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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox8

Z-value: 0.35

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Transcription factors associated with Sox8

Gene Symbol Gene ID Gene Info
Sox8
ENSRNOG00000018841 SRY box 8

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox8rn6_v1_chr10_-_14937336_149373360.574.9e-29Click!

Activity profile of Sox8 motif

Sorted Z-values of Sox8 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr8_+_39305128 12.03 ENSRNOT00000008285
Fez1
fasciculation and elongation protein zeta 1
chr9_-_75528644 11.92 ENSRNOT00000019283
Erbb4
erb-b2 receptor tyrosine kinase 4
chr16_-_18937562 9.35 ENSRNOT00000080387
Nwd1
NACHT and WD repeat domain containing 1
chr1_-_198233588 9.03 ENSRNOT00000088473
Aldoa
aldolase, fructose-bisphosphate A
chr17_+_53231343 7.93 ENSRNOT00000021703
Hecw1
HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
chr18_+_15490717 7.85 ENSRNOT00000091557
B4galt6
beta-1,4-galactosyltransferase 6
chr17_-_52477575 7.84 ENSRNOT00000081290
Gli3
GLI family zinc finger 3
chr1_-_198233215 7.81 ENSRNOT00000087928
Aldoa
aldolase, fructose-bisphosphate A
chr1_+_224882439 7.57 ENSRNOT00000024785
Chrm1
cholinergic receptor, muscarinic 1
chr4_-_150485781 6.62 ENSRNOT00000008763
Zfp248
zinc finger protein 248
chr1_+_99486253 4.29 ENSRNOT00000074820
LOC102546648
uncharacterized LOC102546648
chr18_+_17403407 4.09 ENSRNOT00000045150
RGD1562608
similar to KIAA1328 protein
chr15_+_41937880 3.95 ENSRNOT00000032514
Kcnrg
potassium channel regulator
chr5_-_819326 3.89 ENSRNOT00000023899
Pi15
peptidase inhibitor 15
chr20_+_1787174 3.81 ENSRNOT00000072824
ENSRNOT00000041883
Olr1738
olfactory receptor 1738
chr6_-_132972511 3.61 ENSRNOT00000082216
Begain
brain-enriched guanylate kinase-associated
chr1_+_99505677 2.88 ENSRNOT00000024645
Zfp719
zinc finger protein 719
chr7_+_44009069 2.76 ENSRNOT00000005523
Mgat4c
MGAT4 family, member C
chr12_+_22259713 2.75 ENSRNOT00000001913
Pop7
POP7 homolog, ribonuclease P/MRP subunit
chr7_-_140437467 2.75 ENSRNOT00000087181
Fkbp11
FK506 binding protein 11
chr20_+_27954433 2.24 ENSRNOT00000064288
Lims1
LIM zinc finger domain containing 1
chr7_-_15821927 2.06 ENSRNOT00000050658
LOC691422
similar to zinc finger protein 101
chr2_+_22909569 2.04 ENSRNOT00000073871
Homer1
homer scaffolding protein 1
chr2_-_117454769 1.80 ENSRNOT00000068381
Mecom
MDS1 and EVI1 complex locus
chr8_+_18992899 1.55 ENSRNOT00000061326
Olr1129
olfactory receptor 1129
chr1_+_170109291 1.37 ENSRNOT00000041317
Olr198
olfactory receptor 198
chr1_+_88451958 1.34 ENSRNOT00000074301
LOC102549115
zinc finger protein 260-like
chr1_-_80221417 1.32 ENSRNOT00000072149
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
chr1_-_80221710 1.19 ENSRNOT00000091687
Fosb
FosB proto-oncogene, AP-1 transcription factor subunit
chr13_+_52976507 1.08 ENSRNOT00000090599
ENSRNOT00000011324
Kif21b
kinesin family member 21B
chr2_-_250600517 0.96 ENSRNOT00000016872
Hs2st1
heparan sulfate 2-O-sulfotransferase 1
chr18_+_76559811 0.73 ENSRNOT00000084621
Pard6g
par-6 family cell polarity regulator gamma
chr16_-_20641908 0.61 ENSRNOT00000026846
Ell
elongation factor for RNA polymerase II
chr1_+_170147300 0.54 ENSRNOT00000048075
Olr200
olfactory receptor 200
chr13_-_98529040 0.53 ENSRNOT00000091715
Psen2
presenilin 2
chr9_+_65110330 0.37 ENSRNOT00000033068
ENSRNOT00000092868
Aox4
aldehyde oxidase 4
chr1_+_230217215 0.34 ENSRNOT00000072772
LOC687088
similar to olfactory receptor 1467
chr1_-_224986291 0.28 ENSRNOT00000026284
Taf6l
TATA-box binding protein associated factor 6 like
chr8_-_60752047 0.27 ENSRNOT00000048115
AABR07070238.2

chr1_+_169616178 0.26 ENSRNOT00000023170
Olr157
olfactory receptor 157
chr11_+_43699020 0.06 ENSRNOT00000070849
Olr1559
olfactory receptor 1559
chr11_+_28780446 0.05 ENSRNOT00000072546
Krtap15-1
keratin associated protein 15-1

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox8

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 7.8 GO:0021776 smoothened signaling pathway involved in ventral spinal cord interneuron specification(GO:0021775) smoothened signaling pathway involved in spinal cord motor neuron cell fate specification(GO:0021776)
1.5 7.6 GO:0007207 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207)
1.2 9.9 GO:0007262 STAT protein import into nucleus(GO:0007262)
1.2 16.8 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
1.0 12.0 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.5 7.9 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.3 1.0 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.3 4.0 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260) negative regulation of voltage-gated potassium channel activity(GO:1903817)
0.3 2.2 GO:2000346 negative regulation of hepatocyte proliferation(GO:2000346)
0.2 1.8 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 2.0 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.1 0.6 GO:0042796 snRNA transcription from RNA polymerase III promoter(GO:0042796)
0.1 0.4 GO:0009115 xanthine catabolic process(GO:0009115)
0.1 2.8 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.1 0.5 GO:0007220 Notch receptor processing(GO:0007220)
0.0 2.5 GO:0051412 response to corticosterone(GO:0051412)
0.0 2.8 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
0.0 7.9 GO:0016567 protein ubiquitination(GO:0016567)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 16.8 GO:0035686 sperm fibrous sheath(GO:0035686)
0.4 7.6 GO:0032279 asymmetric synapse(GO:0032279)
0.2 7.8 GO:0016592 mediator complex(GO:0016592)
0.2 0.6 GO:0035363 histone locus body(GO:0035363)
0.1 7.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.1 11.9 GO:0005901 caveola(GO:0005901)
0.0 2.0 GO:0043034 costamere(GO:0043034)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 0.3 GO:0030914 STAGA complex(GO:0030914)
0.0 16.7 GO:0030425 dendrite(GO:0030425)
0.0 0.5 GO:0005637 nuclear inner membrane(GO:0005637)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.4 16.8 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
2.0 7.9 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
1.5 7.6 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
1.3 11.9 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.4 2.0 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.3 12.0 GO:0043015 gamma-tubulin binding(GO:0043015)
0.3 2.8 GO:0004526 ribonuclease P activity(GO:0004526)
0.2 7.8 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.1 0.4 GO:0004031 aldehyde oxidase activity(GO:0004031) xanthine dehydrogenase activity(GO:0004854) oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor(GO:0016726)
0.1 1.0 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.1 2.8 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)
0.0 7.9 GO:0016874 ligase activity(GO:0016874)
0.0 0.5 GO:0004190 aspartic-type endopeptidase activity(GO:0004190)
0.0 2.8 GO:0016758 transferase activity, transferring hexosyl groups(GO:0016758)
0.0 1.1 GO:0003777 microtubule motor activity(GO:0003777)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 11.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.2 16.8 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.1 7.8 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.0 2.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 2.5 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID LKB1 PATHWAY LKB1 signaling events

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.6 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.4 11.9 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.4 16.8 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.2 7.6 REACTOME AMINE LIGAND BINDING RECEPTORS Genes involved in Amine ligand-binding receptors
0.1 2.2 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 0.5 REACTOME REGULATED PROTEOLYSIS OF P75NTR Genes involved in Regulated proteolysis of p75NTR
0.0 1.0 REACTOME HS GAG BIOSYNTHESIS Genes involved in HS-GAG biosynthesis
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.6 REACTOME ELONGATION ARREST AND RECOVERY Genes involved in Elongation arrest and recovery