ISMARA results: Stat5a

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat5a

Z-value: 1.36

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Transcription factors associated with Stat5a

Gene Symbol	Gene ID	Gene Info
Stat5a NCBI RGD Ensembl	ENSRNOG00000019496	signal transducer and activator of transcription 5A

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat5a	rn6_v1_chr10_+_88764732_88764732	-0.20	4.1e-04	Click!

Activity profile of Stat5a motif

Sorted Z-values of Stat5a motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr4_+_70776046 Show fit	44.33	ENSRNOT00000040403	Prss1 NCBI RGD Ensembl Show fit	protease, serine 1
chr16_+_6970342 Show fit	44.27	ENSRNOT00000061294 ENSRNOT00000048344	Itih4 NCBI RGD Ensembl Show fit	inter-alpha-trypsin inhibitor heavy chain family, member 4
chr2_+_54466280 Show fit	43.66	ENSRNOT00000033112	C6 NCBI RGD Ensembl Show fit	complement C6
chr16_+_54164431 Show fit	41.88	ENSRNOT00000090763	Fgl1 NCBI RGD Ensembl Show fit	fibrinogen-like 1
chr2_+_181987217 Show fit	31.44	ENSRNOT00000034521	Fgg NCBI RGD Ensembl Show fit	fibrinogen gamma chain
chr2_+_104744461 Show fit	31.04	ENSRNOT00000016083 ENSRNOT00000082627	Cp NCBI RGD Ensembl Show fit	ceruloplasmin
chr3_-_63836017 Show fit	30.86	ENSRNOT00000030978	AABR07052585.1 NCBI RGD Ensembl Show fit
chr13_-_47397890 Show fit	30.21	ENSRNOT00000005505	C4bpb NCBI RGD Ensembl Show fit	complement component 4 binding protein, beta
chr5_-_77492013 Show fit	30.08	ENSRNOT00000012293	LOC259245 NCBI RGD Ensembl Show fit	alpha-2u globulin PGCL5
chr8_-_52937972 Show fit	30.00	ENSRNOT00000007789	Nnmt NCBI RGD Ensembl Show fit	nicotinamide N-methyltransferase

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat5a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	307.9	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
0.6	143.9	GO:0010951	negative regulation of endopeptidase activity(GO:0010951)
2.9	69.1	GO:0030574	collagen catabolic process(GO:0030574)
3.1	67.5	GO:0019373	epoxygenase P450 pathway(GO:0019373)
1.3	47.8	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
1.6	45.5	GO:0030212	hyaluronan metabolic process(GO:0030212)
4.9	44.4	GO:0052697	xenobiotic glucuronidation(GO:0052697)
14.6	43.7	GO:0001969	activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969)
2.0	41.3	GO:0035634	response to stilbenoid(GO:0035634)
0.6	38.4	GO:0035383	acyl-CoA metabolic process(GO:0006637) thioester metabolic process(GO:0035383)

Showing 1 to 10 of 590 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	455.8	GO:0005615	extracellular space(GO:0005615)
2.1	231.3	GO:0072562	blood microparticle(GO:0072562)
0.3	87.5	GO:0005759	mitochondrial matrix(GO:0005759)
0.1	71.5	GO:0042175	nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
9.3	65.4	GO:0005579	membrane attack complex(GO:0005579)
7.9	63.2	GO:0005577	fibrinogen complex(GO:0005577)
0.1	61.7	GO:0005739	mitochondrion(GO:0005739)
3.7	58.8	GO:0042612	MHC class I protein complex(GO:0042612)
1.9	56.8	GO:0042588	zymogen granule(GO:0042588)
0.7	44.7	GO:0005788	endoplasmic reticulum lumen(GO:0005788)

Showing 1 to 10 of 206 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	285.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
1.8	209.1	GO:0004867	serine-type endopeptidase inhibitor activity(GO:0004867)
0.2	207.5	GO:0004984	olfactory receptor activity(GO:0004984)
0.4	111.6	GO:0030246	carbohydrate binding(GO:0030246)
0.2	100.4	GO:0005549	odorant binding(GO:0005549)
3.0	86.8	GO:0008392	arachidonic acid epoxygenase activity(GO:0008392)
2.3	70.7	GO:0015020	glucuronosyltransferase activity(GO:0015020)
11.8	59.0	GO:0005550	pheromone binding(GO:0005550)
1.3	45.5	GO:0004364	glutathione transferase activity(GO:0004364)
2.8	44.7	GO:0015125	bile acid transmembrane transporter activity(GO:0015125)

Showing 1 to 10 of 390 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.2	280.9	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
2.5	77.3	PID INTEGRIN2 PATHWAY	Beta2 integrin cell surface interactions
1.2	64.0	PID HNF3A PATHWAY	FOXA1 transcription factor network
0.2	48.5	NABA ECM GLYCOPROTEINS	Genes encoding structural ECM glycoproteins
0.2	37.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.9	32.4	PID AMB2 NEUTROPHILS PATHWAY	amb2 Integrin signaling
2.7	29.9	ST JAK STAT PATHWAY	Jak-STAT Pathway
0.6	23.9	PID IL2 STAT5 PATHWAY	IL2 signaling events mediated by STAT5
0.5	21.8	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.7	21.0	PID WNT SIGNALING PATHWAY	Wnt signaling network

Showing 1 to 10 of 81 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
4.0	111.2	REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX	Genes involved in Degradation of the extracellular matrix
1.7	107.9	REACTOME PHASE II CONJUGATION	Genes involved in Phase II conjugation
4.7	75.4	REACTOME COMMON PATHWAY	Genes involved in Common Pathway
0.4	73.8	REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES	Genes involved in Metabolism of amino acids and derivatives
3.4	71.3	REACTOME COMPLEMENT CASCADE	Genes involved in Complement cascade
1.3	62.5	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
2.9	55.0	REACTOME GLUCURONIDATION	Genes involved in Glucuronidation
1.4	53.9	REACTOME STRIATED MUSCLE CONTRACTION	Genes involved in Striated Muscle Contraction
3.9	50.9	REACTOME REGULATION OF COMPLEMENT CASCADE	Genes involved in Regulation of Complement cascade
1.7	49.6	REACTOME METAL ION SLC TRANSPORTERS	Genes involved in Metal ion SLC transporters

Showing 1 to 10 of 119 entries

Results for Stat5a

Z-value: 1.36

Motif logo

Transcription factors associated with Stat5a

Activity-expression correlation:

Activity profile of Stat5a motif

Sorted Z-values of Stat5a motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat5a

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: