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GSE53960: rat RNA-Seq transcriptomic Bodymap

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Results for Sox5_Sry

Z-value: 0.73

Motif logo

Transcription factors associated with Sox5_Sry

Gene Symbol Gene ID Gene Info
ENSRNOG00000027869 SRY box 5
ENSRNOG00000062090 sex determining region Y

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
Sryrn6_v1_chrY_+_327166_3271660.122.9e-02Click!
Sox5rn6_v1_chr4_-_178441547_1784415470.072.4e-01Click!

Activity profile of Sox5_Sry motif

Sorted Z-values of Sox5_Sry motif

Promoter Log-likelihood Transcript Gene Gene Info
chr3_-_72219246 29.67 ENSRNOT00000009903
smoothelin-like 1
chr7_+_38858062 26.84 ENSRNOT00000006234
keratocan
chr18_-_26211445 17.93 ENSRNOT00000027739
neuronal regeneration related protein
chr4_-_14490446 14.42 ENSRNOT00000009132
semaphorin 3C
chr4_+_44774741 13.74 ENSRNOT00000086902
MET proto-oncogene, receptor tyrosine kinase
chr9_-_53315915 12.88 ENSRNOT00000038093
myostatin
chr18_+_79406381 10.47 ENSRNOT00000022303
ENSRNOT00000058295
ENSRNOT00000058296
ENSRNOT00000022280
myelin basic protein
chr11_+_58624198 10.35 ENSRNOT00000002091
growth associated protein 43
chrX_+_62727755 9.93 ENSRNOT00000077055
phosphate cytidylyltransferase 1, choline, beta
chr11_+_61083757 9.74 ENSRNOT00000002790
BOC cell adhesion associated, oncogene regulated
chr9_+_37727942 9.39 ENSRNOT00000016511
ENSRNOT00000074276
myotilin-like
chr18_+_35574002 9.37 ENSRNOT00000093442
ENSRNOT00000070817
ENSRNOT00000093356
myotilin
chr16_-_6245644 9.23 ENSRNOT00000040759
calcium voltage-gated channel subunit alpha1 D
chr2_-_172361779 8.84 ENSRNOT00000085876
schwannomin interacting protein 1
chr5_+_64326733 7.82 ENSRNOT00000065775
transmembrane protein with EGF-like and two follistatin-like domains 1
chr16_+_3293599 7.79 ENSRNOT00000081999
ENSRNOT00000047118
ENSRNOT00000020427
ELKS/RAB6-interacting/CAST family member 2
chr13_-_68360664 7.64 ENSRNOT00000030971
hemicentin 1
chr1_-_93949187 7.51 ENSRNOT00000018956
zinc finger protein 536
chr7_+_142776252 6.98 ENSRNOT00000008673
activin A receptor like type 1
chr7_+_142776580 6.52 ENSRNOT00000081047
activin A receptor like type 1
chr6_-_125723944 6.31 ENSRNOT00000007004
fibulin 5
chr14_+_114126943 6.19 ENSRNOT00000041638
ENSRNOT00000006443
ENSRNOT00000006957
reticulon 4
chr4_+_155321553 6.16 ENSRNOT00000089614
microfibrillar associated protein 5
chr4_-_119131202 6.05 ENSRNOT00000011675
anthrax toxin receptor 1
chr2_-_113616766 5.78 ENSRNOT00000016858
ENSRNOT00000074723
transmembrane protein 212
chr1_-_126211439 5.73 ENSRNOT00000014988
tight junction protein 1
chr4_-_39102807 5.67 ENSRNOT00000052063
thrombospondin type 1 domain containing 7A
chr7_-_138483612 5.54 ENSRNOT00000085620
solute carrier family 38, member 4
chr1_+_256955652 5.52 ENSRNOT00000020411
leucine-rich, glioma inactivated 1
chr2_+_242634399 5.24 ENSRNOT00000035700
endomucin
chr3_-_123718432 5.23 ENSRNOT00000028861
sperm flagellar 1
chr11_-_35749464 5.17 ENSRNOT00000078818
ENSRNOT00000078425
ERG, ETS transcription factor
chr3_-_51643140 5.02 ENSRNOT00000006646
sodium voltage-gated channel alpha subunit 3
chr5_+_104362971 5.00 ENSRNOT00000058520
ADAMTS-like 1
chr13_-_112099336 4.73 ENSRNOT00000009158
ENSRNOT00000044161
calcium/calmodulin-dependent protein kinase IG
chr9_-_55256340 4.45 ENSRNOT00000028907
serum deprivation response
chr15_+_83703791 4.44 ENSRNOT00000090637
Kruppel-like factor 5
chr18_-_5314511 4.43 ENSRNOT00000022637
ENSRNOT00000079682
zinc finger protein 521
chr2_-_231521052 4.41 ENSRNOT00000089534
ENSRNOT00000080470
ENSRNOT00000084756
ankyrin 2
chr6_-_125723732 4.11 ENSRNOT00000084815
fibulin 5
chr6_+_27768943 4.04 ENSRNOT00000015820
kinesin family member 3C
chr16_+_46731403 4.02 ENSRNOT00000017624
teneurin transmembrane protein 3
chr1_+_234252757 3.89 ENSRNOT00000091814
RAR-related orphan receptor B
chr18_-_38088457 3.87 ENSRNOT00000077814
janus kinase and microtubule interacting protein 2
chr4_-_108008484 3.79 ENSRNOT00000007971
catenin alpha 2
chr6_-_67084234 3.74 ENSRNOT00000050372
NOVA alternative splicing regulator 1
chr11_+_9642365 3.72 ENSRNOT00000087080
ENSRNOT00000042384
roundabout guidance receptor 1
chrX_+_9436707 3.59 ENSRNOT00000004187
calcium/calmodulin dependent serine protein kinase
chr6_+_110624856 3.55 ENSRNOT00000014017
vasohibin 1
chr8_-_84522588 3.43 ENSRNOT00000076213
muscular LMNA-interacting protein
chr8_+_23113048 3.43 ENSRNOT00000029577
calponin 1
chr2_-_35104963 3.35 ENSRNOT00000018058
regulator of G-protein signaling 7-binding protein
chr2_-_63166509 3.27 ENSRNOT00000018246
cadherin 6
chrX_+_40363646 3.27 ENSRNOT00000010135
spermine synthase
chr6_-_106971250 3.18 ENSRNOT00000010926
double PHD fingers 3
chr3_-_168018410 3.00 ENSRNOT00000087579
breast carcinoma amplified sequence 1
chr15_+_33600102 2.99 ENSRNOT00000022664
CKLF-like MARVEL transmembrane domain containing 5
chr4_-_55398941 2.92 ENSRNOT00000075324
glutamate metabotropic receptor 8
chrX_-_115175299 2.88 ENSRNOT00000074322
doublecortin
chr4_-_148711830 2.87 ENSRNOT00000049091
olfactory receptor 832
chr13_-_111581018 2.87 ENSRNOT00000083072
ENSRNOT00000077981
SERTA domain containing 4
chr1_-_90520344 2.86 ENSRNOT00000078598
potassium channel tetramerization domain containing 15
chr7_+_116632506 2.85 ENSRNOT00000009811
glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1
chr2_+_203768117 2.85 ENSRNOT00000080176
immunoglobulin superfamily, member 3
chr18_+_30381322 2.81 ENSRNOT00000027216
protocadherin beta 3
chr18_+_3887419 2.76 ENSRNOT00000093089
laminin subunit alpha 3
chr1_+_241594565 2.71 ENSRNOT00000020123
amyloid beta precursor protein binding family A member 1
chr10_+_23661013 2.70 ENSRNOT00000076664
early B-cell factor 1
chr10_-_46720907 2.68 ENSRNOT00000083093
ENSRNOT00000067866
target of myb1 like 2 membrane trafficking protein
chr15_+_33600337 2.54 ENSRNOT00000075965
CKLF-like MARVEL transmembrane domain containing 5
chr7_+_59326518 2.49 ENSRNOT00000085231
protein tyrosine phosphatase, receptor type, B
chr9_+_67234303 2.49 ENSRNOT00000050179
abl-interactor 2
chr6_-_136436620 2.42 ENSRNOT00000067118
protein phosphatase 1, regulatory subunit 13B
chr15_-_93307420 2.41 ENSRNOT00000012195
SLIT and NTRK-like family, member 1
chr16_-_71319449 2.36 ENSRNOT00000029284
Fibroblast growth factor receptor 1
chr8_-_90664554 2.26 ENSRNOT00000039917
ENSRNOT00000074896
ENSRNOT00000072225
high mobility group nucleosomal binding domain 3
chr2_-_187401786 2.24 ENSRNOT00000025624
hyaluronan and proteoglycan link protein 2
chr5_-_12563429 2.20 ENSRNOT00000059625
suppression of tumorigenicity 18
chr3_+_137618898 2.18 ENSRNOT00000007249
proprotein convertase subtilisin/kexin type 2
chr5_+_113725717 2.17 ENSRNOT00000032248
TEK receptor tyrosine kinase
chr6_-_136436818 2.13 ENSRNOT00000082600
protein phosphatase 1, regulatory subunit 13B
chr3_+_116899878 2.13 ENSRNOT00000090802
ENSRNOT00000066101
semaphorin 6D
chr3_+_35014538 2.11 ENSRNOT00000006341
kinesin family member 5C
chr4_+_158088505 2.10 ENSRNOT00000026643
von Willebrand factor
chr11_-_17684903 2.09 ENSRNOT00000051213
transmembrane protease, serine 15
chr10_-_37455022 2.08 ENSRNOT00000016742
ubiquitin-conjugating enzyme E2 B
chr16_-_71319052 2.06 ENSRNOT00000050980
Fibroblast growth factor receptor 1
chr13_-_95250235 2.04 ENSRNOT00000085648
AKT serine/threonine kinase 3
chr16_-_47535358 2.03 ENSRNOT00000040731
claudin 22
chr10_+_14248399 2.00 ENSRNOT00000077689
splA/ryanodine receptor domain and SOCS box containing 3
chr10_-_34439470 1.96 ENSRNOT00000072081
butyrophilin-like 9
chr8_+_14811627 1.93 ENSRNOT00000043392
LRRGT00142
chrX_+_6273733 1.92 ENSRNOT00000074275
NDP, norrin cystine knot growth factor
chr18_+_65155685 1.89 ENSRNOT00000081797
transcription factor 4
chr14_+_3882398 1.83 ENSRNOT00000033794
HFM1, ATP-dependent DNA helicase homolog
chr10_+_43768708 1.78 ENSRNOT00000086218
SH3 binding domain protein 5 like
chr4_-_115516296 1.74 ENSRNOT00000019399
poly(A) binding protein interacting protein 2B
chr3_-_71845232 1.73 ENSRNOT00000078645
calcitonin receptor like receptor
chr16_+_23668595 1.72 ENSRNOT00000067886
pleckstrin and Sec7 domain containing 3
chr1_-_206282575 1.69 ENSRNOT00000024974
ADAM metallopeptidase domain 12
chr14_+_17492081 1.66 ENSRNOT00000003346
G3BP stress granule assembly factor 2
chr1_+_144070754 1.62 ENSRNOT00000079989
SH3 domain-containing GRB2-like 3
chr8_-_71337746 1.60 ENSRNOT00000021554
zinc finger protein 609
chr6_-_42616548 1.58 ENSRNOT00000081433
ATPase H+ transporting V1 subunit C2
chr6_+_91595823 1.54 ENSRNOT00000006223
kelch domain containing 2
chr6_+_73358112 1.48 ENSRNOT00000041373
Rho GTPase activating protein 5
chr10_+_67862054 1.47 ENSRNOT00000031746
cyclin-dependent kinase 5 regulatory subunit 1
chr12_-_10335499 1.44 ENSRNOT00000071567
WAS protein family, member 3
chr9_-_5329305 1.42 ENSRNOT00000078055
solute carrier family 5 member 7
chr20_+_27592379 1.41 ENSRNOT00000047000
trafficking protein particle complex 3-like
chr1_-_261090437 1.39 ENSRNOT00000072055
FRAT2, WNT signaling pathway regulator
chr20_+_38935820 1.38 ENSRNOT00000001059
heat shock transcription factor 2
chr4_+_8166082 1.38 ENSRNOT00000076429
SRSF protein kinase 2
chr10_-_87261717 1.38 ENSRNOT00000015740
keratin 27
chr17_+_18151982 1.38 ENSRNOT00000066447
kinesin family member 13A
chr3_+_159569363 1.37 ENSRNOT00000064159
TOX high mobility group box family member 2
chr8_+_119030875 1.36 ENSRNOT00000028458
myosin light chain 3
chr7_+_140315368 1.29 ENSRNOT00000081206
calcium voltage-gated channel auxiliary subunit beta 3
chr10_+_66732390 1.28 ENSRNOT00000089538
neurofibromin 1
chr16_+_20740826 1.25 ENSRNOT00000038057
CREB regulated transcription coactivator 1
chr7_+_59349745 1.25 ENSRNOT00000085334
protein tyrosine phosphatase, receptor type, B
chr3_+_148510779 1.22 ENSRNOT00000012156
XK related 7
chr3_-_91370167 1.21 ENSRNOT00000006291
proline rich 5 like
chr9_+_62291809 1.21 ENSRNOT00000090621
phospholipase C-like 1
chr5_+_90338795 1.20 ENSRNOT00000077864
ENSRNOT00000058882
similar to RIKEN cDNA 2310003M01
chr8_+_104040934 1.17 ENSRNOT00000081204
transcription factor Dp-2
chr2_+_102685513 1.13 ENSRNOT00000033940
basic helix-loop-helix family, member e22
chr4_+_157524423 1.12 ENSRNOT00000036654
zinc finger protein 384
chr13_+_95589668 1.11 ENSRNOT00000005849
zinc finger protein 238
chr8_+_128824508 1.11 ENSRNOT00000025343
myelin-associated oligodendrocyte basic protein
chr4_-_82194927 1.10 ENSRNOT00000072302
homeobox protein Hox-A9
chr4_-_87111025 1.07 ENSRNOT00000018442
kelch repeat and BTB domain containing 2
chr1_+_142679345 1.07 ENSRNOT00000034267
zinc finger and SCAN domain containing 2
chr6_-_27024129 1.06 ENSRNOT00000012273
dihydropyrimidinase-like 5
chr7_+_72772440 0.98 ENSRNOT00000009989
metadherin
chr1_+_12823363 0.95 ENSRNOT00000086790
Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
chr9_-_43139870 0.94 ENSRNOT00000021956
semaphorin 4C
chr18_+_27558089 0.93 ENSRNOT00000027499
family with sequence similarity 53, member C
chr13_-_76049363 0.93 ENSRNOT00000075865
ENSRNOT00000007455
BMP/retinoic acid inducible neural specific 2
chr2_+_69415057 0.92 ENSRNOT00000013152
cadherin 10
chr6_+_29061618 0.91 ENSRNOT00000092223
ATPase family, AAA domain containing 2B
chr18_+_47740328 0.89 ENSRNOT00000025119
synuclein, alpha interacting protein
chr6_+_83421882 0.88 ENSRNOT00000084258
leucine rich repeat and fibronectin type III domain containing 5
chr8_-_46757781 0.88 ENSRNOT00000085294

chr9_+_40817654 0.88 ENSRNOT00000037392

chr10_+_35872619 0.84 ENSRNOT00000059190
heterogeneous nuclear ribonucleoprotein H1
chr10_+_72909550 0.83 ENSRNOT00000004540
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr15_-_25505691 0.78 ENSRNOT00000074488
homeobox protein OTX2-like
chr14_+_23166633 0.73 ENSRNOT00000060109
transmembrane protease, serine 11G
chr7_-_104541392 0.71 ENSRNOT00000078116
family with sequence similarity 49, member B
chr20_-_43932361 0.71 ENSRNOT00000091030
ret finger protein-like 4B
chr2_+_189865915 0.69 ENSRNOT00000077362
interleukin enhancer binding factor 2
chr8_-_110813000 0.63 ENSRNOT00000010634
Eph receptor B1
chr13_-_50761306 0.63 ENSRNOT00000076610
ENSRNOT00000004241
proline and arginine rich end leucine rich repeat protein
chr13_+_90533365 0.56 ENSRNOT00000082469
DDB1 and CUL4 associated factor 8
chr9_-_23493081 0.54 ENSRNOT00000072144
Rh-associated glycoprotein
chr3_+_14990652 0.52 ENSRNOT00000090735
DAB2 interacting protein
chr14_+_8080275 0.51 ENSRNOT00000065965
ENSRNOT00000092542
mitogen activated protein kinase 10
chr14_-_41786084 0.50 ENSRNOT00000059439
glutaredoxin and cysteine rich domain containing 1
chr4_+_7122890 0.50 ENSRNOT00000076339
ENSRNOT00000076418
ENSRNOT00000014718
ATP binding cassette subfamily F member 2
chr6_-_105518725 0.50 ENSRNOT00000009693
ENSRNOT00000083488
mitogen-activated protein kinase kinase kinase 9
chr1_+_29191192 0.48 ENSRNOT00000018718
hes-related family bHLH transcription factor with YRPW motif 2
chr10_-_87578854 0.48 ENSRNOT00000065619
similar to keratin associated protein 4-7
chrX_-_16929907 0.47 ENSRNOT00000003971
shroom family member 4
chr2_-_95106157 0.44 ENSRNOT00000041334
LRRGT00056
chr6_-_99214251 0.41 ENSRNOT00000042682
estrogen receptor 2
chr20_-_5140304 0.37 ENSRNOT00000092646
proline-rich coiled-coil 2A
chr11_-_84633504 0.37 ENSRNOT00000052120
kelch-like family member 24
chr4_+_118207862 0.36 ENSRNOT00000085787
ENSRNOT00000023103
TIA1 cytotoxic granule-associated RNA binding protein
chr1_-_156327352 0.36 ENSRNOT00000074282
coiled-coil domain-containing protein 89-like
chr14_+_8080565 0.36 ENSRNOT00000092395
mitogen activated protein kinase 10
chr1_+_274030978 0.35 ENSRNOT00000076387
MAX interactor 1, dimerization protein
chr14_-_45376127 0.34 ENSRNOT00000059247

chr5_-_93244202 0.33 ENSRNOT00000075474
protein tyrosine phosphatase, receptor type, D
chr8_+_79489790 0.30 ENSRNOT00000091722
protogenin
chr19_-_25345790 0.29 ENSRNOT00000010050
zinc finger, SWIM-type containing 4
chr3_+_57286892 0.29 ENSRNOT00000039065
Golgi reassembly-stacking protein 2-like
chrX_-_70460536 0.29 ENSRNOT00000076824
PDZ domain containing 11
chr2_-_96509424 0.28 ENSRNOT00000090866
zinc finger, C2HC-type containing 1A
chrX_-_81866370 0.27 ENSRNOT00000042570

chr3_-_94418711 0.26 ENSRNOT00000089554
homeodomain interacting protein kinase 3
chr9_+_121456623 0.26 ENSRNOT00000056255
peptidylprolyl isomerase D-like 1
chrX_+_63343546 0.25 ENSRNOT00000076315
kelch-like family member 15
chr13_+_76942928 0.25 ENSRNOT00000040505
ring finger and WD repeat domain 2
chr1_+_259926537 0.22 ENSRNOT00000073537
cyclin J
chr2_-_197935567 0.21 ENSRNOT00000085404
regulation of nuclear pre-mRNA domain containing 2
chr1_+_240908483 0.20 ENSRNOT00000019367
Kruppel-like factor 9
chrX_-_73778595 0.19 ENSRNOT00000076081
ENSRNOT00000075926
ENSRNOT00000003782
ring finger protein, LIM domain interacting
chr13_+_76943633 0.18 ENSRNOT00000076908
ring finger and WD repeat domain 2
chr1_+_260798239 0.12 ENSRNOT00000036791
ligand dependent nuclear receptor corepressor
chr3_+_80614937 0.09 ENSRNOT00000065462
harbinger transposase derived 1
chr14_-_51462721 0.09 ENSRNOT00000015044
high mobility group box 3
chr7_-_129724303 0.04 ENSRNOT00000006034
bromodomain containing 1
chr16_-_71203609 0.04 ENSRNOT00000088458
nuclear receptor binding SET domain protein 3
chr13_+_47380406 0.04 ENSRNOT00000050289
LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
chr3_-_94833406 0.03 ENSRNOT00000049695
similar to Ac2-210
chr1_+_154606490 0.02 ENSRNOT00000024095
coiled-coil domain containing 89

Network of associatons between targets according to the STRING database.

First level regulatory network of Sox5_Sry

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological process category:

Log-likelihood per target  Total log-likelihood Term Description
3.6 14.4 GO:0003350 pulmonary myocardium development(GO:0003350)
3.5 10.5 GO:1904207 regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904207) positive regulation of chemokine (C-C motif) ligand 2 secretion(GO:1904209) positive regulation of metalloendopeptidase activity(GO:1904685)
3.3 13.3 GO:0070495 regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
3.0 26.8 GO:0061303 cornea development in camera-type eye(GO:0061303)
1.9 19.2 GO:0090500 endocardial cushion to mesenchymal transition(GO:0090500)
1.8 12.9 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell differentiation(GO:2001015)
1.6 8.1 GO:0021827 cerebral cortex tangential migration using cell-cell interactions(GO:0021823) postnatal olfactory bulb interneuron migration(GO:0021827)
1.2 10.4 GO:0016198 axon choice point recognition(GO:0016198)
1.1 4.4 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
1.1 9.9 GO:1904116 response to vasopressin(GO:1904116)
1.0 10.4 GO:0048251 elastic fiber assembly(GO:0048251)
1.0 9.2 GO:0086046 membrane depolarization during SA node cell action potential(GO:0086046)
1.0 6.1 GO:1905050 positive regulation of metallopeptidase activity(GO:1905050)
1.0 2.9 GO:0010986 positive regulation of lipoprotein particle clearance(GO:0010986)
0.9 3.6 GO:1901491 negative regulation of lymphangiogenesis(GO:1901491)
0.9 6.2 GO:0071787 endoplasmic reticulum tubular network assembly(GO:0071787)
0.8 7.5 GO:0048387 negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.8 6.1 GO:0071000 response to magnetism(GO:0071000)
0.5 29.7 GO:0045907 positive regulation of vasoconstriction(GO:0045907)
0.5 2.1 GO:0098963 dendritic transport of ribonucleoprotein complex(GO:0098961) dendritic transport of messenger ribonucleoprotein complex(GO:0098963) anterograde dendritic transport of messenger ribonucleoprotein complex(GO:0098964)
0.5 4.0 GO:0097264 self proteolysis(GO:0097264)
0.5 5.0 GO:0046684 response to pyrethroid(GO:0046684)
0.4 2.2 GO:0030070 insulin processing(GO:0030070)
0.4 2.2 GO:0002741 positive regulation of cytokine secretion involved in immune response(GO:0002741)
0.4 3.8 GO:0021942 radial glia guided migration of Purkinje cell(GO:0021942)
0.4 1.3 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.4 8.8 GO:0008210 estrogen metabolic process(GO:0008210)
0.4 9.7 GO:0045663 positive regulation of myoblast differentiation(GO:0045663)
0.4 4.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.4 1.5 GO:0021586 pons maturation(GO:0021586)
0.4 2.5 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.3 3.4 GO:1904706 negative regulation of vascular smooth muscle cell proliferation(GO:1904706)
0.3 3.3 GO:0008215 spermine metabolic process(GO:0008215)
0.3 3.9 GO:0046549 retinal rod cell development(GO:0046548) retinal cone cell development(GO:0046549)
0.3 1.9 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.3 1.3 GO:0061534 forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) gamma-aminobutyric acid secretion, neurotransmission(GO:0061534)
0.3 2.9 GO:0032808 lacrimal gland development(GO:0032808)
0.3 1.4 GO:0008292 acetylcholine biosynthetic process(GO:0008292) acetate ester biosynthetic process(GO:1900620)
0.3 2.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.3 1.6 GO:0016191 synaptic vesicle uncoating(GO:0016191)
0.3 2.9 GO:0007196 adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway(GO:0007196)
0.3 3.8 GO:0010839 negative regulation of keratinocyte proliferation(GO:0010839)
0.2 17.9 GO:0031103 axon regeneration(GO:0031103)
0.2 0.7 GO:2000567 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.2 1.0 GO:0061428 embryonic heart tube left/right pattern formation(GO:0060971) negative regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061428)
0.2 2.1 GO:0070417 cellular response to cold(GO:0070417)
0.2 1.4 GO:0072386 plus-end-directed vesicle transport along microtubule(GO:0072383) plus-end-directed organelle transport along microtubule(GO:0072386)
0.2 6.2 GO:0097435 definitive hemopoiesis(GO:0060216) fibril organization(GO:0097435)
0.2 2.9 GO:0021860 pyramidal neuron development(GO:0021860)
0.2 5.5 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.2 1.2 GO:0038203 TORC2 signaling(GO:0038203)
0.2 3.3 GO:0016339 calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339)
0.2 1.1 GO:0021960 anterior commissure morphogenesis(GO:0021960)
0.2 2.7 GO:0014051 gamma-aminobutyric acid secretion(GO:0014051)
0.2 2.4 GO:1900746 regulation of vascular endothelial growth factor signaling pathway(GO:1900746)
0.1 2.8 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 1.3 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.1 1.7 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.1 3.4 GO:0010614 negative regulation of cardiac muscle hypertrophy(GO:0010614)
0.1 0.4 GO:2000312 regulation of kainate selective glutamate receptor activity(GO:2000312)
0.1 2.1 GO:0014912 negative regulation of smooth muscle cell migration(GO:0014912)
0.1 1.4 GO:0031643 positive regulation of myelination(GO:0031643)
0.1 1.8 GO:0000712 resolution of meiotic recombination intermediates(GO:0000712)
0.1 2.0 GO:0045793 positive regulation of cell size(GO:0045793)
0.1 1.2 GO:1900122 positive regulation of receptor binding(GO:1900122)
0.1 1.7 GO:0045947 negative regulation of translational initiation(GO:0045947)
0.1 14.0 GO:0007416 synapse assembly(GO:0007416)
0.1 0.9 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.1 0.9 GO:0021535 cell migration in hindbrain(GO:0021535)
0.1 0.5 GO:0015670 carbon dioxide transport(GO:0015670)
0.1 1.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.1 1.8 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.1 4.0 GO:0072384 organelle transport along microtubule(GO:0072384)
0.1 2.7 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.1 0.8 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.1 1.4 GO:0031069 hair follicle morphogenesis(GO:0031069)
0.1 1.5 GO:0002053 positive regulation of mesenchymal cell proliferation(GO:0002053)
0.1 1.4 GO:0002026 regulation of the force of heart contraction(GO:0002026)
0.1 3.2 GO:0048663 neuron fate commitment(GO:0048663)
0.1 0.4 GO:1903608 protein localization to cytoplasmic stress granule(GO:1903608)
0.0 1.6 GO:0015991 ATP hydrolysis coupled proton transport(GO:0015991)
0.0 0.3 GO:1903361 protein localization to basolateral plasma membrane(GO:1903361)
0.0 0.2 GO:0071630 nucleus-associated proteasomal ubiquitin-dependent protein catabolic process(GO:0071630)
0.0 0.9 GO:0090083 regulation of inclusion body assembly(GO:0090083)
0.0 3.5 GO:0003333 amino acid transmembrane transport(GO:0003333)
0.0 3.9 GO:0018107 peptidyl-threonine phosphorylation(GO:0018107)
0.0 5.5 GO:0050806 positive regulation of synaptic transmission(GO:0050806)
0.0 3.8 GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator(GO:0072332)
0.0 0.5 GO:0007256 activation of JNKK activity(GO:0007256)
0.0 0.1 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.8 GO:0071542 dopaminergic neuron differentiation(GO:0071542)
0.0 3.4 GO:0050684 regulation of mRNA processing(GO:0050684)
0.0 1.0 GO:0031663 lipopolysaccharide-mediated signaling pathway(GO:0031663)
0.0 1.4 GO:0034698 response to gonadotropin(GO:0034698)
0.0 6.2 GO:0001525 angiogenesis(GO:0001525)
0.0 0.8 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.9 GO:0071300 cellular response to retinoic acid(GO:0071300)
0.0 1.1 GO:0021766 hippocampus development(GO:0021766)
0.0 0.5 GO:0060122 inner ear receptor stereocilium organization(GO:0060122)
0.0 0.9 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)

Gene overrepresentation in cellular component category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 10.4 GO:0071953 elastic fiber(GO:0071953)
1.7 10.5 GO:0033269 internode region of axon(GO:0033269)
1.3 10.4 GO:0032584 growth cone membrane(GO:0032584)
1.1 34.1 GO:0031430 M band(GO:0031430)
0.9 10.5 GO:1990454 L-type voltage-gated calcium channel complex(GO:1990454)
0.6 6.2 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.5 6.7 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 4.0 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
0.5 1.5 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.5 2.8 GO:0005608 laminin-3 complex(GO:0005608)
0.4 6.1 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 2.1 GO:0033093 Weibel-Palade body(GO:0033093)
0.3 1.6 GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221)
0.3 2.5 GO:0031209 SCAR complex(GO:0031209)
0.3 16.4 GO:0009925 basal plasma membrane(GO:0009925)
0.3 3.6 GO:0005652 nuclear lamina(GO:0005652)
0.3 5.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.2 9.7 GO:0044295 axonal growth cone(GO:0044295)
0.2 6.2 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.2 0.5 GO:1990032 parallel fiber(GO:1990032)
0.2 2.9 GO:0031362 anchored component of external side of plasma membrane(GO:0031362)
0.2 2.1 GO:0035253 ciliary rootlet(GO:0035253)
0.1 3.7 GO:0030673 axolemma(GO:0030673)
0.1 7.8 GO:0048786 presynaptic active zone(GO:0048786)
0.1 1.4 GO:0030008 TRAPP complex(GO:0030008)
0.1 34.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.1 1.3 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.1 1.2 GO:0031932 TORC2 complex(GO:0031932)
0.1 10.7 GO:0031674 I band(GO:0031674)
0.1 1.1 GO:0071565 nBAF complex(GO:0071565)
0.1 0.4 GO:0097165 nuclear stress granule(GO:0097165)
0.1 5.9 GO:0044853 plasma membrane raft(GO:0044853)
0.1 1.4 GO:0032588 trans-Golgi network membrane(GO:0032588)
0.1 2.9 GO:0042734 presynaptic membrane(GO:0042734)
0.0 3.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.5 GO:0060091 kinocilium(GO:0060091)
0.0 2.3 GO:0031901 early endosome membrane(GO:0031901)
0.0 16.4 GO:0009986 cell surface(GO:0009986)
0.0 0.5 GO:0016580 Sin3 complex(GO:0016580)
0.0 41.1 GO:0005615 extracellular space(GO:0005615)
0.0 8.2 GO:0043235 receptor complex(GO:0043235)
0.0 0.4 GO:0030057 desmosome(GO:0030057)
0.0 1.1 GO:0045171 intercellular bridge(GO:0045171)
0.0 2.7 GO:0008021 synaptic vesicle(GO:0008021)
0.0 2.7 GO:0031514 motile cilium(GO:0031514)
0.0 1.1 GO:0016605 PML body(GO:0016605)
0.0 7.6 GO:0005887 integral component of plasma membrane(GO:0005887)
0.0 1.1 GO:0005882 intermediate filament(GO:0005882)

Gene overrepresentation in molecular function category:

Log-likelihood per target  Total log-likelihood Term Description
2.6 10.4 GO:0035727 lysophosphatidic acid binding(GO:0035727)
2.3 13.5 GO:0098821 activin receptor activity, type I(GO:0016361) BMP receptor activity(GO:0098821)
2.0 9.9 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
1.6 29.7 GO:0005523 tropomyosin binding(GO:0005523)
1.5 9.2 GO:0086059 voltage-gated calcium channel activity involved SA node cell action potential(GO:0086059)
1.3 16.5 GO:0030215 semaphorin receptor binding(GO:0030215)
1.0 11.6 GO:0019911 structural constituent of myelin sheath(GO:0019911)
0.9 7.5 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.8 3.9 GO:0008502 melatonin receptor activity(GO:0008502)
0.7 2.9 GO:0001642 group III metabotropic glutamate receptor activity(GO:0001642)
0.7 5.7 GO:0071253 connexin binding(GO:0071253)
0.6 1.9 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.6 1.7 GO:0001605 adrenomedullin receptor activity(GO:0001605)
0.6 4.4 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
0.5 12.6 GO:0043274 phospholipase binding(GO:0043274)
0.5 2.9 GO:0035473 lipase binding(GO:0035473)
0.4 4.4 GO:0008046 axon guidance receptor activity(GO:0008046)
0.3 1.4 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.3 3.6 GO:0042043 neurexin family protein binding(GO:0042043)
0.2 2.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 0.7 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.2 9.0 GO:0051393 alpha-actinin binding(GO:0051393)
0.2 12.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.2 1.3 GO:0045545 syndecan binding(GO:0045545)
0.2 2.1 GO:0034190 apolipoprotein receptor binding(GO:0034190)
0.2 5.0 GO:1905030 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.2 1.6 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.2 0.5 GO:0035939 microsatellite binding(GO:0035939)
0.2 1.0 GO:0050693 LBD domain binding(GO:0050693)
0.2 4.7 GO:0004683 calmodulin-dependent protein kinase activity(GO:0004683)
0.1 2.7 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.1 0.5 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.1 0.5 GO:0035662 Toll-like receptor 4 binding(GO:0035662)
0.1 0.4 GO:1903924 estradiol binding(GO:1903924)
0.1 6.5 GO:0005080 protein kinase C binding(GO:0005080)
0.1 1.3 GO:0008331 high voltage-gated calcium channel activity(GO:0008331)
0.1 8.1 GO:0005518 collagen binding(GO:0005518)
0.1 0.5 GO:0022840 leak channel activity(GO:0022840) narrow pore channel activity(GO:0022842)
0.1 2.2 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.2 GO:0070679 inositol 1,4,5 trisphosphate binding(GO:0070679)
0.1 8.6 GO:0005178 integrin binding(GO:0005178)
0.1 2.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.1 4.4 GO:0015459 potassium channel regulator activity(GO:0015459)
0.1 1.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.1 4.0 GO:0019894 kinesin binding(GO:0019894)
0.1 2.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.1 0.4 GO:0001162 RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding(GO:0001162)
0.1 1.5 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.9 GO:0005109 frizzled binding(GO:0005109)
0.1 1.4 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.5 GO:0042169 SH2 domain binding(GO:0042169)
0.0 3.3 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 2.1 GO:0005044 scavenger receptor activity(GO:0005044)
0.0 2.7 GO:0030276 clathrin binding(GO:0030276)
0.0 4.6 GO:0017124 SH3 domain binding(GO:0017124)
0.0 7.5 GO:0008017 microtubule binding(GO:0008017)
0.0 3.2 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 0.8 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 8.1 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.5 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 2.7 GO:0051015 actin filament binding(GO:0051015)
0.0 12.8 GO:0005509 calcium ion binding(GO:0005509)
0.0 5.2 GO:0030246 carbohydrate binding(GO:0030246)
0.0 1.7 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.9 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 0.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.0 0.4 GO:0017091 AU-rich element binding(GO:0017091)
0.0 1.4 GO:0001085 RNA polymerase II transcription factor binding(GO:0001085)

Gene overrepresentation in curated gene sets: canonical pathways category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 29.7 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.4 13.5 PID ALK1 PATHWAY ALK1 signaling events
0.4 9.7 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.4 6.1 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 16.9 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.3 14.8 PID NCADHERIN PATHWAY N-cadherin signaling events
0.3 10.4 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 6.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.2 5.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 22.7 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.1 4.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.1 22.2 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.1 1.7 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.1 3.7 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.1 3.0 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 1.3 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.0 2.9 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.6 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 10.7 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 0.9 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.0 5.6 NABA MATRISOME ASSOCIATED Ensemble of genes encoding ECM-associated proteins including ECM-affilaited proteins, ECM regulators and secreted factors
0.0 1.0 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.0 1.3 PID AP1 PATHWAY AP-1 transcription factor network
0.0 0.5 PID RAS PATHWAY Regulation of Ras family activation
0.0 0.5 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.0 0.4 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in curated gene sets: REACTOME pathways category:

Log-likelihood per target  Total log-likelihood Term Description
2.0 27.5 REACTOME KERATAN SULFATE DEGRADATION Genes involved in Keratan sulfate degradation
0.4 5.7 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.4 9.9 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.4 11.6 REACTOME MYOGENESIS Genes involved in Myogenesis
0.3 4.4 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.3 13.7 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.3 2.0 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.2 3.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.2 4.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.2 3.3 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.2 2.1 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.1 2.1 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.1 2.5 REACTOME CRMPS IN SEMA3A SIGNALING Genes involved in CRMPs in Sema3A signaling
0.1 2.9 REACTOME CLASS C 3 METABOTROPIC GLUTAMATE PHEROMONE RECEPTORS Genes involved in Class C/3 (Metabotropic glutamate/pheromone receptors)
0.1 1.7 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 1.4 REACTOME ACETYLCHOLINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Acetylcholine Neurotransmitter Release Cycle
0.1 2.2 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.1 1.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.1 3.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 0.4 REACTOME P53 DEPENDENT G1 DNA DAMAGE RESPONSE Genes involved in p53-Dependent G1 DNA Damage Response
0.1 7.1 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.1 4.8 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 1.6 REACTOME INSULIN RECEPTOR RECYCLING Genes involved in Insulin receptor recycling
0.0 1.3 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 1.4 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.0 1.4 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 2.8 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.0 2.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.5 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.0 1.7 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 1.7 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases