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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Spdef

Z-value: 0.58

Motif logo

Transcription factors associated with Spdef

Gene Symbol Gene ID Gene Info
ENSRNOG00000000491 SAM pointed domain containing ets transcription factor

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Spdefrn6_v1_chr20_-_7307280_7307284-0.412.6e-14Click!

Activity profile of Spdef motif

Sorted Z-values of Spdef motif

Promoter Log-likelihood Transcript Gene Gene Info
chr13_+_89774764 20.23 ENSRNOT00000005619
Rho GTPase activating protein 30
chr13_-_55173692 18.48 ENSRNOT00000064785
ENSRNOT00000029878
ENSRNOT00000029865
ENSRNOT00000060292
ENSRNOT00000000814
protein tyrosine phosphatase, receptor type, C
chr7_+_143629455 15.09 ENSRNOT00000073951
keratin 18
chrX_+_128897181 13.96 ENSRNOT00000008444
SH2 domain containing 1A
chr10_+_11810926 13.24 ENSRNOT00000036205
ENSRNOT00000036189
NLR family, CARD domain containing 3
chr10_+_47930633 12.60 ENSRNOT00000003515
GRB2-related adaptor protein
chrX_+_134979646 12.52 ENSRNOT00000006035
SAM and SH3 domain containing 3
chrX_+_15155230 12.33 ENSRNOT00000073289
ENSRNOT00000051439
Wiskott-Aldrich syndrome
chr8_+_55603968 12.19 ENSRNOT00000066848
POU class 2 associating factor 1
chr11_+_84745904 12.02 ENSRNOT00000002617
kelch-like family member 6
chr4_+_69138525 11.70 ENSRNOT00000073589
T cell receptor beta, variable 1
chr18_+_44716226 11.13 ENSRNOT00000086431
TNF alpha induced protein 8
chr14_-_64476796 10.86 ENSRNOT00000029104
glucosidase, beta, acid 3
chr1_+_260289589 10.74 ENSRNOT00000051058
DNA nucleotidylexotransferase
chr20_+_5040337 10.51 ENSRNOT00000068435
chloride intracellular channel 1
chr4_-_163227242 9.83 ENSRNOT00000091552
ENSRNOT00000077793
C-type lectin domain family 7, member A
chr20_+_9948908 9.41 ENSRNOT00000001541
ubiquitin associated and SH3 domain containing, A
chr3_+_161018511 9.08 ENSRNOT00000019804
ENSRNOT00000039664
WAP four-disulfide core domain 2
chr1_-_260254600 8.74 ENSRNOT00000019014
B-cell linker
chr5_+_154522119 8.71 ENSRNOT00000072618
E2F transcription factor 2
chr2_-_157759819 8.42 ENSRNOT00000015763
ENSRNOT00000016016
cyclin-L1-like
chr14_+_45062662 8.31 ENSRNOT00000059124
toll-like receptor 10
chr10_-_104628676 8.21 ENSRNOT00000010466
unc-13 homolog D
chr7_+_11077411 8.14 ENSRNOT00000007117
sphingosine-1-phosphate receptor 4
chr1_+_201620642 7.82 ENSRNOT00000093674
deleted in malignant brain tumors 1
chr15_-_33766438 7.71 ENSRNOT00000033977
adaptor-related protein complex 1, gamma 2 subunit
chrX_+_115351114 7.44 ENSRNOT00000047553
high-mobility group (nonhistone chromosomal) protein 1-like 1
chr5_-_169630340 7.44 ENSRNOT00000087043
potassium voltage-gated channel subfamily A regulatory beta subunit 2
chr1_-_85317968 7.41 ENSRNOT00000026891
glia maturation factor, gamma
chr13_+_52645257 7.38 ENSRNOT00000012801
ladinin 1
chr9_-_92616165 7.26 ENSRNOT00000056995
SP110 nuclear body protein
chr9_+_94745217 7.18 ENSRNOT00000051338
inositol polyphosphate-5-phosphatase D
chr2_+_183674522 7.03 ENSRNOT00000014433
transmembrane protein 154
chr8_+_116054465 6.80 ENSRNOT00000040056
cytokine inducible SH2-containing protein
chr8_+_102304095 6.77 ENSRNOT00000011358
solute carrier family 9 member A9
chr10_-_10767389 6.73 ENSRNOT00000066754
small integral membrane protein 22
chr6_+_12253788 6.66 ENSRNOT00000061675
protein phosphatase 1, regulatory subunit 21
chr9_+_65620658 6.63 ENSRNOT00000084498
caspase 8
chr7_-_132984110 6.51 ENSRNOT00000046626
high mobility group box 1, pseudogene 3
chr3_+_148150698 6.38 ENSRNOT00000087075
ENSRNOT00000010251
histocompatibility minor 13
chr5_-_154319629 5.95 ENSRNOT00000014415
lysophospholipase II
chr4_+_92431710 5.92 ENSRNOT00000049438
high mobility group protein B1-like
chr8_+_71914867 5.90 ENSRNOT00000023372
death-associated protein kinase 2
chr10_+_84986328 5.90 ENSRNOT00000085830
ENSRNOT00000067665
oxysterol binding protein-like 7
chr1_+_199217016 5.87 ENSRNOT00000025732
ORAI calcium release-activated calcium modulator 3
chr12_+_2180150 5.64 ENSRNOT00000001322
syntaxin binding protein 2
chr13_+_5480150 5.61 ENSRNOT00000057873

chr1_+_84044551 5.56 ENSRNOT00000028290
coenzyme Q8B
chr1_-_43638161 5.50 ENSRNOT00000024460
interaction protein for cytohesin exchange factors 1
chr1_-_146289465 5.47 ENSRNOT00000017362
abhydrolase domain containing 17C
chr10_+_56576428 5.44 ENSRNOT00000079237
ENSRNOT00000023291
claudin 7
chrX_-_72370044 5.43 ENSRNOT00000004224
histone deacetylase 8
chr5_-_150704117 5.43 ENSRNOT00000067455
sestrin 2
chr17_-_78812111 5.39 ENSRNOT00000021506
DNA cross-link repair 1C
chr10_+_43744882 5.36 ENSRNOT00000078662
zinc finger protein 692
chr16_-_19376776 5.25 ENSRNOT00000020748
RAB8A, member RAS oncogene family
chr4_-_60548021 5.09 ENSRNOT00000065546

