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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox7

Z-value: 0.49

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Transcription factors associated with Sox7

Gene Symbol Gene ID Gene Info
Sox7
ENSRNOG00000012049 SRY box 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox7rn6_v1_chr15_+_47293699_47293699-0.099.1e-02Click!

Activity profile of Sox7 motif

Sorted Z-values of Sox7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr16_-_75481115 15.43 ENSRNOT00000035128
Defa7
defensin alpha 7
chr16_-_75340360 13.61 ENSRNOT00000018501
Defa5
defensin alpha 5
chr18_+_25749098 11.32 ENSRNOT00000027771
Camk4
calcium/calmodulin-dependent protein kinase IV
chr15_+_30270740 9.42 ENSRNOT00000070991
AABR07017707.1

chr9_-_84894599 9.24 ENSRNOT00000018423
Hdac1l
histone deacetylase 1-like
chr15_+_31948035 8.65 ENSRNOT00000071627
AABR07017868.1

chr18_+_63599425 7.45 ENSRNOT00000023145
Cep192
centrosomal protein 192
chr10_-_49192693 7.42 ENSRNOT00000004294
Zfp286a
zinc finger protein 286A
chr15_-_29532988 7.07 ENSRNOT00000074782
AABR07017639.1

chr1_+_32221636 6.47 ENSRNOT00000022346
ENSRNOT00000089941
Slc6a18
solute carrier family 6 member 18
chr1_+_201672528 6.46 ENSRNOT00000093490
Dmbt1
deleted in malignant brain tumors 1
chr1_+_199596024 5.28 ENSRNOT00000085336
Itgad
integrin subunit alpha D
chr3_-_121882726 5.24 ENSRNOT00000006308
Il1b
interleukin 1 beta
chr14_+_91557601 5.12 ENSRNOT00000038733
RGD1309870
hypothetical LOC289778
chr2_+_60920257 4.65 ENSRNOT00000025170
C1qtnf3
C1q and tumor necrosis factor related protein 3
chr5_-_58950373 4.63 ENSRNOT00000060442
Cd72
Cd72 molecule
chr3_+_2504694 4.34 ENSRNOT00000061987
Tmem210
transmembrane protein 210
chr15_+_31579478 4.17 ENSRNOT00000071642
AABR07017830.1

chr17_-_14373983 4.17 ENSRNOT00000071112
AABR07027098.1

chr20_-_32139789 4.14 ENSRNOT00000078140
Srgn
serglycin
chr5_+_131920155 4.12 ENSRNOT00000064863
Skint1
selection and upkeep of intraepithelial T cells 1
chr6_-_114476723 4.02 ENSRNOT00000005162
Dio2
deiodinase, iodothyronine, type II
chr17_-_10622226 3.90 ENSRNOT00000044559
Simc1
SUMO-interacting motifs containing 1
chr17_-_14949064 3.81 ENSRNOT00000079489
ENSRNOT00000081454
AABR07027128.1

chr9_+_27343853 3.71 ENSRNOT00000072794
Tmem14a
transmembrane protein 14A
chrX_+_144994139 3.65 ENSRNOT00000071783
LOC102546596
pre-mRNA-splicing factor CWC22 homolog
chrX_-_106066227 3.62 ENSRNOT00000033752
Nxf7
nuclear RNA export factor 7
chr3_-_8766433 3.52 ENSRNOT00000021865
Kyat1
kynurenine aminotransferase 1
chr20_+_13498926 3.43 ENSRNOT00000070992
ENSRNOT00000045375
Slc5a4b
solute carrier family 5 (neutral amino acid transporters, system A), member 4b
chr1_+_97777685 3.23 ENSRNOT00000030895
LOC690284
similar to F49E2.5d
chr5_+_4393472 3.03 ENSRNOT00000082717
Eya1
EYA transcriptional coactivator and phosphatase 1
chr16_+_52024690 2.95 ENSRNOT00000048104
AABR07025825.1

chr10_+_17261541 2.94 ENSRNOT00000005478
Sh3pxd2b
SH3 and PX domains 2B
chr7_+_40316639 2.90 ENSRNOT00000080150
LOC500827
similar to hypothetical protein FLJ35821
chr19_+_22569999 2.78 ENSRNOT00000022573
Dnaja2
DnaJ heat shock protein family (Hsp40) member A2
chr3_+_102456938 2.77 ENSRNOT00000051827
Olr748
olfactory receptor 748
chrX_-_82418425 2.72 ENSRNOT00000022525
Ankra2
ankyrin repeat family A member 2
chrX_-_153878806 2.67 ENSRNOT00000087990
Aff2
AF4/FMR2 family, member 2
chr19_+_37852659 2.62 ENSRNOT00000030967
Nrn1l
neuritin 1-like
chr19_+_37852833 2.61 ENSRNOT00000006345
Nrn1l
neuritin 1-like
chr2_-_78427751 2.60 ENSRNOT00000077768
AC113901.1

chr11_-_2813912 2.50 ENSRNOT00000070883
RGD1561853
similar to SET domain-containing protein
chr15_+_30440677 2.43 ENSRNOT00000085402
AABR07017737.1

chr6_+_18880737 2.23 ENSRNOT00000003432
Alkbh8
alkB homolog 8, tRNA methyltransferase
chr6_-_135251073 2.08 ENSRNOT00000088986
Mok
MOK protein kinase
chr1_+_101412736 2.00 ENSRNOT00000067468
Lhb
luteinizing hormone beta polypeptide
chrX_+_114930457 1.83 ENSRNOT00000089141
Pak3
p21 (RAC1) activated kinase 3
chr6_+_26566494 1.83 ENSRNOT00000079292
Gtf3c2
general transcription factor IIIC subunit 2
chr20_+_1837976 1.75 ENSRNOT00000084564
Olr1742
olfactory receptor 1742
chr4_+_102643934 1.67 ENSRNOT00000058389
LOC100911032
uncharacterized LOC100911032
chrX_-_107442878 1.65 ENSRNOT00000052302
Glra4
glycine receptor, alpha 4
chr10_+_39850818 1.62 ENSRNOT00000012671
Fnip1
folliculin interacting protein 1
chr3_-_6054483 1.60 ENSRNOT00000084491
Brd3
bromodomain containing 3
chr18_+_30487264 1.57 ENSRNOT00000040125
Pcdhb10
protocadherin beta 10
chr4_-_103050006 1.42 ENSRNOT00000092130
LOC100911032
uncharacterized LOC100911032
chr10_+_45798797 1.31 ENSRNOT00000039012
Jmjd4
jumonji domain containing 4
chr1_-_73399377 1.30 ENSRNOT00000038898
Lilrb4
leukocyte immunoglobulin like receptor B4
chrX_+_57870445 1.28 ENSRNOT00000065038
Ppp4r3c
protein phosphatase 4 regulatory subunit 3C
chr20_-_7482747 1.19 ENSRNOT00000038195
Taf11
TATA-box binding protein associated factor 11
chr1_+_167758636 1.18 ENSRNOT00000024957
Olr46
olfactory receptor 46
chr1_-_104024682 1.16 ENSRNOT00000056081
Mrgprx1
MAS-related GPR, member X1
chr3_+_138398011 1.15 ENSRNOT00000038865
Mgme1
mitochondrial genome maintenance exonuclease 1
chr7_-_104486710 1.15 ENSRNOT00000084764
Gsdmc
gasdermin C
chr3_+_102471249 1.13 ENSRNOT00000051083
Olr749
olfactory receptor 749
chr3_+_20007192 1.13 ENSRNOT00000075229
AABR07051716.1

chr4_-_87982729 1.08 ENSRNOT00000089498
Vom1r79
vomeronasal 1 receptor 79
chr8_+_113939886 1.07 ENSRNOT00000079562
Aste1
asteroid homolog 1 (Drosophila)
chr1_+_224927764 1.01 ENSRNOT00000050814
AC099294.1

chr17_-_69460321 0.99 ENSRNOT00000058367
Akr1c1
aldo-keto reductase family 1, member C1
chr11_+_43161181 0.89 ENSRNOT00000071470
Olr1530
olfactory receptor 1530
chr4_+_31333970 0.88 ENSRNOT00000064866
LOC100911994
coiled-coil domain-containing protein 132-like
chr9_-_17880706 0.87 ENSRNOT00000031549
Aars2
alanyl-tRNA synthetase 2, mitochondrial
chr11_+_72044096 0.86 ENSRNOT00000034757
Senp5
SUMO1/sentrin specific peptidase 5
chr9_-_44560837 0.78 ENSRNOT00000090870
Mitd1
microtubule interacting and trafficking domain containing 1
chr2_+_194557986 0.78 ENSRNOT00000070843
LOC100911679
TD and POZ domain-containing protein 2-like
chr1_+_101055622 0.77 ENSRNOT00000079189
Nosip
nitric oxide synthase interacting protein
chr10_-_13814304 0.75 ENSRNOT00000012203
Dnase1l2
deoxyribonuclease 1 like 2
chr4_+_149908375 0.71 ENSRNOT00000019504
LOC100909657
uncharacterized LOC100909657
chr9_-_44483655 0.60 ENSRNOT00000024959
Mitd1
microtubule interacting and trafficking domain containing 1
chr1_-_60407295 0.54 ENSRNOT00000078350
Vom1r12
vomeronasal 1 receptor 12
chr4_+_155531906 0.54 ENSRNOT00000060937
Nanog
Nanog homeobox
chr11_+_43329700 0.53 ENSRNOT00000060892
Olr1540
olfactory receptor 1540
chr3_-_74545241 0.53 ENSRNOT00000090836
Olr531
olfactory receptor 531
chr8_-_119523964 0.45 ENSRNOT00000081718
Mlh1
mutL homolog 1
chr1_-_60281386 0.41 ENSRNOT00000092184
Vom1r10
vomeronasal 1 receptor 10
chr2_-_34313094 0.41 ENSRNOT00000016863
Ppwd1
peptidylprolyl isomerase domain and WD repeat containing 1
chr1_-_168015148 0.40 ENSRNOT00000020691
Olr50
olfactory receptor 50
chr3_+_148150698 0.38 ENSRNOT00000087075
ENSRNOT00000010251
Hm13
histocompatibility minor 13
chr16_+_55152748 0.36 ENSRNOT00000000121
Fgf20
fibroblast growth factor 20
chr7_-_40316532 0.30 ENSRNOT00000083347
RGD1307947
similar to RIKEN cDNA C430008C19
chrX_+_158569056 0.26 ENSRNOT00000074170
LOC102550080
placenta-specific protein 1-like
chr4_-_167089055 0.18 ENSRNOT00000050409
Tas2r113
taste receptor, type 2, member 113
chr4_-_87873247 0.06 ENSRNOT00000044351
Vom1r77
vomeronasal 1 receptor 77
chr1_+_229066045 0.00 ENSRNOT00000016454
Glyat
glycine-N-acyltransferase

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 5.2 GO:0060557 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559)
1.4 4.1 GO:0033364 mast cell secretory granule organization(GO:0033364)
0.9 2.8 GO:0042197 chlorinated hydrocarbon metabolic process(GO:0042196) halogenated hydrocarbon metabolic process(GO:0042197)
0.9 11.3 GO:0002371 dendritic cell cytokine production(GO:0002371)
0.7 3.5 GO:0097052 L-kynurenine metabolic process(GO:0097052)
0.7 4.7 GO:0070163 adiponectin secretion(GO:0070162) regulation of adiponectin secretion(GO:0070163)
0.6 13.6 GO:0031640 killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364)
0.6 5.3 GO:0010668 ectodermal cell differentiation(GO:0010668)
0.5 2.7 GO:0035063 nuclear speck organization(GO:0035063)
0.5 3.0 GO:0072513 positive regulation of secondary heart field cardioblast proliferation(GO:0072513)
0.5 1.0 GO:0071395 response to jasmonic acid(GO:0009753) cellular response to jasmonic acid stimulus(GO:0071395)
0.5 2.9 GO:0002051 osteoblast fate commitment(GO:0002051) positive regulation of adipose tissue development(GO:1904179)
0.4 4.0 GO:0019336 phenol-containing compound catabolic process(GO:0019336) hormone catabolic process(GO:0042447)
0.4 9.2 GO:0070932 histone H3 deacetylation(GO:0070932)
0.3 6.5 GO:0001833 inner cell mass cell proliferation(GO:0001833)
0.3 4.1 GO:0045059 positive thymic T cell selection(GO:0045059)
0.3 1.6 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.3 3.6 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.2 2.2 GO:0002098 tRNA wobble uridine modification(GO:0002098)
0.2 0.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
0.2 0.4 GO:0043060 meiotic metaphase I plate congression(GO:0043060)
0.1 1.6 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.1 6.5 GO:0006972 hyperosmotic response(GO:0006972)
0.1 1.4 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.4 GO:1904211 membrane protein proteolysis involved in retrograde protein transport, ER to cytosol(GO:1904211)
0.1 3.4 GO:1904659 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.1 1.2 GO:0043504 mitochondrial DNA repair(GO:0043504)
0.1 6.4 GO:0051298 centrosome duplication(GO:0051298)
0.1 0.9 GO:0016926 protein desumoylation(GO:0016926)
0.1 1.2 GO:0043923 positive regulation by host of viral transcription(GO:0043923)
0.1 1.8 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 1.3 GO:0045591 positive regulation of regulatory T cell differentiation(GO:0045591) negative regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902894)
0.1 2.0 GO:0030823 regulation of cGMP metabolic process(GO:0030823)
0.1 0.8 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.1 0.8 GO:0003334 keratinocyte development(GO:0003334)
0.0 1.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 10.6 GO:0042588 zymogen granule(GO:0042588)
0.3 7.5 GO:0000242 pericentriolar material(GO:0000242)
0.3 1.8 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
0.1 5.3 GO:0008305 integrin complex(GO:0008305)
0.1 0.4 GO:0005712 chiasma(GO:0005712) recombination nodule(GO:0005713)
0.1 11.3 GO:0001650 fibrillar center(GO:0001650)
0.1 6.5 GO:0031526 brush border membrane(GO:0031526)
0.1 2.1 GO:0097546 ciliary base(GO:0097546)
0.1 4.6 GO:0005581 collagen trimer(GO:0005581)
0.1 2.9 GO:0002102 podosome(GO:0002102)
0.1 0.4 GO:0098553 integral component of cytoplasmic side of endoplasmic reticulum membrane(GO:0071458) integral component of lumenal side of endoplasmic reticulum membrane(GO:0071556) lumenal side of endoplasmic reticulum membrane(GO:0098553)
0.1 5.2 GO:0005776 autophagosome(GO:0005776)
0.0 0.2 GO:1990393 3M complex(GO:1990393)
0.0 1.2 GO:0005669 transcription factor TFIID complex(GO:0005669)
0.0 1.4 GO:0031902 late endosome membrane(GO:0031902)
0.0 3.0 GO:0032993 protein-DNA complex(GO:0032993)
0.0 3.5 GO:0005759 mitochondrial matrix(GO:0005759)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.5 GO:0070548 L-glutamine aminotransferase activity(GO:0070548)
0.9 11.3 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
0.9 6.5 GO:0035375 zymogen binding(GO:0035375)
0.7 9.2 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.6 2.2 GO:0016300 tRNA (uracil) methyltransferase activity(GO:0016300)
0.5 3.9 GO:0032184 SUMO polymer binding(GO:0032184)
0.3 3.4 GO:0005412 glucose:sodium symporter activity(GO:0005412)
0.3 2.7 GO:0002151 G-quadruplex RNA binding(GO:0002151)
0.3 1.0 GO:0047045 testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045)
0.3 2.9 GO:0016176 superoxide-generating NADPH oxidase activator activity(GO:0016176)
0.3 5.2 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.2 7.5 GO:0003785 actin monomer binding(GO:0003785)
0.2 6.5 GO:0005328 neurotransmitter:sodium symporter activity(GO:0005328)
0.2 1.6 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.2 1.6 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 0.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
0.2 1.8 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 1.2 GO:0008297 single-stranded DNA exodeoxyribonuclease activity(GO:0008297)
0.1 2.7 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 2.8 GO:0001671 ATPase activator activity(GO:0001671)
0.1 1.2 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 0.9 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.1 0.4 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.1 1.6 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.4 GO:0042500 aspartic endopeptidase activity, intramembrane cleaving(GO:0042500)
0.0 4.0 GO:0005518 collagen binding(GO:0005518)
0.0 5.3 GO:0031072 heat shock protein binding(GO:0031072)
0.0 3.0 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 2.0 GO:0005179 hormone activity(GO:0005179)
0.0 0.4 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.0 4.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 2.6 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.4 GO:0003755 peptidyl-prolyl cis-trans isomerase activity(GO:0003755)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 14.0 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.3 5.2 SA MMP CYTOKINE CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.
0.2 5.3 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.1 4.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.1 4.6 PID BCR 5PATHWAY BCR signaling pathway
0.1 1.8 PID P38 ALPHA BETA PATHWAY Regulation of p38-alpha and p38-beta
0.0 6.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 4.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 13.6 REACTOME DEFENSINS Genes involved in Defensins
0.3 11.3 REACTOME CA DEPENDENT EVENTS Genes involved in Ca-dependent events
0.3 6.5 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.3 4.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.3 2.0 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 7.5 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
0.1 4.6 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.1 5.2 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.1 1.8 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
0.0 0.8 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.0 4.1 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.0 0.9 REACTOME MITOCHONDRIAL TRNA AMINOACYLATION Genes involved in Mitochondrial tRNA aminoacylation
0.0 1.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 0.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.0 1.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell