ISMARA results: Stat1

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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Stat1

Z-value: 0.84

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Transcription factors associated with Stat1

Gene Symbol	Gene ID	Gene Info
Stat1 NCBI RGD Ensembl	ENSRNOG00000014079	signal transducer and activator of transcription 1

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
Stat1	rn6_v1_chr9_-_54327958_54327958	0.61	2.3e-34	Click!

Activity profile of Stat1 motif

Sorted Z-values of Stat1 motif

Top targets:

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr8_-_23148396 Show fit	40.95	ENSRNOT00000075237	Acp5 NCBI RGD Ensembl Show fit	acid phosphatase 5, tartrate resistant
chr1_-_98493978 Show fit	40.89	ENSRNOT00000023942	Nkg7 NCBI RGD Ensembl Show fit	natural killer cell granule protein 7
chr15_-_34392066 Show fit	36.74	ENSRNOT00000027315	Tgm1 NCBI RGD Ensembl Show fit	transglutaminase 1
chr3_-_72171078 Show fit	36.48	ENSRNOT00000009817	Serping1 NCBI RGD Ensembl Show fit	serpin family G member 1
chr19_+_54314865 Show fit	27.91	ENSRNOT00000024069	Irf8 NCBI RGD Ensembl Show fit	interferon regulatory factor 8
chr1_-_189181901 Show fit	26.33	ENSRNOT00000092022	Gp2 NCBI RGD Ensembl Show fit	glycoprotein 2
chr10_+_69412017 Show fit	25.40	ENSRNOT00000009448	Ccl2 NCBI RGD Ensembl Show fit	C-C motif chemokine ligand 2
chr1_-_176079125 Show fit	25.25	ENSRNOT00000047044	RGD1566189 NCBI RGD Ensembl Show fit	similar to ferritin light chain
chr10_-_56506446 Show fit	24.44	ENSRNOT00000021357	Acap1 NCBI RGD Ensembl Show fit	ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
chr8_+_127735258 Show fit	22.58	ENSRNOT00000015888	Vill NCBI RGD Ensembl Show fit	villin-like

Showing 1 to 10 of 156 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	47.8	GO:0050911	detection of chemical stimulus involved in sensory perception of smell(GO:0050911)
6.8	40.9	GO:0032929	negative regulation of superoxide anion generation(GO:0032929)
2.6	39.6	GO:0010838	positive regulation of keratinocyte proliferation(GO:0010838)
2.7	37.4	GO:0001867	complement activation, lectin pathway(GO:0001867)
1.3	27.9	GO:0044130	negative regulation of growth of symbiont in host(GO:0044130) negative regulation of growth of symbiont involved in interaction with host(GO:0044146)
6.6	26.3	GO:0002386	immune response in mucosal-associated lymphoid tissue(GO:0002386)
8.5	25.4	GO:2000502	negative regulation of natural killer cell chemotaxis(GO:2000502)
1.4	21.7	GO:0048245	eosinophil chemotaxis(GO:0048245)
7.2	21.6	GO:0060545	positive regulation of necroptotic process(GO:0060545)
1.3	21.4	GO:0010818	T cell chemotaxis(GO:0010818)

Showing 1 to 10 of 86 entries

Gene overrepresentation in cellular component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	95.7	GO:0005615	extracellular space(GO:0005615)
0.5	64.3	GO:0005913	cell-cell adherens junction(GO:0005913)
0.0	62.5	GO:0016021	integral component of membrane(GO:0016021)
0.4	51.3	GO:0072562	blood microparticle(GO:0072562)
0.3	26.3	GO:0031225	anchored component of membrane(GO:0031225)
6.4	25.4	GO:0044299	C-fiber(GO:0044299)
2.7	21.6	GO:0044194	cytolytic granule(GO:0044194)
0.3	21.0	GO:0000118	histone deacetylase complex(GO:0000118)
0.3	19.8	GO:0005788	endoplasmic reticulum lumen(GO:0005788)
2.7	18.8	GO:0060205	cytoplasmic membrane-bounded vesicle lumen(GO:0060205)

Showing 1 to 10 of 53 entries

Gene overrepresentation in molecular function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	56.4	GO:0004252	serine-type endopeptidase activity(GO:0004252)
0.0	47.8	GO:0004984	olfactory receptor activity(GO:0004984)
2.2	40.9	GO:0003993	acid phosphatase activity(GO:0003993)
6.5	39.0	GO:0031727	CCR2 chemokine receptor binding(GO:0031727)
2.1	37.4	GO:0001848	complement binding(GO:0001848)
3.7	36.7	GO:0003810	protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2	27.9	GO:0001078	transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3	25.9	GO:0003823	antigen binding(GO:0003823)
4.3	21.4	GO:0048248	CXCR3 chemokine receptor binding(GO:0048248)
1.6	21.0	GO:0031078	histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)

Showing 1 to 10 of 83 entries

Gene overrepresentation in curated gene sets: canonical pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	71.5	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
1.4	66.0	PID GMCSF PATHWAY	GMCSF-mediated signaling events
0.7	29.1	PID HDAC CLASSII PATHWAY	Signaling events mediated by HDAC Class II
0.5	27.8	PID IL4 2PATHWAY	IL4-mediated signaling events
0.6	24.4	PID ARF6 PATHWAY	Arf6 signaling events
0.4	23.3	PID DELTA NP63 PATHWAY	Validated transcriptional targets of deltaNp63 isoforms
0.9	21.6	SA CASPASE CASCADE	Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.6	21.4	PID CXCR3 PATHWAY	CXCR3-mediated signaling events
0.5	20.3	PID KIT PATHWAY	Signaling events mediated by Stem cell factor receptor (c-Kit)
0.7	18.8	PID IFNG PATHWAY	IFN-gamma pathway

Showing 1 to 10 of 27 entries

Gene overrepresentation in curated gene sets: REACTOME pathways category:

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Log-likelihood per target	Total log-likelihood	Term	Description
1.4	70.6	REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES	Genes involved in Chemokine receptors bind chemokines
1.0	61.8	REACTOME INTERFERON GAMMA SIGNALING	Genes involved in Interferon gamma signaling
0.7	40.9	REACTOME METABOLISM OF VITAMINS AND COFACTORS	Genes involved in Metabolism of vitamins and cofactors
1.5	32.2	REACTOME INTRINSIC PATHWAY	Genes involved in Intrinsic Pathway
0.7	30.4	REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL	Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.5	21.6	REACTOME INTRINSIC PATHWAY FOR APOPTOSIS	Genes involved in Intrinsic Pathway for Apoptosis
0.4	21.0	REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION	Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
1.2	18.8	REACTOME PURINE SALVAGE	Genes involved in Purine salvage
0.6	16.9	REACTOME GLUTATHIONE CONJUGATION	Genes involved in Glutathione conjugation
0.9	16.1	REACTOME GAP JUNCTION ASSEMBLY	Genes involved in Gap junction assembly

Showing 1 to 10 of 34 entries

Results for Stat1

Z-value: 0.84

Motif logo

Transcription factors associated with Stat1

Activity-expression correlation:

Activity profile of Stat1 motif

Sorted Z-values of Stat1 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of Stat1

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Gene overrepresentation in cellular component category:

Gene overrepresentation in molecular function category:

Gene overrepresentation in curated gene sets: canonical pathways category:

Gene overrepresentation in curated gene sets: REACTOME pathways category: