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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sp100

Z-value: 0.49

Motif logo

Transcription factors associated with Sp100

Gene Symbol Gene ID Gene Info
ENSRNOG00000022769 SP100 nuclear antigen

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sp100rn6_v1_chr9_+_92681078_926810780.156.4e-03Click!

Activity profile of Sp100 motif

Sorted Z-values of Sp100 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_48372583 16.49 ENSRNOT00000040482
ENSRNOT00000077788
ENSRNOT00000085426
dipeptidylpeptidase 4
chr4_+_98337367 13.56 ENSRNOT00000042165

chr4_-_70628470 11.62 ENSRNOT00000029319
trypsin 5
chr14_+_22517774 11.50 ENSRNOT00000047655
UDP-glucuronosyltransferase 2 family, member 37
chr1_-_258877045 10.04 ENSRNOT00000071633
cytochrome P450, family 2, subfamily c, polypeptide 13
chr4_+_70755795 10.00 ENSRNOT00000043527
similar to Anionic trypsin II precursor (Pretrypsinogen II)
chr13_-_113927745 9.33 ENSRNOT00000010910
ENSRNOT00000080616
complement C3d receptor 2
chrY_+_506149 8.09 ENSRNOT00000086056
lysine demethylase 5D
chrY_+_914045 8.05 ENSRNOT00000088593
eukaryotic translation initiation factor 2, subunit 3, structural gene Y-linked
chr13_-_55173692 7.81 ENSRNOT00000064785
ENSRNOT00000029878
ENSRNOT00000029865
ENSRNOT00000060292
ENSRNOT00000000814
protein tyrosine phosphatase, receptor type, C
chr20_-_1339488 7.68 ENSRNOT00000041074
RT1 class Ib, locus M2
chr10_-_98544447 7.37 ENSRNOT00000073149
ATP binding cassette subfamily A member 6
chr4_+_154215250 7.12 ENSRNOT00000072465
murinoglobulin 2
chr7_+_28412198 6.79 ENSRNOT00000081822
ENSRNOT00000038780
ENSRNOT00000005995
insulin-like growth factor 1
chr1_-_76517134 6.78 ENSRNOT00000064593
ENSRNOT00000085775
alcohol sulfotransferase-like
chr9_+_95202632 6.72 ENSRNOT00000025652
UDP glucuronosyltransferase family 1 member A5
chr13_+_56598957 6.62 ENSRNOT00000016944
ENSRNOT00000080335
ENSRNOT00000089913
coagulation factor XIII B chain
chr4_+_65110746 6.59 ENSRNOT00000017675
aldo-keto reductase family 1, member D1
chr14_+_96499520 6.50 ENSRNOT00000074692

chr1_-_224389389 6.34 ENSRNOT00000077408
ENSRNOT00000050010
integral membrane transport protein UST4r
chr10_-_62273119 6.31 ENSRNOT00000004322
serpin family F member 2
chr1_-_263803150 6.20 ENSRNOT00000017840
cytochrome P450, family 2, subfamily c, polypeptide 23
chr4_-_69196430 6.19 ENSRNOT00000017673
Trypsin V-A
chr4_-_163762434 5.94 ENSRNOT00000081854
immunoreceptor Ly49si1
chr14_+_22375955 5.87 ENSRNOT00000063915
ENSRNOT00000034784
UDP-glucuronosyltransferase 2 family, member 37
chr3_+_18315320 5.70 ENSRNOT00000006954

chr1_+_147713892 5.65 ENSRNOT00000092985
ENSRNOT00000054742
ENSRNOT00000074103
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1
chr14_+_22251499 5.47 ENSRNOT00000087991
ENSRNOT00000002705
UDP glucuronosyltransferase 2 family, polypeptide A1
chr2_+_206342066 5.06 ENSRNOT00000026556
protein tyrosine phosphatase, non-receptor type 22
chr14_+_22806132 5.04 ENSRNOT00000002728
UDP glucuronosyltransferase 2 family, polypeptide B10
chr6_-_139041812 4.85 ENSRNOT00000074510

chr7_-_116106368 4.74 ENSRNOT00000035678
lymphocyte antigen 6 complex, locus K
chrX_-_110230610 4.72 ENSRNOT00000093401
serpin family A member 7
chr10_-_89454681 4.63 ENSRNOT00000028109
BRCA1, DNA repair associated
chr4_-_21920651 4.41 ENSRNOT00000066211
transmembrane protein 243
chr3_-_55451798 4.36 ENSRNOT00000008837
SPC25, NDC80 kinetochore complex component
chr4_-_164051812 4.34 ENSRNOT00000085719

chr3_+_20641664 4.14 ENSRNOT00000044699

chr20_+_46250363 4.10 ENSRNOT00000076522
ENSRNOT00000000334
CD164 molecule
chr4_-_81968832 3.98 ENSRNOT00000016608
src kinase associated phosphoprotein 2
chr4_-_157750088 3.98 ENSRNOT00000038023
CD27 molecule
chr3_-_37854561 3.97 ENSRNOT00000076095
nebulin
chr4_+_101645731 3.90 ENSRNOT00000087901

chr14_+_22417206 3.86 ENSRNOT00000052369
UDP-glucuronosyltransferase 2 family, member 37
chr13_+_83073544 3.84 ENSRNOT00000066119
ENSRNOT00000079796
ENSRNOT00000077070
dermatopontin
chr6_-_138852571 3.83 ENSRNOT00000081803

chr1_-_80615704 3.82 ENSRNOT00000041891
apolipoprotein E
chr15_+_57891680 3.81 ENSRNOT00000001383
tumor protein, translationally-controlled 1
chr3_-_19320915 3.78 ENSRNOT00000043673
similar to Ig variable region, light chain
chr20_-_3793985 3.77 ENSRNOT00000049540
ENSRNOT00000086293
RT1 class I, locus CE16
chr13_+_56546021 3.77 ENSRNOT00000016797
abnormal spindle microtubule assembly
chrX_+_28593405 3.76 ENSRNOT00000071708
thymosin beta 4, X-linked
chr1_-_80615525 3.76 ENSRNOT00000091574
apolipoprotein E
chr13_+_48745860 3.73 ENSRNOT00000010242
solute carrier family 45, member 3
chr6_+_139523337 3.70 ENSRNOT00000090711

chr6_-_138772894 3.63 ENSRNOT00000080779

chr15_+_24159647 3.63 ENSRNOT00000082675
galectin 3
chr15_+_31948035 3.59 ENSRNOT00000071627

chr20_-_2707108 3.58 ENSRNOT00000082052
ENSRNOT00000048535
RT1 class I, locus CE11-like
chr3_-_119135391 3.57 ENSRNOT00000045443
GA binding protein transcription factor, beta subunit 1
chr4_-_163402561 3.54 ENSRNOT00000091890
killer cell lectin like receptor K1
chr15_+_31719866 3.54 ENSRNOT00000072127

chr3_+_62481323 3.51 ENSRNOT00000078872
heterogeneous nuclear ribonucleoprotein A3
chr3_-_94808861 3.42 ENSRNOT00000038464
proline rich and Gla domain 4
chr15_-_23969011 3.38 ENSRNOT00000014821
GTP cyclohydrolase 1
chr12_-_2347543 3.35 ENSRNOT00000061727
CD209a molecule
chr10_+_111031414 3.29 ENSRNOT00000074372
patched domain containing 3
chr3_-_165700489 3.29 ENSRNOT00000017008
zinc finger protein 93
chr4_-_163403653 3.27 ENSRNOT00000088151
killer cell lectin like receptor K1
chr20_-_4935372 3.23 ENSRNOT00000050099
ENSRNOT00000047779
RT1 class I, locus CE3
RT1 class I, locus CE4
chr17_-_10004321 3.14 ENSRNOT00000042394
fibroblast growth factor receptor 4
chr13_-_95943761 3.13 ENSRNOT00000005961
adenylosuccinate synthase
chr13_-_47331187 3.13 ENSRNOT00000035577
ENSRNOT00000049915
zona pellucida 3 receptor
chr15_-_44627765 3.12 ENSRNOT00000058887
dedicator of cytokinesis 5
chr9_-_4876023 3.12 ENSRNOT00000065839
similar to Sulfotransferase K1 (rSULT1C2)
chr19_+_3325893 3.07 ENSRNOT00000048879
similar to Ig variable region, light chain
chr9_-_73958480 3.06 ENSRNOT00000017838
myosin, light chain 1
chr15_+_28319136 3.03 ENSRNOT00000048723
tubulin polymerization-promoting protein family member 2
chr12_-_20276121 3.01 ENSRNOT00000065873
similar to paired immunoglobin-like type 2 receptor beta
chr2_-_196415530 3.00 ENSRNOT00000064238
similar to hypothetical protein FLJ20519
chr2_+_76923591 2.99 ENSRNOT00000042759
signal-regulatory protein alpha-like
chr10_-_57837602 2.94 ENSRNOT00000075185
NLR family, pyrin domain containing 1B
chr16_+_18716019 2.92 ENSRNOT00000047870
surfactant protein A1
chr2_-_27364906 2.91 ENSRNOT00000078639
DNA polymerase kappa
chr19_-_914880 2.86 ENSRNOT00000017127
chemokine-like factor
chr2_+_223121410 2.85 ENSRNOT00000087559

chr20_+_5414448 2.85 ENSRNOT00000078972
ENSRNOT00000080900
RT1 class Ia, locus A1
chr15_-_34693034 2.85 ENSRNOT00000083314
mast cell protease 8
chr1_-_193328371 2.83 ENSRNOT00000019304
ENSRNOT00000031770
ENSRNOT00000019309
Rho GTPase activating protein 17
chr11_-_32469566 2.81 ENSRNOT00000002718
similar to RIKEN cDNA 4930563D23
chr15_-_29345785 2.80 ENSRNOT00000075484

chr6_+_91463308 2.80 ENSRNOT00000005595
leucine rich repeat protein 1
chr13_-_110678389 2.77 ENSRNOT00000082906

chr15_-_54906203 2.77 ENSRNOT00000020186
cysteinyl leukotriene receptor 2
chr16_-_24951612 2.76 ENSRNOT00000018987
transketolase-like 2
chr1_-_167698263 2.73 ENSRNOT00000093046
tripartite motif-containing 21
chr17_+_69634890 2.72 ENSRNOT00000029049
aldo-keto reductase family 1, member C13
chr1_-_162713610 2.69 ENSRNOT00000018091
aquaporin 11
chr2_-_187771857 2.68 ENSRNOT00000092517
ENSRNOT00000035383
polyamine-modulated factor 1
chr2_+_46140482 2.64 ENSRNOT00000072858
olfactory receptor 1262
chr17_-_43675934 2.61 ENSRNOT00000081345
histone cluster 1 H1 family member t
chr20_+_4852671 2.60 ENSRNOT00000001111
lymphotoxin alpha
chr9_-_23493081 2.51 ENSRNOT00000072144
Rh-associated glycoprotein
chr1_-_276012351 2.49 ENSRNOT00000045642

chr4_-_66624912 2.47 ENSRNOT00000064891
homeodomain interacting protein kinase 2
chr20_-_6257604 2.47 ENSRNOT00000092489
serine/threonine kinase 38
chr20_-_3796258 2.46 ENSRNOT00000048076
ENSRNOT00000044520
RT1 class I, locus CE16
chr20_-_4921348 2.44 ENSRNOT00000082497
ENSRNOT00000041151
RT1 class I, locus CE4
chr6_+_36941233 2.44 ENSRNOT00000007073
structural maintenance of chromosomes 6
chr20_-_31597830 2.41 ENSRNOT00000085877
collagen type XIII alpha 1 chain
chr1_+_105094411 2.41 ENSRNOT00000036258
HIV-1 Tat interactive protein 2
chr13_-_108178609 2.40 ENSRNOT00000004525
centromere protein F
chr15_-_29987717 2.39 ENSRNOT00000071501

chr15_+_31579478 2.38 ENSRNOT00000071642

chr2_+_52333396 2.34 ENSRNOT00000046174
similar to 4833420G17Rik protein
chr2_-_116002561 2.29 ENSRNOT00000012924
protein kinase C, iota
chr2_-_22798214 2.28 ENSRNOT00000016135
poly(A) RNA polymerase D4, non-canonical
chr16_-_74963044 2.28 ENSRNOT00000018362
coiled-coil domain containing 70
chrX_+_25737292 2.25 ENSRNOT00000004893
similar to RIKEN cDNA 4933400A11
chr5_+_135536413 2.24 ENSRNOT00000023132
peroxiredoxin 1
chr11_-_69355854 2.22 ENSRNOT00000002975
rhophilin associated tail protein 1
chr7_-_130350570 2.19 ENSRNOT00000055805
outer dense fiber of sperm tails 3B
chr3_+_72395218 2.18 ENSRNOT00000057616
proteoglycan 3, pro eosinophil major basic protein 2
chr15_+_35002406 2.17 ENSRNOT00000091167
mast cell protease 1-like 4
chr19_+_50045020 2.15 ENSRNOT00000090165
phospholipase C, gamma 2
chr3_+_120414291 2.15 ENSRNOT00000083627
ENSRNOT00000021740
acyl-CoA oxidase-like
chr4_-_174180729 2.14 ENSRNOT00000011376
phospholipase C, zeta 1
chr15_+_49010492 2.11 ENSRNOT00000024527
nuclear GTPase, germinal center associated
chr20_-_157665 2.10 ENSRNOT00000048858
ENSRNOT00000079494
RT1 class I, locus CE10
chr13_+_92249759 2.10 ENSRNOT00000089352
olfactory receptor 1596
chr19_+_880024 2.08 ENSRNOT00000061648
CKLF-like MARVEL transmembrane domain containing 2A
chr6_-_143131118 2.07 ENSRNOT00000074930

chr19_+_26022849 2.07 ENSRNOT00000014887
deoxyribonuclease 2, lysosomal
chrX_-_17708388 2.07 ENSRNOT00000048887
similar to mgclh
chrX_-_14783792 2.05 ENSRNOT00000087609
similar to ferritin, heavy polypeptide-like 17
chr16_-_70998575 2.05 ENSRNOT00000019935
potassium calcium-activated channel subfamily U member 1
chr1_+_266380973 2.03 ENSRNOT00000080509
WW domain binding protein 1-like
chr3_-_13978224 2.03 ENSRNOT00000025528
PHD finger protein 19
chr10_-_14247886 2.03 ENSRNOT00000020504
nucleotide binding protein 2
chr8_+_128027958 2.02 ENSRNOT00000045049
acetyl-Coenzyme A acyltransferase 1B
chr1_-_133559975 2.01 ENSRNOT00000046645
multiple C2 and transmembrane domain containing 2
chr3_+_1413671 2.01 ENSRNOT00000007675
interleukin 1 family member 10
chr20_-_31598118 1.99 ENSRNOT00000046537
collagen type XIII alpha 1 chain
chr1_-_247476827 1.98 ENSRNOT00000021298
insulin-like 6
chr7_-_9174330 1.97 ENSRNOT00000051063
olfactory receptor 1060
chr5_+_126668689 1.97 ENSRNOT00000036072
cytochrome b5 reductase-like
chr9_+_17216495 1.96 ENSRNOT00000026331
MAD2L1 binding protein
chr2_+_240396152 1.96 ENSRNOT00000034565
centromere protein E
chrX_-_158261717 1.96 ENSRNOT00000086804
similar to RIKEN cDNA 1700001F22
chr5_-_173484986 1.96 ENSRNOT00000064207
ENSRNOT00000055319
tubulin tyrosine ligase like 10
chr14_-_2032593 1.94 ENSRNOT00000000037
fibroblast growth factor receptor-like 1
chr8_+_39164916 1.92 ENSRNOT00000011309
acrosomal vesicle protein 1
chr10_-_104054805 1.86 ENSRNOT00000004853
5', 3'-nucleotidase, cytosolic
chr4_-_23135354 1.83 ENSRNOT00000011432
STEAP4 metalloreductase
chr2_+_206064179 1.80 ENSRNOT00000025953
synaptotagmin 6
chr3_+_19071980 1.79 ENSRNOT00000079487
immunoglobulin kappa variable 4-81
chr18_+_47294292 1.79 ENSRNOT00000020109
ferritin mitochondrial
chr5_-_118541928 1.78 ENSRNOT00000012947
integrin subunit beta 3 binding protein
chr17_-_42241066 1.76 ENSRNOT00000059570
tyrosyl-DNA phosphodiesterase 2
chr1_+_99648658 1.76 ENSRNOT00000039531
kallikrein related-peptidase 13
chr17_-_45727146 1.74 ENSRNOT00000083706
olfactory receptor 2W1-like
chr16_-_70006016 1.73 ENSRNOT00000092030
predicted gene 1141
chr1_+_83043490 1.72 ENSRNOT00000071029
carcinoembryonic antigen-related cell adhesion molecule 1-like
chr12_+_22727335 1.69 ENSRNOT00000077293
zinc finger, HIT-type containing 1
chr14_-_80355420 1.67 ENSRNOT00000049798
acyl-CoA oxidase 3, pristanoyl
chr17_-_31569904 1.67 ENSRNOT00000023962
receptor interacting serine/threonine kinase 1
chr18_+_86071662 1.67 ENSRNOT00000064901
rotatin
chr5_-_138629026 1.66 ENSRNOT00000049535
ribosomal protein S27a
chr3_-_2309179 1.63 ENSRNOT00000012375
NADPH oxidase activator 1
chr2_+_34312766 1.62 ENSRNOT00000060962
centromere protein K
chr14_-_1505085 1.59 ENSRNOT00000090361
uncharacterized LOC102554799
chr3_-_147263275 1.59 ENSRNOT00000029620
proteasome inhibitor subunit 1
chr17_+_18358712 1.57 ENSRNOT00000001979
nucleoporin 153
chrX_-_135342996 1.57 ENSRNOT00000084848
ENSRNOT00000008503
apoptosis inducing factor, mitochondria associated 1
chr9_+_4731914 1.54 ENSRNOT00000061893

chr11_+_57207656 1.54 ENSRNOT00000038207
ENSRNOT00000085754
phosphatidylinositol-specific phospholipase C, X domain containing 2
chr2_+_227080924 1.54 ENSRNOT00000029871
fatty acid binding protein 2
chr7_-_4293352 1.54 ENSRNOT00000047489
olfactory receptor 984
chr20_+_14577166 1.53 ENSRNOT00000085583
rhabdoid tumor deletion region gene 1
chr15_+_18920373 1.52 ENSRNOT00000036754
mCG11429-like
chr3_+_93351619 1.50 ENSRNOT00000011035
E74-like factor 5
chr8_+_129241109 1.49 ENSRNOT00000063787
ribosomal protein L14
chr20_-_30888735 1.49 ENSRNOT00000090004
ENSRNOT00000063875
ADAM metallopeptidase with thrombospondin type 1 motif, 14
chr10_-_95349789 1.47 ENSRNOT00000085210
bromodomain PHD finger transcription factor
chr4_-_117814658 1.47 ENSRNOT00000036247
dual specificity phosphatase 11
chr2_-_195486969 1.46 ENSRNOT00000075272
similar to TDPOZ2
chr6_-_141365198 1.46 ENSRNOT00000040523

chr1_+_80056755 1.46 ENSRNOT00000021221
small nuclear ribonucleoprotein D2 polypeptide
chr10_-_70339578 1.44 ENSRNOT00000076618
schlafen family member 13
chr17_-_19703681 1.42 ENSRNOT00000024021
myosin regulatory light chain interacting protein
chrX_+_137197396 1.42 ENSRNOT00000082227
similar to RIKEN cDNA 1700001F22
chr1_+_85143789 1.41 ENSRNOT00000071691
acid phosphatase 7, tartrate resistant
chr8_-_54961265 1.41 ENSRNOT00000012434
6-pyruvoyl-tetrahydropterin synthase
chr7_+_117055623 1.41 ENSRNOT00000012461
mitogen-activated protein kinase 15
chr8_+_116343096 1.40 ENSRNOT00000022092
interferon-related developmental regulator 2
chr1_+_260153645 1.40 ENSRNOT00000054717
zinc finger protein 518A
chr8_+_129240528 1.39 ENSRNOT00000083427
ribosomal protein L14
chrX_+_43293551 1.39 ENSRNOT00000084562
hypothetical protein LOC680190
chr14_-_84662143 1.39 ENSRNOT00000057529
ENSRNOT00000080078
HORMA domain containing 2
chr9_+_16508799 1.38 ENSRNOT00000021803
ribosomal protein L7-like 1

Network of associatons between targets according to the STRING database.