chr4_+_170149029 5.04 ENSRNOT00000073287
histone H2A.J
chr16_+_26483463 4.97 ENSRNOT00000079010
actin, cytoplasmic 2-like
chr10_-_40657861 4.92 ENSRNOT00000058665
FAT atypical cadherin 2
chr10_-_57275708 4.87 ENSRNOT00000005370
profilin 1
chr4_-_118595580 4.79 ENSRNOT00000024436
annexin A4
chr14_-_62646110 4.77 ENSRNOT00000002992
glucosamine-6-phosphate deaminase 2
chr19_+_37260469 4.76 ENSRNOT00000021362
engulfment and cell motility 3
chr1_+_13595295 4.71 ENSRNOT00000079250
NHS-like 1
chr3_+_45277348 4.46 ENSRNOT00000059246
plakophilin 4
chr3_-_120106697 4.44 ENSRNOT00000020354
prominin 2
chr3_-_9807328 4.44 ENSRNOT00000064660
torsin family 1, member A
chr3_+_122114108 4.41 ENSRNOT00000091935
signal-regulatory protein alpha
chr17_-_44520240 4.23 ENSRNOT00000086538
histone cluster 1 H2B family member h
chr11_+_82680253 4.18 ENSRNOT00000077119
ENSRNOT00000075512
lipase H
chr6_+_126170911 4.17 ENSRNOT00000077477
Ras and Rab interactor 3
chr6_+_126170720 4.15 ENSRNOT00000065246
Ras and Rab interactor 3
chr10_-_15211325 4.04 ENSRNOT00000027083
ras homolog family member T2
chr8_+_49378644 3.96 ENSRNOT00000007588
junction adhesion molecule like
chr1_+_85386470 3.91 ENSRNOT00000093332
ENSRNOT00000044326
pleckstrin homology and RhoGEF domain containing G2
chr3_+_113131327 3.83 ENSRNOT00000018460
tubulin, gamma complex associated protein 4
chr2_+_124400679 3.82 ENSRNOT00000058495
ENSRNOT00000067034
sprouty RTK signaling antagonist 1
chr8_+_133210473 3.81 ENSRNOT00000082774
chemokine (C-C motif) receptor 5
chr2_-_210873024 3.76 ENSRNOT00000026051
adenosine monophosphate deaminase 2
chrX_-_1741701 3.75 ENSRNOT00000031115
ubiquitin-like modifier activating enzyme 1
chr12_-_22021851 3.72 ENSRNOT00000039280
TSC22 domain family, member 4
chr1_-_84168044 3.71 ENSRNOT00000084586
ENSRNOT00000028348
Sh3kbp1 binding protein 1
chr17_+_44520537 3.70 ENSRNOT00000077985
histone cluster 1, H2ai-like2
chr3_+_66673246 3.67 ENSRNOT00000081338
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr5_+_122647281 3.66 ENSRNOT00000066041
mesoderm induction early response 1, transcriptional regulator
chr4_+_140247313 3.59 ENSRNOT00000040255
ENSRNOT00000064025
ENSRNOT00000041130
ENSRNOT00000043646
inositol 1,4,5-trisphosphate receptor, type 1
chr19_+_43392085 3.57 ENSRNOT00000023854
splicing factor 3b, subunit 3
chr3_+_164665532 3.51 ENSRNOT00000014309
protein tyrosine phosphatase, non-receptor type 1
chr7_+_2458264 3.50 ENSRNOT00000003550
nascent polypeptide-associated complex alpha subunit
chr2_+_225827504 3.46 ENSRNOT00000018343
glutamate cysteine ligase, modifier subunit
chr11_-_33003021 3.45 ENSRNOT00000084134
runt-related transcription factor 1
chr17_-_21739408 3.45 ENSRNOT00000060335
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme
chr2_+_196013799 3.35 ENSRNOT00000084023
pogo transposable element with ZNF domain
chr18_-_24397551 3.34 ENSRNOT00000023032
solute carrier family 25, member 46
chr10_-_65437143 3.31 ENSRNOT00000017264
NIMA-related kinase 8
chr5_+_35991068 3.30 ENSRNOT00000061139
PNN interacting serine and arginine rich protein
chr1_-_134867001 3.29 ENSRNOT00000090149
chromodomain helicase DNA binding protein 2
chrX_-_70461553 3.24 ENSRNOT00000076110
ENSRNOT00000003872
ENSRNOT00000076812
PDZ domain containing 11
chr14_+_77079402 3.23 ENSRNOT00000042200
solute carrier family 2 member 9
chr3_+_2462466 3.21 ENSRNOT00000014087
ring finger protein 208
chr18_-_69671199 3.19 ENSRNOT00000082484
SMAD family member 4
chr16_-_2367253 3.19 ENSRNOT00000083573
phosphodiesterase 12
chr10_-_97647822 3.16 ENSRNOT00000065781

chr15_+_34352914 3.15 ENSRNOT00000067150
guanosine monophosphate reductase 2
chr14_-_106393670 3.13 ENSRNOT00000011429
malate dehydrogenase 1
chr19_+_44164935 3.12 ENSRNOT00000048998
GABA type A receptor associated protein like 2
chr4_+_66091641 3.11 ENSRNOT00000043147

chrX_-_71127237 3.08 ENSRNOT00000076403
ENSRNOT00000076635
ENSRNOT00000068098
sorting nexin 12
chr10_-_56289882 3.08 ENSRNOT00000090762
ENSRNOT00000056903
tumor necrosis factor superfamily member 13
chrX_+_70461718 3.06 ENSRNOT00000078233
ENSRNOT00000003789
kinesin family member 4A
chr7_+_63922879 3.06 ENSRNOT00000043581
similar to Hypothetical protein LOC270802
chr3_+_66673071 2.99 ENSRNOT00000034769
protein phosphatase 1, regulatory (inhibitor) subunit 1C
chr16_-_74264142 2.99 ENSRNOT00000026067
dickkopf WNT signaling pathway inhibitor 4
chr15_-_34469350 2.96 ENSRNOT00000067536
adenylate cyclase 4
chr5_+_16526058 2.96 ENSRNOT00000011130
LYN proto-oncogene, Src family tyrosine kinase
chr5_-_136726358 2.90 ENSRNOT00000026739
DPH2 homolog
chr15_-_32888095 2.88 ENSRNOT00000012233
defender against cell death 1
chr6_+_43363792 2.86 ENSRNOT00000091061
cleavage and polyadenylation specific factor 3
chr1_+_86972244 2.78 ENSRNOT00000036907
Ras and Rab interactor-like
chr14_+_104475082 2.77 ENSRNOT00000084481
RAB1A, member RAS oncogene family
chr1_-_221015929 2.75 ENSRNOT00000028137
signal-induced proliferation-associated 1
chr18_+_24397369 2.74 ENSRNOT00000022761
Sin3A associated protein 130
chr3_-_162579201 2.72 ENSRNOT00000068328
zinc finger, MYND-type containing 8
chr10_+_58342393 2.72 ENSRNOT00000010358
WSC domain containing 1
chr1_+_221409271 2.69 ENSRNOT00000028462
synoviolin 1
chr7_-_122581777 2.68 ENSRNOT00000025758
solute carrier family 25 member 17
chr10_-_13892997 2.61 ENSRNOT00000004192
TNF receptor associated factor 7
chr6_+_26836216 2.61 ENSRNOT00000077903
ENSRNOT00000011373
oligosaccharyltransferase complex subunit 4, non-catalytic
chr10_+_85978691 2.60 ENSRNOT00000006359
ribosomal protein L19
chr16_-_2367069 2.59 ENSRNOT00000079625
phosphodiesterase 12
chr5_+_154260062 2.56 ENSRNOT00000074998
cannabinoid receptor 2
chr3_-_3890758 2.56 ENSRNOT00000064083
SEC16 homolog A, endoplasmic reticulum export factor
chr10_-_30118873 2.54 ENSRNOT00000006063
ubiquitin-like domain containing CTD phosphatase 1
chr16_+_20825044 2.50 ENSRNOT00000027268
UPF1, RNA helicase and ATPase
chr10_-_110585376 2.46 ENSRNOT00000054917
Rab40b, member RAS oncogene family
chr7_-_12085226 2.46 ENSRNOT00000088669
ENSRNOT00000079925
one cut domain, family member 3
chr20_-_4818568 2.46 ENSRNOT00000001115
DExD-box helicase 39B
chr10_+_59360765 2.44 ENSRNOT00000036278
zinc finger ZZ-type and EF-hand domain containing 1
chr10_+_74002151 2.44 ENSRNOT00000005661
peptidyl-tRNA hydrolase 2
chr2_-_187786700 2.41 ENSRNOT00000092257
ENSRNOT00000092612
ENSRNOT00000068360
solute carrier family 25, member 44
chr3_-_152222647 2.34 ENSRNOT00000026820
NFS1 cysteine desulfurase
chr1_-_222098297 2.27 ENSRNOT00000028678
ribosomal protein S6 kinase A4
chr5_-_173653905 2.22 ENSRNOT00000038556
pleckstrin homology domain containing N1
chr1_-_82409639 2.22 ENSRNOT00000031326
glutamate-rich 4
chr2_-_189602143 2.15 ENSRNOT00000032062
cAMP responsive element binding protein 3-like 4
chr5_-_171710312 2.14 ENSRNOT00000076044
ENSRNOT00000071280
ENSRNOT00000072059
ENSRNOT00000077015
PR/SET domain 16
chr1_+_12823363 2.14 ENSRNOT00000086790
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr6_+_104291340 2.13 ENSRNOT00000089313
solute carrier family 39, member 9
chr1_+_142060955 2.10 ENSRNOT00000017862
VPS33B, late endosome and lysosome associated
chr2_-_78283473 2.03 ENSRNOT00000087246

chr13_+_35554964 2.03 ENSRNOT00000072632
transmembrane protein 185B
chr7_-_60309878 2.00 ENSRNOT00000007610
similar to RIKEN cDNA 9530003J23
chr20_+_5646097 1.96 ENSRNOT00000090925
inositol 1,4,5-trisphosphate receptor, type 3
chr3_-_151688149 1.89 ENSRNOT00000072945
NFS1 cysteine desulfurase
chr7_+_12471824 1.89 ENSRNOT00000068197
strawberry notch homolog 2
chr20_+_2094931 1.84 ENSRNOT00000001013
protein phosphatase 1, regulatory (inhibitor) subunit 11
chr18_+_40586315 1.83 ENSRNOT00000041237
eukaryotic translation initiation factor 1A
chr1_-_7801438 1.82 ENSRNOT00000022273

chr13_+_56513286 1.80 ENSRNOT00000015596
zinc finger and BTB domain containing 41
chr9_+_9704346 1.77 ENSRNOT00000075403
G protein-coupled receptor 108
chr10_+_55924938 1.68 ENSRNOT00000087003
ENSRNOT00000057079
trafficking protein particle complex 1
chr3_+_122544788 1.68 ENSRNOT00000063828
transglutaminase 3
chr8_+_49354115 1.66 ENSRNOT00000032837
myelin protein zero-like 3
chr10_+_89174684 1.58 ENSRNOT00000043754
vacuolar protein sorting 25
chr11_-_35749464 1.58 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr8_-_55171718 1.58 ENSRNOT00000080736
hypothetical protein LOC689959
chr5_+_120498883 1.53 ENSRNOT00000007859
leptin receptor overlapping transcript
chr18_+_1971506 1.51 ENSRNOT00000092027
mindbomb E3 ubiquitin protein ligase 1
chr11_+_46184871 1.50 ENSRNOT00000048417
Trk-fused gene
chr13_+_82231030 1.50 ENSRNOT00000003551
SCY1 like pseudokinase 3
chr7_-_3246071 1.44 ENSRNOT00000044292
ORMDL sphingolipid biosynthesis regulator 2
chr18_-_27159693 1.37 ENSRNOT00000027345
receptor accessory protein 5
chr17_-_63994169 1.37 ENSRNOT00000075651
cholinergic receptor, muscarinic 3
chr17_-_90071408 1.34 ENSRNOT00000071978
decaprenyl diphosphate synthase subunit 1
chr9_+_114022137 1.32 ENSRNOT00000007657
mitogen activated protein kinase kinase kinase 7
chr19_-_37528011 1.31 ENSRNOT00000059628
agouti related neuropeptide
chr18_-_40586260 1.30 ENSRNOT00000004942
transmembrane p24 trafficking protein 7
chr10_+_43768708 1.28 ENSRNOT00000086218
SH3 binding domain protein 5 like
chr17_-_10001901 1.25 ENSRNOT00000082836
fibroblast growth factor receptor 4
chr7_-_140919234 1.23 ENSRNOT00000082470
microspherule protein 1
chr2_+_198006316 1.23 ENSRNOT00000081383
ENSRNOT00000056289
aph-1 homolog A, gamma secretase subunit
chr3_-_122703705 1.20 ENSRNOT00000079923
ENSRNOT00000049857
small nuclear ribonucleoprotein polypeptides B and B1
chr8_-_64154396 1.20 ENSRNOT00000031262
Bardet-Biedl syndrome 4
chr10_+_46818525 1.16 ENSRNOT00000088120
developmentally regulated GTP binding protein 2
chr1_-_260517323 1.16 ENSRNOT00000018043
transmembrane 9 superfamily member 3
chr17_+_45078556 1.15 ENSRNOT00000088280
zinc finger protein 192
chr1_-_65664767 1.14 ENSRNOT00000026528
ENSRNOT00000088367
ribosomal protein S5
chr17_+_81209867 1.11 ENSRNOT00000077368
ENSRNOT00000087129
signal transducing adaptor molecule
chr10_-_16792909 1.11 ENSRNOT00000004653
ATPase H+ transporting V0 subunit e1
chr1_+_221735517 1.09 ENSRNOT00000028628
ENSRNOT00000044866
splicing factor 1
chr5_-_139748489 1.04 ENSRNOT00000078741
nuclear transcription factor Y subunit gamma
chr5_-_140585408 1.04 ENSRNOT00000018711
adenylate cyclase associated protein 1
chr3_-_59688692 1.03 ENSRNOT00000078752
Sp3 transcription factor
chr10_+_47018974 0.99 ENSRNOT00000079375
Smith-Magenis syndrome chromosome region, candidate 8
chr6_+_108936664 0.98 ENSRNOT00000007298
dihydrolipoamide S-succinyltransferase
chr2_-_178389608 0.92 ENSRNOT00000013262
electron transfer flavoprotein dehydrogenase
chrX_+_10964067 0.91 ENSRNOT00000093181
ENSRNOT00000066480
mediator complex subunit 14
chr18_+_25037625 0.90 ENSRNOT00000018422
ERCC excision repair 3, TFIIH core complex helicase subunit
chr12_+_47103314 0.90 ENSRNOT00000064910
ring finger protein 10

Network of associatons between targets according to the STRING database.

First level regulatory network of Spdef

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
6.2 18.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
3.3 13.2 GO:0032687 negative regulation of interferon-alpha production(GO:0032687)
2.7 8.2 GO:0002432 granuloma formation(GO:0002432)
2.7 10.9 GO:0051692 cellular oligosaccharide catabolic process(GO:0051692) regulation of exo-alpha-sialidase activity(GO:1903015)
2.5 9.8 GO:0071226 cellular response to molecule of fungal origin(GO:0071226)
2.1 6.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
2.1 12.3 GO:0002457 T cell antigen processing and presentation(GO:0002457)
2.0 5.9 GO:2000422 regulation of eosinophil chemotaxis(GO:2000422) positive regulation of eosinophil chemotaxis(GO:2000424)
1.8 5.4 GO:0071921 establishment of sister chromatid cohesion(GO:0034085) cohesin loading(GO:0071921) regulation of cohesin loading(GO:0071922)
1.8 7.2 GO:0045658 regulation of neutrophil differentiation(GO:0045658)
1.7 5.2 GO:0048210 Golgi vesicle fusion to target membrane(GO:0048210)
1.5 5.9 GO:0002084 protein depalmitoylation(GO:0002084)
1.5 7.4 GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316)
1.5 8.7 GO:1990086 lens fiber cell apoptotic process(GO:1990086)
1.4 4.2 GO:0018283 metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283)
1.4 5.4 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
1.3 4.0 GO:0035696 monocyte extravasation(GO:0035696)
1.3 3.8 GO:0060939 cardiac fibroblast cell differentiation(GO:0060935) cardiac fibroblast cell development(GO:0060936) epicardium-derived cardiac fibroblast cell differentiation(GO:0060938) epicardium-derived cardiac fibroblast cell development(GO:0060939)
1.3 3.8 GO:2000464 positive regulation of astrocyte chemotaxis(GO:2000464)
1.2 3.5 GO:1901227 negative regulation of transcription from RNA polymerase II promoter involved in heart development(GO:1901227)
1.2 3.5 GO:2000872 positive regulation of progesterone secretion(GO:2000872)
1.1 3.3 GO:0090149 mitochondrial membrane fission(GO:0090149)
1.1 21.7 GO:0097284 hepatocyte apoptotic process(GO:0097284)
1.1 14.0 GO:0006968 cellular defense response(GO:0006968)
1.1 3.2 GO:0035262 left ventricular cardiac muscle tissue morphogenesis(GO:0003220) cell proliferation involved in heart valve morphogenesis(GO:0003249) regulation of cell proliferation involved in heart valve morphogenesis(GO:0003250) gonad morphogenesis(GO:0035262) nephrogenic mesenchyme morphogenesis(GO:0072134)
1.0 13.8 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
1.0 3.0 GO:0060369 positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.9 5.5 GO:0038096 immune response-regulating cell surface receptor signaling pathway involved in phagocytosis(GO:0002433) Fc-gamma receptor signaling pathway involved in phagocytosis(GO:0038096)
0.9 2.7 GO:0042631 cellular response to water deprivation(GO:0042631)
0.9 2.7 GO:0043132 NAD transport(GO:0043132)
0.9 4.4 GO:0048550 negative regulation of pinocytosis(GO:0048550)
0.9 3.5 GO:1902202 regulation of hepatocyte growth factor receptor signaling pathway(GO:1902202) negative regulation of PERK-mediated unfolded protein response(GO:1903898)
0.9 3.5 GO:0097069 cellular response to thyroxine stimulus(GO:0097069)
0.8 10.8 GO:0002467 germinal center formation(GO:0002467)
0.8 2.5 GO:0000294 nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay(GO:0000294)
0.7 7.4 GO:0070995 NADPH oxidation(GO:0070995)
0.7 8.4 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.7 4.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.7 2.7 GO:1903756 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
0.7 5.4 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.7 0.7 GO:0034724 DNA replication-independent nucleosome organization(GO:0034724)
0.6 3.8 GO:0051418 interphase microtubule nucleation by interphase microtubule organizing center(GO:0051415) microtubule nucleation by microtubule organizing center(GO:0051418)
0.6 4.4 GO:0051940 regulation of dopamine uptake involved in synaptic transmission(GO:0051584) regulation of catecholamine uptake involved in synaptic transmission(GO:0051940) nuclear membrane organization(GO:0071763)
0.6 1.9 GO:0071348 cellular response to interleukin-11(GO:0071348)
0.6 3.8 GO:0032264 IMP salvage(GO:0032264)
0.6 3.1 GO:0000022 mitotic spindle elongation(GO:0000022) mitotic spindle midzone assembly(GO:0051256)
0.6 2.9 GO:0017182 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
0.6 2.3 GO:0043988 histone H3-S10 phosphorylation(GO:0043987) histone H3-S28 phosphorylation(GO:0043988)
0.5 8.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.5 3.2 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.5 6.8 GO:0098719 sodium ion import across plasma membrane(GO:0098719) sodium ion import into cell(GO:1990118)
0.5 2.6 GO:1903336 negative regulation of vacuolar transport(GO:1903336)
0.5 4.6 GO:0070236 negative regulation of activation-induced cell death of T cells(GO:0070236)
0.5 3.0 GO:0036438 maintenance of lens transparency(GO:0036438)
0.5 4.9 GO:1900029 positive regulation of ruffle assembly(GO:1900029)
0.5 1.4 GO:1900060 negative regulation of ceramide biosynthetic process(GO:1900060)
0.5 1.4 GO:0043309 regulation of eosinophil degranulation(GO:0043309) positive regulation of eosinophil degranulation(GO:0043311) positive regulation of eosinophil activation(GO:1902568)
0.5 2.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.4 3.1 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
0.4 8.0 GO:0038065 collagen-activated signaling pathway(GO:0038065)
0.4 7.8 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.4 6.9 GO:1901663 ubiquinone biosynthetic process(GO:0006744) quinone biosynthetic process(GO:1901663)
0.4 2.1 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.4 3.0 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.4 2.1 GO:0070889 platelet alpha granule organization(GO:0070889)
0.4 5.4 GO:0016338 calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) negative regulation of protein homooligomerization(GO:0032463)
0.4 3.7 GO:0031937 positive regulation of chromatin silencing(GO:0031937)
0.4 5.6 GO:0043312 neutrophil degranulation(GO:0043312)
0.4 3.3 GO:0035330 regulation of hippo signaling(GO:0035330)
0.4 2.5 GO:2000002 negative regulation of DNA damage checkpoint(GO:2000002)
0.3 2.4 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 5.9 GO:0071397 cellular response to cholesterol(GO:0071397)
0.3 2.8 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.3 1.0 GO:0033512 L-lysine catabolic process to acetyl-CoA via saccharopine(GO:0033512)
0.3 1.2 GO:0007037 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
0.3 1.2 GO:0038108 negative regulation of appetite by leptin-mediated signaling pathway(GO:0038108)
0.3 0.9 GO:0071336 regulation of hair follicle cell proliferation(GO:0071336)
0.3 2.6 GO:0038171 cannabinoid signaling pathway(GO:0038171)
0.3 2.6 GO:0048207 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.3 3.3 GO:0051382 kinetochore assembly(GO:0051382)
0.3 1.6 GO:0003199 endocardial cushion to mesenchymal transition involved in heart valve formation(GO:0003199) positive regulation of blood vessel remodeling(GO:2000504)
0.3 3.1 GO:0006108 malate metabolic process(GO:0006108)
0.3 5.9 GO:0002115 store-operated calcium entry(GO:0002115)
0.3 4.8 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.3 1.8 GO:1901098 positive regulation of autophagosome maturation(GO:1901098)
0.2 0.7 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
0.2 0.7 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.2 2.1 GO:0030853 negative regulation of granulocyte differentiation(GO:0030853) positive regulation of brown fat cell differentiation(GO:0090336)
0.2 3.1 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.2 4.4 GO:0006910 phagocytosis, recognition(GO:0006910)
0.2 1.3 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 10.5 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.2 1.2 GO:1904751 positive regulation of protein localization to nucleolus(GO:1904751)
0.2 6.7 GO:1900087 positive regulation of G1/S transition of mitotic cell cycle(GO:1900087)
0.2 3.2 GO:0046415 urate metabolic process(GO:0046415)
0.2 6.8 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 11.1 GO:0032611 interleukin-1 beta production(GO:0032611)
0.2 5.8 GO:0090503 RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503)
0.2 0.9 GO:0010626 negative regulation of Schwann cell proliferation(GO:0010626)
0.2 10.7 GO:0038083 peptidyl-tyrosine autophosphorylation(GO:0038083)
0.2 4.0 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.2 5.7 GO:0033198 response to ATP(GO:0033198)
0.2 1.0 GO:0060136 embryonic process involved in female pregnancy(GO:0060136)
0.2 3.3 GO:0060218 hematopoietic stem cell differentiation(GO:0060218)
0.2 2.6 GO:0000185 activation of MAPKKK activity(GO:0000185)
0.2 3.2 GO:0046037 GMP metabolic process(GO:0046037)
0.2 0.5 GO:0016476 regulation of embryonic cell shape(GO:0016476)
0.2 1.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.1 0.4 GO:0038086 VEGF-activated platelet-derived growth factor receptor signaling pathway(GO:0038086) positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway(GO:0038091)
0.1 4.5 GO:0032467 positive regulation of cytokinesis(GO:0032467)
0.1 1.2 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
0.1 0.7 GO:2000622 regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000622) negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:2000623)
0.1 0.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
0.1 0.8 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 3.7 GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway(GO:0045742)
0.1 2.7 GO:1902236 negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway(GO:1902236)
0.1 8.7 GO:0006342 chromatin silencing(GO:0006342)
0.1 0.9 GO:0033683 UV protection(GO:0009650) nucleotide-excision repair, DNA incision(GO:0033683)
0.1 0.9 GO:0035542 regulation of SNARE complex assembly(GO:0035542)
0.1 1.7 GO:0031424 keratinization(GO:0031424)
0.1 0.6 GO:0001842 neural fold formation(GO:0001842)
0.1 1.1 GO:0030575 nuclear body organization(GO:0030575)
0.1 1.8 GO:0032515 negative regulation of phosphoprotein phosphatase activity(GO:0032515)
0.1 0.9 GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539)
0.1 0.5 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.1 0.7 GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation(GO:0034315)
0.1 3.0 GO:0006182 cGMP biosynthetic process(GO:0006182)
0.1 0.4 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.1 2.5 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 1.4 GO:0045987 positive regulation of smooth muscle contraction(GO:0045987)
0.1 3.2 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 1.1 GO:0006450 regulation of translational fidelity(GO:0006450)
0.1 1.3 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 28.0 GO:0043547 positive regulation of GTPase activity(GO:0043547)
0.0 3.1 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 2.6 GO:0097421 liver regeneration(GO:0097421)
0.0 0.1 GO:1990166 protein localization to site of double-strand break(GO:1990166)
0.0 4.2 GO:0006334 nucleosome assembly(GO:0006334)
0.0 2.9 GO:0001824 blastocyst development(GO:0001824)
0.0 4.8 GO:0006909 phagocytosis(GO:0006909)
0.0 1.3 GO:0006829 zinc II ion transport(GO:0006829)
0.0 1.2 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
0.0 0.1 GO:2001185 regulation of CD8-positive, alpha-beta T cell activation(GO:2001185)
0.0 1.5 GO:0001947 heart looping(GO:0001947)
0.0 1.1 GO:0034620 endoplasmic reticulum unfolded protein response(GO:0030968) cellular response to unfolded protein(GO:0034620)
0.0 0.7 GO:0046329 negative regulation of JNK cascade(GO:0046329)
0.0 0.6 GO:0051491 positive regulation of filopodium assembly(GO:0051491)
0.0 0.2 GO:0006265 DNA topological change(GO:0006265)
0.0 0.8 GO:0042220 response to cocaine(GO:0042220)
0.0 1.0 GO:0045761 regulation of adenylate cyclase activity(GO:0045761)
0.0 0.6 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.0 0.3 GO:0006105 succinate metabolic process(GO:0006105)
0.0 0.1 GO:2000435 regulation of protein neddylation(GO:2000434) negative regulation of protein neddylation(GO:2000435)
0.0 1.7 GO:0042303 molting cycle(GO:0042303) hair cycle(GO:0042633)
0.0 0.4 GO:0035066 positive regulation of histone acetylation(GO:0035066)
0.0 3.9 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 2.7 GO:0042113 B cell activation(GO:0042113)
0.0 0.4 GO:0021511 spinal cord patterning(GO:0021511)
0.0 1.5 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.2 GO:0006622 protein targeting to lysosome(GO:0006622)
0.0 1.1 GO:0043200 response to amino acid(GO:0043200)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.2 6.6 GO:0030690 Noc1p-Noc2p complex(GO:0030690)
1.4 8.2 GO:0033093 Weibel-Palade body(GO:0033093)
1.1 4.4 GO:0044393 microspike(GO:0044393) prominosome(GO:0071914)
1.1 3.3 GO:0097543 ciliary inversin compartment(GO:0097543)
1.1 3.2 GO:1902560 GMP reductase complex(GO:1902560)
1.0 9.9 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
1.0 3.0 GO:0034666 integrin alpha2-beta1 complex(GO:0034666)
0.9 7.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.9 2.7 GO:0000839 Hrd1p ubiquitin ligase ERAD-L complex(GO:0000839)
0.9 3.6 GO:0031088 platelet dense granule membrane(GO:0031088)
0.7 13.5 GO:0042589 zymogen granule membrane(GO:0042589)
0.6 3.8 GO:0000923 equatorial microtubule organizing center(GO:0000923)
0.6 4.4 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.5 3.2 GO:0032444 activin responsive factor complex(GO:0032444)
0.5 1.6 GO:0000814 ESCRT II complex(GO:0000814)
0.5 2.5 GO:0044530 supraspliceosomal complex(GO:0044530)
0.5 16.3 GO:0034451 centriolar satellite(GO:0034451)
0.5 7.4 GO:0044224 juxtaparanode region of axon(GO:0044224)
0.5 2.7 GO:0030914 STAGA complex(GO:0030914)
0.4 2.3 GO:0000322 storage vacuole(GO:0000322)
0.4 1.4 GO:0035339 SPOTS complex(GO:0035339)
0.4 8.2 GO:0030057 desmosome(GO:0030057)
0.3 3.1 GO:0070419 nonhomologous end joining complex(GO:0070419)
0.3 5.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.3 3.7 GO:0005687 U4 snRNP(GO:0005687)
0.3 5.9 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 5.4 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.2 10.7 GO:0000791 euchromatin(GO:0000791)
0.2 1.2 GO:0034455 t-UTP complex(GO:0034455)
0.2 3.0 GO:0030897 HOPS complex(GO:0030897)
0.2 6.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.2 0.7 GO:0035101 FACT complex(GO:0035101)
0.2 6.1 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.2 1.0 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
0.2 2.9 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.2 10.5 GO:0034707 chloride channel complex(GO:0034707)
0.2 5.7 GO:0030131 clathrin adaptor complex(GO:0030131)
0.2 3.6 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.2 8.4 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.2 3.5 GO:0000421 autophagosome membrane(GO:0000421)
0.2 0.9 GO:0070847 core mediator complex(GO:0070847)
0.1 1.7 GO:0030008 TRAPP complex(GO:0030008)
0.1 1.8 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 11.4 GO:0000786 nucleosome(GO:0000786)
0.1 2.3 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.1 1.3 GO:0005796 Golgi lumen(GO:0005796)
0.1 3.0 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.1 13.5 GO:0005884 actin filament(GO:0005884)
0.1 0.9 GO:0000439 core TFIIH complex(GO:0000439)
0.1 24.1 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 0.5 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
0.1 0.6 GO:0071986 Ragulator complex(GO:0071986)
0.1 1.1 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 0.3 GO:0045283 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) fumarate reductase complex(GO:0045283)
0.1 1.2 GO:0031011 Ino80 complex(GO:0031011) DNA helicase complex(GO:0033202)
0.1 8.1 GO:0090575 RNA polymerase II transcription factor complex(GO:0090575)
0.1 0.8 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.0 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 1.3 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.1 0.8 GO:0005662 DNA replication factor A complex(GO:0005662)
0.1 6.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 3.1 GO:0045171 intercellular bridge(GO:0045171)
0.1 6.9 GO:0005604 basement membrane(GO:0005604)
0.1 0.4 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.1 0.7 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 1.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 11.5 GO:0005667 transcription factor complex(GO:0005667)
0.0 6.4 GO:0055037 recycling endosome(GO:0055037)
0.0 0.2 GO:0070765 gamma-secretase complex(GO:0070765)
0.0 0.7 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 9.2 GO:0005769 early endosome(GO:0005769)
0.0 4.9 GO:0072562 blood microparticle(GO:0072562)
0.0 0.4 GO:0043202 lysosomal lumen(GO:0043202)
0.0 4.0 GO:0005923 bicellular tight junction(GO:0005923)
0.0 3.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.9 GO:0031305 intrinsic component of mitochondrial inner membrane(GO:0031304) integral component of mitochondrial inner membrane(GO:0031305)
0.0 6.9 GO:0009897 external side of plasma membrane(GO:0009897)
0.0 0.5 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.0 4.6 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 0.5 GO:0044447 axoneme part(GO:0044447)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 0.1 GO:0000815 ESCRT III complex(GO:0000815)
0.0 2.5 GO:0043209 myelin sheath(GO:0043209)
0.0 0.8 GO:0000792 heterochromatin(GO:0000792)
0.0 3.8 GO:0005635 nuclear envelope(GO:0005635)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 10.9 GO:0017042 glycosylceramidase activity(GO:0017042)
2.1 18.5 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
1.8 7.2 GO:0016312 inositol bisphosphate phosphatase activity(GO:0016312) PTB domain binding(GO:0051425)
1.7 6.6 GO:0035877 death effector domain binding(GO:0035877)
1.5 7.7 GO:0030348 syntaxin-3 binding(GO:0030348)
1.4 5.5 GO:0005220 inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
1.3 3.8 GO:0071791 chemokine (C-C motif) ligand 5 binding(GO:0071791)
1.2 3.7 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
1.1 7.8 GO:0035375 zymogen binding(GO:0035375)
1.1 8.7 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
1.1 6.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
1.1 8.5 GO:0004865 protein serine/threonine phosphatase inhibitor activity(GO:0004865)
1.1 3.2 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.9 3.8 GO:0047623 AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623)
0.9 5.4 GO:0070728 leucine binding(GO:0070728)
0.8 5.9 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
0.8 8.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
0.8 3.1 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.8 5.4 GO:0035312 5'-3' exodeoxyribonuclease activity(GO:0035312)
0.7 15.1 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.7 6.8 GO:0015386 potassium:proton antiporter activity(GO:0015386)
0.7 13.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.6 2.6 GO:0004949 cannabinoid receptor activity(GO:0004949)
0.6 2.4 GO:0004045 aminoacyl-tRNA hydrolase activity(GO:0004045)
0.6 12.3 GO:0043274 phospholipase binding(GO:0043274)
0.6 10.5 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.5 9.8 GO:0008329 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.5 12.8 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.5 2.6 GO:1990932 5.8S rRNA binding(GO:1990932)
0.5 7.4 GO:0071933 Arp2/3 complex binding(GO:0071933)
0.5 4.9 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.5 1.4 GO:0016230 sphingomyelin phosphodiesterase activator activity(GO:0016230)
0.5 4.8 GO:0016861 intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861)
0.4 5.4 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.4 3.6 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.4 1.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.4 3.2 GO:0043199 sulfate binding(GO:0043199)
0.4 4.2 GO:0016783 sulfurtransferase activity(GO:0016783)
0.4 11.1 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.4 10.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.3 3.8 GO:0051011 microtubule minus-end binding(GO:0051011)
0.3 5.8 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.3 7.4 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.3 3.0 GO:0043208 glycosphingolipid binding(GO:0043208)
0.3 5.9 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.3 1.0 GO:0016748 succinyltransferase activity(GO:0016748)
0.3 3.2 GO:0015143 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.3 2.5 GO:0030621 U6 snRNA binding(GO:0017070) U4 snRNA binding(GO:0030621)
0.3 1.5 GO:0051185 coenzyme transporter activity(GO:0051185)
0.3 2.7 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 0.9 GO:0032427 GBD domain binding(GO:0032427)
0.3 4.4 GO:0051787 misfolded protein binding(GO:0051787)
0.3 14.3 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.3 0.8 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.2 8.4 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 10.3 GO:0015485 cholesterol binding(GO:0015485)
0.2 5.2 GO:0031489 myosin V binding(GO:0031489)
0.2 9.1 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
0.2 2.9 GO:0004576 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.2 1.2 GO:0048039 ubiquinone binding(GO:0048039)
0.2 3.1 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 10.7 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.2 1.8 GO:0043023 ribosomal large subunit binding(GO:0043023)
0.2 0.9 GO:0032564 dATP binding(GO:0032564)
0.2 1.2 GO:0002151 G-quadruplex RNA binding(GO:0002151) telomerase inhibitor activity(GO:0010521)
0.2 1.7 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.2 7.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.2 3.5 GO:0016881 acid-amino acid ligase activity(GO:0016881)
0.2 1.2 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.2 2.0 GO:0003796 lysozyme activity(GO:0003796)
0.1 1.2 GO:0034452 dynactin binding(GO:0034452)
0.1 0.4 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 2.2 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.8 GO:0010385 double-stranded methylated DNA binding(GO:0010385)
0.1 4.4 GO:0045309 protein phosphorylated amino acid binding(GO:0045309)
0.1 3.4 GO:0005158 insulin receptor binding(GO:0005158)
0.1 2.7 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 3.0 GO:0004383 guanylate cyclase activity(GO:0004383)
0.1 1.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 8.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)
0.1 0.7 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.1 4.8 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 3.1 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 1.0 GO:0008179 adenylate cyclase binding(GO:0008179)
0.1 23.2 GO:0005096 GTPase activator activity(GO:0005096)
0.1 2.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.1 1.4 GO:0042166 acetylcholine binding(GO:0042166)
0.1 7.7 GO:0017137 Rab GTPase binding(GO:0017137)
0.1 2.5 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 4.2 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.1 0.7 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
0.1 3.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.7 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.0 5.4 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.7 GO:0008143 poly(A) binding(GO:0008143)
0.0 2.1 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 4.2 GO:0004620 phospholipase activity(GO:0004620)
0.0 1.3 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 4.8 GO:0017124 SH3 domain binding(GO:0017124)
0.0 2.7 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 2.5 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.2 GO:0003917 DNA topoisomerase type I activity(GO:0003917)
0.0 3.0 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 1.0 GO:0017025 TBP-class protein binding(GO:0017025)
0.0 6.5 GO:0001047 core promoter binding(GO:0001047)
0.0 5.5 GO:0019902 phosphatase binding(GO:0019902)
0.0 4.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 0.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 13.4 GO:0046982 protein heterodimerization activity(GO:0046982)
0.0 0.7 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 12.1 GO:0000976 transcription regulatory region sequence-specific DNA binding(GO:0000976)
0.0 0.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 5.1 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
0.0 0.9 GO:0019905 syntaxin binding(GO:0019905)
0.0 12.0 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.8 GO:0005178 integrin binding(GO:0005178)
0.0 1.3 GO:0044212 transcription regulatory region DNA binding(GO:0044212)
0.0 2.3 GO:0000287 magnesium ion binding(GO:0000287)
0.0 1.2 GO:0005525 GTP binding(GO:0005525)
0.0 0.4 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 5.5 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.7 6.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.7 13.8 PID DNA PK PATHWAY DNA-PK pathway in nonhomologous end joining
0.7 40.7 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.6 6.8 ST JAK STAT PATHWAY Jak-STAT Pathway
0.5 8.7 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.3 4.5 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 3.2 PID ALK2 PATHWAY ALK2 signaling events
0.2 1.3 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 11.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.2 11.1 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.2 3.5 PID IGF1 PATHWAY IGF1 pathway
0.2 4.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.1 3.0 PID LPA4 PATHWAY LPA4-mediated signaling events
0.1 3.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 14.4 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.1 4.0 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 1.5 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.1 6.1 PID HDAC CLASSI PATHWAY Signaling events mediated by HDAC Class I
0.1 1.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 1.1 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 3.5 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 2.1 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 2.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 1.0 SIG INSULIN RECEPTOR PATHWAY IN CARDIAC MYOCYTES Genes related to the insulin receptor pathway
0.0 2.7 PID PDGFRB PATHWAY PDGFR-beta signaling pathway
0.0 5.8 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.2 PID FGF PATHWAY FGF signaling pathway
0.0 1.6 PID IL12 2PATHWAY IL12-mediated signaling events
0.0 0.7 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.0 1.5 PID NOTCH PATHWAY Notch signaling pathway
0.0 0.4 PID S1P S1P1 PATHWAY S1P1 pathway
0.0 1.0 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 3.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 3.5 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.2 PID ATM PATHWAY ATM pathway

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 18.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
1.0 3.8 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
0.6 12.3 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.6 6.6 REACTOME NFKB ACTIVATION THROUGH FADD RIP1 PATHWAY MEDIATED BY CASPASE 8 AND10 Genes involved in NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
0.5 11.7 REACTOME REGULATION OF SIGNALING BY CBL Genes involved in Regulation of signaling by CBL
0.5 8.7 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
0.4 6.9 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.4 5.9 REACTOME ROLE OF DCC IN REGULATING APOPTOSIS Genes involved in Role of DCC in regulating apoptosis
0.3 4.4 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.3 5.3 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.3 3.1 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
0.3 10.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.3 8.1 REACTOME GROWTH HORMONE RECEPTOR SIGNALING Genes involved in Growth hormone receptor signaling
0.2 5.9 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.2 3.0 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.2 3.2 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.2 11.6 REACTOME SIGNALING BY SCF KIT Genes involved in Signaling by SCF-KIT
0.2 2.7 REACTOME RAP1 SIGNALLING Genes involved in Rap1 signalling
0.2 27.6 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.2 4.2 REACTOME RNA POL I PROMOTER OPENING Genes involved in RNA Polymerase I Promoter Opening
0.2 5.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.2 1.3 REACTOME IRAK2 MEDIATED ACTIVATION OF TAK1 COMPLEX UPON TLR7 8 OR 9 STIMULATION Genes involved in IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation
0.2 2.0 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.2 1.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 7.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.1 4.1 REACTOME PROCESSING OF CAPPED INTRONLESS PRE MRNA Genes involved in Processing of Capped Intronless Pre-mRNA
0.1 2.9 REACTOME EGFR DOWNREGULATION Genes involved in EGFR downregulation
0.1 3.2 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 2.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.1 3.5 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 3.6 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 1.2 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.1 3.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.1 2.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.1 3.9 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 1.2 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.1 1.6 REACTOME FORMATION OF RNA POL II ELONGATION COMPLEX Genes involved in Formation of RNA Pol II elongation complex
0.1 1.7 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
0.1 6.8 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.0 2.3 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 4.0 REACTOME TOLL RECEPTOR CASCADES Genes involved in Toll Receptor Cascades
0.0 7.5 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.0 3.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.7 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.0 0.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.0 1.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.0 0.5 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.0 1.4 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.0 0.4 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 0.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.1 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade