ISMARA results: Stat2

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat2

Z-value: 2.04

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Transcription factors associated with Stat2

Gene Symbol	Gene ID	Gene Info
Stat2 NCBI RGD Ensembl	ENSRNOG00000031081	signal transducer and activator of transcription 2

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat2	rn6_v1_chr7_+_2691369_2691369	0.74	2.0e-56	Click!

Activity profile of Stat2 motif

Sorted Z-values of Stat2 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr5_-_58198782 Show fit	110.28	ENSRNOT00000023951	Ccl21 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 21
chr15_+_18710492 Show fit	101.52	ENSRNOT00000012532	Dnase1l3 NCBI RGD Ensembl Show fit	deoxyribonuclease 1-like 3
chr20_+_3990820 Show fit	86.58	ENSRNOT00000000528	Psmb8 NCBI RGD Ensembl Show fit	proteasome subunit beta 8
chr10_-_70744315 Show fit	75.67	ENSRNOT00000014865	Ccl5 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 5
chr4_+_153805993 Show fit	72.28	ENSRNOT00000056174	Usp18 NCBI RGD Ensembl Show fit	ubiquitin specific peptidase 18
chr3_-_171286413 Show fit	71.44	ENSRNOT00000008365 ENSRNOT00000081036	Zbp1 NCBI RGD Ensembl Show fit	Z-DNA binding protein 1
chr10_-_70342411 Show fit	70.88	ENSRNOT00000076269 ENSRNOT00000076477	Slfn13 NCBI RGD Ensembl Show fit	schlafen family member 13
chr13_+_89385859 Show fit	69.12	ENSRNOT00000047434	Fcgr3a NCBI RGD Ensembl Show fit	Fc fragment of IgG receptor IIIa
chr5_-_58183017 Show fit	68.40	ENSRNOT00000020982	Ccl19 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 19
chr20_-_27682861 Show fit	66.48	ENSRNOT00000057317	Fam26f NCBI RGD Ensembl Show fit	family with sequence similarity 26, member F

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	195.5	GO:0051607	defense response to virus(GO:0051607)
44.7	178.7	GO:0097026	dendritic cell dendrite assembly(GO:0097026)
6.3	176.2	GO:0035458	cellular response to interferon-beta(GO:0035458)
12.2	133.7	GO:0060340	positive regulation of type I interferon-mediated signaling pathway(GO:0060340)
11.0	132.2	GO:0038095	Fc-epsilon receptor signaling pathway(GO:0038095)
13.0	117.1	GO:0003374	dynamin polymerization involved in membrane fission(GO:0003373) dynamin polymerization involved in mitochondrial fission(GO:0003374)
1.6	116.6	GO:0019882	antigen processing and presentation(GO:0019882)
3.0	107.4	GO:0002474	antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
6.3	101.5	GO:0006309	apoptotic DNA fragmentation(GO:0006309)
18.9	75.7	GO:0050904	CD8-positive, alpha-beta T cell extravasation(GO:0035697) diapedesis(GO:0050904) cellular response to vitamin K(GO:0071307)

Showing 1 to 10 of 121 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	521.7	GO:0005829	cytosol(GO:0005829)
0.3	337.1	GO:0005615	extracellular space(GO:0005615)
1.0	323.7	GO:0009897	external side of plasma membrane(GO:0009897)
0.3	206.0	GO:0048471	perinuclear region of cytoplasm(GO:0048471)
21.6	129.7	GO:1990111	spermatoproteasome complex(GO:1990111)
0.2	107.7	GO:0005789	endoplasmic reticulum membrane(GO:0005789)
0.0	107.3	GO:0016021	integral component of membrane(GO:0016021)
3.8	105.4	GO:0042629	mast cell granule(GO:0042629)
0.2	90.9	GO:0005783	endoplasmic reticulum(GO:0005783)
11.7	82.1	GO:0042825	TAP complex(GO:0042825)

Showing 1 to 10 of 50 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.3	384.8	GO:0003924	GTPase activity(GO:0003924)
6.5	148.4	GO:0003950	NAD+ ADP-ribosyltransferase activity(GO:0003950)
4.5	135.3	GO:0008009	chemokine activity(GO:0008009)
26.4	132.2	GO:0019770	IgG receptor activity(GO:0019770)
4.5	120.6	GO:0070003	threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
11.3	102.1	GO:0001730	2'-5'-oligoadenylate synthetase activity(GO:0001730)
1.3	99.0	GO:0003725	double-stranded RNA binding(GO:0003725)
2.8	97.7	GO:0042605	peptide antigen binding(GO:0042605)
0.3	97.0	GO:0030246	carbohydrate binding(GO:0030246)
1.7	96.3	GO:0004520	endodeoxyribonuclease activity(GO:0004520)

Showing 1 to 10 of 89 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.6	190.7	NABA SECRETED FACTORS	Genes encoding secreted soluble factors
8.2	148.2	SA MMP CYTOKINE CONNECTION	Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.6	95.8	NABA ECM AFFILIATED	Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
2.9	91.6	ST GA12 PATHWAY	G alpha 12 Pathway
5.5	76.5	ST TYPE I INTERFERON PATHWAY	Type I Interferon (alpha/beta IFN) Pathway
2.0	75.7	PID SYNDECAN 4 PATHWAY	Syndecan-4-mediated signaling events
0.8	63.9	PID SMAD2 3NUCLEAR PATHWAY	Regulation of nuclear SMAD2/3 signaling
0.3	62.0	NABA MATRISOME ASSOCIATED	Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
2.2	55.1	PID P38 MK2 PATHWAY	p38 signaling mediated by MAPKAP kinases
2.0	48.3	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling

Showing 1 to 10 of 37 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
11.1	665.9	REACTOME INTERFERON ALPHA BETA SIGNALING	Genes involved in Interferon alpha/beta signaling
6.1	304.7	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
4.7	225.2	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
4.5	126.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
7.1	77.8	REACTOME TRAF3 DEPENDENT IRF ACTIVATION PATHWAY	Genes involved in TRAF3-dependent IRF activation pathway
5.5	71.4	REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI	Genes involved in RIP-mediated NFkB activation via DAI
3.9	65.5	REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC	Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC
1.7	64.4	REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS	Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
1.4	64.0	REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G	Genes involved in Vif-mediated degradation of APOBEC3G
0.3	56.5	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation

Showing 1 to 10 of 40 entries

Results for Stat2

Z-value: 2.04

Motif logo

Transcription factors associated with Stat2

Activity-expression correlation:

Activity profile of Stat2 motif

Sorted Z-values of Stat2 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat2

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: