth plate cartilage chondrocyte growth(GO:0003430)
2.8 11.3 GO:0009597 detection of virus(GO:0009597)
2.8 27.8 GO:0006068 ethanol catabolic process(GO:0006068)
2.6 15.4 GO:0015860 purine nucleoside transmembrane transport(GO:0015860)
2.2 13.0 GO:0042908 xenobiotic transport(GO:0042908)
2.1 14.8 GO:0030035 microspike assembly(GO:0030035)
2.1 10.4 GO:0002018 angiotensin maturation(GO:0002003) renin-angiotensin regulation of aldosterone production(GO:0002018)
2.0 26.6 GO:0052695 cellular glucuronidation(GO:0052695)
1.8 20.3 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
1.7 8.6 GO:0021966 corticospinal neuron axon guidance(GO:0021966)
1.6 16.3 GO:0055064 chloride ion homeostasis(GO:0055064)
1.6 19.5 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
1.6 8.0 GO:0001951 intestinal D-glucose absorption(GO:0001951)
1.6 18.8 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
1.6 42.1 GO:0019373 epoxygenase P450 pathway(GO:0019373)
1.5 14.7 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
1.5 42.1 GO:0042036 negative regulation of cytokine biosynthetic process(GO:0042036)
1.4 4.2 GO:1900222 regulation of cell growth by extracellular stimulus(GO:0001560) positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation(GO:0003257) negative regulation of beta-amyloid clearance(GO:1900222) positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation(GO:2000721)
1.3 16.4 GO:0032525 somite rostral/caudal axis specification(GO:0032525)
1.2 3.6 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
1.1 9.9 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
1.0 15.7 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
1.0 28.2 GO:0060575 intestinal epithelial cell differentiation(GO:0060575)
1.0 24.7 GO:0003299 muscle hypertrophy in response to stress(GO:0003299) cardiac muscle hypertrophy in response to stress(GO:0014898)
1.0 13.0 GO:0016188 synaptic vesicle maturation(GO:0016188)
0.8 2.5 GO:0015817 histidine transport(GO:0015817) L-histidine transmembrane transport(GO:0089709) L-histidine transport(GO:1902024)
0.8 9.3 GO:0097264 self proteolysis(GO:0097264)
0.8 8.7 GO:0006777 Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720)
0.8 2.3 GO:0033861 negative regulation of NAD(P)H oxidase activity(GO:0033861)
0.7 2.7 GO:1904959 regulation of cytochrome-c oxidase activity(GO:1904959)
0.7 2.6 GO:0051684 maintenance of Golgi location(GO:0051684)
0.6 8.2 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.6 16.3 GO:0015986 energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986)
0.5 33.0 GO:0006953 acute-phase response(GO:0006953)
0.5 2.1 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.5 3.9 GO:0061193 taste bud development(GO:0061193)
0.5 3.2 GO:0015866 ADP transport(GO:0015866)
0.5 1.4 GO:0034241 positive regulation of macrophage fusion(GO:0034241)
0.4 6.3 GO:0043248 proteasome assembly(GO:0043248)
0.4 3.3 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.3 7.5 GO:0006855 drug transmembrane transport(GO:0006855)
0.3 1.3 GO:0051964 negative regulation of synapse assembly(GO:0051964)
0.3 16.0 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.3 16.2 GO:0042775 mitochondrial ATP synthesis coupled electron transport(GO:0042775)
0.3 3.3 GO:0060334 regulation of interferon-gamma-mediated signaling pathway(GO:0060334)
0.3 0.9 GO:0060913 mesodermal cell migration(GO:0008078) cardiac cell fate determination(GO:0060913) cardiac vascular smooth muscle cell differentiation(GO:0060947) cell migration involved in heart formation(GO:0060974) regulation of heart induction by regulation of canonical Wnt signaling pathway(GO:0090081)
0.2 6.2 GO:0045616 regulation of keratinocyte differentiation(GO:0045616)
0.2 5.4 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.2 3.3 GO:1902358 oxalate transport(GO:0019532) sulfate transmembrane transport(GO:1902358)
0.2 3.4 GO:0001731 formation of translation preinitiation complex(GO:0001731)
0.2 3.8 GO:0050716 positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718)
0.2 0.5 GO:0045399 positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) positive regulation of granulocyte macrophage colony-stimulating factor biosynthetic process(GO:0045425)
0.2 3.7 GO:0097503 sialylation(GO:0097503)
0.1 0.5 GO:2001269 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001269)
0.1 8.3 GO:0000186 activation of MAPKK activity(GO:0000186)
0.1 3.0 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 1.8 GO:0008535 respiratory chain complex IV assembly(GO:0008535)
0.1 0.2 GO:0099542 trans-synaptic signaling by lipid(GO:0099541) trans-synaptic signaling by endocannabinoid(GO:0099542)
0.1 5.2 GO:0090280 positive regulation of calcium ion import(GO:0090280)
0.1 22.7 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.1 3.7 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.0 0.3 GO:0030321 transepithelial chloride transport(GO:0030321)
0.0 2.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.5 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 1.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 0.4 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.0 0.5 GO:0045332 phospholipid translocation(GO:0045332)
0.0 1.8 GO:0045445 myoblast differentiation(GO:0045445)
0.0 3.3 GO:0050821 protein stabilization(GO:0050821)
0.0 23.7 GO:0050911 detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.0 2.8 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.7 GO:0071392 cellular response to estradiol stimulus(GO:0071392)
0.0 4.4 GO:0007265 Ras protein signal transduction(GO:0007265)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 18.8 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
2.0 16.3 GO:0045261 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
1.4 4.2 GO:0070557 PCNA-p21 complex(GO:0070557)
1.3 37.4 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.8 7.0 GO:0097512 cardiac myofibril(GO:0097512)
0.7 2.9 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.7 6.3 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.6 26.6 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.4 8.6 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.4 3.4 GO:0033290 eukaryotic 43S preinitiation complex(GO:0016282) eukaryotic 48S preinitiation complex(GO:0033290)
0.3 16.2 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.3 3.0 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 33.5 GO:0072562 blood microparticle(GO:0072562)
0.3 4.4 GO:0032045 guanyl-nucleotide exchange factor complex(GO:0032045)
0.3 20.3 GO:0000118 histone deacetylase complex(GO:0000118)
0.3 3.6 GO:0030127 COPII vesicle coat(GO:0030127)
0.2 3.9 GO:0030061 mitochondrial crista(GO:0030061)
0.2 73.1 GO:0005759 mitochondrial matrix(GO:0005759)
0.2 5.9 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.2 3.2 GO:0033391 chromatoid body(GO:0033391)
0.2 2.6 GO:0031616 spindle pole centrosome(GO:0031616)
0.2 36.7 GO:0005770 late endosome(GO:0005770)
0.2 24.0 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 4.8 GO:0030131 clathrin adaptor complex(GO:0030131)
0.1 14.8 GO:0030175 filopodium(GO:0030175)
0.1 2.2 GO:0001520 outer dense fiber(GO:0001520)
0.1 8.0 GO:0031526 brush border membrane(GO:0031526)
0.1 0.7 GO:0001740 Barr body(GO:0001740)
0.1 6.2 GO:0045095 keratin filament(GO:0045095)
0.1 15.2 GO:0005765 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.1 5.2 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 7.3 GO:0030018 Z disc(GO:0030018)
0.1 15.9 GO:0045177 apical part of cell(GO:0045177)
0.1 25.0 GO:0043235 receptor complex(GO:0043235)
0.1 56.2 GO:0005615 extracellular space(GO:0005615)
0.1 8.2 GO:0036064 ciliary basal body(GO:0036064)
0.1 2.7 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 7.6 GO:0005769 early endosome(GO:0005769)
0.1 13.1 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.1 1.8 GO:0070069 cytochrome complex(GO:0070069)
0.1 142.9 GO:0070062 extracellular exosome(GO:0070062)
0.1 5.3 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 43.7 GO:0005739 mitochondrion(GO:0005739)
0.0 3.8 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 1.4 GO:0010008 endosome membrane(GO:0010008)
0.0 14.8 GO:0030054 cell junction(GO:0030054)
0.0 0.2 GO:0043196 varicosity(GO:0043196)
0.0 88.7 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
41.1 123.3 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
11.1 88.9 GO:0008172 S-methyltransferase activity(GO:0008172)
8.4 25.2 GO:0016453 C-acetyltransferase activity(GO:0016453)
5.6 27.8 GO:0070404 NADH binding(GO:0070404)
5.3 15.9 GO:0003941 L-serine ammonia-lyase activity(GO:0003941)
4.9 14.8 GO:0008401 retinoic acid 4-hydroxylase activity(GO:0008401)
3.1 15.4 GO:0051185 adenosine-diphosphatase activity(GO:0043262) coenzyme transporter activity(GO:0051185)
2.9 35.3 GO:0003708 retinoic acid receptor activity(GO:0003708)
2.8 47.8 GO:0042813 Wnt-activated receptor activity(GO:0042813)
2.2 8.7 GO:0008265 Mo-molybdopterin cofactor sulfurase activity(GO:0008265)
1.7 8.6 GO:0086062 voltage-gated sodium channel activity involved in Purkinje myocyte action potential(GO:0086062)
1.7 5.1 GO:0047708 biotinidase activity(GO:0047708)
1.4 13.0 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
1.4 4.2 GO:0019912 cyclin-dependent protein kinase activating kinase activity(GO:0019912)
1.4 42.1 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
1.3 6.7 GO:0030280 structural constituent of epidermis(GO:0030280)
1.3 16.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
1.2 57.1 GO:0019213 deacetylase activity(GO:0019213)
1.0 39.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.9 26.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.8 2.5 GO:0005290 L-histidine transmembrane transporter activity(GO:0005290)
0.8 16.3 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.8 8.0 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.7 12.6 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.6 25.3 GO:0046875 ephrin receptor binding(GO:0046875)
0.6 7.5 GO:0015238 drug transmembrane transporter activity(GO:0015238)
0.6 2.9 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.6 3.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
0.5 9.0 GO:0001594 trace-amine receptor activity(GO:0001594)
0.5 22.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.5 3.2 GO:0005347 ATP transmembrane transporter activity(GO:0005347) ADP transmembrane transporter activity(GO:0015217)
0.4 24.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.3 10.8 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.3 8.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.3 2.7 GO:0016531 copper chaperone activity(GO:0016531)
0.3 29.3 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 5.2 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.2 1.8 GO:0004311 farnesyltranstransferase activity(GO:0004311)
0.2 3.3 GO:0019531 oxalate transmembrane transporter activity(GO:0019531)
0.2 3.3 GO:0043422 protein kinase B binding(GO:0043422)
0.2 27.2 GO:0001948 glycoprotein binding(GO:0001948)
0.2 8.6 GO:0015485 cholesterol binding(GO:0015485)
0.2 7.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.2 3.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.2 4.2 GO:0070412 R-SMAD binding(GO:0070412)
0.2 14.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.2 3.7 GO:0008373 sialyltransferase activity(GO:0008373)
0.2 36.9 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 11.3 GO:0003725 double-stranded RNA binding(GO:0003725)
0.1 14.0 GO:0008565 protein transporter activity(GO:0008565)
0.1 6.5 GO:0005088 Ras guanyl-nucleotide exchange factor activity(GO:0005088)
0.1 18.4 GO:0001227 transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227)
0.1 0.5 GO:0019767 IgE receptor activity(GO:0019767)
0.1 5.4 GO:0019843 rRNA binding(GO:0019843)
0.1 1.8 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.4 GO:0043022 ribosome binding(GO:0043022)
0.1 3.3 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.0 7.0 GO:0003774 motor activity(GO:0003774)
0.0 5.9 GO:0052689 carboxylic ester hydrolase activity(GO:0052689)
0.0 12.5 GO:0001228 transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228)
0.0 12.5 GO:0005549 odorant binding(GO:0005549)
0.0 4.5 GO:0008083 growth factor activity(GO:0008083)
0.0 0.5 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 1.0 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.0 14.9 GO:0004984 olfactory receptor activity(GO:0004984)
0.0 2.0 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 2.3 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 4.0 GO:0044212 transcription regulatory region DNA binding(GO:0044212)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 47.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.9 35.3 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.8 25.3 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.8 38.7 PID HNF3A PATHWAY FOXA1 transcription factor network
0.6 4.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.4 24.6 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.4 9.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 69.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 4.4 PID RAS PATHWAY Regulation of Ras family activation
0.1 6.1 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 2.9 PID ALK1 PATHWAY ALK1 signaling events
0.1 3.3 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 3.9 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 4.2 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 0.5 PID FCER1 PATHWAY Fc-epsilon receptor I signaling in mast cells

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
12.8 102.7 REACTOME ETHANOL OXIDATION Genes involved in Ethanol oxidation
2.7 27.2 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
2.4 47.8 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
1.4 26.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
1.4 25.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
1.1 13.0 REACTOME RECYCLING OF BILE ACIDS AND SALTS Genes involved in Recycling of bile acids and salts
1.0 11.3 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
1.0 16.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
0.8 22.5 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.6 4.8 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.5 7.5 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.5 14.8 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.4 4.2 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.3 3.3 REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR Genes involved in Signaling by constitutively active EGFR
0.2 16.2 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.2 8.6 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.2 3.7 REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS Genes involved in Termination of O-glycan biosynthesis
0.2 14.8 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.2 2.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 1.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.1 8.7 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 5.7 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 9.6 REACTOME DOWNSTREAM SIGNALING EVENTS OF B CELL RECEPTOR BCR Genes involved in Downstream Signaling Events Of B Cell Receptor (BCR)
0.1 8.0 REACTOME TRANSPORT OF GLUCOSE AND OTHER SUGARS BILE SALTS AND ORGANIC ACIDS METAL IONS AND AMINE COMPOUNDS Genes involved in Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds
0.1 1.0 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.4 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.7 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.0 3.4 REACTOME G ALPHA S SIGNALLING EVENTS Genes involved in G alpha (s) signalling events