First level regulatory network of Sp100

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
5.5 16.5 GO:0061744 motor behavior(GO:0061744)
2.6 7.8 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
2.5 7.6 GO:1903000 regulation of lipid transport across blood brain barrier(GO:1903000) positive regulation of lipid transport across blood brain barrier(GO:1903002)
2.3 6.8 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223) negative regulation of natural killer cell chemotaxis(GO:2000502)
1.7 6.8 GO:0001834 trophectodermal cell proliferation(GO:0001834)
1.7 5.1 GO:0070425 positive regulation of toll-like receptor 9 signaling pathway(GO:0034165) negative regulation of nucleotide-binding oligomerization domain containing signaling pathway(GO:0070425) negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway(GO:0070433) granzyme B production(GO:0071613) regulation of granzyme B production(GO:0071661) positive regulation of granzyme B production(GO:0071663)
1.5 4.6 GO:2000620 positive regulation of histone H4-K16 acetylation(GO:2000620)
1.3 8.1 GO:0002457 T cell antigen processing and presentation(GO:0002457)
1.3 3.8 GO:2000383 regulation of ectoderm development(GO:2000383) negative regulation of ectoderm development(GO:2000384)
1.3 6.3 GO:0003072 regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072)
1.2 3.7 GO:0015772 disaccharide transport(GO:0015766) sucrose transport(GO:0015770) oligosaccharide transport(GO:0015772)
1.2 3.6 GO:1903769 negative regulation of cell proliferation in bone marrow(GO:1903769)
1.1 5.6 GO:0016098 monoterpenoid metabolic process(GO:0016098)
1.1 3.4 GO:0014916 regulation of lung blood pressure(GO:0014916)
1.0 3.1 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
1.0 3.1 GO:1904694 negative regulation of vascular smooth muscle contraction(GO:1904694)
1.0 2.9 GO:0002462 tolerance induction to nonself antigen(GO:0002462)
0.9 12.2 GO:0052695 cellular glucuronidation(GO:0052695)
0.9 2.6 GO:0002876 positive regulation of chronic inflammatory response to antigenic stimulus(GO:0002876)
0.8 3.1 GO:2000830 vacuolar phosphate transport(GO:0007037) positive regulation of parathyroid hormone secretion(GO:2000830)
0.7 2.2 GO:0045575 basophil activation(GO:0045575)
0.7 7.6 GO:0015747 urate transport(GO:0015747)
0.7 16.2 GO:0019373 epoxygenase P450 pathway(GO:0019373)
0.7 2.0 GO:0018094 protein polyglycylation(GO:0018094)
0.6 3.8 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
0.6 3.8 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.6 6.6 GO:0016127 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.6 1.7 GO:0033540 fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540)
0.6 1.7 GO:0060545 regulation of nucleoside transport(GO:0032242) positive regulation of necroptotic process(GO:0060545)
0.5 2.7 GO:0015793 glycerol transport(GO:0015793)
0.5 2.1 GO:2000224 regulation of testosterone biosynthetic process(GO:2000224)
0.5 1.5 GO:0001712 ectodermal cell fate commitment(GO:0001712)
0.5 1.9 GO:0009223 pyrimidine deoxyribonucleotide catabolic process(GO:0009223)
0.5 2.8 GO:0061737 leukotriene signaling pathway(GO:0061737)
0.5 0.9 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.4 1.8 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 4.7 GO:0070327 thyroid hormone transport(GO:0070327)
0.4 18.6 GO:0002474 antigen processing and presentation of peptide antigen via MHC class I(GO:0002474)
0.4 2.9 GO:0006297 nucleotide-excision repair, DNA gap filling(GO:0006297)
0.4 1.2 GO:0098507 polynucleotide 5' dephosphorylation(GO:0098507)
0.4 1.2 GO:1902953 positive regulation of ER to Golgi vesicle-mediated transport(GO:1902953)
0.4 1.8 GO:0060478 acrosomal vesicle exocytosis(GO:0060478)
0.4 1.1 GO:0006117 acetaldehyde metabolic process(GO:0006117)
0.4 1.4 GO:0032803 low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803)
0.3 1.0 GO:2001137 positive regulation of endocytic recycling(GO:2001137)
0.3 2.7 GO:0090086 negative regulation of protein deubiquitination(GO:0090086)
0.3 2.3 GO:0048194 Golgi vesicle budding(GO:0048194)
0.3 1.0 GO:0021997 neural plate axis specification(GO:0021997)
0.3 2.0 GO:0051987 positive regulation of attachment of spindle microtubules to kinetochore(GO:0051987)
0.3 2.9 GO:0008228 opsonization(GO:0008228)
0.3 4.2 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
0.3 10.9 GO:0007339 binding of sperm to zona pellucida(GO:0007339)
0.3 1.6 GO:1904045 cellular response to aldosterone(GO:1904045)
0.3 2.5 GO:0060235 voluntary musculoskeletal movement(GO:0050882) lens induction in camera-type eye(GO:0060235)
0.3 3.5 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.3 1.1 GO:0071718 sodium-independent icosanoid transport(GO:0071718)
0.3 0.8 GO:1905076 regulation of interleukin-17 secretion(GO:1905076) negative regulation of interleukin-17 secretion(GO:1905077)
0.3 2.0 GO:0061087 positive regulation of histone H3-K27 methylation(GO:0061087)
0.2 1.4 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.2 1.8 GO:0098706 ferric iron import(GO:0033216) ferric iron import into cell(GO:0097461) ferric iron import across plasma membrane(GO:0098706)
0.2 0.9 GO:0035937 estrogen secretion(GO:0035937) estradiol secretion(GO:0035938) regulation of estrogen secretion(GO:2000861) regulation of estradiol secretion(GO:2000864)
0.2 0.7 GO:0035622 intrahepatic bile duct development(GO:0035622)
0.2 4.0 GO:0045579 positive regulation of B cell differentiation(GO:0045579)
0.2 2.1 GO:0038095 activation of store-operated calcium channel activity(GO:0032237) Fc-epsilon receptor signaling pathway(GO:0038095) positive regulation of store-operated calcium channel activity(GO:1901341)
0.2 2.5 GO:0060586 multicellular organismal iron ion homeostasis(GO:0060586)
0.2 2.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
0.2 0.9 GO:0038145 macrophage colony-stimulating factor signaling pathway(GO:0038145)
0.2 1.7 GO:0070317 negative regulation of G0 to G1 transition(GO:0070317)
0.2 0.7 GO:1904354 negative regulation of telomere capping(GO:1904354)
0.2 0.5 GO:0000432 regulation of transcription from RNA polymerase II promoter by glucose(GO:0000430) positive regulation of transcription from RNA polymerase II promoter by glucose(GO:0000432) late viral transcription(GO:0019086)
0.2 1.9 GO:0060539 diaphragm development(GO:0060539)
0.2 2.4 GO:0046831 regulation of RNA export from nucleus(GO:0046831)
0.2 1.9 GO:0007096 regulation of exit from mitosis(GO:0007096)
0.2 0.6 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
0.2 1.4 GO:0045144 meiotic sister chromatid segregation(GO:0045144) meiotic sister chromatid cohesion(GO:0051177)
0.1 0.7 GO:0090166 Golgi disassembly(GO:0090166)
0.1 0.4 GO:0061144 alveolar secondary septum development(GO:0061144)
0.1 0.4 GO:0035425 autocrine signaling(GO:0035425)
0.1 0.4 GO:2001268 negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway(GO:2001268)
0.1 1.0 GO:0006621 protein retention in ER lumen(GO:0006621)
0.1 2.2 GO:0019430 removal of superoxide radicals(GO:0019430)
0.1 2.9 GO:0050718 positive regulation of interleukin-1 secretion(GO:0050716) positive regulation of interleukin-1 beta secretion(GO:0050718)
0.1 2.1 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 4.4 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 2.3 GO:0071044 histone mRNA catabolic process(GO:0071044)
0.1 0.4 GO:0018199 peptidyl-glutamine modification(GO:0018199)
0.1 1.2 GO:0043305 negative regulation of mast cell activation involved in immune response(GO:0033007) negative regulation of mast cell degranulation(GO:0043305)
0.1 0.5 GO:0048478 replication fork protection(GO:0048478)
0.1 0.5 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041)
0.1 1.3 GO:1902570 protein localization to nucleolus(GO:1902570)
0.1 0.7 GO:0031053 primary miRNA processing(GO:0031053)
0.1 18.0 GO:0007586 digestion(GO:0007586)
0.1 0.7 GO:1901838 positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.1 5.3 GO:0030199 collagen fibril organization(GO:0030199)
0.1 1.6 GO:0010310 regulation of hydrogen peroxide metabolic process(GO:0010310)
0.1 0.5 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.1 0.9 GO:0061635 regulation of protein complex stability(GO:0061635)
0.1 0.9 GO:0051151 negative regulation of smooth muscle cell differentiation(GO:0051151)
0.1 9.2 GO:0042100 B cell proliferation(GO:0042100)
0.1 0.9 GO:0035745 T-helper 2 cell cytokine production(GO:0035745)
0.1 0.4 GO:0021526 medial motor column neuron differentiation(GO:0021526)
0.1 0.3 GO:2000313 fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:0060825) regulation of fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation(GO:2000313)
0.1 2.2 GO:0048240 sperm capacitation(GO:0048240)
0.1 2.0 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.1 0.5 GO:0019348 dolichol metabolic process(GO:0019348)
0.1 0.4 GO:0006564 L-serine biosynthetic process(GO:0006564) threonine metabolic process(GO:0006566)
0.1 0.7 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.1 1.0 GO:0048664 neuron fate determination(GO:0048664)
0.1 0.8 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
0.1 5.7 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 2.9 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.1 0.4 GO:0045218 zonula adherens maintenance(GO:0045218)
0.1 0.8 GO:0043922 negative regulation by host of viral transcription(GO:0043922)
0.1 4.1 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.1 1.4 GO:1904355 positive regulation of telomere capping(GO:1904355)
0.1 0.7 GO:0006108 malate metabolic process(GO:0006108)
0.1 0.3 GO:0000733 DNA strand renaturation(GO:0000733)
0.1 1.6 GO:0034723 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.1 0.6 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.6 GO:0070197 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.6 GO:0007406 negative regulation of neuroblast proliferation(GO:0007406)
0.1 0.6 GO:0002227 innate immune response in mucosa(GO:0002227)
0.0 1.3 GO:0043153 entrainment of circadian clock by photoperiod(GO:0043153)
0.0 6.3 GO:0006413 translational initiation(GO:0006413)
0.0 0.1 GO:0033030 negative regulation of neutrophil apoptotic process(GO:0033030)
0.0 1.2 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 0.2 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.0 1.5 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 1.4 GO:0042572 retinol metabolic process(GO:0042572)
0.0 0.9 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
0.0 0.2 GO:0035511 oxidative DNA demethylation(GO:0035511)
0.0 0.9 GO:0045648 positive regulation of erythrocyte differentiation(GO:0045648)
0.0 1.1 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.0 0.5 GO:1904262 negative regulation of TORC1 signaling(GO:1904262)
0.0 2.4 GO:0010389 regulation of G2/M transition of mitotic cell cycle(GO:0010389)
0.0 0.2 GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000480)
0.0 2.5 GO:0043407 negative regulation of MAP kinase activity(GO:0043407)
0.0 2.1 GO:0006635 fatty acid beta-oxidation(GO:0006635)
0.0 1.6 GO:1901799 negative regulation of proteasomal protein catabolic process(GO:1901799)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 3.1 GO:0007052 mitotic spindle organization(GO:0007052)
0.0 3.6 GO:0042113 B cell activation(GO:0042113)
0.0 2.0 GO:1990090 cellular response to nerve growth factor stimulus(GO:1990090)
0.0 2.1 GO:0051028 mRNA transport(GO:0051028)
0.0 0.6 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.0 7.1 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 1.3 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 0.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.2 GO:0090214 spongiotrophoblast layer developmental growth(GO:0090214)
0.0 4.0 GO:0007596 blood coagulation(GO:0007596)
0.0 0.3 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 1.1 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.0 1.1 GO:0071806 protein transmembrane transport(GO:0071806)
0.0 1.2 GO:0006414 translational elongation(GO:0006414)
0.0 1.4 GO:0001895 retina homeostasis(GO:0001895)
0.0 1.1 GO:0045727 positive regulation of translation(GO:0045727)
0.0 0.8 GO:0007019 microtubule depolymerization(GO:0007019)
0.0 0.8 GO:2000134 negative regulation of G1/S transition of mitotic cell cycle(GO:2000134)
0.0 1.1 GO:0010923 negative regulation of phosphatase activity(GO:0010923)
0.0 3.3 GO:0006869 lipid transport(GO:0006869)
0.0 3.0 GO:0016485 protein processing(GO:0016485)
0.0 1.6 GO:0007286 spermatid development(GO:0007286)
0.0 0.6 GO:0002088 lens development in camera-type eye(GO:0002088)
0.0 0.3 GO:0006270 DNA replication initiation(GO:0006270)
0.0 1.5 GO:0006302 double-strand break repair(GO:0006302)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 16.5 GO:0071438 invadopodium membrane(GO:0071438)
1.5 7.6 GO:0034365 discoidal high-density lipoprotein particle(GO:0034365)
1.4 6.8 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)
1.2 4.6 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
1.0 8.1 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
1.0 3.8 GO:0045298 tubulin complex(GO:0045298)
0.9 14.2 GO:0042612 MHC class I protein complex(GO:0042612)
0.9 4.4 GO:0031262 Ndc80 complex(GO:0031262)
0.9 4.3 GO:0035061 interchromatin granule(GO:0035061)
0.8 6.3 GO:0005577 fibrinogen complex(GO:0005577)
0.8 3.1 GO:0034774 secretory granule lumen(GO:0034774)
0.7 2.7 GO:0000444 MIS12/MIND type complex(GO:0000444)
0.5 3.8 GO:0036449 microtubule minus-end(GO:0036449)
0.4 2.9 GO:0072559 NLRP3 inflammasome complex(GO:0072559)
0.4 1.2 GO:0005853 eukaryotic translation elongation factor 1 complex(GO:0005853)
0.4 2.2 GO:0097598 sperm cytoplasmic droplet(GO:0097598)
0.4 4.4 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
0.3 1.0 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.3 0.9 GO:1990682 CSF1-CSF1R complex(GO:1990682)
0.3 1.7 GO:0097342 ripoptosome(GO:0097342)
0.3 1.6 GO:0005642 annulate lamellae(GO:0005642)
0.2 2.0 GO:0016589 NURF complex(GO:0016589)
0.2 1.5 GO:0034715 pICln-Sm protein complex(GO:0034715)
0.2 1.2 GO:0034388 Pwp2p-containing subcomplex of 90S preribosome(GO:0034388)
0.2 4.2 GO:0097225 sperm midpiece(GO:0097225)
0.2 1.6 GO:0043020 NADPH oxidase complex(GO:0043020)
0.2 0.5 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
0.2 3.5 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.2 2.0 GO:0031616 spindle pole centrosome(GO:0031616)
0.1 1.7 GO:0000812 Swr1 complex(GO:0000812)
0.1 0.4 GO:0033185 dolichol-phosphate-mannose synthase complex(GO:0033185)
0.1 1.2 GO:0045179 apical cortex(GO:0045179)
0.1 1.1 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.1 2.2 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.1 2.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.1 0.7 GO:0001651 dense fibrillar component(GO:0001651)
0.1 7.3 GO:0005581 collagen trimer(GO:0005581)
0.1 1.8 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 6.3 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
0.1 3.6 GO:0001772 immunological synapse(GO:0001772)
0.1 3.8 GO:0045171 intercellular bridge(GO:0045171)
0.1 0.8 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 2.1 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.1 0.5 GO:0070531 BRCA1-A complex(GO:0070531)
0.1 23.6 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 3.2 GO:0016235 aggresome(GO:0016235)
0.1 0.5 GO:0031298 replication fork protection complex(GO:0031298)
0.1 0.6 GO:0036057 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
0.1 0.6 GO:0070187 telosome(GO:0070187)
0.1 1.4 GO:0005640 nuclear outer membrane(GO:0005640)
0.1 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.1 0.6 GO:0072546 ER membrane protein complex(GO:0072546)
0.1 0.5 GO:0061700 GATOR2 complex(GO:0061700)
0.0 4.5 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.2 GO:0035145 exon-exon junction complex(GO:0035145)
0.0 3.3 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 1.3 GO:0034451 centriolar satellite(GO:0034451)
0.0 0.4 GO:0005915 zonula adherens(GO:0005915)
0.0 3.7 GO:0000794 condensed nuclear chromosome(GO:0000794)
0.0 0.7 GO:1902555 endoribonuclease complex(GO:1902555)
0.0 1.6 GO:0030173 integral component of Golgi membrane(GO:0030173)
0.0 1.2 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.0 0.4 GO:0002199 zona pellucida receptor complex(GO:0002199)
0.0 23.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.3 GO:0042555 MCM complex(GO:0042555)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 24.9 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0005801 cis-Golgi network(GO:0005801)
0.0 3.8 GO:0010008 endosome membrane(GO:0010008)
0.0 1.4 GO:0000784 nuclear chromosome, telomeric region(GO:0000784)
0.0 0.6 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.7 GO:0015030 Cajal body(GO:0015030)
0.0 0.8 GO:0005871 kinesin complex(GO:0005871)
0.0 0.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.0 1.4 GO:0005923 bicellular tight junction(GO:0005923)
0.0 1.5 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.7 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.5 7.6 GO:0046911 metal chelating activity(GO:0046911)
2.2 6.6 GO:0047787 delta4-3-oxosteroid 5beta-reductase activity(GO:0047787)
1.6 16.5 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
1.2 3.7 GO:0015157 sucrose:proton symporter activity(GO:0008506) sucrose transmembrane transporter activity(GO:0008515) disaccharide transmembrane transporter activity(GO:0015154) oligosaccharide transmembrane transporter activity(GO:0015157)
1.2 38.5 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.9 7.8 GO:0019198 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.8 9.3 GO:0004875 complement receptor activity(GO:0004875)
0.8 3.8 GO:0003997 acyl-CoA oxidase activity(GO:0003997)
0.7 21.9 GO:0008392 arachidonic acid epoxygenase activity(GO:0008392)
0.7 3.6 GO:0050785 advanced glycation end-product receptor activity(GO:0050785)
0.7 3.5 GO:0051032 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
0.7 9.0 GO:0032453 histone demethylase activity (H3-K4 specific)(GO:0032453)
0.7 5.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.7 2.0 GO:0070735 protein-glycine ligase activity(GO:0070735)
0.6 6.3 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.6 4.7 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.6 2.2 GO:0008379 thioredoxin peroxidase activity(GO:0008379)
0.6 2.8 GO:0004974 leukotriene receptor activity(GO:0004974)
0.5 2.0 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.5 3.4 GO:0019238 cyclohydrolase activity(GO:0019238)
0.4 9.8 GO:0042288 MHC class I protein binding(GO:0042288)
0.4 1.2 GO:0004651 polynucleotide 5'-phosphatase activity(GO:0004651)
0.4 2.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
0.3 2.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.3 2.5 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.3 6.8 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.3 1.8 GO:0008823 cupric reductase activity(GO:0008823) ferric-chelate reductase (NADPH) activity(GO:0052851)
0.3 2.0 GO:0003988 acetyl-CoA C-acyltransferase activity(GO:0003988)
0.3 9.4 GO:0042605 peptide antigen binding(GO:0042605)
0.3 2.5 GO:0046790 virion binding(GO:0046790)
0.3 1.5 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 1.0 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.2 2.9 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.2 2.0 GO:0043515 kinetochore binding(GO:0043515)
0.2 2.8 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.2 4.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 3.9 GO:0005537 mannose binding(GO:0005537)
0.2 4.0 GO:0005035 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.2 1.9 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
0.2 0.6 GO:0005502 11-cis retinal binding(GO:0005502)
0.2 0.9 GO:0005315 inorganic phosphate transmembrane transporter activity(GO:0005315)
0.2 0.7 GO:0032296 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
0.2 0.7 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
0.2 0.7 GO:0042134 rRNA primary transcript binding(GO:0042134)
0.2 2.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 1.6 GO:0043495 protein anchor(GO:0043495)
0.2 1.6 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.2 1.6 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.2 1.5 GO:1990446 U1 snRNP binding(GO:1990446)
0.2 1.3 GO:0008559 xenobiotic-transporting ATPase activity(GO:0008559)
0.2 1.1 GO:0071532 ankyrin repeat binding(GO:0071532)
0.2 4.0 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 3.8 GO:0003785 actin monomer binding(GO:0003785)
0.1 30.5 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 2.1 GO:0016889 endodeoxyribonuclease activity, producing 3'-phosphomonoesters(GO:0016889)
0.1 1.1 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.1 0.8 GO:0061578 Lys63-specific deubiquitinase activity(GO:0061578)
0.1 1.1 GO:0015450 P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450)
0.1 13.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 0.6 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
0.1 0.3 GO:0009378 four-way junction helicase activity(GO:0009378)
0.1 7.2 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 2.9 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 0.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
0.1 1.0 GO:0070513 death domain binding(GO:0070513)
0.1 2.4 GO:0070840 dynein complex binding(GO:0070840)
0.1 1.6 GO:0070628 proteasome binding(GO:0070628)
0.1 0.7 GO:0008121 ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681)
0.1 2.4 GO:0031435 mitogen-activated protein kinase kinase kinase binding(GO:0031435)
0.1 1.4 GO:0003993 acid phosphatase activity(GO:0003993)
0.1 2.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.1 0.5 GO:0070728 leucine binding(GO:0070728)
0.1 5.1 GO:1990782 protein tyrosine kinase binding(GO:1990782)
0.1 0.6 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 1.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 4.3 GO:0003684 damaged DNA binding(GO:0003684)
0.1 2.6 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 2.4 GO:0008009 chemokine activity(GO:0008009)
0.1 1.4 GO:0004707 MAP kinase activity(GO:0004707)
0.1 3.1 GO:0016879 ligase activity, forming carbon-nitrogen bonds(GO:0016879)
0.1 1.2 GO:0003746 translation elongation factor activity(GO:0003746)
0.1 1.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
0.1 0.3 GO:0005047 signal recognition particle binding(GO:0005047)
0.1 3.4 GO:0008146 sulfotransferase activity(GO:0008146)
0.0 1.4 GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors(GO:0016627)
0.0 0.7 GO:0070182 DNA polymerase binding(GO:0070182)
0.0 0.2 GO:0035514 DNA demethylase activity(GO:0035514)
0.0 1.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.6 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
0.0 0.4 GO:0070097 delta-catenin binding(GO:0070097)
0.0 0.6 GO:0004697 protein kinase C activity(GO:0004697)
0.0 1.8 GO:0030145 manganese ion binding(GO:0030145)
0.0 2.0 GO:0008094 DNA-dependent ATPase activity(GO:0008094)
0.0 1.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.0 8.7 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.7 GO:0031491 nucleosome binding(GO:0031491)
0.0 0.3 GO:0003678 DNA helicase activity(GO:0003678)
0.0 1.1 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 5.3 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.9 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 4.5 GO:0008017 microtubule binding(GO:0008017)
0.0 0.6 GO:0019840 isoprenoid binding(GO:0019840)
0.0 1.0 GO:0004722 protein serine/threonine phosphatase activity(GO:0004722)
0.0 0.7 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 2.4 GO:0005179 hormone activity(GO:0005179)
0.0 1.3 GO:0004866 endopeptidase inhibitor activity(GO:0004866)
0.0 1.7 GO:0008201 heparin binding(GO:0008201)
0.0 0.6 GO:0035064 methylated histone binding(GO:0035064)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 19.3 SIG BCR SIGNALING PATHWAY Members of the BCR signaling pathway
0.2 5.1 PID IGF1 PATHWAY IGF1 pathway
0.1 1.2 ST IL 13 PATHWAY Interleukin 13 (IL-13) Pathway
0.1 2.4 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 4.6 PID AURORA A PATHWAY Aurora A signaling
0.1 2.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 5.8 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.8 PID CD40 PATHWAY CD40/CD40L signaling
0.1 2.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.1 2.0 PID TRAIL PATHWAY TRAIL signaling pathway
0.1 4.4 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.1 3.4 PID FOXM1 PATHWAY FOXM1 transcription factor network
0.1 2.5 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.1 1.6 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.1 18.4 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 1.0 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.6 PID FGF PATHWAY FGF signaling pathway
0.1 2.2 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 1.7 PID RAS PATHWAY Regulation of Ras family activation
0.0 1.5 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.0 0.9 PID CERAMIDE PATHWAY Ceramide signaling pathway
0.0 1.0 SIG CHEMOTAXIS Genes related to chemotaxis
0.0 1.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.5 PID P53 REGULATION PATHWAY p53 pathway
0.0 1.4 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 0.5 PID ATM PATHWAY ATM pathway
0.0 0.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.4 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 2.7 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.2 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 16.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.9 17.2 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.7 7.8 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.5 6.6 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS VIA 24 HYDROXYCHOLESTEROL Genes involved in Synthesis of bile acids and bile salts via 24-hydroxycholesterol
0.4 7.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.4 6.6 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.4 7.4 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.4 4.8 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.4 5.9 REACTOME P75NTR SIGNALS VIA NFKB Genes involved in p75NTR signals via NF-kB
0.3 3.1 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.3 3.6 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
0.2 4.0 REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS Genes involved in Signal regulatory protein (SIRP) family interactions
0.2 3.1 REACTOME FGFR4 LIGAND BINDING AND ACTIVATION Genes involved in FGFR4 ligand binding and activation
0.2 1.7 REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 Genes involved in IKK complex recruitment mediated by RIP1
0.2 2.8 REACTOME EICOSANOID LIGAND BINDING RECEPTORS Genes involved in Eicosanoid ligand-binding receptors
0.2 1.2 REACTOME INTEGRATION OF ENERGY METABOLISM Genes involved in Integration of energy metabolism
0.2 4.3 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.2 7.0 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.2 1.8 REACTOME NRIF SIGNALS CELL DEATH FROM THE NUCLEUS Genes involved in NRIF signals cell death from the nucleus
0.2 6.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 0.4 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.1 1.3 REACTOME ABACAVIR TRANSPORT AND METABOLISM Genes involved in Abacavir transport and metabolism
0.1 1.1 REACTOME TRANSPORT OF ORGANIC ANIONS Genes involved in Transport of organic anions
0.1 2.8 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 10.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 8.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 4.7 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 0.8 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.1 0.6 REACTOME OPSINS Genes involved in Opsins
0.1 2.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 2.1 REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers
0.1 1.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.1 1.3 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 6.4 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 1.1 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.0 1.5 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 0.9 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.0 0.7 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.0 0.7 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.0 0.5 REACTOME FORMATION OF TRANSCRIPTION COUPLED NER TC NER REPAIR COMPLEX Genes involved in Formation of transcription-coupled NER (TC-NER) repair complex
0.0 1.3 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
0.0 0.6 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.0 1.0 REACTOME G1 PHASE Genes involved in G1 Phase
0.0 0.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 2.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.8 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 0.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 2.9 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.6 REACTOME MRNA SPLICING Genes involved in mRNA Splicing