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GSE53960: rat RNA-Seq transcriptomic Bodymap
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Results for Sp1
Z-value: 2.01
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Transcription factors associated with Sp1
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| Sp1 | rn6_v1_chr7_+_144014173_144014173 | -0.02 | 7.9e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_34186091 Show fit | 72.12 |
ENSRNOT00000016129
|
small glutamine rich tetratricopeptide repeat containing beta |
|
| chr1_-_216663720 Show fit | 71.89 |
ENSRNOT00000078944
ENSRNOT00000077409 |
cyclin-dependent kinase inhibitor 1C |
|
| chr6_+_132246602 Show fit | 66.42 |
ENSRNOT00000009896
|
cytochrome P450, family 46, subfamily a, polypeptide 1 |
|
| chr1_+_166564664 Show fit | 63.48 |
ENSRNOT00000090959
|
phosphodiesterase 2A |
|
| chr5_+_156876706 Show fit | 59.36 |
ENSRNOT00000021864
|
calcium/calmodulin-dependent protein kinase II inhibitor 1 |
|
| chr7_+_123043503 Show fit | 59.34 |
ENSRNOT00000026258
ENSRNOT00000086355 |
TEF, PAR bZIP transcription factor |
|
| chr3_+_152552822 Show fit | 57.35 |
ENSRNOT00000089719
|
erythrocyte membrane protein band 4.1-like 1 |
|
| chr1_+_80195532 Show fit | 57.31 |
ENSRNOT00000022528
|
reticulon 2 |
|
| chr5_-_164971903 Show fit | 57.13 |
ENSRNOT00000067059
|
F-box protein 44 |
|
| chr16_-_20439206 Show fit | 56.45 |
ENSRNOT00000026391
|
RAB3A, member RAS oncogene family |
Network of associatons between targets according to the STRING database.
First level regulatory network of Sp1
Gene Ontology Analysis
Gene overrepresentation in biological process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 205.2 | GO:0048168 | regulation of neuronal synaptic plasticity(GO:0048168) |
| 5.0 | 181.1 | GO:0046928 | regulation of neurotransmitter secretion(GO:0046928) |
| 4.5 | 133.6 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 4.9 | 133.1 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 13.0 | 130.4 | GO:0036376 | sodium ion export from cell(GO:0036376) |
| 9.8 | 126.9 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 5.3 | 126.4 | GO:2000300 | regulation of synaptic vesicle exocytosis(GO:2000300) |
| 13.0 | 117.3 | GO:2001135 | regulation of endocytic recycling(GO:2001135) |
| 8.3 | 107.6 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 13.8 | 96.9 | GO:0016185 | synaptic vesicle budding from presynaptic endocytic zone membrane(GO:0016185) |
Gene overrepresentation in cellular component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1756.7 | GO:0016021 | integral component of membrane(GO:0016021) |
| 0.8 | 760.4 | GO:0005739 | mitochondrion(GO:0005739) |
| 3.8 | 740.7 | GO:0043209 | myelin sheath(GO:0043209) |
| 1.2 | 639.9 | GO:0005789 | endoplasmic reticulum membrane(GO:0005789) |
| 3.4 | 622.3 | GO:0097060 | synaptic membrane(GO:0097060) |
| 0.9 | 570.4 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 4.4 | 444.6 | GO:0043195 | terminal bouton(GO:0043195) |
| 1.5 | 441.4 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 6.9 | 315.2 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.9 | 251.9 | GO:0043025 | neuronal cell body(GO:0043025) |
Gene overrepresentation in molecular function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 424.7 | GO:0005509 | calcium ion binding(GO:0005509) |
| 2.7 | 271.1 | GO:0044325 | ion channel binding(GO:0044325) |
| 4.5 | 268.6 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 2.7 | 246.5 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 1.0 | 232.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 2.5 | 205.2 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 5.4 | 177.5 | GO:0043236 | laminin binding(GO:0043236) |
| 4.5 | 162.0 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 4.8 | 157.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 6.0 | 151.1 | GO:0031489 | myosin V binding(GO:0031489) |
Gene overrepresentation in curated gene sets: canonical pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.6 | 360.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 2.0 | 327.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 2.0 | 293.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 5.2 | 222.2 | PID NCADHERIN PATHWAY | N-cadherin signaling events |
| 6.5 | 194.2 | PID S1P S1P2 PATHWAY | S1P2 pathway |
| 4.8 | 161.8 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 3.0 | 153.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 3.0 | 145.9 | PID BMP PATHWAY | BMP receptor signaling |
| 13.2 | 145.0 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
| 2.8 | 135.5 | PID INTEGRIN1 PATHWAY | Beta1 integrin cell surface interactions |
Gene overrepresentation in curated gene sets: REACTOME pathways category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.5 | 248.4 | REACTOME GLUCONEOGENESIS | Genes involved in Gluconeogenesis |
| 5.7 | 245.2 | REACTOME REGULATION OF INSULIN SECRETION BY GLUCAGON LIKE PEPTIDE1 | Genes involved in Regulation of Insulin Secretion by Glucagon-like Peptide-1 |
| 13.9 | 208.2 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 7.6 | 205.4 | REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS | Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis |
| 3.8 | 186.1 | REACTOME L1CAM INTERACTIONS | Genes involved in L1CAM interactions |
| 4.5 | 174.3 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 3.7 | 156.7 | REACTOME REGULATION OF INSULIN SECRETION | Genes involved in Regulation of Insulin Secretion |
| 9.0 | 153.2 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |
| 12.5 | 149.6 | REACTOME VEGF LIGAND RECEPTOR INTERACTIONS | Genes involved in VEGF ligand-receptor interactions |
| 2.3 | 146.6 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |