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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox6_Sox9

Z-value: 1.03

Motif logo

Transcription factors associated with Sox6_Sox9

Gene Symbol Gene ID Gene Info
ENSRNOG00000020514 SRY box 6
ENSRNOG00000002607 SRY box 9

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sox9rn6_v1_chr10_+_101288489_1012884890.464.9e-18Click!
Sox6rn6_v1_chr1_+_185863043_1858630430.227.7e-05Click!

Activity profile of Sox6_Sox9 motif

Sorted Z-values of Sox6_Sox9 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_+_35014538 48.64 ENSRNOT00000006341
kinesin family member 5C
chr18_+_79406381 47.86 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr4_-_39102807 44.11 ENSRNOT00000052063
thrombospondin type 1 domain containing 7A
chr5_+_64326733 35.00 ENSRNOT00000065775
transmembrane protein with EGF-like and two follistatin-like domains 1
chr8_+_128824508 34.12 ENSRNOT00000025343
myelin-associated oligodendrocyte basic protein
chr6_+_147876237 32.47 ENSRNOT00000056649
transmembrane protein 196
chr3_+_92640752 32.00 ENSRNOT00000007604
solute carrier family 1 member 2
chr6_+_147876557 30.15 ENSRNOT00000080090
transmembrane protein 196
chr9_-_100253609 25.61 ENSRNOT00000036061
kinesin family member 1A
chr18_+_30562178 24.46 ENSRNOT00000040998
protocadherin beta-16-like
chr7_-_136853957 21.17 ENSRNOT00000008985
neural EGFL like 2
chr15_+_43007908 20.20 ENSRNOT00000084753
ENSRNOT00000091567
ENSRNOT00000087709
stathmin 4
chr18_+_30023828 20.14 ENSRNOT00000079008
protocadherin alpha 4
chr3_-_10602672 19.79 ENSRNOT00000011648
neuronal calcium sensor 1
chr3_-_168018410 19.75 ENSRNOT00000087579
breast carcinoma amplified sequence 1
chr10_+_3411380 19.61 ENSRNOT00000004346
similar to RIKEN cDNA 2900011O08
chr3_+_48082935 18.82 ENSRNOT00000087711
ENSRNOT00000067545
solute carrier family 4 member 10
chr20_+_10123651 17.26 ENSRNOT00000001559
phosphodiesterase 9A
chr2_+_17616401 17.04 ENSRNOT00000064991
EGF like repeats and discoidin domains 3
chr2_+_58448917 15.62 ENSRNOT00000082562
RAN binding protein 3-like
chr10_-_45534570 15.61 ENSRNOT00000058362
gap junction protein, gamma 2
chr7_-_136853154 15.49 ENSRNOT00000087376
neural EGFL like 2
chr18_+_30574627 15.36 ENSRNOT00000060484
protocadherin beta 19
chr4_-_11610518 15.17 ENSRNOT00000066643
membrane associated guanylate kinase, WW and PDZ domain containing 2
chr5_+_152680407 15.05 ENSRNOT00000076864
stathmin 1
chr11_+_74834050 14.95 ENSRNOT00000002333
ATPase 13A4
chr18_+_30387937 14.29 ENSRNOT00000027210
protocadherin beta 4
chr8_-_82533689 14.25 ENSRNOT00000014124
tropomodulin 2
chr3_-_104504204 13.94 ENSRNOT00000049582
ryanodine receptor 3
chr3_-_104502471 13.69 ENSRNOT00000040306
ryanodine receptor 3
chr18_+_30826260 13.31 ENSRNOT00000065235
protocadherin gamma subfamily B, 1
chr18_+_30435119 13.20 ENSRNOT00000027190
protocadherin beta 8
chr2_-_187401786 13.09 ENSRNOT00000025624
hyaluronan and proteoglycan link protein 2
chr16_+_56247659 12.83 ENSRNOT00000017452
tumor suppressor candidate 3
chr10_+_82823918 12.72 ENSRNOT00000005519
sterile alpha motif domain containing 14
chr18_+_15467870 12.54 ENSRNOT00000091696
beta-1,4-galactosyltransferase 6
chr4_-_108008484 12.52 ENSRNOT00000007971
catenin alpha 2
chr4_+_84423653 12.46 ENSRNOT00000012655
chimerin 2
chr14_-_84106997 12.30 ENSRNOT00000065501
oxysterol binding protein 2
chr9_+_6966908 12.21 ENSRNOT00000072796
ST6 beta-galactoside alpha-2,6-sialyltransferase 2
chr14_+_71542057 12.16 ENSRNOT00000082592
ENSRNOT00000083701
ENSRNOT00000084322
prominin 1
chr8_+_113105814 12.07 ENSRNOT00000016749
copine 4
chr6_+_110624856 11.84 ENSRNOT00000014017
vasohibin 1
chr18_+_30550877 11.70 ENSRNOT00000027164
protocadherin beta-7-like
chr1_+_142679345 11.62 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr1_+_177093387 11.54 ENSRNOT00000021858
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr12_+_2534212 11.08 ENSRNOT00000001399
cortexin 1
chr3_+_11114551 11.05 ENSRNOT00000013507
phospholipid phosphatase 7
chrX_+_70596576 10.86 ENSRNOT00000045082
ENSRNOT00000003741
ENSRNOT00000076079
discs large MAGUK scaffold protein 3
chr13_-_111581018 10.83 ENSRNOT00000083072
ENSRNOT00000077981
SERTA domain containing 4
chr13_+_113692131 10.69 ENSRNOT00000057160
CD34 molecule
chr7_-_134722215 10.62 ENSRNOT00000036750
prickle planar cell polarity protein 1
chr6_-_42473738 10.41 ENSRNOT00000033327
potassium voltage-gated channel modifier subfamily F member 1
chr1_+_236580034 10.16 ENSRNOT00000074939
glucosaminyl (N-acetyl) transferase 1, core 2
chr8_-_22270647 10.12 ENSRNOT00000028380
sphingosine-1-phosphate receptor 5
chr6_-_94980004 10.11 ENSRNOT00000006373
reticulon 1
chr18_+_30474947 10.09 ENSRNOT00000027188
protocadherin beta 9
chrX_+_62727755 9.82 ENSRNOT00000077055
phosphate cytidylyltransferase 1, choline, beta
chr9_-_28973246 9.62 ENSRNOT00000091865
ENSRNOT00000015453
regulating synaptic membrane exocytosis 1
chr4_-_184096806 9.55 ENSRNOT00000055433
mKIAA1238 protein-like
chr4_+_158088505 9.43 ENSRNOT00000026643
von Willebrand factor
chr8_-_62987182 9.25 ENSRNOT00000070885
immunoglobulin superfamily containing leucine-rich repeat 2
chrX_+_159158194 9.25 ENSRNOT00000043820
ENSRNOT00000001169
ENSRNOT00000083502
four and a half LIM domains 1
chr1_+_12915734 9.21 ENSRNOT00000089066
taxilin beta
chr9_-_5329305 9.11 ENSRNOT00000078055
solute carrier family 5 member 7
chr14_-_82287108 8.95 ENSRNOT00000023144
fibroblast growth factor receptor 3
chr8_-_87282156 8.86 ENSRNOT00000087874
filamin A interacting protein 1
chr7_-_107223047 8.76 ENSRNOT00000007250
ENSRNOT00000084875
leucine rich repeat containing 6
chr6_+_95205153 8.75 ENSRNOT00000007339
leucine rich repeat containing 9
chr13_+_24823488 8.72 ENSRNOT00000019907
cadherin 20
chr6_-_41039437 8.57 ENSRNOT00000005774
tribbles pseudokinase 2
chr20_+_44521279 8.45 ENSRNOT00000085987
FYN proto-oncogene, Src family tyrosine kinase
chr1_+_268189277 8.39 ENSRNOT00000065001
sortilin-related VPS10 domain containing receptor 3
chr2_-_227207584 8.38 ENSRNOT00000065361
ENSRNOT00000080215
myozenin 2
chr6_+_55371738 8.32 ENSRNOT00000006652
anterior gradient 3, protein disulphide isomerase family member
chr2_-_62634785 8.30 ENSRNOT00000017937
PDZ domain containing 2
chr2_-_96520137 8.28 ENSRNOT00000066966
zinc finger, C2HC-type containing 1A
chr19_+_27404712 8.00 ENSRNOT00000023657
myosin light chain kinase 3
chr2_-_117454769 7.93 ENSRNOT00000068381
MDS1 and EVI1 complex locus
chr19_-_26053762 7.51 ENSRNOT00000004646
microtubule associated serine/threonine kinase 1
chrX_-_134866210 7.46 ENSRNOT00000005331
apelin
chr10_-_103340922 7.23 ENSRNOT00000004191
BTB domain containing 17
chr2_-_28799266 7.22 ENSRNOT00000089293
transmembrane protein 171
chr8_-_39551700 7.15 ENSRNOT00000091894
ENSRNOT00000076025
PBX/knotted 1 homeobox 2
chr3_+_176102351 7.01 ENSRNOT00000013105
collagen type IX alpha 3 chain
chr18_+_30909490 7.01 ENSRNOT00000026967
protocadherin gamma subfamily B, 8
chr18_+_29993361 6.98 ENSRNOT00000075810
protocadherin alpha 4
chr8_+_69971778 6.77 ENSRNOT00000058007
ENSRNOT00000037941
ENSRNOT00000050649
multiple EGF-like-domains 11
chrX_-_105622156 6.75 ENSRNOT00000029511
armadillo repeat containing, X-linked 2
chr11_+_86520992 6.72 ENSRNOT00000040954
glycoprotein Ib platelet beta subunit
chr5_+_58661049 6.72 ENSRNOT00000078274
unc-13 homolog B
chr1_+_234363994 6.66 ENSRNOT00000018137
RAR-related orphan receptor B
chr12_-_13668515 6.60 ENSRNOT00000086847
fascin actin-bundling protein 1
chr7_-_70467915 6.34 ENSRNOT00000088995
solute carrier family 26, member 10
chr3_+_2396143 6.21 ENSRNOT00000012388
Notch-regulated ankyrin repeat protein
chr10_-_90393317 6.14 ENSRNOT00000028563
family with sequence similarity 171, member A2
chr16_-_71319449 6.07 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr18_+_30913842 6.01 ENSRNOT00000026947
protocadherin gamma subfamily C, 3
chr9_-_28972835 6.01 ENSRNOT00000086967
ENSRNOT00000079684
regulating synaptic membrane exocytosis 1
chrX_-_115175299 5.96 ENSRNOT00000074322
doublecortin
chr18_+_30869628 5.89 ENSRNOT00000060470
protocadherin gamma subfamily B, 4
chr9_-_80167033 5.75 ENSRNOT00000023530
insulin-like growth factor binding protein 5
chr11_+_16826399 5.69 ENSRNOT00000050701
coxsackie virus and adenovirus receptor
chr17_-_81187739 5.65 ENSRNOT00000063911
3-hydroxyacyl-CoA dehydratase 1
chr18_+_30880020 5.63 ENSRNOT00000060468
protocadherin gamma subfamily B, 5
chr5_+_104394119 5.60 ENSRNOT00000093557
ENSRNOT00000093462
ADAMTS-like 1
chr16_+_39909270 5.60 ENSRNOT00000081994
WD repeat domain 17
chr6_+_44225233 5.53 ENSRNOT00000066593
kinase D-interacting substrate 220
chr14_+_114126943 5.51 ENSRNOT00000041638
ENSRNOT00000006443
ENSRNOT00000006957
reticulon 4
chr4_+_113968995 5.48 ENSRNOT00000079511
rhotekin
chr7_-_63407241 5.47 ENSRNOT00000024679
TBC1 domain family, member 30
chr7_-_107768072 5.45 ENSRNOT00000093189
N-myc downstream regulated 1
chr2_+_208749996 5.33 ENSRNOT00000086321
chitinase, acidic
chr18_-_38088457 5.31 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr6_-_1942972 5.30 ENSRNOT00000048711
CDC42 effector protein 3
chr18_+_30890869 5.29 ENSRNOT00000060466
protocadherin gamma subfamily B, 6
chr19_+_56220755 5.28 ENSRNOT00000023452
tubulin, beta 3 class III
chrX_+_28593405 5.24 ENSRNOT00000071708
thymosin beta 4, X-linked
chr16_+_2670618 5.17 ENSRNOT00000030102
interleukin 17 receptor D
chr7_-_15301382 5.16 ENSRNOT00000081512
zinc finger protein 763
chr15_+_41927241 5.03 ENSRNOT00000012035
tripartite motif-containing 13
chr5_+_90338795 4.96 ENSRNOT00000077864
ENSRNOT00000058882
similar to RIKEN cDNA 2310003M01
chr2_+_203768117 4.92 ENSRNOT00000080176
immunoglobulin superfamily, member 3
chr18_+_30875011 4.76 ENSRNOT00000027009
protocadherin gamma subfamily A, 8
chr14_-_44845218 4.67 ENSRNOT00000004003
kelch-like family member 5
chr4_-_88565292 4.61 ENSRNOT00000008948
LanC like 2
chr14_+_84150908 4.58 ENSRNOT00000005516
dual specificity phosphatase 18
chr16_-_19791832 4.44 ENSRNOT00000040393
USH1 protein network component harmonin binding protein 1
chr13_+_106751625 4.36 ENSRNOT00000004992
usherin
chr18_+_30900291 4.33 ENSRNOT00000060461
protocadherin gamma subfamily B, 7
chr4_+_83713666 4.32 ENSRNOT00000086473
cAMP responsive element binding protein 5
chr16_-_71319052 4.25 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr3_+_103773459 4.19 ENSRNOT00000079727
solute carrier family 12, member 6
chr5_+_78483893 4.05 ENSRNOT00000059183
ENSRNOT00000059181
regulator of G-protein signaling 3
chrX_+_33443186 3.86 ENSRNOT00000005622
S100 calcium binding protein G
chr20_+_42966140 3.86 ENSRNOT00000000707
myristoylated alanine rich protein kinase C substrate
chr20_-_38985036 3.78 ENSRNOT00000001066
serine incorporator 1
chr1_-_126211439 3.78 ENSRNOT00000014988
tight junction protein 1
chr10_+_92018562 3.77 ENSRNOT00000006483
ADP-ribosylation factor 2
chr3_+_3767394 3.70 ENSRNOT00000067840
G-protein signaling modulator 1
chr14_-_72122158 3.68 ENSRNOT00000064495
C1q and tumor necrosis factor related protein 7
chr1_-_167911961 3.60 ENSRNOT00000025097
olfactory receptor 59
chrX_+_40363646 3.59 ENSRNOT00000010135
spermine synthase
chr7_-_140640953 3.58 ENSRNOT00000083156
tubulin, alpha 1A
chr3_+_123031307 3.52 ENSRNOT00000080379
protein tyrosine phosphatase, receptor type, A
chrX_+_65566047 3.51 ENSRNOT00000092103
hephaestin
chr13_-_95250235 3.49 ENSRNOT00000085648
AKT serine/threonine kinase 3
chr3_+_116899878 3.48 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr6_-_51019407 3.46 ENSRNOT00000011659
G protein-coupled receptor 22
chr3_-_160038078 3.41 ENSRNOT00000013445
serine incorporator 3
chr17_+_23116661 3.38 ENSRNOT00000067374
neural precursor cell expressed, developmentally down-regulated 9
chr18_+_25613831 3.28 ENSRNOT00000091040
thymic stromal lymphopoietin
chr20_+_48335540 3.21 ENSRNOT00000000352
CD24 molecule
chr5_+_113725717 3.11 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr17_+_18151982 3.10 ENSRNOT00000066447
kinesin family member 13A
chr1_+_13595295 3.09 ENSRNOT00000079250
NHS-like 1
chr11_+_57265732 3.02 ENSRNOT00000093174
pleckstrin homology-like domain, family B, member 2
chr6_-_79306443 3.01 ENSRNOT00000030706
C-type lectin domain family 14, member A
chr7_+_120891940 3.00 ENSRNOT00000018787
chibby family member 1, beta catenin antagonist
chr9_+_47134034 2.98 ENSRNOT00000020108
interleukin 1 receptor-like 1
chr5_-_124642569 2.96 ENSRNOT00000010680
protein kinase AMP-activated catalytic subunit alpha 2
chr8_-_109576353 2.94 ENSRNOT00000010320
protein phosphatase 2, regulatory subunit B'', alpha
chr14_-_81399353 2.89 ENSRNOT00000018340
adducin 1
chr1_+_264741911 2.85 ENSRNOT00000019956
semaphorin 4G
chr7_-_59514939 2.82 ENSRNOT00000085579
potassium calcium-activated channel subfamily M regulatory beta subunit 4
chr3_-_8615532 2.79 ENSRNOT00000021132
WD repeat domain 34
chr4_-_72143748 2.77 ENSRNOT00000024428
TRPM8 channel-associated factor 1
chr13_+_51972974 2.77 ENSRNOT00000008164
ADP-ribosylation factor like GTPase 8A
chr12_-_31629881 2.72 ENSRNOT00000001238
piwi-like RNA-mediated gene silencing 1
chr2_+_22909569 2.72 ENSRNOT00000073871
homer scaffolding protein 1
chr2_-_158156444 2.61 ENSRNOT00000088559
ventricular zone expressed PH domain-containing 1
chr8_+_113939886 2.57 ENSRNOT00000079562
asteroid homolog 1 (Drosophila)
chr1_-_277902279 2.55 ENSRNOT00000078416
actin-binding LIM protein 1
chr18_+_60392376 2.55 ENSRNOT00000023890
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr15_+_7871497 2.46 ENSRNOT00000046879
ubiquitin-conjugating enzyme E2E 2
chr12_+_10254951 2.43 ENSRNOT00000061129
G protein-coupled receptor 12
chr1_+_264059374 2.33 ENSRNOT00000075397
stearoyl-Coenzyme A desaturase 2
chrX_+_152885246 2.27 ENSRNOT00000087074

chr14_-_6786144 2.23 ENSRNOT00000091558
matrix extracellular phosphoglycoprotein
chr6_+_132510757 2.18 ENSRNOT00000080230
Enah/Vasp-like
chr18_-_26211445 2.17 ENSRNOT00000027739
neuronal regeneration related protein
chr18_-_16497886 2.13 ENSRNOT00000021624
regulation of nuclear pre-mRNA domain containing 1A
chr14_+_81858737 2.13 ENSRNOT00000029784
ENSRNOT00000058068
ENSRNOT00000058067
DNA polymerase nu
chr3_+_148510779 2.06 ENSRNOT00000012156
XK related 7
chr3_-_137969658 2.06 ENSRNOT00000007727
beaded filament structural protein 1
chr4_-_166803127 1.98 ENSRNOT00000067909
LOC362451
chr6_+_91595823 1.95 ENSRNOT00000006223
kelch domain containing 2
chr3_+_20993205 1.94 ENSRNOT00000010465
olfactory receptor 419
chr3_+_155160481 1.90 ENSRNOT00000021133
protein phosphatase 1, regulatory subunit 16B
chr5_+_133865331 1.85 ENSRNOT00000035409
TAL bHLH transcription factor 1, erythroid differentiation factor
chr14_-_84189266 1.84 ENSRNOT00000005934
transcobalamin 2
chr6_-_135877883 1.81 ENSRNOT00000079092

chr10_-_74119009 1.79 ENSRNOT00000085712
ENSRNOT00000006926
DEAH-box helicase 40
chr2_+_189865915 1.78 ENSRNOT00000077362
interleukin enhancer binding factor 2
chr10_-_16731898 1.76 ENSRNOT00000028186
CREB3 regulatory factor
chr9_-_14551519 1.75 ENSRNOT00000067623
O-acyl-ADP-ribose deacylase 1
chr10_+_82775691 1.72 ENSRNOT00000030737
histone linker H1 domain, spermatid-specific 1
chr14_-_104960141 1.68 ENSRNOT00000056944
aftiphilin
chrX_-_157172068 1.66 ENSRNOT00000087962
dual specificity phosphatase 9
chr5_+_173340487 1.64 ENSRNOT00000078306
ArfGAP with coiled-coil, ankyrin repeat and PH domains 3

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox6_Sox9

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
16.0 47.9 GO:1904209 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
12.2 48.6 GO:0098963 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
6.4 32.0 GO:0070777 D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779)
5.2 15.6 GO:0031632 positive regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031632)
4.9 19.6 GO:1903976 negative regulation of glial cell migration(GO:1903976)
3.8 11.5 GO:0019417 sulfur oxidation(GO:0019417)
3.8 15.4 GO:0072139 glomerular parietal epithelial cell differentiation(GO:0072139)
3.6 10.7 GO:0072209 mesangial cell-matrix adhesion(GO:0035759) positive regulation of granulocyte colony-stimulating factor production(GO:0071657) metanephric mesangial cell differentiation(GO:0072209) metanephric glomerular mesangial cell differentiation(GO:0072254) positive regulation of macrophage colony-stimulating factor production(GO:1901258)
3.4 10.3 GO:0048377 lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378)
3.1 36.7 GO:0046543 development of secondary female sexual characteristics(GO:0046543)
3.0 11.8 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
2.1 8.6 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
1.9 15.2 GO:0097118 neuroligin clustering involved in postsynaptic membrane assembly(GO:0097118)
1.9 5.7 GO:0071529 cementum mineralization(GO:0071529)
1.9 7.5 GO:0043397 corticotropin-releasing hormone secretion(GO:0043396) regulation of corticotropin-releasing hormone secretion(GO:0043397)
1.8 9.1 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
1.8 8.9 GO:0061144 alveolar secondary septum development(GO:0061144)
1.8 14.2 GO:0051694 pointed-end actin filament capping(GO:0051694)
1.7 6.7 GO:0010808 positive regulation of synaptic vesicle priming(GO:0010808)
1.6 13.1 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
1.6 8.0 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
1.5 4.6 GO:1901421 positive regulation of response to alcohol(GO:1901421)
1.4 5.7 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.4 8.4 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
1.4 4.2 GO:0071477 hypotonic salinity response(GO:0042539) cellular hypotonic salinity response(GO:0071477)
1.4 12.5 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
1.3 17.3 GO:0046069 cGMP catabolic process(GO:0046069)
1.3 3.8 GO:1904219 regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904217) positive regulation of CDP-diacylglycerol-serine O-phosphatidyltransferase activity(GO:1904219) positive regulation of serine C-palmitoyltransferase activity(GO:1904222)
1.2 23.4 GO:0021860 pyramidal neuron development(GO:0021860)
1.2 3.6 GO:1900135 positive regulation of renin secretion into blood stream(GO:1900135)
1.2 10.6 GO:0051890 regulation of cardioblast differentiation(GO:0051890)
1.1 3.4 GO:0009597 detection of virus(GO:0009597)
1.1 9.8 GO:1904116 response to vasopressin(GO:1904116)
1.1 5.3 GO:0006030 chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032)
1.0 9.4 GO:0070417 cellular response to cold(GO:0070417)
1.0 3.1 GO:0048014 Tie signaling pathway(GO:0048014)
1.0 3.0 GO:0038172 interleukin-33-mediated signaling pathway(GO:0038172)
1.0 10.9 GO:0046710 GDP metabolic process(GO:0046710)
1.0 2.9 GO:0090249 cell motility involved in somitogenic axis elongation(GO:0090247) regulation of cell motility involved in somitogenic axis elongation(GO:0090249)
1.0 8.8 GO:0060287 epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287)
1.0 143.0 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
1.0 27.6 GO:0051481 negative regulation of cytosolic calcium ion concentration(GO:0051481)
0.9 5.7 GO:0098904 regulation of AV node cell action potential(GO:0098904)
0.9 6.6 GO:0030035 microspike assembly(GO:0030035) cellular response to cell-matrix adhesion(GO:0071460)
0.9 10.2 GO:0060352 cell adhesion molecule production(GO:0060352)
0.9 12.8 GO:0015693 magnesium ion transport(GO:0015693) magnesium ion transmembrane transport(GO:1903830)
0.9 6.0 GO:0021553 olfactory nerve development(GO:0021553)
0.8 15.0 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.8 12.5 GO:0006688 glycosphingolipid biosynthetic process(GO:0006688)
0.8 3.9 GO:1900020 regulation of protein kinase C activity(GO:1900019) positive regulation of protein kinase C activity(GO:1900020)
0.8 3.0 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.7 5.2 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.7 8.1 GO:0002043 blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:0002043)
0.7 12.5 GO:0001675 acrosome assembly(GO:0001675)
0.7 2.9 GO:1903142 positive regulation of endothelial cell development(GO:1901552) positive regulation of establishment of endothelial barrier(GO:1903142)
0.7 12.2 GO:0097503 sialylation(GO:0097503)
0.7 10.1 GO:0003376 sphingosine-1-phosphate signaling pathway(GO:0003376)
0.6 2.5 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.6 4.4 GO:0048496 maintenance of organ identity(GO:0048496)
0.6 1.9 GO:0060375 positive regulation of chromatin assembly or disassembly(GO:0045799) regulation of mast cell differentiation(GO:0060375)
0.6 1.8 GO:1902211 regulation of prolactin signaling pathway(GO:1902211)
0.6 2.3 GO:1903964 monounsaturated fatty acid metabolic process(GO:1903964) monounsaturated fatty acid biosynthetic process(GO:1903966)
0.6 3.9 GO:0071000 response to magnetism(GO:0071000)
0.6 15.6 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.6 6.7 GO:0046548 retinal rod cell development(GO:0046548) retinal cone cell development(GO:0046549)
0.5 4.9 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.5 3.1 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.5 12.7 GO:0010832 negative regulation of myotube differentiation(GO:0010832)
0.5 5.5 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.5 8.5 GO:1902358 sulfate transmembrane transport(GO:1902358)
0.5 5.4 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.5 2.5 GO:0032020 ISG15-protein conjugation(GO:0032020)
0.5 5.3 GO:0031274 positive regulation of pseudopodium assembly(GO:0031274)
0.4 4.9 GO:0032808 lacrimal gland development(GO:0032808)
0.4 1.3 GO:0010908 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) regulation of centriole-centriole cohesion(GO:0030997) embryonic skeletal limb joint morphogenesis(GO:0036023) anagen(GO:0042640) regulation of anagen(GO:0051884) oviduct development(GO:0060066) foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492) positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769) fungiform papilla formation(GO:0061198) canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation(GO:0061324) regulation of centromeric sister chromatid cohesion(GO:0070602) renal outer medulla development(GO:0072054) regulation of cell proliferation involved in outflow tract morphogenesis(GO:1901963)
0.4 2.1 GO:0070940 dephosphorylation of RNA polymerase II C-terminal domain(GO:0070940)
0.4 6.8 GO:0010842 retina layer formation(GO:0010842)
0.4 5.5 GO:1902018 negative regulation of cilium assembly(GO:1902018)
0.4 8.4 GO:1900452 regulation of long term synaptic depression(GO:1900452)
0.4 2.8 GO:1901529 positive regulation of anion channel activity(GO:1901529)
0.4 2.7 GO:0010529 regulation of transposition(GO:0010528) negative regulation of transposition(GO:0010529)
0.4 1.8 GO:0015889 cobalamin transport(GO:0015889)
0.4 20.2 GO:0007019 microtubule depolymerization(GO:0007019)
0.4 3.6 GO:0008215 spermine metabolic process(GO:0008215)
0.3 4.6 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.3 1.5 GO:0061303 cornea development in camera-type eye(GO:0061303)
0.3 5.0 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.2 0.7 GO:0034436 glycoprotein transport(GO:0034436)
0.2 1.5 GO:2000303 regulation of sphingolipid biosynthetic process(GO:0090153) regulation of membrane lipid metabolic process(GO:1905038) regulation of ceramide biosynthetic process(GO:2000303)
0.2 9.2 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.2 2.7 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.2 19.8 GO:0045921 positive regulation of exocytosis(GO:0045921)
0.2 2.8 GO:0005513 detection of calcium ion(GO:0005513)
0.2 2.2 GO:1900028 negative regulation of ruffle assembly(GO:1900028)
0.2 3.0 GO:0045821 positive regulation of glycolytic process(GO:0045821)
0.2 9.2 GO:0045773 positive regulation of axon extension(GO:0045773)
0.2 0.5 GO:1902966 protein localization to early endosome(GO:1902946) regulation of protein localization to early endosome(GO:1902965) positive regulation of protein localization to early endosome(GO:1902966)
0.2 3.5 GO:0048714 positive regulation of oligodendrocyte differentiation(GO:0048714)
0.2 0.9 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.2 2.1 GO:0019985 translesion synthesis(GO:0019985)
0.1 17.2 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
0.1 1.4 GO:0031468 nuclear envelope reassembly(GO:0031468)
0.1 2.2 GO:0030502 negative regulation of bone mineralization(GO:0030502)
0.1 25.6 GO:0007018 microtubule-based movement(GO:0007018)
0.1 0.3 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.1 0.3 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141)
0.1 3.5 GO:0021591 ventricular system development(GO:0021591)
0.1 3.5 GO:0048854 brain morphogenesis(GO:0048854)
0.1 3.0 GO:0002042 cell migration involved in sprouting angiogenesis(GO:0002042)
0.1 1.1 GO:0033141 regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033139) positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.1 12.3 GO:0007286 spermatid development(GO:0007286)
0.1 1.7 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.1 1.4 GO:0007035 vacuolar acidification(GO:0007035)
0.1 1.1 GO:0097435 fibril organization(GO:0097435)
0.1 0.6 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
0.1 0.6 GO:0015727 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.1 0.9 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313)
0.1 1.8 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.1 1.7 GO:0030261 chromosome condensation(GO:0030261)
0.1 0.1 GO:0051692 cellular oligosaccharide catabolic process(GO:0051692)
0.1 0.7 GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest(GO:0006977)
0.1 0.4 GO:0002087 regulation of respiratory gaseous exchange by neurological system process(GO:0002087)
0.1 2.2 GO:0031103 axon regeneration(GO:0031103)
0.1 8.7 GO:0071805 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 2.6 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 11.9 GO:0070588 calcium ion transmembrane transport(GO:0070588)
0.0 0.8 GO:0030517 negative regulation of axon extension(GO:0030517)
0.0 1.0 GO:0006221 pyrimidine nucleotide biosynthetic process(GO:0006221)
0.0 0.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 5.0 GO:0060271 cilium morphogenesis(GO:0060271)
0.0 0.3 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.0 3.1 GO:0006874 cellular calcium ion homeostasis(GO:0006874)
0.0 0.9 GO:2000648 positive regulation of stem cell proliferation(GO:2000648)
0.0 0.4 GO:0060416 response to growth hormone(GO:0060416)
0.0 0.4 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.0 1.3 GO:0008585 female gonad development(GO:0008585)
0.0 1.8 GO:0007411 axon guidance(GO:0007411)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
8.0 47.9 GO:0033269 internode region of axon(GO:0033269)
3.2 48.6 GO:0035253 ciliary rootlet(GO:0035253)
3.1 18.8 GO:0097441 basilar dendrite(GO:0097441)
3.1 27.6 GO:0030314 junctional membrane complex(GO:0030314)
3.0 12.2 GO:0071914 prominosome(GO:0071914)
2.3 7.0 GO:0005594 collagen type IX trimer(GO:0005594)
2.2 6.6 GO:0044393 microspike(GO:0044393)
2.0 15.6 GO:0098831 presynaptic active zone cytoplasmic component(GO:0098831)
1.6 9.4 GO:0033093 Weibel-Palade body(GO:0033093)
1.5 15.2 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
1.2 19.8 GO:0031045 dense core granule(GO:0031045)
1.0 3.9 GO:0044307 germinal vesicle(GO:0042585) dendritic branch(GO:0044307)
1.0 6.7 GO:0044305 calyx of Held(GO:0044305)
1.0 5.7 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.9 32.0 GO:0030673 axolemma(GO:0030673)
0.8 12.8 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.7 15.6 GO:0005922 connexon complex(GO:0005922)
0.7 4.4 GO:0002142 stereocilia ankle link complex(GO:0002142) USH2 complex(GO:1990696)
0.6 1.3 GO:0071664 catenin-TCF7L2 complex(GO:0071664)
0.6 4.6 GO:0031314 extrinsic component of mitochondrial inner membrane(GO:0031314)
0.5 12.3 GO:0097440 apical dendrite(GO:0097440)
0.5 28.7 GO:0005871 kinesin complex(GO:0005871)
0.5 1.4 GO:1990730 VCP-NSFL1C complex(GO:1990730)
0.4 9.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.4 1.7 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.4 24.7 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.4 17.8 GO:0045171 intercellular bridge(GO:0045171)
0.4 10.2 GO:0031985 Golgi cisterna(GO:0031985)
0.3 10.9 GO:0032281 AMPA glutamate receptor complex(GO:0032281)
0.3 9.1 GO:0045334 clathrin-coated endocytic vesicle(GO:0045334)
0.3 2.9 GO:0008290 F-actin capping protein complex(GO:0008290)
0.3 2.7 GO:0097433 dense body(GO:0097433)
0.3 5.0 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.2 42.7 GO:0043204 perikaryon(GO:0043204)
0.2 46.9 GO:0043209 myelin sheath(GO:0043209)
0.2 3.0 GO:0045180 basal cortex(GO:0045180)
0.2 36.3 GO:0014069 postsynaptic density(GO:0014069)
0.2 3.2 GO:0031528 microvillus membrane(GO:0031528)
0.2 26.4 GO:0030426 growth cone(GO:0030426)
0.2 13.2 GO:0008076 voltage-gated potassium channel complex(GO:0008076)
0.2 3.0 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.2 5.1 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.2 2.8 GO:0051233 spindle midzone(GO:0051233)
0.2 155.8 GO:0005887 integral component of plasma membrane(GO:0005887)
0.1 3.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.1 9.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.1 3.7 GO:0005581 collagen trimer(GO:0005581)
0.1 2.8 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 1.1 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.8 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 23.5 GO:0005874 microtubule(GO:0005874)
0.1 0.6 GO:0034991 nuclear meiotic cohesin complex(GO:0034991)
0.1 1.7 GO:0001673 male germ cell nucleus(GO:0001673)
0.1 8.5 GO:0036064 ciliary basal body(GO:0036064)
0.1 0.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 4.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 1.0 GO:0034709 methylosome(GO:0034709)
0.1 5.3 GO:0030018 Z disc(GO:0030018)
0.0 1.4 GO:0034707 chloride channel complex(GO:0034707)
0.0 19.2 GO:0031012 extracellular matrix(GO:0031012)
0.0 4.6 GO:0005770 late endosome(GO:0005770)
0.0 3.0 GO:0016323 basolateral plasma membrane(GO:0016323)
0.0 5.3 GO:0005925 focal adhesion(GO:0005925)
0.0 1.3 GO:0000922 spindle pole(GO:0000922)
0.0 4.0 GO:0045177 apical part of cell(GO:0045177)
0.0 8.7 GO:0015630 microtubule cytoskeleton(GO:0015630)
0.0 1.4 GO:0043235 receptor complex(GO:0043235)
0.0 0.2 GO:0060170 ciliary membrane(GO:0060170)
0.0 62.5 GO:0016021 integral component of membrane(GO:0016021)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
6.9 27.6 GO:0005219 ryanodine-sensitive calcium-release channel activity(GO:0005219)
6.8 82.0 GO:0019911 structural constituent of myelin sheath(GO:0019911)
6.4 32.0 GO:0005314 high-affinity glutamate transmembrane transporter activity(GO:0005314)
4.9 19.8 GO:0008427 calcium-dependent protein kinase inhibitor activity(GO:0008427)
4.9 48.6 GO:0034190 apolipoprotein receptor binding(GO:0034190)
4.2 12.5 GO:0001565 phorbol ester receptor activity(GO:0001565)
3.8 15.2 GO:0070699 type II activin receptor binding(GO:0070699)
3.2 9.6 GO:0072590 N-acetyl-L-aspartate-L-glutamate ligase activity(GO:0072590)
3.1 12.5 GO:0008489 UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity(GO:0008489)
3.1 12.2 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
2.2 17.9 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.1 8.4 GO:0042610 CD8 receptor binding(GO:0042610)
2.0 8.0 GO:0004687 myosin light chain kinase activity(GO:0004687)
2.0 9.8 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
1.8 9.1 GO:0015220 choline transmembrane transporter activity(GO:0015220)
1.7 8.4 GO:0051373 FATZ binding(GO:0051373)
1.3 10.7 GO:0043199 sulfate binding(GO:0043199)
1.3 6.7 GO:0008502 melatonin receptor activity(GO:0008502)
1.3 15.6 GO:0005243 gap junction channel activity(GO:0005243)
1.2 17.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
1.2 9.5 GO:0071253 connexin binding(GO:0071253)
1.2 1.2 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
1.1 10.9 GO:0004385 guanylate kinase activity(GO:0004385)
1.0 4.2 GO:0035827 rubidium ion transmembrane transporter activity(GO:0035827)
1.0 10.1 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036)
1.0 11.0 GO:0042577 lipid phosphatase activity(GO:0042577)
1.0 3.0 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.9 5.7 GO:0046848 hydroxyapatite binding(GO:0046848)
0.9 12.8 GO:0004579 oligosaccharyl transferase activity(GO:0004576) dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.9 5.3 GO:0004568 chitinase activity(GO:0004568)
0.8 2.5 GO:0042296 ISG15 transferase activity(GO:0042296)
0.8 14.1 GO:0005523 tropomyosin binding(GO:0005523)
0.7 5.2 GO:1990430 extracellular matrix protein binding(GO:1990430)
0.7 6.7 GO:0019992 diacylglycerol binding(GO:0019992)
0.7 26.1 GO:0015301 anion:anion antiporter activity(GO:0015301)
0.7 5.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.7 2.7 GO:0034584 piRNA binding(GO:0034584)
0.7 15.0 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.7 44.0 GO:0005080 protein kinase C binding(GO:0005080)
0.6 5.2 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.6 3.9 GO:0005499 vitamin D binding(GO:0005499)
0.6 5.7 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.6 7.2 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.6 2.3 GO:0032896 stearoyl-CoA 9-desaturase activity(GO:0004768) palmitoyl-CoA 9-desaturase activity(GO:0032896)
0.5 2.7 GO:0031802 type 5 metabotropic glutamate receptor binding(GO:0031802)
0.5 13.1 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 11.5 GO:0071949 FAD binding(GO:0071949)
0.4 2.9 GO:0042608 T cell receptor binding(GO:0042608)
0.4 2.8 GO:0045503 dynein light chain binding(GO:0045503)
0.4 6.2 GO:0017017 MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017)
0.4 3.1 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.4 8.3 GO:0002162 dystroglycan binding(GO:0002162)
0.3 28.7 GO:0003777 microtubule motor activity(GO:0003777)
0.3 5.3 GO:0017049 GTP-Rho binding(GO:0017049)
0.3 4.6 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.3 2.5 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.3 12.3 GO:0015485 cholesterol binding(GO:0015485)
0.3 1.5 GO:0047493 sphingomyelin synthase activity(GO:0033188) ceramide cholinephosphotransferase activity(GO:0047493)
0.3 3.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.2 3.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 1.6 GO:0043426 MRF binding(GO:0043426)
0.2 3.9 GO:0031210 phosphatidylcholine binding(GO:0031210)
0.2 1.8 GO:0031419 cobalamin binding(GO:0031419)
0.2 1.3 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.2 0.7 GO:0034437 sterol-transporting ATPase activity(GO:0034041) glycoprotein transporter activity(GO:0034437)
0.2 1.3 GO:0017034 Rap guanyl-nucleotide exchange factor activity(GO:0017034)
0.2 10.2 GO:0008375 acetylglucosaminyltransferase activity(GO:0008375)
0.2 3.2 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 3.0 GO:0004679 AMP-activated protein kinase activity(GO:0004679)
0.2 28.9 GO:0044325 ion channel binding(GO:0044325)
0.2 5.4 GO:0043015 gamma-tubulin binding(GO:0043015)
0.2 9.2 GO:0042805 actinin binding(GO:0042805)
0.2 18.7 GO:0005178 integrin binding(GO:0005178)
0.2 6.7 GO:0071855 neuropeptide receptor binding(GO:0071855)
0.2 2.8 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.2 40.9 GO:0015631 tubulin binding(GO:0015631)
0.2 9.2 GO:0019905 syntaxin binding(GO:0019905)
0.2 13.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.2 2.2 GO:0005522 profilin binding(GO:0005522)
0.1 95.5 GO:0005509 calcium ion binding(GO:0005509)
0.1 2.1 GO:0008409 5'-3' exonuclease activity(GO:0008409)
0.1 10.8 GO:0046332 SMAD binding(GO:0046332)
0.1 3.5 GO:0008198 ferrous iron binding(GO:0008198)
0.1 10.4 GO:0005249 voltage-gated potassium channel activity(GO:0005249)
0.1 1.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.1 0.2 GO:0070698 nodal binding(GO:0038100) type I activin receptor binding(GO:0070698)
0.1 9.7 GO:0051015 actin filament binding(GO:0051015)
0.1 4.4 GO:0017022 myosin binding(GO:0017022)
0.1 0.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.1 1.7 GO:0030276 clathrin binding(GO:0030276)
0.1 0.3 GO:0017040 ceramidase activity(GO:0017040)
0.0 1.7 GO:0019213 deacetylase activity(GO:0019213)
0.0 1.0 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 5.5 GO:0017137 Rab GTPase binding(GO:0017137)
0.0 0.2 GO:1903924 estradiol binding(GO:1903924)
0.0 4.0 GO:0030165 PDZ domain binding(GO:0030165)
0.0 2.6 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 0.1 GO:0017042 glycosylceramidase activity(GO:0017042)
0.0 3.6 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 7.4 GO:0000287 magnesium ion binding(GO:0000287)
0.0 0.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.8 GO:0004693 cyclin-dependent protein serine/threonine kinase activity(GO:0004693)
0.0 1.5 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.5 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.0 1.4 GO:0051117 ATPase binding(GO:0051117)
0.0 0.4 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.0 3.3 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
0.0 1.4 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 1.4 GO:0005254 chloride channel activity(GO:0005254)
0.0 1.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 2.6 GO:0004518 nuclease activity(GO:0004518)
0.0 1.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 2.0 GO:0005096 GTPase activator activity(GO:0005096)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 15.0 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
1.1 12.8 PID FGF PATHWAY FGF signaling pathway
0.8 17.0 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.7 10.1 PID S1P S1P4 PATHWAY S1P4 pathway
0.5 19.0 PID GLYPICAN 1PATHWAY Glypican 1 network
0.3 11.3 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.3 17.3 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.3 55.6 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.2 4.3 ST G ALPHA S PATHWAY G alpha s Pathway
0.2 12.5 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.2 4.0 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 6.0 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.2 8.3 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.2 3.6 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 6.3 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.8 PID NEPHRIN NEPH1 PATHWAY Nephrin/Neph1 signaling in the kidney podocyte
0.1 10.2 PID CMYB PATHWAY C-MYB transcription factor network
0.1 3.1 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.1 13.0 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 1.7 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.1 1.4 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.1 3.0 PID VEGFR1 2 PATHWAY Signaling events mediated by VEGFR1 and VEGFR2
0.1 3.5 PID TRKR PATHWAY Neurotrophic factor-mediated Trk receptor signaling
0.1 3.0 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 13.2 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 2.1 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.7 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
3.0 8.9 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
1.5 24.7 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
1.3 19.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.9 15.6 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.8 20.1 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.8 10.3 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.7 12.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.7 10.9 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.6 15.2 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.6 6.7 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.5 8.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.5 24.9 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.5 0.9 REACTOME SIGNALLING TO P38 VIA RIT AND RIN Genes involved in Signalling to p38 via RIT and RIN
0.4 3.5 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.4 9.8 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.4 3.9 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.4 5.1 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.3 3.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.3 5.7 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.3 3.1 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.2 5.0 REACTOME ARMS MEDIATED ACTIVATION Genes involved in ARMS-mediated activation
0.2 10.2 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.2 3.5 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.2 10.4 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.2 3.6 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 12.8 REACTOME ASPARAGINE N LINKED GLYCOSYLATION Genes involved in Asparagine N-linked glycosylation
0.1 2.6 REACTOME DCC MEDIATED ATTRACTIVE SIGNALING Genes involved in DCC mediated attractive signaling
0.1 12.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 1.8 REACTOME BILE SALT AND ORGANIC ANION SLC TRANSPORTERS Genes involved in Bile salt and organic anion SLC transporters
0.1 5.7 REACTOME CELL SURFACE INTERACTIONS AT THE VASCULAR WALL Genes involved in Cell surface interactions at the vascular wall
0.1 9.7 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 2.9 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.7 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.1 1.5 REACTOME KERATAN SULFATE BIOSYNTHESIS Genes involved in Keratan sulfate biosynthesis
0.1 6.8 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 0.9 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
0.1 3.7 REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.1 5.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.2 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.1 0.7 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 10.1 REACTOME G ALPHA I SIGNALLING EVENTS Genes involved in G alpha (i) signalling events
0.1 1.6 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.1 1.6 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 3.8 REACTOME SIGNALING BY FGFR Genes involved in Signaling by FGFR
0.0 0.7 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.0 0.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 1.5 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 0.5 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
0.0 0.2 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.0 0.3 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis